Artigo Original
A decisão de não revascularizar o enfarte agudo do miocárdio sem supradesnivelamento de ST – condicionantes e prognóstico. A realidade nacional
A conservative strategy in non‐ST‐segment elevation myocardial infarction – constraints and prognosis: The situation in Portugal
Davide Moreira
, Bruno Marmelo, Anne Delgado, Luís Nunes, João Pipa, Oliveira Santos, em nome dos investigadores do Registo Nacional de Síndromes Coronárias Agudas
Autor para correspondência
Serviço de Cardiologia, Centro Hospitalar Tondela‐Viseu, Viseu, Portugal
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A realidade nacional" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1028 "Ancho" => 3132 "Tamanyo" => 134858 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Kaplan-Meier survival curves for mortality in the three groups over a one-year follow-up according to GRACE score risk categories.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Davide Moreira, Bruno Marmelo, Anne Delgado, Luís Nunes, João Pipa, Oliveira Santos" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Davide" "apellidos" => "Moreira" ] 1 => array:2 [ "nombre" => "Bruno" "apellidos" => "Marmelo" ] 2 => array:2 [ "nombre" => "Anne" "apellidos" => "Delgado" ] 3 => array:2 [ "nombre" => "Luís" "apellidos" => "Nunes" ] 4 => array:2 [ "nombre" => "João" "apellidos" => "Pipa" ] 5 => array:2 [ "nombre" => "Oliveira" "apellidos" => "Santos" ] 6 => array:1 [ "colaborador" => "on behalf of researchers from the National Registry of Acute Coronary Syndromes" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S0870255115000360" "doi" => "10.1016/j.repc.2014.10.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115000360?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915000732?idApp=UINPBA00004E" "url" => "/21742049/0000003400000005/v1_201506091454/S2174204915000732/v1_201506091454/en/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S0870255115001067" "issn" => "08702551" "doi" => "10.1016/j.repc.2014.11.017" "estado" => "S300" "fechaPublicacion" => "2015-05-01" "aid" => "637" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2015;34:329-35" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5574 "formatos" => array:3 [ "EPUB" => 202 "HTML" => 4684 "PDF" => 688 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Relationship between severity of pulmonary hypertension and coronary sinus diameter" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "329" "paginaFinal" => "335" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Relação entre a gravidade da hipertensão pulmonar e o diâmetro do seio coronário" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1128 "Ancho" => 1658 "Tamanyo" => 115333 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Measurement of right atrial area using the planimetry method from apical 4-chamber view. 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A realidade nacional" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "315" "paginaFinal" => "328" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Davide Moreira, Bruno Marmelo, Anne Delgado, Luís Nunes, João Pipa, Oliveira Santos" "autores" => array:7 [ 0 => array:4 [ "nombre" => "Davide" "apellidos" => "Moreira" "email" => array:1 [ 0 => "davidasmoreira@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Bruno" "apellidos" => "Marmelo" ] 2 => array:2 [ "nombre" => "Anne" "apellidos" => "Delgado" ] 3 => array:2 [ "nombre" => "Luís" "apellidos" => "Nunes" ] 4 => array:2 [ "nombre" => "João" "apellidos" => "Pipa" ] 5 => array:2 [ "nombre" => "Oliveira" "apellidos" => "Santos" ] 6 => array:1 [ "colaborador" => "em nome dos investigadores do Registo Nacional de Síndromes Coronárias Agudas" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Serviço de Cardiologia, Centro Hospitalar Tondela‐Viseu, Viseu, Portugal" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondência." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "A conservative strategy in non‐ST‐segment elevation myocardial infarction – constraints and prognosis: The situation in Portugal" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1034 "Ancho" => 3126 "Tamanyo" => 130137 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Curvas de Kaplan‐Meier com a evolução da mortalidade dos grupos ao longo do período de um ano, de acordo com os estratos de risco do <span class="elsevierStyleItalic">score</span> GRACE.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introdução</span><p id="par0005" class="elsevierStylePara elsevierViewall">A revascularização no enfarte agudo do miocárdio sem supradesnivelamento de ST (EAMSST) permite o alívio de sintomas, diminui o tempo de internamento e melhora o prognóstico<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">1–3</span></a>. No entanto, as indicações e o <span class="elsevierStyleItalic">timing</span> para revascularização miocárdica dependem de vários fatores, alguns intrínsecos ao doente − como a idade, o género e as comorbilidades – e outros extrínsecos, como a disponibilidade de meios. Por conseguinte e apesar da estratégia invasiva combinada com terapêutica médica otimizada se encontrar associada a aumento da sobrevida em todas as idades<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">4</span></a>, sabe‐se que a abordagem terapêutica é mais seletiva nos indivíduos mais velhos na qual a presença de comorbilidades é reconhecida como uma limitação à realização de coronariografia<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">1,5</span></a>. Relativamente às desigualdades de género, vários estudos mostram que as mulheres são menos submetidas a coronariografia do que os homens<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">6</span></a>, apesar de o benefício similar<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">7</span></a>. Por outro lado, os dados do registo <span class="elsevierStyleItalic">Global Registry of Acute Coronary Events</span> (GRACE), o maior registo multinacional de doentes com síndrome coronária aguda (SCA) – mostram que existe uma relação inversa entre o risco do doente e a realização de coronariografia<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">8</span></a>. Estes factos mostram a complexidade da análise dos fatores que determinam a estratégia terapêutica dado que a decisão de realização de coronariografia depende dos meios existentes, dos protocolos intra‐hospitalares e principalmente da decisão médica individual.</p><p id="par0010" class="elsevierStylePara elsevierViewall">O objetivo deste trabalho é descrever e estudar o impacto da estratégia conservadora na abordagem das SCA, na fase hospitalar e no médio prazo.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">População e métodos</span><p id="par0015" class="elsevierStylePara elsevierViewall">Das bases de dados do Registo Nacional de Síndromes Coronárias Agudas (RNSCA) e da Sociedade Portuguesa de Cardiologia considerou‐se, no período compreendido entre 1 de outubro de 2010 e 1 de outubro de 2013, uma população de 3799 doentes com EAMSST, definido pela elevação de marcadores de lesão miocárdica<span class="elsevierStyleHsp" style=""></span>−<span class="elsevierStyleHsp" style=""></span>troponina ou isoenzima MB da creatina quinase (CK‐MB)<span class="elsevierStyleHsp" style=""></span>−<span class="elsevierStyleHsp" style=""></span>em contexto de sintomatologia compatível com isquemia miocárdica e sem elevação persistente (<<span class="elsevierStyleHsp" style=""></span>30 minutos) do segmento ST no eletrocardiograma (ECG) de 12 derivações considerado para o diagnóstico. Consideraram‐se os doentes com informação sobre realização de coronariografia e/ou realização de intervenção coronária percutânea (ICP) (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3780). Definiu‐se estratégia conservadora pela não realização de coronariografia e estratégia invasiva pela realização de coronariografia durante o internamento, que poderia ser seguida ou não de realização de ICP. Definiu‐se a gravidade das lesões coronárias como não significativas se estenose<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>50%, significativas estenose ≥<span class="elsevierStyleHsp" style=""></span>50% e<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>100% e oclusão com estenose de 100%. Definiu‐se vaso tratado por ICP pelos critérios do RNSCA, isto é, por lesão residual inferior a 30% e fluxo TIMI 3 no final da angioplastia. Procedeu‐se à distribuição em três grupos: o grupo 1 incluiu os doentes submetidos a estratégia conservadora (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>623), o grupo 2 incluiu os doentes submetidos a coronariografia mas não submetidos a ICP (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1229) e o grupo 3 incluiu os doentes submetidos a coronariografia e a ICP (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1928). Compararam‐se os grupos com base em critérios clínicos e relacionados com o procedimento e complicações intra‐hospitalares (CIH), nomeadamente: (1) reenfarte, definido no RNSCA por recorrência de dor torácica sugestiva de isquemia, após resolução do episódio da dor de admissão, com duração superior a 20 minutos, acompanhada de alterações eletrocardiográficas e de nova elevação dos biomarcadores de lesão miocárdica em relação ao valor prévio (elevação de CK‐MB duas vezes o valor de referência ou ><span class="elsevierStyleHsp" style=""></span>50% do valor prévio; ou elevação de ><span class="elsevierStyleHsp" style=""></span>20% do valor da troponina <span class="elsevierStyleSmallCaps">I</span> ou da troponina T em relação ao valor prévio); (2) insuficiência cardíaca (IC); (3) complicação mecânica definida por rutura da parede livre do miocárdio ou rutura do septo interventricular ou insuficiência mitral aguda grave por envolvimento dos músculos papilares; (4) fibrilhação auricular (FA) <span class="elsevierStyleItalic">de novo</span>, definida pela presença de forma paroxística ou persistente, de FA que não existia previamente ao internamento; (5) bloqueio auriculoventricular (BAV) de 2.° grau Mobitz 2 ou graus mais avançados; (6) taquicardia ventricular (TV) mantida – definida pela presença, durante o internamento hospitalar, de TV monomórfica ou polimórfica com duração superior a 30 segundos ou associada a instabilidade hemodinâmica; (7) paragem cardíaca ressuscitada – ocorrência de paragem cardíaca durante o internamento hospitalar, ressuscitada com êxito, independentemente da causa; (8) acidente vascular cerebral (AVC) isquémico ou AVC hemorrágico; (9) hemorragia <span class="elsevierStyleItalic">major –</span> definida pela ocorrência durante o internamento hospitalar de hemorragia intracraniana ou hemorragia com compromisso hemodinâmico requerendo intervenção de acordo com a classificação de GUSTO<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">9</span></a> ou necessidade de transfusão com concentrado de eritrócitos. Foi determinado o destino após alta hospitalar e foi realizado seguimento clínico num período de até um ano após alta hospitalar.</p><p id="par0020" class="elsevierStylePara elsevierViewall">O <span class="elsevierStyleItalic">endpoint</span> primário foi definido pela mortalidade intra‐hospitalar (MIH) ou pela mortalidade ao fim de um ano (M1ano), por qualquer causa. O <span class="elsevierStyleItalic">endpoint</span> secundário foi definido pela presença de pelo menos uma das seguintes CIH durante o internamento: hemorragia <span class="elsevierStyleItalic">major</span> ou necessidade de transfusão com concentrado de eritrócitos, ou necessidade de ventilação mecânica invasiva – se utilizado tubo traqueal, máscara laríngea ou traqueostomia como interface ventilador‐doente<span class="elsevierStyleHsp" style=""></span>−<span class="elsevierStyleHsp" style=""></span>ou IC congestiva ou reenfarte.