Estatísticas

 array:25 [
  "pii" => "S0870255113000383"
  "issn" => "08702551"
  "doi" => "10.1016/j.repc.2012.09.007"
  "estado" => "S300"
  "fechaPublicacion" => "2013-05-01"
  "aid" => "254"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2012"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Cardiol. 2013;32:373-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 9297
    "formatos" => array:3 [
      "EPUB" => 211
      "HTML" => 7386
      "PDF" => 1700
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:20 [
      "pii" => "S217420491300086X"
      "issn" => "21742049"
      "doi" => "10.1016/j.repce.2012.09.011"
      "estado" => "S300"
      "fechaPublicacion" => "2013-05-01"
      "aid" => "254"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "article"
      "crossmark" => 0
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Rev Port Cardiol. 2013;32:373-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5145
        "formatos" => array:3 [
          "EPUB" => 159
          "HTML" => 3927
          "PDF" => 1059
        ]
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
        "titulo" => "CHADS<span class="elsevierStyleInf">2</span> and CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>VASc scores as predictors of cardioembolic sources in secondary stroke prevention"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "pt"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "373"
            "paginaFinal" => "378"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "CHADS<span class="elsevierStyleInf">2</span> e CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>VASc como preditores de fonte cardioemb&#243;lica em preven&#231;&#227;o secund&#225;ria cerebrovascular"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "pt" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figure 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2049
                "Ancho" => 1618
                "Tamanyo" => 102692
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">ROC curve analysis of sensitivity and specificity of the CHADS<span class="elsevierStyleInf">2</span> and CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc risk scores&#46; The points indicate the cutoffs assuming equal importance for sensitivity and specificity and correspond to CHADS<span class="elsevierStyleInf">2</span> score &#8805;4 and CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc score &#8805;5&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Tiago S&#225;, Jo&#227;o Sargento-Freitas, V&#237;tor Pinheiro, Rui Martins, Rog&#233;rio Teixeira, Fernando Silva, Nuno Mendon&#231;a, Gustavo Cordeiro, Lino Gon&#231;alves, Lu&#237;s A&#46; Provid&#234;ncia, Ant&#243;nio Freire-Gon&#231;alves, Lu&#237;s Cunha"
            "autores" => array:12 [
              0 => array:2 [
                "nombre" => "Tiago"
                "apellidos" => "S&#225;"
              ]
              1 => array:2 [
                "nombre" => "Jo&#227;o"
                "apellidos" => "Sargento-Freitas"
              ]
              2 => array:2 [
                "nombre" => "V&#237;tor"
                "apellidos" => "Pinheiro"
              ]
              3 => array:2 [
                "nombre" => "Rui"
                "apellidos" => "Martins"
              ]
              4 => array:2 [
                "nombre" => "Rog&#233;rio"
                "apellidos" => "Teixeira"
              ]
              5 => array:2 [
                "nombre" => "Fernando"
                "apellidos" => "Silva"
              ]
              6 => array:2 [
                "nombre" => "Nuno"
                "apellidos" => "Mendon&#231;a"
              ]
              7 => array:2 [
                "nombre" => "Gustavo"
                "apellidos" => "Cordeiro"
              ]
              8 => array:2 [
                "nombre" => "Lino"
                "apellidos" => "Gon&#231;alves"
              ]
              9 => array:2 [
                "nombre" => "Lu&#237;s A&#46;"
                "apellidos" => "Provid&#234;ncia"
              ]
              10 => array:2 [
                "nombre" => "Ant&#243;nio"
                "apellidos" => "Freire-Gon&#231;alves"
              ]
              11 => array:2 [
                "nombre" => "Lu&#237;s"
                "apellidos" => "Cunha"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "pt" => array:9 [
