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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Sinus of Valsalva aneurysm &#40;SVA&#41; is a rare condition affecting 3&#37; of Asian and &#60;1&#37; of Western patients undergoing cardiac surgery&#44; with a 4&#58;1 male predominance&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Etiology is either congenital or acquired secondary to infective endocarditis&#44; syphilis&#44; atherosclerosis&#44; Marfan syndrome&#44; autoimmune diseases or chest trauma&#46; Aneurysms arising from the right sinus are the most common&#44; usually rupturing into the right ventricle&#46; Nearly 50&#37; of SVAs coexist with a long-standing primary ventricular septal defect &#40;VSD&#41;&#44; most often supracristal&#46; Rupture typically occurs in the mid-thirties&#44; with variable severity of symptom onset according to size&#44; location&#44; associated lesions and acuity of the rupture&#46; If left untreated&#44; right ventricular overload and pulmonary arterial hypertension &#40;PAH&#41; develop&#44; with a grim prognosis &#40;one-year life expectancy&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> While surgery remains the mainstay treatment for ruptured SVA&#44; percutaneous treatment has emerged as a valid alternative for selected patients&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 39-year-old man presented with a two-month history of worsening dyspnea and rapidly progressive orthopnea&#44; in New York Heart Association &#40;NYHA&#41; functional class III&#46; Physical examination revealed a continuous systolic-diastolic murmur in the pulmonary area and raised jugular venous pressure&#44; but no cyanosis&#46; The electrocardiogram showed sinus tachycardia with right bundle branch block&#44; and the chest X-ray revealed cardiomegaly with pulmonary venous congestion&#46; Transthoracic echocardiography &#40;TTE&#41; revealed right-sided volume overload with right ventricular enlargement &#40;45 mm&#41;&#44; dilated pulmonary trunk &#40;38 mm&#41; with near-systemic PAH &#40;&#62;90 mmHg&#41;&#44; and the presence of a perimembranous ventricular septal defect &#40;VSD&#41;&#44; with normal left ventricular size and function &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>A&#41;&#46; Transesophageal echocardiography &#40;TEE&#41; confirmed the presence of a 3-mm perimembranous VSD with bidirectional shunting &#40;predominantly right-to-left&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>B&#41;&#44; while also revealing a 7-mm right SVA ruptured into the right ventricular outflow tract adjacent to the pulmonary valve &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>C&#41;&#46; Following multidisciplinary heart team discussion and considering the anatomical suitability of the rupture opening for a transcatheter approach &#40;moderate sized defect&#44; optimal proximal and distal margins&#44; no associated aortic regurgitation&#41;&#44; the patient was referred for transcatheter ruptured SVA closure&#44; after prior balloon test occlusion to assess PAH reversibility&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The procedure was performed under fluoroscopic and TEE guidance&#44; using a retrograde approach&#44; under intravenous heparin &#40;80 U&#47;kg&#41; and antibiotic cover &#40;cefazolin&#41;&#46; A Swan-Ganz thermodilution catheter was inserted through the right cephalic vein&#46; Baseline invasively determined pressures showed suprasystemic PAH with a mean pulmonary pressure of 59 mmHg and a mean aortic pressure of 50 mmHg&#46; A pigtail catheter for aortography was advanced from the left femoral artery&#46; Through right femoral arterial access&#44; the SVA defect was crossed retrogradely from the aorta into the right ventricular outflow tract with a Judkins right catheter &#40;Cordis Corp&#46;&#44; Miami&#44; FL&#41;&#44; which was exchanged for a Mullins sheath &#40;Cook Inc&#46;&#44; Bloomington&#44; IN&#41; through a stiff exchange wire&#46; A 10&#47;5-mm Amplatzer Vascular Plug III &#40;Abbott Vascular&#44; Santa Clara&#44; CA&#41; was first advanced through the Mullins sheath to occlude the ruptured SVA for 30 min with incomplete shunt sealing&#44; and thereafter replaced by a 12-mm Amplatzer Muscular VSD device&#44; resulting in successful shunt occlusion &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>A&#41;&#46; Rapid hemodynamic improvement was seen during the transient occlusion test&#44; with a marked reduction in mean pulmonary pressure &#40;from 59 to 49 mmHg&#41;&#44; increase in mean aortic pressure &#40;from 50 to 73 mmHg&#41;&#44; and normalization of oxygen saturation &#40;SpO<span class="elsevierStyleInf">2</span> at 4 l&#47;min from 86&#37; to 100&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; After confirmation of the suitability for closure of the ruptured SVA&#44; the 12-mm Amplatzer Muscular VSD device was released&#44; with minimal residual peri-device leak&#44; no aortic regurgitation and inversion of the VSD shunt &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>B&#41;&#46; The