array:26 [
  "pii" => "S0870255116300117"
  "issn" => "08702551"
  "doi" => "10.1016/j.repc.2016.03.002"
  "estado" => "S300"
  "fechaPublicacion" => "2016-05-01"
  "aid" => "813"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "dis"
  "cita" => "Rev Port Cardiol. 2016;35:275-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2465
    "formatos" => array:3 [
      "EPUB" => 185
      "HTML" => 1600
      "PDF" => 680
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:20 [
      "pii" => "S2174204916300435"
      "issn" => "21742049"
      "doi" => "10.1016/j.repce.2016.05.003"
      "estado" => "S300"
      "fechaPublicacion" => "2016-05-01"
      "aid" => "813"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "dis"
      "cita" => "Rev Port Cardiol. 2016;35:275-6"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 1881
        "formatos" => array:3 [
          "EPUB" => 125
          "HTML" => 1291
          "PDF" => 465
        ]
      ]
      "en" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
        "titulo" => "One small step for exosomes&#44; one giant leap for Kawasaki disease"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "275"
            "paginaFinal" => "276"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "Um pequeno passo para os exossomas&#44; um salto gigante para a doen&#231;a de Kawasaki"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Henrique Gir&#227;o"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "Henrique"
                "apellidos" => "Gir&#227;o"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0870255116300117"
          "doi" => "10.1016/j.repc.2016.03.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116300117?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204916300435?idApp=UINPBA00004E"
      "url" => "/21742049/0000003500000005/v3_201704120129/S2174204916300435/v3_201704120129/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S087025511630004X"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2015.11.017"
    "estado" => "S300"
    "fechaPublicacion" => "2016-05-01"
    "aid" => "806"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Cardiol. 2016;35:277-83"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2802
      "formatos" => array:3 [
        "EPUB" => 220
        "HTML" => 2002
        "PDF" => 580
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Characterization of left atrial dysfunction in hypereosinophilic syndrome &#8211; Insights from the Motion analysis of the heart and great vessels by three-dimensional speckle tracking echocardiography in pathological cases &#40;MAGYAR-Path&#41; Study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "277"
          "paginaFinal" => "283"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Caracteriza&#231;&#227;o da disfun&#231;&#227;o auricular esquerda na s&#237;ndrome hipereosinof&#237;lica &#8211; vis&#227;o da an&#225;lise de movimentos do cora&#231;&#227;o e dos grandes vasos por ecocardiografia tridimensional <span class="elsevierStyleItalic">speckle tracking</span> em casos patol&#243;gicos &#8211; estudo MAGYAR-Path"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2179
              "Ancho" => 2496
              "Tamanyo" => 356613
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Images from three-dimensional full-volume dataset showing left atrium&#58; apical 4-chamber &#40;A&#41; and 2-chamber views &#40;B&#41; and short-axis views at basal &#40;C3&#41;&#44; mid- &#40;C5&#41; and superior &#40;C7&#41; left atrial level are demonstrated together with left atrial volumetric data and a three-dimensional cast of the left atrium&#46; Time-segmental strain curves of all 16 left atrial segments and global left atrial volume changes throughout the cardiac cycle are also presented&#46; White arrow&#58; peak strain&#46; LA&#58; left atrium&#59; LV&#58; left ventricle&#59; RA&#58; right atrium&#59; RV&#58; right ventricle&#59; V<span class="elsevierStyleInf">max</span>&#44; V<span class="elsevierStyleInf">min</span> and V<span class="elsevierStyleInf">preA</span>&#58; maximum and minimum left atrial volumes and left atrial volume before atrial contraction&#44; respectively&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Attila Nemes, Imelda Marton, P&#233;ter Domsik, Anita Kalapos, &#201;va P&#243;sfai, Szabolcs Modok, Zita Borb&#233;nyi, Tam&#225;s Forster"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Attila"
              "apellidos" => "Nemes"
            ]
            1 => array:2 [
              "nombre" => "Imelda"
              "apellidos" => "Marton"
            ]
            2 => array:2 [
              "nombre" => "P&#233;ter"
              "apellidos" => "Domsik"
            ]
            3 => array:2 [
              "nombre" => "Anita"
              "apellidos" => "Kalapos"
            ]
            4 => array:2 [
              "nombre" => "&#201;va"
              "apellidos" => "P&#243;sfai"
            ]
            5 => array:2 [
              "nombre" => "Szabolcs"
              "apellidos" => "Modok"
            ]
            6 => array:2 [
              "nombre" => "Zita"
              "apellidos" => "Borb&#233;nyi"
            ]
            7 => array:2 [
