que se leu este artigo
array:26 [ "pii" => "S0870255117307837" "issn" => "08702551" "doi" => "10.1016/j.repc.2016.08.015" "estado" => "S300" "fechaPublicacion" => "2017-11-01" "aid" => "1101" "copyright" => "Sociedade Portuguesa de Cardiologia" "copyrightAnyo" => "2017" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Rev Port Cardiol. 2017;36:871.e1-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1911 "formatos" => array:3 [ "EPUB" => 150 "HTML" => 1396 "PDF" => 365 ] ] "Traduccion" => array:1 [ "en" => array:19 [ "pii" => "S217420491730329X" "issn" => "21742049" "doi" => "10.1016/j.repce.2017.11.008" "estado" => "S300" "fechaPublicacion" => "2017-11-01" "aid" => "1101" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Rev Port Cardiol. 2017;36:871.e1-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1248 "formatos" => array:3 [ "EPUB" => 119 "HTML" => 860 "PDF" => 269 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Heart transplantation for Chagas cardiomyopathy" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "871.e1" "paginaFinal" => "871.e4" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Transplante cardíaco na miocardiopatia de Chagas" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 703 "Ancho" => 1667 "Tamanyo" => 153714 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Trypanosoma cruzi</span> intracytoplasmic amastigotes (arrows). Heart muscle, hematoxylin-eosin stain, 1000×.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ana Rita Ramalho, David Prieto, Fátima Franco, Manuel J. Antunes" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Ana Rita" "apellidos" => "Ramalho" ] 1 => array:2 [ "nombre" => "David" "apellidos" => "Prieto" ] 2 => array:2 [ "nombre" => "Fátima" "apellidos" => "Franco" ] 3 => array:2 [ "nombre" => "Manuel J." 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optical coherence tomography (OCT) demonstrating a heterogeneous hypointensive neointima with a bright superficial layer (arrow) and presence of macrophage infiltration and microvessels (asterisk) into the neointima in the first-generation DES (B and b), and a homogeneous hyperintensive neointima in the second-generation DES (C and c); OCT post-stent (D) showing good expansion and apposition of the bioresorbable scaffold.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Daniele Gemma, Santiago Jimenez Valero, Raúl Moreno Gómez, Francisco Javier Irazusta Córdoba, Pablo Merás Colunga, José Luis López-Sendón" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Daniele" "apellidos" => "Gemma" ] 1 => array:2 [ "nombre" => "Santiago Jimenez" "apellidos" => "Valero" ] 2 => array:2 [ "nombre" => "Raúl Moreno" "apellidos" => "Gómez" ] 3 => array:2 [ "nombre" => "Francisco Javier Irazusta" "apellidos" => "Córdoba" ] 4 => array:2 [ "nombre" => "Pablo Merás" "apellidos" => "Colunga" ] 5 => array:2 [ "nombre" => "José Luis" "apellidos" => "López-Sendón" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2174204917303252" "doi" => "10.1016/j.repce.2017.11.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204917303252?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255117307849?idApp=UINPBA00004E" "url" => "/08702551/0000003600000011/v2_201801180628/S0870255117307849/v2_201801180628/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S0870255117307825" "issn" => "08702551" "doi" => "10.1016/j.repc.2017.03.009" "estado" => "S300" "fechaPublicacion" => "2017-11-01" "aid" => "1100" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Rev Port Cardiol. 2017;36:869.e1-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2295 "formatos" => array:3 [ "EPUB" => 167 "HTML" => 1776 "PDF" => 352 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "A rare variant of intracardiac total anomalous pulmonary venous connection" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "869.e1" "paginaFinal" => "869.e4" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Uma variante rara da conexão venosa pulmonar anómala total intracardíaca" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1649 "Ancho" => 2333 "Tamanyo" => 393823 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Subcostal transthoracic echocardiographic views showing the confluence of the pulmonary veins opening into the right atrium and an atrial septal defect with right-to-left shunt. 