small VSD was considered hemodynamically insignificant &#40;restrictive&#41; and was therefore untreated&#46; The patient was discharged with no complications on dual antiplatelet therapy for six months&#44; and under sildenafil 20 mg&#47;8 h and furosemide 20 mg&#47;24 h&#46; At one-year follow-up&#44; the patient remained without events&#44; in NYHA functional class I&#44; with minimal resting left-to-right shunt&#44; and complete regression of suprasystemic PAH&#44; allowing discontinuation of furosemide and sildenafil &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>C&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">The present case demonstrates the reversal of severe flow-mediated PAH related to systemic-to-pulmonary shunting with pulmonary overcirculation following transcatheter closure of a ruptured SVA into the right ventricle&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">SVA are generally silent until rupture into a cardiac chamber&#46; In our patient with concomitant SVA and VSD&#44; the right coronary cusp aneurysm probably occluded the VSD until the sinus ruptured into the right ventricle&#44; resulting in a large systemic-to-pulmonary shunt through the ruptured SVA and causing systemic systolic pressure overload in the pulmonary artery and systemic diastolic pressure and volume overload in the right ventricle&#44; with predominant right-to-left shunting through the VSD and desaturation&#46; Interestingly&#44; closure of the ruptured SVA led to resolution of the aortocardiac shunt&#44; with inversion of the VSD shunt to left-to-right shunting and normalization of saturation&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The degree of reversibility of the pulmonary circulation can be assessed using short-acting pulmonary vasodilators&#44; or through transient balloon test occlusion&#44; particularly in patients with persistently elevated pulmonary vascular resistance despite a positive response to vasodilators&#44; and those with bidirectional shunting&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> Although somewhat arbitrary&#44; a drop in pulmonary pressures of &#8764;20&#37; without a significant decrease in systemic pressure during test occlusion would suggest a high likelihood of benefiting from permanent closure&#46; Closure of cardiac shunts is generally not recommended when pulmonary artery pressures are &#62;2&#47;3 of systemic values&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> due to increased risk of sustained PAH&#44; right heart failure and hypertensive crisis immediately after closure&#46; However&#44; the rationale for closure in our patient was the subacute onset of symptoms leading to rapid clinical deterioration and the presence of bidirectional shunting through the VSD&#44; along with marked hemodynamic improvement after the transient occlusion test&#44; making the hypothesis of fixed &#40;irreversible&#41; PAH highly unlikely&#44; and thus highlighting a potential benefit from permanent shunt closure&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In recent years&#44; percutaneous closure of ruptured SVAs has emerged as a valid alternative to surgery&#46; Although direct comparisons between the two approaches have been somewhat limited by selection bias &#40;more severe aortic regurgitation and more complex associated lesions in patients undergoing surgery&#41;&#44; transcatheter closure of ruptured SVAs has been shown to be safe and effective&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Suitability for percutaneous closure of intracardiac communications with associated PAH relies on anatomic features &#8211; magnitude of the shunt&#44; presence of adequate rim to secure the device &#8211; and potential for PAH reversal&#46; In our patient&#44; three-dimensional TEE was crucial to precisely delineate two closely adjacent congenital defects&#44; the shunt flows of which overlapped on TTE&#44; showing anatomical suitability for percutaneous closure of the ruptured SVA&#46; Although lacking solid scientific evidence&#44; transcatheter closure of a ruptured SVA might be a reasonable option for patients with a rupture opening of less than 9 mm&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> in the absence of secondary complications &#40;fistulous ruptured SVA or multiple rupture sites&#44; significant aortic regurgitation&#41; or pre-existing conditions requiring surgical correction &#40;endocarditis&#44; large VSD or other complex congenital defects&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Of note&#44; large lesions &#40;&#62;12 mm&#41; should prompt preprocedural multimodality imaging assessment &#40;including computed tomography or magnetic resonance imaging&#41; to elucidate the best therapeutic approach&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Most importantly&#44; while transcatheter occlusion of ruptured SVAs has emerged as a well-established alternative to surgical closure for highly selected patients&#44; caution is warranted in the setting