que se leu este artigo
array:25 [ "pii" => "S0870255121000421" "issn" => "08702551" "doi" => "10.1016/j.repc.2021.02.002" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "1697" "copyright" => "Sociedade Portuguesa de Cardiologia" "copyrightAnyo" => "2021" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Rev Port Cardiol. 2021;40:245.e1-245.e5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "en" => array:20 [ "pii" => "S2174204921000775" "issn" => "21742049" "doi" => "10.1016/j.repce.2018.09.014" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "1697" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Rev Port Cardiol. 2021;40:245.e1-245.e5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Exertional chest pain is sometimes more than just coronary atherosclerosis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "245.e1" "paginaFinal" => "245.e5" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Angina de esforço: por vezes não é apenas aterosclerose coronária" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1978 "Ancho" => 2917 "Tamanyo" => 409157 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Revaluation echocardiogram with moderate left ventricular concentric hypertrophy and preserved ejection fraction.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "G.J. Morgado, A.C. Gomes, I.R. Cruz, S. Carmona, P. Fazendas, I. João, A.I. Santos, L.R. Lopes, H. Pereira" "autores" => array:9 [ 0 => array:2 [ "nombre" => "G.J." "apellidos" => "Morgado" ] 1 => array:2 [ "nombre" => "A.C." "apellidos" => "Gomes" ] 2 => array:2 [ "nombre" => "I.R." "apellidos" => "Cruz" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Carmona" ] 4 => array:2 [ "nombre" => "P." "apellidos" => "Fazendas" ] 5 => array:2 [ "nombre" => "I." "apellidos" => "João" ] 6 => array:2 [ "nombre" => "A.I." "apellidos" => "Santos" ] 7 => array:2 [ "nombre" => "L.R." "apellidos" => "Lopes" ] 8 => array:2 [ "nombre" => "H." "apellidos" => "Pereira" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0870255121000421" "doi" => "10.1016/j.repc.2021.02.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121000421?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921000775?idApp=UINPBA00004E" "url" => "/21742049/0000004000000003/v1_202104090825/S2174204921000775/v1_202104090825/en/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S0870255120305291" "issn" => "08702551" "doi" => "10.1016/j.repc.2019.12.010" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "1677" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Rev Port Cardiol. 2021;40:247-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Image in Cardiology</span>" "titulo" => "Embolization of a left atrial appendage closure device" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "247" "paginaFinal" => "248" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Embolização de dispositivo de encerramento do apêndice auricular esquerdo" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 687 "Ancho" => 2091 "Tamanyo" => 134739 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Fluoroscopy (A) and transesophageal echocardiogram (B and C) images showing correct Amplatzer Amulet device implantation in the left atrial appendage (arrows). CX indicates circumflex artery.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alzira Nunes, Diana Pissarra, Marta Tavares Silva, Pedro Bernardo Almeida, João Carlos Silva, Maria Júlia Maciel" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Alzira" "apellidos" => "Nunes" ] 1 => array:2 [ "nombre" => "Diana" "apellidos" => "Pissarra" ] 2 => array:2 [ "nombre" => "Marta" "apellidos" => "Tavares Silva" ] 3 => array:2 [ "nombre" => "Pedro Bernardo" "apellidos" => "Almeida" ] 4 => array:2 [ "nombre" => "João Carlos" "apellidos" => "Silva" ] 5 => array:2 [ "nombre" => "Maria Júlia" "apellidos" => "Maciel" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2174204921000787" "doi" => "10.1016/j.repce.2019.12.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921000787?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255120305291?idApp=UINPBA00004E" "url" => "/08702551/0000004000000003/v1_202103231637/S0870255120305291/v1_202103231637/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S0870255121000056" "issn" => "08702551" "doi" => "10.1016/j.repc.2020.08.013" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "1685" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Rev Port Cardiol. 2021;40:229-44" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "Effectiveness of preoperative breathing exercise interventions in patients undergoing cardiac surgery: A systematic review" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "229" "paginaFinal" => "244" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Eficácia de uma intervenção baseada em exercícios respiratórios em pessoas a aguardar cirurgia cardíaca: uma revisão sistemática da literatura" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0035" "etiqueta" => "Figure 7" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr7.jpeg" "Alto" => 627 "Ancho" => 2175 "Tamanyo" => 167983 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Length of hospital stay.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Soraia Nicola Rodrigues, Helga Rafael Henriques, Maria Adriana Henriques" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Soraia Nicola" "apellidos" => "Rodrigues" ] 1 => array:2 [ "nombre" => "Helga Rafael" "apellidos" => "Henriques" ] 2 => array:2 [ "nombre" => "Maria Adriana" "apellidos" => "Henriques" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2174204921000763" "doi" => "10.1016/j.repce.2020.08.