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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Mitral annulus calcification is a common echocardiographic finding&#44; particularly in the elderly and in end-stage renal disease patients under chronic dialysis&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Caseous calcification of the mitral annulus &#40;CCMA&#41; or liquefaction necrosis of mitral annulus calcification is a rare evolution of mitral annular calcification&#44; with a prevalence of 0&#46;6&#37; in this population and of 0&#46;06&#8211;0&#46;07&#37; in large series of patients of all ages&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Early recognition of this entity avoids an invasive diagnostic approach&#44; since it is benign and&#44; unlike intracardiac tumors and abscesses&#44; has a favorable prognosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4&#44;8&#8211;10</span></a> Echocardiography typically identifies this entity as a round&#44; calcified mass with an echolucent&#44; liquid-like inner part&#46; The authors present the case of an 84-year-old woman with caseous calcification of the posterior mitral annulus&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case report</span><p id="par0010" class="elsevierStylePara elsevierViewall">An 84-year-old woman&#44; with a history of hypertension and dyslipidemia&#44; was admitted to our institution because of an intracardiac mass&#46; She described a five-month history of shortness of breath on exertion &#40;NYHA functional class III&#41; and peripheral edema&#46; Physical examination revealed a grade III&#47;VI mitral systolic murmur&#46; The electrocardiogram was unremarkable&#46; Laboratory tests results showed no significant alterations&#46; The transthoracic echocardiogram demonstrated a large&#44; round&#44; heterogeneous&#44; echodense mass at the base of the posterior leaflet &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Doppler examination documented severe mitral regurgitation&#46; The three-dimensional transthoracic echocardiogram revealed the mass involving the posterior mitral annulus&#44; distorting it into a more triangular shape &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Three-dimensional transthoracic color flow imaging showed an eccentric mitral regurgitation jet originating from the posteromedial commissure &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The transesophageal echocardiogram confirmed the location of the mass and severe mitral regurgitation &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#44; with two jets identified&#44; one central and the other eccentric&#44; apparently originating from the posteromedial commissure&#46; Cardiac magnetic resonance &#40;CMR&#41; imaging was performed to better evaluate the mass&#46; This showed a hypointense mass in the posterior region of the mitral annulus&#47;basal segment of the inferior wall &#40;<a class="elsevierStyleCrossRefs" href="#fig0025">Figs&#46; 5 and 6</a>&#41;&#46; Rest perfusion CMR demonstrated hypoperfusion of the mass compared to normal myocardium &#40;<a class="elsevierStyleCrossRef" href="#fig0035">Fig&#46; 7</a>&#41;&#46; Phase-sensitive inversion-recovery CMR showed late gadolinium enhancement in the peripheral margin of the mass &#40;<a class="elsevierStyleCrossRef" href="#fig0040">Fig&#46; 8</a>&#41;&#46; On the basis of the above findings&#44; a presumptive diagnosis of a centrally liquefied mass containing a high-protein or hemorrhagic content with an inflammatory and&#47;or fibrotic wall was made&#46; A multislice computed tomography &#40;CT&#41; scan of the heart was also performed&#44; demonstrating a relatively homogeneous&#44; high-density mass with foci of calcification &#40;<a class="elsevierStyleCrossRefs" href="#fig0045">Figs&#46; 9 and 10</a>&#41;&#46; A multi-modality imaging approach confirmed the diagnosis of caseous calcification of the posterior mitral annulus&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><elsevierMultimedia ident="fig0030"></elsevierMultimedia><elsevierMultimedia ident="fig0035"></elsevierMultimedia><elsevierMultimedia ident="fig0040"></elsevierMultimedia><elsevierMultimedia ident="fig0045"></elsevierMultimedia><elsevierMultimedia ident="fig0050"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The patient refused surgery&#46; Medical treatment was optimized&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">CCMA is a rare evolution of mitral annular calcification&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Echocardiography typically identifies this entity as a round&#44; calcified&#44; echogenic mass&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> CMR reveals a mass between the posterior mitral annulus and adjacent myocardium&#44; with no enhancement after contrast administration and with strong peripheral enhancement 10 minutes after