of associated severe PAH&#46; Transient occlusion testing during cardiac catheterization is critical in determining the safety of permanent shunt closure&#44; enabling differentiation between dynamic PAH and irreversible obstructive PAH&#44; and providing reliable assessment of the reversibility of pulmonary vascular disease&#46; To our knowledge&#44; this is the first case report of suprasystemic flow-induced PAH regression following percutaneous closure of a ruptured SVA&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">O tratamento de pacientes com defeitos card&#237;acos cong&#233;nitos e hipertens&#227;o pulmonar associada continua a ser um importante motivo de preocupa&#231;&#227;o&#46; Com o desenvolvimento de estrat&#233;gias farmacol&#243;gicas dirigidas e novos dispositivos transcat&#233;ter&#44; o tratamento de pacientes selecionados com hipertens&#227;o pulmonar grave&#44; tradicionalmente considerados inoper&#225;veis&#44; tornou-se vi&#225;vel&#46; Apresentamos o caso de um paciente com aneurisma do seio de Valsalva direito roto e defeito do septo ventricular&#44; com r&#225;pida revers&#227;o das press&#245;es pulmonares suprassist&#234;micas ap&#243;s encerramento percut&#226;neo do seio de Valsalva roto&#46;</p></span>"
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                      "titulo" => "Ruptured aneurysms of the sinus of Valsalva in oriental patients"
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                        "tituloSerie" => "J Thorac Cardiovasc Surg"
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                      "titulo" => "Congenital aneurysms of sinus of Valsalva&#46; A clinical study"
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                        "fecha" => "1962"
                        "volumen" => "63"
                        "paginaInicial" => "708"
                        "paginaFinal" => "719"
                        "link" => array:1 [
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                      "titulo" => "Evaluating operability in adults with congenital heart disease and the role of pretreatment with targeted pulmonary arterial hypertension therapy"
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                      "doi" => "10.1016/j.ijcard.2008.02.004"
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                        "tituloSerie" => "Int J Cardiol"
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Case report
Ruptured sinus of Valsalva aneurysm: A reversible cause of suprasystemic pulmonary hypertension
Shunt cardíaco e hipertensão pulmonar: uma associação preocupante mas corrigível
Lluis Asmaratsa,b,
Autor para correspondência
luis_asmarats@hotmail.com

Corresponding author.
, Armando Bethencourtc, Antonio Rodrígueza, Marta Norisa, Jaume Maristanya, Andrés Graua, Alfredo Gómez-Jaumea, Vicente Perala
a Department of Cardiology, Hospital Universitari Son Espases, Palma, Spain
b Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
c Department of Cardiology, Hospital Quirón Palmaplanas, Palma, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Sinus of Valsalva aneurysm &#40;SVA&#41; is a rare condition affecting 3&#37; of Asian and &#60;1&#37; of Western patients undergoing cardiac surgery&#44; with a 4&#58;1 male predominance&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Etiology is either congenital or acquired secondary to infective endocarditis&#44; syphilis&#44; atherosclerosis&#44; Marfan syndrome&#44; autoimmune diseases or chest trauma&#46; Aneurysms arising from the right sinus are the most common&#44; usually rupturing into the right ventricle&#46; Nearly 50&#37; of SVAs coexist with a long-standing primary ventricular septal defect &#40;VSD&#41;&#44; most often supracristal&#46; Rupture typically occurs in the mid-thirties&#44; with variable severity of symptom onset according to size&#44; location&#44; associated lesions and acuity of the rupture&#46; If left untreated&#44; right ventricular overload and pulmonary arterial hypertension &#40;PAH&#41; develop&#44; with a grim prognosis &#40;one-year life expectancy&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> While surgery remains the mainstay treatment for ruptured SVA&#44; percutaneous treatment has emerged as a valid alternative for selected patients&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 39-year-old man presented with a two-month history of worsening dyspnea and rapidly progressive orthopnea&#44; in New York Heart Association &#40;NYHA&#41; functional class III&#46; Physical examination revealed a continuous systolic-diastolic murmur in the pulmonary area and raised jugular venous pressure&#44; but no cyanosis&#46; The electrocardiogram showed sinus tachycardia with right bundle branch block&#44; and the chest X-ray revealed cardiomegaly with pulmonary venous congestion&#46; Transthoracic echocardiography &#40;TTE&#41; revealed right-sided volume overload with right ventricular enlargement &#40;45 mm&#41;&#44; dilated pulmonary trunk &#40;38 mm&#41; with