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Na análise estatística, as variáveis categóricas foram caracterizadas por intermédio de frequências absolutas e frequências relativas; as diferenças das proporções entre os grupos foram avaliadas recorrendo ao teste qui‐quadrado assintótico e ao teste qui‐quadrado com método de Monte Carlo, quando os pressupostos de utilização do primeiro não foram satisfeitos. As variáveis contínuas foram caracterizadas recorrendo à média, desvio padrão, quartis, mínimo e máximo. A ANOVA foi usada para comparar médias dos grupos; quando os pressupostos desta não foram satisfeitos, considerou‐se o teste Kruskal‐Wallis para comparar a distribuição dos valores das variáveis contínuas. A normalidade da distribuição dos valores das variáveis contínuas e a igualdade das suas variâncias foram testadas através do teste Kolmogorov‐Smirnov e do teste de Levene, respetivamente. Foram construídos dois modelos de regressão logística, um para a MIH e outro para as CIH, de forma a averiguar se a não realização de estratégia invasiva é um preditor de mau prognóstico. Considerou‐se o método <span class="elsevierStyleItalic">stepwise forward</span> para a seleção das variáveis a incluir no modelo final; os valores p considerados na remoção e na inclusão das variáveis no modelo foram de 0,10 e 0,05, respetivamente. O efeito da variável definidora dos três grupos na ocorrência de cada um dos <span class="elsevierStyleItalic">endpoints</span> foi ajustado pela inclusão dos seguintes potenciais confundidores: género, idade, índice de massa corporal (IMC), antecedentes patológicos e fatores de risco cardiovascular (FRCV), dados do exame físico na admissão, parâmetros laboratoriais, medicação prévia ao evento, medicação administrada no internamento e a avaliação da fração de ejeção ventricular esquerda (FEVE). No caso da MIH foram ainda consideradas as CIH. A calibração dos modelos foi testada por intermédio do teste Hosmer‐Lemeshow e considerou‐se a medida <span class="elsevierStyleItalic">c‐statistic</span> para avaliar as suas capacidades discriminatórias. O risco de ocorrência de cada um dos <span class="elsevierStyleItalic">endpoints</span> associado a cada preditor foi estimado por intermédio do <span class="elsevierStyleItalic">odds ratio</span> e do respetivo intervalo de confiança a 95% (IC95%). A avaliação do efeito da estratégia terapêutica na M1ano foi avaliada a partir da construção de um modelo de regressão de Cox. Também aqui se considerou o método de seleção <span class="elsevierStyleItalic">stepwise forward</span> com valores p de 0,10 e 0,05, para remoção e inclusão, respetivamente. Consideraram‐se os mesmos potenciais confundidores utilizados para a MIH e, adicionalmente, a medicação na alta. O risco de M1ano, associado a cada preditor, foi estimado por intermédio do <span class="elsevierStyleItalic">hazard ratio</span> e do respetivo IC95%. Finalmente, procedeu‐se à estratificação do risco dos doentes de acordo com os seguintes tercis do <span class="elsevierStyleItalic">score</span> GRACE<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">2</span></a>: risco baixo (≤<span class="elsevierStyleHsp" style=""></span>108), risco intermédio (109‐140) e risco alto (><span class="elsevierStyleHsp" style=""></span>140).</p><p id="par0030" class="elsevierStylePara elsevierViewall">Foi utilizado o <span class="elsevierStyleItalic">software</span> IBM® SPSS® <span class="elsevierStyleItalic">Statistics</span> (versão 19.0.0.2) para a realização de toda a análise estatística. Os testes foram realizados ao nível de significância de 5%.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Caracterização da população</span><p id="par0035" class="elsevierStylePara elsevierViewall">A distribuição da população pelos grupos foi a seguinte: grupo 1 – 16,5%; grupo 2 – 32,5%; grupo 3 – 51,0%. As características gerais encontram‐se na <a class="elsevierStyleCrossRef" href="#tbl0005">Tabela 1</a>. Constata‐se a maior prevalência do género masculino em todos os grupos e a sua maior prevalência nos grupos submetidos a estratégia invasiva. Os doentes do grupo 1 são mais velhos, têm maior prevalência de FRCV, de doença coronária identificada<span class="elsevierStyleHsp" style=""></span>−<span class="elsevierStyleHsp" style=""></span>e de procedimentos de revascularização miocárdica – de doença vascular periférica e de comorbilidades como IC, doença pulmonar obstrutiva crónica, demência, doença cerebrovascular e doença renal crónica (DRC) – definida no RNSCA como creatininemia prévia ao internamento ><span class="elsevierStyleHsp" style=""></span>2,0<span class="elsevierStyleHsp" style=""></span>mg/dl ou realização de diálise ou antecedentes de transplante renal. Nos parâmetros laboratoriais, destacam‐se os valores mais elevados de creatinina na admissão e creatinina máxima – em concordância com a maior prevalência de DRC – bem como valores mais baixos de hemoglobina e valores mais elevados de <span class="elsevierStyleItalic">brain natriuretic peptide</span> (BNP) e da porção N‐terminal do BNP (NT‐pro‐BNP) no grupo 1. Na admissão hospitalar os doentes submetidos a estratégia conservadora têm maior prevalência de IC com classe de Killip‐Kimball ><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">I</span>, de FA e de infradesnivelamento do segmento ST – definido pelo infradesnivelamento de ST horizontal ou em rampa descendente, superior a 0,5<span class="elsevierStyleHsp" style=""></span>mm (0,05<span class="elsevierStyleHsp" style=""></span>mV) em duas ou mais derivações contíguas. Por último, constata‐se a maior percentagem de doentes no estrato de alto risco do <span class="elsevierStyleItalic">score</span> GRACE no grupo da estratégia conservadora, com diferença significativa; por outro lado, o grupo dos doentes submetidos a coronariografia e ICP apresenta as maiores percentagens de doentes nos estratos de risco baixo e risco intermédio e menor percentagem de doentes no estrato de risco elevado.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Terapêutica farmacológica realizada no internamento</span><p id="par0040" class="elsevierStylePara elsevierViewall">Na <a class="elsevierStyleCrossRef" href="#tbl0010">Tabela 2</a> é apresentada a terapêutica farmacológica cardiovascular realizada durante o internamento. A análise mostra que os doentes do grupo 1 usufruem menos de terapêuticas com comprovado benefício na diminuição da morbilidade e mortalidade no contexto de SCA, nomeadamente a antiagregação plaquetária, inibidores do sistema renina‐angiotensina‐aldosterona, betabloqueadores e estatinas. Por outro lado constata‐se a maior utilização de diuréticos e de inotrópicos neste grupo – provavelmente decorrente da maior prevalência de IC.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Terapêutica invasiva e avaliação da função ventricular esquerda</span><p id="par0045" class="elsevierStylePara elsevierViewall">A <a class="elsevierStyleCrossRef" href="#tbl0015">Tabela 3</a> mostra as características da população nas variáveis relacionadas com o procedimento. Destaca‐se a ampla utilização do acesso radial em ambos os grupos de estratégia invasiva. Constata‐se a maior prevalência de doença do tronco comum e de doença de três vasos no grupo 2, enquanto o grupo 3 tem maior prevalência de doença de um vaso e de dois vasos. Destaca‐se também a prevalência elevada de vaso responsável pelo SCA não identificado no grupo 2. Relativamente ao tratamento por ICP verifica‐se que este foi executado sobretudo nos doentes com doença de um vaso.</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Por último, destaca‐se a existência de diferença significativa na avaliação da FEVE – que é menos frequentemente realizada no grupo da estratégia conservadora – e a diferença significativa no seu valor – que é inferior no grupo 1 e superior no grupo 3.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Complicações, mortalidade intra‐hospitalar e destino pós‐alta hospitalar</span><p id="par0055" class="elsevierStylePara elsevierViewall">A análise da <a class="elsevierStyleCrossRef" href="#tbl0020">Tabela 4</a> mostra a mediana da duração de internamento nos grupos, a MIH, a CIH e o destino após alta hospitalar.</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">A MIH global foi de 2,0%, significativamente mais elevada no grupo 1. Constata‐se também que a MIH no estrato de risco alto do <span class="elsevierStyleItalic">score</span> GRACE é significativamente mais elevada no grupo da estratégia conservadora, o que não se verifica nos outros estratos de risco. Por outro lado, o <span class="elsevierStyleItalic">endpoint</span> secundário é mais frequente no grupo 1 (37,2% <span class="elsevierStyleItalic">versus</span> 18,9% <span class="elsevierStyleItalic">versus</span> 14,6%, p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001). Esta diferença constata‐se também na ocorrência de complicações definidas de acordo com os critérios GUSTO e estratificadas pelo <span class="elsevierStyleItalic">score</span> GRACE como sendo de risco intermédio e risco alto. Destaca‐se o facto de o reenfarte constituir a única complicação menos frequente no grupo 1.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Relativamente à realização de cirurgia de pontagem aorto‐coronária verifica‐se que o grupo 2 foi o mais frequentemente orientado para esta intervenção, o que está em consonância com a maior prevalência de doença de três vasos e de doença do tronco comum.</p><p id="par0070" class="elsevierStylePara elsevierViewall">A análise multivariada permitiu identificar os preditores de MIH e dos preditores de CIH definidoras do <span class="elsevierStyleItalic">endpoint</span> secundário, que se encontram nas <a class="elsevierStyleCrossRefs" href="#tbl0025">Tabelas 5 e 6</a>.</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><elsevierMultimedia ident="tbl0030"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Os preditores de MIH foram a adoção de estratégia conservadora, a idade, infradesnivelamento do segmento ST no ECG de admissão, depressão grave da FEVE, a ocorrência de paragem cardíaca ressuscitada, ou de IC congestiva, ou de hemorragia <span class="elsevierStyleItalic">major</span> ou de AVC e a utilização de inotrópicos. A realização de coronariografia e não‐realização de ICP não foi um preditor identificado de MIH (OR 1,737; IC95% [0,617‐4,891], p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,296).</p><p id="par0080" class="elsevierStylePara elsevierViewall">Os preditores identificados de CIH definidas no <span class="elsevierStyleItalic">endpoint</span> secundário foram: adoção de estratégia conservadora, idade, infradesnivelamento do segmento ST no ECG de admissão, depressão grave da FEVE, classe Killip‐Kimball ><span class="elsevierStyleHsp" style=""></span>I na admissão, a doença vascular periférica e o valor da hemoglobina inicial. A realização de coronariografia e não‐realização de ICP não foi um preditor identificado de CIH definidas no <span class="elsevierStyleItalic">endpoint</span> secundário (OR 0,933; IC95% [0,701‐1,243], p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,637).</p><p id="par0085" class="elsevierStylePara elsevierViewall">Em notável contraste com outra outras estratégias terapêuticas constata‐se que os doentes submetidos a estratégia conservadora são os mais frequentemente encaminhados para realização de reabilitação cardíaca.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Medicação na alta hospitalar</span><p id="par0090" class="elsevierStylePara elsevierViewall">A <a class="elsevierStyleCrossRef" href="#tbl0035">Tabela 7</a> mostra a medicação prescrita à data de alta hospitalar; destaca‐se a menor utilização de dupla antigregação plaquetária, de betabloqueadores e de IECA/ARA‐II nos doentes submetidos a estratégia conservadora. Por outro lado, estes têm as mais elevadas taxas de prescrição de diuréticos de ansa, de antagonistas da aldosterona, amiodarona e digoxina – o que está em concordância com a maior prevalência de IC e FA.</p><elsevierMultimedia ident="tbl0035"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Mortalidade um ano após alta hospitalar e respetivos preditores</span><p id="par0095" class="elsevierStylePara elsevierViewall">A análise da <a class="elsevierStyleCrossRef" href="#tbl0040">Tabela 8</a> mostra que a M1ano é significativamente superior no grupo 1. Para a construção do modelo de regressão de Cox foram incluídos 564 doentes; o número de mortos ao fim de um ano foi de 48 (8,5%). Os preditores de M1ano foram a adoção de estratégia conservadora, a idade, infradesnivelamento do segmento ST no ECG de admissão, FEVE<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>50%, o valor mínimo da hemoglobina e a ocorrência de TV ou de AVC durante o internamento. A realização de coronariografia e não‐realização de ICP não foi um preditor de M1ano (HR 1,267; IC95% [0,573‐2,8], p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,559). A <a class="elsevierStyleCrossRef" href="#fig0005">Figura 1</a> mostra as curvas de Cox da evolução da mortalidade nos grupos ao longo do período de um ano.</p><elsevierMultimedia ident="tbl0040"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">A <a class="elsevierStyleCrossRef" href="#tbl0045">Tabela 9</a> mostra que, com estratificação pelo <span class="elsevierStyleItalic">score</span> GRACE, a M1ano é significativamente superior nos estratos de risco intermédio e alto; a <a class="elsevierStyleCrossRef" href="#fig0010">Figura 2</a> mostra as curvas de Kaplan‐Meier da evolução da mortalidade nos três estratos ao longo deste período.