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A trombectomia aspirativa na reperfusão do enfarte agudo de miocárdio: preditores e impacto clínico da sua ineficácia
Thrombus aspiration for reperfusion in myocardial infarction: Predictors and clinical impact of ineffectiveness
André Luz
, Patrícia Rodrigues, Maria João Sousa, Inês Silveira, Diana Anjo, Bruno Brochado, Mário Santos, João Silveira, Henrique Cyrne Carvalho, Severo Torres
Autor para correspondência
Serviço de Cardiologia, Centro Hospitalar do Porto, E.P.E., Porto, Portugal
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A vantagem da TbA durante a intervenção coronária percutânea primária (ICPP) reside na aspiração do trombo coronário por forma a reduzir a embolização distal de material trombótico durante a angioplastia. Com isto pretende‐se melhorar a microperfusão coronária e, consequentemente, reduzir a área total de enfarte<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–6</span></a>. Comparativamente aos dispositivos de aspiração mecânica, a TbA manual é mais simples de utilizar e de igual ou superior eficácia<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7–9</span></a>.</p><p id="par0075" class="elsevierStylePara elsevierViewall">A introdução da TbA manual revestiu‐se de grande entusiasmo e popularidade na área da cardiologia de intervenção, tendo‐lhe sido atribuída classe <span class="elsevierStyleSmallCaps">II</span>a/B nas recomendações europeias para o tratamento do EAMST<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>. Contudo, assiste‐se a grande variabilidade na utilização desta técnica como adjuvante na reperfusão<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>. Num registo recente, a TbA manual não atingiu 20% das ICPP nos Estados Unidos da América (EUA)<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>. Apesar de alguns estudos aleatorizados demonstrarem benefícios clínicos ao reduzir eventos cardiovasculares <span class="elsevierStyleItalic">major</span><a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13–15</span></a>, que foram posteriormente reafirmados em meta‐análises<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,16–18</span></a>, algumas séries (onde se inclui uma de grande dimensão) não têm confirmada a mesma eficácia clínica<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19–22</span></a>. No entanto, nalguns casos, a TbA pode ser difícil de utilizar (10% dos doentes alocados para TbA no estudo TAPAS<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>). Assim, o efeito que a ineficácia da aspiração do trombo possa ter em doentes onde a TbA fora considerada, <span class="elsevierStyleItalic">a priori</span>, necessária, tem sido pouco explorado.</p><p id="par0080" class="elsevierStylePara elsevierViewall">O objetivo principal deste trabalho foi conhecer os preditores da ineficácia da TbA durante a ICPP numa série consecutiva de doentes com EAM orientados para ICPP, onde a TbA tenha sido sistematicamente utilizada e como primeira intenção (excluem‐se situações de <span class="elsevierStyleItalic">bail out</span>). Como objetivo secundário, conhecer os preditores de mortalidade cumulativa (cardíaca e não cardíaca) no médio prazo pós‐EAMST.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Métodos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">População estudada e definições</span><p id="par0085" class="elsevierStylePara elsevierViewall">Série retrospetiva de um centro, consecutiva, de doentes com EAMST admitidos para ICPP entre janeiro de 2008 e dezembro de 2013. Excluíram‐se doentes com <span class="elsevierStyleItalic">bypass</span> aorto‐coronário. As variáveis clínicas, laboratoriais e relacionadas com o procedimento desde a admissão até à alta hospitalar foram compiladas através da consulta da base eletrónica de dados hospitalar. O estado vital do doente em seguimento foi avaliado pela consulta do processo clínico eletrónico, através do contacto com o médico assistente, do doente ou familiares. O diagnóstico de EAMST baseou‐se em critérios clínicos, suportados pelas seguintes alterações no eletrocardiograma: elevação de segmento ST ≥<span class="elsevierStyleHsp" style=""></span>0,15<span class="elsevierStyleHsp" style=""></span>mV em V2‐V3 ou ≥<span class="elsevierStyleHsp" style=""></span>0,1<span class="elsevierStyleHsp" style=""></span>mV nas outras em pelo menos duas das outras derivações, depressão de ST em V2‐V3 ≥<span class="elsevierStyleHsp" style=""></span>0,15<span class="elsevierStyleHsp" style=""></span>mm com onda T positiva (enfarte posterior) ou bloqueio completo de ramo esquerdo <span class="elsevierStyleItalic">de novo</span>. Para este estudo, foram apenas considerados os doentes com artéria coronária epicárdica com imagem de trombo e fluxo <span class="elsevierStyleItalic">Thrombolysis in Myocardial Infarction</span> (TIMI) 0 ou 1, onde foi utilizada a TbA manual.</p><p id="par0090" class="elsevierStylePara elsevierViewall">O fenómeno de <span class="elsevierStyleItalic">no‐reflow</span> foi considerado se após a angioplastia não se obtivesse fluxo coronário distal TIMI ≥<span class="elsevierStyleHsp" style=""></span>2 ou fluxo TIMI 2‐3, mas com impossibilidade de o contraste perfundir território capilar miocárdico (grau de perfusão miocárdica<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0), ou se após a perfusão houvesse estagnação de contraste (grau de perfusão miocárdica<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1), na ausência de espasmo, dissecção, ou de trombo coronário epicárdico, que persistissem após administração intracoronária de nitroglicerina e adenosina. Depois da utilização do dispositivo de aspiração manual e antes de prosseguir com a angioplastia (balão e/ou <span class="elsevierStyleItalic">stent</span>), a TbA foi considerada ineficaz (TbANE) se se obtivesse fluxo coronário TIMI<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>2 e eficaz (TbAE) se fluxo TIMI 2‐3.</p><p id="par0095" class="elsevierStylePara elsevierViewall">O tempo isquémico total (TIT) foi o tempo decorrido desde o início das queixas do doente (altura em que as queixas se tornaram intensas e persistentes) até à passagem do fio guia durante a ICPP. A <span class="elsevierStyleItalic">clearance</span> da creatinina (ClCreat) foi calculada através da fórmula de <span class="elsevierStyleItalic">Cockroft‐Gault</span>.