near-systemic PAH &#40;&#62;90 mmHg&#41;&#44; and the presence of a perimembranous ventricular septal defect &#40;VSD&#41;&#44; with normal left ventricular size and function &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>A&#41;&#46; Transesophageal echocardiography &#40;TEE&#41; confirmed the presence of a 3-mm perimembranous VSD with bidirectional shunting &#40;predominantly right-to-left&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>B&#41;&#44; while also revealing a 7-mm right SVA ruptured into the right ventricular outflow tract adjacent to the pulmonary valve &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>C&#41;&#46; Following multidisciplinary heart team discussion and considering the anatomical suitability of the rupture opening for a transcatheter approach &#40;moderate sized defect&#44; optimal proximal and distal margins&#44; no associated aortic regurgitation&#41;&#44; the patient was referred for transcatheter ruptured SVA closure&#44; after prior balloon test occlusion to assess PAH reversibility&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The procedure was performed under fluoroscopic and TEE guidance&#44; using a retrograde approach&#44; under intravenous heparin &#40;80 U&#47;kg&#41; and antibiotic cover &#40;cefazolin&#41;&#46; A Swan-Ganz thermodilution catheter was inserted through the right cephalic vein&#46; Baseline invasively determined pressures showed suprasystemic PAH with a mean pulmonary pressure of 59 mmHg and a mean aortic pressure of 50 mmHg&#46; A pigtail catheter for aortography was advanced from the left femoral artery&#46; Through right femoral arterial access&#44; the SVA defect was crossed retrogradely from the aorta into the right ventricular outflow tract with a Judkins right catheter &#40;Cordis Corp&#46;&#44; Miami&#44; FL&#41;&#44; which was exchanged for a Mullins sheath &#40;Cook Inc&#46;&#44; Bloomington&#44; IN&#41; through a stiff exchange wire&#46; A 10&#47;5-mm Amplatzer Vascular Plug III &#40;Abbott Vascular&#44; Santa Clara&#44; CA&#41; was first advanced through the Mullins sheath to occlude the ruptured SVA for 30 min with incomplete shunt sealing&#44; and thereafter replaced by a 12-mm Amplatzer Muscular VSD device&#44; resulting in successful shunt occlusion &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>A&#41;&#46; Rapid hemodynamic improvement was seen during the transient occlusion test&#44; with a marked reduction in mean pulmonary pressure &#40;from 59 to 49 mmHg&#41;&#44; increase in mean aortic pressure &#40;from 50 to 73 mmHg&#41;&#44; and normalization of oxygen saturation &#40;SpO<span class="elsevierStyleInf">2</span> at 4 l&#47;min from 86&#37; to 100&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; After confirmation of the suitability for closure of the ruptured SVA&#44; the 12-mm Amplatzer Muscular VSD device was released&#44; with minimal residual peri-device leak&#44; no aortic regurgitation and inversion of the VSD shunt &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>B&#41;&#46; The small VSD was considered hemodynamically insignificant &#40;restrictive&#41; and was therefore untreated&#46; The patient was discharged with no complications on dual antiplatelet therapy for six months&#44; and under sildenafil 20 mg&#47;8 h and furosemide 20 mg&#47;24 h&#46; At one-year follow-up&#44; the patient remained without events&#44; in NYHA functional class I&#44; with minimal resting left-to-right shunt&#44; and complete regression of suprasystemic PAH&#44; allowing discontinuation of furosemide and sildenafil &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>C&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">The present case demonstrates the reversal of severe flow-mediated PAH related to systemic-to-pulmonary shunting with pulmonary overcirculation following transcatheter closure of a ruptured SVA into the right ventricle&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">SVA are generally silent until rupture into a cardiac chamber&#46; In our patient with concomitant SVA and VSD&#44; the right coronary cusp aneurysm probably occluded the VSD until the sinus ruptured into the right ventricle&#44; resulting in a large systemic-to-pulmonary shunt through the ruptured SVA and causing systemic systolic pressure overload in the pulmonary artery and systemic diastolic pressure and volume overload in the right ventricle&#44; with predominant right-to-left shunting through the VSD and desaturation&#46; Interestingly&#44; closure of the ruptured SVA led to resolution of the aortocardiac shunt&#44; with inversion of the VSD shunt to left-to-right shunting and normalization of saturation&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The degree of reversibility of the pulmonary circulation can be assessed using short-acting pulmonary vasodilators&#44; or through transient balloon test occlusion&#44; particularly in patients with persistently elevated pulmonary vascular resistance despite a positive response to vasodilators&#44; and those with bidirectional