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Antunes" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Ana Rita" "apellidos" => "Ramalho" "email" => array:1 [ 0 => "anarita_ramalho@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "David" "apellidos" => "Prieto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Pedro" "apellidos" => "Antunes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Fátima" "apellidos" => "Franco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Manuel J." "apellidos" => "Antunes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Coimbra Hospital and University Center, Cardiology Department, Coimbra, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Coimbra Hospital and University Center, Cardiothoracic Surgery Department, Coimbra, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Transplante cardíaco na miocardiopatia de Chagas" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 703 "Ancho" => 1667 "Tamanyo" => 153714 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Trypanosoma cruzi</span> intracytoplasmic amastigotes (arrows). Heart muscle, hematoxylin-eosin stain, 1000×.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Chagas disease is emerging as a health care concern in non-endemic countries due to increasing emigration of Latin Americans. Chagas cardiomyopathy (CCM) is a severe complication of the disease and an established indication for heart transplantation (HTx). Because this condition is frequently neglected outside Latin America as a cause of chronic heart failure (CHF), awareness needs to be raised among health care professionals in non-endemic countries.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The present article reports the first HTx for CCM in Portugal and its outcome during the first year of follow-up, and reviews current practice of graft management in Chagas heart transplant recipients.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0015" class="elsevierStylePara elsevierViewall">A 56-year-old female Brazilian immigrant in Portugal with end-stage CCM underwent HTx. She had been treated with nifurtimox at some point and had an implanted cardioverter-defibrillator (ICD) for secondary prevention. In the 12 months before HTx, she had multiple hospital admissions for CHF decompensation and had episodes of syncope due to ventricular tachycardia, without delivery of shocks by the ICD. In January 2015, she was admitted to a heart failure care unit in New York Heart Association (NYHA) functional class IV, with left ventricular ejection fraction (LVEF) of 19%, peak oxygen consumption of 12 ml/kg/min and cardiac index of 1.15 l/min/m<span class="elsevierStyleSup">2</span>. She also had hyponatremia (131 mmol/l) and elevated brain natriuretic peptide (1112 pg/ml). She was under maximum tolerated doses of beta-blockers, angiotensin-converting enzyme inhibitors, mineralocorticoid receptor antagonists and digoxin. At this stage, the local heart team decided to include her on the HTx list and she received a graft from a 35-year-old male donor on February 7, 2015.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Postoperative recovery was uneventful. The immunosuppressive scheme included prednisone, tacrolimus and mycophenolate mofetil (MMF) in the usual dosage. There was no evidence of early rejection or <span class="elsevierStyleItalic">Trypanosoma cruzi</span> infection reactivation and she was discharged 12 days after surgery. Microscopic examination of the explanted heart revealed intracytoplasmic amastigotes (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>), patchy fibrosis and an apical aneurysm.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Twelve months after HTx the patient is in NYHA class I and has resumed a normal life, with good graft function. Monitoring for <span class="elsevierStyleItalic">T. cruzi</span> reactivation included clinical assessment for signs or symptoms of cardiac, neurological or cutaneous involvement, electrocardiography to detect arrhythmias or conduction disturbances, echocardiography to detect left ventricular dysfunction, whole blood testing by polymerase chain reaction (PCR) for <span class="elsevierStyleItalic">T. cruzi</span> reactivation (performed every two months), and endomyocardial biopsy (EMB) to screen for amastigotes, as suggested.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">1</span></a> No episodes of <span class="elsevierStyleItalic">T. cruzi</span> reactivation occurred or were suspected. Prophylactic antiparasitic therapy was not used. She has had 10 EMBs, as per protocol, which showed no evidence of graft rejection. There have been no opportunistic infections or evidence of neoplasm.