gadolinium administration with the use of the contrast-enhanced inversion-recovery technique&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> CT confirms the calcified aspect of the mass&#46; Histological examination of the inner fluid usually reveals an amorphous&#44; basophilic content&#44; composed of a putty-like admixture of fatty acids&#44; cholesterol&#44; calcium and inflammatory cells&#44; mainly macrophages&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6</span></a> Early recognition of this entity avoids an invasive diagnostic approach&#44; since it is benign and&#44; unlike intracardiac tumors and abscesses&#44; has a favorable prognosis&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Surgery should be reserved for cases with severe co-existent mitral valve dysfunction&#44; originating from compromised mitral leaflet coaptation secondary to mitral annulus distortion due to CCMA&#46; There are brief references in the literature to possible spontaneous resolution of this entity&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> CCMA may rarely be associated with heart rhythm disturbances and systemic embolism&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusions</span><p id="par0025" class="elsevierStylePara elsevierViewall">Caseous calcification of the mitral annulus &#40;CCMA&#41; or liquefaction necrosis of mitral annulus calcification is a rare evolution of mitral annular calcification&#46; Although transthoracic echocardiography can be sensitive in diagnosing this entity&#44; the diagnosis can sometimes still be inconclusive&#46; Multi-modality imaging with CMR or CT can lead to a definitive diagnosis&#44; avoiding a surgical approach&#46; Once the diagnosis is made&#44; the patient should be treated medically and be monitored clinically and echocardiographically unless there is associated severe mitral valve dysfunction&#44; in which case cardiac surgery is the best therapeutic option&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mitral annulus calcification is a common echocardiographic finding&#44; particularly in the elderly and in end-stage renal disease patients under chronic dialysis&#46; Caseous calcification or liquefaction necrosis of mitral annulus calcification is a rare evolution of mitral annular calcification&#46; Early recognition of this entity avoids an invasive diagnostic approach&#44; since it is benign and&#44; unlike intracardiac tumors and abscesses&#44; has a favorable prognosis&#46; The authors present the case of an 84-year-old woman with a suspicious large&#44; echodense mass at the level of the posterior mitral leaflet with associated severe mitral regurgitation&#46; Cardiac magnetic resonance imaging demonstrated a hypoperfused mass with strong peripheral enhancement 10 minutes after gadolinium administration&#46; Multislice computed tomography showed the calcified nature of the mass&#46; A multi-modality imaging approach confirmed the diagnosis of caseous calcification of the posterior mitral annulus&#46; The patient refused surgical treatment&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A calcifica&#231;&#227;o do anel mitral &#233; um achado ecocardiogr&#225;fico comum&#44; particularmente em idosos e doentes com insufici&#234;ncia renal terminal em di&#225;lise&#46; A degeneresc&#234;ncica caseosa&#44; ou necrose liquefeita&#44; da calcifica&#231;&#227;o do anel mitral &#233; uma forma rara de calcifica&#231;&#227;o do anel mitral&#46; O reconhecimento precoce desta entidade evita procedimentos diagn&#243;sticos invasivos na medida em que &#233; uma patologia benigna e&#44; ao contr&#225;rio de tumores e abcesso card&#237;acos&#44; tem um bom progn&#243;stico&#46; Os autores apresentam o caso cl&#237;nico de uma doente de 84 anos de idade com uma massa hiperecog&#233;nica ao n&#237;vel do folheto posterior da v&#225;lvula mitral&#44; associada a insufici&#234;ncia mitral severa&#46; A resson&#226;ncia magn&#233;tica card&#237;aca demonstrou uma massa hipoperfundida&#44; com realce tardio&#44; ap&#243;s administra&#231;&#227;o de gadol&#237;neo&#46; A tomografia computadorizada card&#237;aca evidenciou a natureza calcificada da les&#227;o&#46; Uma abordagem multi-imagem permitiu o diagn&#243;stico de calcifica&#231;&#227;o caseosa do anel mitral posterior&#46; A doente recusou cirurgia card&#237;aca&#46;</p>"
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Journal Information
Vol. 31. Issue 4.
Pages 313-316 (April 2012)
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Vol. 31. Issue 4.
Pages 313-316 (April 2012)
Case report
Open Access
Caseous calcification of the mitral annulus: A multi-modality imaging perspective
Degenerescência caseosa da calcificação do anel mitral: uma perspectiva multi-imagem
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Sílvia Ribeiroa,
Corresponding author
silviamartinsribeiro@gmail.com