shunting&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> Although somewhat arbitrary&#44; a drop in pulmonary pressures of &#8764;20&#37; without a significant decrease in systemic pressure during test occlusion would suggest a high likelihood of benefiting from permanent closure&#46; Closure of cardiac shunts is generally not recommended when pulmonary artery pressures are &#62;2&#47;3 of systemic values&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> due to increased risk of sustained PAH&#44; right heart failure and hypertensive crisis immediately after closure&#46; However&#44; the rationale for closure in our patient was the subacute onset of symptoms leading to rapid clinical deterioration and the presence of bidirectional shunting through the VSD&#44; along with marked hemodynamic improvement after the transient occlusion test&#44; making the hypothesis of fixed &#40;irreversible&#41; PAH highly unlikely&#44; and thus highlighting a potential benefit from permanent shunt closure&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In recent years&#44; percutaneous closure of ruptured SVAs has emerged as a valid alternative to surgery&#46; Although direct comparisons between the two approaches have been somewhat limited by selection bias &#40;more severe aortic regurgitation and more complex associated lesions in patients undergoing surgery&#41;&#44; transcatheter closure of ruptured SVAs has been shown to be safe and effective&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Suitability for percutaneous closure of intracardiac communications with associated PAH relies on anatomic features &#8211; magnitude of the shunt&#44; presence of adequate rim to secure the device &#8211; and potential for PAH reversal&#46; In our patient&#44; three-dimensional TEE was crucial to precisely delineate two closely adjacent congenital defects&#44; the shunt flows of which overlapped on TTE&#44; showing anatomical suitability for percutaneous closure of the ruptured SVA&#46; Although lacking solid scientific evidence&#44; transcatheter closure of a ruptured SVA might be a reasonable option for patients with a rupture opening of less than 9 mm&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> in the absence of secondary complications &#40;fistulous ruptured SVA or multiple rupture sites&#44; significant aortic regurgitation&#41; or pre-existing conditions requiring surgical correction &#40;endocarditis&#44; large VSD or other complex congenital defects&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Of note&#44; large lesions &#40;&#62;12 mm&#41; should prompt preprocedural multimodality imaging assessment &#40;including computed tomography or magnetic resonance imaging&#41; to elucidate the best therapeutic approach&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Most importantly&#44; while transcatheter occlusion of ruptured SVAs has emerged as a well-established alternative to surgical closure for highly selected patients&#44; caution is warranted in the setting of associated severe PAH&#46; Transient occlusion testing during cardiac catheterization is critical in determining the safety of permanent shunt closure&#44; enabling differentiation between dynamic PAH and irreversible obstructive PAH&#44; and providing reliable assessment of the reversibility of pulmonary vascular disease&#46; To our knowledge&#44; this is the first case report of suprasystemic flow-induced PAH regression following percutaneous closure of a ruptured SVA&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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            0 => "Aneurisma do seio de Valsalva"
            1 => "Hipertens&#227;o pulmonar"
            2 => "Encerramento percut&#226;neo"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Management of patients with congenital heart defects and associated pulmonary arterial hypertension remains a major concern&#46; With evolving targeted drug therapies and new iterations of transcatheter devices&#44; treatment of appropriately selected patients with severe pulmonary hypertension&#44; classically considered inoperable&#44; has become feasible&#46; We report the case of a patient with concomitant ruptured right sinus of Valsalva aneurysm and ventricular septal defect&#44; with early reversal of suprasystemic pulmonary pressures following successful percutaneous closure of ruptured sinus of Valsalva&#46;</p></span>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">O tratamento de pacientes com defeitos card&#237;acos cong&#233;nitos e hipertens&#227;o pulmonar associada continua a ser um importante motivo de preocupa&#231;&#227;o&#46; Com o desenvolvimento de estrat&#233;gias farmacol&#243;gicas dirigidas e novos dispositivos transcat&#233;ter&#44; o tratamento de pacientes selecionados com hipertens&#227;o pulmonar grave&#44; tradicionalmente considerados inoper&#225;veis&#44; tornou-se vi&#225;vel&#46; Apresentamos o caso de um paciente com aneurisma do seio de Valsalva direito roto e defeito do septo ventricular&#44; com r&#225;pida