          "pii" => "S0870255113000383"
          "doi" => "10.1016/j.repc.2012.09.007"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "pt"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255113000383?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217420491300086X?idApp=UINPBA00004E"
      "url" => "/21742049/0000003200000005/v1_201308021409/S217420491300086X/v1_201308021409/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S087025511300070X"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2012.09.008"
    "estado" => "S300"
    "fechaPublicacion" => "2013-05-01"
    "aid" => "270"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Cardiol. 2013;32:379-86"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 13259
      "formatos" => array:3 [
        "EPUB" => 201
        "HTML" => 11157
        "PDF" => 1901
      ]
    ]
    "pt" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo original</span>"
      "titulo" => "Hipercolesterolemia &#8211; uma patologia com express&#227;o desde a idade pedi&#225;trica"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => "pt"
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "379"
          "paginaFinal" => "386"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Hypercholesterolemia&#58; A disease with expression from childhood"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figura 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 895
              "Ancho" => 1674
              "Tamanyo" => 69212
            ]
          ]
          "descripcion" => array:1 [
            "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Redu&#231;&#227;o do colesterol LDL ap&#243;s interven&#231;&#227;o terap&#234;utica &#40;valores medianos&#44; quartis inferior e superior&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Maria C&#233;u Espinheira, Carla Vasconcelos, Ana Margarida Medeiros, Ana Catarina Alves, Mafalda Bourbon, Ant&#243;nio Guerra"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Maria C&#233;u"
              "apellidos" => "Espinheira"
            ]
            1 => array:2 [
              "nombre" => "Carla"
              "apellidos" => "Vasconcelos"
            ]
            2 => array:2 [
              "nombre" => "Ana Margarida"
              "apellidos" => "Medeiros"
            ]
            3 => array:2 [
              "nombre" => "Ana Catarina"
              "apellidos" => "Alves"
            ]
            4 => array:2 [
              "nombre" => "Mafalda"
              "apellidos" => "Bourbon"
            ]
            5 => array:2 [
              "nombre" => "Ant&#243;nio"
              "apellidos" => "Guerra"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2174204913000883"
        "doi" => "10.1016/j.repce.2012.09.013"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204913000883?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087025511300070X?idApp=UINPBA00004E"
    "url" => "/08702551/0000003200000005/v1_201308021350/S087025511300070X/v1_201308021350/pt/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S0870255113000759"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2013.03.003"
    "estado" => "S300"
    "fechaPublicacion" => "2013-05-01"
    "aid" => "275"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "dis"
    "cita" => "Rev Port Cardiol. 2013;32:371-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4041
      "formatos" => array:3 [
        "EPUB" => 195
        "HTML" => 3083
        "PDF" => 763
      ]
    ]
    "pt" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Coment&#225;rio editorial</span>"
      "titulo" => "Bal&#227;o eluidor de f&#225;rmaco&#58; o caminho faz-se caminhando"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => "pt"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "371"
          "paginaFinal" => "372"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Drug-eluting balloons&#58; The path is made by walking"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ant&#243;nio Leit&#227;o Marques"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Ant&#243;nio"
              "apellidos" => "Leit&#227;o Marques"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2174204913000834"
        "doi" => "10.1016/j.repce.2013.03.008"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204913000834?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255113000759?idApp=UINPBA00004E"
