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showed multiple aortic valve vegetations &#40;some prolapsing into the left ventricular outflow tract&#41;&#44; mild aortic regurgitation and a large saccular bulge originating from the anterior mitral valve leaflet and protruding into the left atrium with severe mitral regurgitation &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#59; left ventricular systolic function was normal&#46; With transesophageal echocardiography &#40;TEE&#41; it became clear that the saccular bulging on the mitral valve was an anterior mitral valve leaflet aneurysm with two rupture sites &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#46; Color flow Doppler showed two regurgitant jets&#58; one through the coaptation margin of the mitral valve leaflets and the other across the perforated aneurysm &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>&#41;&#46; There was no evidence of either aortic ring abscess formation or extension along the mitral-aortic intervalvular fibrosa&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Antibiotic therapy was started with vancomycin plus gentamicin &#40;due to penicillin allergy&#41; for infective endocarditis &#40;IE&#41;&#46; After clinical stabilization&#44; he was referred for urgent cardiac surgery&#46; Given his clinical stability&#44; surgery was delayed for four more days of antibiotic therapy&#46; The patient died suddenly one day before scheduled surgical intervention&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">Mitral valve aneurysms &#40;MVAs&#41; are uncommon but potentially serious complications&#44; occurring most frequently in association with aortic valve endocarditis&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">1&#8211;4</span></a> The first case was reported by Morand in 1729&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">5</span></a> In 1970&#44; Gonzalez-Lavin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">6</span></a> reported secondary involvement of the mitral valve with leaflet aneurysm in two &#40;3&#46;4&#37;&#41; patients out of 58 who underwent aortic valve surgery for IE&#46; Similar results were reported in 1992 by Karalis et al&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">7</span></a> in a group of 55 patients with aortic valve endocarditis evaluated by TEE&#46; More recent reports present a very low incidence&#44; around 0&#46;2-0&#46;29&#37; of patients who undergo TEE&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">2&#44;4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Although most frequently associated with IE&#44; other non-infectious etiologies have been reported including congenital cardiac structural defects&#44; extreme forms of mitral valve prolapse&#44; Libman-Sacks endocarditis and connective tissue disorders such as Marfan syndrome&#44; Ehlers-Danlos syndrome&#44; pseudoxanthoma elasticum and osteogenesis imperfecta&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">4&#44;9&#8211;13</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Because MVA is rare in the absence of IE&#44; an infectious etiology will be at least partly responsible for leaflet degeneration&#46; Proposed mechanisms for the development of MVA in the setting of aortic valve endocarditis include direct extension of the infection through the mitral-aortic intervalvular fibrosa to the anterior mitral valve leaflet with abscess formation and subsequent drainage&#44; seeding of the anterior mitral valve leaflet by the aortic regurgitant jet &#40;&#8216;jet lesion&#8217;&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">1&#44;3&#44;8&#44;14&#8211;16</span></a> or through direct contact with an aortic vegetation prolapsing into the left ventricular outflow tract &#40;&#8216;kissing vegetation&#8217;&#41;&#44; especially if the vegetation exceeds 6 mm in size&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">17</span></a> These processes are thought to cause localized inflammation&#44; weakness&#44; dissection&#44; and subsequent expansion of the valvular tissue&#44; which in turn protrudes toward the left atrium due to ventricular systolic pressure&#44; leading to aneurysm formation&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">2&#44;18&#8211;21</span></a> In our case&#44; because aortic regurgitation was only mild&#44; we believe that the most likely mechanism for aneurysm development was previous abscess formation &#40;secondary to direct extension of infection from the aortic valve or a prolapsing aortic vegetation&#41; followed by rupture and drainage&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The diagnosis may be suspected by TTE but TEE is more sensitive for detecting MVA&#44; leaflet rupture and mitral regurgitation&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">2&#44;4&#44;22&#8211;25</span></a> Recently&#44; a few reports have highlighted the role of real-time three-dimensional echocardiography to better define the anatomical features of MVA preoperatively&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">16&#44;26&#8211;28</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Echocardiography shows MVA as a localized saccular bulge of the mitral valve leaflet toward the left atrium communicating with the left ventricle&#44; expanding in systole and collapsing in