</p><p id="par0100" class="elsevierStylePara elsevierViewall">A estratificação do risco através dos <span class="elsevierStyleItalic">scores</span> Global Registry of Acute Coronary Events (GRACE)<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">23</span></a> (pontuação para mortalidade hospitalar/seis meses) e TIMI (para EAMST)<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> foi determinada para todos os doentes. A classificação anatómica através do <span class="elsevierStyleItalic">score Synergy between PCI with TAXUS drug‐eluting stent and cardiac surgery (SYNTAX)</span><a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> v 2.11 foi realizada com ajuda do sítio web, considerando‐se todas as lesões com estenoses<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>50% em vasos de calibre<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>1,5<span class="elsevierStyleHsp" style=""></span>mm. A oclusão da artéria responsável pelo enfarte foi classificada como oclusão com menos de três meses. A área miocárdica em risco foi calculada através do <span class="elsevierStyleItalic">score Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) modificado</span><a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a>. Resumidamente, este <span class="elsevierStyleItalic">score</span> angiográfico permite estimar a percentagem de miocárdio que é nutrida por um segmento coronário, tendo em atenção a dominância e o calibre dos vasos que dele provêm. É uma classificação simples de implementar e com boa correlação com a área em risco avaliada por ressonância magnética cardíaca (RMC)<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27,28</span></a>. Tomando como exemplo a artéria descendente anterior proximal, a área em risco estimada é de 47,75% na presença de importante vaso diagonal a jusante da oclusão e de 41,25% se a diagonal for pequena ou inexistente. Toda a análise angiográfica foi realizada por dois cardiologistas seniores de intervenção. Em caso de dúvida, os <span class="elsevierStyleItalic">scores</span> foram atribuídos por consenso ou pela média das observações individuais.</p><p id="par0105" class="elsevierStylePara elsevierViewall">A fração de ejeção do ventrículo esquerdo (FEVE) foi calculada por ecocardiografia 2‐D (Phillips iE33, Eindhoven, Holanda) pelo método de Simpson. A FEVE foi considerada como preservada se valores ≥<span class="elsevierStyleHsp" style=""></span>55%, depressão ligeira entre valores ≥<span class="elsevierStyleHsp" style=""></span>45% e<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>55%, depressão moderada entre ≥<span class="elsevierStyleHsp" style=""></span>30% e<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>45%, depressão severa se<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>30%. Para efeitos de análise estatística, dicotomizou‐se a FEVE em dois grupos: FVE preservada/disfunção ligeira e disfunção moderada/severa.</p><p id="par0110" class="elsevierStylePara elsevierViewall">Consideramos a mortalidade cumulativa global (cardíaca e não cardíaca, hospitalar e no seguimento) como evento cardiovascular <span class="elsevierStyleItalic">major</span>. Nesta análise, apenas foram considerados doentes com tempo mínimo de seguimento superior ou igual a 12 meses após o EAMST.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Procedimento e medicação</span><p id="par0115" class="elsevierStylePara elsevierViewall">Todos os doentes foram medicados com aspirina 300<span class="elsevierStyleHsp" style=""></span>mg e clopidogrel 600<span class="elsevierStyleHsp" style=""></span>mg antes da ICPP, a não ser que já se encontrassem sob essa medicação. O calibre do introdutor arterial foi seis ou sete French. Durante o procedimento, foi administrada heparina não fracionada (70<span class="elsevierStyleHsp" style=""></span>UI/kg). A utilização de inibidores da glicoproteína 2b/3a, tipo de <span class="elsevierStyleItalic">stent</span>, e outros dispositivos adjuvantes na angioplastia foram deixados ao critério do operador. A TbA manual foi exclusivamente efetuada pelo cateter de aspiração de trombos Export 6<span class="elsevierStyleHsp" style=""></span>F (Medtronic, Minneapolis, MN, EUA). Após a ICPP, os doentes foram admitidos em unidades de cuidados coronários. Procedeu‐se à colheita de marcadores de necrose miocárdica (troponina T [TnT], creatina kinase (CK) e CK‐massa) às seis, 12, 24 e 48<span class="elsevierStyleHsp" style=""></span>h após reperfusão. No momento da alta hospitalar, aspirina 100<span class="elsevierStyleHsp" style=""></span>mg/dia e clopidogrel 75<span class="elsevierStyleHsp" style=""></span>mg/dia foram prescritos a todos os doentes, além da medicação considerada apropriada segundo as recomendações.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Análise estatística</span><p id="par0120" class="elsevierStylePara elsevierViewall">Utilizou‐se o teste de Kolmogorov‐Smirnov para testar a distribuição da normalidade das variáveis contínuas, que foram expressas em média<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>desvio padrão (SD) ou intervalo interquartil (IQR), respetivamente, para variáveis de distribuição normal ou não normal. Variáveis contínuas de distribuição normal foram comparadas pelo teste t‐Student para amostras independentes, variáveis contínuas de distribuição não normal foram comparadas pelo teste Mann‐Whitney. As variáveis categóricas foram expressas em número e percentagens e comparadas pelo teste do qui‐quadrado ou pelo teste exato de Fisher. Os picos de TnT, de CK e CK‐massa foram transformados em logaritmo para permitir testes paramétricos. Para identificar preditores de TbANE utilizou‐se um modelo de regressão logística com a TbANE como variável dependente. As variáveis com p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,1 na análise univariada, foram incluídas na análise multivariada a fim de identificar os preditores independentes. A mortalidade não ajustada associada à eficácia da TbA foi calculada através do método de Kaplan‐Meyer, sendo a diferença obtida através do teste Log‐Rank. A mortalidade cumulativa ajustada para variáveis confundidoras foi avaliada por um modelo de Cox. Variáveis com valor de p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,1 na análise univariada foram incluídas na análise multivariada. Para evitar sobreajustamento, os <span class="elsevierStyleItalic">scores</span> GRACE e TIMI não foram incluídos nas regressões. Todos os testes foram considerados significativos se valor de p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,05 para duas caudas. A análise estatística foi efetuada em SPSS v.20 (SPSS, Chicago, IL, EUA).