              "nombre" => "Tam&#225;s"
              "apellidos" => "Forster"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S217420491630037X"
        "doi" => "10.1016/j.repce.2015.11.025"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217420491630037X?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087025511630004X?idApp=UINPBA00004E"
    "url" => "/08702551/0000003500000005/v3_201702080059/S087025511630004X/v3_201702080059/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S0870255116300038"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2015.11.016"
    "estado" => "S300"
    "fechaPublicacion" => "2016-05-01"
    "aid" => "805"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Cardiol. 2016;35:265-73"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3058
      "formatos" => array:3 [
        "EPUB" => 209
        "HTML" => 2233
        "PDF" => 616
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Proteomic analysis associated with coronary artery dilatation caused by Kawasaki disease using serum exosomes"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "265"
          "paginaFinal" => "273"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "An&#225;lise prote&#243;mica associada a dilata&#231;&#227;o da art&#233;ria coron&#225;ria causada pela doen&#231;a de Kawasaki com utiliza&#231;&#227;o de exossoma s&#233;rico"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 1483
              "Ancho" => 2360
              "Tamanyo" => 169689
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Western blot analysis for expression of SHBG&#44; LRG1 and TF in six Kawasaki disease patients with coronary artery dilatation &#40;CAD&#41; and six healthy controls&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Li Zhang, Wei Wang, Jun Bai, Yu-Fen Xu, Lai-Qing Li, Liang Hua, Li Deng, Hong-Ling Jia"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Li"
              "apellidos" => "Zhang"
            ]
            1 => array:2 [
              "nombre" => "Wei"
              "apellidos" => "Wang"
            ]
            2 => array:2 [
              "nombre" => "Jun"
              "apellidos" => "Bai"
            ]
            3 => array:2 [
              "nombre" => "Yu-Fen"
              "apellidos" => "Xu"
            ]
            4 => array:2 [
              "nombre" => "Lai-Qing"
              "apellidos" => "Li"
            ]
            5 => array:2 [
              "nombre" => "Liang"
              "apellidos" => "Hua"
            ]
            6 => array:2 [
              "nombre" => "Li"
              "apellidos" => "Deng"
            ]
            7 => array:2 [
              "nombre" => "Hong-Ling"
              "apellidos" => "Jia"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2174204916300770"
        "doi" => "10.1016/j.repce.2016.06.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204916300770?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116300038?idApp=UINPBA00004E"
    "url" => "/08702551/0000003500000005/v3_201702080059/S0870255116300038/v3_201702080059/en/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:20 [
      "pii" => "S0870255116300038"
      "issn" => "08702551"
      "doi" => "10.1016/j.repc.2015.11.016"
      "estado" => "S300"
      "fechaPublicacion" => "2016-05-01"
      "aid" => "805"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Rev Port Cardiol. 2016;35:265-73"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 3058
        "formatos" => array:3 [
          "EPUB" => 209
          "HTML" => 2233
          "PDF" => 616
        ]
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
        "titulo" => "Proteomic analysis associated with coronary artery dilatation caused by Kawasaki disease using serum exosomes"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "pt"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "265"
            "paginaFinal" => "273"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "An&#225;lise prote&#243;mica associada a dilata&#231;&#227;o da art&#233;ria coron&#225;ria causada pela doen&#231;a de Kawasaki com utiliza&#231;&#227;o de exossoma s&#233;rico"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "pt" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figure 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 1483
                "Ancho" => 2360
                "Tamanyo" => 169689
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Western blot analysis for expression of SHBG&#44; LRG1 and TF in six Kawasaki disease patients with coronary artery dilatation &#40;CAD&#41; and six healthy controls&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Li Zhang, Wei Wang, Jun Bai, Yu-Fen Xu, Lai-Qing Li, Liang Hua, Li Deng, Hong-Ling Jia"
            "autores" => array:8 [
              0 => array:2 [
                "nombre" => "Li"
                "apellidos" => "Zhang"
              ]
              1 => array:2 [
                "nombre" => "Wei"
                "apellidos" => "Wang"
              ]
              2 => array:2 [
                "nombre" => "Jun"
                "apellidos" => "Bai"
              ]
              3 => array:2 [
                "nombre" => "Yu-Fen"
                "apellidos" => "Xu"
              ]
