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Vol. 33. Issue 12.
Pages 807-809 (December 2014)
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Vol. 33. Issue 12.
Pages 807-809 (December 2014)
Image in Cardiology
Open Access
Leiomyosarcoma of the inferior vena cava in a patient with Budd-Chiari syndrome
Leiomiosarcoma da veia cava inferior num doente com síndrome de Budd-Chiari
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Andrea Barisona,b,
Corresponding author
barison@sssup.it

Corresponding author.
, Luigi Emilio Pastormerloa, Gianluca Mirizzia, Elisa Castelluccioc, Pier Giorgio Mascia, Claudio Passinoa,b
a Fondazione Toscana Gabriele Monasterio, Pisa, Italy
b Scuola Superiore Sant’Anna, Pisa, Italy
c University of Pisa, Pisa, Italy
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A 65-year-old man with no history of cardiovascular disease was admitted because of abdominal pain, nausea and lower limb edema. At clinical examination he presented hepatomegaly, ascites and laboratory evidence of liver failure. The echocardiogram (Figure 1A) showed preserved biventricular function, but a large irregular mass was visible in the right atrium (arrow; Supplementary data, Movie 1 and 2). Computed tomography (Figure 1B) showed patchy contrast uptake and positron emission tomography (Figure 1C) showed pathological uptake of 18-fluoro-deoxy-glucose in the mass (arrow), extending along the inferior vena cava (arrowheads), suggesting a neoplastic nature. At cardiovascular magnetic resonance (Figure 1D and E; Supplementary data, Movie 3 and 4) the mass involved the right atrium (arrow) and extended into the inferior vena cava (arrowheads); moreover, it presented irregular contours and signal characteristics typical of a neoplastic mass, being irregularly hyperintense in T1-weighted fast-spin-echo imaging (Figure 2A), T2-weighted short-tau inversion recovery fast-spin-echo imaging (Figure 2B) and post-contrast T1-weighted gradient-echo imaging (Figure 2C). Because of his advanced disease and poor clinical condition, the patient did not undergo surgical intervention and died a few days after diagnosis. Autopsy confirmed the mass to be a leiomyosarcoma arising from the inferior vena cava with thrombotic apposition (Figure 3), composed of spindle cells with positive immunohistochemistry staining for smooth muscle actin, desmin and vimentin.

Figure 1.

(A) Apical 4-chamber echocardiographic view, showing preserved biventricular function, but a large irregular mass inside the right atrium (arrow); (B) computed tomography, 4-chamber view, showing patchy contrast uptake inside the right atrial mass (arrow); (C) positron emission tomography, coronal view, showing pathological uptake of 18-fluoro-deoxy-glucose in the mass (arrow), extending along the inferior vena cava (arrowheads), suggesting a neoplastic nature with variable retrograde thrombotic apposition; (D and E) cardiovascular magnetic resonance image of the neoplastic mass occupying most of the right atrium (D, 4-chamber cine view) and extending along the inferior vena cava (E, parasagittal cine view).

(0.14MB).
Figure 2.

Magnetic resonance long-axis image of the heart, showing a large mass inside the right atrium (arrow) appearing irregularly hyperintense in a T1-weighted fast-spin-echo sequence (A), a T2-weighted short-tau inversion recovery fast-spin-echo sequence (B) and a post-contrast T1-weighted gradient-echo sequence (C). These signal characteristics, together with the local invasiveness of the mass, indicated a neoplastic nature.

(0.06MB).
Figure 3.

Macroscopic autopsy specimen of the inferior vena cava (after removal of the large intravascular thrombus), showing an irregular tissue mass growing from the vessel wall; immunohistochemistry study identified the growth as a leiomyosarcoma (positive for smooth muscle actin, desmin and vimentin).

(0.1MB).

Leiomyosarcoma of the inferior vena cava is a rare tumor that presents in an insidious manner with non-specific symptoms. Diagnosis often comes too late and, even in patients who undergo radical surgical resection, prognosis remains extremely poor. Multimodality imaging is crucial for early diagnosis and therapy.

Ethical disclosuresProtection of human and animal subjects

The authors declare that no experiments were performed on humans or animals for this study.

Confidentiality of data

The authors declare that no patient data appear in this article.

Right to privacy and informed consent

The authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document.

Conflicts of interest

The authors have no conflicts of interest to declare.

Appendix A
Supplementary data

(0.68MB)

Echocardiographic 4-chamber view showing a large irregular mass inside the right atrium. Left and right ventricular systolic function appear otherwise preserved.

(0.76MB)

Echocardiographic subxiphoid view showing a large irregular mass inside the right atrium, extending along the inferior vena cava.

(0.19MB)

Magnetic resonance steady-state free precession 4-chamber cine imaging showing a large irregular mass inside the right atrium. Left and right ventricular systolic function appear otherwise preserved.

(0.25MB)

Magnetic resonance steady-state free precession parasagittal long-axis cine imaging showing a large irregular mass inside the right atrium, extending along the inferior vena cava.

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