</p><elsevierMultimedia ident="tbl0045"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussão</span><p id="par0105" class="elsevierStylePara elsevierViewall">A análise dos determinantes da decisão de revascularização no EAMSST é complexa, dada a heterogeneidade desta população em termos de risco e de prognóstico<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">2</span></a>. Por conseguinte, é recomendada a estratificação do risco de modo a identificar os doentes com risco elevado de morte e eventos cardiovasculares a curto prazo e a longo prazo com o objetivo de instituir estratégia invasiva precoce e terapêutica médica otimizada<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">2,3</span></a>. É recomendada a instituição de estratégia invasiva imediata (<<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>h) nos doentes com isquemia refratária, choque cardiogénico ou com instabilidade hemodinâmica ou elétrica e de estratégia invasiva precoce (<<span class="elsevierStyleHsp" style=""></span>24<span class="elsevierStyleHsp" style=""></span>h) em doentes com pelo menos um critério primário de alto risco (<a class="elsevierStyleCrossRef" href="#tbl0050">Tabela 10</a>). Nos doentes com <span class="elsevierStyleItalic">score</span> GRACE<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>140 e um critério secundário de alto risco (<a class="elsevierStyleCrossRef" href="#tbl0050">Tabela 10</a>) a estratégia invasiva deve ser realizada preferencialmente até às 72<span class="elsevierStyleHsp" style=""></span>h após admissão. Nos doentes de baixo risco, sem sintomas recorrentes, deve avaliar‐se a isquemia induzível de forma não‐invasiva previamente à alta. No entanto, e em conformidade com o demonstrado em meta‐análises de ensaios clínicos<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">10,11</span></a>, considera‐se que a adoção de estratégia invasiva rotineira pode ser realizada. A meta‐análise de Hoenig et al.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">10</span></a> incidiu nos ensaios <span class="elsevierStyleItalic">Treat Angina With Aggrastat and Determine the Cost of Therapy With an Invasive or Conservative Strategy</span> (TACTICS‐TIMI 18), <span class="elsevierStyleItalic">Value of first day angiography/Angioplasty In evolving Non‐ST segment elevation myocardial infarction, an Open multicenter randomized trial</span> (VINO), <span class="elsevierStyleItalic">Fragmin during Instability in Coronary Artery Disease</span> (FRISC-II), <span class="elsevierStyleItalic">Invasive versus Conservative Treatment in Unstable Coronary Syndromes</span> (ICTUS) e <span class="elsevierStyleItalic">Randomized Intervention Trial of unstable Angina-3</span> (RITA-3) e mostra que a adoção de estratégia invasiva na angina instável (AI)/EAMSST resulta numa diminuição relativa de 33% do risco nos <span class="elsevierStyleItalic">endpoints</span> de angina refratária e de reinternamento aos seis a 12 meses. Demonstra também que, apesar da estratégia invasiva estar associada a um aumento de duas vezes no risco de periprocedimento de EAM, há uma significativa diminuição de 27 e 22% de redução do risco relativo de EAM aos seis a 12 meses e de três a cinco anos, respetivamente. A meta‐análise de Fox et al.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">11</span></a> incidiu sobre os ensaios FRISC‐II, ICTUS e RITA‐3 e mostrou que a estratégia invasiva rotineira em doentes com EAMSST <span class="elsevierStyleItalic">versus</span> estratégia invasiva seletiva diminuiu a mortalidade cardiovascular ou a ocorrência de EAM ao longo de um período de cinco anos, com a diferença mais pronunciada nos doentes de alto risco. A idade, diabetes <span class="elsevierStyleItalic">mellitus</span>, EAM prévio, infradesnivelamento do segmento ST, HTA, IMC inferior a 25<span class="elsevierStyleHsp" style=""></span>kg/m<span class="elsevierStyleSup">2</span> ou superior a 35<span class="elsevierStyleHsp" style=""></span>kg/m<span class="elsevierStyleSup">2</span> e a estratégia de tratamento adotada demonstraram ser preditores independentes de morte ou EAM não‐fatal ao longo do período de seguimento clínico<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">11</span></a>. Os dados obtidos a partir de registos<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">1</span></a> mostram que a estratégia invasiva rotineira está associada à diminuição do <span class="elsevierStyleItalic">endpoint</span> combinado de morte e EAM com a diferença relativamente à estratégia conservadora a ser principalmente determinada pelo aumento da mortalidade.</p><elsevierMultimedia ident="tbl0050"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Apesar de toda esta evidência verifica‐se que a relação entre o risco do doente e a realização de estratégia invasiva é inversa<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">5,8</span></a>, situação também determinada no registo apresentado por Puymirat et al.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">1</span></a> que mostra que os doentes submetidos a estratégia invasiva eram mais novos e tinham <span class="elsevierStyleItalic">score</span> GRACE mais baixo do que os submetidos a estratégia conservadora.</p><p id="par0115" class="elsevierStylePara elsevierViewall">O presente trabalho englobou vários centros nacionais e pretendeu analisar, numa população de doentes do mundo real e com base num registo multicêntrico e com critérios de inclusão uniformes, a dimensão e o impacto da estratégia conservadora no EAMSST.</p><p id="par0120" class="elsevierStylePara elsevierViewall">Destacam‐se as diferenças já constatadas noutros registos, nomeadamente a idade média mais elevada, a maior prevalência do género feminino e de critérios de alto risco – traduzidos também nos estratos de <span class="elsevierStyleItalic">score</span> GRACE – no grupo de doentes submetido a estratégia conservadora; este também usufrui menos de terapêutica farmacológica com comprovado benefício na diminuição da morbilidade e mortalidade no contexto de SCA<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">2</span></a> pelo que também se constata o paradoxo entre o risco do doente e a estratégia adotada.</p><p id="par0125" class="elsevierStylePara elsevierViewall">A estratégia conservadora é um preditor independente de MIH e M1ano – que definem o <span class="elsevierStyleItalic">endpoint</span> primário − e de CIH que definem o <span class="elsevierStyleItalic">endpoint</span> secundário, em conformidade com outros estudos<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">1,10,11</span></a>. No entanto, constata‐se que com a estratificação pelo <span class="elsevierStyleItalic">score</span> GRACE não há diferença na MIH nos estratos de risco baixo e intermédio, o que contrasta com a evidência existente<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">2,8</span></a>; uma eventual explicação para este resultado pode residir no número reduzido de mortes verificadas nestes estratos, o que pode dificultar a deteção de diferenças que podem efetivamente existir na população de onde foi extraída a amostra estudada. Relativamente à M1ano constata‐se que é significativamente mais elevada nos estratos de risco intermédio e de risco alto. Este padrão de relação significativa com o estrato de risco intermédio e de risco alto é também verificado na ocorrência de complicações definidas pelos critérios GUSTO.</p><p id="par0130" class="elsevierStylePara elsevierViewall">Estes resultados suscitam a reflexão sobre os determinantes de não realização de estratégia invasiva nomeadamente as comorbilidades não cardíacas e uma possível não utilização adequada dos <span class="elsevierStyleItalic">scores</span> de risco isquémico.</p><p id="par0135" class="elsevierStylePara elsevierViewall">Das CIH ocorridas no internamento destaca‐se a ocorrência de reenfarte, mais frequente nos doentes submetidos a estratégia invasiva − ao contrário do descrito<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">12</span></a> − e particularmente nos doentes com vaso tratado por ICP. A definição de reenfarte utilizada neste trabalho que, por exemplo, não especifica o vaso em que ocorre o novo evento − assim como a definição de vaso tratado por ICP, que apenas considera um sucesso angiográfico imediato e não o sucesso de procedimento ou o sucesso clínico<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">13</span></a>, não permite clarificar categoricamente a sua causa, suscitando, por exemplo, a questão do papel da revascularização incompleta neste resultado.</p><p id="par0140" class="elsevierStylePara elsevierViewall">Dos outros preditores de MIH, M1ano e CIH definidoras do <span class="elsevierStyleItalic">endpoint</span> secundário destaca‐se a idade<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">14,15</span></a> que, <span class="elsevierStyleItalic">per se</span>, se associa a menor probabilidade de adoção de estratégia invasiva<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">16,17</span></a>, situação relevante devido à crescente preponderância da patologia cardiovascular numa população cada vez mais envelhecida<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">4,18</span></a>.</p><p id="par0145" class="elsevierStylePara elsevierViewall">Neste trabalho destaca‐se também a heterogeneidade dos doentes submetidos a coronariografia e não submetidos a ICP; em 21,6% destes doentes não foi identificada doença coronária angiograficamente significativa e 36,8% foram referenciados para cirurgia de pontagem aorto‐coronária pelo que se constata que 41,6% tinham doença coronária significativa, mas não foram submetidos a revascularização. Apesar da heterogeneidade existente neste grupo constata‐se que tem melhor prognóstico do que o grupo dos doentes submetidos a estratégia conservadora pelo que é realçada a importância da avaliação da anatomia coronária no estabelecimento da estratégia terapêutica a adotar.</p><p id="par0150" class="elsevierStylePara elsevierViewall">Ao contrário do descrito na literatura<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">2</span></a>, a estratégia conservadora não está associada a maior duração de internamento. Apesar de os dados não permitirem determinar o motivo, tal situação pode dever‐se ao facto do grupo 2 ter a menor percentagem de alta para o domicílio e as mais altas percentagens de transferência inter‐hospitalar, o qual poderá estar associado à maior prevalência de doentes com indicação cirúrgica. No entanto, o desenho do estudo não permite afirmar relação de causalidade.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Limitações</span><p id="par0155" class="elsevierStylePara elsevierViewall">O estudo apresenta as limitações existentes em todos os registos, pois nem todos os centros em Portugal participam no RNSCA e os participantes não incluem todos os seus doentes. Devido à limitação do formato do registo, não são explícitas as razões da não realização de estratégia invasiva, nomeadamente as preferências dos doentes ou contraindicações. Possui também as limitações existentes em todos os estudos observacionais, nomeadamente a impossibilidade de afirmação de causalidade em parâmetros que se encontram a ser correlacionados e também o facto das comparações entre as diferentes estratégias terapêuticas não terem sido definidas aleatoriamente. Por conseguinte, os resultados apenas se podem considerar como indicativos.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conclusão</span><p id="par0160" class="elsevierStylePara elsevierViewall">O presente estudo é o resultado da prática clínica do mundo real e mostra que a estratégia conservadora nos doentes com EAMSST está associada a maior ocorrência de MIH, CIH e de morte até um ano após a alta hospitalar.</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Responsabilidades éticas</span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Proteção de pessoas e animais</span><p id="par0165" class="elsevierStylePara elsevierViewall">Os autores declaram que para esta investigação não se realizaram experiências em seres humanos e/ou animais.</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Confidencialidade dos dados</span><p id="par0170" class="elsevierStylePara elsevierViewall">Os autores declaram que não aparecem dados de pacientes neste artigo.</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Direito à privacidade e consentimento escrito</span><p id="par0175" class="elsevierStylePara elsevierViewall">Os autores declaram que não aparecem dados de pacientes neste artigo.</p></span></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conflito de interesses</span><p id="par0180" class="elsevierStylePara elsevierViewall">Os autores declaram não haver conflito de interesses.