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sofrerem de patologia ou terem fatores de risco associados&#44; sendo certo que&#44; para Portugal&#44; ser&#225; pequena a frequ&#234;ncia dos pHTA que&#44; tratados&#44; est&#227;o controlados<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#8211;13</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A ades&#227;o e a manuten&#231;&#227;o em terap&#234;utica dos pHTA s&#227;o fen&#243;menos essenciais ao controlo da HTA e devem ser pensados n&#227;o como um comportamento desleixado&#44; mas como o resultado de uma experi&#234;ncia subjetiva da viv&#234;ncia com a HTA&#46; Usualmente a HTA n&#227;o d&#225; sintomas ou sinais at&#233; ao aparecimento de complica&#231;&#245;es&#44; o que dificulta a capacita&#231;&#227;o dos pHTA&#44; pelo que o acidente ou a complica&#231;&#227;o podem ser fen&#243;menos de n&#227;o ades&#227;o e manuten&#231;&#227;o em terap&#234;utica<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">H&#225; que ter em conta a necessidade de tratar&#44; mas sem causar dano nem desperd&#237;cio&#44; em particular na HTA moderada&#44; tal como veio demonstrar recente revis&#227;o de 2012<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&#46; Existe&#44; em particular&#44; a discuss&#227;o sobre os valores definidores de HTA&#58; se os presentes 140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg se os anteriores 160&#47;100<span class="elsevierStyleHsp" style=""></span>mmHg&#44; numa tentativa de perceber se &#233; justificado o investimento a ser realizado por indiv&#237;duos&#44; fam&#237;lias e sociedade<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;16</span></a>&#46; &#201; que outros fatores podem estar associados&#44; quer alimentares&#44; quer medicamentosos&#44; quer de conhecimento&#44; que devem obrigar os m&#233;dicos a pensar&#44; para a melhor efici&#234;ncia na terap&#234;utica da HTA<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Pelo acima exposto surge a necessidade de perceber as diferen&#231;as entre os pHTA controlados e n&#227;o controlados&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Objetivos</span><p id="par0045" class="elsevierStylePara elsevierViewall">Verificar as diferen&#231;as entre caracter&#237;sticas de pacientes sofrendo de HTA controlada ou n&#227;o controlada&#46; Especificamente verificar se h&#225; diferen&#231;as quanto &#224; idade&#44; ao sexo&#44; &#224; exist&#234;ncia de acidente cardiovascular pr&#233;vio&#44; &#224; associa&#231;&#227;o de outras patologias&#44; ao n&#250;mero de medicamentos anti&#8208;hipertensores&#44; ao tipo de medicamentos anti&#8208;hipertensores&#44; &#224; medica&#231;&#227;o com clorotalidona&#44; &#224; toma de&#44; pelo menos&#44; um anti&#8208;hipertensor &#224; noite e ao consumo concomitante de AINE&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Metodologia</span><p id="par0050" class="elsevierStylePara elsevierViewall">Estudo observacional&#44; anal&#237;tico&#44; aleat&#243;rio&#44; com reposi&#231;&#227;o&#44; na popula&#231;&#227;o de tr&#234;s ficheiros cl&#237;nicos de m&#233;dicos de uma unidade de sa&#250;de familiar&#44; no concelho de Coimbra&#44; em junho de 2013&#44; com HTA diagnosticada e registada pela codifica&#231;&#227;o ICPC&#8208;2 &#40;com ou sem complica&#231;&#245;es&#41; at&#233; ao dia 13 de maio de 2013&#44; data em que foram criados os ficheiros de casos a estudar&#46; Amostra calculada para um intervalo de confian&#231;a de 95&#37; e margem de erro de 6&#37; em cada um dos ficheiros&#44; assumindo&#8208;se uma frequ&#234;ncia de controlo de 50&#37;&#46; Ap&#243;s obten&#231;&#227;o de listagens por ordem ascendente do n&#250;mero nacional de utente foi feita colheita dos dados&#44; pelos autores&#44; por consulta de todos os processos aleatorizados&#44; no programa espec&#237;fico de HTA e no ambiente de prescri&#231;&#227;o do servi&#231;o de apoio ao m&#233;dico &#40;SAM&#41;&#46; Em caso de aus&#234;ncia de dados de leitura de tens&#227;o arterial&#44; nos &#250;ltimos nove meses&#44; foi estudado o elemento imediatamente anterior da listagem&#44; mantendo&#8208;se a anterior seria&#231;&#227;o&#46; No caso de este tamb&#233;m n&#227;o ter dados foi estudado o elemento logo a seguir ao aleatorizado&#44; mantendo&#8208;se a anterior seria&#231;&#227;o&#46; Mantendo&#8208;se a aus&#234;ncia de dados seguiu&#8208;se o processo de aleatoriza&#231;&#227;o previamente definido&#44; ou seja&#44; o