              4 => array:2 [
                "nombre" => "Lai-Qing"
                "apellidos" => "Li"
              ]
              5 => array:2 [
                "nombre" => "Liang"
                "apellidos" => "Hua"
              ]
              6 => array:2 [
                "nombre" => "Li"
                "apellidos" => "Deng"
              ]
              7 => array:2 [
                "nombre" => "Hong-Ling"
                "apellidos" => "Jia"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2174204916300770"
          "doi" => "10.1016/j.repce.2016.06.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204916300770?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116300038?idApp=UINPBA00004E"
      "url" => "/08702551/0000003500000005/v3_201702080059/S0870255116300038/v3_201702080059/en/main.assets"
    ]
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
    "titulo" => "One small step for exosomes&#44; one giant leap for Kawasaki disease"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "275"
        "paginaFinal" => "276"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Henrique Gir&#227;o"
        "autores" => array:1 [
          0 => array:3 [
            "nombre" => "Henrique"
            "apellidos" => "Gir&#227;o"
            "email" => array:1 [
              0 => "hmgirao&#64;fmed&#46;uc&#46;pt"
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "CNC&#46;IBILI&#44; Institute of Biomedical Imaging and Life Sciences &#40;IBILI&#41;&#44; Faculty of Medicine&#44; University of Coimbra&#44; Coimbra&#44; Portugal"
            "identificador" => "aff0005"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Um pequeno passo para os exossomas&#44; um salto gigante para a doen&#231;a de Kawasaki"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Communication between cardiac cells is essential to ensure heart homeostasis and function&#46; This intercellular communication can occur directly between adjacent cells&#44; through connexin-containing channels called gap junctions&#44; or indirectly at long distances&#44; via extracellular vesicles that mediate the transport of biomolecules between cells&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> According to their origin and size&#44; extracellular vesicles can be divided into apoptotic bodies&#44; microvesicles and exosomes&#46; Exosomes are formed when organelles of the endocytic pathway named multivesicular bodies fuse with the plasma membrane and release the intraluminal vesicles into the extracellular space&#46; The secreted exosomes contain proteins&#44; lipids and nucleic acids characteristic of the cells from which they originate&#44; thus mirroring the biological status of the producing cells&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> Since they can be easily detected in various biological fluids such as blood&#44; urine&#44; amniotic fluid and saliva&#44; exosomes have emerged as potent diagnostic and prognostic tools&#46; After their release&#44; exosomes can be taken up by recipient cells&#44; where they can elicit a cell response that may involve changes in cell function and behavior&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> Considerable enthusiasm has been aroused concerning exosomes due to the fact that these vesicles may constitute promising targets in terms of identification of new human disease biomarkers&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> For this&#44; precise characterization of exosome content is of utmost importance&#44; in order to establish reliable biological markers&#46; Furthermore&#44; exosomes can be considered as carriers of biological information&#44; facilitating the transfer of molecules and signals between distant cells located in different organs and tissues&#46; Therefore fine-tuned regulation of exosome-mediated communication is vital to ensure the organism&#39;s homeostasis&#46; Disturbance of these mechanisms can contribute to the dissemination and propagation of harmful signals throughout the body&#44; leading to morbidities and pathologies associated with syndromes&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The study by Jia et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> in this issue of the <span class="elsevierStyleItalic">Journal</span> identified the protein profile of exosomes isolated from the blood of patients with coronary artery dilatation due to Kawasaki disease&#44; the commonest childhood cause of acquired heart disease in developed countries&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> The authors found that the content of exosomes isolated from patients with Kawasaki disease differs from those from healthy controls in 38 proteins&#46; Most of these proteins are involved in the inflammation and coagulation cascades&#44; in agreement with the pathophysiology of the disease&#44; which causes general inflammation of the blood vessels&#44; particularly the coronary arteries&#46; Since early and accurate diagnosis of the disease is vital for successful therapeutic intervention&#44; the present study makes an important contribution to the fight against Kawasaki disease&#46; Although the results need to be confirmed in a larger cohort of patients&#44; they are very promising&#44; as they may pave the way for the development of more effective strategies to detect Kawasaki disease in its initial stages&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0015" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:7 [