diastole&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">2</span></a> Diastolic expansion can occur in cases of MVA rupture or severe aortic regurgitation&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">28</span></a> These lesions can vary from a few mm to 4 cm in diameter and may contain thrombi&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">8</span></a> The anterior leaflet is much more commonly involved than the posterior leaflet&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">2&#8211;4</span></a> The diagnosis of perforation is based on the presence of a high-velocity regurgitant jet traversing the aneurysm in systole and further supported by demonstration of an interrupted segment of the aneurysm by two-dimensional examination&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">4&#44;29</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">MVA must be differentiated from various abnormalities with similar echocardiographic appearance including severe mitral valve prolapse&#44; diverticulum of the mitral valve&#44; large valvular vegetation&#44; flail valve leaflet&#44; blood cyst of the papillary muscle&#44; cystic atrial myxoma or non-endothelialized cyst of the mitral valve&#46;<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">24&#44;30</span></a> Color flow Doppler helps distinguish an aneurysm from other similar-looking abnormalities by demonstrating direct communication between the aneurysm and the left ventricle&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">22</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Potential complications of these aneurysms include rupture&#44; thromboembolism and recurrent infection&#46; MVAs can also cause severe mitral regurgitation due to perforation of the aneurysm or as a result of leaflet coaptation defect caused by the mass effect of the aneurysm&#44; and may precipitate rapid deterioration of hemodynamic status&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The optimal management strategy for MVAs has not yet been well defined&#46; A few reports have shown that conservative management of uncomplicated MVAs&#44; with close follow-up&#44; is possible&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">2&#44;31</span></a> In cases of MVA rupture or severe mitral regurgitation or if the patient needs aortic valve replacement surgery&#44; then mitral valve surgery should be considered&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">4&#44;15&#44;31</span></a> Conservative mitral valve surgery for aneurysm correction is not always possible&#59; it depends on the degree of valve destruction and the anatomic disorder&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">32</span></a> When it is unsuitable for repair&#44;<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">32&#8211;34</span></a> mitral valve replacement may be the only viable option&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">25&#44;35&#44;36</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In conclusion&#44; MVAs are rare but potentially life-threatening complications and should be carefully considered in the evaluation of every patient with aortic valve endocarditis&#46; We report a case with impressive images of aortic valve endocarditis complicated by perforated mitral valve aneurysm and severe mitral regurgitation&#44; diagnosed by TEE&#46; This case highlights the importance of early diagnosis with appropriate imaging and timely surgical intervention to prevent fatal outcomes&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Ethical disclosures</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Protection of human and animal subjects</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Confidentiality of data</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Right to privacy and informed consent</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conflicts of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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            0 => "V&#225;lvula mitral"
            1 => "Aneurisma"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mitral valve aneurysms are rare and occur most commonly in association with aortic valve endocarditis&#46; Transesophageal echocardiography is the most sensitive imaging modality for the diagnosis of this entity and its potential complications&#44; such as leaflet rupture and mitral regurgitation&#44; which mandate prompt surgical intervention&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We present the case of a 70-year-old male patient with aortic valve endocarditis complicated with a ruptured aneurysm of the anterior mitral valve leaflet and associated severe mitral regurgitation&#44; diagnosed by transesophageal echocardiography&#44; with impressive images&#46; We hypothesized that the aneurysm developed through direct extension of infection from the aortic valve or from a prolapsing aortic vegetation&#44; with abscess formation and subsequent rupture and drainage&#46; This case highlights the importance of appropriate imaging for early detection and timely surgical intervention &#40;repair or replacement&#41; to prevent fatal outcomes&#46;</p></span>"
      ]
