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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Coronary angiography after multiple percutaneous coronary artery revascularizations &#40;A&#44; &#42;&#41; showing chronic occlusion of the posterior descending artery &#40;B&#44; arrowhead&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The present report concerns a 54-year-old man with refractory angina who was referred for lipoprotein&#40;a&#41; &#91;Lp&#40;a&#41;&#93; apheresis &#40;LA&#41; because of Lp&#40;a&#41;-hyperlipoproteinemia&#46; At 18-month follow-up&#44; myocardial perfusion&#44; assessed with stress cardiac magnetic resonance&#44; was shown to improve&#44; with progressive amelioration of anginal symptoms&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient began to suffer effort angina at the age of 53&#46; In one year he had undergone multiple percutaneous coronary artery revascularizations&#44; with chronic occlusion of the posterior descending artery &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46; At his first admission to our lipid clinic&#44; he was diagnosed with Lp&#40;a&#41;-hyperlipoproteinemia and polygenic hypercholesterolemia&#46; He was receiving ranolazine 750 mg twice daily&#44; aspirin 100 mg once daily&#44; clopidogrel 75 mg once daily&#44; and irbesartan 300 mg once daily&#46; In the 6-min walk test angina appeared at 450 m&#59; a baseline Seattle Angina Questionnaire &#40;SAQ&#41;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> was recorded&#46; Carotid artery Doppler examination revealed intimal medial thickness &#60;1 mm with 30&#37; stenosis at the sinus bilaterally&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Considering the role of Lp&#40;a&#41;-hyperlipoproteinemia in the pathogenesis of refractory angina&#44; LA was started<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a> and was repeated every two weeks&#44; treating 5000 ml of plasma &#40;about 2&#46;0 times patient plasma volume&#41; per session using dextran sulfate &#40;Liposorber&#174; LA systems&#59; Kaneka&#41; in addition to optimized lipid-lowering therapy &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Background pharmacological therapy was maintained unchanged&#46; During 18 months of follow-up the patient presented progressive improvement in anginal symptoms&#58; effort angina in the 6-min walk test regressed and an improvement in four of five domains of the SAQ was reported&#46; The follow-up myocardial perfusion scan on stress cardiac magnetic resonance imaging showed improvement in the septal left ventricular wall perfusion defect and resolution of the lateral left ventricular wall perfusion defect &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Refractory angina is a growing problem worldwide due to improved survival after revascularization procedures&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3&#44;4</span></a> The case reported supports the hypothesis that Lp&#40;a&#41;-hyperlipoproteinemia is a contributing factor in refractory angina&#58; the apolipoprotein&#40;a&#41; &#91;apo&#40;a&#41;&#93; component of Lp&#40;a&#41; exhibits structural homology with plasminogen&#44; enhances thrombosis and impairs fibrinolysis&#46; Reduction of Lp&#40;a&#41; by LA improves thrombotic and fibrinolytic parameters in patients with refractory angina&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a> enables restoration of endothelial function&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a> and reduces the incidence of cardiovascular events in patients with Lp&#40;a&#41;-hyperlipoproteinemia&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> In addition&#44; a unified view of Lp&#40;a&#41; in cardiovascular medicine draws attention to the advantages of associating cascade screening with personalized therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Until apo&#40;a&#41; antisense therapy becomes available&#44; LA may represent an effective long-term treatment for refractory angina in those with Lp&#40;a&#41;-hyperlipoproteinemia that may improve myocardial perfusion&#44; angina symptoms and quality of life&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0030" class="elsevierStylePara elsevierViewall">No financial support was received&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">153&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">167&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">120&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Atorvastatin 40 mg once daily&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Before LA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">117&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Rosuvastatin 10 mg once dailyFenofibrate 145 mg once dailyAcipimox 500 mg once daily&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Rosuvastatin 10 mg once dailyFenofibrate 145 mg once dailyAcipimox 500 mg once daily&nbsp;\t\t\t\t\t\t\n
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Letter to the Editor
Lipoprotein(a) apheresis restores coronary microcirculation in refractory angina
A aférese da lipoproteinemia (a) restaura a microcirculação coronária na angina refratária
Francesco Sbranaa,
Autor para correspondência
francesco.sbrana@ftgm.it

Corresponding author.