</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Resultados</span><p id="par0125" class="elsevierStylePara elsevierViewall">Dentre 614 doentes com EAMST, excluíram‐se 40 por informação insuficiente. Dos 574 doentes estudados, a TbA foi utilizada em 417 doentes (72,6%), considerando‐se eficaz em 365 (87,5%) e ineficaz em 52 (12,5%). No grupo TbANE, em quatro casos (4/52<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>7,7%) a TbA foi ineficaz por impossibilidade de ultrapassar a lesão. O operador procedeu à dilatação da lesão com balão e apenas num caso a TbA foi novamente utilizada, igualmente sem sucesso. As <a class="elsevierStyleCrossRefs" href="#tbl0005">Tabelas 1 e 2</a> resumem as características clínicas e as relacionadas com o procedimento, consoante a eficácia da TbA. Em geral, a TbANE esteve significativamente associada a não fumadores, <span class="elsevierStyleItalic">scores</span> GRACE, SYNTAX e classe Killip na admissão mais elevados, e TIT mais longo. Relativamente ao procedimento, encontraram‐se diferenças da artéria responsável pelo enfarte (a circunflexa menos prevalente no grupo TbANE) e colocação mais frequente de balão intra‐aórtico (BIA) no grupo TbANE. Encontrou‐se uma tendência para maior taxa de pré‐medicação com nitratos e bloqueadores da entrada do cálcio no grupo TbANE, e menor concentração de hemoglobina na admissão. Relativamente aos resultados na fase hospitalar (<a class="elsevierStyleCrossRef" href="#tbl0015">Tabela 3</a>), a taxa de fenómeno de <span class="elsevierStyleItalic">no‐reflow</span> foi mais elevada no grupo TbANE. Não se encontraram diferenças significativas nos picos enzimáticos nem nas diferenças de FEVE antes da alta hospitalar, ressalvando‐se que em 21 (3,7%) doentes não foi possível obter pico enzimático nas primeiras 24<span class="elsevierStyleHsp" style=""></span>h, em que a principal causa foi o falecimento precoce após o procedimento (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>19 [90,5%]). Nos 21 doentes, utilizou‐se a TbA em 12 (57,1%), que foi eficaz em 7 (58,3%) e ineficaz em 5 (41,7%). A duração do internamento no grupo TbANE foi mais longa. A taxa de mortalidade foi nominalmente mais elevada (13,5 <span class="elsevierStyleItalic">versus</span> 6%, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,073) no grupo TbANE, mas sem atingir significado estatístico.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">Na análise univariada, a idade, o <span class="elsevierStyleItalic">score</span> SYNTAX, o tabagismo ativo, a concentração de hemoglobina na admissão, a medicação prévia com nitratos ou bloqueadores da entrada de cálcio, o TIT e a classe 3 ou 4 de Killip na admissão correlacionaram‐se com a TbANE. Na análise multivariada, apenas o <span class="elsevierStyleItalic">score</span> SYNTAX (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,049, 95% CI: 1,015‐1,084, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,005) e o TIT (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,001, 95% CI: 1,000‐1,003, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,02) se mantiveram como preditores independentes.</p><p id="par0135" class="elsevierStylePara elsevierViewall">Identificamos 331 doentes com pelo menos 12 meses de seguimento desde o EAMST. Em dois (0,6%) doentes não foi possível obter o estado vital. Foi então possível estudar 329 doentes incluídos na análise de mortalidade a médio prazo (média<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>24<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0,82 meses, taxa de mortalidade cumulativa<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>13,9%). A mortalidade cumulativa não ajustada foi mais elevada nos doentes onde a trombectomia foi não eficaz (<a class="elsevierStyleCrossRef" href="#fig0005">Figura 1</a>). Após ajustamento para covariáveis com p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,1 na análise univariada (género, idade, eficácia da trombectomia, <span class="elsevierStyleItalic">scores</span> APPROACH e SYNTAX, fumo ativo, TIT, ClCreat, vaso alvo, colocação de BIA, hemoglobinemia, tensão arterial sistólica e classe Killip 3‐4 na admissão e FEVE no momento da alta), a FEVE com disfunção moderada/severa (HR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>6,256, 95% CI: 1,896‐20,644, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,003), o <span class="elsevierStyleItalic">score</span> APPROACH (HR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,094, 95% CI: 1,016‐1,177, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,017), e a classe 3‐4 de Killip (HR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2,953, 95% CI: 1,122‐7,770, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,028) correlacionaram‐se de forma positiva com a mortalidade, enquanto valores crescentes da ClCreat tiveram efeito protetor (HR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,973, 95% CI: 0.953‐0,994, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,011).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Discussão</span><p id="par0140" class="elsevierStylePara elsevierViewall">Nesta série, a TbA foi utilizada como primeira intenção na maioria (72,6%) dos doentes, tendo sido eficaz na grande maioria dos casos (87,5%). Parece‐nos razoável que quanto mais organizado se encontrar o trombo, menor será a eficácia da TbA, não surpreendendo que quanto maior for o atraso desde o início dos sintomas até à reperfusão, menor será a eficácia da TbA. Neste particular, a relação entre o TIT e a organização do trombo como preditores de eventos adversos fora já anteriormente descrita<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">29–32</span></a>. Desconhecíamos, contudo, a relação entre o <span class="elsevierStyleItalic">score</span> SYNTAX e a TbANE. Supõe‐se que em condições anatómicas mais desfavoráveis a técnica de aspiração fique comprometida, por exemplo, devido a tortuosidades ou calcificação, ou mesmo devido à maior quantidade de placa com risco de embolização distal e consequente microperfusão inadequada. Nalgumas séries de doentes submetidos a ICPP já se demonstrou a relação entre o <span class="elsevierStyleItalic">score</span> SYNTAX e o risco de <span class="elsevierStyleItalic">no‐reflow</span><a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a>.</p><p id="par0145" class="elsevierStylePara elsevierViewall">Tendo excluído da análise os doentes em que a TbA não fora utilizada, porventura em vasos de menor calibre ou com menor quantidade de trombo em que se previa menor vantagem da TbA, a utilização desta técnica de forma sistemática perspetivaria menor área de enfarte se fosse eficaz. Esse pressuposto não se confirmou nesta série de doentes. Sendo certo que o pico enzimático pode apenas estimar a extensão do enfarte, sabe‐se que a correlação entre os picos enzimáticos e a área de enfarte avaliada por RMC tem sido muito razoável<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">34,35</span></a>. Nalgumas séries onde a RMC foi utilizada para avaliar a área de necrose, os doentes submetidos a TbA não tiverem menor extensão do enfarte<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22,36</span></a>, mesmo nos casos onde se demonstrou ser menor a obstrução microvascular<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>.</p><p id="par0150" class="elsevierStylePara elsevierViewall">Em termos de mortalidade, não seria de esperar grande diferença face à dimensão reduzida da amostra para avaliar <span class="elsevierStyleItalic">endpoints</span> clínicos. Contudo, a tendência verificada na mortalidade hospitalar poderá tornar‐se mais evidente em séries de dimensão mais robusta. No subgrupo avaliado para a mortalidade cumulativa, e sem surpresa, a FEVE moderada/severa e a classe Killip 3‐4 foram fortes preditores independentes para a mortalidade a médio prazo. Estas duas características<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">37–39</span></a>, a par da área miocárdica em risco<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a>, têm sido referenciadas como marcadores de prognóstico adverso. Facto interessante é que o impacto da TbA pode ser significativo apenas em doentes com maior área em risco<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a>, mas faltam estudos prospetivos dirigidos para confirmar esta hipótese. A insuficiência renal tem sido várias vezes apontada como causa independente de mortalidade no doente com EAMST<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">42,43</span></a>. É pois de esperar que valores mais elevados de ClCreat se associem a efeito protetor.