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921000763?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121000056?idApp=UINPBA00004E" "url" => "/08702551/0000004000000003/v1_202103231637/S0870255121000056/v1_202103231637/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Exertional chest pain is sometimes more than just coronary atherosclerosis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "245.e1" "paginaFinal" => "245.e5" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "G.J. Morgado, A.C. Gomes, I.R. Cruz, S. Carmona, P. Fazendas, I. João, A.I. Santos, L.R. Lopes, H. Pereira" "autores" => array:9 [ 0 => array:4 [ "nombre" => "G.J." "apellidos" => "Morgado" "email" => array:1 [ 0 => "gjmorgado@outlook.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "A.C." "apellidos" => "Gomes" ] 2 => array:2 [ "nombre" => "I.R." "apellidos" => "Cruz" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Carmona" ] 4 => array:2 [ "nombre" => "P." "apellidos" => "Fazendas" ] 5 => array:2 [ "nombre" => "I." "apellidos" => "João" ] 6 => array:2 [ "nombre" => "A.I." "apellidos" => "Santos" ] 7 => array:2 [ "nombre" => "L.R." "apellidos" => "Lopes" ] 8 => array:2 [ "nombre" => "H." "apellidos" => "Pereira" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Hospital Garcia de Orta, Almada, Portugal" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Angina de esforço: por vezes não é apenas aterosclerose coronária" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1577 "Ancho" => 1583 "Tamanyo" => 110123 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Coronary angiography with slow flow and non-obstructive disease.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Coronary artery disease (CAD) is a common cause of exertional retrosternal pain in middle aged men. In patients with non-obstructive CAD, other diagnoses, including microvascular angina (and microvascular disease in the setting of other specific cardiac diseases), should be considered.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> Microcirculatory dysfunction can be diagnosed invasively with thermodilution coronary flow reserve (CFR) and the index of microvascular resistance (IMR).<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a> CFR interrogates coronary circulation as a whole, identifying whether global flow supply is normal.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a> IMR is considered a surrogate for microvascular damage and has been shown to have predictive value for myocardial recovery in patients with acute myocardial infarction.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> When IMR and CFR evaluations are combined in patients with intermediate coronary stenosis, high IMR and low CFR are associated with the worst prognosis.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">5</span></a> Our case will present the long-term prognosis of a patient with such characteristics, with the additional finding of a systemic disease with cardiac involvement.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Case description</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 64-year-old male presented with exertional retrosternal pain. He had a past medical history of hypertension, dyslipidemia, obesity, bilateral carpal tunnel syndrome and underwent bilateral surgical release and cervical laminectomy. The resting electrocardiogram revealed an incomplete left bundle branch block, while the resting echocardiogram was completely unremarkable. He underwent a stress echocardiogram with dobutamine; at peak stress, the left ventricle developed regional wall motion abnormalities including hypokinesis of the inferior wall, associated with angina and soon followed by ventricular tachycardia, reversed with propranolol. The patient was hospitalized and underwent a coronary angiography which revealed slow flow, dominant right coronary artery with non-obstructive atherosclerosis and a left anterior descending artery (LAD) with intermediate lesions in mid and distal segments (<a class="elsevierStyleCrossRefs" href="#fig0005">Figures 1 and 2</a>). A functional evaluation revealed a non-significant fractional flow reserve of 0.86 in the LAD, but a pathological CFR of 1.8 and an IMR of 61. Given the patient's symptoms, risk factors and diagnostic tests, he was considered to have microvascular angina and was treated with antiplatelet therapy, a statin, a calcium channel blocker and a transdermal nitrate, with symptomatic relief.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Three years later he developed complete atrioventricular block and presented in the emergency department with sudden hemodynamic collapse. A dual chamber pacemaker was implanted, and he was discharged asymptomatic.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Shortly after, the patient developed progressive symmetrical tetraparesis, associated with marked muscle atrophy, hand numbness, orthostatic hypotension and dysphagia. The neurology workup led to the diagnosis of familial amyloidotic polyneuropathy (FAP), and the <span class="elsevierStyleItalic">Val30Met</span> mutation in the transthyretin (TTR) gene was detected.