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">Chagas disease, caused by the protozoan hemoflagellate <span class="elsevierStyleItalic">T. cruzi</span>, develops in three stages: acute, usually asymptomatic (although fever and chills may occur); indeterminate, with persistent parasitemia but no organ involvement; and chronic (after 10-30 years), characterized by cardiac and/or digestive tract involvement.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Cardiomyopathy results from slowly progressive chronic myocarditis, associated with focal hypoperfusion due to abnormalities of coronary microvasculature, leading to dilatation of all four chambers, formation of typical apical aneurysms and damage to conductive tissue. CHF associated with CCM carries higher mortality than other more frequent causes of cardiac failure<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">3</span></a> and is the most frequent cause of chronic systolic dysfunction in endemic countries.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">4</span></a> Most patients (two-thirds) die from sudden cardiac death, refractory CHF (25-30%) or thromboembolism (10-15%).<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Antiparasitic therapy (with nifurtimox or benznidazole) may be curative in the acute stage of the disease<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">6</span></a>; during the indeterminate stages it may prevent progression to chronic aggressive forms, as well as congenital transmission.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">7</span></a> In the chronic stage, benznidazole effectively reduces parasite detection but has no impact on clinical progression in patients with established CCM.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">HTx is the only approach to symptomatic CCM that appears to have benefit, with better outcomes compared to other more frequent indications for the procedure.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a> NYHA class IV, LVEF <30%, inotropic dependence, digoxin use or no beta-blocker use, hyponatremia, peak oxygen consumption <10 ml/kg/min and need for ≥4 appropriate ICD shocks within 30 days are all predictors of one-year survival of less than 30%, and have been proposed as selection criteria for HTx.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">10</span></a> In the present case, NYHA class, LVEF, hyponatremia and digoxin therapy contributed to our patient's poor prognosis and were taken into account in the decision to perform HTx as the best therapeutic approach, which we believe may have been the first in Portugal.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Survival in the first month after HTx for CCM has been reported to be as high as 83%, without complicating rejection or infection in 53% and 57% of cases, respectively.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">11</span></a> Parasitemia may occur in up to 29% of patients, while <span class="elsevierStyleItalic">T. cruzi</span> reactivation has rarely been observed.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a> None of these situations occurred in our patient in early follow-up.</p><p id="par0055" class="elsevierStylePara elsevierViewall">There is no consensus as to the ideal immunosuppressive regimen for Chagas HTx recipients, and conventional schemes using triple combinations have been used according to local protocols, as in our case. Overall, there are no major differences in rejection rate between Chagas and non-Chagas HTx recipients,<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">10</span></a> and one can speculate that conventional schemes of immunosuppressors for this special cohort of patients may be quite acceptable. Opportunistic infections seem to occur less often in Chagas transplant recipients than in other HTx recipients,<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">13</span></a> while the incidence of malignancies in HTx recipients is similar.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">13,14</span></a> In our case, serial EMBs showed no evidence of rejection, and no opportunistic infections or signs of malignancy were detected during the first year of follow-up.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Recurrence of Chagas disease is a major concern after HTx because of the risk of allograft dysfunction, and was once considered a contraindication for HTx. Since the work of Bocchi et al., published in 1996,<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">11</span></a> the success and benefit of HTx for CCM patients have become clear, and today it is a frequent indication for HTx worldwide, the leading indication in some endemic countries. Immunosuppressive therapy increases the risk of <span class="elsevierStyleItalic">T. cruzi</span> reactivation, particularly steroids used in high-dose pulses for graft rejection.