    "url" => "/08702551/0000003200000005/v1_201308021350/S0870255113000759/v1_201308021350/pt/main.assets"
  ]
  "pt" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original</span>"
    "titulo" => "CHADS<span class="elsevierStyleInf">2</span> e CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>VASc como preditores de fonte cardioemb&#243;lica em preven&#231;&#227;o secund&#225;ria cerebrovascular"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "373"
        "paginaFinal" => "378"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Tiago S&#225;, Jo&#227;o Sargento-Freitas, V&#237;tor Pinheiro, Rui Martins, Rog&#233;rio Teixeira, Fernando Silva, Nuno Mendon&#231;a, Gustavo Cordeiro, Lino Gon&#231;alves, Lu&#237;s A&#46; Provid&#234;ncia, Ant&#243;nio Freire-Gon&#231;alves, Lu&#237;s Cunha"
        "autores" => array:12 [
          0 => array:3 [
            "nombre" => "Tiago"
            "apellidos" => "S&#225;"
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "fn0005"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Jo&#227;o"
            "apellidos" => "Sargento-Freitas"
            "email" => array:1 [
              0 => "jsargentof&#64;hotmail&#46;com"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "fn0005"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "V&#237;tor"
            "apellidos" => "Pinheiro"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Rui"
            "apellidos" => "Martins"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Rog&#233;rio"
            "apellidos" => "Teixeira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Fernando"
            "apellidos" => "Silva"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Nuno"
            "apellidos" => "Mendon&#231;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Gustavo"
            "apellidos" => "Cordeiro"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "Lino"
            "apellidos" => "Gon&#231;alves"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          9 => array:3 [
            "nombre" => "Lu&#237;s A&#46;"
            "apellidos" => "Provid&#234;ncia"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          10 => array:3 [
            "nombre" => "Ant&#243;nio"
            "apellidos" => "Freire-Gon&#231;alves"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          11 => array:3 [
            "nombre" => "Lu&#237;s"
            "apellidos" => "Cunha"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Faculdade de Medicina&#44; Universidade de Coimbra&#44; Coimbra&#44; Portugal"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidade de Acidentes Vasculares Cerebrais&#44; Servi&#231;o de Neurologia&#44; Centro Hospitalar Universit&#225;rio de Coimbra&#44; Hospitais da Universidade de Coimbra&#44; Coimbra&#44; Portugal"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servi&#231;o de Cardiologia&#44; Centro Hospitalar Universit&#225;rio de Coimbra&#44; Hospitais da Universidade de Coimbra&#44; Coimbra&#44; Portugal"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "Autor para correspond&#234;ncia&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "CHADS<span class="elsevierStyleInf">2</span> and CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>VASc scores as predictors of cardioembolic sources in secondary stroke prevention"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2039
            "Ancho" => 1618
            "Tamanyo" => 103403
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Curva ROC representativa da sensibilidade e especificidade das escalas de risco cardioemb&#243;lico CHADS<span class="elsevierStyleInf">2</span> e CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc&#46; Os pontos representados indicam o valor de corte&#44; assumindo igual import&#226;ncia para sensibilidade e especificidade e correspondem a CHADS<span class="elsevierStyleInf">2</span> &#8805;&#160;4 e CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc &#8805;&#160;5&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introdu&#231;&#227;o</span><p id="par0005" class="elsevierStylePara elsevierViewall">O acidente vascular cerebral &#40;AVC&#41; &#233; a segunda causa de morte no mundo<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#44; atingindo propor&#231;&#245;es particularmente alarmantes em Portugal&#44; onde a taxa de mortalidade por AVC &#233; de