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besides having been diagnosed two weeks previously with Crohn&#39;s disease for which he was medicated with mesalamine 1500 mg twice a day and budesonide 9 mg daily&#44; was admitted to the local hospital with retrosternal chest pain radiating to the left arm&#46; He reported no accompanying symptoms and no relieving or aggravating factors were identified&#46; The patient had no reported previous infection&#46; The physical examination was unremarkable and there were no signs of hemodynamic instability or heart failure&#46; The initial 12-lead electrocardiogram revealed sinus rhythm and slight ST-segment elevation with upward concavity in leads I&#44; II&#44; III&#44; aVF and V3&#8211;V6 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46; As laboratory tests showed elevated cardiac necrosis biomarkers &#40;troponin I 9&#46;1 ng&#47;ml&#41;&#44; he was transferred to our hospital for cardiological evaluation&#46; Following admission to the cardiac care unit&#44; he mentioned some episodes of chest pain which improved after treatment with aspirin&#46; Repeated blood tests demonstrated a further increase in cardiac biomarkers &#40;peak troponin I 27&#46;3 ng&#47;ml and peak total CK 915 IU&#47;l&#41; accompanied by elevation of NT-proBNP &#40;6413 pg&#47;ml&#41; and inflammatory parameters &#40;C-reactive protein 130 mg&#47;l&#44; 15<span class="elsevierStyleHsp" style=""></span>800 leukocytes&#41;&#46; Remodeling therapy with ACE inhibitors and beta-blockers was also introduced&#44; due to the moderately depressed left ventricular systolic function &#40;ejection fraction of 38&#37;&#41; seen on the transthoracic echocardiogram&#44; with global hypocontractility&#44; although more noticeable in the posterior&#44; inferior and lateral walls &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#46; Cardiac magnetic resonance imaging &#40;MRI&#41; with delayed gadolinium enhancement revealed multiple areas of myocardial fibrosis&#44; mainly subepicardial&#44; suggesting a non-ischemic pattern &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>&#41;&#46; There was no sign of myocardial infarction and the patient was therefore diagnosed with acute myocarditis&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">In view of mesalamine&#39;s cardiovascular toxicity as described in the literature&#44; this drug was discontinued shortly after admission&#46; The patient remained asymptomatic thereafter and laboratory tests were favorable &#40;NT-proBNP 905 pg&#47;ml and troponin I 0&#46;13 ng&#47;ml at discharge&#41;&#46; Electrocardiograms showed progressive resolution of ST-segment elevation and the echocardiogram was repeated one week later&#44; demonstrating improvement in left ventricular systolic function &#40;ejection fraction of 45&#37;&#41;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">Classic myocarditis refers to inflammation of the heart muscle as a result of exposure to either discrete external antigen triggers&#44; such as viruses&#44; bacteria&#44; parasites or drugs&#44; or to internal triggers such as autoimmune activation against self-antigens&#46; Drugs can act as a direct toxic agent &#40;anthracyclines and cocaine&#41; or by a hypersensitivity reaction&#44; as is thought to be the case with mesalamine and other medications &#40;clozapine&#44; sulfonamides&#44; cephalosporins&#44; penicillins and tricyclic antidepressants&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Cardiac disease can be associated with Crohn&#39;s disease as an extraintestinal manifestation of inflammatory bowel disease or as a consequence of drug-induced side effects&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4</span></a> Myocarditis associated with mesalamine is a rare but potentially serious phenomenon&#44; generally occurring 2&#8211;4 weeks after the initial exposure to the drug&#44; although presentation may be delayed over years&#44; especially if steroids are used concomitantly&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Mesalamine&#39;s mechanism of action is not fully understood&#44; but it includes inhibition