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Os aneurismas da v&#225;lvula mitral s&#227;o raros e&#44; habitualmente&#44; encontram-se associados a endocardite da v&#225;lvula a&#243;rtica&#46; O ecocardiograma transesof&#225;gico &#233; a modalidade imagiol&#243;gica mais sens&#237;vel para o diagn&#243;stico desta entidade e das suas potenciais complica&#231;&#245;es&#44; tais como perfura&#231;&#227;o e regurgita&#231;&#227;o mitral&#44; que exigem interven&#231;&#227;o cir&#250;rgica urgente&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Apresentamos o caso cl&#237;nico de um doente de 70 anos&#44; do sexo masculino&#44; com endocardite da v&#225;lvula a&#243;rtica complicada por aneurisma perfurado do folheto anterior da v&#225;lvula mitral e regurgita&#231;&#227;o mitral grave associada&#44; diagnosticada por ecocardiograma transesof&#225;gico com imagens muito ilustrativas&#46; Admitimos como hip&#243;tese&#44; mais prov&#225;vel&#44; que o aneurisma se desenvolveu por extens&#227;o direta da infe&#231;&#227;o a partir da v&#225;lvula a&#243;rtica ou do prolapso de uma vegeta&#231;&#227;o a&#243;rtica&#44; com forma&#231;&#227;o de abcesso e subsequente rotura e drenagem&#46; Este caso real&#231;a a import&#226;ncia das modalidades imagiol&#243;gicas adequadas no diagn&#243;stico precoce do aneurisma da v&#225;lvula mitral e da interven&#231;&#227;o cir&#250;rgica atempada &#40;plastia ou substitui&#231;&#227;o&#41; na preven&#231;&#227;o de eventos fatais&#46;</p></span>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Transthoracic echocardiogram &#40;parasternal long-axis view&#41;&#46; &#40;A&#41; Saccular bulge on the atrial side of the anterior mitral valve leaflet &#40;small arrow&#41; and a vegetation on the aortic valve prolapsing into the left ventricular outflow tract&#44; in close contact with the anterior mitral valve leaflet &#40;long arrow&#41;&#59; &#40;B&#41; significant mitral regurgitation &#40;color flow Doppler&#41;&#46;</p>"
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Transesophageal echocardiogram&#46; &#40;A&#41; 2-chamber view&#58; saccular bulge &#40;aneurysm&#41; on the atrial side of the anterior mitral valve leaflet &#40;arrow&#41;&#59; &#40;B&#41; 5-chamber view&#58; bilobular image &#40;aneurysm&#41; on the atrial side of the anterior mitral valve leaflet &#40;arrow&#41;&#46;</p>"
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          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Transesophageal echocardiogram &#40;3-chamber view&#41;&#46; &#40;A&#41; Ruptured aneurysm of the anterior mitral valve leaflet&#46; The long arrow points to the entry site and the small arrow points to the exit site of the aneurysm&#59; &#40;B&#41; color Doppler image showing two mitral regurgitation jets&#58; a small jet through the leaflet coaptation point &#40;small arrow&#41; and a much more significant one through the aneurysm &#40;long arrow&#41;&#46;</p>"
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Case report
Mitral valve aneurysm: A serious complication of aortic valve endocarditis
Aneurisma da válvula mitral: uma complicação grave da endocardite valvular aórtica
Maria João Sousa
Autor para correspondência
maria.sousa.101@sapo.pt

Corresponding author.
, Vasco Alves, Sofia Cabral, Nuno Antunes, Luís Sousa Pereira, Filomena Oliveira, João Silveira, Severo Torres
Serviço de Cardiologia, Centro Hospitalar do Porto, Porto, Portugal
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Case report</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 70-year-old male patient with type 2 diabetes mellitus and chronic hepatitis C virus infection presented to the emergency department with a four-month history of intermittent fever&#44; night sweats&#44; weight loss and progressive dyspnea&#46; There was no past history of cardiovascular disease or illicit drug abuse&#46; On physical examination&#44; he was febrile &#40;38&#46;1<span class="elsevierStyleHsp" style=""></span>&#176;C&#41;&#44; his pulse was 124 bpm&#44; blood pressure was 114&#47;73 mmHg and he had signs of left heart failure&#46; Cardiac auscultation disclosed a grade 3&#47;6 pansystolic murmur at the apex&#46; Blood cultures were positive for <span class="elsevierStyleItalic">Streptococcus viridans</span>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Transthoracic echocardiography &#40;TTE&#41; showed multiple aortic valve vegetations &#40;some prolapsing into the left ventricular outflow tract&#41;&#44; mild aortic regurgitation and a large saccular bulge originating from the anterior mitral valve leaflet and protruding into the left atrium with severe mitral regurgitation &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#59; left ventricular systolic function was normal&#46; With transesophageal echocardiography &#40;TEE&#41; it became clear that the saccular bulging on the mitral valve was an anterior mitral valve leaflet aneurysm with two rupture sites &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#46; Color flow Doppler showed two regurgitant jets&#58; one through the coaptation margin of the mitral valve leaflets and the other across the perforated aneurysm &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>&#41;&#46; There was no evidence of either aortic ring abscess formation or extension along the mitral-aortic intervalvular fibrosa&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Antibiotic therapy was started with vancomycin plus