Left ventricular deformation in hemophilia (from the MAGYAR-Path Study)

array:23 ["pii" => "S0870255122000646" "issn" => "08702551" "doi" => "10.1016/j.repc.2021.07.012" "estado" => "S300" "fechaPublicacion" => "2022-05-01" "aid" => "1910" "copyright" => "Sociedade Portuguesa de Cardiologia" "copyrightAnyo" => "2022" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Rev Port Cardiol. 2022;41:441-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemAnterior" => array:19 [ "pii" => "S0870255122000634" "issn" => "08702551" "doi" => "10.1016/j.repc.2021.06.018" "estado" => "S300" "fechaPublicacion" => "2022-05-01" "aid" => "1909" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Rev Port Cardiol. 2022;41:437-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "Letter to the Editor" "titulo" => "Lipoprotein(a) apheresis restores coronary microcirculation in refractory angina" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "437" "paginaFinal" => "439" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "A aférese da lipoproteinemia (a) restaura a microcirculação coronária na angina refratária" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 751 "Ancho" => 1500 "Tamanyo" => 151124 ] ] "descripcion" => array:1 [ "en" => "Coronary angiography after multiple percutaneous coronary artery revascularizations (A, *) showing chronic occlusion of the posterior descending artery (B, arrowhead)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Francesco Sbrana, Beatrice Dal Pino, Giovanni Donato Aquaro, Federico Bigazzi, Giuseppe Vergaro, Tiziana Sampietro" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Francesco" "apellidos" => "Sbrana" ] 1 => array:2 [ "nombre" => "Beatrice" "apellidos" => "Dal Pino" ] 2 => array:2 [ "nombre" => "Giovanni Donato" "apellidos" => "Aquaro" ] 3 => array:2 [ "nombre" => "Federico" "apellidos" => "Bigazzi" ] 4 => array:2 [ "nombre" => "Giuseppe" "apellidos" => "Vergaro" ] 5 => array:2 [ "nombre" => "Tiziana" "apellidos" => "Sampietro" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122000634?idApp=UINPBA00004E" "url" => "/08702551/0000004100000005/v1_202205200629/S0870255122000634/v1_202205200629/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "Letter to the Editor" "titulo" => "Left ventricular deformation in hemophilia (from the MAGYAR-Path Study)" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "441" "paginaFinal" => "443" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Attila Nemes, Árpád Kormányos, Klára Vezendi, Imelda Marton, Zita Borbényi" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Attila" "apellidos" => "Nemes" "email" => array:1 [ 0 => "nemes.attila@med.u-szeged.hu" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Árpád" "apellidos" => "Kormányos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Klára" "apellidos" => "Vezendi" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Imelda" "apellidos" => "Marton" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "Zita" "apellidos" => "Borbényi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Medicine, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Division of Haematology, Department of Medicine, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Transfusiology, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Deformação miocárdica ventricular esquerda na hemofilia (do estudo MAGYAR-Path)" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2213 "Ancho" => 2508 "Tamanyo" => 450804 ] ] "descripcion" => array:1 [ "en" => "Images from three-dimensional (3D) speckle-tracking echocardiographic analysis in apical 4-chamber view (A), apical 2-chamber view (B) and apical (C3), mid-ventricular (C5) and basal (C7) left ventricular (LV) short-axis views together with a 3D virtual model of the LV (red D), LV volumetric data on the cardiac cycle (red E) and time – LV segmental and global strain curves (colored lines) with a time – LV volume changes curve (dashed line) during the cardiac cycle (red F). LA: left atrium; LV: left ventricle; RA: right atrium; RV: right ventricle." ] ] ] "textoCompleto" => "Hemophilia is the most common severe coagulation disorder (deficiency of factor VIII causing type A and deficiency of factor IX causing type B).<a class="elsevierStyleCrossRef" href="#bib0040">1</a> Hemophilia-related changes in left ventricular (LV) function have been little examined. Three-dimensional (3D) speckle-tracking echocardiography (3DSTE) can provide detailed assessment of LV contractility represented by LV strains.<a class="elsevierStyleCrossRefs" href="#bib0045">2,3</a> The present study was designed to compare 3DSTE-derived LV strains between patients with hemophilia and matched controls.The study analyzed 16 male patients with hemophilia, three of whom were excluded due to insufficient image quality. Eleven patients had hemophilia A, while two had hemophilia B. Mean age was 42.1±19.5 years. Hypertension, hypercholesterolemia, diabetes mellitus, HCV positivity and hemophilic arthropathy were present in five, three, two, nine and eight patients, respectively. All patients were treated with a 1000-6000 U/week dose of factors for each patient. Their results were compared to those of 15 healthy male controls with a mean age of 46.3±6.0 years.Complete two-dimensional Doppler echocardiography (2DDE) and 3DSTE were performed in all hemophilia patients and controls. Results are from the MAGYAR-Path (Motion Analysis of the heart and Great vessels bY three-dimensionAl speckle-tRacking echocardiography in Pathological cases) Study.<a class="elsevierStyleCrossRef" href="#bib0045">2</a> The institutional ethics committee at the University of Szeged approved the study, which complied with the 1975 Declaration of Helsinki (and updated versions) and all hemophilia patients and controls gave informed consent.2DDE and 3DSTE were performed on a Toshiba Artida cardiac ultrasound system using a broadband 1-5 MHz PST-30SBP phased array transducer and a PST-25SX matrix array transducer (Toshiba Medical Systems, Tokyo, Japan), respectively. 2DDE-derived chamber quantifications and Doppler assessments were performed according to the guidelines.<a class="elsevierStyleCrossRefs" href="#bib0045">2,3</a> 3DSTE was performed according to recent practice with offline analysis by 3D Wall Motion Tracking software as detailed previously. Global, mean segmental and regional LV strains in longitudinal (LS), circumferential (CS) and radial (RS) directions were calculated. Combined strains (area strain, AS, and 3D strain, 3DS) were also measured (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>).<a class="elsevierStyleCrossRefs" href="#bib0050">3,4</a><elsevierMultimedia ident="fig0005"></elsevierMultimedia>2DDE data did not differ between hemophilia patients and controls (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Doppler echocardiography did not identify grade ≥1 valvular regurgitation or valvular stenosis in any patients or controls. 3DSTE-derived global and mean segmental LV strains did not show differences between groups, while only regional basal and midventricular LV circumferential strains (CSs) were significantly reduced in patients with hemophilia compared to healthy controls (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).<elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia>In a recent study, higher probability of cardiac disease, LV systolic dysfunction, coronary artery disease/microvascular disease, and LV electrical remodeling were detected in patients with hemophilia A compared to matched controls.<a class="elsevierStyleCrossRef" href="#bib0060">5</a> Moreover, impaired myocardial LV systolic function represented by increased myocardial performance index has also been demonstrated, related to arterial stiffness, in these patients.<a class="elsevierStyleCrossRef" href="#bib0065">6</a> Although the number of hemophilia patients examined in the present study was small, significant reductions in 3DSTE-derived regional LV CSs were observed. No global, mean segmental or other regional LV strains differed between the groups examined. This finding appears to be important in the context of previous results including reduced apical LV rotation and twist in hemophilia.