Pesquisa avançada
 array:25 [
  "pii" => "S0870255121002419"
  "issn" => "08702551"
  "doi" => "10.1016/j.repc.2020.11.011"
  "estado" => "S300"
  "fechaPublicacion" => "2021-10-01"
  "aid" => "1758"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2021"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Cardiol. 2021;40:715-24"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "en" => array:20 [
      "pii" => "S2174204921001550"
      "issn" => "21742049"
      "doi" => "10.1016/j.repce.2021.07.001"
      "estado" => "S300"
      "fechaPublicacion" => "2021-10-01"
      "aid" => "1758"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Rev Port Cardiol. 2021;40:715-24"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
        "titulo" => "Applicability of Martin-Hopkins formula and comparison with Friedewald formula for estimated low-density lipoprotein cholesterol in e&#95;COR study population"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "pt"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "715"
            "paginaFinal" => "724"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "Aplicabilidade da f&#243;rmula Martin-Hopkins e compara&#231;&#227;o com a f&#243;rmula Friedewald na estimativa do colesterol LDL na popula&#231;&#227;o do estudo e&#95;COR"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "pt" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:8 [
            "identificador" => "fig0010"
            "etiqueta" => "Figure 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:2 [
              0 => array:1 [
                "imagen" => "gr2a.jpeg"
              ]
              1 => array:1 [
                "imagen" => "gr2b.jpeg"
              ]
            ]
            "detalles" => array:1 [
              0 => array:3 [
                "identificador" => "at0010"
                "detalle" => "Figure "
                "rol" => "short"
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Scatter plots relating LDL-D&#44; LDL-F and LDL-M cholesterol with the coefficient of comparision between these variables in the study population and in the various groups&#46;</p> <p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">LDL-D direct low-density lipoprotein cholesterol&#59; LDL-F&#58; low-density lipoprotein cholesterol calculated according to the Friedewald formula&#59; LDL-M&#58; low-density lipoprotein cholesterol calculated according to the Martin-Hopkins formula&#59; &#961;&#58; Spearman&#8217;s rank correlation coefficient&#59; R<span class="elsevierStyleSup">2</span>&#58; linear regression&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "C&#225;tia Ferrinho, Ana Catarina Alves, Mafalda Bourbon, Sequeira Duarte"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "C&#225;tia"
                "apellidos" => "Ferrinho"
              ]
              1 => array:2 [
                "nombre" => "Ana Catarina"
                "apellidos" => "Alves"
              ]
              2 => array:2 [
                "nombre" => "Mafalda"
                "apellidos" => "Bourbon"
              ]
              3 => array:2 [
                "nombre" => "Sequeira"
                "apellidos" => "Duarte"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "pt" => array:9 [
          "pii" => "S0870255121002419"
          "doi" => "10.1016/j.repc.2020.11.011"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "pt"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121002419?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921001550?idApp=UINPBA00004E"
      "url" => "/21742049/0000004000000010/v1_202111300755/S2174204921001550/v1_202111300755/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S0870255121002729"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2021.07.001"
    "estado" => "S300"
    "fechaPublicacion" => "2021-10-01"
    "aid" => "1780"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "dis"
    "cita" => "Rev Port Cardiol. 2021;40:725-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
      "titulo" => "In search of accurate estimates of low-density lipoprotein cholesterol levels &#8211; a better compass"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "725"
          "paginaFinal" => "726"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Em busca de estimativas corretas dos n&#237;veis de colesterol LDL &#8211; uma b&#250;ssola melhor"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ant&#243;nio Miguel Ferreira"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Ant&#243;nio Miguel"
              "apellidos" => "Ferreira"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2174204921002877"
        "doi" => "10.1016/j.repce.2021.10.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921002877?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121002729?idApp=UINPBA00004E"
    "url" => "/08702551/0000004000000010/v1_202110050607/S0870255121002729/v1_202110050607/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S0870255121002602"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2021.06.011"
    "estado" => "S300"
    "fechaPublicacion" => "2021-10-01"
    "aid" => "1777"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "dis"
    "cita" => "Rev Port Cardiol. 2021;40:713-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
      "titulo" => "Arterial switch operation for transposition of great arteries&#58; Is coronary artery circulation evaluation necessary&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "713"
          "paginaFinal" => "714"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "<span class="elsevierStyleItalic">Switch</span> arterial&#58; a avalia&#231;&#227;o da circula&#231;&#227;o coron&#225;ria &#233; necess&#225;ria&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ant&#243;nio Marinho-da-Silva"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Ant&#243;nio"
              "apellidos" => "Marinho-da-Silva"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2174204921002865"
        "doi" => "10.1016/j.repce.2021.10.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921002865?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121002602?idApp=UINPBA00004E"
    "url" => "/08702551/0000004000000010/v1_202110050607/S0870255121002602/v1_202110050607/en/main.assets"
  ]
  "pt" => array:21 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Artigo original</span>"
    "titulo" => "Aplicabilidade da f&#243;rmula Martin&#8208;Hopkins e compara&#231;&#227;o com a f&#243;rmula Friedewald na estimativa do colesterol LDL na popula&#231;&#227;o do estudo e&#95;COR"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "715"
        "paginaFinal" => "724"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#225;tia Ferrinho, Ana Catarina Alves, Mafalda Bourbon, Sequeira Duarte"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "C&#225;tia"
            "apellidos" => "Ferrinho"
            "email" => array:1 [
              0 => "catia.ferrinho@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Ana Catarina"
            "apellidos" => "Alves"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Mafalda"
            "apellidos" => "Bourbon"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Sequeira"
            "apellidos" => "Duarte"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servi&#231;o de Endocrinologia&#44; Diabetes e Metabolismo do Hospital Egas Moniz&#44; Lisboa&#44; Portugal"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidade de Investiga&#231;&#227;o e Desenvolvimento&#44; Departamento de Promo&#231;&#227;o da Sa&#250;de e Preven&#231;&#227;o de Doen&#231;as N&#227;o Transmiss&#237;veis&#44; Instituto Nacional de Sa&#250;de Doutor Ricardo Jorge&#44; Lisboa&#44; Portugal"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Center for Biodiversity&#44; Functional &#38; Integrative Genomics&#44; Faculdade de Ci&#234;ncias&#44; Universidade de Lisboa&#44; Lisboa&#44; Portugal"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Autor para correspond&#234;ncia&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Applicability of Martin&#8208;Hopkins formula and comparison with Friedewald formula for estimated low&#8208;density lipoprotein cholesterol in e&#95;COR study population"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1159
            "Ancho" => 2091
            "Tamanyo" => 170447
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Diagramas de caixas para compara&#231;&#227;o das medianas e amplitude interquartil do colesterol direto e calculado na popula&#231;&#227;o do estudo e nos v&#225;rios grupos&#46; <span class="elsevierStyleBold">1</span> &#8208; Compara&#231;&#227;o na popula&#231;&#227;o do estudo &#40;n &#61; 1677&#47;n &#61; 1689&#41;&#46; <span class="elsevierStyleBold">2</span> &#8208; Compara&#231;&#227;o no grupo sob terap&#234;utica antidislipid&#233;mica &#40;n &#61; 470&#47;n &#61; 474&#41;&#46; <span class="elsevierStyleBold">3</span> &#8208; Compara&#231;&#227;o no grupo sem terap&#234;utica antidislipid&#233;mica &#40;n &#61; 1&#46;207&#47;n &#61; 1&#46;215&#41;&#46; <span class="elsevierStyleBold">4</span> &#8208; Compara&#231;&#227;o no grupo com diabetes <span class="elsevierStyleItalic">mellitus</span> &#40;n &#61; 192&#47;n &#61; 198&#41;&#46; <span class="elsevierStyleBold">5</span> &#8208; Compara&#231;&#227;o no grupo com obesidade &#40;n &#61; 373&#47;n &#61; 382&#41;&#46; <span class="elsevierStyleBold">6</span> &#8208; Compara&#231;&#227;o no grupo com hipertriglicerid&#233;mia &#40;TGs &#8805; 150 e &#60; 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; &#40;n &#61; 276&#41;&#46; <span class="elsevierStyleBold">7</span> &#8211; Compara&#231;&#227;o no grupo com cLDL&#8208;D &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;n &#61; 82&#47;84&#41;&#46; cLD&#8208;D&#44; colesterol LDL direto&#46; cLDL&#8208;F&#44; colesterol LDL calculado pela f&#243;rmula de Friedewald&#46; cLDL&#8208;M&#44; colesterol LDL calculado pela f&#243;rmula de Martin&#8208;Hopkins&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introdu&#231;&#227;o</span><p id="par0010" class="elsevierStylePara elsevierViewall">A doen&#231;a cardiovascular ateroscler&#243;tica &#233; uma das principais causas de morbilidade e mortalidade em Portugal&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">O colesterol presente na lipoprote&#237;na de baixa densidade &#40;cLDL&#41; est&#225; associado &#224; forma&#231;&#227;o de placas ateroscler&#243;ticas e &#233; um importante fator de risco modific&#225;vel para doen&#231;a cardiovascular&#44; sendo utilizado como alvo terap&#234;utico prim&#225;rio em recomenda&#231;&#245;es nacionais e internacionais&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">2&#8211;4</span></a> O estudo Disgen&#8208;Lipid&#44; observacional de 24 centros de Portugal&#44; mostrou que o atingimento dos valores&#8208;alvo do cLDL foi sub&#243;timo e que &#233; necess&#225;ria uma abordagem mais vigorosa deste fator de risco&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">5</span></a> De acordo com as recomenda&#231;&#245;es da Sociedade Europeia de Cardiologia &#40;ESC&#41; e da Sociedade Europeia de Aterosclerose &#40;EAS&#41;&#44; os objetivos do cLDL para as diferentes categorias de risco s&#227;o redu&#231;&#227;o &#8805; 50&#37; do valor basal e um valor alvo de &#60; 55<span class="elsevierStyleHsp" style=""></span>mg&#47;dL se risco muito alto &#40;grau I&#44; n&#237;vel de evid&#234;ncia C&#41;&#44; redu&#231;&#227;o &#8805; 50&#37; do valor basal e um valor alvo de &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL se risco alto &#40;grau I&#44; n&#237;vel de evid&#234;ncia A&#41;&#44; &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL se risco moderado &#40;grau IIa&#44; n&#237;vel de evid&#234;ncia A&#41; e &#60; 116<span class="elsevierStyleHsp" style=""></span>mg&#47;dL se risco baixo &#40;grau IIb&#44; n&#237;vel de evid&#234;ncia A&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">O m&#233;todo de refer&#234;ncia para a determina&#231;&#227;o do cLDL &#233; a ultracentrifuga&#231;&#227;o e precipita&#231;&#227;o qu&#237;mica &#40;quantifica&#231;&#227;o &#946;&#41;&#44; um processo moroso&#44; dispendioso e pouco vi&#225;vel na pr&#225;tica cl&#237;nica&#46; Apesar da exist&#234;ncia de v&#225;rios m&#233;todos para a determina&#231;&#227;o direta da concentra&#231;&#227;o de LDL&#44; muitos laborat&#243;rios cl&#237;nicos utilizam a estimativa do cLDL pela simplicidade e aus&#234;ncia de custos&#44; sendo a f&#243;rmula de Friedewald a mais amplamente usada&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">3</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">A equa&#231;&#227;o de Friedewald baseia&#8208;se na subtra&#231;&#227;o do colesterol n&#227;o HDL pela varia&#231;&#227;o de VLDL numa rela&#231;&#227;o de 1&#58;5 de acordo com os triglic&#233;ridos &#40;Tgs&#41; e &#233; utilizada na pr&#225;tica cl&#237;nica desde 1972&#46; Esta propor&#231;&#227;o fixa pode levar a incorre&#231;&#245;es na estimativa de cLDL que poder&#227;o ter impacto na cl&#237;nica e em decis&#245;es terap&#234;uticas&#46; Foi salientado pelo pr&#243;prio autor que a simples divis&#227;o dos triglic&#233;ridos por cinco n&#227;o permite uma estimativa precisa da concentra&#231;&#227;o de VLDL e em v&#225;rias circunst&#226;ncias&#44; como Tgs acima de 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL e disbetalipoproteinemias&#44; esta f&#243;rmula n&#227;o pode ser aplicada&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">4&#44;6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">V&#225;rios estudos t&#234;m descrito a tend&#234;ncia da f&#243;rmula de Friedewald de subestimar os resultados do cLDL sobretudo naqueles com hipertrigliceridemia &#40;Tgs &#8805; 150<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; diabetes <span class="elsevierStyleItalic">mellitus</span>&#44; doen&#231;a hep&#225;tica alco&#243;lica e doen&#231;a renal cr&#243;nica em di&#225;lise&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">7&#8211;11</span></a> A subestima&#231;&#227;o pode ser problem&#225;tica&#44; podendo levar &#224; protela&#231;&#227;o de cuidados preventivos e terap&#234;uticos&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">7&#44;11</span></a> Por esta raz&#227;o&#44; v&#225;rios investigadores t&#234;m tentado modificar o r&#225;cio dos Tgs&#58;VLDL de forma a tornar a f&#243;rmula mais precisa e exata&#46; Em 2013&#44; Martin et al<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">12</span></a> sugeriram uma f&#243;rmula semelhante &#224; de Friedewald&#44; em que a estimativa do colesterol VLDL &#233; calculada pela divis&#227;o dos Tgs por um fator ajust&#225;vel que depende do valor do colesterol n&#227;o HDL e dos Tgs &#40;<a class="elsevierStyleCrossRef" href="#sec0075">Anexo 1</a>&#41;&#46; Estudos de valida&#231;&#227;o t&#234;m mostrado a sua superioridade &#224; f&#243;rmula original de Friedewald na estimativa da concentra&#231;&#227;o do cLDL em v&#225;rias popula&#231;&#245;es&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">11&#44;13&#8211;15</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Assim&#44; os objetivos do nosso trabalho foram mostrar a aplicabilidade da nova f&#243;rmula&#44; que nome&#225;mos f&#243;rmula de Martin&#8208;Hopkins&#44; numa amostra da popula&#231;&#227;o portuguesa&#44; comparar com a f&#243;rmula de Friedewald e determinar qual se aproxima mais do cLDL determinado por m&#233;todo laboratorial direto&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Material e m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Popula&#231;&#227;o do estudo</span><p id="par0045" class="elsevierStylePara elsevierViewall">Foram inclu&#237;dos 1689 participantes do estudo e&#95;COR&#44; que decorreu entre 2012 e 2014&#46; O estudo e&#95;COR foi populacional com componente laboratorial numa amostra aleat&#243;ria e estratificada por g&#233;nero e idade&#44; das cinco regi&#245;es de Portugal continental&#44; com o objetivo de obter dados representativos dos principais fatores de risco cardiovascular na popula&#231;&#227;o portuguesa&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">16</span></a> O estudo e&#95;COR foi aprovado pela Comiss&#227;o de &#201;tica do Instituto Nacional de Sa&#250;de Doutor Ricardo Jorge e pela Comiss&#227;o Nacional de Prote&#231;&#227;o de Dados&#46; Todos os procedimentos foram realizados de acordo com as boas pr&#225;ticas da Declara&#231;&#227;o de Hels&#237;nquia&#44; com a explica&#231;&#227;o e o preenchimento de consentimento informado&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Avalia&#231;&#245;es cl&#237;nicas</span><p id="par0050" class="elsevierStylePara elsevierViewall">Todos os participantes completaram um question&#225;rio que inclu&#237;a dados demogr&#225;ficos&#44; hist&#243;ria pessoal e familiar&#44; medica&#231;&#227;o habitual e h&#225;bitos comportamentais&#46; Foi avaliada a press&#227;o arterial &#40;em mmHg&#41;&#44; o peso &#40;em kg&#41;&#44; a altura &#40;em cm&#41; e o per&#237;metro da cintura &#40;em cm&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Avalia&#231;&#245;es laboratoriais</span><p id="par0055" class="elsevierStylePara elsevierViewall">As an&#225;lises de sangue foram obtidas ap&#243;s jejum de 12 horas e foram determinados v&#225;rios par&#226;metros bioqu&#237;micos&#46; A concentra&#231;&#227;o do cLDL foi determinada pelo m&#233;todo colorim&#233;trico direto no equipamento Cobas Integra&#174; 400<span class="elsevierStyleHsp" style=""></span>da Roche&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Aplicamos as f&#243;rmulas de Martin&#8208;Hopkins e Friedewald para a estimativa de cLDL &#40;<a class="elsevierStyleCrossRef" href="#sec0075">Anexo 1</a>&#41;&#46; A f&#243;rmula de Friedewald n&#227;o foi aplicada em 12 casos por triglic&#233;ridos &#8805; 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">An&#225;lise estat&#237;stica</span><p id="par0065" class="elsevierStylePara elsevierViewall">Os resultados s&#227;o apresentados em mediana e amplitude interquartil &#40;mediana &#91;IQR&#93;&#41;&#46; Dividimos a popula&#231;&#227;o do estudo em seis grupos para melhor caracteriza&#231;&#227;o das correla&#231;&#245;es e medianas segundo diferentes condi&#231;&#245;es &#40;<a class="elsevierStyleCrossRef" href="#sec0075">Anexo 2</a>&#41;&#46; Para a correla&#231;&#227;o entre o colesterol LDL direto &#40;cLDL&#8208;D&#41;&#44; colesterol LDL estimado pela f&#243;rmula de Friedewald &#40;cLDL&#8208;F&#41; e colesterol LDL estimado pela f&#243;rmula de Martin&#8208;Hopkins &#40;cLDL&#8208;M&#41; utilizou&#8208;se o coeficiente de correla&#231;&#227;o &#961; de Spearman e a regress&#227;o linear &#40;R<span class="elsevierStyleSup">2</span>&#41;&#46; Para avaliar as diferen&#231;as das medianas do cLDL&#8208;F e cLDL&#8208;M com o cLDL&#8208;D recorreu&#8208;se ao teste de Wilcoxon&#46; Na an&#225;lise da concord&#226;ncia do cLDL&#8208;F e cLDL&#8208;M com o cLDL&#8208;D de acordo com alvos terap&#234;uticos das linhas de orienta&#231;&#227;o da ESC&#47;EAS 2019<span class="elsevierStyleSup">3</span>&#44; empregou&#8208;se a estat&#237;stica <span class="elsevierStyleItalic">kappa</span> de Cohen &#40;&#954;&#41;&#46; O n&#237;vel de signific&#226;ncia aceite foi p &#60; 0&#44;05&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Resultados</span><p id="par0070" class="elsevierStylePara elsevierViewall">A idade mediana da popula&#231;&#227;o do estudo &#40;1689 participantes&#41; foi de 51 &#40;34&#41; anos e 50&#44;2&#37; da popula&#231;&#227;o eram do sexo masculino&#46; O IMC foi de 27&#44;0 &#40;5&#44;7&#41; kg&#47;m<span class="elsevierStyleSup">2</span> no sexo masculino e 25&#44;8 &#40;6&#44;7&#41; kg&#47;m<span class="elsevierStyleSup">2</span> no sexo feminino &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Tabela 1</a>&#41;&#46; Foi tamb&#233;m calculada para todos os participantes a massa de gordura relativa &#40;<span class="elsevierStyleItalic">Relative Fat Mass</span> &#8211; RFM&#41;&#46; A hipertens&#227;o arterial &#40;HTA&#41;&#44; a obesidade e diabetes <span class="elsevierStyleItalic">mellitus</span> &#40;DM&#41; estavam presentes em 48&#44;5&#37;&#44; 22&#44;6&#37; e 11&#44;7&#37; da popula&#231;&#227;o do estudo&#46; Estavam sob terap&#234;utica antidislipid&#233;mica 28&#44;1&#37; &#40;n &#61; 474&#41; dos participantes&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">O colesterol total e o colesterol HDL tiveram como mediana 192 &#40;48&#41; e 54 &#40;20&#41; mg&#47;dL&#44; respetivamente &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Tabela 2</a>&#41;&#46; A mediana do colesterol LDL direto &#40;cLDL&#8208;D&#41; foi 117&#44;0 &#40;44&#44;0&#41; mg&#47;dL&#59; a mediana do colesterol estimado cLDL&#8208;F foi 113&#44;8 &#40;43&#44;2&#41; mg&#47;dL com uma diferen&#231;a estatisticamente significativa de &#8208;3&#44;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;IC 95&#37;&#58; &#8208;3&#44;3 a &#8208;2&#44;8&#44; p &#60; 0&#44;001&#41; em rela&#231;&#227;o ao cLDL&#8208;D&#59; a mediana do colesterol estimado cLDL&#8208;M foi 114&#44;6 &#40;43&#44;7&#41; mg&#47;dL com uma diferen&#231;a estatisticamente significativa de &#8208;2&#44;8<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;IC 95&#37;&#58; &#8208;3&#44;1 a &#8208;2&#44;6&#44; p &#60; 0&#44;001&#41; em rela&#231;&#227;o ao cLDL&#8208;D&#46; Em rela&#231;&#227;o ao fator usado para o c&#225;lculo do cLDL&#8208;M a mediana foi de 4&#44;8 &#40;1&#44;1&#41;&#46; A mediana do colesterol n&#227;o HDL e dos triglic&#233;ridos foi 135 &#40;50&#41; mg&#47;dL e 94 &#40;60&#41; mg&#47;dL&#44; respetivamente&#46; Na amostra&#44; 12 participantes &#40;0&#44;7&#37;&#41; apresentaram triglic&#233;ridos &#8805; 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">A distribui&#231;&#227;o dos valores do cLDL direto e calculado para a popula&#231;&#227;o do estudo e para os diferentes grupos &#40;sob terap&#234;utica antidislipid&#233;mica&#44; sem terap&#234;utica antidislipid&#233;mica&#44; diabetes <span class="elsevierStyleItalic">mellitus</span>&#44; obesidade&#44; hipertrigliceridemia e cLDL&#8208;D &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; est&#225; representada na <a class="elsevierStyleCrossRef" href="#fig0005">Figura 1</a>&#46; Para os v&#225;rios grupos foram calculadas a mediana e a diferen&#231;a entre medianas do colesterol direto e calculado &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Tabela 3</a>&#41;&#46; Para todos os grupos foi poss&#237;vel verificar valores calculados pela f&#243;rmula de Friedewald mais baixos e diferen&#231;as maiores entre as medianas do cLDL&#8208;F e cLDL&#8208;D&#46; No grupo com cLDL&#8208;D &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL foi encontrada uma diferen&#231;a n&#227;o significativa de &#8208;0&#44;95 &#40;IC 95&#37;&#58; &#8208;2&#44;1 a 0&#44;2&#44; p &#61; 0&#44;117&#41; entre os valores calculados pela f&#243;rmula de Martin&#8208;Hopkins e o colesterol LDL direto&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Quando avaliamos a correla&#231;&#227;o entre as vari&#225;veis cLDL&#8208;F&#47;cLDL&#8208;D e cLDL&#8208;M&#47;cLDL&#8208;D na popula&#231;&#227;o do estudo e nos diferentes grupos verificou&#8208;se que em todos os casos as correla&#231;&#245;es s&#227;o estatisticamente significativas &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figura 2</a>&#41; e com valores superiores na correla&#231;&#227;o cLDL&#8208;M&#47;cLDL&#8208;D&#46; Estes valores foram