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:18 [ 0 => array:3 [ "identificador" => "xres507339" "titulo" => "Resumo" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introdução e objetivo" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusões" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec528355" "titulo" => "Palavras‐chave" ] 2 => array:3 [ "identificador" => "xres507340" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introduction and Objectives" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusions" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec528356" "titulo" => "Keywords" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introdução" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "População e métodos" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Resultados" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Caracterização da população" ] ] ] 7 => array:2 [ "identificador" => "sec0025" "titulo" => "Terapêutica farmacológica realizada no internamento" ] 8 => array:2 [ "identificador" => "sec0030" "titulo" => "Terapêutica invasiva e avaliação da função ventricular esquerda" ] 9 => array:2 [ "identificador" => "sec0035" "titulo" => "Complicações, mortalidade intra‐hospitalar e destino pós‐alta hospitalar" ] 10 => array:2 [ "identificador" => "sec0040" "titulo" => "Medicação na alta hospitalar" ] 11 => array:2 [ "identificador" => "sec0045" "titulo" => "Mortalidade um ano após alta hospitalar e respetivos preditores" ] 12 => array:2 [ "identificador" => "sec0050" "titulo" => "Discussão" ] 13 => array:2 [ "identificador" => "sec0055" "titulo" => "Limitações" ] 14 => array:2 [ "identificador" => "sec0060" "titulo" => "Conclusão" ] 15 => array:3 [ "identificador" => "sec0065" "titulo" => "Responsabilidades éticas" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0070" "titulo" => "Proteção de pessoas e animais" ] 1 => array:2 [ "identificador" => "sec0075" "titulo" => "Confidencialidade dos dados" ] 2 => array:2 [ "identificador" => "sec0080" "titulo" => "Direito à privacidade e consentimento escrito" ] ] ] 16 => array:2 [ "identificador" => "sec0085" "titulo" => "Conflito de interesses" ] 17 => array:1 [ "titulo" => "Bibliografia" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-08-06" "fechaAceptado" => "2014-10-25" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras‐chave" "identificador" => "xpalclavsec528355" "palabras" => array:3 [ 0 => "Enfarte agudo do miocárdio sem supradesnivelamento de ST" 1 => "Estratégia conservadora" 2 => "Prognóstico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec528356" "palabras" => array:3 [ 0 => "Non‐ST elevation myocardial infarction" 1 => "Conservative strategy" 2 => "Prognosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:3 [ "titulo" => "Resumo" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introdução e objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Avaliar o impacto da estratégia conservadora no enfarte agudo do miocárdio sem supradesnivelamento de ST nos doentes do Registo Nacional de Síndromes Coronárias Agudas.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dos 3780 doentes incluídos no estudo durante um período de três anos, foram formados três grupos: no grupo 1 foram incluídos os submetidos a estratégia conservadora; no grupo 2 foram incluídos os doentes submetidos a coronariografia sem realização de intervenção coronária percutânea e no grupo 3 os que foram submetidos a intervenção coronária percutânea. Compararam‐se as características clínicas e de procedimento e as complicações ocorridas no internamento. O <span class="elsevierStyleItalic">endpoint</span> primário foi definido pela mortalidade intra‐hospitalar ou morte ao fim de um ano e o <span class="elsevierStyleItalic">endpoint</span> secundário foi definido pela ocorrência de pelo menos uma das seguintes complicações: hemorragia grave definida pelos critérios de GUSTO, necessidade de transfusão, ventilação invasiva, insuficiência cardíaca e reenfarte.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Dos doentes analisados, 16,5% foram submetidos a estratégia conservadora; estes eram mais velhos, mais frequentemente mulheres e apresentavam mais fatores de alto risco. A estratégia conservadora associou‐se a maior atingimento do <span class="elsevierStyleItalic">endpoint</span> primário − mortalidade intra‐hospitalar (10,6% <span class="elsevierStyleItalic">versus</span> 1,1% <span class="elsevierStyleItalic">versus</span> 0,6%, p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001, <span class="elsevierStyleItalic">odds‐ratio</span> [OR] de 6,974, intervalo de confiança a 95% [IC95%]: 2,775‐17,527), mortalidade ao ano (26,1% <span class="elsevierStyleItalic">versus</span> 6,8% <span class="elsevierStyleItalic">versus</span> 4,1%, p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001, <span class="elsevierStyleItalic">hazard‐ratio</span> (HR) 2,925, IC95%: 1,433‐5,974) − e do <span class="elsevierStyleItalic">endpoint</span> secundário − 37,2% <span class="elsevierStyleItalic">versus</span> 18,9% <span class="elsevierStyleItalic">versus</span> 14,6%, p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001; OR 1,471 IC95%: 1,043‐2,076.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusões</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Neste conjunto de doentes, a estratégia conservadora é um preditor independente de mortalidade intra‐hospitalar, complicações intra‐hospitalares e da mortalidade ao ano.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introdução e objetivo" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusões" ] ] ] "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction and Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to assess the impact of a conservative strategy in non‐ST‐segment elevation myocardial infarction in patients in the Portuguese Registry of Acute Coronary Syndromes.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0135" class="elsevierStyleSimplePara elsevierViewall">The 3780 patients included in the study over a three‐year period were divided into three groups: group 1, patients treated by a conservative strategy during hospitalization; group 2, patients who underwent coronary angiography without percutaneous coronary intervention (PCI); and group 3, patients who underwent PCI. Clinical and procedural data and in‐hospital complications were compared. The primary endpoint was defined as in‐hospital or one‐year mortality and the secondary endpoint as the presence of at least one of the following in‐hospital complications: major bleeding according to the GUSTO criteria, need for blood transfusion, invasive ventilation, heart failure or reinfarction.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0140" class="elsevierStyleSimplePara elsevierViewall">Of the patients analyzed, 16.5% were treated by a conservative strategy. Patients in this group were older, more often women, and had more high‐risk factors. A conservative strategy was associated with a higher rate of the primary endpoint – in‐hospital mortality (10.6% vs. 1.1% vs. 0.6% in groups 1, 2 and 3, respectively, p<0.001, odds ratio (OR) 6.974, 95% confidence interval [CI]: 2.775‐17.527) and one‐year mortality (26.1% vs. 6.8% vs. 4.1%, p<0.001, hazard ratio (HR) 2.925, 95% CI: 1.433 ‐5.974) ‐ and of the secondary endpoint − 37.2% vs. 18.9% vs. 14.6%, p<0.001; OR 1.471 95% CI: 1.043 ‐2.076.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0145" class="elsevierStyleSimplePara elsevierViewall">In this patient population, a conservative strategy is an independent predictor of in‐hospital mortality, in‐hospital complications and one‐year mortality.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introduction and Objectives" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusions" ] ] ] ] "multimedia" => array:12 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1572 "Ancho" => 1595 "Tamanyo" => 87527 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Curvas de Cox com a evolução da mortalidade dos grupos ao longo do período de um ano de acordo com a estratégia terapêutica utilizada.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1034 "Ancho" => 3126 "Tamanyo" => 130137 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Curvas de Kaplan‐Meier com a evolução da mortalidade dos grupos ao longo do período de um ano, de acordo com os estratos de risco do <span class="elsevierStyleItalic">score</span> GRACE.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Tabela 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">DP: desvio‐padrão.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Grupo 1(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>623) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Grupo 2(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1229) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Grupo 3(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1928) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Idade (média<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>DP) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">76,3<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>12,6 anos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">66,6<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>12,3 anos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">64,9<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>12,8 anos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Género masculino, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">355 (57) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">844 (68,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1448 (75,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Índice de massa corporal, kg/m<span class="elsevierStyleSup">2</span>‐ Mediana‐ Percentil 25‐ Percentil 75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25,823,628,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27,224,629,7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27,324,830,2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Dados clínicos na admissão \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Paragem cardíaca, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (0,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (0,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (0,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Frequência cardíaca, bpm (média<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>DP) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">83<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">79<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">77<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Pressão arterial sistólica, mmHg (média<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>DP) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">139<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">141<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">144<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Pressão arterial diastólica, mmHg (média<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>DP) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">75<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">80<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">81<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Classe Killip‐Kimball I, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">401 (64,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1006 (82,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1683 (87,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Classe Killip‐Kimball II, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">132 (21,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">140 (11,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">158 (8,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Classe Killip‐Kimball III, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">77 (12,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">75 (6,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">69 (3,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Classe Killip‐Kimball IV, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 (1,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (0,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 (0,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">ECG de apresentação</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Ritmo sinusal, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">510 (82,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1085 (88,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1793 (93,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Fibrilhação