cerca de 200&#47;100&#160;000 habitantes&#44; uma das mais elevadas da Uni&#227;o Europeia<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Do ponto de vista anatomopatol&#243;gico e fisiopatol&#243;gico&#44; os acidentes vasculares cerebrais s&#227;o divididos em dois grupos&#58; isqu&#233;micos &#40;80&#37;&#41; e hemorr&#225;gicos &#40;20&#37;&#41;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46; Os AVC isqu&#233;micos podem ser divididos segundo a classifica&#231;&#227;o etiol&#243;gica <span class="elsevierStyleItalic">Trial of Org 10172 in Acute Stroke Treatment</span> &#40;TOAST&#41; em cinco subtipos principais&#58; aterotromb&#243;ticos&#44; cardioemb&#243;licos&#44; doen&#231;a de pequenos vasos&#44; outra causa conhecida&#44; causa desconhecida<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Uma etiologia cardioemb&#243;lica &#233; atribu&#237;da a cerca de 20 a 30&#37; dos doentes com AVC isqu&#233;mico<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#46; Diversas patologias card&#237;acas aumentam o risco de ocorr&#234;ncia de AVC&#44; sendo a fibrilha&#231;&#227;o auricular &#40;FA&#41; a sua causa mais comum<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46; Os f&#225;rmacos anticoagulantes demonstraram reduzir eficazmente o risco de recorr&#234;ncia de AVC isqu&#233;mico neste subtipo etiol&#243;gico&#44; estando&#44; por isso&#44; fortemente recomendada a sua utiliza&#231;&#227;o no contexto da preven&#231;&#227;o prim&#225;ria e secund&#225;ria<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Com o objetivo de estratificar o risco de ocorr&#234;ncia de eventos cerebrovasculares cardioemb&#243;licos&#44; foi criada a escala de risco CHADS<span class="elsevierStyleInf">2</span><a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#46; Existem atualmente recomenda&#231;&#245;es que relacionam a pontua&#231;&#227;o obtida com a aplica&#231;&#227;o desta escala e o plano terap&#234;utico antitromb&#243;tico a adotar<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>&#46; Recentemente&#44; com o intuito de otimizar a anterior classifica&#231;&#227;o&#44; foi criada uma nova escala de risco cardioemb&#243;lico&#44; a CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc&#46; Contudo&#44; e apesar da sua valida&#231;&#227;o numa popula&#231;&#227;o heterog&#233;nea de doentes com FA em preven&#231;&#227;o prim&#225;ria<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a>&#44; desconhece-se ainda a sua validade em contexto de preven&#231;&#227;o secund&#225;ria cerebrovascular&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">O ecocardiograma transesof&#225;gico &#40;ETE&#41; &#233; um exame invasivo que d&#225; uma boa informa&#231;&#227;o anat&#243;mica da crossa da aorta&#44; aur&#237;cula esquerda&#44; ap&#234;ndice auricular esquerdo&#44; v&#225;lvula mitral e v&#225;lvula a&#243;rtica&#46; Esta t&#233;cnica &#233; dotada de elevada sensibilidade e especificidade na dete&#231;&#227;o de fonte cardioemb&#243;lica&#44; possuindo uma capacidade tr&#234;s vezes superior ao ecocardiograma transtor&#225;cico &#40;ETT&#41; para atingir esse fim<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">O objetivo deste estudo &#233; estudar uma poss&#237;vel associa&#231;&#227;o entre as escalas de risco cardioemb&#243;lico &#40;CHADS<span class="elsevierStyleInf">2</span> e CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc&#41; e a presen&#231;a de fonte cardioemb&#243;lica&#44; identificada com recurso a ETE&#44; em doentes com patologia cerebrovascular isqu&#233;mica&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">M&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Materiais e popula&#231;&#227;o</span><p id="par0035" class="elsevierStylePara elsevierViewall">Inclu&#237;mos no estudo todos os doentes internados na Unidade de AVC&#47;Enfermaria cerebrovascular de Neurologia de um hospital central portugu&#234;s com diagn&#243;stico de FA &#40;pr&#233;vio ou obtido durante&#47;ap&#243;s o internamento&#41; que realizaram ecocardiograma transesof&#225;gico &#40;ETE&#41; para estudo de fonte cardioemb&#243;lica entre janeiro e agosto de 2011&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">O estudo por ETE foi realizado at&#233; cinco&#160;dias ap&#243;s o evento vascular no servi&#231;o de Cardiologia do mesmo hospital utilizando um ecocardi&#243;grafo <span