muito pr&#243;ximos de 1 na popula&#231;&#227;o do estudo e em cinco grupos avaliados&#58; sob terap&#234;utica antidislipid&#233;mica&#44; sem terap&#234;utica antidislipid&#233;mica&#44; diabetes <span class="elsevierStyleItalic">mellitus</span>&#44; obesidade e hipertrigliceridemia &#40;valores de &#961; de Spearman para cLDL&#8208;F&#47;cLDL&#8208;D entre 0&#44;978 e 0&#44;983 e R<span class="elsevierStyleSup">2</span> entre 0&#44;966 e 0&#44;971&#59; para cLDL&#8208;M&#47;cLDL&#8208;D os valores de &#961; foram entre 0&#44;983 e 0&#44;988 e R<span class="elsevierStyleSup">2</span> entre 0&#44;976 e 0&#44;982&#41;&#46; No grupo com colesterol cLDL&#8208;D &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; a correla&#231;&#227;o &#961; e R<span class="elsevierStyleSup">2</span> foi inferior&#44; embora mostrando superioridade para a f&#243;rmula de Martin&#8208;Hopkins &#40;&#961; &#40;cLDL&#8208;F&#47;cLDL&#8208;D&#41; &#61; 0&#44;739&#44; R<span class="elsevierStyleSup">2</span> &#40;cLDL&#8208;F&#47;cLDL&#8208;D&#41; &#61; 0&#44;683&#59; &#961; &#40;cLDL&#8208;M&#47;cLDL&#8208;D&#41; &#61; 0&#44;769&#44; R<span class="elsevierStyleSup">2</span> &#40;cLDL&#8208;M&#47;cLDL&#8208;D&#41; &#61; 0&#44;758&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">A concord&#226;ncia do colesterol LDL calculado e direto foi realizada tendo em conta os alvos terap&#234;uticos de acordo com as linhas de orienta&#231;&#227;o da ESC&#47;EAS 2019 &#40;LDL &#60; 55&#44; &#60; 70&#44; &#60; 100&#44; &#60; 116<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">3</span></a>&#46; O n&#250;mero de casos estimados corretamente com valores abaixo destes alvos foi semelhante entre ambas as f&#243;rmulas &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Tabela 4</a>&#41;&#46; A maior diferen&#231;a percentual entre a concord&#226;ncia dos casos foi a favor da f&#243;rmula de Martin&#8208;Hopkins quando valores de cLDL&#8208;D &#60; 55<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;a f&#243;rmula de Friedewald classificou corretamente 75&#44;0&#37; &#91;IC 95&#37; 50&#44;5&#8208;89&#44;8 <span class="elsevierStyleItalic">versus</span> a f&#243;rmula de Martin&#8208;Hopkins&#44; que classificou corretamente 87&#44;5&#37; &#91;IC 95&#37; 63&#44;9&#8208;96&#44;5&#93; dos participantes neste alvo&#41;&#46; Nos outros alvos terap&#234;uticos verificou&#8208;se concord&#226;ncia superior a 90&#37; para as duas f&#243;rmulas&#46; O valor de <span class="elsevierStyleItalic">kappa</span> mostrou concord&#226;ncia &#171;excelente&#187; &#40;ou seja&#44; intervalo entre 0&#44;81 a 1&#41; nos n&#237;veis &#60; 70&#44; &#60; 100 e &#60; 116<span class="elsevierStyleHsp" style=""></span>mg&#47;dL para ambas as f&#243;rmulas&#46; Na categoria &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL foi obtido o maior valor de &#954; &#61; 0&#44;90 para a concord&#226;ncia entre o cLDL&#8208;M e o cLDL&#8208;D&#46; Em todos os casos a concord&#226;ncia teve signific&#226;ncia estat&#237;stica &#40;p &#60; 0&#44;001&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Quando avali&#225;mos a discord&#226;ncia entre o colesterol calculado e direto para os alvos terap&#234;uticos de risco muito alto e alto&#44; o cLDL&#8208;F categorizou 60&#44;0&#37; &#40;n &#61; 18&#41; dos casos de cLDL&#8208;D &#62; 55<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;n &#61; 30&#41; como dentro do alvo LDL &#60; 55<span class="elsevierStyleHsp" style=""></span>mg&#47;dL e 29&#44;0&#37; &#40;n &#61; 31&#41; dos casos de cLDL&#8208;D &#62; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;n &#61; 107&#41; como dentro do alvo LDL &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46; Para o cLDL&#8208;M&#44; a percentagem de discord&#226;ncia foi 36&#44;4&#37; &#40;n &#61; 8&#47;n &#61; 22&#41; e 25&#44;2&#37; &#40;n &#61; 26&#47;n &#61;103&#41;&#44; respetivamente&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Para os 12 casos nos quais n&#227;o foi aplicada a f&#243;rmula de Friedewald &#40;triglic&#233;ridos &#8805; 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; verificou&#8208;se&#44; como mostrado na <a class="elsevierStyleCrossRef" href="#fig0020">Figura 3</a>&#44; que a correla&#231;&#227;o entre o cLDL&#8208;M e o cLDL&#8208;D foi forte e com signific&#226;ncia estat&#237;stica &#40;&#961; &#61; 0&#44;916 e R<span class="elsevierStyleSup">2</span> &#61; 0&#44;955&#44; p &#60; 0&#44;001&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discuss&#227;o</span><p id="par0105" class="elsevierStylePara elsevierViewall">O colesterol LDL &#233; um alvo terap&#234;utico prim&#225;rio na preven&#231;&#227;o das doen&#231;as cardiovasculares &#40;DCV&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">2&#8211;4</span></a> Para esse fim &#233; necess&#225;ria acur&#225;cia na sua determina&#231;&#227;o&#46; O m&#233;todo de refer&#234;ncia para o doseamento do cLDL &#233; dispendioso e invi&#225;vel na pr&#225;tica cl&#237;nica&#46; Assim&#44; pela sua simplicidade &#233; utilizada h&#225; cerca de tr&#234;s d&#233;cadas a estimativa da concentra&#231;&#227;o de cLDL pela f&#243;rmula de Friedewald&#44; que tem sido refutada devido &#224; sua menor acur&#225;cia em situa&#231;&#245;es cl&#237;nicas como a hipertrigliceridemia e a diabetes <span class="elsevierStyleItalic">mellitus</span>&#46; O objetivo do presente trabalho foi aplicar uma nova f&#243;rmula que utiliza um r&#225;cio Tgs&#58;VLDL vari&#225;vel &#40;<a class="elsevierStyleCrossRef" href="#sec0075">Anexo 1</a>&#41; numa amostra da popula&#231;&#227;o portuguesa de um estudo nacional&#44; o estudo e&#95;COR&#44; da responsabilidade do Instituto Ricardo Jorge&#44; que decorreu entre 2012 e 2014&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">16</span></a> Esta nova f&#243;rmula &#40;classificada como f&#243;rmula de Martin&#8208;Hopkins&#41; tem mostrado acur&#225;cia superior &#224; de Friedewald em v&#225;rias popula&#231;&#245;es<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">11&#8211;13</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">No presente estudo&#44; a amostra em termos descritivos apresenta uma preval&#234;ncia dos sexos semelhante &#40;50&#44;2&#37; masculino e 49&#44;8&#37; feminino&#41;&#44; com idades entre 18 e 79&#44; com uma mediana de 51 &#40;34&#41; anos&#46; A mediana do IMC correspondeu a &#8220;excesso de peso&#8221; nos dois sexos &#40;IMC de 27&#44;0 &#91;5&#44;7&#93; kg&#47;m<span class="elsevierStyleSup">2</span> no sexo masculino e 25&#44;8 &#91;6&#44;7&#93; kg&#47;m<span class="elsevierStyleSup">2</span> no feminino&#41; e a mediana da massa de gordura relativa &#40;<span class="elsevierStyleItalic">Relative Fat Mass</span> &#8211; RFM<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">15</span></a>&#41; correspondeu a &#8220;obesidade&#8221; &#40;RFM de 28&#44;6 &#91;6&#44;6&#93;&#37; no sexo masculino e 40&#44;8 &#91;8&#44;2&#93;&#37; no sexo feminino&#41;&#46; O RFM &#233; um par&#226;metro que utiliza o per&#237;metro da cintura em vez do peso para definir obesidade&#44; sendo comprovada em v&#225;rios estudos a sua utilidade relativamente ao IMC&#44; com pontos de corte a serem definidos e validados consoante o tipo de popula&#231;&#227;o&#47;etnia&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">17&#44;18</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Em rela&#231;&#227;o aos fatores de risco para DCV&#44; verificou&#8208;se que quase metade dos participantes apresentava HTA &#40;48&#44;5&#37;&#41;&#46; A obesidade estava presente em 22&#44;6&#37; e a diabetes <span class="elsevierStyleItalic">mellitus</span> em 11&#44;7&#37; da amostra&#44; aproximando&#8208;se da preval&#234;ncia de DM em 2012 de 12&#44;9&#37; na popula&#231;&#227;o portuguesa&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">19</span></a> No entanto&#44; a preval&#234;ncia de DM na nossa amostra n&#227;o foi ajustada &#224; popula&#231;&#227;o portuguesa&#44; que&#44; de acordo com o relat&#243;rio do estudo e&#95;COR&#44; foi de 8&#44;9&#37; &#40;IC 95&#37;&#58; 7&#44;5&#8208;10&#44;3&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">16</span></a> Mais de um quarto da nossa amostra estava sob estatinas &#40;26&#44;9&#37;&#41;&#44; o que mostra a ampla utiliza&#231;&#227;o destes f&#225;rmacos em Portugal&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">20</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">A mediana dos valores doseados diretamente &#40;cLDL&#8208;D&#41; foi superior &#224; mediana dos valores estimados &#40;cLDL&#8208;F e cLDL&#8208;M&#41; na popula&#231;&#227;o do estudo&#44; com diferen&#231;a entre medianas estatisticamente significativa para os valores calculados pela f&#243;rmula de Friedewald de &#8208;3&#44;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;IC 95&#37;&#58; &#8208;3&#44;3 a &#8208;2&#44;8&#44; p &#60; 0&#44;001&#41; e para aqueles calculados pela f&#243;rmula de Martin&#8208;Hopkins de &#8208;2&#44;8<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;IC 95&#37;&#58; &#8208;3&#44;1 a &#8208;2&#44;6&#44; p &#60; 0&#44;001&#41;&#46; Apesar de um coeficiente de correla&#231;&#227;o forte&#44; houve dissemelhan&#231;as diferentes de zero em rela&#231;&#227;o &#224; determina&#231;&#227;o direta do cLDL para ambas as f&#243;rmulas&#46; As diferen&#231;as encontradas na popula&#231;&#227;o do estudo foram inferiores ao relatado noutros estudos e em outras popula&#231;&#245;es&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">11&#44;15</span></a> A mediana do r&#225;cio Tgs&#58;VLDL para o c&#225;lculo do cLDL&#8208;M foi de 4&#44;8 &#40;1&#44;1&#41;&#44; aproximando&#8208;se ao encontrado por Sathiyakumar et al&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">21</span></a> de 4&#44;9 &#40;4&#44;3&#8208;5&#44;7&#41;&#46; Este estudo avaliou o desempenho da f&#243;rmula de Martin&#8208;Hopkins <span class="elsevierStyleItalic">versus</span> a f&#243;rmula de Friedewald no estado de jejum e p&#243;s&#8208;prandial&#44; mostrando superioridade da f&#243;rmula de Martin&#8208;Hopkins nos dois estados&#46; Em compara&#231;&#227;o com o estudo de Martin et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">12</span></a> o nosso r&#225;cio foi inferior ao relatado de 5&#44;2 &#40;4&#44;5&#8208;6&#44;0&#41;&#44; sendo um fator dependente da composi&#231;&#227;o da popula&#231;&#227;o em an&#225;lise&#46; No entanto&#44; os r&#225;cios descritos s&#227;o pr&#243;ximos de 5&#44; o que explica a semelhan&#231;a no desempenho entre f&#243;rmulas no presente e nos estudos anteriormente referidos&#44; com superioridade em todos os casos para a f&#243;rmula de Martin&#8208;Hopkins&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">De acordo com estudos anteriores&#44; a tend&#234;ncia de subestimar os valores de cLDL pela f&#243;rmula de Friedewald ocorre sobretudo na presen&#231;a de DM&#44; hipertrigliceridemia e cLDL &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">7&#44;9&#44;22&#44;23</span></a> No nosso estudo verific&#225;mos a tend&#234;ncia para ambas as f&#243;rmulas de subestimar os valores de cLDL na popula&#231;&#227;o do estudo e nos grupos definidos &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figura 1</a> e <a class="elsevierStyleCrossRef" href="#tbl0015">Tabela 3</a>&#41;&#46; A mediana de cLDL&#8208;D mais elevada foi no grupo com hipertrigliceridemia &#40;cLDL&#8208;D de 131&#44;0 &#91;46&#44;0&#93; mg&#47;dL&#41;&#44; sendo neste grupo encontrada a diferen&#231;a mais significativa entre as medianas de cLDL&#8208;F e o cLDL&#8208;D de &#8208;9&#44;0<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;IC 95&#37;&#58; &#8208;10&#44;0 a &#8208;8&#44;5&#44; p &#60; 0&#44;001&#41;&#46; No grupo com DM a diferen&#231;a entre os valores de cLDL&#8208;F e o cLDL&#8208;D tamb&#233;m foi expressiva de &#8208;5&#44;0 &#40;IC 95&#37;&#58; &#8208;6&#44;0 a &#8208;4&#44;0&#44; p &#60; 0&#44;001&#41;&#46; Notavelmente&#44; os valores de cLDL&#8208;M estiveram mais pr&#243;ximos do cLDL&#8208;D nestes dois grupos&#58; &#8208;2&#44;2 &#40;IC 95&#37;&#58; &#8208;3&#44;0 a &#8208;1&#44;5&#44; p &#60; 0&#44;001&#41; para o grupo com hipertrigliceridemia e &#8208;2&#44;0 &#40;IC 95&#37;&#58; &#8208;2&#44;8 a &#8208;1&#44;3&#44; p &#60; 0&#44;001&#41; para o grupo com DM&#46; Estes resultados mostram a tend&#234;ncia da f&#243;rmula de Friedewald de subestimar os valores de cLDL quando estas condi&#231;&#245;es est&#227;o presentes e ser&#225; nestas condi&#231;&#245;es cl&#237;nicas que a f&#243;rmula de Martin&#8208;Hopkins poder&#225; ter mais utilidade&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">9&#44;24&#44;25</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Quando avali&#225;mos os coeficientes da correla&#231;&#227;o &#961; de Spearman e a regress&#227;o linear por grupos verific&#225;mos que em todos os casos estes foram superiores para os valores calculados pela f&#243;rmula de Martin&#8208;Hopkins em compara&#231;&#227;o com a f&#243;rmula de Friedewald&#44; variando os valores de cLDL&#8208;M de forma quase perfeita com os valores de cLDL&#8208;D nos grupos sob terap&#234;utica antidislipid&#233;mica&#44; sem terap&#234;utica antidislipid&#233;mica&#44; obesidade&#44; diabetes <span class="elsevierStyleItalic">mellitus</span> e hipertrigliceridemia&#44; mostrando uma correla&#231;&#227;o forte com os valores de cLDL&#8208;D &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figura 2</a>&#41;&#46; Para os valores de cLDL&#8208;F os coeficientes de correla&#231;&#227;o e regress&#227;o linear mostraram tamb&#233;m uma forte aproxima&#231;&#227;o com a varia&#231;&#227;o dos valores determinados de cLDL&#8208;D&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Para o cLDL&#8208;D &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; alvo terap&#234;utico de grau I e n&#237;vel de evid&#234;ncia A para indiv&#237;duos de alto risco de DCV&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">3</span></a> descrito noutros estudos como ponto de menor acur&#225;cia da f&#243;rmula de Friedewald&#44; <a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">8&#44;11&#44;13&#44;15&#44;22&#44;23</span></a> foi poss&#237;vel verificar uma correla&#231;&#227;o mais fraca em compara&#231;&#227;o com outros grupos para ambas as f&#243;rmulas&#44; com superioridade para a f&#243;rmula de Martin&#8208;Hopkins &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figura 2</a>&#41;&#46; A mediana de valores do cLDL&#8208;M neste grupo foi muito pr&#243;xima da mediana do cLDL&#8208;D&#44; com uma diferen&#231;a n&#227;o significativa de &#8208;0&#44;95 &#40;IC 95&#37;&#58; &#8208;2&#44;1 a 0&#44;2&#44; p &#61; 0&#44;117&#41;&#44; mostrando a superioridade da f&#243;rmula de Martin&#8208;Hopkins neste intervalo de valores&#44; o que tamb&#233;m foi validado em outros estudos&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">11&#44;13&#44;21&#44;24</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">Em rela&#231;&#227;o &#224; concord&#226;ncia do cLDL&#8208;M e do cLDL&#8208;F com o cLDL&#8208;D nos alvos terap&#234;uticos recomendados pela ESC&#47;EAS 2019&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">3</span></a> a exatid&#227;o foi menor &#224; medida que o valor de cLDL&#8208;D diminuiu para ambas as f&#243;rmulas&#46; No entanto&#44; verificou&#8208;se superioridade para a f&#243;rmula de Martin&#8208;Hopkins nos tr&#234;s primeiros alvos &#40;cLDL&#8208;D &#60; 55&#44; &#60; 70&#44; &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; e o maior valor de &#954; &#61; 0&#44;90 para cLDL&#8208;M quando cLDL&#8208;D &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; o que poder&#225; permitir uma maior confian&#231;a quando avali&#225;mos o perfil lip&#237;dico de indiv&#237;duos de muito alto&#44; alto e moderado risco&#44; em que estes objetivos s&#227;o importantes de atingir&#44; estando em conson&#226;ncia com o encontrado no estudo original e num estudo populacional de valida&#231;&#227;o desta f&#243;rmula&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">12&#44;13</span></a> Em rela&#231;&#227;o aos valores &#60; 116<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; tal como encontrado noutro estudo&#44;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">15</span></a> o cLDL&#8208;F foi marginalmente mais concordante em compara&#231;&#227;o com o cLDL&#8208;M &#40;97&#44;4&#37; &#91;IC 95&#37;&#58; 96&#44;1&#8208;98&#44;3&#37;&#93; <span class="elsevierStyleItalic">vs&#46;</span> 97&#44;3&#37; &#91;IC 95&#37;&#58; 96&#44;0&#8208;98&#44;2&#37;&#93;&#41;&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Quando avali&#225;mos a discord&#226;ncia entre os valores calculados e o cLDL&#8208;D&#44; foi poss&#237;vel verificar que pela f&#243;rmula de Friedewald 60&#44;0&#37; e 29&#44;0&#37; dos participantes estariam dentro do alvo terap&#234;utico do muito alto e alto risco&#44; o que implicaria&#44; hipoteticamente&#44; um menor aprimoramento terap&#234;utica nestes casos&#46; No caso da f&#243;rmula de Martin&#8208;Hopkins foram encontradas discrep&#226;ncias menores&#44; o que tem sido encontrado noutros estudos&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">26&#44;27</span></a> No estudo de Palmer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">26</span></a> e Martin et al<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">27</span></a>&#44; a nova f&#243;rmula permitiu uma estimativa mais alta dos valores de cLDL em rela&#231;&#227;o &#224; f&#243;rmula de Friedewald&#44; particularmente nos doentes com baixos n&#237;veis de cLDL&#44; sendo salientado que o m&#233;todo de Martin&#8208;Hopkins pode prevenir o subtratamento devido &#224; subestima&#231;&#227;o do cLDL pelo m&#233;todo de Friedewald nesta faixa de valores&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Apesar de ser um pequeno grupo de indiv&#237;duos com Tgs acima ou igual a 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;n &#61; 12&#41;&#44; o coeficente &#961; e R<span class="elsevierStyleSup">2</span> encontrado foi forte &#40;&#62; 0&#44;9&#41; e significativo &#40;p &#60; 0&#44;001&#41;&#46; Estes resultados n&#227;o foram encontrados por Palmer et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">26</span></a> em que o novo m&#233;todo de c&#225;lculo do cLDL foi impreciso nos doentes com Tgs &#8805; 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL quando comparado com a determina&#231;&#227;o do cLDL por quantifica&#231;&#227;o &#946;&#46; No entanto&#44; ser&#227;o necess&#225;rios mais estudos para comprovar estes dados&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Resumidamente&#44; foram encontrados coeficientes de correla&#231;&#227;o e regress&#227;o linear superiores&#44; maior concord&#226;ncia e diferen&#231;as menores entre os valores de cLDL&#8208;M e cLDL&#8208;D em compara&#231;&#227;o com os valores de cLDL&#8208;F&#44; sobretudo nos grupos definidos com DM&#44; hipertrigliceridemia&#44; cLDL&#8208;D &#60; 70 e &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; sendo claro que o uso desta nova f&#243;rmula para estimar o cLDL &#233; uma melhoria em rela&#231;&#227;o &#224; f&#243;rmula mais amplamente usada de Friedewald&#46; De acordo com o descrito por Martin et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">12</span></a> alterar um c&#225;lculo &#233; uma quest&#227;o simples num laborat&#243;rio moderno&#44; podendo ser facilmente incorporado nos sistemas de relat&#243;rios laboratoriais automatizados praticamente sem custo adicional&#46; As 180 c&#233;lulas estratificadas &#40;<a class="elsevierStyleCrossRef" href="#sec0075">Anexo 1</a>&#41; podem ser adicionadas atrav&#233;s de um <span class="elsevierStyleItalic">software</span> dispon&#237;vel on&#8208;line &#40;<a href="http://ldlcalculator.com/">http&#58;&#47;&#47;ldlcalculator&#46;com&#47;</a>&#41; e&#44; assim&#44; facilmente implantado na maioria dos laborat&#243;rios cl&#237;nicos&#46; Apesar de ser uma f&#243;rmula que implica a consulta de uma tabela para o divisor vari&#225;vel dos Tgs&#44; na pr&#225;tica cl&#237;nica existe a possibilidade da utiliza&#231;&#227;o de uma aplica&#231;&#227;o m&#243;vel desenvolvida pelo Centro Ciccarone para a Preven&#231;&#227;o de Doen&#231;as Cardiovasculares do Hospital Johns Hopkins que permite a estimativa do cLDL pelo m&#233;todo de Martin&#8208;Hopkins &#40;<a href="https://www.hopkinsmedicine.org/apps/all-apps/ldl-cholesterol-calculator">https&#58;&#47;&#47;www&#46;hopkinsmedicine&#46;org&#47;apps&#47;all&#8208;apps&#47;ldl&#8208;cholesterol&#8208;calculator</a>&#41;&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">&#201; importante tamb&#233;m observar que o cLDL na pr&#225;tica cl&#237;nica &#233; um componente &#250;nico entre muitos dos fatores que determinam o risco de doen&#231;a cardiovascular de um indiv&#237;duo<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">1&#8211;4</span></a> e que a utiliza&#231;&#227;o do colesterol n&#227;o HDL como alvo terap&#234;utico permite que interfer&#234;ncias no c&#225;lculo do cLDL sejam minimizadas na decis&#227;o terap&#234;utica&#44; sendo recomendado particularmente em pessoas com altos n&#237;veis de Tgs&#44; DM&#44; obesidade ou n&#237;veis muito baixos de cLDL &#40;recomenda&#231;&#227;o grau I&#44; n&#237;vel C&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">3&#44;24</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Limita&#231;&#245;es</span><p id="par0165" class="elsevierStylePara elsevierViewall">Uma das limita&#231;&#245;es deste estudo foi o m&#233;todo de medi&#231;&#227;o direta do cLDL&#44; que n&#227;o foi o mesmo aplicado por Martin et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">12</span></a> que utilizou a ultracentrifuga&#231;&#227;o direta com perfil autom&#225;tico vertical &#40;VAP&#59; Atherotech&#41;&#44; e por Friedewald et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">6</span></a> que utilizou a quantifica&#231;&#227;o &#946;&#46; No entanto&#44; os m&#233;todos diretos &#40;ensaios homog&#233;neos de 3&#46;&#170; gera&#231;&#227;o&#41; para determina&#231;&#227;o do cLDL mostraram boa reprodutibilidade e certifica&#231;&#227;o pela Rede de Laborat&#243;rios de M&#233;todos de Refer&#234;ncia para o Colesterol &#40;<span class="elsevierStyleItalic">Cholesterol Reference Methods Laboratory Network</span> &#8211; CRMLN&#41; do Centro de Controlo e Preven&#231;&#227;o de Doen&#231;as &#40;CDC&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">28</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">No presente estudo foram avaliadas medi&#231;&#245;es &#250;nicas&#46; Portanto&#44; n&#227;o t&#234;m em conta a varia&#231;&#227;o individual dos n&#237;veis lip&#237;dicos&#46;</p><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Ponto&#8208;forte</span><p id="par0175" class="elsevierStylePara elsevierViewall">&#201; o primeiro estudo na popula&#231;&#227;o portuguesa que mostra a aplicabilidade da f&#243;rmula de Martin&#8208;Hopkins em rela&#231;&#227;o &#224; f&#243;rmula de Friedewald largamente usada no nosso Pa&#237;s&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conclus&#227;o</span><p id="par0180" class="elsevierStylePara elsevierViewall">A f&#243;rmula desenvolvida por Martin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">12</span></a> usa um fator ajust&#225;vel para a rela&#231;&#227;o Tgs&#47;VLDL&#44; que permite acur&#225;cia superior &#224; f&#243;rmula mais divulgada de Friedewald na estimativa da concentra&#231;&#227;o do cLDL&#46; A aplica&#231;&#227;o desta nova f&#243;rmula &#233; simples e v&#225;lida e teve um bom desempenho na nossa amostra&#44; mostrando superioridade em rela&#231;&#227;o &#224; f&#243;rmula de Friedewald&#44; sobretudo para valores de cLDL&#8208;D &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL e nos grupos definidos com diabetes <span class="elsevierStyleItalic">mellitus</span> e hipertrigliceridemia&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Financiamento</span><p id="par0185" class="elsevierStylePara elsevierViewall">Esta investiga&#231;&#227;o n&#227;o recebeu financiamento espec&#237;fico de qualquer setor comercial&#44; p&#250;blico ou sem fins lucrativos&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conflitos de interesse</span><p id="par0190" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflitos de interesses&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:14 [