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">14–16</span></a> Furthermore, MMF appears to lead to higher frequency and earlier occurrence of reactivation episodes compared to azathioprine-based protocols.<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10,12,13,17</span></a> Cyclosporine seems to play no role in reactivation of <span class="elsevierStyleItalic">T. cruzi</span> infection.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">10</span></a> Although it has been suggested that the combination of the more potent immunosuppressive agents, tacrolimus and MMF, is associated with higher rate of <span class="elsevierStyleItalic">T. cruzi</span> reactivation,<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a> our experience using this strategy in this patient has been good so far.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Nevertheless, <span class="elsevierStyleItalic">T. cruzi</span> reactivation is easily treated using benznidazole (5 mg/kg/day for two months) or allopurinol (600-900 mg/day for two months), and the overall prognosis is good (reported mortality of 0.7%<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a>). Screening for reactivation should be based on PCR of whole blood samples, which is sufficiently sensitive to detect reactivation before complications can develop, enabling timely treatment.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Finally, medium- and long-term survival after HTx in Chagas patients is surprisingly good (with survival rates at one, two, six and 10 years as high as 83%, 76%, 62% and 46%, respectively<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">10</span></a>) and some series indicate a greater benefit of the procedure compared to non-Chagas HTx recipients.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusion</span><p id="par0075" class="elsevierStylePara elsevierViewall">CCM is emerging as a cause of CHF and arrhythmic complications outside Latin America. Health care workers should be aware of this disease and have a high degree of suspicion when dealing with Latin American immigrants presenting with a cardiomyopathy of unknown cause. For those with end-stage HF of Chagas etiology, antiparasitic drugs can no longer affect their poor outcome. HTx should be regarded as a viable and beneficial therapeutic option for these patients, with a greater survival benefit compared to non-Chagas HTx recipients. The feared <span class="elsevierStyleItalic">T. cruzi</span> infection reactivation in graft recipients is no longer a contraindication for HTx, is easily treated with antiparasitic drugs, and portends a very low mortality rate.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres971728" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec942356" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres971729" "titulo" => "Resumo" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec942355" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conclusion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflicts of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-06-08" "fechaAceptado" => "2016-08-01" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec942356" "palabras" => array:4 [ 0 => "Chagas disease" 1 => "Chagas cardiomyopathy" 2 => "Heart transplantation" 3 => "<span class="elsevierStyleItalic">Trypanosoma cruzi</span> infection reactivation" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec942355" "palabras" => array:4 [ 0 => "Doença de Chagas" 1 => "Miocardiopatia de Chagas" 2 => "Transplante cardíaco" 3 => "Reativação de infeção por <span class="elsevierStyleItalic">Trypanosoma cruzi</span>" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chagas disease is an endemic disease in Latin America that is increasingly found in non-endemic areas all over the world due to the flow of migrants from Central and South America. We present the case of a Brazilian immigrant in Portugal who underwent orthotopic heart transplantation for end-stage Chagas cardiomyopathy. Immunosuppressive therapy included prednisone, mycophenolate mofetil and tacrolimus. Twelve months after the procedure she is asymptomatic, with good graft function, and with no evidence of complications such as graft rejection, opportunistic infections, neoplasms or reactivation of <span class="elsevierStyleItalic">Trypanosoma cruzi</span> infection. By reporting the first case in Portugal of heart transplantation for Chagas cardiomyopathy, we aim to increase awareness of Chagas disease as an emerging global problem and of Chagas cardiomyopathy as a serious complication for which heart transplantation is a valuable therapeutic option.