gentamicin &#40;due to penicillin allergy&#41; for infective endocarditis &#40;IE&#41;&#46; After clinical stabilization&#44; he was referred for urgent cardiac surgery&#46; Given his clinical stability&#44; surgery was delayed for four more days of antibiotic therapy&#46; The patient died suddenly one day before scheduled surgical intervention&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">Mitral valve aneurysms &#40;MVAs&#41; are uncommon but potentially serious complications&#44; occurring most frequently in association with aortic valve endocarditis&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">1&#8211;4</span></a> The first case was reported by Morand in 1729&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">5</span></a> In 1970&#44; Gonzalez-Lavin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">6</span></a> reported secondary involvement of the mitral valve with leaflet aneurysm in two &#40;3&#46;4&#37;&#41; patients out of 58 who underwent aortic valve surgery for IE&#46; Similar results were reported in 1992 by Karalis et al&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">7</span></a> in a group of 55 patients with aortic valve endocarditis evaluated by TEE&#46; More recent reports present a very low incidence&#44; around 0&#46;2-0&#46;29&#37; of patients who undergo TEE&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">2&#44;4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Although most frequently associated with IE&#44; other non-infectious etiologies have been reported including congenital cardiac structural defects&#44; extreme forms of mitral valve prolapse&#44; Libman-Sacks endocarditis and connective tissue disorders such as Marfan syndrome&#44; Ehlers-Danlos syndrome&#44; pseudoxanthoma elasticum and osteogenesis imperfecta&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">4&#44;9&#8211;13</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Because MVA is rare in the absence of IE&#44; an infectious etiology will be at least partly responsible for leaflet degeneration&#46; Proposed mechanisms for the development of MVA in the setting of aortic valve endocarditis include direct extension of the infection through the mitral-aortic intervalvular fibrosa to the anterior mitral valve leaflet with abscess formation and subsequent drainage&#44; seeding of the anterior mitral valve leaflet by the aortic regurgitant jet &#40;&#8216;jet lesion&#8217;&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">1&#44;3&#44;8&#44;14&#8211;16</span></a> or through direct contact with an aortic vegetation prolapsing into the left ventricular outflow tract &#40;&#8216;kissing vegetation&#8217;&#41;&#44; especially if the vegetation exceeds 6 mm in size&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">17</span></a> These processes are thought to cause localized inflammation&#44; weakness&#44; dissection&#44; and subsequent expansion of the valvular tissue&#44; which in turn protrudes toward the left atrium due to ventricular systolic pressure&#44; leading to aneurysm formation&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">2&#44;18&#8211;21</span></a> In our case&#44; because aortic regurgitation was only mild&#44; we believe that the most likely mechanism for aneurysm development was previous abscess formation &#40;secondary to direct extension of infection from the aortic valve or a prolapsing aortic vegetation&#41; followed by rupture and drainage&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The diagnosis may be suspected by TTE but TEE is more sensitive for detecting MVA&#44; leaflet rupture and mitral regurgitation&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">2&#44;4&#44;22&#8211;25</span></a> Recently&#44; a few reports have highlighted the role of real-time three-dimensional echocardiography to better define the anatomical features of MVA preoperatively&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">16&#44;26&#8211;28</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Echocardiography shows MVA as a localized saccular bulge of the mitral valve leaflet toward the left atrium communicating with the left ventricle&#44; expanding in systole and collapsing in diastole&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">2</span></a> Diastolic expansion can occur in cases of MVA rupture or severe aortic regurgitation&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">28</span></a> These lesions can vary from a few mm to 4 cm in diameter and may contain thrombi&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">8</span></a> The anterior leaflet is much more commonly involved than the posterior leaflet&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">2&#8211;4</span></a> The diagnosis of perforation is based on the presence of a high-velocity regurgitant jet traversing the aneurysm in systole and further supported by demonstration of an interrupted segment of the aneurysm by two-dimensional examination&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">4&#44;29</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">MVA must be differentiated from various abnormalities with similar echocardiographic appearance including severe mitral valve prolapse&#44; diverticulum of the mitral valve&#44; large valvular vegetation&#44; flail valve leaflet&#44; blood cyst of the papillary