auricular, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">101 (16,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">123 (10,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">113 (5,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Infradesnivelamento de ST, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">269 (43,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">471 (38,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">635 (33,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">FRCV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Hipertensão arterial, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">504 (81,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">915 (75,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1365 (72,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Diabetes <span class="elsevierStyleItalic">mellitus</span>, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">232 (38,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">406 (33,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">600 (31,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,022 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Dislipidemia, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">339 (57,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">736 (63,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1112 (61,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,071 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Tabagismo, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">59 (9,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">259 (21,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">533 (27,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">História familiar de doença coronária, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 (4,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">70 (6,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">130 (7,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,012 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">EAM prévio, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">257 (41,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">301 (24,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">433 (22,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">ICP prévia, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">118 (19,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">165 (13,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">343 (17,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Cirurgia de pontagem aorto‐coronária prévia, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">74 (12,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">74 (6,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">91 (4,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Doença vascular periférica, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">86 (14,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">85 (7,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">90 (4,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Comorbilidades</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Insuficiência cardíaca, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">153 (24,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">105 (8,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">95 (4,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Doença pulmonar obstrutiva crónica, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52 (8,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">92 (7,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">110 (5,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,017 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Demência, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">42 (7,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 (1,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 (0,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">AVC/AIT prévio, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">101 (16,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">141 (11,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">128 (6,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">DRC, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">119 (20,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">85 (7,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">110 (5,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Dados laboratoriais \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Creatinina na admissão, mg/dl \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Mediana \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="3" align="char" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Percentil 25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Percentil 75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Creatinina máxima, mg/dl \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Mediana \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Percentil 25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Percentil 75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Glicemia, mg/dl \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Mediana \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">138 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">126 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">122 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Percentil 25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">109 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">104 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">102 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Percentil 75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">194 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">171 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">167 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Hemoglobina na admissão, g/dL (média<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>DP) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12,5<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13,5<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13,9<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1,8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Hemoglobina, valor mínimo, g/dL (média<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>DP) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11,5<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2,1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12,4<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12,6<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1,9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Plaquetas, x<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>/L \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,257 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Mediana \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">203 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">206 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">209 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Percentil 25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">169 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">168 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">175 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Percentil 75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">248 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">250 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">248 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">BNP, pg/ml \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Mediana \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">475,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">240,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">133,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Percentil 25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">199,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">105,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">64,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Percentil 75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1047,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">523,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">295,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">NT‐proBNP, pg/ml \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Mediana \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5375,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1027,5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">833,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Percentil 25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1970,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">348,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">280,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Percentil 75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12<span class="elsevierStyleHsp" style=""></span>800,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3216,5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2680,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Score</span> GRACE – estratos de risco \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Risco baixo n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">47 (8,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">248 (22,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">523 (30,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Risco intermédio n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">129 (22,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">360 (33,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">627 (36,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Risco alto n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">393 (69,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">477 (44,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">587 (33,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab810110.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Caracterização da população – variáveis clínicas, laboratoriais e <span class="elsevierStyleItalic">score</span> GRACE</p>" ] ] 3 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Tabela 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">ARA‐II: antagonista dos recetores AT<span class="elsevierStyleInf">1</span> da angiotensina <span class="elsevierStyleSmallCaps">II</span>; IECA: inibidor da enzima conversora da angiotensina.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Grupo 1(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>623) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Grupo 2(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1229) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Grupo 3(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1928) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Ácido acetilsalicílico, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">593 (95,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1208 (98,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1907 (98,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Clopidogrel, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">473 (76,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1048 (85,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1892 (98,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Heparina não‐fracionada (HNF), n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 (1,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">153 (12,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">432 (22,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Enoxaparina, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">417 (67,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">909 (74,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1359 (70,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,006 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Fondaparinux, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">138 (22,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">246 (20,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">350 (18,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,055 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Inibidores das glicoproteínas IIb/IIIa, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (1,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40 (3,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">410 (21,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Betabloqueadores, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">405 (66,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">987 (80,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1647 (85,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">IECA/ARA‐II, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">485 (79,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1076 (88,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1720 (89,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Estatina, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">571 (92,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1176 (95,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1867 (96,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Diuréticos, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">349 (57,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">400 (32,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">440 (23,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Amiodarona, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">89 (14,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">94 (7,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">114 (6,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Digoxina, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28 (4,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">34 (2,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 (1,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Inotrópicos, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">38 (6,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 (1,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24 (1,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab810102.