        0 => array:3 [
          "identificador" => "xres1582546"
          "titulo" => "Resumo"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Introdu&#231;&#227;o"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Objetivo"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Material e m&#233;todos"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Resultados"
            ]
            4 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Conclus&#227;o"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1424394"
          "titulo" => "Palavras&#8208;chave"
        ]
        2 => array:3 [
          "identificador" => "xres1582545"
          "titulo" => "Abstract"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Introduction"
            ]
            1 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Aim"
            ]
            2 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Material and methods"
            ]
            3 => array:2 [
              "identificador" => "abst0045"
              "titulo" => "Results"
            ]
            4 => array:2 [
              "identificador" => "abst0050"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1424393"
          "titulo" => "Keywords"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introdu&#231;&#227;o"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Material e m&#233;todos"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Popula&#231;&#227;o do estudo"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Avalia&#231;&#245;es cl&#237;nicas"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Avalia&#231;&#245;es laboratoriais"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "An&#225;lise estat&#237;stica"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Resultados"
        ]
        7 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Discuss&#227;o"
        ]
        8 => array:3 [
          "identificador" => "sec0045"
          "titulo" => "Limita&#231;&#245;es"
          "secciones" => array:1 [
            0 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Ponto&#8208;forte"
            ]
          ]
        ]
        9 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Conclus&#227;o"
        ]
        10 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Financiamento"
        ]
        11 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conflitos de interesse"
        ]
        12 => array:2 [
          "identificador" => "xack558998"
          "titulo" => "Agradecimentos"
        ]
        13 => array:1 [
          "titulo" => "Refer&#234;ncias"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2020-08-22"
    "fechaAceptado" => "2020-11-06"
    "PalabrasClave" => array:2 [
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras&#8208;chave"
          "identificador" => "xpalclavsec1424394"
          "palabras" => array:6 [
            0 => "Colesterol LDL"
            1 => "F&#243;rmula Friedewald"
            2 => "F&#243;rmula Martin&#8208;Hopkins"
            3 => "Risco cardiovascular"
            4 => "Hipertrigliceridemia"
            5 => "Diabetes <span class="elsevierStyleItalic">mellitus</span>"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1424393"
          "palabras" => array:6 [
            0 => "LDL cholesterol"
            1 => "Friedewald formula"
            2 => "Martin&#8208;Hopkins formula"
            3 => "Cardiovascular risk"
            4 => "Hypertriglyceridemia"
            5 => "Diabetes <span class="elsevierStyleItalic">Mellitus</span>"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "pt" => array:3 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introdu&#231;&#227;o</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">O colesterol LDL &#40;cLDL&#41; &#233; essencial na abordagem do risco de doen&#231;as cardiovasculares&#46; Desde 1972 &#233; utilizada a f&#243;rmula de Friedewald para estimativa da concentra&#231;&#227;o do cLDL&#44; com algumas limita&#231;&#245;es&#46; Foi sugerida&#44; em 2013&#44; por Martin et al&#46;&#44; uma f&#243;rmula semelhante que permite melhor exatid&#227;o no c&#225;lculo do cLDL&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Mostrar aplicabilidade da nova f&#243;rmula&#44; que nome&#225;mos f&#243;rmula Martin&#8208;Hopkins&#44; na popula&#231;&#227;o portuguesa e comparar com a f&#243;rmula Friedewald utilizando o cLDL direto&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material e m&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudo transversal&#44; incluindo 1689 participantes do estudo e&#95;COR&#46; Aplic&#225;mos as f&#243;rmulas Martin&#8208;Hopkins e Friedewald para a estimativa de cLDL &#40;cLDL&#8208;M e cLDL&#8208;F&#41;&#46; A f&#243;rmula Friedewald n&#227;o foi aplicada em 12 casos por triglic&#233;ridos &#8805; 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46; Foi realizada a determina&#231;&#227;o direta do cLDL &#40;cLDL&#8208;D&#41;&#46; Resultados apresentados em mediana e amplitude interquartil&#46; N&#237;vel de signific&#226;ncia aceite p &#60; 0&#44;05&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Dos participantes&#44; 50&#44;2&#37; eram sexo masculino e mediana de 51 &#40;34&#41; anos&#46; O cLDL&#8208;D foi 117&#44;0 &#40;44&#44;0&#41; mg&#47;dL&#44; cLDL&#8208;M foi 114&#44;6 &#40;43&#44;7&#41; mg&#47;dL e cLDL&#8208;F foi 113&#44;8 &#40;43&#44;2&#41; mg&#47;dL&#46; O coeficiente de Spearman &#40;&#961;&#41; entre cLDL&#8208;M&#47;cLDL&#8208;D foi 0&#44;987 e entre cLDL&#8208;F&#47;cLDL&#8208;D foi 0&#44;983&#44; p &#61; 0&#44;001&#46; Esta forte correla&#231;&#227;o manteve&#8208;se no grupo com diabetes <span class="elsevierStyleItalic">mellitus</span> &#40;cLDL&#8208;M&#47;LDL&#8208;D &#961; &#61; 0&#44;987&#59; cLDL&#8208;F&#47;cLDL&#8208;D &#961; &#61; 0&#44;978&#44; p &#61; 0&#44;001&#41; e hipertrigliceridemia &#40;cLDL&#8208;M&#47;LDL&#8208;D &#961; &#61; 0&#44;983&#59; cLDL&#8208;F&#47;cLDL&#8208;D &#961; &#61; 0&#44;982&#44; p &#61; 0&#44;001&#41;&#46; Na an&#225;lise de concord&#226;ncia&#44; o maior valor de &#954; &#61; 0&#44;90 foi obtido para cLDL&#8208;M quando cLDL&#8208;D &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclus&#227;o</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A f&#243;rmula Martin&#8208;Hopkins teve um bom desempenho e aplicabilidade&#44; mostrando superioridade em rela&#231;&#227;o &#224; f&#243;rmula Friedewald&#44; sobretudo para valores de cLDL&#8208;D &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; diabetes <span class="elsevierStyleItalic">mellitus</span> e hipertrigliceridemia&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introdu&#231;&#227;o"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objetivo"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Material e m&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclus&#227;o"
          ]
        ]
      ]
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Low&#8208;density lipoprotein cholesterol &#40;LDL&#41; is essential in managing cardiovascular disease risk&#46; Since 1972&#44; the Friedewald formula has been used to estimate LDL concentration&#44; although with some limitations&#46; In 2013&#44; Martin et al&#46; proposed a similar but more accurate formula for calculating LDL&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Aim</span><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">To assess the applicability of the new formula&#44; which we have named the Martin&#8208;Hopkins formula&#44; in the Portuguese population and compare it with the Friedewald formula using direct LDL&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Material and methods</span><p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">Cross&#8208;sectional study&#44; including 1689 participants from the e&#95;COR study&#46; We applied the Martin&#8208;Hopkins and Friedewald formulas for estimated LDL &#40;LDL&#8208;M and LDL&#8208;F&#41;&#46; The Friedewald formula was not applied in 12 cases due to triglycerides &#8805;400mg&#47;dL&#46; Direct LDL was measured and the accepted significance level was p&#60;0&#46;05&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Results</span><p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">Of the total subjects&#44; 50&#46;2&#37; were male and had a median age of 51 &#40;34&#41; years&#46; LDL&#8208;D was 117&#46;0 &#40;44&#46;0&#41; mg&#47;dL&#44; LDL&#8208;M was 114&#46;6 &#40;43&#46;7&#41; mg&#47;dL and LDL&#8208;F was 113&#46;8 &#40;43&#46;2&#41; mg&#47;dL&#46; The Spearman coefficient &#40;&#961;&#41; between LDL&#8208;M&#47;LDL&#8208;D was 0&#46;987 and between LDL&#8208;F&#47;LDL&#8208;D was 0&#46;983&#44; p&#61;0&#46;001&#46; This strong correlation was maintained in the group with diabetes &#40;LDL&#8208;M&#47;LDL&#8208;D &#961;&#61;0&#46;987&#59; LDL&#8208;F&#47;LDL&#8208;D &#961;&#61;0&#46;978&#44; p&#61;0&#46;001&#41; and hypertriglyceridemia &#40;LDL&#8208;M&#47;LDL&#8208;D &#961;&#61;0&#46;983&#59; LDL&#8208;F&#47;LDL&#8208;D &#961;&#61;0&#46;982&#44; p&#61;0&#46;001&#41;&#46; In terms of agreement&#44; the highest value of &#954;&#61;0&#46;90 was obtained for LDL&#8208;M when LDL&#8208;D &#60;100 mg&#47;dL&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusion</span><p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">The Martin&#8208;Hopkins formula performed well and had good applicability&#44; showing superiority in relation to the Friedewald formula&#44; especially for LDL&#8208;D values &#60;100 mg&#47;dL&#44; diabetes&#44; and hypertriglyceridemia&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Aim"
          ]
          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Material and methods"
          ]
          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Results"
          ]
          4 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Conclusion"
          ]
        ]
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0205" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix B"
            "titulo" => "Material suplementar"
            "identificador" => "sec0075"
          ]
        ]
      ]
    ]
    "multimedia" => array:9 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1159
            "Ancho" => 2091
            "Tamanyo" => 170447
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Diagramas de caixas para compara&#231;&#227;o das medianas e amplitude interquartil do colesterol direto e calculado na popula&#231;&#227;o do estudo e nos v&#225;rios grupos&#46; <span class="elsevierStyleBold">1</span> &#8208; Compara&#231;&#227;o na popula&#231;&#227;o do estudo &#40;n &#61; 1677&#47;n &#61; 1689&#41;&#46; <span class="elsevierStyleBold">2</span> &#8208; Compara&#231;&#227;o no grupo sob terap&#234;utica antidislipid&#233;mica &#40;n &#61; 470&#47;n &#61; 474&#41;&#46; <span class="elsevierStyleBold">3</span> &#8208; Compara&#231;&#227;o no grupo sem terap&#234;utica antidislipid&#233;mica &#40;n &#61; 1&#46;207&#47;n &#61; 1&#46;215&#41;&#46; <span class="elsevierStyleBold">4</span> &#8208; Compara&#231;&#227;o no grupo com diabetes <span class="elsevierStyleItalic">mellitus</span> &#40;n &#61; 192&#47;n &#61; 198&#41;&#46; <span class="elsevierStyleBold">5</span> &#8208; Compara&#231;&#227;o no grupo com obesidade &#40;n &#61; 373&#47;n &#61; 382&#41;&#46; <span class="elsevierStyleBold">6</span> &#8208; Compara&#231;&#227;o no grupo com hipertriglicerid&#233;mia &#40;TGs &#8805; 150 e &#60; 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; &#40;n &#61; 276&#41;&#46; <span class="elsevierStyleBold">7</span> &#8211; Compara&#231;&#227;o no grupo com cLDL&#8208;D &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;n &#61; 82&#47;84&#41;&#46; cLD&#8208;D&#44; colesterol LDL direto&#46; cLDL&#8208;F&#44; colesterol LDL calculado pela f&#243;rmula de Friedewald&#46; cLDL&#8208;M&#44; colesterol LDL calculado pela f&#243;rmula de Martin&#8208;Hopkins&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2b.jpeg"
            "Alto" => 4339
            "Ancho" => 2925
            "Tamanyo" => 705190
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Gr&#225;ficos de dispers&#227;o relacionando o cLDL&#8208;D&#44; cLDL&#8208;F e o cLDL&#8208;M e o coeficiente de correla&#231;&#227;o entre estas vari&#225;veis na popula&#231;&#227;o do estudo e nos v&#225;rios grupos&#46; cLD&#8208;D&#44; colesterol LDL direto&#46; cLDL&#8208;F&#44; colesterol LDL calculado pela f&#243;rmula de Friedewald&#46; cLDL&#8208;M&#44; colesterol LDL calculado pela f&#243;rmula de Martin&#8208;Hopkins&#46; &#961;&#44; coeficiente de correla&#231;&#227;o &#961; de Spearman&#46; R<span class="elsevierStyleSup">2</span>&#44; regress&#227;o linear&#46; <elsevierMultimedia ident="202110050607203111"></elsevierMultimedia>&#44;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figura 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1709
            "Ancho" => 1258
            "Tamanyo" => 93068
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Gr&#225;fico de dispers&#227;o relacionando o cLDL&#8208;D e o cLDL&#8208;M e o coeficiente de correlac&#184;&#227;o entre estas vari&#225;veis nos indiv&#237;duos com triglic&#233;ridos &#8805; 400 mg&#47;dL&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabela 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">EAM&#44; enfarte agudo do mioc&#225;rdio&#46; HTA&#44; hipertens&#227;o arterial&#46; IMC&#44; &#237;ndice de massa corporal&#46; RFM&#44; massa gorda relativa&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade &#40;anos&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51 &#40;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#237;nimo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;ximo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Sexo &#40;n&#44; &#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">848 &#40;50&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">841 &#40;49&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">IMC &#40;kg&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#44;0 &#40;5&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#44;8 &#40;6&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">RFM &#40;&#37;&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#44;6 &#40;6&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#44;8 &#40;8&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HTA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">820 &#40;48&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Obesidade<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">382 &#40;22&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diabetes <span class="elsevierStyleItalic">mellitus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">198 &#40;11&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hist&#243;ria de EAM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;2&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sob terap&#234;utica para hipercolesterolemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">454 &#40;26&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sob terap&#234;utica para hipertrigliceridemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45 &#40;2&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2711024.png"
              ]
            ]
          ]
          "notaPie" => array:3 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Apresentado em mediana &#40;IQR&#41;&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Massa gorda relativa &#40;<span class="elsevierStyleItalic">Relative Fat Mass</span><a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">17</span></a>&#41; obtido atrav&#233;s da equa&#231;&#227;o 64 &#8208; &#40;20&#215;altura&#91;m&#93;&#47;cintura&#91;m&#93;&#41; &#43; &#40;12&#215;sexo&#91;0 se &#9794;&#59; 1 se &#9792;&#93;&#41;&#44; os pontos de corte para obesidade s&#227;o &#8805; 22&#44;8&#37; &#9794; e &#8805; 33&#44;9&#37; &#9792;&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Os ponto de corte aceite para definir obesidade nesta amostra foi IMC &#8805; 30&#44;0 kg&#47;m<span class="elsevierStyleSup">2</span>&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Dados demogr&#225;ficos e preval&#234;ncia de certas condi&#231;&#245;es na amostra</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Par&#226;metros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mediana &#40;IQR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Press&#227;o arterial sist&#243;lica &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">126&#44;5 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Press&#227;o arterial diast&#243;lica &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#44;5 &#40;15&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glic&#233;mia popula&#231;&#227;o do estudo &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91&#44;0 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glic&#233;mia nos diab&#233;ticos &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">135 &#40;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HbA1c popula&#231;&#227;o do estudo &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;4 &#40;0&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HbA1c nos diab&#233;ticos &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;0 &#40;1&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Creatinina &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;75 &#40;0&#44;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol total &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">192 &#40;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol HDL &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol LDL &#40;direto&#41; &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">117 &#40;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol LDL &#40;Friedewald&#41; &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">114 &#40;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol LDL &#40;Martin&#8208;Hopkins&#41; &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">115 &#40;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol n&#227;o&#8208;HDL &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">135 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Triglic&#233;ridos &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94 &#40;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2711026.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Par&#226;metros cl&#237;nicos e anal&#237;ticos avaliados na amostra e colesterol LDL calculado pelas f&#243;rmulas de Friedewald e de Martin&#8208;Hopkins</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabela 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">cLDL&#8208;D&#44; colesterol LDL direto&#59; cLDL&#8208;F&#44; colesterol LDL calculado pela f&#243;rmula de Friedewald&#59; cLDL&#8208;M&#44; colesterol LDL calculado pela f&#243;rmula de Martin&#8208;Hopkins&#46; Dif&#44; diferen&#231;a entre medianas&#46; IC&#44; intervalo de confian&#231;a&#46; IQR&#44; amplitude interquartil&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">cLDL&#8208;D&#44; mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">cLDL&#8208;F&#44; mg&#47;dL</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">cLDL&#8208;M&#44; mg&#47;dL</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Grupo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mediana &#40;IQR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mediana&#40;IQR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">dif&#40;IC 95&#37;&#41;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p&#8208;value</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mediana&#40;IQR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">dif&#40;IC 95&#37;&#41;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p&#8208;value</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8220;Sob terap&#234;utica antidislipid&#233;mica&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">107&#44;0 &#40;42&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">103&#44;0 &#40;43&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;3&#44;5 &#40;&#8208;4&#44;5 a &#8208;3&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">104&#44;1 &#40;43&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;2&#44;4 &#40;&#8208;2&#44;9 a &#8208;1&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8220;Sem terap&#234;utica antidislipid&#233;mica&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121&#44;0 &#40;44&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118&#44;0 &#40;43&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;2&#44;5 &#40;&#8208;3&#44;0 a &#8208;2&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118&#44;3 &#40;43&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;3&#44;0 &#40;&#8208;3&#44;4 a &#8208;2&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diabetes <span class="elsevierStyleItalic">mellitus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">106&#44;0 &#40;42&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98&#44;0&#40;44&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;5&#44;0 &#40;&#8208;6&#44;0 a &#8208;4&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">102&#44;6 &#40;41&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;2&#44;0 &#40;&#8208;2&#44;8 a &#8208;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Obesidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">125&#44;0 &#40;45&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118&#44;0 &#40;50&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;4&#44;5 &#40;&#8208;5&#44;5 a &#8208;4&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">123&#44;0 &#40;46&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;2&#44;4 &#40;&#8208;2&#44;9 a &#8208;1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hipertrigliceridemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">131&#44;0 &#40;46&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">122&#44;0 &#40;47&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;9&#44;0 &#40;&#8208;10&#44;0 a &#8208;8&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127&#44;7 &#40;45&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;2&#44;2 &#40;&#8208;3&#44;0 a &#8208;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">cLDL&#8208;D &#60; 70 mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&#44;0 &#40;10&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&#44;3 &#40;11&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;2&#44;2 &#40;&#8208;3&#44;3 a &#8208;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#44;4 &#40;11&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;1&#44;0 &#40;&#8208;2&#44;1 a 0&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;117&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2711025.png"