quinto elemento seguinte ao inicialmente aleatorizado&#46; Foi obtida a concord&#226;ncia de todos os m&#233;dicos detentores dos ficheiros cl&#237;nicos&#44; bem como o parecer positivo da Comiss&#227;o de &#201;tica da Administra&#231;&#227;o de Sa&#250;de Regional do Centro&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">O valor de tens&#227;o arterial considerado foi o da m&#233;dia das tr&#234;s &#250;ltimas medi&#231;&#245;es no ambiente de trabalho do programa de HTA do SAM&#44; num per&#237;odo m&#237;nimo de nove meses de avalia&#231;&#245;es&#44; sendo feitas tr&#234;s medi&#231;&#245;es em cada consulta&#46; A medica&#231;&#227;o foi estudada atrav&#233;s do conhecimento do n&#250;mero de diferentes denomina&#231;&#245;es comuns internacionais &#40;DCI&#41;&#46; Para conhecimento do medicamento tomado &#224; noite pesquisou&#8208;se a sua prescri&#231;&#227;o nas receitas eletr&#243;nicas de cada paciente&#44; para o per&#237;odo dos &#250;ltimos nove meses&#46; Para conhecimento de simultaneidade de AINE foi tamb&#233;m acedido o m&#243;dulo de prescri&#231;&#227;o&#44; considerando positiva a associa&#231;&#227;o quando havia prescri&#231;&#227;o continuada de AINE nos &#250;ltimos nove meses&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">O estudo foi feito com base nas classifica&#231;&#245;es de doen&#231;a cr&#243;nica que os m&#233;dicos ao longo do tempo colocaram&#44; como antecedentes pessoais&#44; no processo eletr&#243;nico dos seus consulentes segundo as defini&#231;&#245;es operacionais que s&#227;o divulgadas&#46; Assim e quando presentes no programa de HTA do SAM&#44; usaram&#8208;se as seguintes defini&#231;&#245;es&#44; constantes do programa&#44; para&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><p id="par0065" class="elsevierStylePara elsevierViewall">Les&#227;o em &#243;rg&#227;o&#8208;alvo&#58; Acidente Vascular Cerebral&#47;Acidente Isqu&#233;mico Transit&#243;rio&#44; Insufici&#234;ncia Card&#237;aca Congestiva&#44; Hipertrofia Ventricular Esquerda&#44; Doen&#231;a Renal&#44; Ateromatose&#44; Retinopatia&#59;</p></li><li class="elsevierStyleListItem" id="lsti0010"><p id="par0070" class="elsevierStylePara elsevierViewall">Ter outra patologia associada&#58; Nefropatia&#44; Doen&#231;a Coron&#225;ria&#44; Doen&#231;a Vascular&#44; Enfarte Agudo do Mioc&#225;rdio&#59;</p></li><li class="elsevierStyleListItem" id="lsti0015"><p id="par0075" class="elsevierStylePara elsevierViewall">Outra patologia&#58; Diabetes <span class="elsevierStyleItalic">Mellitus</span>&#44; Doen&#231;a Glomerular e Dislipidemia&#46;</p></li></ul></p><p id="par0080" class="elsevierStylePara elsevierViewall">A defini&#231;&#227;o da patologia constante de cada um dos cap&#237;tulos acima &#233; a consensualmente existente em fun&#231;&#227;o dos valores anal&#237;ticos e dos exames auxiliares de diagn&#243;stico realizados a cada paciente&#44; sendo a sua coloca&#231;&#227;o em base de dados da responsabilidade do m&#233;dico&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Definiram&#8208;se as vari&#225;veis dicot&#243;micas ter ou n&#227;o ter e&#44; quanto &#224; idade&#44; criou&#8208;se o grupo de idade igual ou superior a 65 anos e o grupo at&#233; aos 64 anos&#44; inclusive&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Realizou&#8208;se estat&#237;stica descritiva e inferencial param&#233;trica&#44; ap&#243;s verifica&#231;&#227;o da normalidade dos dados&#44; com o t de student&#44; para vari&#225;veis n&#227;o emparelhadas e&#44; para estudo entre vari&#225;veis nominais&#44; o &#967;<span class="elsevierStyleSup">2</span>&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><p id="par0095" class="elsevierStylePara elsevierViewall">De uma popula&#231;&#227;o de n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>972 &#40;preval&#234;ncia da HTA de 20&#44;2&#37;&#41; estudou&#8208;se uma amostra&#44; de n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>201 indiv&#237;duos&#44; sendo 104 homens &#40;51&#44;7&#37;&#41;&#44; tendo n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>86 menos de 65 anos &#40;42&#44;8&#37;&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;127 entre sexo e grupo et&#225;rio&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Os resultados s&#227;o mostrados na tabela&#44; sendo de real&#231;ar que&#44; para n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>130 &#40;64&#44;7&#37;&#41; da amostra&#44; h&#225; controlo da