que se leu este artigo
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array:1 [ 0 => array:2 [ "paginaInicial" => "167" "paginaFinal" => "175" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Administração de oleuropeína e folha de oliveira tem um efeito cardioprotetor em roedores: uma revisão sistemática" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3437 "Ancho" => 2925 "Tamanyo" => 336384 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Flow diagram of the systematic review.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rafaella Câmara Rocha Menezes, Kathleen Kruger Peres, Marina Tuerlinckx Costa-Valle, Larissa Slongo Faccioli, Eliane Dallegrave, Juliano Garavaglia, Simone Morelo Dal Bosco" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Rafaella Câmara Rocha" "apellidos" => "Menezes" ] 1 => array:2 [ "nombre" => "Kathleen Kruger" "apellidos" => "Peres" ] 2 => array:2 [ "nombre" => "Marina Tuerlinckx" "apellidos" => "Costa-Valle" ] 3 => array:2 [ "nombre" => "Larissa Slongo" "apellidos" => "Faccioli" ] 4 => array:2 [ "nombre" => "Eliane" "apellidos" => "Dallegrave" ] 5 => array:2 [ "nombre" => "Juliano" "apellidos" => "Garavaglia" ] 6 => array:2 [ "nombre" => "Simone Morelo" "apellidos" => "Dal Bosco" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121004443?idApp=UINPBA00004E" "url" => "/08702551/0000004100000002/v1_202202160601/S0870255121004443/v1_202202160601/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Ruptured sinus of Valsalva aneurysm: A reversible cause of suprasystemic pulmonary hypertension" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "177.e1" "paginaFinal" => "177.e4" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Lluis Asmarats, Armando Bethencourt, Antonio Rodríguez, Marta Noris, Jaume Maristany, Andrés Grau, Alfredo Gómez-Jaume, Vicente Peral" "autores" => array:8 [ 0 => array:4 [ "nombre" => "Lluis" "apellidos" => "Asmarats" "email" => array:1 [ 0 => "luis_asmarats@hotmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Armando" "apellidos" => "Bethencourt" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "Antonio" "apellidos" => "Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Marta" "apellidos" => "Noris" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Jaume" "apellidos" => "Maristany" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Andrés" "apellidos" => "Grau" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Alfredo" "apellidos" => "Gómez-Jaume" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 7 => array:3 [ "nombre" => "Vicente" "apellidos" => "Peral" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Cardiology, Hospital Universitari Son Espases, Palma, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Cardiology, Hospital Quirón Palmaplanas, Palma, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "<span class="elsevierStyleItalic">Shunt</span> cardíaco e hipertensão pulmonar: uma associação preocupante mas corrigível" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 954 "Ancho" => 2175 "Tamanyo" => 250168 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Fluoroscopic and echocardiographic images of the ruptured sinus of Valsalva aneurysm (arrow) during transient percutaneous occlusion testing (A) and after definitive closure (B) with the 12-mm Amplatzer Muscular VSD device, with trace peri-device leak and trivial left-to-right shunt through the VSD; (C) one-year echocardiographic follow-up showing appropriate apposition and sealing of the device and absence of pulmonary hypertension.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Sinus of Valsalva aneurysm (SVA) is a rare condition affecting 3% of Asian and <1% of Western patients undergoing cardiac surgery, with a 4:1 male predominance.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Etiology is either congenital or acquired secondary to infective endocarditis, syphilis, atherosclerosis, Marfan syndrome, autoimmune diseases or chest trauma. Aneurysms arising from the right sinus are the most common, usually rupturing into the right ventricle. Nearly 50% of SVAs coexist with a long-standing primary ventricular septal defect (VSD), most often supracristal. Rupture typically occurs in the mid-thirties, with variable severity of symptom onset according to size, location, associated lesions and acuity of the rupture. If left untreated, right ventricular overload and pulmonary arterial hypertension (PAH) develop, with a grim prognosis (one-year life expectancy).<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> While surgery remains the mainstay treatment for ruptured SVA, percutaneous treatment has emerged as a valid alternative for selected patients.