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Diferen&#231;a entre cLDL&#8208;F e cLDL&#8208;D&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0025"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Diferen&#231;a entre cLDL&#8208;M e cLDL&#8208;D&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Diferen&#231;a entre as medianas do colesterol calculado e direto nos v&#225;rios grupos da popula&#231;&#227;o do estudo que foram definidos segundo dados adquiridos no estudo e&#95;COR</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Tabela 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at4"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">cLDL&#8208;D&#44; colesterol LDL direto&#59; cLDL&#8208;F&#44; colesterol LDL calculado pela f&#243;rmula de Friedewald&#59; cLDL&#8208;M&#44; colesterol LDL calculado pela f&#243;rmula de Martin&#8208;Hopkins&#46; IC&#44; intervalo de confian&#231;a&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">cLDL&#8208;F</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">cLDL&#8208;M</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">cLDL&#8208;D&#44; mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">F&#47;D<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37; &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#954;<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p&#8208;valor</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">M&#47;D<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37; &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#954;<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p&#8208;valor</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 116&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">796&#47;817&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97&#44;4 &#40;96&#44;1&#8208;98&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">795&#47;817&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97&#44;3 &#40;96&#44;0&#8208;98&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">486&#47;503&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96&#44;6 &#40;94&#44;7&#8208;97&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">491&#47;503&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97&#44;6 &#40;95&#44;9&#8208;98&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&#47;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90&#44;5 &#40;82&#44;3&#8208;95&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77&#47;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91&#44;7 &#40;83&#44;9&#8208;95&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#47;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#44;0 &#40;50&#44;5&#8208;89&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#47;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#44;5 &#40;63&#44;9&#8208;96&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2711023.png"
              ]
            ]
          ]
          "notaPie" => array:3 [
            0 => array:3 [
              "identificador" => "tblfn0030"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0030">N&#250;mero de casos segundo a f&#243;rmula de Friedewald e o n&#250;mero de casos determinados pela medi&#231;&#227;o direta do colesterol LDL&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0035"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0035">N&#250;mero de casos segundo a f&#243;rmula de Martin&#8208;Hopkins e o n&#250;mero de casos determinados pela medi&#231;&#227;o direta do colesterol LDL&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0040"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0040">Valor da estat&#237;stica <span class="elsevierStyleItalic">kappa</span> de Cohen&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Concord&#226;ncia entre o colesterol calculado e direto segundo os alvos terap&#234;uticos para as categorias de risco cardiovascular segundo as linhas de orienta&#231;&#227;o da ESC&#47;EAS 2019<span class="elsevierStyleSup">3</span></p>"
        ]
      ]
      7 => array:5 [
        "identificador" => "upi0005"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc1.docx"
          "ficheroTamanyo" => 27510
        ]
      ]
      8 => array:5 [
        "identificador" => "202110050607203111"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2a.jpeg"
            "Alto" => 4089
            "Ancho" => 2925
            "Tamanyo" => 891738
          ]
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Refer&#234;ncias"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:28 [
            0 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Portugal&#46; Minist&#233;rio da Sa&#250;de&#46; Dire&#231;&#227;o&#8208;Geral da Sa&#250;de &#40;DGS&#41;&#46; Programa Nacional para as Doen&#231;as C&#233;rebro&#8208;Cardiovasculares&#46; Lisboa&#58; DGS&#59; 2017&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Portugal&#46; Minist&#233;rio da Sa&#250;de&#46; Dire&#231;&#227;o&#8208;Geral da Sa&#250;de &#40;DGS&#41;&#46; Abordagem Terap&#234;utica das Dislipidemias no Adulto&#46; Norma n&#176; 019&#47;2011&#46; Lisboa&#58; DGS&#59; 2017 may 11&#46;&#40;updated&#41;&#46;"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2019 ESC&#47;EAS Guidelines for the management of dyslipidaemias&#58; lipid modification to reduce cardiovascular risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "F&#46; Mach"
                            1 => "C&#46; Baigent"
                            2 => "A&#46; Catapano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurheartj/ehz455"
                      "Revista" => array:6 [
                        "tituloSerie" => "European Heart Journal&#46;"
                        "fecha" => "2019"
                        "volumen" => "41"
                        "paginaInicial" => "111"
                        "paginaFinal" => "188"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31504418"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2018 AHA&#47;ACC&#47;AACVPR&#47;AAPA&#47;ABC&#47;ACPM&#47;ADA&#47;AGS&#47;APhA&#47;ASPC&#47;NLA&#47;PCNA Guideline on the Management of Blood Cholesterol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Grundy"
                            1 => "N&#46; Stone"
                            2 => "A&#46; Bailey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2018.11.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of the American College of Cardiology&#46;"
                        "fecha" => "2019"
                        "volumen" => "73"
                        "paginaInicial" => "e285"
                        "paginaFinal" => "e350"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30423393"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Suboptimal lipid levels in clinical practice among Portuguese adults with dyslipidemia under lipid&#8208;lowering therapy&#58; Data from the DISGEN&#8208;LIPID study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; da Silva"
                            1 => "C&#46; Aguiar"
                            2 => "J&#46; Morais"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.repc.2019.02.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Port Cardiol&#46;"
                        "fecha" => "2019"
                        "volumen" => "38"
                        "paginaInicial" => "559"
                        "paginaFinal" => "569"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31706732"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estimation of the Concentration of Low&#8208;Density Lipoprotein Cholesterol in Plasma&#44; Without Use of the Preparative Ultracentrifuge"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46; Friedewald"
                            1 => "R&#46; Levy"
                            2 => "D&#46; Fredrickson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinical Chemistry&#46;"
                        "fecha" => "1972"
                        "volumen" => "18"
                        "paginaInicial" => "499"
                        "paginaFinal" => "502"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4337382"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Friedewald&#8208;Estimated Versus Directly Measured Low&#8208;Density Lipoprotein Cholesterol and Treatment Implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Martin"
                            1 => "M&#46; Blaha"
                            2 => "M&#46; Elshazly"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2013.01.079"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of the American College of Cardiology&#46;"
                        "fecha" => "2013"
                        "volumen" => "62"
                        "paginaInicial" => "732"
                        "paginaFinal" => "739"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23524048"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Underestimation of Low Density Lipoprotein&#8208;Cholesterol With the Friedewald Equation Versus a Direct Homogenous Low Density Lipoprotein&#8208;Cholesterol Assay"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "I&#46; Jialal"
                            1 => "M&#46; Inn"
                            2 => "D&#46; Siegel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/labmed/lmx023"
                      "Revista" => array:6 [
                        "tituloSerie" => "Laboratory Medicine&#46;"
                        "fecha" => "2017"
                        "volumen" => "48"
                        "paginaInicial" => "220"
                        "paginaFinal" => "224"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28398496"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low&#8208;Density Lipoprotein values estimated by Friedewald equation are affected by Diabetes control"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46; Vieira"
                            1 => "G&#46; Ara&#250;jo"
                            2 => "G&#46; Telo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "International Journal of Cardiovascular Sciences&#46;"
                        "fecha" => "2016"
                        "volumen" => "29"
                        "paginaInicial" => "348"
                        "paginaFinal" => "354"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Martin&#39;s&#44; Friedewald&#39;s and Cordova&#39;s formulas compared to LDL&#8208;C directly measured in Southern Brazil"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Cordova"
                            1 => "A&#46; Portal"
                            2 => "M&#46; Cordova"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Jornal Brasileiro de Patologia e Medicina Laboratorial&#46;"
                        "fecha" => "2020"
                        "volumen" => "56"
                        "paginaInicial" => "7"
                        "paginaFinal" => "12"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Martin&#39;s Equation as the Most Suitable Method for Estimation of Low&#8208;Density Lipoprotein Cholesterol Levels in Korean Adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Kang"
                            1 => "J&#46; Kim"
                            2 => "S&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Korean Journal of Family Medicine&#46;"
                        "fecha" => "2017"
                        "volumen" => "38"
                        "paginaInicial" => "263"
                        "paginaFinal" => "269"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of a Novel Method <span class="elsevierStyleItalic">vs</span> the Friedewald Equation for Estimating Low&#8208;Density Lipoprotein Cholesterol Levels From the Standard Lipid Profile"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Martin"
                            1 => "M&#46; Blaha"
                            2 => "M&#46; Elshazly"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2013.280532"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA&#46;"
                        "fecha" => "2013"
                        "volumen" => "310"
                        "paginaInicial" => "2061"
                        "paginaFinal" => "2068"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24240933"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of the Martin Method for Estimating Low&#8208;Density Lipoprotein Cholesterol Levels in Korean Adults&#58; Findings from the Korea National Health and Nutrition Examination Survey&#44; 2009&#8208;2011"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Lee"
                            1 => "S&#46; Jang"
                            2 => "H&#46; Son"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0148147"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLOS ONE&#46;"
                        "fecha" => "2016"
                        "volumen" => "11"
                        "paginaInicial" => "e0148147"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26824910"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Performance of LDL&#8208;C calculated with Martin&#39;s formula compared to the Friedewald equation in familial combined hyperlipidemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Mehta"
                            1 => "E&#46; Reyes-Rodr&#237;guez"
                            2 => "O&#46; Yaxmehen Bello-Chavolla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Atherosclerosis&#46;"
                        "fecha" => "2018"
                        "volumen" => "277"
                        "paginaInicial" => "204"
                        "paginaFinal" => "210"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of a Proposed Novel Equation for Estimating LDL Cholesterol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Meeusen"
                            1 => "A&#46; Lueke"
                            2 => "A&#46; Jaffe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clinical Chemistry&#46;"
                        "fecha" => "2014"
                        "volumen" => "60"
                        "paginaInicial" => "1519"
                        "paginaFinal" => "1523"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preval&#234;ncia de fatores de risco cardiovascular na popula&#231;&#227;o Portuguesa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Bourbon"
                            1 => "A&#46;C&#46; Alves"
                            2 => "Q&#46; Rato"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Instituto Nacional de Sa&#250;de Doutor Ricardo Jorge&#46; Lisboa&#59;"
                        "fecha" => "2019"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relative fat mass &#40;RFM&#41; as a new estimator of whole&#8208;body fat percentage <span class="elsevierStyleGlyphsbnd"></span> A cross&#8208;sectional study in American adult individuals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46; Woolcott"
                            1 => "R&#46; Bergman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/s41598-017-17765-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Scientific Reports&#46;"
                        "fecha" => "2018"
                        "volumen" => "8"
                        "paginaInicial" => "1"
                        "paginaFinal" => "11"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29311619"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Defining cutoffs to diagnose obesity using the relative fat mass &#40;RFM&#41;&#58; Association with mortality in NHANES 1999&#8208;2014"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46; Woolcott"
                            1 => "R&#46; Bergman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Obes &#40;Lond&#46;"
                        "fecha" => "2020"
                        "volumen" => "44"
                        "paginaInicial" => "1301"
                        "paginaFinal" => "1310"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Portugal&#46; Sociedade Portuguesa de Diabetologia &#40;SPD&#41;&#46; Diabetes&#58; Factos e N&#250;meros 2013 &#8722; Relat&#243;rio Anual do Observat&#243;rio Nacional da Diabetes&#46; Lisboa&#58; SPD&#59; 2013&#46;"
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estatinas&#58; utiliza&#231;&#227;o&#44; despesa e varia&#231;&#245;es regionais e internacionais entre 2000&#8208;2013"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Furtado"
                            1 => "R&#46; Oliveira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2014"
                        "editorial" => "INFARMED&#8208;Autoridade Nacional do Medicamento e Produtos de Sa&#250;de"
                        "editorialLocalizacion" => "Lisboa"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fasting Versus Nonfasting and Low&#8208;Density Lipoprotein Cholesterol Accuracy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "V&#46; Sathiyakumar"
                            1 => "J&#46; Park"
                            2 => "A&#46; Golozar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Circulation&#46;"
                        "fecha" => "2018"
                        "volumen" => "137"
                        "paginaInicial" => "10"
                        "paginaFinal" => "19"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of four different equations for calculating LDL&#8208;C with eight different direct HDL&#8208;C assays"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Oliveira"
                            1 => "H&#46; van Deventer"
                            2 => "L&#46; Bachmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clinica Chimica Acta&#46;"
                        "fecha" => "2013"
                        "volumen" => "423"
                        "paginaInicial" => "135"
                        "paginaFinal" => "140"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Friedewald Formula Underestimates LDL Cholesterol at low Concentrations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46; Scharnagl"
                            1 => "M&#46; Nauck"
                            2 => "H&#46; Wieland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1515/CCLM.2001.068"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chem Lab Med&#46;"
                        "fecha" => "2001"
                        "volumen" => "39"
                        "paginaInicial" => "426"
                        "paginaFinal" => "431"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11434393"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of the Martin&#47;Hopkins modified equation for estimating LDL&#8208;C on lipid target attainment in a high risk patient population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46; Cartier"
                            1 => "S&#46; St-Coeur"
                            2 => "A&#46; Robin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clinbiochem.2019.12.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinical Biochemistry&#46;"
                        "fecha" => "2020"
                        "volumen" => "76"
                        "paginaInicial" => "35"
                        "paginaFinal" => "37"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31843663"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validity of a Novel Method for Estimation of Low&#8208;Density Lipoprotein Cholesterol Levels in Diabetic Patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46; Chaen"
                            1 => "S&#46; Kinchiku"
                            2 => "M&#46; Miyata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5551/jat.35972"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Atherosclerosis and Thrombosis&#46;"
                        "fecha" => "2016"
                        "volumen" => "23"
                        "paginaInicial" => "1355"
                        "paginaFinal" => "1364"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27592628"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparing a novel equation for calculating low&#8208;density lipoprotein cholesterol with the Friedewald equation&#58; A VOYAGER analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Palmer"
                            1 => "P&#46; Barter"
                            2 => "P&#46; Lundman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clinbiochem.2018.10.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinical Biochemistry&#46;"
                        "fecha" => "2019"
                        "volumen" => "64"
                        "paginaInicial" => "24"
                        "paginaFinal" => "29"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30365923"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of Low&#8208;Density Lipoprotein Cholesterol Assessment by Martin&#47;Hopkins Estimation&#44; Friedewald Estimation&#44; and Preparative Ultracentrifugation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Martin"
                            1 => "R&#46; Giugliano"
                            2 => "S&#46; Murphy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamacardio.2018.1533"
                      "Revista" => array:5 [
                        "tituloSerie" => "JAMA Cardiology&#46;"
                        "fecha" => "2018"
                        "volumen" => "3"
                        "paginaInicial" => "749"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29898218"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Methods for Measurement of LDL&#8208;Cholesterol&#58; A Critical Assessment of Direct Measurement by Homogeneous Assays versus Calculation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Nauck"
                            1 => "G&#46; Warnick"
                            2 => "N&#46; Rifai"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinical Chemistry&#46;"
                        "fecha" => "2002"
                        "volumen" => "48"
                        "paginaInicial" => "236"
                        "paginaFinal" => "254"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11805004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack558998"
        "titulo" => "Agradecimentos"
        "texto" => "<p id="par0195" class="elsevierStylePara elsevierViewall">Aos participantes&#44; investigadores e t&#233;cnicos de an&#225;lises que trabalharam no projeto de investiga&#231;&#227;o do estudo e&#95;COR&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "pt"
  "url" => "/08702551/0000004000000010/v1_202110050607/S0870255121002419/v1_202110050607/pt/main.assets"
  "Apartado" => array:4 [
    "identificador" => "29261"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Artigos Originais"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08702551/0000004000000010/v1_202110050607/S0870255121002419/v1_202110050607/pt/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121002419?idApp=UINPBA00004E"
]
Partilhar
Número atual
Informação da revista
Voltar ao Artigo

Estatísticas

Siga este link para acessar o texto completo do artigo

Artigo original
Aplicabilidade da fórmula Martin‐Hopkins e comparação com a fórmula Friedewald na estimativa do colesterol LDL na população do estudo e_COR
Applicability of Martin‐Hopkins formula and comparison with Friedewald formula for estimated low‐density lipoprotein cholesterol in e_COR study population
Cátia Ferrinhoa,
Autor para correspondência
catia.ferrinho@gmail.com

Autor para correspondência.