revers&#227;o das press&#245;es pulmonares suprassist&#234;micas ap&#243;s encerramento percut&#226;neo do seio de Valsalva roto&#46;</p></span>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Transthoracic echocardiography showing a perimembranous ventricular septal defect &#40;VSD&#44; asterisk&#41; with severe pulmonary hypertension&#59; &#40;B&#41; two- and three-dimensional transesophageal echocardiography confirming VSD with bidirectional shunting&#44; and unmasking a circular rupture opening of the right sinus of Valsalva aneurysm &#40;6&#46;5 mm&#215;6&#46;7<span class="elsevierStyleHsp" style=""></span>mm&#44; arrow&#41; into the right ventricular outflow tract &#40;C&#41;&#46;</p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Fluoroscopic and echocardiographic images of the ruptured sinus of Valsalva aneurysm &#40;arrow&#41; during transient percutaneous occlusion testing &#40;A&#41; and after definitive closure &#40;B&#41; with the 12-mm Amplatzer Muscular VSD device&#44; with trace peri-device leak and trivial left-to-right shunt through the VSD&#59; &#40;C&#41; one-year echocardiographic follow-up showing appropriate apposition and sealing of the device and absence of pulmonary hypertension&#46;</p>"
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                    0 => array:2 [
                      "titulo" => "Ruptured aneurysms of the sinus of Valsalva in oriental patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;H&#46; Chu"
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                        "tituloSerie" => "J Thorac Cardiovasc Surg"
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                    0 => array:2 [
                      "titulo" => "Congenital aneurysms of sinus of Valsalva&#46; A clinical study"
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                        0 => array:2 [
                          "etal" => false
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                    0 => array:2 [
                      "doi" => "10.1016/0002-8703(62)90018-2"
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                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1962"
                        "volumen" => "63"
                        "paginaInicial" => "708"
                        "paginaFinal" => "719"
                        "link" => array:1 [
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                      "titulo" => "Comparison of reported outcomes with percutaneous versus surgical closure of ruptured sinus of Valsalva aneurysm"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            1 => "P&#46; Bhatla"
                            2 => "D&#46;B&#46; McElhinney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2014.11.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2015"
                        "volumen" => "115"
                        "paginaInicial" => "392"
                        "paginaFinal" => "398"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25488356"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluating operability in adults with congenital heart disease and the role of pretreatment with targeted pulmonary arterial hypertension therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            2 => "M&#46;A&#46; Gatzoulis"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijcard.2008.02.004"
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                        "tituloSerie" => "Int J Cardiol"
                        "fecha" => "2008"
                        "volumen" => "129"
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                        "paginaFinal" => "171"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ESC Guidelines for the management of grown-up congenital heart disease &#40;new version 2010&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46; Baumgartner"
                            1 => "P&#46; Bonhoeffer"
                            2 => "N&#46;M&#46; De Groot"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurheartj/ehq249"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2010"
                        "volumen" => "31"
                        "paginaInicial" => "2915"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical efficacy and safety of transcatheter closure of ruptured sinus of valsalva aneurysm"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46; Zhong"
                            1 => "S&#46;F&#46; Tong"
                            2 => "Q&#46; Zhang"
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                  ]
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                      "doi" => "10.1002/ccd.25323"
                      "Revista" => array:6 [
                        "tituloSerie" => "Catheter Cardiovasc Interv"
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                        "volumen" => "84"
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Revista Portuguesa de Cardiologia
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