of the cyclooxygenase pathway&#44; inducing an anti-inflammatory effect in the colon&#46; The exact mechanism for mesalamine-induced myocardial inflammation is not clearly identified&#44; but it is thought to be a hypersensitivity reaction rather than a cytotoxic effect&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> One proposed mechanism is humoral-mediated hypersensitivity&#44; in which antibodies formed against mesalamine cross-react with cardiac tissue causing inflammation&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The diagnosis of hypersensitivity myocarditis is supported by two facts&#58; inflammation worsens if mesalamine is reintroduced during the acute phase&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and resolution of symptoms occurs within one week after drug discontinuation&#44; as has been described in all reported cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4</span></a> Eosinophilic infiltration of the myocardium on endomyocardial biopsy has also been described&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> which seems to confirm the link between mesalamine and hypersensitivity myocarditis&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In our case&#44; the onset and resolution of symptoms were similar to those reported in the literature&#46; Soon after discontinuing mesalamine&#44; our patient evolved well&#44; with progressive falls in cardiac biomarkers and improvement in left ventricular systolic function&#46; Considering this evolution and the fact that there was no previous infection&#44; mesalamine-induced myocarditis was considered to be the most likely diagnosis&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusion</span><p id="par0035" class="elsevierStylePara elsevierViewall">This case illustrates the importance of eliciting a thorough medical history and being aware of the timing when new medications are started&#46; It is imperative that any new onset of chest pain in the setting of inflammatory bowel disease treated with mesalamine should be evaluated via cardiac enzymes&#44; electrocardiogram&#44; echocardiogram and possibly cardiac MRI to rapidly diagnose any complication caused by either the inflammatory bowel disease itself or an adverse drug reaction&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data and that all the patients included in the study received sufficient information and gave their written informed consent to participate in the study&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflict of interests</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare&#46;</p></span></span>"
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Case report
Mesalamine-induced myocarditis following diagnosis of Crohn's disease: A case report
Miocardite induzida pela mesalamina após o diagnóstico de doença de Crohn – relato de um caso clínico
Carlos Galvão Braga
Autor para correspondência
carlos.galvaobraga@gmail.com

Corresponding author.
, Juliana Martins, Carina Arantes, Vítor Ramos, Catarina Vieira, Alberto Salgado, Sónia Magalhães, Adelino Correia
Serviço de Cardiologia, Hospital de Braga, Braga, Portugal
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    "titulo" => "Mesalamine-induced myocarditis following diagnosis of Crohn&#39;s disease&#58; A case report"
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        "titulo" => "Miocardite induzida pela mesalamina ap&#243;s o diagn&#243;stico de doen&#231;a de Crohn &#8211; relato de um caso cl&#237;nico"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Electrocardiogram on day of chest pain onset&#58; sinus rhythm and slight ST-segment elevation with upward concavity in leads I&#44; II&#44; III&#44; aVF and V3&#8211;V6&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Mesalamine &#40;5-aminosalicylic acid&#41; is a well-known treatment for inflammatory bowel disease&#44; often used as the first-line drug&#46; Although rare&#44; adverse cardiac reactions due to mesalamine have been described in the literature&#44; and include pericarditis&#44; myocarditis&#44; coronary vasculitis and left ventricular