HTA&#46; Verifica&#8208;se que a LOA &#233; significativamente mais frequente nos pHTA controlados &#40;33&#44;1 <span class="elsevierStyleItalic">versus</span> 19&#44;7&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;031&#41; que&#44; quando h&#225; toma de&#44; pelo menos&#44; um medicamento &#224; noite&#44; tamb&#233;m h&#225; maior frequ&#234;ncia de controlo &#40;56&#44;9 <span class="elsevierStyleItalic">versus</span> 29&#44;6&#37;&#44; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; e que a toma conjunta de AINE&#39;s &#233; mais frequente nos pHTA n&#227;o controlados &#40;3&#44;8 <span class="elsevierStyleItalic">versus</span> 11&#44;3&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;043&#41;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Segunda a <a class="elsevierStyleCrossRef" href="#tbl0005">Tabela 1</a>&#44; verifica&#8208;se que 66&#44;5&#37; dos pHTA est&#227;o medicados com diur&#233;tico e que&#44; destes&#44; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>31 &#40;24&#44;3&#37;&#41; s&#227;o do DCI clorotalidona&#44; sendo muito baixa a prescri&#231;&#227;o de anti&#8208;inflamat&#243;rios n&#227;o esteroides &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#44; 6&#44;5&#37;&#41;&#46; Dos pHTA encontram&#8208;se&#44; com dois medicamentos&#44; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>86 &#40;42&#44;8&#37;&#41; e&#44; com tr&#234;s medicamentos&#44; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>57 &#40;28&#44;4&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Para os pacientes da amostra em 28&#44;4&#37; havia registo de LOA&#44; em 29&#44;9&#37; de patologia associada e em 28&#44;4&#37; de outra patologia&#44; tal como mostra a <a class="elsevierStyleCrossRef" href="#tbl0010">Tabela 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">Na <a class="elsevierStyleCrossRef" href="#tbl0015">Tabela 3</a> apresenta&#8208;se a distribui&#231;&#227;o dos v&#225;rios tipos de classes terap&#234;uticas&#44; por controlo ou n&#227;o de HTA&#44; nos 194 pHTA medicados e que &#233; significativamente diferente&#46; Os diur&#233;ticos s&#227;o a classe mais prescrita&#44; seguindo&#8208;se os antagonistas dos recetores tipo 1 da angiotensina&#46; &#201; maior a frequ&#234;ncia de diur&#233;ticos nos n&#227;o controlados e maior a prescri&#231;&#227;o dos medicamentos que atuam no sistema renina&#8208;angiotensina&#8208;aldosterna&#44; na situa&#231;&#227;o de controlo de HTA&#46; Em monoterapia a classe mais frequente &#233; a dos inibidores da enzima de convers&#227;o da angiotensina&#44; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17 &#40;8&#44;5&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discuss&#227;o</span><p id="par0120" class="elsevierStylePara elsevierViewall">O conhecimento dos determinantes de bons resultados&#44; em patologias&#44; que s&#227;o afer&#237;veis por valores decis&#243;rios&#44; &#233; importante&#44; em particular quando est&#227;o envolvidos valores econ&#243;micos e financeiros importantes&#44; quer de encargos quer de custos&#44; estruturais e processuais&#44; bem como de resultado que&#44; em termos individuais&#44; familiares e sociais&#44; podem ser pesados&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">O conhecimento do ambiente que estud&#225;mos pode ser feito por v&#225;rios tipos de estudo&#46; Opt&#225;mos por um estudo transversal e de base populacional&#44; verificando o estado dos pHTA que aleatoriamente estud&#225;mos&#44; assim se tendo reduzido o enviesamento&#46; O tamanho da amostra considera&#8208;se ser suficiente para a demonstra&#231;&#227;o de resultados&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Num estudo que incluiu n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>86 &#40;42&#44;8&#37;&#41; pacientes com mais de 65 anos foi feita op&#231;&#227;o pelo valor de corte de 140<span class="elsevierStyleHsp" style=""></span>mmHg e de 90<span class="elsevierStyleHsp" style=""></span>mmHg&#44; de press&#227;o sist&#243;lica e diast&#243;lica&#44; mesmo que outros valores sejam discutidos<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;15&#44;16</span></a>&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Segundo literatura nacional e internacional continuar&#225; baixa a frequ&#234;ncia de pHTA controlados o que&#44; no presente caso&#44; n&#227;o se verifica&#44; com 64&#44;7&#37; de frequ&#234;ncia de controlo&#44; havendo assim melhores resultados que os de anteriores