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abril 2023 Genetic polymorphisms in apolipoprotein E and atrial fibrillation
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Vol. 42. Núm. 4.
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Vol. 42. Núm. 4.
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Letter to the Editor
DOI: 10.1016/j.repc.2022.09.003
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Genetic polymorphisms in apolipoprotein E and atrial fibrillation
Polimorfismos genéticos na apolipoproteína E e fibrilhação auricular
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Rujittika Mungmunpuntipantipa,
Autor para correspondência
rujittika@gmail.com

Corresponding author.
, Viroj Wiwanitkitb
a Private Academic Consultant, Bangkok, Thailand
b Honorary Professor, Dr DY Patil Vidhyapeeth, Pune, India
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Dear Editor,

We would like to share ideas on the publication “Correlation between genetic polymorphisms in apolipoprotein E and atrial fibrillation.”1

Atrial fibrillation (AF) and genetic variations in apolipoprotein E (ApoE) were investigated by Wang et al.1 ApoE4 is an AF-sensitive phenotype, according to Wang et al., who also reported that ApoE polymorphisms had an impact on the occurrence of AF.1 The inherited component may or may not affect AF. In this study, the impact of a polymorphism is examined. We agree that the underlying genetic factor under study might be related to AF, however numerous genetic variants have been linked to AF. Gene polymorphisms in the GJA1, ATFB5, and ADAMTS-13 families are some examples.2–4 Future research should take into account the effects of new, possibly puzzling genetic variations.

Conflict of interest

None declared.
References
[1]
Y. Wang, H. Lou, M. Wang, et al.
Correlation between genetic polymorphisms in apolipoprotein E and atrial fibrillation.
Rev Port Cardiol, 41 (2022), pp. 417-423
http://dx.doi.org/10.1016/j.repc.2021.03.013 | Medline
[2]
S. Okamura, H. Ochi, Y. Onohara, et al.
GJA1 gene polymorphism is a genetic predictor of recurrence following pulmonary vein isolation in patients with paroxysmal atrial fibrillation.
Heart Rhythm, 19 (2022), pp. 2044-2050
http://dx.doi.org/10.1016/j.hrthm.2022.08.024 | Medline
[3]
G. Abdullaeva, A. Abdullaev, A. Kevorkov, et al.
Interrelation between the rs2200733 polymorphism of the ATFB5 gene and atrial fibrillation in Uzbek patients.
Turk Kardiyol Dern Ars, 49 (2021), pp. 404-409
http://dx.doi.org/10.5543/tkda.2021.08434 | Medline
[4]
H.J. Wang, M. Xiao, Z. Zeng, et al.
Correlation analysis between ADAMTS-13 gene polymorphism and hypertension-induced atrial fibrillation.
Eur Rev Med Pharmacol Sci, 24 (2020), pp. 2674-2682
http://dx.doi.org/10.26355/eurrev_202003_20537 | Medline
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