, Ana Catarina Alvesb,c, Mafalda Bourbonb,c, Sequeira Duartea
a Serviço de Endocrinologia, Diabetes e Metabolismo do Hospital Egas Moniz, Lisboa, Portugal
b Unidade de Investigação e Desenvolvimento, Departamento de Promoção da Saúde e Prevenção de Doenças Não Transmissíveis, Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisboa, Portugal
c Center for Biodiversity, Functional & Integrative Genomics, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal
Lido
8640
Vezes
que se leu este artigo
1716
Total PDF
6924
Total HTML
Compartilhar estatísticas
 array:25 [
  "pii" => "S0870255121002419"
  "issn" => "08702551"
  "doi" => "10.1016/j.repc.2020.11.011"
  "estado" => "S300"
  "fechaPublicacion" => "2021-10-01"
  "aid" => "1758"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2021"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Cardiol. 2021;40:715-24"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "en" => array:20 [
      "pii" => "S2174204921001550"
      "issn" => "21742049"
      "doi" => "10.1016/j.repce.2021.07.001"
      "estado" => "S300"
      "fechaPublicacion" => "2021-10-01"
      "aid" => "1758"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Rev Port Cardiol. 2021;40:715-24"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
        "titulo" => "Applicability of Martin-Hopkins formula and comparison with Friedewald formula for estimated low-density lipoprotein cholesterol in e&#95;COR study population"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "pt"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "715"
            "paginaFinal" => "724"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "Aplicabilidade da f&#243;rmula Martin-Hopkins e compara&#231;&#227;o com a f&#243;rmula Friedewald na estimativa do colesterol LDL na popula&#231;&#227;o do estudo e&#95;COR"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "pt" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:8 [
            "identificador" => "fig0010"
            "etiqueta" => "Figure 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:2 [
              0 => array:1 [
                "imagen" => "gr2a.jpeg"
              ]
              1 => array:1 [
                "imagen" => "gr2b.jpeg"
              ]
            ]
            "detalles" => array:1 [
              0 => array:3 [
                "identificador" => "at0010"
                "detalle" => "Figure "
                "rol" => "short"
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Scatter plots relating LDL-D&#44; LDL-F and LDL-M cholesterol with the coefficient of comparision between these variables in the study population and in the various groups&#46;</p> <p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">LDL-D direct low-density lipoprotein cholesterol&#59; LDL-F&#58; low-density lipoprotein cholesterol calculated according to the Friedewald formula&#59; LDL-M&#58; low-density lipoprotein cholesterol calculated according to the Martin-Hopkins formula&#59; &#961;&#58; Spearman&#8217;s rank correlation coefficient&#59; R<span class="elsevierStyleSup">2</span>&#58; linear regression&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "C&#225;tia Ferrinho, Ana Catarina Alves, Mafalda Bourbon, Sequeira Duarte"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "C&#225;tia"
                "apellidos" => "Ferrinho"
              ]
              1 => array:2 [
                "nombre" => "Ana Catarina"
                "apellidos" => "Alves"
              ]
              2 => array:2 [
                "nombre" => "Mafalda"
                "apellidos" => "Bourbon"
              ]
              3 => array:2 [
                "nombre" => "Sequeira"
                "apellidos" => "Duarte"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "pt" => array:9 [
          "pii" => "S0870255121002419"
          "doi" => "10.1016/j.repc.2020.11.011"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "pt"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121002419?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921001550?idApp=UINPBA00004E"
      "url" => "/21742049/0000004000000010/v1_202111300755/S2174204921001550/v1_202111300755/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S0870255121002729"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2021.07.001"
    "estado" => "S300"
    "fechaPublicacion" => "2021-10-01"
    "aid" => "1780"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "dis"
    "cita" => "Rev Port Cardiol. 2021;40:725-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
      "titulo" => "In search of accurate estimates of low-density lipoprotein cholesterol levels &#8211; a better compass"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "725"
          "paginaFinal" => "726"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Em busca de estimativas corretas dos n&#237;veis de colesterol LDL &#8211; uma b&#250;ssola melhor"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ant&#243;nio Miguel Ferreira"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Ant&#243;nio Miguel"
              "apellidos" => "Ferreira"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2174204921002877"
        "doi" => "10.1016/j.repce.2021.10.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921002877?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121002729?idApp=UINPBA00004E"
    "url" => "/08702551/0000004000000010/v1_202110050607/S0870255121002729/v1_202110050607/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S0870255121002602"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2021.06.011"
    "estado" => "S300"
    "fechaPublicacion" => "2021-10-01"
    "aid" => "1777"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "dis"
    "cita" => "Rev Port Cardiol. 2021;40:713-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
      "titulo" => "Arterial switch operation for transposition of great arteries&#58; Is coronary artery circulation evaluation necessary&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "713"
          "paginaFinal" => "714"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "<span class="elsevierStyleItalic">Switch</span> arterial&#58; a avalia&#231;&#227;o da circula&#231;&#227;o coron&#225;ria &#233; necess&#225;ria&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ant&#243;nio Marinho-da-Silva"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Ant&#243;nio"
              "apellidos" => "Marinho-da-Silva"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2174204921002865"
        "doi" => "10.1016/j.repce.2021.10.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921002865?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121002602?idApp=UINPBA00004E"
    "url" => "/08702551/0000004000000010/v1_202110050607/S0870255121002602/v1_202110050607/en/main.assets"
  ]
  "pt" => array:21 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Artigo original</span>"
    "titulo" => "Aplicabilidade da f&#243;rmula Martin&#8208;Hopkins e compara&#231;&#227;o com a f&#243;rmula Friedewald na estimativa do colesterol LDL na popula&#231;&#227;o do estudo e&#95;COR"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "715"
        "paginaFinal" => "724"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#225;tia Ferrinho, Ana Catarina Alves, Mafalda Bourbon, Sequeira Duarte"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "C&#225;tia"
            "apellidos" => "Ferrinho"
            "email" => array:1 [
              0 => "catia.ferrinho@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Ana Catarina"
            "apellidos" => "Alves"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Mafalda"
            "apellidos" => "Bourbon"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Sequeira"
            "apellidos" => "Duarte"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servi&#231;o de Endocrinologia&#44; Diabetes e Metabolismo do Hospital Egas Moniz&#44; Lisboa&#44; Portugal"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidade de Investiga&#231;&#227;o e Desenvolvimento&#44; Departamento de Promo&#231;&#227;o da Sa&#250;de e Preven&#231;&#227;o de Doen&#231;as N&#227;o Transmiss&#237;veis&#44; Instituto Nacional de Sa&#250;de Doutor Ricardo Jorge&#44; Lisboa&#44; Portugal"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Center for Biodiversity&#44; Functional &#38; Integrative Genomics&#44; Faculdade de Ci&#234;ncias&#44; Universidade de Lisboa&#44; Lisboa&#44; Portugal"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Autor para correspond&#234;ncia&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Applicability of Martin&#8208;Hopkins formula and comparison with Friedewald formula for estimated low&#8208;density lipoprotein cholesterol in e&#95;COR study population"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1159
            "Ancho" => 2091
            "Tamanyo" => 170447
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Diagramas de caixas para compara&#231;&#227;o das medianas e amplitude interquartil do colesterol direto e calculado na popula&#231;&#227;o do estudo e nos v&#225;rios grupos&#46; <span class="elsevierStyleBold">1</span> &#8208; Compara&#231;&#227;o na popula&#231;&#227;o do estudo &#40;n &#61; 1677&#47;n &#61; 1689&#41;&#46; <span class="elsevierStyleBold">2</span> &#8208; Compara&#231;&#227;o no grupo sob terap&#234;utica antidislipid&#233;mica &#40;n &#61; 470&#47;n &#61; 474&#41;&#46; <span class="elsevierStyleBold">3</span> &#8208; Compara&#231;&#227;o no grupo sem terap&#234;utica antidislipid&#233;mica &#40;n &#61; 1&#46;207&#47;n &#61; 1&#46;215&#41;&#46; <span class="elsevierStyleBold">4</span> &#8208; Compara&#231;&#227;o no grupo com diabetes <span class="elsevierStyleItalic">mellitus</span> &#40;n &#61; 192&#47;n &#61; 198&#41;&#46; <span class="elsevierStyleBold">5</span> &#8208; Compara&#231;&#227;o no grupo com obesidade &#40;n &#61; 373&#47;n &#61; 382&#41;&#46; <span class="elsevierStyleBold">6</span> &#8208; Compara&#231;&#227;o no grupo com hipertriglicerid&#233;mia &#40;TGs &#8805; 150 e &#60; 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; &#40;n &#61; 276&#41;&#46; <span class="elsevierStyleBold">7</span> &#8211; Compara&#231;&#227;o no grupo com cLDL&#8208;D &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;n &#61; 82&#47;84&#41;&#46; cLD&#8208;D&#44; colesterol LDL direto&#46; cLDL&#8208;F&#44; colesterol LDL calculado pela f&#243;rmula de Friedewald&#46; cLDL&#8208;M&#44; colesterol LDL calculado pela f&#243;rmula de Martin&#8208;Hopkins&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introdu&#231;&#227;o</span><p id="par0010" class="elsevierStylePara elsevierViewall">A doen&#231;a cardiovascular ateroscler&#243;tica &#233; uma das principais causas de morbilidade e mortalidade em Portugal&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">O colesterol presente na lipoprote&#237;na de baixa densidade &#40;cLDL&#41; est&#225; associado &#224; forma&#231;&#227;o de placas ateroscler&#243;ticas e &#233; um importante fator de risco modific&#225;vel para doen&#231;a cardiovascular&#44; sendo utilizado como alvo terap&#234;utico prim&#225;rio em recomenda&#231;&#245;es nacionais e internacionais&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">2&#8211;4</span></a> O estudo Disgen&#8208;Lipid&#44; observacional de 24 centros de Portugal&#44; mostrou que o atingimento dos valores&#8208;alvo do cLDL foi sub&#243;timo e que &#233; necess&#225;ria uma abordagem mais vigorosa deste fator de risco&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">5</span></a> De acordo com as recomenda&#231;&#245;es da Sociedade Europeia de Cardiologia &#40;ESC&#41; e da Sociedade Europeia de Aterosclerose &#40;EAS&#41;&#44; os objetivos do cLDL para as diferentes categorias de risco s&#227;o redu&#231;&#227;o &#8805; 50&#37; do valor basal e um valor alvo de &#60; 55<span class="elsevierStyleHsp" style=""></span>mg&#47;dL se risco muito alto &#40;grau I&#44; n&#237;vel de evid&#234;ncia C&#41;&#44; redu&#231;&#227;o &#8805; 50&#37; do valor basal e um valor alvo de &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL se risco alto &#40;grau I&#44; n&#237;vel de evid&#234;ncia A&#41;&#44; &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL se risco moderado &#40;grau IIa&#44; n&#237;vel de evid&#234;ncia A&#41; e &#60; 116<span class="elsevierStyleHsp" style=""></span>mg&#47;dL se risco baixo &#40;grau IIb&#44; n&#237;vel de evid&#234;ncia A&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">O m&#233;todo de refer&#234;ncia para a determina&#231;&#227;o do cLDL &#233; a ultracentrifuga&#231;&#227;o e precipita&#231;&#227;o qu&#237;mica &#40;quantifica&#231;&#227;o &#946;&#41;&#44; um processo moroso&#44; dispendioso e pouco vi&#225;vel na pr&#225;tica cl&#237;nica&#46; Apesar da exist&#234;ncia de v&#225;rios m&#233;todos para a determina&#231;&#227;o direta da concentra&#231;&#227;o de LDL&#44; muitos laborat&#243;rios cl&#237;nicos utilizam a estimativa do cLDL pela simplicidade e aus&#234;ncia de custos&#44; sendo a f&#243;rmula de Friedewald a mais amplamente usada&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">3</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">A equa&#231;&#227;o de Friedewald baseia&#8208;se na subtra&#231;&#227;o do colesterol n&#227;o HDL pela varia&#231;&#227;o de VLDL numa rela&#231;&#227;o de 1&#58;5 de acordo com os triglic&#233;ridos &#40;Tgs&#41; e &#233; utilizada na pr&#225;tica cl&#237;nica desde 1972&#46; Esta propor&#231;&#227;o fixa pode levar a incorre&#231;&#245;es na estimativa de cLDL que poder&#227;o ter impacto na cl&#237;nica e em decis&#245;es terap&#234;uticas&#46; Foi salientado pelo pr&#243;prio autor que a simples divis&#227;o dos triglic&#233;ridos por cinco n&#227;o permite uma estimativa precisa da concentra&#231;&#227;o de VLDL e em v&#225;rias circunst&#226;ncias&#44; como Tgs acima de 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL e disbetalipoproteinemias&#44; esta f&#243;rmula n&#227;o pode ser aplicada&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">4&#44;6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">V&#225;rios estudos t&#234;m descrito a tend&#234;ncia da f&#243;rmula de Friedewald de subestimar os resultados do cLDL sobretudo naqueles com hipertrigliceridemia &#40;Tgs &#8805; 150<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; diabetes <span class="elsevierStyleItalic">mellitus</span>&#44; doen&#231;a hep&#225;tica alco&#243;lica e doen&#231;a renal cr&#243;nica em di&#225;lise&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">7&#8211;11</span></a> A subestima&#231;&#227;o pode ser problem&#225;tica&#44; podendo levar &#224; protela&#231;&#227;o de cuidados preventivos e terap&#234;uticos&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">7&#44;11</span></a> Por esta raz&#227;o&#44; v&#225;rios investigadores t&#234;m tentado modificar o r&#225;cio dos Tgs&#58;VLDL de forma a tornar a f&#243;rmula mais precisa e exata&#46; Em 2013&#44; Martin et al<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">12</span></a> sugeriram uma f&#243;rmula semelhante &#224; de Friedewald&#44; em que a estimativa do colesterol VLDL &#233; calculada pela divis&#227;o dos Tgs por um fator ajust&#225;vel que depende do valor do colesterol n&#227;o HDL e dos Tgs &#40;<a class="elsevierStyleCrossRef" href="#sec0075">Anexo 1</a>&#41;&#46; Estudos de valida&#231;&#227;o t&#234;m mostrado a sua superioridade &#224; f&#243;rmula original de Friedewald na estimativa da concentra&#231;&#227;o do cLDL em v&#225;rias popula&#231;&#245;es&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">11&#44;13&#8211;15</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Assim&#44; os objetivos do nosso trabalho foram mostrar a aplicabilidade da nova f&#243;rmula&#44; que nome&#225;mos f&#243;rmula de Martin&#8208;Hopkins&#44; numa amostra da popula&#231;&#227;o portuguesa&#44; comparar com a f&#243;rmula de Friedewald e determinar qual se aproxima mais do cLDL determinado por m&#233;todo laboratorial direto&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Material e m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Popula&#231;&#227;o do estudo</span><p id="par0045" class="elsevierStylePara elsevierViewall">Foram inclu&#237;dos 1689 participantes do estudo e&#95;COR&#44; que decorreu entre 2012 e 2014&#46; O estudo e&#95;COR foi populacional com componente laboratorial numa amostra aleat&#243;ria e estratificada por g&#233;nero e idade&#44; das cinco regi&#245;es de Portugal continental&#44; com o objetivo de obter dados representativos dos principais fatores de risco cardiovascular na popula&#231;&#227;o portuguesa&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">16</span></a> O estudo e&#95;COR foi aprovado pela Comiss&#227;o de &#201;tica do Instituto Nacional de Sa&#250;de Doutor Ricardo Jorge e pela Comiss&#227;o Nacional de Prote&#231;&#227;o de Dados&#46; Todos os procedimentos foram realizados de acordo com as boas pr&#225;ticas da Declara&#231;&#227;o de Hels&#237;nquia&#44; com a explica&#231;&#227;o e o preenchimento de consentimento informado&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Avalia&#231;&#245;es cl&#237;nicas</span><p id="par0050" class="elsevierStylePara elsevierViewall">Todos os participantes completaram um question&#225;rio que inclu&#237;a dados demogr&#225;ficos&#44; hist&#243;ria pessoal e familiar&#44; medica&#231;&#227;o habitual e h&#225;bitos comportamentais&#46; Foi avaliada a press&#227;o arterial &#40;em mmHg&#41;&#44; o peso &#40;em kg&#41;&#44; a altura &#40;em cm&#41; e o per&#237;metro da cintura &#40;em cm&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Avalia&#231;&#245;es laboratoriais</span><p id="par0055" class="elsevierStylePara elsevierViewall">As an&#225;lises de sangue foram obtidas ap&#243;s jejum de 12 horas e foram determinados v&#225;rios par&#226;metros bioqu&#237;micos&#46; A concentra&#231;&#227;o do cLDL foi determinada pelo m&#233;todo colorim&#233;trico direto no equipamento Cobas Integra&#174; 400<span class="elsevierStyleHsp" style=""></span>da Roche&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Aplicamos as f&#243;rmulas de Martin&#8208;Hopkins e Friedewald para a estimativa de cLDL &#40;<a class="elsevierStyleCrossRef" href="#sec0075">Anexo 1</a>&#41;&#46; A f&#243;rmula de Friedewald n&#227;o foi aplicada em 12 casos por triglic&#233;ridos &#8805; 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">An&#225;lise estat&#237;stica</span><p id="par0065" class="elsevierStylePara elsevierViewall">Os resultados s&#227;o apresentados em mediana e amplitude interquartil &#40;mediana &#91;IQR&#93;&#41;&#46; Dividimos a popula&#231;&#227;o do estudo em seis grupos para melhor caracteriza&#231;&#227;o das correla&#231;&#245;es e medianas segundo diferentes condi&#231;&#245;es &#40;<a class="elsevierStyleCrossRef" href="#sec0075">Anexo 2</a>&#41;&#46; Para a correla&#231;&#227;o entre o colesterol LDL direto &#40;cLDL&#8208;D&#41;&#44; colesterol LDL estimado pela f&#243;rmula de Friedewald &#40;cLDL&#8208;F&#41; e colesterol LDL estimado pela f&#243;rmula de Martin&#8208;Hopkins &#40;cLDL&#8208;M&#41; utilizou&#8208;se o coeficiente de correla&#231;&#227;o &#961; de Spearman e a regress&#227;o linear &#40;R<span class="elsevierStyleSup">2</span>&#41;&#46; Para avaliar as diferen&#231;as das medianas do cLDL&#8208;F e cLDL&#8208;M com o cLDL&#8208;D recorreu&#8208;se ao teste de Wilcoxon&#46; Na an&#225;lise da concord&#226;ncia do cLDL&#8208;F e cLDL&#8208;M com o cLDL&#8208;D de acordo com alvos terap&#234;uticos das linhas de orienta&#231;&#227;o da ESC&#47;EAS 2019<span class="elsevierStyleSup">3</span>&#44; empregou&#8208;se a estat&#237;stica <span class="elsevierStyleItalic">kappa</span> de Cohen &#40;&#954;&#41;&#46; O n&#237;vel de signific&#226;ncia aceite foi p &#60; 0&#44;05&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Resultados</span><p id="par0070" class="elsevierStylePara elsevierViewall">A idade mediana da popula&#231;&#227;o do estudo &#40;1689 participantes&#41; foi de 51 &#40;34&#41; anos e 50&#44;2&#37; da popula&#231;&#227;o eram do sexo masculino&#46; O IMC foi de 27&#44;0 &#40;5&#44;7&#41; kg&#47;m<span class="elsevierStyleSup">2</span> no sexo masculino e 25&#44;8 &#40;6&#44;7&#41; kg&#47;m<span class="elsevierStyleSup">2</span> no sexo feminino &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Tabela 1</a>&#41;&#46; Foi tamb&#233;m calculada para todos os participantes a massa de gordura relativa &#40;<span class="elsevierStyleItalic">Relative Fat Mass</span> &#8211; RFM&#41;&#46; A hipertens&#227;o arterial &#40;HTA&#41;&#44; a obesidade e diabetes <span class="elsevierStyleItalic">mellitus</span> &#40;DM&#41; estavam presentes em 48&#44;5&#37;&#44; 22&#44;6&#37; e 11&#44;7&#37; da popula&#231;&#227;o do estudo&#46; Estavam sob terap&#234;utica antidislipid&#233;mica 28&#44;1&#37; &#40;n &#61; 474&#41; dos participantes&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">O colesterol total e o colesterol HDL tiveram como mediana 192 &#40;48&#41; e 54 &#40;20&#41; mg&#47;dL&#44; respetivamente &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Tabela 2</a>&#41;&#46; A mediana do colesterol LDL direto &#40;cLDL&#8208;D&#41; foi 117&#44;0 &#40;44&#44;0&#41; mg&#47;dL&#59; a mediana do colesterol estimado cLDL&#8208;F foi 113&#44;8 &#40;43&#44;2&#41; mg&#47;dL com uma diferen&#231;a estatisticamente significativa de &#8208;3&#44;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;IC 95&#37;&#58; &#8208;3&#44;3 a &#8208;2&#44;8&#44; p &#60; 0&#44;001&#41; em rela&#231;&#227;o ao cLDL&#8208;D&#59; a mediana do colesterol estimado cLDL&#8208;M foi 114&#44;6 &#40;43&#44;7&#41; mg&#47;dL com uma diferen&#231;a estatisticamente significativa de &#8208;2&#44;8<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;IC 95&#37;&#58; &#8208;3&#44;1 a &#8208;2&#44;6&#44; p &#60; 0&#44;001&#41; em rela&#231;&#227;o ao cLDL&#8208;D&#46; Em rela&#231;&#227;o ao fator usado para o c&#225;lculo do cLDL&#8208;M a mediana foi de 4&#44;8 &#40;1&#44;1&#41;&#46; A mediana do colesterol n&#227;o HDL e dos triglic&#233;ridos foi 135 &#40;50&#41; mg&#47;dL e 94 &#40;60&#41; mg&#47;dL&#44; respetivamente&#46; Na amostra&#44; 12 participantes &#40;0&#44;7&#37;&#41; apresentaram triglic&#233;ridos &#8805; 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">A distribui&#231;&#227;o dos valores do cLDL direto e calculado para a popula&#231;&#227;o do estudo e para os diferentes grupos &#40;sob terap&#234;utica antidislipid&#233;mica&#44; sem terap&#234;utica antidislipid&#233;mica&#44; diabetes <span class="elsevierStyleItalic">mellitus</span>&#44; obesidade&#44; hipertrigliceridemia e cLDL&#8208;D &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; est&#225; representada na <a class="elsevierStyleCrossRef" href="#fig0005">Figura 1</a>&#46; Para os v&#225;rios grupos foram calculadas a mediana e a diferen&#231;a entre medianas do colesterol direto e calculado &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Tabela 3</a>&#41;&#46; Para todos os grupos foi poss&#237;vel verificar valores calculados pela f&#243;rmula de Friedewald mais baixos e diferen&#231;as maiores entre as medianas do cLDL&#8208;F e cLDL&#8208;D&#46; No grupo com cLDL&#8208;D &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL foi encontrada uma diferen&#231;a n&#227;o significativa de &#8208;0&#44;95 &#40;IC 95&#37;&#58; &#8208;2&#44;1 a 0&#44;2&#44; p &#61; 0&#44;117&#41; entre os valores calculados pela f&#243;rmula de Martin&#8208;Hopkins e o colesterol LDL direto&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Quando avaliamos a correla&#231;&#227;o entre as vari&#225;veis cLDL&#8208;F&#47;cLDL&#8208;D e cLDL&#8208;M&#47;cLDL&#8208;D na popula&#231;&#227;o do estudo e nos diferentes grupos verificou&#8208;se que em todos os casos as correla&#231;&#245;es s&#227;o estatisticamente significativas &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figura 2</a>&#41; e com valores superiores na correla&#231;&#227;o