Corresponding author.
, Alberto Salgadoa, Nuno Saloméa, Nuno Bettencourtb, Pedro Azevedoa, António Costeiraa, Adelino Correiaa
a Cardiology Department – Braga Hospital, Braga, Portugal
b Vila Nova de Gaia/Espinho Hospital Centre, Vila Nova de Gaia, Portugal
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Abstract

Mitral annulus calcification is a common echocardiographic finding, particularly in the elderly and in end-stage renal disease patients under chronic dialysis. Caseous calcification or liquefaction necrosis of mitral annulus calcification is a rare evolution of mitral annular calcification. Early recognition of this entity avoids an invasive diagnostic approach, since it is benign and, unlike intracardiac tumors and abscesses, has a favorable prognosis. The authors present the case of an 84-year-old woman with a suspicious large, echodense mass at the level of the posterior mitral leaflet with associated severe mitral regurgitation. Cardiac magnetic resonance imaging demonstrated a hypoperfused mass with strong peripheral enhancement 10 minutes after gadolinium administration. Multislice computed tomography showed the calcified nature of the mass. A multi-modality imaging approach confirmed the diagnosis of caseous calcification of the posterior mitral annulus. The patient refused surgical treatment.

Keywords:
Intracardiac mass
Caseous calcification of mitral annulus
Mitral regurgitation
Transthoracic echocardiography
Cardiac computed tomography
Cardiac magnetic resonance
Resumo

A calcificação do anel mitral é um achado ecocardiográfico comum, particularmente em idosos e doentes com insuficiência renal terminal em diálise. A degenerescêncica caseosa, ou necrose liquefeita, da calcificação do anel mitral é uma forma rara de calcificação do anel mitral. O reconhecimento precoce desta entidade evita procedimentos diagnósticos invasivos na medida em que é uma patologia benigna e, ao contrário de tumores e abcesso cardíacos, tem um bom prognóstico. Os autores apresentam o caso clínico de uma doente de 84 anos de idade com uma massa hiperecogénica ao nível do folheto posterior da válvula mitral, associada a insuficiência mitral severa. A ressonância magnética cardíaca demonstrou uma massa hipoperfundida, com realce tardio, após administração de gadolíneo. A tomografia computadorizada cardíaca evidenciou a natureza calcificada da lesão. Uma abordagem multi-imagem permitiu o diagnóstico de calcificação caseosa do anel mitral posterior. A doente recusou cirurgia cardíaca.

Palavras-chave:
Massa intracardíaca
Calcificação caseosa do anel mitral
Insuficiência mitral
Ecocardiograma transtorácico
Angio-TC cardíaca
Ressonância magnética cardíaca
Full Text
Introduction

Mitral annulus calcification is a common echocardiographic finding, particularly in the elderly and in end-stage renal disease patients under chronic dialysis.1 Caseous calcification of the mitral annulus (CCMA) or liquefaction necrosis of mitral annulus calcification is a rare evolution of mitral annular calcification, with a prevalence of 0.6% in this population and of 0.06–0.07% in large series of patients of all ages.2,3 Early recognition of this entity avoids an invasive diagnostic approach, since it is benign and, unlike intracardiac tumors and abscesses, has a favorable prognosis.2–4,8–10 Echocardiography typically identifies this entity as a round, calcified mass with an echolucent, liquid-like inner part. The authors present the case of an 84-year-old woman with caseous calcification of the posterior mitral annulus.