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The following year, he developed NYHA class II to III congestive heart failure (HF), requiring uptitration of diuretics. The repeat echocardiogram showed moderate concentric left ventricular hypertrophy, with preserved ejection fraction but an abnormal global longitudinal strain and elevated filling pressures (<a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>). He repeated the coronary angiography which excluded CAD progression. He underwent a 99mTc-DPD scintigraphy that revealed significant myocardial tracer uptake, diagnosing TTR amyloid infiltration (<a class="elsevierStyleCrossRef" href="#fig0020">Figure 4</a>). He was stabilized with medical therapy and kept under close follow-up, requiring antianginal therapy uptitration for exertional microvascular angina.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">Transthyretin FAP with the <span class="elsevierStyleItalic">Val30Met</span> mutation in the transthyretin gene affects primarily the peripheral nervous system. Still, it can be associated with clinically significant myocardial infiltration<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> in up to 15% of the patients with late onset disease.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> Cardiac presentation includes conduction block, arrhythmia and cardiac hypertrophy.</p><p id="par0035" class="elsevierStylePara elsevierViewall">In our clinical case, the patient presented with microvascular angina, a rare symptom of cardiac infiltration. The only findings from his medical history that were in keeping with the suspicion of an infiltrative disease were the bilateral carpal tunnel syndrome and the atrioventricular block.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> The echocardiographic findings suggestive of myocardial infiltration were present only when the patient developed HF, after 4 years of medical follow-up. At that time, the 99mTc-DPD scintigraphy was consistent with TTR infiltration. This technique has been shown to be specific for cardiac involvement in TTR amyloidosis, with mild or no tracer uptake in patients without cardiac involvement<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> or in patients with other types of systemic amyloidosis.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> As a consequence, 99mTc-DPD scintigraphy is recommended as a diagnostic test for TTR cardiac amyloidosis in the European guidelines.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">An alternative, well validated imaging technique for the diagnosis of cardiac amyloidosis would be cardiovascular magnetic resonance, which often reveals a pattern of global, sub-endocardial or segmental late gadolinium enhancement.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> However, this exam was contraindicated in this case, as the patient had a conventional pacemaker implanted before developing HF.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Therapeutic options are limited for patients with FAP. Liver transplantation is a treatment option that prolongs life, particularly in patients with the <span class="elsevierStyleItalic">Val30Met</span> mutation.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> Tafamidis is a TTR protein stabilizer approved for the treatment of this condition. In a recently published trial, tafamidis reduced mortality and cardiovascular hospitalization when compared with placebo, in patients with wild type TTR amyloidosis and FAP.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">An important learning point of this case is that in patients with exertional angina and microvascular disease, a specific etiology should be sought, as this may occur in the context of myocardial disease, due to vascular infiltration or adverse remodeling.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conflicts of interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres1483544" "titulo" => "Abstract" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Clinical case" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Evolution" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Discussion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1350711" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1483543" "titulo" => "Resumo" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0020" "titulo" => "Caso clínico" ] 1 => array:2 [ "identificador" => "abst0025" "titulo" => "Evolução" ] 2 => array:2 [ "identificador" => "abst0030" "titulo" => "Discussão" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1350712" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case description" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflicts of interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-11-15" "fechaAceptado" => "2018-09-10" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1350711" "palabras" => array:5 [ 0 => "Microvascular angina" 1 => "Atrioventricular block" 2 => "Amyloidosis" 3 => "Hypertrophic cardiomyopathy" 4 => "Scintigraphy" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec1350712" "palabras" => array:5 [ 0 => "Angina microvascular" 1 => "Bloqueio auriculoventricular" 2 => "Amiloidose" 3 => "Miocardiopatia hipertrófica" 4 => "Cintigrafia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Clinical case</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A 64-year-old male, with cardiovascular risk factors and previous history of bilateral carpal tunnel syndrome, presented with exertional retrosternal pain. The resting echocardiogram was unremarkable. A stress echocardiogram with dobutamine revealed hypokinesis of the inferior wall, associated with angina, followed by ventricular tachycardia. The coronary angiography revealed slow flow, a dominant right coronary artery with non-obstructive atherosclerosis and a left anterior descending artery with intermediate lesions in mid and distal segments. The invasive functional evaluation, including fractional flow reserve, thermodilution coronary flow reserve and index of microvascular resistance, led to the diagnosis of microvascular angina, treated with calcium channel blockers and transdermal nitrate, giving symptom relief.