cLDL&#8208;M&#47;cLDL&#8208;D&#46; Estes valores foram muito pr&#243;ximos de 1 na popula&#231;&#227;o do estudo e em cinco grupos avaliados&#58; sob terap&#234;utica antidislipid&#233;mica&#44; sem terap&#234;utica antidislipid&#233;mica&#44; diabetes <span class="elsevierStyleItalic">mellitus</span>&#44; obesidade e hipertrigliceridemia &#40;valores de &#961; de Spearman para cLDL&#8208;F&#47;cLDL&#8208;D entre 0&#44;978 e 0&#44;983 e R<span class="elsevierStyleSup">2</span> entre 0&#44;966 e 0&#44;971&#59; para cLDL&#8208;M&#47;cLDL&#8208;D os valores de &#961; foram entre 0&#44;983 e 0&#44;988 e R<span class="elsevierStyleSup">2</span> entre 0&#44;976 e 0&#44;982&#41;&#46; No grupo com colesterol cLDL&#8208;D &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; a correla&#231;&#227;o &#961; e R<span class="elsevierStyleSup">2</span> foi inferior&#44; embora mostrando superioridade para a f&#243;rmula de Martin&#8208;Hopkins &#40;&#961; &#40;cLDL&#8208;F&#47;cLDL&#8208;D&#41; &#61; 0&#44;739&#44; R<span class="elsevierStyleSup">2</span> &#40;cLDL&#8208;F&#47;cLDL&#8208;D&#41; &#61; 0&#44;683&#59; &#961; &#40;cLDL&#8208;M&#47;cLDL&#8208;D&#41; &#61; 0&#44;769&#44; R<span class="elsevierStyleSup">2</span> &#40;cLDL&#8208;M&#47;cLDL&#8208;D&#41; &#61; 0&#44;758&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">A concord&#226;ncia do colesterol LDL calculado e direto foi realizada tendo em conta os alvos terap&#234;uticos de acordo com as linhas de orienta&#231;&#227;o da ESC&#47;EAS 2019 &#40;LDL &#60; 55&#44; &#60; 70&#44; &#60; 100&#44; &#60; 116<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">3</span></a>&#46; O n&#250;mero de casos estimados corretamente com valores abaixo destes alvos foi semelhante entre ambas as f&#243;rmulas &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Tabela 4</a>&#41;&#46; A maior diferen&#231;a percentual entre a concord&#226;ncia dos casos foi a favor da f&#243;rmula de Martin&#8208;Hopkins quando valores de cLDL&#8208;D &#60; 55<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;a f&#243;rmula de Friedewald classificou corretamente 75&#44;0&#37; &#91;IC 95&#37; 50&#44;5&#8208;89&#44;8 <span class="elsevierStyleItalic">versus</span> a f&#243;rmula de Martin&#8208;Hopkins&#44; que classificou corretamente 87&#44;5&#37; &#91;IC 95&#37; 63&#44;9&#8208;96&#44;5&#93; dos participantes neste alvo&#41;&#46; Nos outros alvos terap&#234;uticos verificou&#8208;se concord&#226;ncia superior a 90&#37; para as duas f&#243;rmulas&#46; O valor de <span class="elsevierStyleItalic">kappa</span> mostrou concord&#226;ncia &#171;excelente&#187; &#40;ou seja&#44; intervalo entre 0&#44;81 a 1&#41; nos n&#237;veis &#60; 70&#44; &#60; 100 e &#60; 116<span class="elsevierStyleHsp" style=""></span>mg&#47;dL para ambas as f&#243;rmulas&#46; Na categoria &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL foi obtido o maior valor de &#954; &#61; 0&#44;90 para a concord&#226;ncia entre o cLDL&#8208;M e o cLDL&#8208;D&#46; Em todos os casos a concord&#226;ncia teve signific&#226;ncia estat&#237;stica &#40;p &#60; 0&#44;001&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Quando avali&#225;mos a discord&#226;ncia entre o colesterol calculado e direto para os alvos terap&#234;uticos de risco muito alto e alto&#44; o cLDL&#8208;F categorizou 60&#44;0&#37; &#40;n &#61; 18&#41; dos casos de cLDL&#8208;D &#62; 55<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;n &#61; 30&#41; como dentro do alvo LDL &#60; 55<span class="elsevierStyleHsp" style=""></span>mg&#47;dL e 29&#44;0&#37; &#40;n &#61; 31&#41; dos casos de cLDL&#8208;D &#62; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;n &#61; 107&#41; como dentro do alvo LDL &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46; Para o cLDL&#8208;M&#44; a percentagem de discord&#226;ncia foi 36&#44;4&#37; &#40;n &#61; 8&#47;n &#61; 22&#41; e 25&#44;2&#37; &#40;n &#61; 26&#47;n &#61;103&#41;&#44; respetivamente&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Para os 12 casos nos quais n&#227;o foi aplicada a f&#243;rmula de Friedewald &#40;triglic&#233;ridos &#8805; 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; verificou&#8208;se&#44; como mostrado na <a class="elsevierStyleCrossRef" href="#fig0020">Figura 3</a>&#44; que a correla&#231;&#227;o entre o cLDL&#8208;M e o cLDL&#8208;D foi forte e com signific&#226;ncia estat&#237;stica &#40;&#961; &#61; 0&#44;916 e R<span class="elsevierStyleSup">2</span> &#61; 0&#44;955&#44; p &#60; 0&#44;001&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discuss&#227;o</span><p id="par0105" class="elsevierStylePara elsevierViewall">O colesterol LDL &#233; um alvo terap&#234;utico prim&#225;rio na preven&#231;&#227;o das doen&#231;as cardiovasculares &#40;DCV&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">2&#8211;4</span></a> Para esse fim &#233; necess&#225;ria acur&#225;cia na sua determina&#231;&#227;o&#46; O m&#233;todo de refer&#234;ncia para o doseamento do cLDL &#233; dispendioso e invi&#225;vel na pr&#225;tica cl&#237;nica&#46; Assim&#44; pela sua simplicidade &#233; utilizada h&#225; cerca de tr&#234;s d&#233;cadas a estimativa da concentra&#231;&#227;o de cLDL pela f&#243;rmula de Friedewald&#44; que tem sido refutada devido &#224; sua menor acur&#225;cia em situa&#231;&#245;es cl&#237;nicas como a hipertrigliceridemia e a diabetes <span class="elsevierStyleItalic">mellitus</span>&#46; O objetivo do presente trabalho foi aplicar uma nova f&#243;rmula que utiliza um r&#225;cio Tgs&#58;VLDL vari&#225;vel &#40;<a class="elsevierStyleCrossRef" href="#sec0075">Anexo 1</a>&#41; numa amostra da popula&#231;&#227;o portuguesa de um estudo nacional&#44; o estudo e&#95;COR&#44; da responsabilidade do Instituto Ricardo Jorge&#44; que decorreu entre 2012 e 2014&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">16</span></a> Esta nova f&#243;rmula &#40;classificada como f&#243;rmula de Martin&#8208;Hopkins&#41; tem mostrado acur&#225;cia superior &#224; de Friedewald em v&#225;rias popula&#231;&#245;es<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">11&#8211;13</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">No presente estudo&#44; a amostra em termos descritivos apresenta uma preval&#234;ncia dos sexos semelhante &#40;50&#44;2&#37; masculino e 49&#44;8&#37; feminino&#41;&#44; com idades entre 18 e 79&#44; com uma mediana de 51 &#40;34&#41; anos&#46; A mediana do IMC correspondeu a &#8220;excesso de peso&#8221; nos dois sexos &#40;IMC de 27&#44;0 &#91;5&#44;7&#93; kg&#47;m<span class="elsevierStyleSup">2</span> no sexo masculino e 25&#44;8 &#91;6&#44;7&#93; kg&#47;m<span class="elsevierStyleSup">2</span> no feminino&#41; e a mediana da massa de gordura relativa &#40;<span class="elsevierStyleItalic">Relative Fat Mass</span> &#8211; RFM<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">15</span></a>&#41; correspondeu a &#8220;obesidade&#8221; &#40;RFM de 28&#44;6 &#91;6&#44;6&#93;&#37; no sexo masculino e 40&#44;8 &#91;8&#44;2&#93;&#37; no sexo feminino&#41;&#46; O RFM &#233; um par&#226;metro que utiliza o per&#237;metro da cintura em vez do peso para definir obesidade&#44; sendo comprovada em v&#225;rios estudos a sua utilidade relativamente ao IMC&#44; com pontos de corte a serem definidos e validados consoante o tipo de popula&#231;&#227;o&#47;etnia&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">17&#44;18</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Em rela&#231;&#227;o aos fatores de risco para DCV&#44; verificou&#8208;se que quase metade dos participantes apresentava HTA &#40;48&#44;5&#37;&#41;&#46; A obesidade estava presente em 22&#44;6&#37; e a diabetes <span class="elsevierStyleItalic">mellitus</span> em 11&#44;7&#37; da amostra&#44; aproximando&#8208;se da preval&#234;ncia de DM em 2012 de 12&#44;9&#37; na popula&#231;&#227;o portuguesa&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">19</span></a> No entanto&#44; a preval&#234;ncia de DM na nossa amostra n&#227;o foi ajustada &#224; popula&#231;&#227;o portuguesa&#44; que&#44; de acordo com o relat&#243;rio do estudo e&#95;COR&#44; foi de 8&#44;9&#37; &#40;IC 95&#37;&#58; 7&#44;5&#8208;10&#44;3&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">16</span></a> Mais de um quarto da nossa amostra estava sob estatinas &#40;26&#44;9&#37;&#41;&#44; o que mostra a ampla utiliza&#231;&#227;o destes f&#225;rmacos em Portugal&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">20</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">A mediana dos valores doseados diretamente &#40;cLDL&#8208;D&#41; foi superior &#224; mediana dos valores estimados &#40;cLDL&#8208;F e cLDL&#8208;M&#41; na popula&#231;&#227;o do estudo&#44; com diferen&#231;a entre medianas estatisticamente significativa para os valores calculados pela f&#243;rmula de Friedewald de &#8208;3&#44;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;IC 95&#37;&#58; &#8208;3&#44;3 a &#8208;2&#44;8&#44; p &#60; 0&#44;001&#41; e para aqueles calculados pela f&#243;rmula de Martin&#8208;Hopkins de &#8208;2&#44;8<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;IC 95&#37;&#58; &#8208;3&#44;1 a &#8208;2&#44;6&#44; p &#60; 0&#44;001&#41;&#46; Apesar de um coeficiente de correla&#231;&#227;o forte&#44; houve dissemelhan&#231;as diferentes de zero em rela&#231;&#227;o &#224; determina&#231;&#227;o direta do cLDL para ambas as f&#243;rmulas&#46; As diferen&#231;as encontradas na popula&#231;&#227;o do estudo foram inferiores ao relatado noutros estudos e em outras popula&#231;&#245;es&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">11&#44;15</span></a> A mediana do r&#225;cio Tgs&#58;VLDL para o c&#225;lculo do cLDL&#8208;M foi de 4&#44;8 &#40;1&#44;1&#41;&#44; aproximando&#8208;se ao encontrado por Sathiyakumar et al&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">21</span></a> de 4&#44;9 &#40;4&#44;3&#8208;5&#44;7&#41;&#46; Este estudo avaliou o desempenho da f&#243;rmula de Martin&#8208;Hopkins <span class="elsevierStyleItalic">versus</span> a f&#243;rmula de Friedewald no estado de jejum e p&#243;s&#8208;prandial&#44; mostrando superioridade da f&#243;rmula de Martin&#8208;Hopkins nos dois estados&#46; Em compara&#231;&#227;o com o estudo de Martin et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">12</span></a> o nosso r&#225;cio foi inferior ao relatado de 5&#44;2 &#40;4&#44;5&#8208;6&#44;0&#41;&#44; sendo um fator dependente da composi&#231;&#227;o da popula&#231;&#227;o em an&#225;lise&#46; No entanto&#44; os r&#225;cios descritos s&#227;o pr&#243;ximos de 5&#44; o que explica a semelhan&#231;a no desempenho entre f&#243;rmulas no presente e nos estudos anteriormente referidos&#44; com superioridade em todos os casos para a f&#243;rmula de Martin&#8208;Hopkins&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">De acordo com estudos anteriores&#44; a tend&#234;ncia de subestimar os valores de cLDL pela f&#243;rmula de Friedewald ocorre sobretudo na presen&#231;a de DM&#44; hipertrigliceridemia e cLDL &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">7&#44;9&#44;22&#44;23</span></a> No nosso estudo verific&#225;mos a tend&#234;ncia para ambas as f&#243;rmulas de subestimar os valores de cLDL na popula&#231;&#227;o do estudo e nos grupos definidos &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figura 1</a> e <a class="elsevierStyleCrossRef" href="#tbl0015">Tabela 3</a>&#41;&#46; A mediana de cLDL&#8208;D mais elevada foi no grupo com hipertrigliceridemia &#40;cLDL&#8208;D de 131&#44;0 &#91;46&#44;0&#93; mg&#47;dL&#41;&#44; sendo neste grupo encontrada a diferen&#231;a mais significativa entre as medianas de cLDL&#8208;F e o cLDL&#8208;D de &#8208;9&#44;0<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;IC 95&#37;&#58; &#8208;10&#44;0 a &#8208;8&#44;5&#44; p &#60; 0&#44;001&#41;&#46; No grupo com DM a diferen&#231;a entre os valores de cLDL&#8208;F e o cLDL&#8208;D tamb&#233;m foi expressiva de &#8208;5&#44;0 &#40;IC 95&#37;&#58; &#8208;6&#44;0 a &#8208;4&#44;0&#44; p &#60; 0&#44;001&#41;&#46; Notavelmente&#44; os valores de cLDL&#8208;M estiveram mais pr&#243;ximos do cLDL&#8208;D nestes dois grupos&#58; &#8208;2&#44;2 &#40;IC 95&#37;&#58; &#8208;3&#44;0 a &#8208;1&#44;5&#44; p &#60; 0&#44;001&#41; para o grupo com hipertrigliceridemia e &#8208;2&#44;0 &#40;IC 95&#37;&#58; &#8208;2&#44;8 a &#8208;1&#44;3&#44; p &#60; 0&#44;001&#41; para o grupo com DM&#46; Estes resultados mostram a tend&#234;ncia da f&#243;rmula de Friedewald de subestimar os valores de cLDL quando estas condi&#231;&#245;es est&#227;o presentes e ser&#225; nestas condi&#231;&#245;es cl&#237;nicas que a f&#243;rmula de Martin&#8208;Hopkins poder&#225; ter mais utilidade&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">9&#44;24&#44;25</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Quando avali&#225;mos os coeficientes da correla&#231;&#227;o &#961; de Spearman e a regress&#227;o linear por grupos verific&#225;mos que em todos os casos estes foram superiores para os valores calculados pela f&#243;rmula de Martin&#8208;Hopkins em compara&#231;&#227;o com a f&#243;rmula de Friedewald&#44; variando os valores de cLDL&#8208;M de forma quase perfeita com os valores de cLDL&#8208;D nos grupos sob terap&#234;utica antidislipid&#233;mica&#44; sem terap&#234;utica antidislipid&#233;mica&#44; obesidade&#44; diabetes <span class="elsevierStyleItalic">mellitus</span> e hipertrigliceridemia&#44; mostrando uma correla&#231;&#227;o forte com os valores de cLDL&#8208;D &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figura 2</a>&#41;&#46; Para os valores de cLDL&#8208;F os coeficientes de correla&#231;&#227;o e regress&#227;o linear mostraram tamb&#233;m uma forte aproxima&#231;&#227;o com a varia&#231;&#227;o dos valores determinados de cLDL&#8208;D&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Para o cLDL&#8208;D &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; alvo terap&#234;utico de grau I e n&#237;vel de evid&#234;ncia A para indiv&#237;duos de alto risco de DCV&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">3</span></a> descrito noutros estudos como ponto de menor acur&#225;cia da f&#243;rmula de Friedewald&#44; <a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">8&#44;11&#44;13&#44;15&#44;22&#44;23</span></a> foi poss&#237;vel verificar uma correla&#231;&#227;o mais fraca em compara&#231;&#227;o com outros grupos para ambas as f&#243;rmulas&#44; com superioridade para a f&#243;rmula de Martin&#8208;Hopkins &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figura 2</a>&#41;&#46; A mediana de valores do cLDL&#8208;M neste grupo foi muito pr&#243;xima da mediana do cLDL&#8208;D&#44; com uma diferen&#231;a n&#227;o significativa de &#8208;0&#44;95 &#40;IC 95&#37;&#58; &#8208;2&#44;1 a 0&#44;2&#44; p &#61; 0&#44;117&#41;&#44; mostrando a superioridade da f&#243;rmula de Martin&#8208;Hopkins neste intervalo de valores&#44; o que tamb&#233;m foi validado em outros estudos&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">11&#44;13&#44;21&#44;24</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">Em rela&#231;&#227;o &#224; concord&#226;ncia do cLDL&#8208;M e do cLDL&#8208;F com o cLDL&#8208;D nos alvos terap&#234;uticos recomendados pela ESC&#47;EAS 2019&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">3</span></a> a exatid&#227;o foi menor &#224; medida que o valor de cLDL&#8208;D diminuiu para ambas as f&#243;rmulas&#46; No entanto&#44; verificou&#8208;se superioridade para a f&#243;rmula de Martin&#8208;Hopkins nos tr&#234;s primeiros alvos &#40;cLDL&#8208;D &#60; 55&#44; &#60; 70&#44; &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; e o maior valor de &#954; &#61; 0&#44;90 para cLDL&#8208;M quando cLDL&#8208;D &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; o que poder&#225; permitir uma maior confian&#231;a quando avali&#225;mos o perfil lip&#237;dico de indiv&#237;duos de muito alto&#44; alto e moderado risco&#44; em que estes objetivos s&#227;o importantes de atingir&#44; estando em conson&#226;ncia com o encontrado no estudo original e num estudo populacional de valida&#231;&#227;o desta f&#243;rmula&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">12&#44;13</span></a> Em rela&#231;&#227;o aos valores &#60; 116<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; tal como encontrado noutro estudo&#44;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">15</span></a> o cLDL&#8208;F foi marginalmente mais concordante em compara&#231;&#227;o com o cLDL&#8208;M &#40;97&#44;4&#37; &#91;IC 95&#37;&#58; 96&#44;1&#8208;98&#44;3&#37;&#93; <span class="elsevierStyleItalic">vs&#46;</span> 97&#44;3&#37; &#91;IC 95&#37;&#58; 96&#44;0&#8208;98&#44;2&#37;&#93;&#41;&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Quando avali&#225;mos a discord&#226;ncia entre os valores calculados e o cLDL&#8208;D&#44; foi poss&#237;vel verificar que pela f&#243;rmula de Friedewald 60&#44;0&#37; e 29&#44;0&#37; dos participantes estariam dentro do alvo terap&#234;utico do muito alto e alto risco&#44; o que implicaria&#44; hipoteticamente&#44; um menor aprimoramento terap&#234;utica nestes casos&#46; No caso da f&#243;rmula de Martin&#8208;Hopkins foram encontradas discrep&#226;ncias menores&#44; o que tem sido encontrado noutros estudos&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">26&#44;27</span></a> No estudo de Palmer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">26</span></a> e Martin et al<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">27</span></a>&#44; a nova f&#243;rmula permitiu uma estimativa mais alta dos valores de cLDL em rela&#231;&#227;o &#224; f&#243;rmula de Friedewald&#44; particularmente nos doentes com baixos n&#237;veis de cLDL&#44; sendo salientado que o m&#233;todo de Martin&#8208;Hopkins pode prevenir o subtratamento devido &#224; subestima&#231;&#227;o do cLDL pelo m&#233;todo de Friedewald nesta faixa de valores&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Apesar de ser um pequeno grupo de indiv&#237;duos com Tgs acima ou igual a 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;n &#61; 12&#41;&#44; o coeficente &#961; e R<span class="elsevierStyleSup">2</span> encontrado foi forte &#40;&#62; 0&#44;9&#41; e significativo &#40;p &#60; 0&#44;001&#41;&#46; Estes resultados n&#227;o foram encontrados por Palmer et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">26</span></a> em que o novo m&#233;todo de c&#225;lculo do cLDL foi impreciso nos doentes com Tgs &#8805; 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL quando comparado com a determina&#231;&#227;o do cLDL por quantifica&#231;&#227;o &#946;&#46; No entanto&#44; ser&#227;o necess&#225;rios mais estudos para comprovar estes dados&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Resumidamente&#44; foram encontrados coeficientes de correla&#231;&#227;o e regress&#227;o linear superiores&#44; maior concord&#226;ncia e diferen&#231;as menores entre os valores de cLDL&#8208;M e cLDL&#8208;D em compara&#231;&#227;o com os valores de cLDL&#8208;F&#44; sobretudo nos grupos definidos com DM&#44; hipertrigliceridemia&#44; cLDL&#8208;D &#60; 70 e &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; sendo claro que o uso desta nova f&#243;rmula para estimar o cLDL &#233; uma melhoria em rela&#231;&#227;o &#224; f&#243;rmula mais amplamente usada de Friedewald&#46; De acordo com o descrito por Martin et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">12</span></a> alterar um c&#225;lculo &#233; uma quest&#227;o simples num laborat&#243;rio moderno&#44; podendo ser facilmente incorporado nos sistemas de relat&#243;rios laboratoriais automatizados praticamente sem custo adicional&#46; As 180 c&#233;lulas estratificadas &#40;<a class="elsevierStyleCrossRef" href="#sec0075">Anexo 1</a>&#41; podem ser adicionadas atrav&#233;s de um <span class="elsevierStyleItalic">software</span> dispon&#237;vel on&#8208;line &#40;<a href="http://ldlcalculator.com/">http&#58;&#47;&#47;ldlcalculator&#46;com&#47;</a>&#41; e&#44; assim&#44; facilmente implantado na maioria dos laborat&#243;rios cl&#237;nicos&#46; Apesar de ser uma f&#243;rmula que implica a consulta de uma tabela para o divisor vari&#225;vel dos Tgs&#44; na pr&#225;tica cl&#237;nica existe a possibilidade da utiliza&#231;&#227;o de uma aplica&#231;&#227;o m&#243;vel desenvolvida pelo Centro Ciccarone para a Preven&#231;&#227;o de Doen&#231;as Cardiovasculares do Hospital Johns Hopkins que permite a estimativa do cLDL pelo m&#233;todo de Martin&#8208;Hopkins &#40;<a href="https://www.hopkinsmedicine.org/apps/all-apps/ldl-cholesterol-calculator">https&#58;&#47;&#47;www&#46;hopkinsmedicine&#46;org&#47;apps&#47;all&#8208;apps&#47;ldl&#8208;cholesterol&#8208;calculator</a>&#41;&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">&#201; importante tamb&#233;m observar que o cLDL na pr&#225;tica cl&#237;nica &#233; um componente &#250;nico entre muitos dos fatores que determinam o risco de doen&#231;a cardiovascular de um indiv&#237;duo<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">1&#8211;4</span></a> e que a utiliza&#231;&#227;o do colesterol n&#227;o HDL como alvo terap&#234;utico permite que interfer&#234;ncias no c&#225;lculo do cLDL sejam minimizadas na decis&#227;o terap&#234;utica&#44; sendo recomendado particularmente em pessoas com altos n&#237;veis de Tgs&#44; DM&#44; obesidade ou n&#237;veis muito baixos de cLDL &#40;recomenda&#231;&#227;o grau I&#44; n&#237;vel C&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">3&#44;24</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Limita&#231;&#245;es</span><p id="par0165" class="elsevierStylePara elsevierViewall">Uma das limita&#231;&#245;es deste estudo foi o m&#233;todo de medi&#231;&#227;o direta do cLDL&#44; que n&#227;o foi o mesmo aplicado por Martin et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">12</span></a> que utilizou a ultracentrifuga&#231;&#227;o direta com perfil autom&#225;tico vertical &#40;VAP&#59; Atherotech&#41;&#44; e por Friedewald et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">6</span></a> que utilizou a quantifica&#231;&#227;o &#946;&#46; No entanto&#44; os m&#233;todos diretos &#40;ensaios homog&#233;neos de 3&#46;&#170; gera&#231;&#227;o&#41; para determina&#231;&#227;o do cLDL mostraram boa reprodutibilidade e certifica&#231;&#227;o pela Rede de Laborat&#243;rios de M&#233;todos de Refer&#234;ncia para o Colesterol &#40;<span class="elsevierStyleItalic">Cholesterol Reference Methods Laboratory Network</span> &#8211; CRMLN&#41; do Centro de Controlo e Preven&#231;&#227;o de Doen&#231;as &#40;CDC&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">28</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">No presente estudo foram avaliadas medi&#231;&#245;es &#250;nicas&#46; Portanto&#44; n&#227;o t&#234;m em conta a varia&#231;&#227;o individual dos n&#237;veis lip&#237;dicos&#46;</p><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Ponto&#8208;forte</span><p id="par0175" class="elsevierStylePara elsevierViewall">&#201; o primeiro estudo na popula&#231;&#227;o portuguesa que mostra a aplicabilidade da f&#243;rmula de Martin&#8208;Hopkins em rela&#231;&#227;o &#224; f&#243;rmula de Friedewald largamente usada no nosso Pa&#237;s&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conclus&#227;o</span><p id="par0180" class="elsevierStylePara elsevierViewall">A f&#243;rmula desenvolvida por Martin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">12</span></a> usa um fator ajust&#225;vel para a rela&#231;&#227;o Tgs&#47;VLDL&#44; que permite acur&#225;cia superior &#224; f&#243;rmula mais divulgada de Friedewald na estimativa da concentra&#231;&#227;o do cLDL&#46; A aplica&#231;&#227;o desta nova f&#243;rmula &#233; simples e v&#225;lida e teve um bom desempenho na nossa amostra&#44; mostrando superioridade em rela&#231;&#227;o &#224; f&#243;rmula de Friedewald&#44; sobretudo para valores de cLDL&#8208;D &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL e nos grupos definidos com diabetes <span class="elsevierStyleItalic">mellitus</span> e hipertrigliceridemia&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Financiamento</span><p id="par0185" class="elsevierStylePara elsevierViewall">Esta investiga&#231;&#227;o n&#227;o recebeu financiamento espec&#237;fico de qualquer setor comercial&#44; p&#250;blico ou sem fins lucrativos&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conflitos de interesse</span><p id="par0190" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflitos de interesses&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:14 [