Case report

An 84-year-old woman, with a history of hypertension and dyslipidemia, was admitted to our institution because of an intracardiac mass. She described a five-month history of shortness of breath on exertion (NYHA functional class III) and peripheral edema. Physical examination revealed a grade III/VI mitral systolic murmur. The electrocardiogram was unremarkable. Laboratory tests results showed no significant alterations. The transthoracic echocardiogram demonstrated a large, round, heterogeneous, echodense mass at the base of the posterior leaflet (Fig. 1). Doppler examination documented severe mitral regurgitation. The three-dimensional transthoracic echocardiogram revealed the mass involving the posterior mitral annulus, distorting it into a more triangular shape (Fig. 2). Three-dimensional transthoracic color flow imaging showed an eccentric mitral regurgitation jet originating from the posteromedial commissure (Fig. 3). The transesophageal echocardiogram confirmed the location of the mass and severe mitral regurgitation (Fig. 4), with two jets identified, one central and the other eccentric, apparently originating from the posteromedial commissure. Cardiac magnetic resonance (CMR) imaging was performed to better evaluate the mass. This showed a hypointense mass in the posterior region of the mitral annulus/basal segment of the inferior wall (Figs. 5 and 6). Rest perfusion CMR demonstrated hypoperfusion of the mass compared to normal myocardium (Fig. 7). Phase-sensitive inversion-recovery CMR showed late gadolinium enhancement in the peripheral margin of the mass (Fig. 8). On the basis of the above findings, a presumptive diagnosis of a centrally liquefied mass containing a high-protein or hemorrhagic content with an inflammatory and/or fibrotic wall was made. A multislice computed tomography (CT) scan of the heart was also performed, demonstrating a relatively homogeneous, high-density mass with foci of calcification (Figs. 9 and 10). A multi-modality imaging approach confirmed the diagnosis of caseous calcification of the posterior mitral annulus.

Figure 1.

Two-dimensional echocardiogram, parasternal long-axis view (A) and apical two-chamber view (B), revealing an echodense mass at the base of the posterior leaflet.

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Figure 2.

Three-dimensional transthoracic echocardiogram with a visualization perspective from within the left ventricle. Note the mass involving the posterior mitral leaflet, distorting its shape.

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Figure 3.

Three-dimensional transthoracic color flow imaging of mitral regurgitation, showing an eccentric jet originating from the posteromedial commissure.

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Figure 4.

Transesophageal two-chamber view demonstrating severe mitral regurgitation.

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Figure 5.

Steady-state free precession cine CMR image in modified two-chamber view, showing a hypointense mass (arrow) in the posterior region of the mitral annulus/basal segment of the inferior wall.

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Figure 6.

Steady-state free precession cine CMR image in basal short-axis view, demonstrating the mass (arrow).

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Figure 7.

Rest perfusion CMR imaging in short-axis view. Note the hypoperfusion of the mass compared to normal myocardium.

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Figure 8.

Phase-sensitive inversion-recovery CMR sequence showing late gadolinium enhancement in the peripheral margin of the mass.

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Figure 9.

Maximum intensity multislice CT projection showing a partially calcified hyperintense mass (arrow) in non-contrast acquisition (four-chamber and short-axis view).

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Figure 10.

Multislice CT volume-rendering technique revealing the extent of the mass (arrow) and its relation to the posterior mitral annulus.

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The patient refused surgery. Medical treatment was optimized.

Discussion

CCMA is a rare evolution of mitral annular calcification.2,3 Echocardiography typically identifies this entity as a round, calcified, echogenic mass.4 CMR reveals a mass between the posterior mitral annulus and adjacent myocardium, with no enhancement after contrast administration and with strong peripheral enhancement 10 minutes after gadolinium administration with the use of the contrast-enhanced inversion-recovery technique.5 CT confirms the calcified aspect of the mass. Histological examination of the inner fluid usually reveals an amorphous, basophilic content, composed of a putty-like admixture of fatty acids, cholesterol, calcium and inflammatory cells, mainly macrophages.4,6 Early recognition of this entity avoids an invasive diagnostic approach, since it is benign and, unlike intracardiac tumors and abscesses, has a favorable prognosis.7 Surgery should be reserved for cases with severe co-existent mitral valve dysfunction, originating from compromised mitral leaflet coaptation secondary to mitral annulus distortion due to CCMA. There are brief references in the literature to possible spontaneous resolution of this entity.8,9 CCMA may rarely be associated with heart rhythm disturbances and systemic embolism.10

Conclusions

Caseous calcification of the mitral annulus (CCMA) or liquefaction necrosis of mitral annulus calcification is a rare evolution of mitral annular calcification. Although transthoracic echocardiography can be sensitive in diagnosing this entity, the diagnosis can sometimes still be inconclusive. Multi-modality imaging with CMR or CT can lead to a definitive diagnosis, avoiding a surgical approach. Once the diagnosis is made, the patient should be treated medically and be monitored clinically and echocardiographically unless there is associated severe mitral valve dysfunction, in which case cardiac surgery is the best therapeutic option.

Conflicts of interest

The authors have no conflicts of interest to declare.

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