estudos&#44; em Portugal&#44; que referiam 11&#44;2&#37; em 2011 e 42&#44;6&#37; em 2012<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;11</span></a>&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Verific&#225;mos que&#44; sem significado&#44; o homem tem maior frequ&#234;ncia de n&#227;o controlo&#44; fator que deve levar aqueles que trabalham com eles a desenvolver maior esfor&#231;o terap&#234;utico e&#44; eventualmente&#44; informativo<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">O facto de j&#225; ter havido acidente vascular tem impacto importante no controlo&#46; Parece assim que quem j&#225; teve acidente passa a ter um muito maior cuidado consigo ou passa a ser alvo de maior cuidado terap&#234;utico pela equipa que o trata&#44; o que dever&#225; vir a ser estudado&#46; O trabalho de interven&#231;&#227;o terap&#234;utica e a explica&#231;&#227;o sobre o problema de sa&#250;de parece dever ser mais elaborado pelo m&#233;dico e respetiva equipa de sa&#250;de&#44; ficando assim o paciente mais conhecedor do seu problema&#44; ao mesmo tempo que deve saber&#8208;se da capacita&#231;&#227;o que ter&#225; ocorrido na consulta acerca do problema de sa&#250;de<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a>&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Estes resultados contrastam com os encontrados em estudo igualmente populacional na regi&#227;o do grande Porto&#44; mas no qual o enfoque est&#225; sobretudo no conhecimento que os pHTA det&#234;m sobre a HTA<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Os pHTA n&#227;o controlados t&#234;m&#44; sem significado&#44; maior frequ&#234;ncia de outra patologia associada e menor frequ&#234;ncia de uso de clorotalidona&#46; Ser&#225; que&#44; com o aumento do uso deste diur&#233;tico tiaz&#237;dico&#44; haver&#225; melhores resultados assim se reafirmando os resultados do ALLHATT<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;8</span></a>&#63;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Verifica&#8208;se o padr&#227;o de prescri&#231;&#227;o j&#225; descrito em outros estudos&#44; em Portugal&#44; com elevada frequ&#234;ncia de prescri&#231;&#227;o de medicamentos atuando no sistema renina&#8208;angiotensina&#8208;aldosterona&#44; sendo poss&#237;vel que este esquema de terap&#234;utica farmacol&#243;gica possa acarretar marcados benef&#237;cios futuros&#44; controlando melhor a press&#227;o arterial central<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#8211;21</span></a>&#46; No entanto&#44; neste nosso estudo&#44; &#233; maior a propor&#231;&#227;o dos pHTA medicados com dois ou mais medicamentos&#44; o que pode ajudar a perceber o melhor desempenho terap&#234;utico medido pela frequ&#234;ncia dos PHTA controlados<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;19</span></a>&#46; Ter prescri&#231;&#227;o de&#44; pelo menos&#44; um medicamento &#224; noite tem resultados com diferen&#231;a significativa no controlo da press&#227;o arterial&#44; ficando assim verificado o que o MAPEC Study j&#225; havia referido<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46; A cronoterapia dever&#225; assim ser implementada&#46; &#201; muito baixa a frequ&#234;ncia de simult&#226;nea prescri&#231;&#227;o de AINE nesta popula&#231;&#227;o&#44; fruto&#44; talvez&#44; de estudos que foram feitos com os m&#233;dicos prescritores<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&#46; Neste estudo verific&#225;mos o resultado pr&#225;tico da interface pHTA&#47;equipa cuidadora&#47;medica&#231;&#227;o atrav&#233;s dos registos inform&#225;ticos existentes&#46; H&#225; fatores que n&#227;o foram estudados&#44; como a ades&#227;o e manuten&#231;&#227;o em terap&#234;utica e a capacita&#231;&#227;o efetuada na consulta&#44; bem como o seu esbatimento ao longo do tempo&#44; e que podem marcadamente interferir com o controlo e a que futuros trabalhos dever&#227;o responder<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#8211;28</span></a>&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Em conclus&#227;o&#44; num estudo populacional&#44; aleatorizado e com amostra representativa&#44; os pacientes com HTA que j&#225; tiveram acidente cardiovascular t&#234;m melhor controlo&#46; Com significado verifica&#8208;se que a toma de&#44; pelo menos&#44; um anti&#8208;hipertensor &#224; noite &#233; fator de melhor controlo de HTA&#44; bem como a aus&#234;ncia de simult&#226;nea prescri&#231;&#227;o de