muscle&#44; cystic atrial myxoma or non-endothelialized cyst of the mitral valve&#46;<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">24&#44;30</span></a> Color flow Doppler helps distinguish an aneurysm from other similar-looking abnormalities by demonstrating direct communication between the aneurysm and the left ventricle&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">22</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Potential complications of these aneurysms include rupture&#44; thromboembolism and recurrent infection&#46; MVAs can also cause severe mitral regurgitation due to perforation of the aneurysm or as a result of leaflet coaptation defect caused by the mass effect of the aneurysm&#44; and may precipitate rapid deterioration of hemodynamic status&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The optimal management strategy for MVAs has not yet been well defined&#46; A few reports have shown that conservative management of uncomplicated MVAs&#44; with close follow-up&#44; is possible&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">2&#44;31</span></a> In cases of MVA rupture or severe mitral regurgitation or if the patient needs aortic valve replacement surgery&#44; then mitral valve surgery should be considered&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">4&#44;15&#44;31</span></a> Conservative mitral valve surgery for aneurysm correction is not always possible&#59; it depends on the degree of valve destruction and the anatomic disorder&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">32</span></a> When it is unsuitable for repair&#44;<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">32&#8211;34</span></a> mitral valve replacement may be the only viable option&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">25&#44;35&#44;36</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In conclusion&#44; 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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Os aneurismas da v&#225;lvula mitral s&#227;o raros e&#44; habitualmente&#44; encontram-se associados a endocardite da v&#225;lvula a&#243;rtica&#46; O ecocardiograma transesof&#225;gico &#233; a modalidade imagiol&#243;gica mais sens&#237;vel para o diagn&#243;stico desta entidade e das suas potenciais complica&#231;&#245;es&#44; tais como perfura&#231;&#227;o e regurgita&#231;&#227;o mitral&#44; que exigem interven&#231;&#227;o cir&#250;rgica urgente&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Apresentamos o caso cl&#237;nico de um doente de 70 anos&#44; do sexo masculino&#44; com endocardite da v&#225;lvula a&#243;rtica complicada por aneurisma perfurado do folheto anterior da v&#225;lvula mitral e regurgita&#231;&#227;o mitral grave associada&#44; diagnosticada por ecocardiograma transesof&#225;gico com imagens muito ilustrativas&#46; Admitimos como hip&#243;tese&#44; mais prov&#225;vel&#44; que o aneurisma se desenvolveu por extens&#227;o direta da infe&#231;&#227;o a partir da v&#225;lvula a&#243;rtica ou do prolapso de uma vegeta&#231;&#227;o a&#243;rtica&#44; com forma&#231;&#227;o de abcesso e subsequente rotura e drenagem&#46; Este caso real&#231;a a import&#226;ncia das modalidades imagiol&#243;gicas adequadas no diagn&#243;stico precoce do aneurisma da v&#225;lvula mitral e da interven&#231;&#227;o cir&#250;rgica atempada &#40;plastia ou substitui&#231;&#227;o&#41; na preven&#231;&#227;o de eventos fatais&#46;</p></span>"
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          0 => array:4 [
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Transthoracic echocardiogram &#40;parasternal long-axis view&#41;&#46; &#40;A&#41; Saccular bulge on the atrial side of the anterior mitral valve leaflet &#40;small arrow&#41; and a vegetation on the aortic valve prolapsing into the left ventricular outflow tract&#44; in close contact with the anterior mitral valve leaflet &#40;long arrow&#41;&#59; &#40;B&#41; significant mitral regurgitation &#40;color flow Doppler&#41;&#46;</p>"
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        "tipo" => "MULTIMEDIAFIGURA"
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Transesophageal echocardiogram&#46; &#40;A&#41; 2-chamber view&#58; saccular bulge &#40;aneurysm&#41; on the atrial side of the anterior mitral valve leaflet &#40;arrow&#41;&#59; &#40;B&#41; 5-chamber view&#58; bilobular image &#40;aneurysm&#41; on the atrial side of the anterior mitral valve leaflet &#40;arrow&#41;&#46;</p>"
        ]
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        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
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          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Transesophageal echocardiogram &#40;3-chamber view&#41;&#46; &#40;A&#41; Ruptured aneurysm of the anterior mitral valve leaflet&#46; The long arrow points to the entry site and the small arrow points to the exit site of the aneurysm&#59; &#40;B&#41; color Doppler image showing two mitral regurgitation jets&#58; a small jet through the leaflet coaptation point &#40;small arrow&#41; and a much more significant one through the aneurysm &#40;long arrow&#41;&#46;</p>"
        ]
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ISSN: 08702551
Idioma original: Inglês
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