</p><p id="par0155" class="elsevierStylePara elsevierViewall">A discussão em torno da TbA na reperfusão está longe de chegar a consenso<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a>. A divergência encontrada nas publicações até à data poderá dever‐se a séries de dimensão modesta para avaliação de <span class="elsevierStyleItalic">endpoints</span> clínicos e a metodologias distintas para avaliar a microperfusão coronária. Por outro lado, parece que nem todos os doentes beneficiam da mesma forma da TbA, o que espelha bem a heterogeneidade dos doentes com EAMST. Relativamente aos <span class="elsevierStyleItalic">endpoints</span> clínicos mais importantes, apenas em séries de grande dimensão ou em meta‐análises se poderão encontrar respostas sólidas, pelo que os nossos resultados referentes à mortalidade devem ser interpretados com cautela. É sabido que doentes com fenómeno de <span class="elsevierStyleItalic">no‐reflow</span> têm taxas acrescidas de mortalidade a longo prazo<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a>. A relação significativa encontrada entre o <span class="elsevierStyleItalic">no‐reflow</span> e a TbANE poderá traduzir‐se em mortalidade cumulativa acrescida em séries de maior dimensão, que permitam estudar esta relação com maior detalhe. Na globalidade, os resultados deste estudo observacional aproximam‐se das últimas séries em que a TbA é comparada com a ICPP convencional. Com exceção da menor taxa de <span class="elsevierStyleItalic">no‐reflow</span>, a TbAE não se traduziu num benefício inequívoco face à TbANE.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Limitações</span><p id="par0160" class="elsevierStylePara elsevierViewall">Algumas limitações devem ser consideradas: trata‐se de estudo unicêntrico e retrospetivo, com número modesto de doentes para avaliar impacto na mortalidade a médio prazo. A taxa de ineficácia da TbA foi muito baixa (<<span class="elsevierStyleHsp" style=""></span>15%), o que pode ter implicações nos resultados.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conclusões</span><p id="par0165" class="elsevierStylePara elsevierViewall">Na nossa série, a TbANE em 12,5% dos casos, em que o tempo de sintomas até à reperfusão e o <span class="elsevierStyleItalic">score</span> SYNTAX foram os preditores independentes. Na análise mutlivariada, a ineficácia da TbA não se relacionou com maior área de enfarte ou com aumento de mortalidade a médio prazo.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Responsabilidades éticas</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Proteção de pessoas e animais</span><p id="par0170" class="elsevierStylePara elsevierViewall">Os autores declaram que para esta investigação não se realizaram experiências em seres humanos e/ou animais.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Confidencialidade dos dados</span><p id="par0175" class="elsevierStylePara elsevierViewall">Os autores declaram ter seguido os protocolos do seu centro de trabalho acerca da publicação dos dados de pacientes.</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Direito à privacidade e consentimento escrito</span><p id="par1175" class="elsevierStylePara elsevierViewall">Os autores declaram que não aparecem dados de pacientes neste artigo.</p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conflito de interesses</span><p id="par0185" class="elsevierStylePara elsevierViewall">Os autores declaram não haver conflito de interesses.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:2 [ "identificador" => "xres390355" "titulo" => array:5 [ 0 => "Resumo" 1 => "Introdução e objetivos" 2 => "Métodos" 3 => "Resultados" 4 => "Conclusões" ] ] 1 => array:2 [ "identificador" => "xpalclavsec368526" "titulo" => "Palavras‐chave" ] 2 => array:2 [ "identificador" => "xres390356" "titulo" => array:5 [ 0 => "Abstract" 1 => "Introduction and Objectives" 2 => "Methods" 3 => "Results" 4 => "Conclusions" ] ] 3 => array:2 [ "identificador" => "xpalclavsec368525" "titulo" => "Keywords" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introdução e objetivos" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Métodos" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "População estudada e definições" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Procedimento e medicação" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Análise estatística" ] ] ] 6 => array:2 [ "identificador" => "sec0030" "titulo" => "Resultados" ] 7 => array:2 [ "identificador" => "sec0035" "titulo" => "Discussão" ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Limitações" ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "Conclusões" ] 10 => array:3 [ "identificador" => "sec0050" "titulo" => "Responsabilidades éticas" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0055" "titulo" => "Proteção de pessoas e animais" ] 1 => array:2 [ "identificador" => "sec0060" "titulo" => "Confidencialidade dos dados" ] 2 => array:2 [ "identificador" => "sec0065" "titulo" => "Direito à privacidade e consentimento escrito" ] ] ] 11 => array:2 [ "identificador" => "sec0070" "titulo" => "Conflito de interesses" ] 12 => array:1 [ "titulo" => "Bibliografia" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-02-21" "fechaAceptado" => "2014-05-04" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras‐chave" "identificador" => "xpalclavsec368526" "palabras" => array:4 [ 0 => "Trombectomia" 1 => "Enfarte agudo de miocárdio" 2 => "Reperfusão" 3 => "Aspiração de trombo" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec368525" "palabras" => array:4 [ 0 => "Thrombus aspiration" 1 => "ST‐elevation myocardial infarction" 2 => "Reperfusion" 3 => "Thrombectomy" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introdução e objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">O benefício da trombectomia aspirativa manual (TbA) na reperfusão do enfarte de miocárdio com elevação de ST (EAMST) tem sido muito debatida. Na maioria das séries, a ineficácia da TbA tem sido pouco evidenciada. Os nossos objetivos visaram conhecer a taxa, os preditores e o impacto na mortalidade cumulativa da TbA ineficaz (TbANE) numa série de doentes submetidos a intervenção coronária percutânea primária (ICPP).</p> <span class="elsevierStyleSectionTitle" id="sect0015">Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudo retrospetivo, unicêntrico, consecutivo, de doentes com EAMST submetidos a ICPP com TbA. Considerou‐se TbANE se após a TbA e antes de prosseguir a angioplastia se se obtivesse fluxo coronário TIMI<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>2. Identificaram‐se preditores independentes de TbANE por regressão logística multivariada. Os preditores de mortalidade cumulativa foram identificados por modelo de Cox.