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Evolution</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Three years later he developed complete atrioventricular block and a dual chamber pacemaker was implanted. Shortly after, the patient developed progressive symmetrical tetraparesis, associated with marked muscle atrophy, hand numbness, orthostatic hypotension and dysphagia. The neurology workup led to the diagnosis of familial amyloidotic polyneuropathy, with the Val30Met mutation in the transthyretin gene. The following year he developed congestive heart failure. The echocardiogram showed moderate concentric left ventricular hypertrophy with preserved ejection fraction. A 99mTc-DPD Scintigraphy showed significant myocardial tracer uptake, leading to a diagnosis of TTR amyloid infiltration.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Discussion</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Patients with exertional angina and microvascular disease should be kept under close surveillance, as they may have systemic disease with cardiac involvement. Carpal tunnel syndrome, in the context of undiagnosed cardiac disease, should trigger suspicion of cardiac amyloidosis.</p></span>" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Clinical case" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Evolution" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Discussion" ] ] ] "pt" => array:3 [ "titulo" => "Resumo" "resumen" => "<span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Caso clínico</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Um homem de 64 anos, com fatores de risco cardiovascular e antecedentes de síndrome do canal cárpico bilateral, apresentou-se com queixas de angina de esforço. O ecocardiograma em repouso era normal. O ecocardiograma de sobrecarga com dobutamina revelou hipocinésia da parede inferior, acompanhada de angina e taquicardia ventricular autolimitada. A coronariografia revelou artérias com fluxo lento, coronária direita dominante com aterosclerose não obstrutiva e descendente anterior com lesões intermédias nos segmentos médio e distal. A avaliação invasiva do significado funcional das lesões incluiu <span class="elsevierStyleItalic">fractional flow reserve</span>, <span class="elsevierStyleItalic">coronary flow reserve</span> e <span class="elsevierStyleItalic">index of microvascular resistance</span> e resultou no diagnóstico de angina microvascular, tratada com bloqueador dos canais de cálcio e nitratos, com alívio sintomático.</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Evolução</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Três anos depois, o doente desenvolveu bloqueio auriculoventricular completo, tendo sido implantado um <span class="elsevierStyleItalic">pacemaker</span> de dupla câmara. Concomitantemente, evoluiu com tetraparésia simétrica, atrofia muscular marcada, dormência das mãos, hipotensão ortostática e disfagia. A investigação do quadro neurológico resultou no diagnóstico de Polineuropatia Amiloidótica Familiar, com mutação Val30Met no gene da transtirretina. No ano seguinte, desenvolveu insuficiência cardíaca congestiva. O ecocardiograma apresentava agora hipertrofia ventricular esquerda concêntrica, com função sistólica preservada. Realizou uma cintigrafia com 99mTc-DPD que mostrou intensidade de sinal compatível com depósito intramiocárdico de substância amiloide.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Discussão</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Os doentes com angina de esforço e doença microvascular devem manter seguimento clínico regular, uma vez que poderão ter uma doença sistémica com envolvimento cardíaco. A síndrome do canal cárpico, no contexto de doença cardíaca não esclarecida, deve levantar a suspeita de amiloidose cardíaca.</p></span>" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0020" "titulo" => "Caso clínico" ] 1 => array:2 [ "identificador" => "abst0025" "titulo" => "Evolução" ] 2 => array:2 [ "identificador" => "abst0030" "titulo" => "Discussão" ] ] ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0065" class="elsevierStylePara elsevierViewall">The following are the supplementary material to this article:<elsevierMultimedia ident="upi0005"></elsevierMultimedia><elsevierMultimedia ident="upi0010"></elsevierMultimedia></p>" "etiqueta" => "Appendix A" "titulo" => "Supplementary material" "identificador" => "sec0030" ] ] ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1577 "Ancho" => 1583 "Tamanyo" => 110123 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Coronary angiography with slow flow and non-obstructive disease.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1578 "Ancho" => 1583 "Tamanyo" => 115832 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Coronary angiography with slow flow and non-obstructive disease.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1978 "Ancho" => 2917 "Tamanyo" => 409157 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Revaluation echocardiogram with moderate left ventricular concentric hypertrophy and preserved ejection fraction.