anti&#8208;inflamat&#243;rios n&#227;o esteroides&#46; Sem significado verifica&#8208;se que os mais novos n&#227;o est&#227;o mais controlados&#44; a associa&#231;&#227;o de outras patologias n&#227;o piora o controlo&#44; que maior n&#250;mero de medicamentos anti&#8208;hipertensores melhoram o controlo&#44; que a utiliza&#231;&#227;o de diur&#233;ticos n&#227;o melhora o controlo e que a clorotalidona est&#225; associada a maior frequ&#234;ncia de controlo de HTA&#46; Para 64&#44;7&#37; da amostra h&#225; situa&#231;&#227;o de controlo da HTA no &#250;ltimo conjunto de tr&#234;s medi&#231;&#245;es de press&#227;o arterial no consult&#243;rio m&#233;dico&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Responsabilidades &#233;ticas</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Prote&#231;&#227;o de pessoas e animais</span><p id="par0175" class="elsevierStylePara elsevierViewall">Os autores declaram que para esta investiga&#231;&#227;o n&#227;o se realizaram experi&#234;ncias em seres humanos e&#47;ou animais&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Confidencialidade dos dados</span><p id="par0180" class="elsevierStylePara elsevierViewall">Os autores declaram ter seguido os protocolos de seu centro de trabalho acerca da publica&#231;&#227;o dos dados de pacientes e que todos os pacientes inclu&#237;dos no estudo receberam informa&#231;&#245;es suficientes e deram o seu consentimento informado por escrito para participar nesse estudo&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Direito &#224; privacidade e consentimento escrito</span><p id="par0185" class="elsevierStylePara elsevierViewall">Os autores declaram que n&#227;o aparecem dados de pacientes neste artigo&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflito de interesses</span><p id="par0190" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflito de interesses&#46;</p></span></span>"
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          "identificador" => "sec0020"
          "titulo" => "Resultados"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Discuss&#227;o"
        ]
        9 => array:3 [
          "identificador" => "sec0030"
          "titulo" => "Responsabilidades &#233;ticas"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Prote&#231;&#227;o de pessoas e animais"
            ]
            1 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Confidencialidade dos dados"
            ]
            2 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Direito &#224; privacidade e consentimento escrito"
            ]
          ]
        ]
        10 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Conflito de interesses"
        ]
        11 => array:1 [
          "titulo" => "Bibliografia"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2013-09-05"
    "fechaAceptado" => "2013-12-02"
    "PalabrasClave" => array:2 [
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras&#8208;chave"
          "identificador" => "xpalclavsec359624"
          "palabras" => array:6 [
            0 => "Hipertens&#227;o arterial"
            1 => "Medicamentos"
            2 => "Les&#227;o em &#243;rg&#227;o&#8208;alvo"
            3 => "Controlo"
            4 => "Cronoterapia"
            5 => "Anti&#8208;inflamat&#243;rios n&#227;o esteroides"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec359623"
          "palabras" => array:6 [
            0 => "Hypertension"
            1 => "Medicines"
            2 => "Target organ damage"
            3 => "Control"
            4 => "Chronotherapy"
            5 => "Non&#8208;steroidal anti&#8208;inflammatory drugs"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar a preval&#234;ncia e comparar diferen&#231;as entre pacientes hipertensos controlados e n&#227;o controlados&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Metodologia</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudo observacional&#44; anal&#237;tico&#44; em junho de 2013&#44; na popula&#231;&#227;o de tr&#234;s ficheiros cl&#237;nicos de m&#233;dicos de uma unidade de sa&#250;de familiar no concelho de Coimbra&#44; com hipertens&#227;o arterial &#40;HTA&#41; diagnosticada e registada pela codifica&#231;&#227;o ICPC&#8208;2 &#40;com e sem complica&#231;&#245;es&#41; at&#233; ao dia 13 de maio de 2013&#46; Amostra calculada para um intervalo de confian&#231;a de 95&#37; e margem de erro de 6&#37; em cada um dos ficheiros&#44; ap&#243;s obten&#231;&#227;o de listagens por ordem ascendente