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Terapêutica farmacológica realizada no internamento</p>" ] ] 4 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Tabela 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">CD: coronária direita; Cx: circunflexa; DA: descendente anterior; TC: tronco comum; NA: não aplicável.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Grupo 1(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>623) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Grupo 2(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1229) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Grupo 3(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1928) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Acesso vascular‐ Femoral, n (%)‐ Radial, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">334 (28,3)846 (71,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">505 (27,2)1351 (72,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0,510 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">N.° de vasos lesados,‐ Nenhum vaso, n (%)‐ Um vaso, n (%)‐ Dois vasos, n (%)‐ Três vasos, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">262 (21,6)227 (18,7)261 (21,6)461 (38,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (0,4)878 (45,8)662 (34,5)370 (19,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Artéria responsável pelo SCA‐ TC, n (%)‐ DA, n (%)‐ Cx, n (%)‐ CD, n (%)‐ Pontagem, n (%)‐ Não identificada, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">42 (4,9)169 (19,8)99 (11,6)91 (10,6)14 (1,6)440 (51,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 (1,6)607 (34,9)439 (25,3)387 (22,3)28 (1,6)250 (14,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Número de vasos tratados \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Zero (só trataram pontagem) n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 (1,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Um, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1391 (74,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Dois, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">399 (21,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Três, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">54 (2,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Utilização exclusiva de <span class="elsevierStyleItalic">stent</span> revestido por fármaco, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1173 (62,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Utilização exclusiva de <span class="elsevierStyleItalic">stent</span> metálico, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">535 (28,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Fração de ejeção ventricular esquerda</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Avaliação realizada, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">555 (90,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1175 (96,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1798 (94,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Normal ><span class="elsevierStyleHsp" style=""></span>50% n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">295 (53,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">755 (64,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1298 (72,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Ligeiramente deprimida: 40‐49% n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">114 (20,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">208 (17,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">306 (17,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Moderadamente deprimida: 30‐39% n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">94 (17,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">161 (13,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">154 (8,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Gravemente deprimida <<span class="elsevierStyleHsp" style=""></span>30% n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">45 (8,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">49 (4,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">38 (2,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Método de avaliação de fração de ejeção ventricular esquerda</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Ecocardiograma, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">518 (99,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">958 (82,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1543 (87,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Radionuclídeos, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 (0,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3 (0,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (0,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab810109.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Características da população – variáveis de procedimento e avaliação da função ventricular esquerda</p>" ] ] 5 => array:7 [ "identificador" => "tbl0020" "etiqueta" => "Tabela 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Grupo 1(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>623) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Grupo 2(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1229) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Grupo 3(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1928) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Duração do Internamento, dias \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Mediana \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Percentil 25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">‐ Percentil 75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7,0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">MIH, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">66 (10,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 (1,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 (0,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Complicações intra‐hospitalares \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Insuficiência cardíaca, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">211 (33,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">199 (16,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">219 (11,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Complicação mecânica, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 (1,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (0,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (0,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">FA de novo, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">51 (8,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">58 (4,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">64 (3,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">TV mantida, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (1,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 (1,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (0,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,330 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">BAV avançado, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (2,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 (2,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 (1,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,017 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Hemorragia <span class="elsevierStyleItalic">major</span>, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13 (2,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (1,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25 (1,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,279 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Reenfarte, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (1,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 (1,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">48 (2,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,018 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Ventilação mecânica invasiva, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 (3,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 (1,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 (1,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Ventilação mecânica não invasiva, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 (4,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 (1,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 (1,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Paragem cardíaca ressuscitada, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 (2,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 (1,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 (1,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">AVC, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (1,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (0,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 (0,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,270 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Endpoint</span> secundário \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">232 (37,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">232 (18,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">281 (14,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">MIH estratificada pelo <span class="elsevierStyleItalic">score</span> GRACE \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Risco baixo, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,000 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Risco intermédio, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (1,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (0,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (0,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,217 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Risco alto, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">56 (14,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 (2,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (1,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Ocorrência de complicações definidas pelos critérios GUSTO e estratificadas pelo <span class="elsevierStyleItalic">score</span> GRACE \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Risco baixo, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (6,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (2,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 (3,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,525 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Risco intermédio, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 (14,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">36 (10,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">44 (7,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,028 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Risco