<a class="elsevierStyleCrossRef" href="#bib0070">7</a> Regional LV deformation abnormalities in hemophilia could be explained by various factors including hemophilia-related increased aortic stiffness, altered blood quality, accompanying risk factors, and others.<a class="elsevierStyleCrossRef" href="#bib0065">6</a> However, further studies are warranted to confirm these findings.Conflicts of interestThe authors have no conflicts of interest to declare." "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2213 "Ancho" => 2508 "Tamanyo" => 450804 ] ] "descripcion" => array:1 [ "en" => "Images from three-dimensional (3D) speckle-tracking echocardiographic analysis in apical 4-chamber view (A), apical 2-chamber view (B) and apical (C3), mid-ventricular (C5) and basal (C7) left ventricular (LV) short-axis views together with a 3D virtual model of the LV (red D), LV volumetric data on the cardiac cycle (red E) and time – LV segmental and global strain curves (colored lines) with a time – LV volume changes curve (dashed line) during the cardiac cycle (red F). LA: left atrium; LV: left ventricle; RA: right atrium; RV: right ventricle." ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "A: transmitral late diastolic inflow velocity; E: transmitral early diastolic inflow velocity; LA: left atrial, LV: left ventricular." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Controls (n=15) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Hemophilia patients (n=13) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LA diameter, mm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40.0±4.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38.6±3.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LV end-diastolic diameter, mm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47.9±3.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50.4±3.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.04 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LV end-diastolic volume, ml \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">108.0±20.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">122.3±18.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.06 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LV end-systolic diameter, mm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32.2±2.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">31.8±3.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LV end-systolic volume, ml \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38.4±7.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40.8±9.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Interventricular septum, mm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.6±1.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.9±1.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LV posterior wall, mm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.4±1.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.8±1.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E, cm/s \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">71.8±19.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">74.1±13.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">A, cm/s \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">62.1±15.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">65.6±13.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E/A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.20±0.35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.08±0.28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LV ejection fraction, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">64.5±3.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">66.9±4.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.08 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2909146.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Two-dimensional echocardiographic data of hemophilia patients and controls." ] ] 2 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Controls (n=15) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Hemophilia patients (n=13) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Global strains</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">RS, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.5±10.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21.2±9.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CS, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-25.8±3.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-23.8±4.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LS, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-15.6±2.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-15.8±3.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3DS, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28.1±10.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.6±9.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AS, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-38.3±3.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-36.9±4.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mean segmental strains</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">RS, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28.0±10.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.9±10.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CS, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-27.0±3.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-25.6±3.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LS, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-16.5±2.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-14.6±4.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3DS, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30.3±9.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.5±10.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AS, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-39.4±3.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-38.2±5.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Regional strains</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">RS basal, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">33.8±14.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30.5±13.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">RS mid, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">31.0±12.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26.6±11.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">RS apex, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14.8±5.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.5±12.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CS basal, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-26.2±5.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-22.4±2.8<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; 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Uçar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Thromb Res" "fecha" => "2020" "volumen" => "189" "paginaInicial" => "102" "paginaFinal" => "107" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0070" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Left ventricular rotational abnormalities in hemophilia – insights from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Nemes" 1 => "Á. Kormányos" 2 => "P. Domsik" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.21037/qims-21-30" "Revista" => array:6 [ "tituloSerie" => "Quant Imaging Med Surg" "fecha" => "2022" "volumen" => "12" "paginaInicial" => "886" "paginaFinal" => "893" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35111591" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/08702551/0000004100000005/v1_202205200629/S0870255122000646/v1_202205200629/en/main.assets" "Apartado" => array:4 [ "identificador" => "93625" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/08702551/0000004100000005/v1_202205200629/S0870255122000646/v1_202205200629/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122000646?idApp=UINPBA00004E"]