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1878 "Ancho" => 2917 "Tamanyo" => 297013 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">99mTc-DPD scintigraphy revealed significant myocardial tracer uptake, diagnosing TTR amyloid infiltration.</p>" ] ] 4 => array:5 [ "identificador" => "upi0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:3 [ "fichero" => "mmc1.mp4" "ficheroTamanyo" => 1127874 "Video" => array:2 [ "mp4" => array:5 [ "fichero" => "mmc1.m4v" "poster" => "mmc1.jpg" "tiempo" => 0 "alto" => 0 "ancho" => 0 ] "flv" => array:5 [ "fichero" => "mmc1.flv" "poster" => "mmc1.jpg" "tiempo" => 0 "alto" => 0 "ancho" => 0 ] ] ] ] 5 => array:5 [ "identificador" => "upi0010" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:3 [ "fichero" => "mmc2.mp4" "ficheroTamanyo" => 1295087 "Video" => array:2 [ "flv" => array:5 [ "fichero" => "mmc2.flv" "poster" => "mmc2.jpg" "tiempo" => 0 "alto" => 0 "ancho" => 0 ] "mp4" => array:5 [ "fichero" => "mmc2.m4v" "poster" => "mmc2.jpg" "tiempo" => 0 "alto" => 0 "ancho" => 0 ] ] ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0080" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2013 ESC guidelines on the management of stable coronary artery disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Montalescot" 1 => "U. Sechtem" 2 => "S. Achenbach" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Heart J" "fecha" => "2013" "volumen" => "34" "paginaInicial" => "2949" "paginaFinal" => "3003" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0085" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disturbed coronary hemodynamics in vessels with intermediate stenoses evaluated with fractional flow reserve a combined analysis of epicardial and microcirculatory involvement in ischemic heart disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Echavarria-Pinto" 1 => "J. Escaned" 2 => "E. Macías" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/CIRCULATIONAHA.112.001345" "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2013" "volumen" => "128" "paginaInicial" => "2557" "paginaFinal" => "2566" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24141255" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0090" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "State of the art: pressure wire and coronary functional assessment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Echavarría-Pinto" 1 => "C. Collet" 2 => "J. Escaned" 3 => "J.J. Piek" 4 => "P. Serruys" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4244/EIJ-D-17-00503" "Revista" => array:6 [ "tituloSerie" => "EuroIntervention" "fecha" => "2017" "volumen" => "13" "paginaInicial" => "666" "paginaFinal" => "679" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28844029" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0095" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictive value of the index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "W.F. Fearon" 1 => "M. Shah" 2 => "M. Ng" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2007.08.062" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2008" "volumen" => "51" "paginaInicial" => "560" "paginaFinal" => "565" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18237685" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0100" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Coronary flow reserve and microcirculatory resistance in patients with intermediate coronary stenosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.M. Lee" 1 => "J.H. Jung" 2 => "D. Hwang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2015.12.053" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2016" "volumen" => "67" "paginaInicial" => "1158" "paginaFinal" => "1169" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26965536" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0105" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transthyretin (TTR) cardiac amyloidosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F.L. Ruberg" 1 => "J.L. Berk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/CIRCULATIONAHA.111.078915" "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2012" "volumen" => "126" "paginaInicial" => "1286" "paginaFinal" => "1300" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22949539" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0110" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Red-flag symptom clusters in transthyretin familial amyloid polyneuropathy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "I. Conceição" 1 => "A. González-Duarte" 2 => "L. Obici" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jns.12153" "Revista" => array:6 [ "tituloSerie" => "J Peripher Nerv Syst" "fecha" => "2016" "volumen" => "21" "paginaInicial" => "5" "paginaFinal" => "9" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26663427" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0115" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic work-up in cardiomyopathies: bridging the gap between clinical phenotypes and final diagnosis. A position statement from the ESC Working Group on Myocardial and Pericardial Diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C. Rapezzi" 1 => "E. Arbustini" 2 => "A.L.P. Caforio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehs397" "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2013" "volumen" => "34" "paginaInicial" => "1448" "paginaFinal" => "1458" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23211230" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0120" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of 99mTc-DPD scintigraphy in diagnosis and prognosis of hereditary