alto, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">202 (51,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">158 (33,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">191 (32,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Cirurgia de pontagem aorto‐coronária \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Realizada, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">36 (2,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (0,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Planeamento após transferência hospitalar, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (0,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">301 (24,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (0,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Planeada após alta, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">114 (9,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (0,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Destino pós‐alta \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Domicílio, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">485 (87,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">848 (70,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1867 (97,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Transferência emergente para outro hospital, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (1,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">49 (4,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (0,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Transferência não‐emergente para outro hospital, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53 (9,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">303 (25,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33 (1,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Reabilitação, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">170 (32,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">207 (1,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">386 (24,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab810107.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Morte intra‐hospitalar, complicações intra‐hospitalares e destino pós‐alta</p>" ] ] 6 => array:7 [ "identificador" => "tbl0025" "etiqueta" => "Tabela 5" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">p: valor do teste Hosmer‐Lemeshow 0,271; área sob a curva ROC (IC a 95%): 0,960 (0,939‐0,982); sensibilidade do modelo 93,9%; especificidade do modelo 87,9%.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Preditores \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Beta \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">OR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Intervalo de confiança de 95% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Estratégia conservadora<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,942 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6,974 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2,775‐17,527 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Idade<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,056 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,057 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,021‐1,095 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Infradesnivelamento de ST no ECG de admissão \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,072 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2,920 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,495‐5,704 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">FEVE <<span class="elsevierStyleHsp" style=""></span>30% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,959 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7,091 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3,030‐16,593 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Paragem cardíaca ressuscitada \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2,337 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10,345 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3,389‐31,579 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">IC congestiva \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,919 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6,817 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3,005‐15,464 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Hemorragia <span class="elsevierStyleItalic">major</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2,205 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9,704 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3,044‐27,051 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">AVC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,668 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5,302 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,065‐26,406 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,042 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Utilização de inotrópicos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2,153 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8,612 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3,590‐20,658 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab810106.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Valor do OR em que se considera a classe de referência os doentes submetidos a coronariografia e ICP.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Valor do OR para o aumento de um ano de idade. Para aumentos de cinco anos de idade OR (IC 95%)<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,321 (1,111‐1,572).</p>" ] ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Preditores de mortalidade intra‐hospitalar</p>" ] ] 7 => array:7 [ "identificador" => "tbl0030" "etiqueta" => "Tabela 6" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">P: valor do teste Hosmer‐Lemeshow 0,169; área sob a curva ROC (IC a 95%): 0,899 (0,885‐0,912); sensibilidade do modelo 82,0%; especificidade do modelo 83,9%.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Preditores \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Beta \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">OR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Intervalo de confiança de 95% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Estratégia conservadora<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,386 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,471 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,043‐2,076 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,028 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Idade<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,026 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,026 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,014‐1,038 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Infradesnivelamento de ST no ECG de admissão \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,506 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,659 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,297‐2,122 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">FEVE <<span class="elsevierStyleHsp" style=""></span>30% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,965 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2,626 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,550‐4,450 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Classe Killip‐Kimball II<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">c</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,567 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4,791 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3,520‐6,520 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Classe Killip‐Kimball III<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">c</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2,135 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8,453 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5,525‐12,935 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Classe Killip‐Kimball IV<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">c</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2,449 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11,572 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2,235‐59,907 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Doença vascular periférica \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,580 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,786 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,206‐2,646 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,004 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Hemoglobina na admissão<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">d</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0,121 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,129 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1,056‐1,208 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab810108.png" ] ] ] "notaPie" => array:4 [ 0 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Valor do OR em que se considera a classe de referência os doentes submetidos a coronariografia e ICP.</p>" ] 1 => array:3 [ "identificador" => "tblfn0020" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Valor do OR para o aumento de um ano de idade. Para aumentos de cinco anos de idade OR (IC 95%)<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,138 (1,072‐1,208).</p>" ] 2 => array:3 [ "identificador" => "tblfn0025" "etiqueta" => "c" "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Valor do OR em que se considera a classe de referência Killip‐Kimball I<span class="elsevierStyleSmallCaps">.</span></p>" ] 3 => array:3 [ "identificador" => "tblfn0030" "etiqueta" => "d" "nota" => "<p class="elsevierStyleNotepara" id="npar0030">Valor do OR para o redução de uma unidade de Hb. Para redução de duas unidades de Hb OR (IC 95%)<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,275 (1,115‐1,458).</p>" ] ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Preditores de complicações intra‐hospitalares</p>" ] ] 8 => array:7 [ "identificador" => "tbl0035" "etiqueta" => "Tabela 7" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="" valign="top" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Grupo 1(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>623) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Grupo 2(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1229) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Grupo 3(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1928) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Ácido acetilsalicílico, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">457 (86,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">909 (86,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1840 (97,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Clopidogrel, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">343 (65,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">598 (57,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1830 (97,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Ácido acetilsalicílico e clopidogrel, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">320 (61,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">577 (55,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1804 (95,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Antagonistas da vitamina K, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">35 (6,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">91 (8,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">75 (4,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Betabloqueadores, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">350 (66,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">784 (75,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1569 (83,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Ivabradina, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50 (9,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">56 (5,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">62 (3,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">IECA/ARA‐II, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">404 (77,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">856 (81,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1674 (88,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Estatina, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">476 (90,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">954 (90,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1825 (96,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Diuréticos, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">269 (51,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">321 (31,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">415 (22,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Antagonistas da aldosterona, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">62 (11,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">111 (10,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">104 (5,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Amiodarona, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">43 (8,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">54 (5,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">59 (3,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Digoxina, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 (2,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 (1,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (0,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab810101.