</p> <span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Dentre 574 doentes, utilizou‐se a TbA em 417 (72,6%), que foi eficaz em 365 (87,5%), ineficaz em 52 (12,5%). Na análise multivariada, o <span class="elsevierStyleItalic">score</span> SYNTAX (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,049, 95% CI: 1,015‐1,084, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,005) e o tempo isquémico total (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,001, 95% CI: 1,000‐1,003, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,02) foram os preditores independentes de TbANE. A disfunção ventricular esquerda moderada/severa (HR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>6,256, 95% CI: 1,896‐20,644, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,003), o <span class="elsevierStyleItalic">score</span> APPROACH (HR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,094, 95% CI: 1,016‐1,177, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,017), a classe 3‐4 de Killip (HR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2,953, 95% CI: 1,122‐7,770, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,028) e a <span class="elsevierStyleItalic">clearance</span> da creatinina na admissão (HR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,973, 95% CI: 0,953‐0,994, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,011), relacionaram‐se de forma independente com a mortalidade cumulativa (24<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0,82 meses).</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusões</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">O tempo de sintomas e o <span class="elsevierStyleItalic">score</span> SYNTAX foram preditores independentes de TbANE. Contudo, a TbANE não teve impacto independente com a mortalidade cumulativa a médio prazo.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introduction and Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The benefit of manual thrombus aspiration (TA) in the reperfusion of patients with ST‐elevation myocardial infarction (STEMI) has been hotly debated. In most series, failure of TA has been largely unreported. Our objectives were to assess the rate, predictors, and impact on cumulative mortality of failed TA during primary percutaneous coronary intervention (PPCI).</p> <span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">This was a single‐center, retrospective study of consecutive STEMI patients undergoing PPCI with TA. TA was considered ineffective if, before angioplasty, coronary flow was TIMI <2. Independent predictors of TA failure were assessed by logistic regression, and predictors of cumulative mortality were assessed by Cox regression analysis.</p> <span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Of 574 patients, TA was used in 417 (72.6%), and was effective in 365 (87.5%) and ineffective in 52 (12.5%). On multivariate analysis, SYNTAX score (OR=1.049, 95% CI: 1.015–1.084, p=0.005) and total ischemic time (OR=1.001, 95% CI: 1.000–1.003, p=0.02) were independent predictors of TA failure. Moderate or severe left ventricular dysfunction (HR=6.256, 95% CI: 1.896–20.644, p=0.003), APPROACH score (HR=1.094, 95% CI: 1.016–1.177, p=0.017), Killip class III/IV (HR=2.953, 95% CI: 1.122–7.770, p=0.028) and creatinine clearance on admission (HR=0.973, 95% CI: 0.953–0.994, p=0.011) were independently related to cumulative mortality at 24±0.82 months.</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Total ischemic time and SYNTAX score were independent predictors of TA failure. However, in medium‐term follow‐up, ineffective manual TA was not independently related to cumulative mortality.</p>" ] ] "nomenclatura" => array:1 [ 0 => array:2 [ "identificador" => "nom0005" "listaDefinicion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleSectionTitle" id="sect0065">Abreviaturas e acrónimos</span>" "definicion" => array:13 [ 0 => array:2 [ "termino" => "TbA" "descripcion" => "<p id="par0190" class="elsevierStylePara elsevierViewall">Trombectomia aspirativa</p>" ] 1 => array:2 [ "termino" => "EAMST" "descripcion" => "<p id="par0195" class="elsevierStylePara elsevierViewall">Enfarte agudo de miocárdico com elevação de ST</p>" ] 2 => array:2 [ "termino" => "ICPP" "descripcion" => "<p id="par0200" class="elsevierStylePara elsevierViewall">Intervenção coronária percutânea primária</p>" ] 3 => array:2 [ "termino" => "TIMI" "descripcion" => "<p id="par0205" class="elsevierStylePara elsevierViewall">Thrombolysis in Myocardial Infarction</p>" ] 4 => array:2 [ "termino" => "TbAE" "descripcion" => "<p id="par0210" class="elsevierStylePara elsevierViewall">Trombectomia aspirativa eficaz</p>" ] 5 => array:2 [ "termino" => "TbANE" "descripcion" => "<p id="par0215" class="elsevierStylePara elsevierViewall">Trombectomia aspirativa não eficaz</p>" ] 6 => array:2 [ "termino" => "RMC" "descripcion" => "<p id="par0220" class="elsevierStylePara elsevierViewall">Ressonância Magnética Cardíaca</p>" ] 7 => array:2 [ "termino" => "ClCreat" "descripcion" => "<p id="par0225" class="elsevierStylePara elsevierViewall">Clearance da creatinina</p>" ] 8 => array:2 [ "termino" => "GRACE" "descripcion" => "<p id="par0230" class="elsevierStylePara elsevierViewall">Global Registry of Acute Coronary Events</p>" ] 9 => array:2 [ "termino" => "SYNTAX" "descripcion" => "<p id="par0235" class="elsevierStylePara elsevierViewall">Synergy between PCI with TAXUS drug‐eluting stent and Cardiac Surgery</p>" ] 10 => array:2 [ "termino" => "APPROACH" "descripcion" => "<p id="par0240" class="elsevierStylePara elsevierViewall">Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease</p>" ] 11 => array:2 [ "termino" => "TIT" "descripcion" => "<p id="par0245" class="elsevierStylePara elsevierViewall">Tempo isquémico total</p>" ] 12 => array:2 [ "termino" => "FEVE" "descripcion" => "<p id="par0250" class="elsevierStylePara elsevierViewall">Fracção de ejecção do ventrículo esquerdo</p>" ] ] ] ] ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1549 "Ancho" => 1659 "Tamanyo" => 79701 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Curva de mortalidade cumulativa em função da eficácia da trombectomia aspirativa.</p> <p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">TbAE: trombectomia aspirativa eficaz.</p> <p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">TbANE: trombectomia aspirativa não eficaz.</p>" ] ] 1 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Tabela 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">ARA: antagonista dos recetores da angiotensina <span class="elsevierStyleSmallCaps">II</span>; IECA: inibidor da enzima conversora da angiotensina; TbAE: trombectomia aspirativa eficaz; TbANE: trombectomia aspirativa não eficaz.