transthyretin-related cardiac amyloidosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C. Rapezzi" 1 => "C.C. Quarta" 2 => "P.L. Guidalotti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jcmg.2011.03.016" "Revista" => array:6 [ "tituloSerie" => "JACC Cardiovasc Imaging" "fecha" => "2011" "volumen" => "4" "paginaInicial" => "659" "paginaFinal" => "670" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21679902" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0125" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Usefulness and limitations of 99mTc-3, 3-diphosphono-1, 2-propanodicarboxylic acid scintigraphy in the aetiological diagnosis of amyloidotic cardiomyopathy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C. Rapezzi" 1 => "C.C. Quarta" 2 => "P.L. Guidalotti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00259-010-1642-7" "Revista" => array:6 [ "tituloSerie" => "Eur J Nucl Med Mol Imaging" "fecha" => "2011" "volumen" => "38" "paginaInicial" => "470" "paginaFinal" => "478" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21069320" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0130" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2014 ESC guidelines on diagnosis and management of hypertrophic cardiomyopathy: the task force for the diagnosis and management of hypertrophic cardiomyopathy of the European Society of Cardiology (ESC)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P.M. Elliott" 1 => "A. Anastasakis" 2 => "M.A. Borger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehu284" "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2014" "volumen" => "35" "paginaInicial" => "2733" "paginaFinal" => "2779" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25173338" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0135" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of cardiac magnetic resonance imaging in the detection of cardiac amyloidosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "I.S. Syed" 1 => "J.F. Glockner" 2 => "D. Feng" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jcmg.2009.09.023" "Revista" => array:6 [ "tituloSerie" => "JACC Cardiovasc Imaging" "fecha" => "2010" "volumen" => "3" "paginaInicial" => "155" "paginaFinal" => "164" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20159642" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0140" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Liver transplantation and transthyretin amyloidosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.D. Benson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/mus.23521" "Revista" => array:6 [ "tituloSerie" => "Muscle Nerve" "fecha" => "2013" "volumen" => "47" "paginaInicial" => "157" "paginaFinal" => "162" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23169427" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0145" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.S. Maurer" 1 => "J.H. Schwartz" 2 => "B. Gundapaneni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa1915928" "Revista" => array:4 [ "tituloSerie" => "N Engl J Med" "fecha" => "2018" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32222134" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0923753419392075" "estado" => "S300" "issn" => "09237534" ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0150" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Coronary microvascular dysfunction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.G. Camici" 1 => "F. Crea" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMra061889" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2007" "volumen" => "356" "paginaInicial" => "830" "paginaFinal" => "840" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17314342" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/08702551/0000004000000003/v1_202103231637/S0870255121000421/v1_202103231637/en/main.assets" "Apartado" => array:4 [ "identificador" => "75833" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Caso Clínico" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/08702551/0000004000000003/v1_202103231637/S0870255121000421/v1_202103231637/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121000421?idApp=UINPBA00004E" ]
Ano/Mês | Html | Total | |
---|---|---|---|
2024 Novembro | 6 | 8 | 14 |
2024 Outubro | 62 | 44 | 106 |
2024 Setembro | 56 | 27 | 83 |
2024 Agosto | 52 | 39 | 91 |
2024 Julho | 45 | 46 | 91 |
2024 Junho | 45 | 38 | 83 |
2024 Maio | 49 | 29 | 78 |
2024 Abril | 47 | 34 | 81 |
2024 Maro | 40 | 28 | 68 |
2024 Fevereiro | 37 | 30 | 67 |
2024 Janeiro | 48 | 32 | 80 |
2023 Dezembro | 50 | 19 | 69 |
2023 Novembro | 58 | 46 | 104 |
2023 Outubro | 40 | 15 | 55 |
2023 Setembro | 32 | 20 | 52 |
2023 Agosto | 20 | 20 | 40 |
2023 Julho | 46 | 11 | 57 |
2023 Junho | 46 | 14 | 60 |
2023 Maio | 40 | 28 | 68 |
2023 Abril | 26 | 6 | 32 |
2023 Maro | 39 | 27 | 66 |
2023 Fevereiro | 34 | 23 | 57 |
2023 Janeiro | 25 | 15 | 40 |
2022 Dezembro | 47 | 23 | 70 |
2022 Novembro | 49 | 34 | 83 |
2022 Outubro | 37 | 26 | 63 |
2022 Setembro | 38 | 50 | 88 |
2022 Agosto | 27 | 42 | 69 |
2022 Julho | 42 | 43 | 85 |
2022 Junho | 37 | 37 | 74 |
2022 Maio | 40 | 41 | 81 |
2022 Abril | 40 | 57 | 97 |
2022 Maro | 52 | 49 | 101 |
2022 Fevereiro | 30 | 48 | 78 |
2022 Janeiro | 34 | 28 | 62 |
2021 Dezembro | 36 | 40 | 76 |
2021 Novembro | 42 | 45 | 87 |
2021 Outubro | 53 | 60 | 113 |
2021 Setembro | 33 | 35 | 68 |
2021 Agosto | 55 | 54 | 109 |
2021 Julho | 28 | 38 | 66 |
2021 Junho | 28 | 54 | 82 |
2021 Maio | 36 | 53 | 89 |
2021 Abril | 179 | 100 | 279 |
2021 Maro | 115 | 87 | 202 |