dysfunction&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4</span></a> We report a case of mesalamine-induced myocarditis in a patient with a recent diagnosis of Crohn&#39;s disease&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 19-year-old male with no relevant medical history&#44; besides having been diagnosed two weeks previously with Crohn&#39;s disease for which he was medicated with mesalamine 1500 mg twice a day and budesonide 9 mg daily&#44; was admitted to the local hospital with retrosternal chest pain radiating to the left arm&#46; He reported no accompanying symptoms and no relieving or aggravating factors were identified&#46; The patient had no reported previous infection&#46; The physical examination was unremarkable and there were no signs of hemodynamic instability or heart failure&#46; The initial 12-lead electrocardiogram revealed sinus rhythm and slight ST-segment elevation with upward concavity in leads I&#44; II&#44; III&#44; aVF and V3&#8211;V6 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46; As laboratory tests showed elevated cardiac necrosis biomarkers &#40;troponin I 9&#46;1 ng&#47;ml&#41;&#44; he was transferred to our hospital for cardiological evaluation&#46; Following admission to the cardiac care unit&#44; he mentioned some episodes of chest pain which improved after treatment with aspirin&#46; Repeated blood tests demonstrated a further increase in cardiac biomarkers &#40;peak troponin I 27&#46;3 ng&#47;ml and peak total CK 915 IU&#47;l&#41; accompanied by elevation of NT-proBNP &#40;6413 pg&#47;ml&#41; and inflammatory parameters &#40;C-reactive protein 130 mg&#47;l&#44; 15<span class="elsevierStyleHsp" style=""></span>800 leukocytes&#41;&#46; Remodeling therapy with ACE inhibitors and beta-blockers was also introduced&#44; due to the moderately depressed left ventricular systolic function &#40;ejection fraction of 38&#37;&#41; seen on the transthoracic echocardiogram&#44; with global hypocontractility&#44; although more noticeable in the posterior&#44; inferior and lateral walls &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#46; Cardiac magnetic resonance imaging &#40;MRI&#41; with delayed gadolinium enhancement revealed multiple areas of myocardial fibrosis&#44; mainly subepicardial&#44; suggesting a non-ischemic pattern &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>&#41;&#46; There was no sign of myocardial infarction and the patient was therefore diagnosed with acute myocarditis&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">In view of mesalamine&#39;s cardiovascular toxicity as described in the literature&#44; this drug was discontinued shortly after admission&#46; The patient remained asymptomatic thereafter and laboratory tests were favorable &#40;NT-proBNP 905 pg&#47;ml and troponin I 0&#46;13 ng&#47;ml at discharge&#41;&#46; Electrocardiograms showed progressive resolution of ST-segment elevation and the echocardiogram was repeated one week later&#44; demonstrating improvement in left ventricular systolic function &#40;ejection fraction of 45&#37;&#41;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">Classic myocarditis refers to inflammation of the heart muscle as a result of exposure to either discrete external antigen triggers&#44; such as viruses&#44; bacteria&#44; parasites or drugs&#44; or to internal triggers such as autoimmune activation against self-antigens&#46; Drugs can act as a direct toxic agent &#40;anthracyclines and cocaine&#41; or by a hypersensitivity reaction&#44; as is thought to be the case with mesalamine and other medications &#40;clozapine&#44; sulfonamides&#44; cephalosporins&#44; penicillins and tricyclic antidepressants&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Cardiac disease can be associated with Crohn&#39;s disease as an extraintestinal manifestation of inflammatory bowel disease or as a consequence of drug-induced side effects&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4</span></a> Myocarditis associated with mesalamine is a rare but potentially serious phenomenon&#44; generally occurring 2&#8211;4 weeks after the initial exposure to the drug&#44; although presentation