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Características \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">TbAE \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">TbANE \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Valor de p \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Demografia e fatores de risco</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Idade (anos)<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>SD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">61,69<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>13,18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">64,65<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>12,77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,129 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">274 (75,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">39 (75,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,991 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Feminino (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">91 (24,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 (25,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,991 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diabetes (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">86 (23,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 (31,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,229 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipercolesterolemia (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">204 (56,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 (49,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,345 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipertensão (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">210 (57,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26 (52,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,446 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fumador (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">211 (58,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 (40) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,016 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Índice de massa corporal, kg/m<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>SD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26,48<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>3,63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26,69<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>3,62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,692 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antecedentes de enfarte (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22 (6,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (5,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,000 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Angina pré‐enfarte \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">129 (35,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 (35,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,962 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Clearance</span> creatinina (ml/min)<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>SD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">88,44<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>35,25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">82,43<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>40,52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,264 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hemoglobina (mg/dl) (IQR) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14,4 (2,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13,9 (2,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,083 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Medicação em curso</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bloqueador beta (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44 (12,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (10,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,659 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Estatina (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">79 (21,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (18) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,542 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IECAv(%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">61 (16,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (12,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,384 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ARAII (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">63 (17,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (18,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,917 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antagonistas do cálcio (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26 (7,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 (16,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,050 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Aspirina (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45 (12,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (14,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,754 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Clopidogrel (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 (3,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (2,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,707 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Insulina (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 (3,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2(4,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,000 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antidiabéticos orais (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56 (15,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8(16,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,929 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Nitratos (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 (4,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (10,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,082 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anticoagulantes orais (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37 (10,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (9,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,631 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Scores de risco</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>GRACE (IQR) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">213,0 (45,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">221,0 (54,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,022 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>TIMI (IQR) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3,0 (3,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4,0 (4,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,090 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Killip 3‐4 (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40 (11,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 (21,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,031 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab601533.