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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Contrast-induced nephropathy &#40;CIN&#41; is a major concern in daily practice for everyone working in interventional cardiology&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The use of contrast agents has been growing due to the increasing number of procedures that use them&#44; such as&#58; structural heart therapies and primary angioplasty for ST-segment elevation myocardial infarction &#40;STEMI&#41;&#46; Contrast-induced nephropathy has a major impact on prognosis after primary percutaneous coronary intervention &#40;PCI&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1&#44;2</span></a> In this particular setting&#44; it is problematic due to the clinical instability of the patient and the impossibility of prevention in an emerging situation&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Contrast-induced nephropathy is a well-known cause of acute renal failure but the underlying mechanisms are yet to be fully understood&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The evidence is in favor of a combination of direct toxic effects on tubular epithelial cells and renal ischemia as the pathogenetic role&#46; The generation of reactive oxygen species&#44; which in turn scavenge nitric oxide&#44; further increases hypoxia&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Identified risk factors for CIN are the baseline renal function itself&#44; diabetes&#44; acute myocardial infarction&#44; shock and the volume of contrast medium administered during the procedure&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Among patients with STEMI&#44; the role of contrast agents has been questioned in acute kidney injury &#40;AKI&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> In this study&#44; Caspi et al&#46; concluded that the risk for AKI was similar among STEMI patients regardless of exposure to contrast material&#46; Independent predictors of AKI in patients who underwent primary PCI included age &#8805;70 years&#44; insulin-treated diabetes&#44; diuretic therapy&#44; previous infarction&#44; baseline estimated glomerular filtration rate&#44; and variables related to the presence of pump failure &#40;higher Killip class&#44; intra-aortic balloon pump use&#41; and reduced left ventricular ejection fraction but not contrast agent dose&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In this issue Fatih Aksoy et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> assessed the association between total oxidant status &#40;TOS&#41;&#44; total antioxidant capacity &#40;TAC&#41; and CIN in patients with STEMI&#46; They assessed a cohort of 341 patients&#46; In a multivariate regression analysis&#44; they concluded that high-sensitivity C-reactive protein&#44; uric acid and oxidative status index predicted the development of CIN&#46; They also suggest that incorporating these variables into existing risk scores like the Mehran risk score<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> could improve its accuracy&#46; Nevertheless&#44; only 16&#46;7&#37; of these patients developed CIN&#44; which the authors acknowledged could have influenced their results&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The results suggest&#44; nonetheless&#44; that TOC&#44; TAC and oxidative stress index are associated with the development of CIN&#44; reinforcing the possibility that oxidative stress may be partially responsible for the development of CIN&#44; as already suggested by others&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Preventive measures for CIN&#44; such as fluid administration&#44; pharmacological strategies&#44; use of different contrast agents and renal replacement therapies&#44; have been extensively assessed in many trials&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">There seems to be some consensus on fluid administration as a means of protecting from CIN&#44; but the results from trials are conflicting&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">11&#44;12</span></a> The addition of sodium bicarbonate may provide additional kidney protection by alkalinizing renal tubular fluid and thereby minimizing tubular damage&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Fluid administration possibly associated with furosemide forced diuresis seems to be a good strategy&#44; although there is the risk of hypovolemia&#46; The fear of giving too much volume&#44; mainly in patients with low ejection fraction can&#44; on the other hand&#44; lead to suboptimal protection&#46; Renal Guard&#44; a device enabling volume administration to be balanced with urine output&#44; showed that a high urine output was achievable&#44; while avoiding hypovolemia&#44; thus protecting from CIN&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Randomized trials with N-acetylcysteine had conflicting results but this drug can have a protective effect&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The authors tried to identify further markers of increased risk of AKI&#46; 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Vol. 40. Núm. 7.
Páginas 499-500 (julho 2021)
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Vol. 40. Núm. 7.
Páginas 499-500 (julho 2021)
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Contrast-induced nephropathy: Can we better predict and prevent it?
Nefropatia induzida por contraste: poderemos prever e preveni-la melhor?
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2911
Pedro Pinto Cardosoa,b
a Structural and Coronary Heart Disease Unit, Centro Cardiovascular da Universidade de Lisboa, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
b Serviço de Cardiologia, Departamento de Coração e Vasos, CHULN Hospital de Santa Maria, Lisboa, Portugal
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Fatih Aksoy, Hasan Aydın Baş, Ali Bağcı, Hasan Basri Savaş
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Contrast-induced nephropathy (CIN) is a major concern in daily practice for everyone working in interventional cardiology.

The use of contrast agents has been growing due to the increasing number of procedures that use them, such as: structural heart therapies and primary angioplasty for ST-segment elevation myocardial infarction (STEMI). Contrast-induced nephropathy has a major impact on prognosis after primary percutaneous coronary intervention (PCI).1,2 In this particular setting, it is problematic due to the clinical instability of the patient and the impossibility of prevention in an emerging situation.3

Contrast-induced nephropathy is a well-known cause of acute renal failure but the underlying mechanisms are yet to be fully understood.