            0 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46; Martins-Marques"
                            1 => "S&#46; Catarino"
                            2 => "M&#46; Zuzarte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1042/BJ20141370"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochem J"
                        "fecha" => "2015"
                        "volumen" => "467"
                        "paginaInicial" => "231"
                        "paginaFinal" => "245"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25605500"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microvesicles and exosomes for intracardiac communication"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;P&#46; Sluijter"
                            1 => "V&#46; Verhage"
                            2 => "J&#46;C&#46; Deddens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/cvr/cvu022"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Res"
                        "fecha" => "2014"
                        "volumen" => "102"
                        "paginaInicial" => "302"
                        "paginaFinal" => "311"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24488559"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;R&#46; Soares"
                            1 => "T&#46; Martins-Marques"
                            2 => "T&#46; Ribeiro-Rodrigues"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/srep13243"
                      "Revista" => array:5 [
                        "tituloSerie" => "Sci Rep"
                        "fecha" => "2015"
                        "volumen" => "5"
                        "paginaInicial" => "13243"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26285688"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microvesicles and exosomes&#58; new players in metabolic and cardiovascular disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46; Lawson"
                            1 => "J&#46;M&#46; Vicencio"
                            2 => "D&#46;M&#46; Yellon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1530/JOE-15-0201"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Endocrinol"
                        "fecha" => "2016"
                        "volumen" => "228"
                        "paginaInicial" => "R57"
                        "paginaFinal" => "R71"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26743452"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac extracellular vesicles in normal and infarcted heart"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;A&#46; Chistiakov"
                            1 => "A&#46;N&#46; Orekhov"
                            2 => "Y&#46;V&#46; Bobryshev"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3390/ijms17111904"
                      "Revista" => array:4 [
                        "tituloSerie" => "Int J Mol Sci"
                        "fecha" => "2016"
                        "volumen" => "17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27854308"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proteomic analysis associated with coronary artery dilatation caused by Kawasaki disease using serum exosomes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46;-L&#46; Jia"
                            1 => "W&#46; Wang"
                            2 => "J&#46; Bai"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.repc.2015.11.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Port Cardiol"
                        "fecha" => "2016"
                        "volumen" => "35"
                        "paginaInicial" => "265"
                        "paginaFinal" => "273"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27118092"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adjunctive testing in the evaluation of adults after Kawasaki disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;B&#46; Daniels"
                            1 => "J&#46;C&#46; Burns"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1253/circj.CJ-15-0996"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circ J"
                        "fecha" => "2015"
                        "volumen" => "79"
                        "paginaInicial" => "2299"
                        "paginaFinal" => "2305"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26467080"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/08702551/0000003500000005/v3_201702080059/S0870255116300117/v3_201702080059/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "29261"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Artigos Originais"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08702551/0000003500000005/v3_201702080059/S0870255116300117/v3_201702080059/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116300117?idApp=UINPBA00004E"
]
Partilhar
Informação da revista
Vol. 35. Núm. 5.
Páginas 275-276 (maio 2016)
Partilhar
Partilhar
Baixar PDF
Mais opções do artigo
Vol. 35. Núm. 5.