may be delayed over years&#44; especially if steroids are used concomitantly&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Mesalamine&#39;s mechanism of action is not fully understood&#44; but it includes inhibition of the cyclooxygenase pathway&#44; inducing an anti-inflammatory effect in the colon&#46; The exact mechanism for mesalamine-induced myocardial inflammation is not clearly identified&#44; but it is thought to be a hypersensitivity reaction rather than a cytotoxic effect&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> One proposed mechanism is humoral-mediated hypersensitivity&#44; in which antibodies formed against mesalamine cross-react with cardiac tissue causing inflammation&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The diagnosis of hypersensitivity myocarditis is supported by two facts&#58; inflammation worsens if mesalamine is reintroduced during the acute phase&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and resolution of symptoms occurs within one week after drug discontinuation&#44; as has been described in all reported cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4</span></a> Eosinophilic infiltration of the myocardium on endomyocardial biopsy has also been described&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> which seems to confirm the link between mesalamine and hypersensitivity myocarditis&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In our case&#44; the onset and resolution of symptoms were similar to those reported in the literature&#46; Soon after discontinuing mesalamine&#44; our patient evolved well&#44; with progressive falls in cardiac biomarkers and improvement in left ventricular systolic function&#46; Considering this evolution and the fact that there was no previous infection&#44; mesalamine-induced myocarditis was considered to be the most likely diagnosis&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusion</span><p id="par0035" class="elsevierStylePara elsevierViewall">This case illustrates the importance of eliciting a thorough medical history and being aware of the timing when new medications are started&#46; It is imperative that any new onset of chest pain in the setting of inflammatory bowel disease treated with mesalamine should be evaluated via cardiac enzymes&#44; electrocardiogram&#44; echocardiogram and possibly cardiac MRI to rapidly diagnose any complication caused by either the inflammatory bowel disease itself or an adverse drug reaction&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data and that all the patients included in the study received sufficient information and gave their written informed consent to participate in the study&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflict of interests</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare&#46;</p></span></span>"
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mesalamine is a common treatment for Crohn&#39;s disease&#44; and can be rarely associated with myocarditis through a mechanism of drug hypersensitivity&#46; We present the case of a 19-year-old male who developed chest pain two weeks after beginning mesalamine therapy&#46; The electrocardiogram showed slight ST-segment elevation with upward concavity in the inferolateral leads&#59; blood tests demonstrated elevated troponin I and the echocardiogram revealed moderately depressed left ventricular systolic function with global hypocontractility&#46; Cardiac magnetic resonance imaging confirmed the diagnosis of myocarditis&#44; revealing multiple areas of subepicardial fibrosis&#46; The onset of symptoms after mesalamine&#44; and improvement of chest pain&#44; cardiac biomarkers and left ventricular systolic function after discontinuing the drug&#44; suggest that our patient suffered from a rare drug-hypersensitivity reaction to mesalamine&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A mesalamina &#233; um tratamento comum para a doen&#231;a de Crohn&#44; associando-se de forma rara &#224; miocardite aguda&#44; atrav&#233;s de uma rea&#231;&#227;o de hipersensibilidade ao f&#225;rmaco&#46; Os autores apresentam o caso cl&#237;nico