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 39-year-old man presented with a two-month history of worsening dyspnea and rapidly progressive orthopnea, in New York Heart Association (NYHA) functional class III. Physical examination revealed a continuous systolic-diastolic murmur in the pulmonary area and raised jugular venous pressure, but no cyanosis. The electrocardiogram showed sinus tachycardia with right bundle branch block, and the chest X-ray revealed cardiomegaly with pulmonary venous congestion. Transthoracic echocardiography (TTE) revealed right-sided volume overload with right ventricular enlargement (45 mm), dilated pulmonary trunk (38 mm) with near-systemic PAH (>90 mmHg), and the presence of a perimembranous ventricular septal defect (VSD), with normal left ventricular size and function (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>A). Transesophageal echocardiography (TEE) confirmed the presence of a 3-mm perimembranous VSD with bidirectional shunting (predominantly right-to-left) (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>B), while also revealing a 7-mm right SVA ruptured into the right ventricular outflow tract adjacent to the pulmonary valve (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>C). Following multidisciplinary heart team discussion and considering the anatomical suitability of the rupture opening for a transcatheter approach (moderate sized defect, optimal proximal and distal margins, no associated aortic regurgitation), the patient was referred for transcatheter ruptured SVA closure, after prior balloon test occlusion to assess PAH reversibility.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The procedure was performed under fluoroscopic and TEE guidance, using a retrograde approach, under intravenous heparin (80 U/kg) and antibiotic cover (cefazolin). A Swan-Ganz thermodilution catheter was inserted through the right cephalic vein. Baseline invasively determined pressures showed suprasystemic PAH with a mean pulmonary pressure of 59 mmHg and a mean aortic pressure of 50 mmHg. A pigtail catheter for aortography was advanced from the left femoral artery. Through right femoral arterial access, the SVA defect was crossed retrogradely from the aorta into the right ventricular outflow tract with a Judkins right catheter (Cordis Corp., Miami, FL), which was exchanged for a Mullins sheath (Cook Inc., Bloomington, IN) through a stiff exchange wire. A 10/5-mm Amplatzer Vascular Plug III (Abbott Vascular, Santa Clara, CA) was first advanced through the Mullins sheath to occlude the ruptured SVA for 30 min with incomplete shunt sealing, and thereafter replaced by a 12-mm Amplatzer Muscular VSD device, resulting in successful shunt occlusion (<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>A). Rapid hemodynamic improvement was seen during the transient occlusion test, with a marked reduction in mean pulmonary pressure (from 59 to 49 mmHg), increase in mean aortic pressure (from 50 to 73 mmHg), and normalization of oxygen saturation (SpO<span class="elsevierStyleInf">2</span> at 4 l/min from 86% to 100%) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). After confirmation of the suitability for closure of the ruptured SVA, the 12-mm Amplatzer Muscular VSD device was released, with minimal residual peri-device leak, no aortic regurgitation and inversion of the VSD shunt (<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>B). The small VSD was considered hemodynamically insignificant (restrictive) and was therefore untreated. The patient was discharged with no complications on dual antiplatelet therapy for six months, and under sildenafil 20 mg/8 h and furosemide 20 mg/24 h. At one-year follow-up, the patient remained without events, in NYHA functional class I, with minimal resting left-to-right shunt, and complete regression of suprasystemic PAH, allowing discontinuation of furosemide and sildenafil (<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>C).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">The present case demonstrates the reversal of severe flow-mediated PAH related to systemic-to-pulmonary shunting with pulmonary overcirculation following transcatheter closure of a ruptured SVA into the right ventricle.</p><p id="par0025" class="elsevierStylePara elsevierViewall">SVA are generally silent until rupture into a cardiac chamber. In our patient with concomitant SVA and VSD, the right coronary cusp aneurysm probably occluded the VSD until the sinus ruptured into the right ventricle, resulting in a large systemic-to-pulmonary shunt through the ruptured SVA and causing systemic systolic pressure overload in the pulmonary artery and systemic diastolic pressure and volume overload in the right ventricle, with predominant right-to-left shunting through the VSD and desaturation. Interestingly, closure of the ruptured SVA led to resolution of the aortocardiac shunt, with inversion of the VSD shunt to left-to-right shunting and normalization of saturation.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The degree of reversibility of the pulmonary circulation can be assessed using short-acting pulmonary vasodilators, or through transient balloon test occlusion, particularly in patients with persistently elevated pulmonary vascular resistance despite a positive response to vasodilators, and those with bidirectional shunting.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> Although somewhat arbitrary, a drop in pulmonary pressures of ∼20% without a significant decrease in systemic pressure during test occlusion would suggest a high likelihood of benefiting from permanent closure. Closure of cardiac shunts is generally not recommended when pulmonary artery pressures are >2/3 of systemic values,<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> due to increased risk of sustained PAH, right heart failure and hypertensive crisis immediately after closure. However, the rationale for closure in our patient was the subacute onset of symptoms leading to rapid clinical deterioration and the presence of bidirectional shunting through the VSD, along with marked hemodynamic improvement after the transient occlusion test, making the hypothesis of fixed (irreversible) PAH highly unlikely, and thus highlighting a potential benefit from permanent shunt closure.