Estatísticas

Letter to the Editor

Deformação miocárdica ventricular esquerda na hemofilia (do estudo MAGYAR-Path)

Attila Nemesa,

Autor para correspondência

nemes.attila@med.u-szeged.hu

Corresponding author.

, Árpád Kormányosa, Klára Vezendib,c, Imelda Martonb,c, Zita Borbényib

a Department of Medicine, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary

b Division of Haematology, Department of Medicine, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary

c Department of Transfusiology, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary

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    "titulo" => "Left ventricular deformation in hemophilia &#40;from the MAGYAR-Path Study&#41;"
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        "titulo" => "Deforma&#231;&#227;o mioc&#225;rdica ventricular esquerda na hemofilia &#40;do estudo MAGYAR-Path&#41;"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Images from three-dimensional &#40;3D&#41; speckle-tracking echocardiographic analysis in apical 4-chamber view &#40;A&#41;&#44; apical 2-chamber view &#40;B&#41; and apical &#40;C3&#41;&#44; mid-ventricular &#40;C5&#41; and basal &#40;C7&#41; left ventricular &#40;LV&#41; short-axis views together with a 3D virtual model of the LV &#40;red D&#41;&#44; LV volumetric data on the cardiac cycle &#40;red E&#41; and time &#8211; LV segmental and global strain curves &#40;colored lines&#41; with a time &#8211; LV volume changes curve &#40;dashed line&#41; during the cardiac cycle &#40;red F&#41;&#46; LA&#58; left atrium&#59; LV&#58; left ventricle&#59; RA&#58; right atrium&#59; RV&#58; right ventricle&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Hemophilia is the most common severe coagulation disorder &#40;deficiency of factor VIII causing type A and deficiency of factor IX causing type B&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> Hemophilia-related changes in left ventricular &#40;LV&#41; function have been little examined&#46; Three-dimensional &#40;3D&#41; speckle-tracking echocardiography &#40;3DSTE&#41; can provide detailed assessment of LV contractility represented by LV strains&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2&#44;3</span></a> The present study was designed to compare 3DSTE-derived LV strains between patients with hemophilia and matched controls&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The study analyzed 16 male patients with hemophilia&#44; three of whom were excluded due to insufficient image quality&#46; Eleven patients had hemophilia A&#44; while two had hemophilia B&#46; Mean age was 42&#46;1&#177;19&#46;5 years&#46; Hypertension&#44; hypercholesterolemia&#44; diabetes mellitus&#44; HCV positivity and hemophilic arthropathy were present in five&#44; three&#44; two&#44; nine and eight patients&#44; respectively&#46; All patients were treated with a 1000-6000 U&#47;week dose of factors for each patient&#46; Their results were compared to those of 15 healthy male controls with a mean age of 46&#46;3&#177;6&#46;0 years&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Complete two-dimensional Doppler echocardiography &#40;2DDE&#41; and 3DSTE were performed in all hemophilia patients and controls&#46; Results are from the MAGYAR-Path &#40;Motion Analysis of the heart and Great vessels bY three-dimensionAl speckle-tRacking echocardiography in Pathological cases&#41; Study&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> The institutional ethics committee at the University of Szeged approved the study&#44; which complied with the 1975 Declaration of Helsinki &#40;and updated versions&#41; and all hemophilia patients and controls gave informed consent&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">2DDE and 3DSTE were performed on a Toshiba Artida cardiac ultrasound system using a broadband 1-5 MHz PST-30SBP phased array transducer and a PST-25SX matrix array transducer &#40;Toshiba Medical Systems&#44; Tokyo&#44; Japan&#41;&#44; respectively&#46; 2DDE-derived chamber quantifications and Doppler assessments were performed according to the guidelines&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2&#44;3</span></a> 3DSTE was performed according to recent practice with offline analysis by 3D Wall Motion Tracking software as detailed previously&#46; Global&#44; mean segmental and regional LV strains in longitudinal &#40;LS&#41;&#44; circumferential &#40;CS&#41; and radial &#40;RS&#41; directions were calculated&#46; Combined strains &#40;area strain&#44; AS&#44; and 3D strain&#44; 3DS&#41; were also measured &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">3&#44;4</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">2DDE data did not differ between hemophilia patients and controls &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Doppler echocardiography did not identify grade &#8805;1 valvular regurgitation or valvular stenosis in any patients or controls&#46; 3DSTE-derived global and mean segmental LV strains did not show differences between groups&#44; while only regional basal and midventricular