de um jovem de 19 anos com aparecimento de dor tor&#225;cica duas semanas ap&#243;s ter iniciado tratamento com mesalamina para a doen&#231;a de Crohn&#46; O eletrocardiograma mostrou um discreto supradesnivelamento do segmento ST&#44; de concavidade ascendente&#44; nas deriva&#231;&#245;es infero-laterais&#59; as an&#225;lises revelaram eleva&#231;&#227;o da troponina I e o ecocardiograma exibiu uma depress&#227;o moderada da fun&#231;&#227;o sist&#243;lica do ventr&#237;culo esquerdo&#44; por hipocontractilidade global&#46; A resson&#226;ncia magn&#233;tica card&#237;aca confirmou o diagn&#243;stico de miocardite&#44; evidenciando m&#250;ltiplas &#225;reas de fibrose subepic&#225;rdica&#46; O in&#237;cio dos sintomas ap&#243;s o come&#231;o da mesalamina e a melhoria da dor tor&#225;cica&#44; biomarcadores card&#237;acos e fun&#231;&#227;o sist&#243;lica ventricular esquerda ap&#243;s a suspens&#227;o do medicamento&#44; sugerem que o nosso paciente teve uma rea&#231;&#227;o rara de hipersensibilidade &#224; mesalamina&#46;</p>"
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Informação do artigo
ISSN: 08702551
Idioma original: Inglês
Dados atualizados diariamente
Ano/Mês Html Pdf Total
2024 Novembro 18 9 27
2024 Outubro 85 29 114
2024 Setembro 110 25 135
2024 Agosto 78 32 110
2024 Julho 53 30 83
2024 Junho 47 29 76
2024 Maio 72 19 91
2024 Abril 40 31 71
2024 Maro 57 27 84
2024 Fevereiro 44 22 66
2024 Janeiro 39 23 62
2023 Dezembro 53 29 82
2023 Novembro 46 16 62
2023 Outubro 54 17 71
2023 Setembro 42 21 63
2023 Agosto 48 19 67
2023 Julho 34 15 49
2023 Junho 33 10 43
2023 Maio 48 22 70
2023 Abril 47 7 54
2023 Maro 57 22 79
2023 Fevereiro 42 18 60
2023 Janeiro 35 10 45
2022 Dezembro 42 16 58
2022 Novembro 50 30 80
2022 Outubro 40 23 63
2022 Setembro 43 26 69
2022 Agosto 40 28 68
2022 Julho 39 26 65
2022 Junho 32 18 50
2022 Maio 26 31 57
2022 Abril 42 30 72
2022 Maro 30 31 61
2022 Fevereiro 32 23 55
2022 Janeiro 39 25 64
2021 Dezembro 46 22 68
2021 Novembro 66 36 102
2021 Outubro 41 51 92
2021 Setembro 48 30 78
2021 Agosto 57 29 86
2021 Julho 61 31 92
2021 Junho 53 12 65
2021 Maio 44 30 74
2021 Abril 72 38 110
2021 Maro 81 14 95
2021 Fevereiro 83 29 112
2021 Janeiro 42 14 56
2020 Dezembro 36 13 49
2020 Novembro 43 16 59
2020 Outubro 22 10 32
2020 Setembro 50 8 58
2020 Agosto 27 5 32
2020 Julho 50 5 55
2020 Junho 41 9 50
2020 Maio 61 0 61
2020 Abril 42 11 53
2020 Maro 65 6 71
2020 Fevereiro 119 37 156
2020 Janeiro 38 6 44
2019 Dezembro 36 12 48
2019 Novembro 41 3 44
2019 Outubro 67 6 73
2019 Setembro 95 12 107
2019 Agosto 49 17 66
2019 Julho 53 11 64
2019 Junho 34 6 40
2019 Maio 48 5 53
2019 Abril 36 14 50
2019 Maro 107 12 119
2019 Fevereiro 103 12 115
2019 Janeiro 104 6 110
2018 Dezembro 102 12 114
2018 Novembro 94 15 109
2018 Outubro 160 21 181
2018 Setembro 41 10 51
2018 Agosto 50 13 63
2018 Julho 48 7 55
2018 Junho 72 5 77
2018 Maio 62 15 77
2018 Abril 73 6 79
2018 Maro 90 7 97
2018 Fevereiro 63 6 69
2018 Janeiro 78 4 82
2017 Dezembro 95 20 115
2017 Novembro 67 5 72
2017 Outubro 45 17 62
2017 Setembro 59 11 70
2017 Agosto 56 14 70
2017 Julho 46 21 67
2017 Junho 37 9 46
2017 Maio 88 13 101
2017 Abril 43 32 75
2017 Maro 34 12 46
2017 Fevereiro 72 7 79
2017 Janeiro 38 14 52
2016 Dezembro 50 15 65
2016 Novembro 41 11 52
2016 Outubro 59 12 71
2016 Setembro 120 17 137
2016 Agosto 46 8 54
2016 Julho 23 18 41
2016 Junho 3 19 22
2016 Maio 21 0 21
2016 Abril 62 3 65
2016 Maro 85 13 98
2016 Fevereiro 109 15 124
2016 Janeiro 101 15 116
2015 Dezembro 107 10 117
2015 Novembro 94 10 104
2015 Outubro 73 10 83
2015 Setembro 111 14 125
2015 Agosto 87 16 103
2015 Julho 136 13 149
2015 Junho 55 11 66
2015 Maio 88 13 101
2015 Abril 70 17 87
2015 Maro 80 11 91
2015 Fevereiro 65 8 73
2015 Janeiro 73 17 90
2014 Dezembro 74 15 89
2014 Novembro 42 12 54
2014 Outubro 62 11 73
2014 Setembro 58 31 89
2014 Agosto 42 11 53
2014 Julho 64 12 76
2014 Junho 50 12 62
2014 Maio 56 14 70
2014 Abril 71 14 85
2014 Maro 104 23 127
2014 Fevereiro 95 28 123
2014 Janeiro 116 43 159
2013 Dezembro 92 40 132
2013 Novembro 100 38 138
2013 Outubro 98 46 144
2013 Setembro 13 7 20
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