</p><p id="par0035" class="elsevierStylePara elsevierViewall">In recent years, percutaneous closure of ruptured SVAs has emerged as a valid alternative to surgery. Although direct comparisons between the two approaches have been somewhat limited by selection bias (more severe aortic regurgitation and more complex associated lesions in patients undergoing surgery), transcatheter closure of ruptured SVAs has been shown to be safe and effective.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Suitability for percutaneous closure of intracardiac communications with associated PAH relies on anatomic features – magnitude of the shunt, presence of adequate rim to secure the device – and potential for PAH reversal. In our patient, three-dimensional TEE was crucial to precisely delineate two closely adjacent congenital defects, the shunt flows of which overlapped on TTE, showing anatomical suitability for percutaneous closure of the ruptured SVA. Although lacking solid scientific evidence, transcatheter closure of a ruptured SVA might be a reasonable option for patients with a rupture opening of less than 9 mm,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> in the absence of secondary complications (fistulous ruptured SVA or multiple rupture sites, significant aortic regurgitation) or pre-existing conditions requiring surgical correction (endocarditis, large VSD or other complex congenital defects).<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Of note, large lesions (>12 mm) should prompt preprocedural multimodality imaging assessment (including computed tomography or magnetic resonance imaging) to elucidate the best therapeutic approach.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Most importantly, while transcatheter occlusion of ruptured SVAs has emerged as a well-established alternative to surgical closure for highly selected patients, caution is warranted in the setting of associated severe PAH. Transient occlusion testing during cardiac catheterization is critical in determining the safety of permanent shunt closure, enabling differentiation between dynamic PAH and irreversible obstructive PAH, and providing reliable assessment of the reversibility of pulmonary vascular disease. To our knowledge, this is the first case report of suprasystemic flow-induced PAH regression following percutaneous closure of a ruptured SVA.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres1665658" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1479746" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1665659" "titulo" => "Resumo" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1479747" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflicts of interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-04-15" "fechaAceptado" => "2018-10-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1479746" "palabras" => array:3 [ 0 => "Sinus of Valsalva aneurysm" 1 => "Pulmonary hypertension" 2 => "Transcatheter closure" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec1479747" "palabras" => array:3 [ 0 => "Aneurisma do seio de Valsalva" 1 => "Hipertensão pulmonar" 2 => "Encerramento percutâneo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Management of patients with congenital heart defects and associated pulmonary arterial hypertension remains a major concern. With evolving targeted drug therapies and new iterations of transcatheter devices, treatment of appropriately selected patients with severe pulmonary hypertension, classically considered inoperable, has become feasible. We report the case of a patient with concomitant ruptured right sinus of Valsalva aneurysm and ventricular septal defect, with early reversal of suprasystemic pulmonary pressures following successful percutaneous closure of ruptured sinus of Valsalva.</p></span>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">O tratamento de pacientes com defeitos cardíacos congénitos e hipertensão pulmonar associada continua a ser um importante motivo de preocupação. Com o desenvolvimento de estratégias farmacológicas dirigidas e novos dispositivos transcatéter, o tratamento de pacientes selecionados com hipertensão pulmonar grave, tradicionalmente considerados inoperáveis, tornou-se viável. Apresentamos o caso de um paciente com aneurisma do seio de Valsalva direito roto e defeito do septo ventricular, com rápida reversão das pressões pulmonares suprassistêmicas após encerramento percutâneo do seio de Valsalva roto.</p></span>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 955 "Ancho" => 2167 "Tamanyo" => 314643 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(A) Transthoracic echocardiography showing a perimembranous ventricular septal defect (VSD, asterisk) with severe pulmonary hypertension; (B) two- and three-dimensional transesophageal echocardiography confirming VSD with bidirectional shunting, and unmasking a circular rupture opening of the right sinus of Valsalva aneurysm (6.5 mm×6.7<span class="elsevierStyleHsp" style=""></span>mm, arrow) into the right ventricular outflow tract (C).