The evidence is in favor of a combination of direct toxic effects on tubular epithelial cells and renal ischemia as the pathogenetic role. The generation of reactive oxygen species, which in turn scavenge nitric oxide, further increases hypoxia.4,5

Identified risk factors for CIN are the baseline renal function itself, diabetes, acute myocardial infarction, shock and the volume of contrast medium administered during the procedure.4

Among patients with STEMI, the role of contrast agents has been questioned in acute kidney injury (AKI).6 In this study, Caspi et al. concluded that the risk for AKI was similar among STEMI patients regardless of exposure to contrast material. Independent predictors of AKI in patients who underwent primary PCI included age ≥70 years, insulin-treated diabetes, diuretic therapy, previous infarction, baseline estimated glomerular filtration rate, and variables related to the presence of pump failure (higher Killip class, intra-aortic balloon pump use) and reduced left ventricular ejection fraction but not contrast agent dose.

In this issue Fatih Aksoy et al.7 assessed the association between total oxidant status (TOS), total antioxidant capacity (TAC) and CIN in patients with STEMI. They assessed a cohort of 341 patients. In a multivariate regression analysis, they concluded that high-sensitivity C-reactive protein, uric acid and oxidative status index predicted the development of CIN. They also suggest that incorporating these variables into existing risk scores like the Mehran risk score8 could improve its accuracy. Nevertheless, only 16.7% of these patients developed CIN, which the authors acknowledged could have influenced their results.

The results suggest, nonetheless, that TOC, TAC and oxidative stress index are associated with the development of CIN, reinforcing the possibility that oxidative stress may be partially responsible for the development of CIN, as already suggested by others.9,10

Preventive measures for CIN, such as fluid administration, pharmacological strategies, use of different contrast agents and renal replacement therapies, have been extensively assessed in many trials.

There seems to be some consensus on fluid administration as a means of protecting from CIN, but the results from trials are conflicting.11,12 The addition of sodium bicarbonate may provide additional kidney protection by alkalinizing renal tubular fluid and thereby minimizing tubular damage.13

Fluid administration possibly associated with furosemide forced diuresis seems to be a good strategy, although there is the risk of hypovolemia. The fear of giving too much volume, mainly in patients with low ejection fraction can, on the other hand, lead to suboptimal protection. Renal Guard, a device enabling volume administration to be balanced with urine output, showed that a high urine output was achievable, while avoiding hypovolemia, thus protecting from CIN.14

Randomized trials with N-acetylcysteine had conflicting results but this drug can have a protective effect.15

The authors tried to identify further markers of increased risk of AKI. Still, measuring TOC and TAC in daily practice does not seem feasible. The result of this study may however contribute to further investigation on the mechanisms of CIN and possibly lead to novel therapeutic options to prevent CIN.

Currently, hydration and possibly sodium bicarbonate/N-acetylcysteine seem to be the best and only way to prevent CIN.

Conflicts of interest

The author has no conflicts of interest to declare.

References
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H.M. Sadeghi, G.W. Stone, C.L. Grines, et al.
Impact of renal insufficiency in patients undergoing primary angioplasty for acute myocardial infarction.
[2]
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Contrast-induced nephropathy in patients undergoing primary angioplasty for acute myocardial infarction.
[3]
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Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention.
[4]
P.C.Y. Wong, Z. Li, J. Guo, et al.
Pathophysiology of contrast-induced nephropathy.
[5]
E. Seeliger, M. Sendeski, C.S. Rihal, et al.
Contrast-induced kidney injury: mechanisms, risk factors, and prevention.
[6]
O. Caspi, M. Habib, Y. Cohen, et al.
Acute kidney injury after primary angioplasty: is contrast-induced nephropathy the culprit?.
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F. Aksoy, H. Aydın Baş, A. Bağcı, et al.
Predictive value of oxidant and antioxidant status for contrast-induced nephropathy after percutaneous coronary intervention for ST-segment elevation myocardial infarction.
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Oxygen free radicals and contrast nephropathy.
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[11]
E.C. Nijssen, P.J. Nelemans, R.J. Rennenberg, et al.
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C. Mueller, G. Buerkle, H.J. Buettner, et al.
Prevention of contrast media-associated nephropathy: randomized comparison of 2 hydration regimens in 1620 patients undergoing coronary angioplasty.
[13]
S.S. Brar, A.Y.J. Shen, M.B. Jorgensen, et al.
Sodium bicarbonate vs sodium chloride for the prevention of contrast medium-induced nephropathy in patients undergoing coronary angiography: a randomized trial.
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C. Briguori, G. Visconti, M. Donahue, et al.
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[15]
M. Tepel, M. van der Giet, C. Schwarzfeld, et al.
Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine.
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Revista Portuguesa de Cardiologia
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Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

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