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Variáveis demográficas e <span class="elsevierStyleItalic">scores</span> de risco</p>" ] ] 2 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Tabela 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">BIA: balão intra‐aórtico; CD: artéria coronária direita; CX: artéria circunflexa; DA: artéria descendente anterior; ICP: intervenção coronária percutânea; Inib: inibidores da glicoproteína 2b/3a.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Características \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">TbAE \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">TbANE \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Valor de p \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Tempos até reperfusão (minutos)</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tempo isquémico total (IQR) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">210,0 (248,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">332,5 (393,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Porta‐balão (IQR) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">70,0 (70,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">90,0 (75,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,095 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Pressão arterial sistólica (mmHg)</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">±</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">120<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>25,81 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">115<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>30,74 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,209 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Vaso alvo</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,006 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>DA (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">156 (42,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 (48,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CX (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44 (12,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (5,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CD (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">165 (45,2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22 (42,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tronco comum (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (3,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Acesso radial (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">182 (50,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28 (56,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,426 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Inib. 2b/3a (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">122 (33,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19 (38,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,530 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Colocação de BIA (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (1,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (11,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Tipo de stent</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,026 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Drug</span>‐<span class="elsevierStyleItalic">eluting stent</span> (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">202 (55,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 (48,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Bare</span>‐<span class="elsevierStyleItalic">metal</span> stent (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">151 (41,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 (40,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Balão (apenas) (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (3,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (11,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Scores angiográficos</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SYNTAX (IQR) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17,5 (10,25) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 (14,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>APPROACH modificado (IQR) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27,5 (11,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27,5 (15,45) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,963 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">ICP noutros vasos (%)</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">73 (20,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (14,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,313 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab601535.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Refere‐se a intervenção coronária percutânea de outros vasos que não o responsável pelo enfarte, na mesma estadia hospitalar.</p>" ] ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Variáveis relacionadas com o procedimento</p>" ] ] 3 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Tabela 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">ARA: antagonista dos recetores da angiotensina; CK: creatina kinase; CK‐<span class="elsevierStyleItalic">mass</span>: fração massa da CK; FEVE: fração de ejeção do ventrículo esquerdo; IECA: inibidor da enzima conversora da angiotensina; TbAE: trombectomia aspirativa eficaz; TbANE: trombectomia aspirativa não eficaz; TnT: troponina T.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Características \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">TbAE \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">TbANE \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Valor p \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Pico de CK (U/L) (IQR)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.160,0 (2622.