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 954 "Ancho" => 2175 "Tamanyo" => 250168 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Fluoroscopic and echocardiographic images of the ruptured sinus of Valsalva aneurysm (arrow) during transient percutaneous occlusion testing (A) and after definitive closure (B) with the 12-mm Amplatzer Muscular VSD device, with trace peri-device leak and trivial left-to-right shunt through the VSD; (C) one-year echocardiographic follow-up showing appropriate apposition and sealing of the device and absence of pulmonary hypertension.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SpO<span class="elsevierStyleInf">2</span>, % at 4 l/min \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PAP, mmHg \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">AoP, mmHg \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PCWP, mmHg \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">HR, bpm \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">CO, l/min \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Baseline \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">86 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">92/46/59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">61/40/50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">53/39/50<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">–<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 minutes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">79/40/49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">88/68/73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30/19/16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">68 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.47 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2835332.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Probable artefactual (damped pulmonary pressure).</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Not reliable by thermodilution technique in the context of a large systemic-to-pulmonary shunt.</p> <p class="elsevierStyleNotepara" id="npar0015">AoP: aortic pressure; CO: cardiac output; HR: heart rate; PAP: pulmonary arterial pressure; PCWP: pulmonary capillary wedge pressure; SpO<span class="elsevierStyleInf">2</span>: blood oxygen saturation.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Changes in hemodynamic parameters during transient occlusion test.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ruptured aneurysms of the sinus of Valsalva in oriental patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.H. Chu" 1 => "C.R. Hung" 2 => "S.S. How" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Thorac Cardiovasc Surg" "fecha" => "1990" "volumen" => "99" "paginaInicial" => "288" "paginaFinal" => "298" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2299866" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0040" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital aneurysms of sinus of Valsalva. A clinical study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Sakakibara" 1 => "S. Konno" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0002-8703(62)90018-2" "Revista" => array:7 [ "tituloSerie" => "Am Heart J" "fecha" => "1962" "volumen" => "63" "paginaInicial" => "708" "paginaFinal" => "719" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14496168" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1699258X13002064" "estado" => "S300" "issn" => "1699258X" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0045" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of reported outcomes with percutaneous versus surgical closure of ruptured sinus of Valsalva aneurysm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.M. Kuriakose" 1 => "P. Bhatla" 2 => "D.B. McElhinney" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjcard.2014.11.013" "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "2015" "volumen" => "115" "paginaInicial" => "392" "paginaFinal" => "398" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25488356" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0050" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluating operability in adults with congenital heart disease and the role of pretreatment with targeted pulmonary arterial hypertension therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Dimopoulos" 1 => "A. Peset" 2 => "M.A. Gatzoulis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijcard.2008.02.004" "Revista" => array:6 [ "tituloSerie" => "Int J Cardiol" "fecha" => "2008" "volumen" => "129" "paginaInicial" => "163" "paginaFinal" => "171" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18367267" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0055" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ESC Guidelines for the management of grown-up congenital heart disease (new version 2010)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H. Baumgartner" 1 => "P. Bonhoeffer" 2 => "N.M. De Groot" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehq249" "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2010" "volumen" => "31" "paginaInicial" => "2915" "paginaFinal" => "2957" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20801927" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0060" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical efficacy and safety of transcatheter closure of ruptured sinus of valsalva aneurysm" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Zhong" 1 => "S.F. Tong" 2 => "Q. 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