Páginas 275-276 (maio 2016)
Editorial comment
Open Access
One small step for exosomes, one giant leap for Kawasaki disease
Um pequeno passo para os exossomas, um salto gigante para a doença de Kawasaki
Visitas
5575
Henrique Girão
CNC.IBILI, Institute of Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Conteúdo relacionado
Li Zhang, Wei Wang, Jun Bai, Yu-Fen Xu, Lai-Qing Li, Liang Hua, Li Deng, Hong-Ling Jia
Este item recebeu

Under a Creative Commons license
Informação do artigo
Texto Completo
Bibliografia
Baixar PDF
Estatísticas
Texto Completo

Communication between cardiac cells is essential to ensure heart homeostasis and function. This intercellular communication can occur directly between adjacent cells, through connexin-containing channels called gap junctions, or indirectly at long distances, via extracellular vesicles that mediate the transport of biomolecules between cells.1 According to their origin and size, extracellular vesicles can be divided into apoptotic bodies, microvesicles and exosomes. Exosomes are formed when organelles of the endocytic pathway named multivesicular bodies fuse with the plasma membrane and release the intraluminal vesicles into the extracellular space. The secreted exosomes contain proteins, lipids and nucleic acids characteristic of the cells from which they originate, thus mirroring the biological status of the producing cells.2 Since they can be easily detected in various biological fluids such as blood, urine, amniotic fluid and saliva, exosomes have emerged as potent diagnostic and prognostic tools. After their release, exosomes can be taken up by recipient cells, where they can elicit a cell response that may involve changes in cell function and behavior.3 Considerable enthusiasm has been aroused concerning exosomes due to the fact that these vesicles may constitute promising targets in terms of identification of new human disease biomarkers.4 For this, precise characterization of exosome content is of utmost importance, in order to establish reliable biological markers. Furthermore, exosomes can be considered as carriers of biological information, facilitating the transfer of molecules and signals between distant cells located in different organs and tissues. Therefore fine-tuned regulation of exosome-mediated communication is vital to ensure the organism's homeostasis. Disturbance of these mechanisms can contribute to the dissemination and propagation of harmful signals throughout the body, leading to morbidities and pathologies associated with syndromes.5

The study by Jia et al.6 in this issue of the Journal identified the protein profile of exosomes isolated from the blood of patients with coronary artery dilatation due to Kawasaki disease, the commonest childhood cause of acquired heart disease in developed countries.7 The authors found that the content of exosomes isolated from patients with Kawasaki disease differs from those from healthy controls in 38 proteins. Most of these proteins are involved in the inflammation and coagulation cascades, in agreement with the pathophysiology of the disease, which causes general inflammation of the blood vessels, particularly the coronary arteries. Since early and accurate diagnosis of the disease is vital for successful therapeutic intervention, the present study makes an important contribution to the fight against Kawasaki disease. Although the results need to be confirmed in a larger cohort of patients, they are very promising, as they may pave the way for the development of more effective strategies to detect Kawasaki disease in its initial stages.

Conflicts of interest

The author has no conflicts of interest to declare.

References
[1]
T. Martins-Marques, S. Catarino, M. Zuzarte, et al.
Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes.
Biochem J, 467 (2015), pp. 231-245
[2]
J.P. Sluijter, V. Verhage, J.C. Deddens, et al.
Microvesicles and exosomes for intracardiac communication.
Cardiovasc Res, 102 (2014), pp. 302-311
[3]
A.R. Soares, T. Martins-Marques, T. Ribeiro-Rodrigues, et al.
Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells.
Sci Rep, 5 (2015), pp. 13243
[4]
C. Lawson, J.M. Vicencio, D.M. Yellon, et al.
Microvesicles and exosomes: new players in metabolic and cardiovascular disease.
J Endocrinol, 228 (2016), pp. R57-R71
[5]
D.A. Chistiakov, A.N. Orekhov, Y.V. Bobryshev.
Cardiac extracellular vesicles in normal and infarcted heart.
[6]
H.-L. Jia, W. Wang, J. Bai.
Proteomic analysis associated with coronary artery dilatation caused by Kawasaki disease using serum exosomes.
Rev Port Cardiol, 35 (2016), pp. 265-273
[7]
L.B. Daniels, J.C. Burns.
Adjunctive testing in the evaluation of adults after Kawasaki disease.
Circ J, 79 (2015), pp. 2299-2305
Copyright © 2016. Sociedade Portuguesa de Cardiologia
Baixar PDF
Idiomas
Revista Portuguesa de Cardiologia
Opções de artigo
Ferramentas
en pt

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

Ao assinalar que é «Profissional de Saúde», declara conhecer e aceitar que a responsável pelo tratamento dos dados pessoais dos utilizadores da página de internet da Revista Portuguesa de Cardiologia (RPC), é esta entidade, com sede no Campo Grande, n.º 28, 13.º, 1700-093 Lisboa, com os telefones 217 970 685 e 217 817 630, fax 217 931 095 e com o endereço de correio eletrónico revista@spc.pt. Declaro para todos os fins, que assumo inteira responsabilidade pela veracidade e exatidão da afirmação aqui fornecida.