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.143,0 (3.138,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,633<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Pico de CK‐massa (U/L) (IQR)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">218,5 (201,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">200,0 (219,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,091<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Pico de TnT (IQR)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5,12 (6,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4,64 (5,82) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,500<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">No‐reflow</span> (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (1,4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 (35,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">FEVE (n</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">=</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">395)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,164 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Preservada/disfunção ligeira (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">217 (62,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 (52,1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Disfunção moderada/severa (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">130 (37,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23 (47,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Killip 3‐4 (durante hospitalização) (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40 (11,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 (21,6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,031 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Mortalidade hospitalar (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22 (6,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (13,5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,073 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Dias internamento (mediana) (IQR)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6,0 (3,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (7,0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,005 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Medicação à data de alta (n</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">=</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">388)</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bloqueador beta (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">322 (93,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40 (88,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,222 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IECA/ARA II (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">255 (74,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35 (77,8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,590 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Estatina (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">336 (97,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42 (93,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,121 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Aspirina (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">343 (100) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45 (100) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,000 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Clopidogrel (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">343 (100) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45 (100) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,000 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab601534.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Valor de p calculado por teste‐t para amostras independentes após transformação logarítmica das variáveis CK, CK‐massa e TnT.</p>" ] ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Resultados hospitalares</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:45 [ 0 => 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| Ano/Mês | Html | Total | |
|---|---|---|---|
| 2024 Novembro | 6 | 5 | 11 |
| 2024 Outubro | 42 | 27 | 69 |
| 2024 Setembro | 42 | 20 | 62 |
| 2024 Agosto | 44 | 31 | 75 |
| 2024 Julho | 53 | 26 | 79 |
| 2024 Junho | 46 | 11 | 57 |
| 2024 Maio | 39 | 30 | 69 |
| 2024 Abril | 40 | 17 | 57 |
| 2024 Maro | 34 | 17 | 51 |
| 2024 Fevereiro | 31 | 37 | 68 |
| 2024 Janeiro | 34 | 26 | 60 |
| 2023 Dezembro | 38 | 20 | 58 |
| 2023 Novembro | 42 | 20 | 62 |
| 2023 Outubro | 20 | 25 | 45 |
| 2023 Setembro | 23 | 15 | 38 |
| 2023 Agosto | 26 | 17 | 43 |
| 2023 Julho | 21 | 5 | 26 |
| 2023 Junho | 22 | 9 | 31 |
| 2023 Maio | 43 | 17 | 60 |
| 2023 Abril | 25 | 7 | 32 |
| 2023 Maro | 24 | 21 | 45 |
| 2023 Fevereiro | 36 | 15 | 51 |
| 2023 Janeiro | 18 | 9 | 27 |
| 2022 Dezembro | 48 | 20 | 68 |
| 2022 Novembro | 56 | 21 | 77 |
| 2022 Outubro | 38 | 17 | 55 |
| 2022 Setembro | 25 | 32 | 57 |
| 2022 Agosto | 33 | 26 | 59 |
| 2022 Julho | 31 | 26 | 57 |
| 2022 Junho | 13 | 11 | 24 |
| 2022 Maio | 25 | 27 | 52 |
| 2022 Abril | 48 | 23 | 71 |
| 2022 Maro | 24 | 29 | 53 |
| 2022 Fevereiro | 22 | 13 | 35 |
| 2022 Janeiro | 31 | 17 | 48 |
| 2021 Dezembro | 16 | 23 | 39 |
| 2021 Novembro | 29 | 28 | 57 |
| 2021 Outubro | 25 | 31 | 56 |
| 2021 Setembro | 24 | 21 | 45 |
| 2021 Agosto | 22 | 31 | 53 |
| 2021 Julho | 24 | 18 | 42 |
| 2021 Junho | 30 | 19 | 49 |
| 2021 Maio | 31 | 24 | 55 |
| 2021 Abril | 52 | 28 | 80 |
| 2021 Maro | 56 | 14 | 70 |
| 2021 Fevereiro | 70 | 10 | 80 |
| 2021 Janeiro | 35 | 10 | 45 |
| 2020 Dezembro | 26 | 8 | 34 |
| 2020 Novembro | 34 | 15 | 49 |
| 2020 Outubro | 21 | 10 | 31 |
| 2020 Setembro | 22 | 8 | 30 |
| 2020 Agosto | 16 | 5 | 21 |
| 2020 Julho | 25 | 10 | 35 |
| 2020 Junho | 38 | 2 | 40 |
| 2020 Maio | 18 | 4 | 22 |
| 2020 Abril | 16 | 6 | 22 |
| 2020 Maro | 36 | 5 | 41 |
| 2020 Fevereiro | 30 | 19 | 49 |
| 2020 Janeiro | 31 | 7 | 38 |
| 2019 Dezembro | 12 | 2 | 14 |
| 2019 Novembro | 16 | 8 | 24 |
| 2019 Outubro | 42 | 2 | 44 |
| 2019 Setembro | 8 | 5 | 13 |
| 2019 Agosto | 20 | 7 | 27 |
| 2019 Julho | 34 | 6 | 40 |
| 2019 Junho | 31 | 11 | 42 |
| 2019 Maio | 28 | 13 | 41 |
| 2019 Abril | 22 | 10 | 32 |
| 2019 Maro | 71 | 7 | 78 |
| 2019 Fevereiro | 68 | 13 | 81 |
| 2019 Janeiro | 57 | 3 | 60 |
| 2018 Dezembro | 74 | 11 | 85 |
| 2018 Novembro | 111 | 7 | 118 |
| 2018 Outubro | 195 | 17 | 212 |
| 2018 Setembro | 19 | 13 | 32 |
| 2018 Agosto | 26 | 15 | 41 |
| 2018 Julho | 26 | 10 | 36 |
| 2018 Junho | 40 | 6 | 46 |
| 2018 Maio | 78 | 21 | 99 |
| 2018 Abril | 55 | 3 | 58 |
| 2018 Maro | 142 | 9 | 151 |
| 2018 Fevereiro | 57 | 9 | 66 |
| 2018 Janeiro | 51 | 10 | 61 |
| 2017 Dezembro | 45 | 9 | 54 |
| 2017 Novembro | 34 | 12 | 46 |
| 2017 Outubro | 47 | 16 | 63 |
| 2017 Setembro | 27 | 13 | 40 |
| 2017 Agosto | 41 | 8 | 49 |
| 2017 Julho | 22 | 9 | 31 |
| 2017 Junho | 27 | 15 | 42 |
| 2017 Maio | 33 | 10 | 43 |
| 2017 Abril | 20 | 4 | 24 |
| 2017 Maro | 42 | 47 | 89 |
| 2017 Fevereiro | 46 | 13 | 59 |
| 2017 Janeiro | 61 | 7 | 68 |
| 2016 Dezembro | 29 | 14 | 43 |
| 2016 Novembro | 18 | 12 | 30 |
| 2016 Outubro | 18 | 8 | 26 |
| 2016 Setembro | 29 | 10 | 39 |
| 2016 Agosto | 12 | 9 | 21 |
| 2016 Julho | 14 | 10 | 24 |
| 2016 Junho | 2 | 0 | 2 |
| 2016 Maio | 17 | 4 | 21 |
| 2016 Abril | 21 | 2 | 23 |
| 2016 Maro | 22 | 15 | 37 |
| 2016 Fevereiro | 53 | 22 | 75 |
| 2016 Janeiro | 43 | 21 | 64 |
| 2015 Dezembro | 36 | 16 | 52 |
| 2015 Novembro | 31 | 14 | 45 |
| 2015 Outubro | 30 | 21 | 51 |
| 2015 Setembro | 30 | 13 | 43 |
| 2015 Agosto | 40 | 14 | 54 |
| 2015 Julho | 40 | 10 | 50 |
| 2015 Junho | 28 | 4 | 32 |
| 2015 Maio | 48 | 9 | 57 |
| 2015 Abril | 37 | 16 | 53 |
| 2015 Maro | 37 | 17 | 54 |
| 2015 Fevereiro | 44 | 19 | 63 |
| 2015 Janeiro | 97 | 58 | 155 |
| 2014 Dezembro | 95 | 72 | 167 |
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