do n&#250;mero nacional de utente&#44; assumindo uma frequ&#234;ncia de controlo de 50&#37;&#46; Colheita dos dados pelos autores&#44; por consulta de todos os processos aleatorizados&#44; com reposi&#231;&#227;o&#44; no programa espec&#237;fico de HTA e no ambiente de prescri&#231;&#227;o do servi&#231;o de apoio ao m&#233;dico &#40;SAM&#41;&#44; ap&#243;s parecer positivo da Comiss&#227;o de &#201;tica da Administra&#231;&#227;o de Sa&#250;de Regional do Centro&#46; Controlo de HTA se nas tr&#234;s &#250;ltimas espa&#231;adas leituras o valor era inferior a 140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudou&#8208;se uma amostra de n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>201 indiv&#237;duos&#44; sendo 104 homens &#40;51&#44;7&#37;&#41; e tendo menos de 65 anos 86 &#40;42&#44;8&#37;&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;127 entre sexo e grupo et&#225;rio&#41;&#46; Para n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>130 &#40;64&#44;7&#37;&#41; da amostra h&#225; controlo da HTA&#46; A les&#227;o em &#243;rg&#227;o&#8208;alvo &#233; significativamente mais frequente nos pacientes com HTA controlada &#40;33&#44;1 <span class="elsevierStyleItalic">versus</span> 19&#44;7&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;031&#41;&#46; Quando h&#225; toma de pelo menos um medicamento &#224; noite h&#225; maior frequ&#234;ncia de controlo &#40;56&#44;9 <span class="elsevierStyleItalic">versus</span> 29&#44;6&#37;&#44; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; A simultaneidade de prescri&#231;&#227;o de anti&#8208;inflamat&#243;rios n&#227;o esteroides &#233; mais frequente nos pacientes com HTA n&#227;o controlada &#40;11&#44;3 <span class="elsevierStyleItalic">versus</span> 3&#44;8&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;043&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclus&#227;o</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">S&#227;o fatores significativamente mais frequentes no controlo da HTA o pr&#233;vio acidente cardiovascular&#44; a toma de pelo menos um anti&#8208;hipertensor &#224; noite e a aus&#234;ncia de simult&#226;nea prescri&#231;&#227;o de anti&#8208;inflamat&#243;rios n&#227;o esteroides&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study the differences between controlled and uncontrolled hypertensive patients&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">This was a cross&#8208;sectional observational study of the hypertensive population on the lists of three general practitioners in the district of Coimbra in central Portugal in 2013&#44; with a margin of error of 6&#37; and 95&#37; confidence interval in each sample&#44; organized in ascending order of health care user numbers&#46; Data were gathered electronically by the investigators after approval by the Regional Health Authority&#39;s ethics committee&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">A sample of 201 individuals was studied&#44; of whom 104 &#40;51&#46;7&#37;&#41; were male and 86 &#40;42&#46;8&#37;&#41; were aged under 65 &#40;p&#61;0&#46;127 for gender and age&#8208;group&#41;&#46; Hypertension was controlled in 130 &#40;64&#46;7&#37;&#41;&#46; We found significant differences in target organ damage&#44; more frequent in those with controlled hypertension &#40;33&#46;1&#37; vs&#46; 19&#46;7&#37;&#44; p&#61;0&#46;031&#41;&#44; in hypertension control&#44; better in those taking at least one anti&#8208;hypertensive drug at night &#40;56&#46;9&#37; vs&#46; 29&#46;6&#37;&#44; p&#60;0&#46;001&#41;&#44; and in prescription of non&#8208;steroidal anti&#8208;inflammatory drugs&#44; more frequent in those with uncontrolled hypertension &#40;11&#46;3&#37; vs&#46; 3&#46;8&#37;&#44; p&#61;0&#46;043&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusion</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Hypertension control is significantly associated with target organ damage&#44; taking at least one anti&#8208;hypertensive drug at night and not taking non&#8208;steroidal anti&#8208;inflammatory drugs simultaneously&#46;</p>"
      ]
    ]