</p></span>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A doença de Chagas é uma doença endêmica da América Latina cada vez mais reconhecida em áreas não endêmicas por todo o mundo, devido ao crescente fluxo migratório proveniente da América Central e do Sul. Apresentamos o caso de uma mulher de nacionalidade brasileira imigrante em Portugal submetida a transplante cardíaco por miocardiopatia de Chagas. A terapêutica imunossupressora a que foi submetida incluiu prednisona, micofenolato mofetil e tacrolimus. Doze meses após o procedimento a doente está assintomática, apresenta boa função do enxerto e sem evidência de complicações no seguimento, como rejeição, infeções oportunistas, neoplasias ou reativação da infeção por <span class="elsevierStyleItalic">Trypanosoma cruzi</span>. Ao reportar o primeiro caso em Portugal de transplante cardíaco por miocardiopatia de Chagas pretendemos alertar para o reconhecimento da doença de Chagas como um problema emergente em nível global e da miocardiopatia de Chagas como uma grave complicação da doença, para a qual o transplante cardíaco é uma válida opção terapêutica.</p></span>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 703 "Ancho" => 1667 "Tamanyo" => 153714 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Trypanosoma cruzi</span> intracytoplasmic amastigotes (arrows). Heart muscle, hematoxylin-eosin stain, 1000×.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib0090" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chagas disease in solid organ and heart transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Kransdorf" 1 => "P. Zakowski" 2 => "J. 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Teno" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/1054-8807(94)90011-6" "Revista" => array:6 [ "tituloSerie" => "Cardiovasc Pathol" "fecha" => "1994" "volumen" => "3" "paginaInicial" => "257" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25991019" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0170" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors for Chagas’ disease reactivation after heart transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.V. Campos" 1 => "T.M.V. Strabelli" 2 => "V. 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2023 Novembro | 43 | 38 | 81 |
2023 Outubro | 31 | 23 | 54 |
2023 Setembro | 40 | 20 | 60 |
2023 Agosto | 32 | 14 | 46 |
2023 Julho | 38 | 10 | 48 |
2023 Junho | 38 | 10 | 48 |
2023 Maio | 49 | 22 | 71 |
2023 Abril | 46 | 5 | 51 |
2023 Maro | 62 | 23 | 85 |
2023 Fevereiro | 30 | 27 | 57 |
2023 Janeiro | 21 | 22 | 43 |
2022 Dezembro | 47 | 23 | 70 |
2022 Novembro | 80 | 30 | 110 |
2022 Outubro | 57 | 29 | 86 |
2022 Setembro | 34 | 35 | 69 |
2022 Agosto | 43 | 35 | 78 |
2022 Julho | 47 | 42 | 89 |
2022 Junho | 33 | 29 | 62 |
2022 Maio | 30 | 41 | 71 |
2022 Abril | 40 | 29 | 69 |
2022 Maro | 38 | 36 | 74 |
2022 Fevereiro | 32 | 42 | 74 |
2022 Janeiro | 39 | 26 | 65 |
2021 Dezembro | 27 | 33 | 60 |
2021 Novembro | 35 | 36 | 71 |
2021 Outubro | 45 | 50 | 95 |
2021 Setembro | 30 | 26 | 56 |
2021 Agosto | 30 | 38 | 68 |
2021 Julho | 25 | 17 | 42 |
2021 Junho | 27 | 18 | 45 |
2021 Maio | 47 | 38 | 85 |
2021 Abril | 77 | 38 | 115 |
2021 Maro | 85 | 22 | 107 |
2021 Fevereiro | 46 | 17 | 63 |
2021 Janeiro | 40 | 17 | 57 |
2020 Dezembro | 29 | 20 | 49 |
2020 Novembro | 43 | 16 | 59 |
2020 Outubro | 21 | 17 | 38 |
2020 Setembro | 49 | 16 | 65 |
2020 Agosto | 26 | 10 | 36 |
2020 Julho | 62 | 21 | 83 |
2020 Junho | 48 | 12 | 60 |
2020 Maio | 26 | 3 | 29 |
2020 Abril | 48 | 14 | 62 |
2020 Maro | 36 | 9 | 45 |
2020 Fevereiro | 100 | 14 | 114 |
2020 Janeiro | 28 | 10 | 38 |
2019 Dezembro | 42 | 15 | 57 |
2019 Novembro | 32 | 9 | 41 |
2019 Outubro | 32 | 5 | 37 |
2019 Setembro | 45 | 5 | 50 |
2019 Agosto | 31 | 16 | 47 |
2019 Julho | 49 | 8 | 57 |
2019 Junho | 80 | 15 | 95 |
2019 Maio | 126 | 9 | 135 |
2019 Abril | 46 | 9 | 55 |
2019 Maro | 67 | 15 | 82 |
2019 Fevereiro | 77 | 14 | 91 |
2019 Janeiro | 41 | 5 | 46 |
2018 Dezembro | 40 | 14 | 54 |
2018 Novembro | 108 | 7 | 115 |
2018 Outubro | 129 | 30 | 159 |
2018 Setembro | 34 | 11 | 45 |
2018 Agosto | 25 | 10 | 35 |
2018 Julho | 9 | 6 | 15 |
2018 Junho | 29 | 5 | 34 |
2018 Maio | 29 | 8 | 37 |
2018 Abril | 29 | 10 | 39 |
2018 Maro | 54 | 19 | 73 |
2018 Fevereiro | 37 | 9 | 46 |
2018 Janeiro | 36 | 17 | 53 |
2017 Dezembro | 51 | 57 | 108 |
2017 Novembro | 9 | 17 | 26 |