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Terapêutica farmacológica prescrita na alta hospitalar</p>" ] ] 9 => array:7 [ "identificador" => "tbl0040" "etiqueta" => "Tabela 8" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="" valign="top" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Grupo 1(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>115) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Grupo 2(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>222) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Grupo 3(n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>414) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">M1ano, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">30 (26,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">14 (6,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">17 (4,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Preditores \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Beta \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">HR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">IC95% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Estratégia conservadora<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1,073 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2,925 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1,433‐5,974 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0,003 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Idade<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0,056 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1,058 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1,024‐1,092 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Infradesnivelamento de ST no ECG de admissão \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1,376 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3,958 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2,061‐7,601 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Hemoglobina (valor mínimo)<a class="elsevierStyleCrossRef" href="#tblfn0045"><span class="elsevierStyleSup">c</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0,224 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1,251 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1,054‐1,484 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0,01 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">FEVE <<span class="elsevierStyleHsp" style=""></span>50% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0,910 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2,483 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1,333‐4,626 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0,004 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">TV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1,858 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6,409 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1,365‐30,094 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0,019 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">AVC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2,287 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">9,842 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2,189‐44,244 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0,003 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab810105.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0035" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0035">Valor do HR em que se considera a classe de referência os doentes submetidos a coronariografia e ICP.</p>" ] 1 => array:3 [ "identificador" => "tblfn0040" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0040">Valor do HR para o aumento de um ano de idade. Para aumentos de cinco anos de idade HR (IC 95%)<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,324 (1,126‐1,556).</p>" ] 2 => array:3 [ "identificador" => "tblfn0045" "etiqueta" => "c" "nota" => "<p class="elsevierStyleNotepara" id="npar0045">Valor do HR para o redução de uma unidade de Hb. Para redução de duas unidades de Hb HR(IC 95%)<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,565 (1,111‐2,203).</p>" ] ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">Mortalidade ao ano após alta hospitalar e respetivos preditores</p>" ] ] 10 => array:7 [ "identificador" => "tbl0045" "etiqueta" => "Tabela 9" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="" valign="top" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Grupo 1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Grupo 2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">Grupo 3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Risco baixo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(0/9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(2/61) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(1/106) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0,489 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Risco intermédio \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(1/23) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(0/50) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(0/136) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0,024 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Risco alto \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(25/74) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(11/95) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(16/153) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(N.° eventos / N.° total) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(N.° eventos / N.° total) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(N.° eventos / N.° total) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab810104.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">Mortalidade ao ano estratificada pelo <span class="elsevierStyleItalic">score</span> GRACE</p>" ] ] 11 => array:7 [ "identificador" => "tbl0050" "etiqueta" => "Tabela 10" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0130" class="elsevierStyleSimplePara elsevierViewall">TFG: taxa de filtração glomerular.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Critérios primários</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>1. Elevação ou diminuição relevante da troponina \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>2. Alterações dinâmicas do segmento ST ou da onda T (sintomáticas ou assintomáticas) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>3. <span class="elsevierStyleItalic">Score</span> GRACE ><span class="elsevierStyleHsp" style=""></span>140 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Critérios secundários</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>4. Diabetes <span class="elsevierStyleItalic">mellitus</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>5. Doença renal crónica (TFG <<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>mL/min/1,73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>6. FEVE <<span class="elsevierStyleHsp" style=""></span>40% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>7. Angina pós‐enfarte precoce \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>8. ICP recente \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>9. Pontagem aorto‐coronária prévia \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>10. <span class="elsevierStyleItalic">Score</span> GRACE intermédio a alto \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab810103.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">Critérios de alto risco com indicação de estratégia invasiva (Adaptado de: Windecker et al.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">3</span></a>)</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib0095" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of invasive strategy in non‐ST‐segment elevation myocardial infarction is a major determinant of improved long‐term survival: FAST‐MI (French Registry of Acute Coronary Syndrome)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E. 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| Ano/Mês | Html | Total | |
|---|---|---|---|
| 2024 Novembro | 9 | 4 | 13 |
| 2024 Outubro | 51 | 34 | 85 |
| 2024 Setembro | 60 | 26 | 86 |
| 2024 Agosto | 47 | 21 | 68 |
| 2024 Julho | 45 | 27 | 72 |
| 2024 Junho | 43 | 16 | 59 |
| 2024 Maio | 54 | 22 | 76 |
| 2024 Abril | 54 | 22 | 76 |
| 2024 Maro | 50 | 20 | 70 |
| 2024 Fevereiro | 32 | 28 | 60 |
| 2024 Janeiro | 38 | 22 | 60 |
| 2023 Dezembro | 36 | 24 | 60 |
| 2023 Novembro | 42 | 26 | 68 |
| 2023 Outubro | 24 | 12 | 36 |
| 2023 Setembro | 34 | 24 | 58 |
| 2023 Agosto | 24 | 14 | 38 |
| 2023 Julho | 20 | 6 | 26 |
| 2023 Junho | 38 | 11 | 49 |
| 2023 Maio | 44 | 20 | 64 |
| 2023 Abril | 16 | 4 | 20 |
| 2023 Maro | 27 | 19 | 46 |
| 2023 Fevereiro | 30 | 17 | 47 |
| 2023 Janeiro | 21 | 12 | 33 |
| 2022 Dezembro | 26 | 21 | 47 |
| 2022 Novembro | 40 | 22 | 62 |
| 2022 Outubro | 28 | 29 | 57 |
| 2022 Setembro | 29 | 23 | 52 |
| 2022 Agosto | 33 | 28 | 61 |
| 2022 Julho | 35 | 45 | 80 |
| 2022 Junho | 19 | 21 | 40 |
| 2022 Maio | 24 | 34 | 58 |
| 2022 Abril | 33 | 26 | 59 |
| 2022 Maro | 32 | 33 | 65 |
| 2022 Fevereiro | 31 | 28 | 59 |
| 2022 Janeiro | 24 | 24 | 48 |
| 2021 Dezembro | 25 | 33 | 58 |
| 2021 Novembro | 45 | 32 | 77 |
| 2021 Outubro | 85 | 28 | 113 |
| 2021 Setembro | 53 | 21 | 74 |
| 2021 Agosto | 19 | 16 | 35 |
| 2021 Julho | 21 | 29 | 50 |
| 2021 Junho | 24 | 20 | 44 |
| 2021 Maio | 32 | 25 | 57 |
| 2021 Abril | 49 | 25 | 74 |
| 2021 Maro | 35 | 17 | 52 |
| 2021 Fevereiro | 42 | 16 | 58 |
| 2021 Janeiro | 27 | 11 | 38 |
| 2020 Dezembro | 21 | 14 | 35 |
| 2020 Novembro | 23 | 9 | 32 |
| 2020 Outubro | 25 | 10 | 35 |
| 2020 Setembro | 22 | 10 | 32 |
| 2020 Agosto | 18 | 5 | 23 |
| 2020 Julho | 32 | 5 | 37 |
| 2020 Junho | 25 | 9 | 34 |
| 2020 Maio | 22 | 1 | 23 |
| 2020 Abril | 34 | 11 | 45 |
| 2020 Maro | 34 | 12 | 46 |
| 2020 Fevereiro | 88 | 33 | 121 |
| 2020 Janeiro | 26 | 9 | 35 |
| 2019 Dezembro | 24 | 5 | 29 |
| 2019 Novembro | 22 | 5 | 27 |
| 2019 Outubro | 27 | 11 | 38 |
| 2019 Setembro | 17 | 9 | 26 |
| 2019 Agosto | 29 | 9 | 38 |
| 2019 Julho | 32 | 9 | 41 |
| 2019 Junho | 31 | 26 | 57 |
| 2019 Maio | 44 | 16 | 60 |
| 2019 Abril | 25 | 10 | 35 |
| 2019 Maro | 18 | 10 | 28 |
| 2019 Fevereiro | 23 | 14 | 37 |
| 2019 Janeiro | 16 | 8 | 24 |
| 2018 Dezembro | 37 | 15 | 52 |
| 2018 Novembro | 128 | 14 | 142 |
| 2018 Outubro | 247 | 12 | 259 |
| 2018 Setembro | 44 | 10 | 54 |
| 2018 Agosto | 26 | 14 | 40 |
| 2018 Julho | 36 | 12 | 48 |
| 2018 Junho | 59 | 14 | 73 |
| 2018 Maio | 74 | 13 | 87 |
| 2018 Abril | 91 | 19 | 110 |
| 2018 Maro | 112 | 8 | 120 |
| 2018 Fevereiro | 55 | 7 | 62 |
| 2018 Janeiro | 98 | 9 | 107 |
| 2017 Dezembro | 96 | 10 | 106 |
| 2017 Novembro | 49 | 20 | 69 |
| 2017 Outubro | 46 | 11 | 57 |
| 2017 Setembro | 54 | 11 | 65 |
| 2017 Agosto | 37 | 14 | 51 |
| 2017 Julho | 30 | 14 | 44 |
| 2017 Junho | 50 | 16 | 66 |
| 2017 Maio | 38 | 14 | 52 |
| 2017 Abril | 21 | 13 | 34 |
| 2017 Maro | 30 | 10 | 40 |
| 2017 Fevereiro | 28 | 8 | 36 |
| 2017 Janeiro | 44 | 9 | 53 |
| 2016 Dezembro | 31 | 16 | 47 |
| 2016 Novembro | 29 | 8 | 37 |
| 2016 Outubro | 24 | 9 | 33 |
| 2016 Setembro | 27 | 5 | 32 |
| 2016 Agosto | 15 | 4 | 19 |
| 2016 Julho | 12 | 6 | 18 |
| 2016 Junho | 3 | 0 | 3 |
| 2016 Maio | 2 | 7 | 9 |
| 2016 Abril | 32 | 3 | 35 |
| 2016 Maro | 48 | 7 | 55 |
| 2016 Fevereiro | 74 | 15 | 89 |
| 2016 Janeiro | 53 | 18 | 71 |
| 2015 Dezembro | 35 | 9 | 44 |
| 2015 Novembro | 30 | 11 | 41 |
| 2015 Outubro | 35 | 12 | 47 |
| 2015 Setembro | 29 | 14 | 43 |
| 2015 Agosto | 39 | 14 | 53 |
| 2015 Julho | 44 | 26 | 70 |
| 2015 Junho | 89 | 30 | 119 |
| 2015 Maio | 99 | 71 | 170 |
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