, Beatrice Dal Pinoa, Giovanni Donato Aquarob, Federico Bigazzia, Giuseppe Vergaroc, Tiziana Sampietroa
a Lipoapheresis Unit, Reference Center for Diagnosis and Treatment of Inherited Dyslipidemias, Fondazione Toscana “Gabriele Monasterio”, Pisa, Italy
b Magnetic Resonance Imaging Unit, Fondazione Toscana “Gabriele Monasterio”, Pisa, Italy
c U.O. Cardiologia e Medicina Cardiovascolare, Fondazione Toscana “Gabriele Monasterio”, Pisa, Italy
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    "titulo" => "Lipoprotein&#40;a&#41; apheresis restores coronary microcirculation in refractory angina"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Coronary angiography after multiple percutaneous coronary artery revascularizations &#40;A&#44; &#42;&#41; showing chronic occlusion of the posterior descending artery &#40;B&#44; arrowhead&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The present report concerns a 54-year-old man with refractory angina who was referred for lipoprotein&#40;a&#41; &#91;Lp&#40;a&#41;&#93; apheresis &#40;LA&#41; because of Lp&#40;a&#41;-hyperlipoproteinemia&#46; At 18-month follow-up&#44; myocardial perfusion&#44; assessed with stress cardiac magnetic resonance&#44; was shown to improve&#44; with progressive amelioration of anginal symptoms&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient began to suffer effort angina at the age of 53&#46; In one year he had undergone multiple percutaneous coronary artery revascularizations&#44; with chronic occlusion of the posterior descending artery &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46; At his first admission to our lipid clinic&#44; he was diagnosed with Lp&#40;a&#41;-hyperlipoproteinemia and polygenic hypercholesterolemia&#46; He was receiving ranolazine 750 mg twice daily&#44; aspirin 100 mg once daily&#44; clopidogrel 75 mg once daily&#44; and irbesartan 300 mg once daily&#46; In the 6-min walk test angina appeared at 450 m&#59; a baseline Seattle Angina Questionnaire &#40;SAQ&#41;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> was recorded&#46; Carotid artery Doppler examination revealed intimal medial thickness &#60;1 mm with 30&#37; stenosis at the sinus bilaterally&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Considering the role of Lp&#40;a&#41;-hyperlipoproteinemia in the pathogenesis of refractory angina&#44; LA was started<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a> and was repeated every two weeks&#44; treating 5000 ml of plasma &#40;about 2&#46;0 times patient plasma volume&#41; per session using dextran sulfate &#40;Liposorber&#174; LA systems&#59; Kaneka&#41; in addition to optimized lipid-lowering therapy &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Background pharmacological therapy was maintained unchanged&#46; During 18 months of follow-up the patient presented progressive improvement in anginal symptoms&#58; effort angina in the 6-min walk test regressed and an improvement in four of five domains of the SAQ was reported&#46; The follow-up myocardial perfusion scan on stress cardiac magnetic resonance imaging showed improvement in the septal left ventricular wall perfusion defect and resolution of the lateral left ventricular wall perfusion defect &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Refractory angina is a growing problem worldwide due to improved survival after revascularization procedures&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3&#44;4</span></a> The case reported supports the hypothesis that Lp&#40;a&#41;-hyperlipoproteinemia is a contributing factor in refractory angina&#58; the apolipoprotein&#40;a&#41; &#91;apo&#40;a&#41;&#93; component of Lp&#40;a&#41; exhibits structural homology with plasminogen&#44; enhances thrombosis and impairs fibrinolysis&#46; Reduction of Lp&#40;a&#41; by LA improves thrombotic and fibrinolytic parameters in patients with refractory angina&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a> enables restoration of endothelial function&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a> and reduces the incidence of cardiovascular events in patients with Lp&#40;a&#41;-hyperlipoproteinemia&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> In addition&#44; a unified view of Lp&#40;a&#41; in cardiovascular medicine draws attention to the advantages of associating cascade screening with personalized therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Until apo&#40;a&#41; antisense therapy becomes available&#44; LA may represent an effective long-term treatment for refractory angina in those with Lp&#40;a&#41;-hyperlipoproteinemia that may improve myocardial perfusion&#44; angina symptoms and quality of life&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0030" class="elsevierStylePara elsevierViewall">No financial support was received&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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                  \t\t\t\t">Before LA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">117&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rosuvastatin 10 mg once dailyFenofibrate 145 mg once dailyAcipimox 500 mg once daily&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">After LA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rosuvastatin 10 mg once dailyFenofibrate 145 mg once dailyAcipimox 500 mg once daily&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                      "titulo" => "Reduced incidence of cardiovascular events in hyper-Lp&#40;a&#41; patients on lipoprotein apheresis&#46; The G&#46;I&#46;L&#46;A&#46; &#40;Gruppo Interdisciplinare Aferesi Lipoproteica&#41; pilot study"
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                      "titulo" => "Lipoprotein&#40;a&#41; in familial hypercholesterolemia&#58; tips from family history"
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