        0 => array:3 [
          "identificador" => "xres1582546"
          "titulo" => "Resumo"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Introdu&#231;&#227;o"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Objetivo"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Material e m&#233;todos"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Resultados"
            ]
            4 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Conclus&#227;o"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1424394"
          "titulo" => "Palavras&#8208;chave"
        ]
        2 => array:3 [
          "identificador" => "xres1582545"
          "titulo" => "Abstract"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Introduction"
            ]
            1 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Aim"
            ]
            2 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Material and methods"
            ]
            3 => array:2 [
              "identificador" => "abst0045"
              "titulo" => "Results"
            ]
            4 => array:2 [
              "identificador" => "abst0050"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1424393"
          "titulo" => "Keywords"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introdu&#231;&#227;o"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Material e m&#233;todos"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Popula&#231;&#227;o do estudo"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Avalia&#231;&#245;es cl&#237;nicas"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Avalia&#231;&#245;es laboratoriais"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "An&#225;lise estat&#237;stica"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Resultados"
        ]
        7 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Discuss&#227;o"
        ]
        8 => array:3 [
          "identificador" => "sec0045"
          "titulo" => "Limita&#231;&#245;es"
          "secciones" => array:1 [
            0 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Ponto&#8208;forte"
            ]
          ]
        ]
        9 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Conclus&#227;o"
        ]
        10 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Financiamento"
        ]
        11 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conflitos de interesse"
        ]
        12 => array:2 [
          "identificador" => "xack558998"
          "titulo" => "Agradecimentos"
        ]
        13 => array:1 [
          "titulo" => "Refer&#234;ncias"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2020-08-22"
    "fechaAceptado" => "2020-11-06"
    "PalabrasClave" => array:2 [
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras&#8208;chave"
          "identificador" => "xpalclavsec1424394"
          "palabras" => array:6 [
            0 => "Colesterol LDL"
            1 => "F&#243;rmula Friedewald"
            2 => "F&#243;rmula Martin&#8208;Hopkins"
            3 => "Risco cardiovascular"
            4 => "Hipertrigliceridemia"
            5 => "Diabetes <span class="elsevierStyleItalic">mellitus</span>"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1424393"
          "palabras" => array:6 [
            0 => "LDL cholesterol"
            1 => "Friedewald formula"
            2 => "Martin&#8208;Hopkins formula"
            3 => "Cardiovascular risk"
            4 => "Hypertriglyceridemia"
            5 => "Diabetes <span class="elsevierStyleItalic">Mellitus</span>"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "pt" => array:3 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introdu&#231;&#227;o</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">O colesterol LDL &#40;cLDL&#41; &#233; essencial na abordagem do risco de doen&#231;as cardiovasculares&#46; Desde 1972 &#233; utilizada a f&#243;rmula de Friedewald para estimativa da concentra&#231;&#227;o do cLDL&#44; com algumas limita&#231;&#245;es&#46; Foi sugerida&#44; em 2013&#44; por Martin et al&#46;&#44; uma f&#243;rmula semelhante que permite melhor exatid&#227;o no c&#225;lculo do cLDL&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Mostrar aplicabilidade da nova f&#243;rmula&#44; que nome&#225;mos f&#243;rmula Martin&#8208;Hopkins&#44; na popula&#231;&#227;o portuguesa e comparar com a f&#243;rmula Friedewald utilizando o cLDL direto&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material e m&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudo transversal&#44; incluindo 1689 participantes do estudo e&#95;COR&#46; Aplic&#225;mos as f&#243;rmulas Martin&#8208;Hopkins e Friedewald para a estimativa de cLDL &#40;cLDL&#8208;M e cLDL&#8208;F&#41;&#46; A f&#243;rmula Friedewald n&#227;o foi aplicada em 12 casos por triglic&#233;ridos &#8805; 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46; Foi realizada a determina&#231;&#227;o direta do cLDL &#40;cLDL&#8208;D&#41;&#46; Resultados apresentados em mediana e amplitude interquartil&#46; N&#237;vel de signific&#226;ncia aceite p &#60; 0&#44;05&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Dos participantes&#44; 50&#44;2&#37; eram sexo masculino e mediana de 51 &#40;34&#41; anos&#46; O cLDL&#8208;D foi 117&#44;0 &#40;44&#44;0&#41; mg&#47;dL&#44; cLDL&#8208;M foi 114&#44;6 &#40;43&#44;7&#41; mg&#47;dL e cLDL&#8208;F foi 113&#44;8 &#40;43&#44;2&#41; mg&#47;dL&#46; O coeficiente de Spearman &#40;&#961;&#41; entre cLDL&#8208;M&#47;cLDL&#8208;D foi 0&#44;987 e entre cLDL&#8208;F&#47;cLDL&#8208;D foi 0&#44;983&#44; p &#61; 0&#44;001&#46; Esta forte correla&#231;&#227;o manteve&#8208;se no grupo com diabetes <span class="elsevierStyleItalic">mellitus</span> &#40;cLDL&#8208;M&#47;LDL&#8208;D &#961; &#61; 0&#44;987&#59; cLDL&#8208;F&#47;cLDL&#8208;D &#961; &#61; 0&#44;978&#44; p &#61; 0&#44;001&#41; e hipertrigliceridemia &#40;cLDL&#8208;M&#47;LDL&#8208;D &#961; &#61; 0&#44;983&#59; cLDL&#8208;F&#47;cLDL&#8208;D &#961; &#61; 0&#44;982&#44; p &#61; 0&#44;001&#41;&#46; Na an&#225;lise de concord&#226;ncia&#44; o maior valor de &#954; &#61; 0&#44;90 foi obtido para cLDL&#8208;M quando cLDL&#8208;D &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclus&#227;o</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A f&#243;rmula Martin&#8208;Hopkins teve um bom desempenho e aplicabilidade&#44; mostrando superioridade em rela&#231;&#227;o &#224; f&#243;rmula Friedewald&#44; sobretudo para valores de cLDL&#8208;D &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; diabetes <span class="elsevierStyleItalic">mellitus</span> e hipertrigliceridemia&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introdu&#231;&#227;o"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objetivo"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Material e m&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclus&#227;o"
          ]
        ]
      ]
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Low&#8208;density lipoprotein cholesterol &#40;LDL&#41; is essential in managing cardiovascular disease risk&#46; Since 1972&#44; the Friedewald formula has been used to estimate LDL concentration&#44; although with some limitations&#46; In 2013&#44; Martin et al&#46; proposed a similar but more accurate formula for calculating LDL&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Aim</span><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">To assess the applicability of the new formula&#44; which we have named the Martin&#8208;Hopkins formula&#44; in the Portuguese population and compare it with the Friedewald formula using direct LDL&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Material and methods</span><p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">Cross&#8208;sectional study&#44; including 1689 participants from the e&#95;COR study&#46; We applied the Martin&#8208;Hopkins and Friedewald formulas for estimated LDL &#40;LDL&#8208;M and LDL&#8208;F&#41;&#46; The Friedewald formula was not applied in 12 cases due to triglycerides &#8805;400mg&#47;dL&#46; Direct LDL was measured and the accepted significance level was p&#60;0&#46;05&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Results</span><p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">Of the total subjects&#44; 50&#46;2&#37; were male and had a median age of 51 &#40;34&#41; years&#46; LDL&#8208;D was 117&#46;0 &#40;44&#46;0&#41; mg&#47;dL&#44; LDL&#8208;M was 114&#46;6 &#40;43&#46;7&#41; mg&#47;dL and LDL&#8208;F was 113&#46;8 &#40;43&#46;2&#41; mg&#47;dL&#46; The Spearman coefficient &#40;&#961;&#41; between LDL&#8208;M&#47;LDL&#8208;D was 0&#46;987 and between LDL&#8208;F&#47;LDL&#8208;D was 0&#46;983&#44; p&#61;0&#46;001&#46; This strong correlation was maintained in the group with diabetes &#40;LDL&#8208;M&#47;LDL&#8208;D &#961;&#61;0&#46;987&#59; LDL&#8208;F&#47;LDL&#8208;D &#961;&#61;0&#46;978&#44; p&#61;0&#46;001&#41; and hypertriglyceridemia &#40;LDL&#8208;M&#47;LDL&#8208;D &#961;&#61;0&#46;983&#59; LDL&#8208;F&#47;LDL&#8208;D &#961;&#61;0&#46;982&#44; p&#61;0&#46;001&#41;&#46; In terms of agreement&#44; the highest value of &#954;&#61;0&#46;90 was obtained for LDL&#8208;M when LDL&#8208;D &#60;100 mg&#47;dL&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusion</span><p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">The Martin&#8208;Hopkins formula performed well and had good applicability&#44; showing superiority in relation to the Friedewald formula&#44; especially for LDL&#8208;D values &#60;100 mg&#47;dL&#44; diabetes&#44; and hypertriglyceridemia&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Aim"
          ]
          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Material and methods"
          ]
          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Results"
          ]
          4 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Conclusion"
          ]
        ]
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0205" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix B"
            "titulo" => "Material suplementar"
            "identificador" => "sec0075"
          ]
        ]
      ]
    ]
    "multimedia" => array:9 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1159
            "Ancho" => 2091
            "Tamanyo" => 170447
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Diagramas de caixas para compara&#231;&#227;o das medianas e amplitude interquartil do colesterol direto e calculado na popula&#231;&#227;o do estudo e nos v&#225;rios grupos&#46; <span class="elsevierStyleBold">1</span> &#8208; Compara&#231;&#227;o na popula&#231;&#227;o do estudo &#40;n &#61; 1677&#47;n &#61; 1689&#41;&#46; <span class="elsevierStyleBold">2</span> &#8208; Compara&#231;&#227;o no grupo sob terap&#234;utica antidislipid&#233;mica &#40;n &#61; 470&#47;n &#61; 474&#41;&#46; <span class="elsevierStyleBold">3</span> &#8208; Compara&#231;&#227;o no grupo sem terap&#234;utica antidislipid&#233;mica &#40;n &#61; 1&#46;207&#47;n &#61; 1&#46;215&#41;&#46; <span class="elsevierStyleBold">4</span> &#8208; Compara&#231;&#227;o no grupo com diabetes <span class="elsevierStyleItalic">mellitus</span> &#40;n &#61; 192&#47;n &#61; 198&#41;&#46; <span class="elsevierStyleBold">5</span> &#8208; Compara&#231;&#227;o no grupo com obesidade &#40;n &#61; 373&#47;n &#61; 382&#41;&#46; <span class="elsevierStyleBold">6</span> &#8208; Compara&#231;&#227;o no grupo com hipertriglicerid&#233;mia &#40;TGs &#8805; 150 e &#60; 400<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; &#40;n &#61; 276&#41;&#46; <span class="elsevierStyleBold">7</span> &#8211; Compara&#231;&#227;o no grupo com cLDL&#8208;D &#60; 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;n &#61; 82&#47;84&#41;&#46; cLD&#8208;D&#44; colesterol LDL direto&#46; cLDL&#8208;F&#44; colesterol LDL calculado pela f&#243;rmula de Friedewald&#46; cLDL&#8208;M&#44; colesterol LDL calculado pela f&#243;rmula de Martin&#8208;Hopkins&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2b.jpeg"
            "Alto" => 4339
            "Ancho" => 2925
            "Tamanyo" => 705190
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Gr&#225;ficos de dispers&#227;o relacionando o cLDL&#8208;D&#44; cLDL&#8208;F e o cLDL&#8208;M e o coeficiente de correla&#231;&#227;o entre estas vari&#225;veis na popula&#231;&#227;o do estudo e nos v&#225;rios grupos&#46; cLD&#8208;D&#44; colesterol LDL direto&#46; cLDL&#8208;F&#44; colesterol LDL calculado pela f&#243;rmula de Friedewald&#46; cLDL&#8208;M&#44; colesterol LDL calculado pela f&#243;rmula de Martin&#8208;Hopkins&#46; &#961;&#44; coeficiente de correla&#231;&#227;o &#961; de Spearman&#46; R<span class="elsevierStyleSup">2</span>&#44; regress&#227;o linear&#46; <elsevierMultimedia ident="202110050607203111"></elsevierMultimedia>&#44;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figura 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1709
            "Ancho" => 1258
            "Tamanyo" => 93068
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Gr&#225;fico de dispers&#227;o relacionando o cLDL&#8208;D e o cLDL&#8208;M e o coeficiente de correlac&#184;&#227;o entre estas vari&#225;veis nos indiv&#237;duos com triglic&#233;ridos &#8805; 400 mg&#47;dL&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabela 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">EAM&#44; enfarte agudo do mioc&#225;rdio&#46; HTA&#44; hipertens&#227;o arterial&#46; IMC&#44; &#237;ndice de massa corporal&#46; RFM&#44; massa gorda relativa&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade &#40;anos&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51 &#40;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#237;nimo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;ximo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Sexo &#40;n&#44; &#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">848 &#40;50&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">841 &#40;49&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">IMC &#40;kg&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#44;0 &#40;5&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#44;8 &#40;6&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">RFM &#40;&#37;&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#44;6 &#40;6&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#44;8 &#40;8&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HTA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">820 &#40;48&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Obesidade<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">382 &#40;22&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diabetes <span class="elsevierStyleItalic">mellitus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">198 &#40;11&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hist&#243;ria de EAM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;2&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sob terap&#234;utica para hipercolesterolemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">454 &#40;26&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sob terap&#234;utica para hipertrigliceridemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45 &#40;2&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2711024.png"
              ]
            ]
          ]
          "notaPie" => array:3 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Apresentado em mediana &#40;IQR&#41;&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Massa gorda relativa &#40;<span class="elsevierStyleItalic">Relative Fat Mass</span><a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">17</span></a>&#41; obtido atrav&#233;s da equa&#231;&#227;o 64 &#8208; &#40;20&#215;altura&#91;m&#93;&#47;cintura&#91;m&#93;&#41; &#43; &#40;12&#215;sexo&#91;0 se &#9794;&#59; 1 se &#9792;&#93;&#41;&#44; os pontos de corte para obesidade s&#227;o &#8805; 22&#44;8&#37; &#9794; e &#8805; 33&#44;9&#37; &#9792;&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Os ponto de corte aceite para definir obesidade nesta amostra foi IMC &#8805; 30&#44;0 kg&#47;m<span class="elsevierStyleSup">2</span>&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Dados demogr&#225;ficos e preval&#234;ncia de certas condi&#231;&#245;es na amostra</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Par&#226;metros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mediana &#40;IQR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Press&#227;o arterial sist&#243;lica &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">126&#44;5 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Press&#227;o arterial diast&#243;lica &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#44;5 &#40;15&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glic&#233;mia popula&#231;&#227;o do estudo &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91&#44;0 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glic&#233;mia nos diab&#233;ticos &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">135 &#40;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HbA1c popula&#231;&#227;o do estudo &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;4 &#40;0&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HbA1c nos diab&#233;ticos &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;0 &#40;1&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Creatinina &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;75 &#40;0&#44;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol total &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">192 &#40;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol HDL &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol LDL &#40;direto&#41; &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">117 &#40;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol LDL &#40;Friedewald&#41; &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">114 &#40;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol LDL &#40;Martin&#8208;Hopkins&#41; &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">115 &#40;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol n&#227;o&#8208;HDL &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">135 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Triglic&#233;ridos &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94 &#40;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2711026.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Par&#226;metros cl&#237;nicos e anal&#237;ticos avaliados na amostra e colesterol LDL calculado pelas f&#243;rmulas de Friedewald e de Martin&#8208;Hopkins</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabela 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">cLDL&#8208;D&#44; colesterol LDL direto&#59; cLDL&#8208;F&#44; colesterol LDL calculado pela f&#243;rmula de Friedewald&#59; cLDL&#8208;M&#44; colesterol LDL calculado pela f&#243;rmula de Martin&#8208;Hopkins&#46; Dif&#44; diferen&#231;a entre medianas&#46; IC&#44; intervalo de confian&#231;a&#46; IQR&#44; amplitude interquartil&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">cLDL&#8208;D&#44; mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">cLDL&#8208;F&#44; mg&#47;dL</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">cLDL&#8208;M&#44; mg&#47;dL</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Grupo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mediana &#40;IQR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mediana&#40;IQR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">dif&#40;IC 95&#37;&#41;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p&#8208;value</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mediana&#40;IQR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">dif&#40;IC 95&#37;&#41;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p&#8208;value</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8220;Sob terap&#234;utica antidislipid&#233;mica&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">107&#44;0 &#40;42&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">103&#44;0 &#40;43&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;3&#44;5 &#40;&#8208;4&#44;5 a &#8208;3&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">104&#44;1 &#40;43&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;2&#44;4 &#40;&#8208;2&#44;9 a &#8208;1&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8220;Sem terap&#234;utica antidislipid&#233;mica&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121&#44;0 &#40;44&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118&#44;0 &#40;43&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;2&#44;5 &#40;&#8208;3&#44;0 a &#8208;2&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118&#44;3 &#40;43&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;3&#44;0 &#40;&#8208;3&#44;4 a &#8208;2&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diabetes <span class="elsevierStyleItalic">mellitus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">106&#44;0 &#40;42&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98&#44;0&#40;44&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;5&#44;0 &#40;&#8208;6&#44;0 a &#8208;4&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">102&#44;6 &#40;41&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;2&#44;0 &#40;&#8208;2&#44;8 a &#8208;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Obesidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">125&#44;0 &#40;45&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118&#44;0 &#40;50&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;4&#44;5 &#40;&#8208;5&#44;5 a &#8208;4&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">123&#44;0 &#40;46&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;2&#44;4 &#40;&#8208;2&#44;9 a &#8208;1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hipertrigliceridemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">131&#44;0 &#40;46&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">122&#44;0 &#40;47&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;9&#44;0 &#40;&#8208;10&#44;0 a &#8208;8&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127&#44;7 &#40;45&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;2&#44;2 &#40;&#8208;3&#44;0 a &#8208;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">cLDL&#8208;D &#60; 70 mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&#44;0 &#40;10&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&#44;3 &#40;11&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;2&#44;2 &#40;&#8208;3&#44;3 a &#8208;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#44;4 &#40;11&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;1&#44;0 &#40;&#8208;2&#44;1 a 0&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;117&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2711025.png"