LV circumferential strains &#40;CSs&#41; were significantly reduced in patients with hemophilia compared to healthy controls &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">In a recent study&#44; higher probability of cardiac disease&#44; LV systolic dysfunction&#44; coronary artery disease&#47;microvascular disease&#44; and LV electrical remodeling were detected in patients with hemophilia A compared to matched controls&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> Moreover&#44; impaired myocardial LV systolic function represented by increased myocardial performance index has also been demonstrated&#44; related to arterial stiffness&#44; in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> Although the number of hemophilia patients examined in the present study was small&#44; significant reductions in 3DSTE-derived regional LV CSs were observed&#46; No global&#44; mean segmental or other regional LV strains differed between the groups examined&#46; This finding appears to be important in the context of previous results including reduced apical LV rotation and twist in hemophilia&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> Regional LV deformation abnormalities in hemophilia could be explained by various factors including hemophilia-related increased aortic stiffness&#44; altered blood quality&#44; accompanying risk factors&#44; and others&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> However&#44; further studies are warranted to confirm these findings&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">40&#46;0&#177;4&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">38&#46;6&#177;3&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">47&#46;9&#177;3&#46;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;04&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">108&#46;0&#177;20&#46;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">32&#46;2&#177;2&#46;6&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>RS mid&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">31&#46;0&#177;12&#46;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">26&#46;6&#177;11&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>RS apex&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16&#46;5&#177;12&#46;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CS basal&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CS mid&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">-24&#46;5&#177;4&#46;6<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CS apex&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">-26&#46;2&#177;8&#46;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">-30&#46;0&#177;10&#46;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>LS basal&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">-19&#46;1&#177;4&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>LS mid&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">-13&#46;1&#177;4&#46;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">-12&#46;6&#177;4&#46;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">-15&#46;0&#177;4&#46;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">-19&#46;6&#177;7&#46;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">34&#46;7&#177;13&#46;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3DS mid&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">32&#46;3&#177;11&#46;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">27&#46;8&#177;10&#46;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3DS apex&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">17&#46;1&#177;6&#46;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">17&#46;7&#177;12&#46;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>AS basal&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>AS mid&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">-38&#46;4&#177;6&#46;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">-34&#46;7&#177;6&#46;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>AS apex&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">-38&#46;5&#177;10&#46;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">-44&#46;4&#177;13&#46;0&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Comparison of three-dimensional speckle-tracking echocardiography-derived global and mean segmental left ventricular peak strains between hemophilia patients and controls&#46;</p>"
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                      "titulo" => "Three-dimensional speckle-tracking echocardiography &#8211; a further step in non-invasive three-dimensional cardiac imaging"
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                      "titulo" => "Active acromegaly is associated with enhanced left ventricular contractility&#58; results from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path study"
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Informação do artigo

ISSN: 08702551
Idioma original: Inglês

DOI:10.1016/j.repc.2021.07.012

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