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Image in Cardiology
Functional assessment of coronary disease using workstation-based computed tomography-derived fractional flow reserve
Avaliação funcional de doença coronária utilizando FFR derivado de TC
Nuno Dias Ferreira
Autor para correspondência
ferreira.nmd@gmail.com

Corresponding author.
, Ricardo Ladeiras-Lopes, Gustavo Pires de Morais, Vasco Gama, Pedro Braga
Serviço de Cardiologia, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal
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    "titulo" => "Functional assessment of coronary disease using workstation-based computed tomography-derived fractional flow reserve"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 55-year-old man presented to our outpatient clinic reporting a six-month history of exertional dyspnea and intermittent atypical chest pain&#46; His medical history included essential hypertension&#46; The baseline electrocardiogram and echocardiogram were normal&#46; The patient underwent treadmill exercise stress testing under the Bruce protocol&#46; During stage 3&#44; the patient developed 1&#46;5-mm horizontal ST depression in V3-V6 and the inferior leads&#46; The test was interrupted at 9 min due to fatigue&#44; with no chest pain&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Due to intermediate risk findings on the treadmill test&#44; coronary computed tomography angiography &#40;CCTA&#41; was requested for further assessment&#46; The coronary calcium score was 105&#46;2 Agatston units and an intermediate stenosis was identified in the proximal left anterior descending artery &#40;LAD&#41; due to non-calcified plaque &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>A and D&#44; arrow&#41;&#46; Because the physiologic significance of the lesion was unclear&#44; computed tomography-derived fractional flow reserve &#40;CT-FFR&#41; was determined using a workstation-based software prototype &#40;cFFR&#44; Siemens AG Healthcare&#44; Forchheim&#44; Germany&#41;&#46; The value of CT-FFR just beyond the proximal LAD stenosis was 0&#46;75 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#46; The patient was referred for invasive coronary angiography &#40;ICA&#41; which confirmed a 75&#37; stenosis in the proximal LAD &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>B and Supplementary Video S1&#41;&#46; Invasive FFR assessed in the LAD showed a similar result &#40;0&#46;76&#41; to that observed on CCTA &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figures 3</a>A and 3C&#41;&#46; The patient successfully underwent percutaneous coronary intervention with a drug-eluting stent &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Figure 4</a>&#41; and was asymptomatic after the procedure&#46; This case illustrates the value of CT-FFR as a gatekeeper prior to ICA&#44; to appropriately select patients and vessels for revascularization&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0015" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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