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Diferen&#231;a entre cLDL&#8208;F e cLDL&#8208;D&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0025"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Diferen&#231;a entre cLDL&#8208;M e cLDL&#8208;D&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Diferen&#231;a entre as medianas do colesterol calculado e direto nos v&#225;rios grupos da popula&#231;&#227;o do estudo que foram definidos segundo dados adquiridos no estudo e&#95;COR</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Tabela 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at4"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">cLDL&#8208;D&#44; colesterol LDL direto&#59; cLDL&#8208;F&#44; colesterol LDL calculado pela f&#243;rmula de Friedewald&#59; cLDL&#8208;M&#44; colesterol LDL calculado pela f&#243;rmula de Martin&#8208;Hopkins&#46; IC&#44; intervalo de confian&#231;a&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">cLDL&#8208;F</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">cLDL&#8208;M</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">cLDL&#8208;D&#44; mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">F&#47;D<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37; &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#954;<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p&#8208;valor</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">M&#47;D<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37; &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#954;<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p&#8208;valor</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 116&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">796&#47;817&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97&#44;4 &#40;96&#44;1&#8208;98&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">795&#47;817&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97&#44;3 &#40;96&#44;0&#8208;98&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">486&#47;503&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96&#44;6 &#40;94&#44;7&#8208;97&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">491&#47;503&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97&#44;6 &#40;95&#44;9&#8208;98&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&#47;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90&#44;5 &#40;82&#44;3&#8208;95&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77&#47;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91&#44;7 &#40;83&#44;9&#8208;95&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#47;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#44;0 &#40;50&#44;5&#8208;89&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#47;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#44;5 &#40;63&#44;9&#8208;96&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2711023.png"
              ]
            ]
          ]
          "notaPie" => array:3 [
            0 => array:3 [
              "identificador" => "tblfn0030"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0030">N&#250;mero de casos segundo a f&#243;rmula de Friedewald e o n&#250;mero de casos determinados pela medi&#231;&#227;o direta do colesterol LDL&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0035"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0035">N&#250;mero de casos segundo a f&#243;rmula de Martin&#8208;Hopkins e o n&#250;mero de casos determinados pela medi&#231;&#227;o direta do colesterol LDL&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0040"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0040">Valor da estat&#237;stica <span class="elsevierStyleItalic">kappa</span> de Cohen&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Concord&#226;ncia entre o colesterol calculado e direto segundo os alvos terap&#234;uticos para as categorias de risco cardiovascular segundo as linhas de orienta&#231;&#227;o da ESC&#47;EAS 2019<span class="elsevierStyleSup">3</span></p>"
        ]
      ]
      7 => array:5 [
        "identificador" => "upi0005"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc1.docx"
          "ficheroTamanyo" => 27510
        ]
      ]
      8 => array:5 [
        "identificador" => "202110050607203111"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2a.jpeg"
            "Alto" => 4089
            "Ancho" => 2925
            "Tamanyo" => 891738
          ]
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Refer&#234;ncias"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:28 [
            0 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Portugal&#46; Minist&#233;rio da Sa&#250;de&#46; Dire&#231;&#227;o&#8208;Geral da Sa&#250;de &#40;DGS&#41;&#46; Programa Nacional para as Doen&#231;as C&#233;rebro&#8208;Cardiovasculares&#46; Lisboa&#58; DGS&#59; 2017&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Portugal&#46; Minist&#233;rio da Sa&#250;de&#46; Dire&#231;&#227;o&#8208;Geral da Sa&#250;de &#40;DGS&#41;&#46; Abordagem Terap&#234;utica das Dislipidemias no Adulto&#46; Norma n&#176; 019&#47;2011&#46; Lisboa&#58; DGS&#59; 2017 may 11&#46;&#40;updated&#41;&#46;"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2019 ESC&#47;EAS Guidelines for the management of dyslipidaemias&#58; lipid modification to reduce cardiovascular risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "F&#46; Mach"
                            1 => "C&#46; Baigent"
                            2 => "A&#46; Catapano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurheartj/ehz455"
                      "Revista" => array:6 [
                        "tituloSerie" => "European Heart Journal&#46;"
                        "fecha" => "2019"
                        "volumen" => "41"
                        "paginaInicial" => "111"
                        "paginaFinal" => "188"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31504418"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2018 AHA&#47;ACC&#47;AACVPR&#47;AAPA&#47;ABC&#47;ACPM&#47;ADA&#47;AGS&#47;APhA&#47;ASPC&#47;NLA&#47;PCNA Guideline on the Management of Blood Cholesterol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Grundy"
                            1 => "N&#46; Stone"
                            2 => "A&#46; Bailey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2018.11.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of the American College of Cardiology&#46;"
                        "fecha" => "2019"
                        "volumen" => "73"
                        "paginaInicial" => "e285"
                        "paginaFinal" => "e350"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30423393"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Suboptimal lipid levels in clinical practice among Portuguese adults with dyslipidemia under lipid&#8208;lowering therapy&#58; Data from the DISGEN&#8208;LIPID study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; da Silva"
                            1 => "C&#46; Aguiar"
                            2 => "J&#46; Morais"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.repc.2019.02.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Port Cardiol&#46;"
                        "fecha" => "2019"
                        "volumen" => "38"
                        "paginaInicial" => "559"
                        "paginaFinal" => "569"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31706732"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estimation of the Concentration of Low&#8208;Density Lipoprotein Cholesterol in Plasma&#44; Without Use of the Preparative Ultracentrifuge"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46; Friedewald"
                            1 => "R&#46; Levy"
                            2 => "D&#46; Fredrickson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinical Chemistry&#46;"
                        "fecha" => "1972"
                        "volumen" => "18"
                        "paginaInicial" => "499"
                        "paginaFinal" => "502"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4337382"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Friedewald&#8208;Estimated Versus Directly Measured Low&#8208;Density Lipoprotein Cholesterol and Treatment Implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Martin"
                            1 => "M&#46; Blaha"
                            2 => "M&#46; Elshazly"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2013.01.079"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of the American College of Cardiology&#46;"
                        "fecha" => "2013"
                        "volumen" => "62"
                        "paginaInicial" => "732"
                        "paginaFinal" => "739"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23524048"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Underestimation of Low Density Lipoprotein&#8208;Cholesterol With the Friedewald Equation Versus a Direct Homogenous Low Density Lipoprotein&#8208;Cholesterol Assay"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "I&#46; Jialal"
                            1 => "M&#46; Inn"
                            2 => "D&#46; Siegel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/labmed/lmx023"
                      "Revista" => array:6 [
                        "tituloSerie" => "Laboratory Medicine&#46;"
                        "fecha" => "2017"
                        "volumen" => "48"
                        "paginaInicial" => "220"
                        "paginaFinal" => "224"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28398496"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low&#8208;Density Lipoprotein values estimated by Friedewald equation are affected by Diabetes control"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46; Vieira"
                            1 => "G&#46; Ara&#250;jo"
                            2 => "G&#46; Telo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "International Journal of Cardiovascular Sciences&#46;"
                        "fecha" => "2016"
                        "volumen" => "29"
                        "paginaInicial" => "348"
                        "paginaFinal" => "354"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Martin&#39;s&#44; Friedewald&#39;s and Cordova&#39;s formulas compared to LDL&#8208;C directly measured in Southern Brazil"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Cordova"
                            1 => "A&#46; Portal"
                            2 => "M&#46; Cordova"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Jornal Brasileiro de Patologia e Medicina Laboratorial&#46;"
                        "fecha" => "2020"
                        "volumen" => "56"
                        "paginaInicial" => "7"
                        "paginaFinal" => "12"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Martin&#39;s Equation as the Most Suitable Method for Estimation of Low&#8208;Density Lipoprotein Cholesterol Levels in Korean Adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Kang"
                            1 => "J&#46; Kim"
                            2 => "S&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Korean Journal of Family Medicine&#46;"
                        "fecha" => "2017"
                        "volumen" => "38"
                        "paginaInicial" => "263"
                        "paginaFinal" => "269"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of a Novel Method <span class="elsevierStyleItalic">vs</span> the Friedewald Equation for Estimating Low&#8208;Density Lipoprotein Cholesterol Levels From the Standard Lipid Profile"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Martin"
                            1 => "M&#46; Blaha"
                            2 => "M&#46; Elshazly"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2013.280532"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA&#46;"
                        "fecha" => "2013"
                        "volumen" => "310"
                        "paginaInicial" => "2061"
                        "paginaFinal" => "2068"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24240933"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of the Martin Method for Estimating Low&#8208;Density Lipoprotein Cholesterol Levels in Korean Adults&#58; Findings from the Korea National Health and Nutrition Examination Survey&#44; 2009&#8208;2011"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Lee"
                            1 => "S&#46; Jang"
                            2 => "H&#46; Son"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0148147"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLOS ONE&#46;"
                        "fecha" => "2016"
                        "volumen" => "11"
                        "paginaInicial" => "e0148147"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26824910"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Performance of LDL&#8208;C calculated with Martin&#39;s formula compared to the Friedewald equation in familial combined hyperlipidemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Mehta"
                            1 => "E&#46; Reyes-Rodr&#237;guez"
                            2 => "O&#46; Yaxmehen Bello-Chavolla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Atherosclerosis&#46;"
                        "fecha" => "2018"
                        "volumen" => "277"
                        "paginaInicial" => "204"
                        "paginaFinal" => "210"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of a Proposed Novel Equation for Estimating LDL Cholesterol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Meeusen"
                            1 => "A&#46; Lueke"
                            2 => "A&#46; Jaffe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clinical Chemistry&#46;"
                        "fecha" => "2014"
                        "volumen" => "60"
                        "paginaInicial" => "1519"
                        "paginaFinal" => "1523"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preval&#234;ncia de fatores de risco cardiovascular na popula&#231;&#227;o Portuguesa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Bourbon"
                            1 => "A&#46;C&#46; Alves"
                            2 => "Q&#46; Rato"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Instituto Nacional de Sa&#250;de Doutor Ricardo Jorge&#46; Lisboa&#59;"
                        "fecha" => "2019"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relative fat mass &#40;RFM&#41; as a new estimator of whole&#8208;body fat percentage <span class="elsevierStyleGlyphsbnd"></span> A cross&#8208;sectional study in American adult individuals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46; Woolcott"
                            1 => "R&#46; Bergman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/s41598-017-17765-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Scientific Reports&#46;"
                        "fecha" => "2018"
                        "volumen" => "8"
                        "paginaInicial" => "1"
                        "paginaFinal" => "11"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29311619"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Defining cutoffs to diagnose obesity using the relative fat mass &#40;RFM&#41;&#58; Association with mortality in NHANES 1999&#8208;2014"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46; Woolcott"
                            1 => "R&#46; Bergman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Obes &#40;Lond&#46;"
                        "fecha" => "2020"
                        "volumen" => "44"
                        "paginaInicial" => "1301"
                        "paginaFinal" => "1310"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Portugal&#46; Sociedade Portuguesa de Diabetologia &#40;SPD&#41;&#46; Diabetes&#58; Factos e N&#250;meros 2013 &#8722; Relat&#243;rio Anual do Observat&#243;rio Nacional da Diabetes&#46; Lisboa&#58; SPD&#59; 2013&#46;"
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estatinas&#58; utiliza&#231;&#227;o&#44; despesa e varia&#231;&#245;es regionais e internacionais entre 2000&#8208;2013"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Furtado"
                            1 => "R&#46; Oliveira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2014"
                        "editorial" => "INFARMED&#8208;Autoridade Nacional do Medicamento e Produtos de Sa&#250;de"
                        "editorialLocalizacion" => "Lisboa"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fasting Versus Nonfasting and Low&#8208;Density Lipoprotein Cholesterol Accuracy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "V&#46; Sathiyakumar"
                            1 => "J&#46; Park"
                            2 => "A&#46; Golozar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Circulation&#46;"
                        "fecha" => "2018"
                        "volumen" => "137"
                        "paginaInicial" => "10"
                        "paginaFinal" => "19"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of four different equations for calculating LDL&#8208;C with eight different direct HDL&#8208;C assays"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Oliveira"
                            1 => "H&#46; van Deventer"
                            2 => "L&#46; Bachmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clinica Chimica Acta&#46;"
                        "fecha" => "2013"
                        "volumen" => "423"
                        "paginaInicial" => "135"
                        "paginaFinal" => "140"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Friedewald Formula Underestimates LDL Cholesterol at low Concentrations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46; Scharnagl"
                            1 => "M&#46; Nauck"
                            2 => "H&#46; Wieland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1515/CCLM.2001.068"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chem Lab Med&#46;"
                        "fecha" => "2001"
                        "volumen" => "39"
                        "paginaInicial" => "426"
                        "paginaFinal" => "431"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11434393"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of the Martin&#47;Hopkins modified equation for estimating LDL&#8208;C on lipid target attainment in a high risk patient population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46; Cartier"
                            1 => "S&#46; St-Coeur"
                            2 => "A&#46; Robin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clinbiochem.2019.12.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinical Biochemistry&#46;"
                        "fecha" => "2020"
                        "volumen" => "76"
                        "paginaInicial" => "35"
                        "paginaFinal" => "37"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31843663"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validity of a Novel Method for Estimation of Low&#8208;Density Lipoprotein Cholesterol Levels in Diabetic Patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46; Chaen"
                            1 => "S&#46; Kinchiku"
                            2 => "M&#46; Miyata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5551/jat.35972"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Atherosclerosis and Thrombosis&#46;"
                        "fecha" => "2016"
                        "volumen" => "23"
                        "paginaInicial" => "1355"
                        "paginaFinal" => "1364"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27592628"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparing a novel equation for calculating low&#8208;density lipoprotein cholesterol with the Friedewald equation&#58; A VOYAGER analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Palmer"
                            1 => "P&#46; Barter"
                            2 => "P&#46; Lundman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clinbiochem.2018.10.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinical Biochemistry&#46;"
                        "fecha" => "2019"
                        "volumen" => "64"
                        "paginaInicial" => "24"
                        "paginaFinal" => "29"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30365923"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of Low&#8208;Density Lipoprotein Cholesterol Assessment by Martin&#47;Hopkins Estimation&#44; Friedewald Estimation&#44; and Preparative Ultracentrifugation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Martin"
                            1 => "R&#46; Giugliano"
                            2 => "S&#46; Murphy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamacardio.2018.1533"
                      "Revista" => array:5 [
                        "tituloSerie" => "JAMA Cardiology&#46;"
                        "fecha" => "2018"
                        "volumen" => "3"
                        "paginaInicial" => "749"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29898218"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Methods for Measurement of LDL&#8208;Cholesterol&#58; A Critical Assessment of Direct Measurement by Homogeneous Assays versus Calculation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Nauck"
                            1 => "G&#46; Warnick"
                            2 => "N&#46; Rifai"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinical Chemistry&#46;"
                        "fecha" => "2002"
                        "volumen" => "48"
                        "paginaInicial" => "236"
                        "paginaFinal" => "254"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11805004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack558998"
        "titulo" => "Agradecimentos"
        "texto" => "<p id="par0195" class="elsevierStylePara elsevierViewall">Aos participantes&#44; investigadores e t&#233;cnicos de an&#225;lises que trabalharam no projeto de investiga&#231;&#227;o do estudo e&#95;COR&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "pt"
  "url" => "/08702551/0000004000000010/v1_202110050607/S0870255121002419/v1_202110050607/pt/main.assets"
  "Apartado" => array:4 [
    "identificador" => "29261"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Artigos Originais"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08702551/0000004000000010/v1_202110050607/S0870255121002419/v1_202110050607/pt/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121002419?idApp=UINPBA00004E"
]
Informação do artigo
ISSN: 08702551
Idioma original: Português
DOI:10.1016/j.repc.2020.11.011
Dados atualizados diariamente
Ano/Mês Html Pdf Total
2024 Novembro 46 8 54
2024 Outubro 338 54 392
2024 Setembro 280 61 341
2024 Agosto 202 52 254
2024 Julho 187 44 231
2024 Junho 194 29 223
2024 Maio 176 39 215
2024 Abril 139 47 186
2024 Maro 179 45 224
2024 Fevereiro 140 24 164
2024 Janeiro 170 42 212
2023 Dezembro 153 23 176
2023 Novembro 242 56 298
2023 Outubro 227 24 251
2023 Setembro 157 31 188
2023 Agosto 174 21 195
2023 Julho 157 19 176
2023 Junho 418 37 455
2023 Maio 211 35 246
2023 Abril 141 18 159
2023 Maro 156 22 178
2023 Fevereiro 153 34 187
2023 Janeiro 113 23 136
2022 Dezembro 298 33 331
2022 Novembro 253 52 305
2022 Outubro 154 54 208
2022 Setembro 172 51 223
2022 Agosto 122 62 184
2022 Julho 116 55 171
2022 Junho 114 57 171
2022 Maio 111 49 160
2022 Abril 122 51 173
2022 Maro 96 63 159
2022 Fevereiro 99 46 145
2022 Janeiro 110 45 155
2021 Dezembro 121 51 172
2021 Novembro 262 60 322
2021 Outubro 257 111 368
2021 Setembro 92 37 129
2021 Agosto 72 51 123
Mostrar tudo

Siga este link para acessar o texto completo do artigo

Receba a nossa Newsletter

Publicar em
Revista Portuguesa de Cardiologia
A revista pertence ao Committee on Publication Ethics (COPE) www.publicationethics.org e adere aos seus princípios e procedimentos.
Idiomas
Revista Portuguesa de Cardiologia
en pt

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

Ao assinalar que é «Profissional de Saúde», declara conhecer e aceitar que a responsável pelo tratamento dos dados pessoais dos utilizadores da página de internet da Revista Portuguesa de Cardiologia (RPC), é esta entidade, com sede no Campo Grande, n.º 28, 13.º, 1700-093 Lisboa, com os telefones 217 970 685 e 217 817 630, fax 217 931 095 e com o endereço de correio eletrónico revista@spc.pt. Declaro para todos os fins, que assumo inteira responsabilidade pela veracidade e exatidão da afirmação aqui fornecida.