We would like to share ideas on the publication “Correlation between genetic polymorphisms in apolipoprotein E and atrial fibrillation.”1
Atrial fibrillation (AF) and genetic variations in apolipoprotein E (ApoE) were investigated by Wang et al.1 ApoE4 is an AF-sensitive phenotype, according to Wang et al., who also reported that ApoE polymorphisms had an impact on the occurrence of AF.1 The inherited component may or may not affect AF. In this study, the impact of a polymorphism is examined. We agree that the underlying genetic factor under study might be related to AF, however numerous genetic variants have been linked to AF. Gene polymorphisms in the GJA1, ATFB5, and ADAMTS-13 families are some examples.2–4 Future research should take into account the effects of new, possibly puzzling genetic variations.
Conflict of interestNone declared.