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                  \t\t\t\t" style="border-bottom: 2px solid black">HTA controlada &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>130&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;871&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Um s&#243; DCI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">34 &#40;56&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">66 &#40;50&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">31 &#40;43&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t">58 &#40;44&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">28 &#40;38&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;288&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">125 &#40;96&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63 &#40;88&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Resultados encontrados entre pHTA controlados e n&#227;o controlados</p>"
        ]
      ]
      1 => array:7 [
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Les&#227;o em &#243;rg&#227;o&#8208;alvo</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Acidente vascular cerebral &#47; acidente isqu&#233;mico transit&#243;rio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">15 &#40;26&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Insufici&#234;ncia card&#237;aca congestiva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;35&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Doen&#231;a renal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;14&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ateromatose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;31&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Retinopatia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;3&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Outra patologia associada</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Nefropatia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;19&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Doen&#231;a coron&#225;ria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;57&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Doen&#231;a vascular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;45&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfarte agudo do mioc&#225;rdio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;11&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Outra patologia</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diabetes <span class="elsevierStyleItalic">mellitus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69 &#40;47&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Doen&#231;a glomerular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;9&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dislipidemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">104 &#40;72&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "tabla" => array:2 [
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Classe farmacoterap&#234;utica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">HTA controlada n &#40;&#37;&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">HTA n&#227;o controlada n &#40;&#37;&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Total n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diur&#233;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75 &#40;26&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48 &#40;33&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">123 &#40;28&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Beta&#8208;bloqueadores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;10&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;9&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43 &#40;10&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bloqueadores dos canais de c&#225;lcio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44 &#40;15&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;20&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">74 &#40;17&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Inibidores da enzima de convers&#227;o da angiotensina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70 &#40;24&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;15&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92 &#40;21&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antagonistas dos recetores tipo 1<span class="elsevierStyleHsp" style=""></span>da angiotensina 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65 &#40;23&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;20&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">95 &#40;22&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Outros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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