class="elsevierStyleItalic">&#40;GE Vivid 7 Dimension&#41;</span> equipado com uma sonda multiplanar transesof&#225;gica 6<span class="elsevierStyleHsp" style=""></span>Tc RS&#46; Foi definido como demonstra&#231;&#227;o de fonte cardioemb&#243;lica ativa a presen&#231;a em ETE de trombos nas cavidades card&#237;acas esquerdas ou autocontraste espont&#226;neo na aur&#237;cula e ap&#234;ndice auricular esquerdos<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Foram registadas as vari&#225;veis cl&#237;nicas &#40;hipertens&#227;o arterial&#44; diabetes <span class="elsevierStyleItalic">mellitus</span>&#44; coronariopatia&#44; insufici&#234;ncia card&#237;aca congestiva&#44; tabagismo&#44; dislipid&#233;mia&#44; antecedentes pessoais de acidente vascular cerebral&#44; alcoolismo&#41;&#44; demogr&#225;ficas &#40;sexo e idade&#41; e anal&#237;ticas dos doentes por consulta dos processos cl&#237;nicos&#46; O diagn&#243;stico de FA foi assumido ap&#243;s visualiza&#231;&#227;o direta de exames complementares que o confirmavam&#46; Nos doentes previamente anticoagulados &#40;10&#59; 10&#44;6&#37;&#41; foi avaliada a efic&#225;cia da anticoagula&#231;&#227;o estudando o valor de INR &#224; data da realiza&#231;&#227;o do ETE &#40;&#177;&#160;72<span class="elsevierStyleHsp" style=""></span>h&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Todos os doentes foram classificados de acordo com as escalas de risco vascular CHADS<span class="elsevierStyleInf">2</span><a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> e CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&#46; Compar&#225;mos todas as vari&#225;veis cl&#237;nicas&#44; demogr&#225;ficas e de risco cardiovascular para avaliar poss&#237;veis associa&#231;&#245;es com presen&#231;a de fonte cardioemb&#243;lica&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Finalmente&#44; avali&#225;mos pontos de corte&#44; sensibilidade&#44; especificidade e valor preditivo positivo e negativo das escalas de risco cardioemb&#243;lico como preditoras de cardioembolia ativa&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">An&#225;lise estat&#237;stica</span><p id="par0060" class="elsevierStylePara elsevierViewall">Efetu&#225;mos a an&#225;lise estat&#237;stica utilizando o <span class="elsevierStyleItalic">software</span> IBM SPSS Statistics 20&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Realiz&#225;mos an&#225;lise estat&#237;stica descritiva com c&#225;lculo de m&#233;dia e desvio padr&#227;o &#40;DP&#41; para as vari&#225;veis quantitativas e do n&#250;mero absoluto &#40;NA&#41; e percentagem para as vari&#225;veis qualitativas&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Compar&#225;mos vari&#225;veis demogr&#225;ficas e preval&#234;ncia de fatores de risco vascular&#44; entre doentes com e sem fonte cardioemb&#243;lica ativa utilizando o teste de chi-quadrado ou teste exato de Fischer&#44; quando adequado para vari&#225;veis qualitativas e o teste t de Student para vari&#225;veis independentes com vari&#225;veis quantitativas&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Compar&#225;mos o valor obtido ap&#243;s a aplica&#231;&#227;o das diferentes escalas de risco cardioemb&#243;lico e a data da realiza&#231;&#227;o do ETE com a presen&#231;a ou n&#227;o de fonte cardioemb&#243;lica ativa documentada por ETE utilizando o teste U de Mann-Whitney para duas vari&#225;veis independentes&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Efetu&#225;mos curvas <span class="elsevierStyleItalic">Reciever Operater Caractristic</span> &#40;ROC&#41; para a determina&#231;&#227;o de valores de corte preditores de fonte cardioemb&#243;lica na popula&#231;&#227;o total de doentes&#44; assumindo igual import&#226;ncia de sensibilidade e especificidade para cada uma das escalas referidas&#46; Esta an&#225;lise foi ent&#227;o repetida na subpopula&#231;&#227;o de doentes n&#227;o anticoagulados para avaliar a robustez dos resultados&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Definiu-se como signific&#226;ncia estat&#237;stica p&#160;&#60;&#160;0&#44;05&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Popula&#231;&#227;o estudada</span><p id="par0090" class="elsevierStylePara elsevierViewall">Durante o per&#237;odo estudado&#44; foram diagnosticadas doen&#231;as cerebrovasculares isqu&#233;micas &#40;AIT&#47;AVC&#41; a 313 doentes&#46; Destes&#44; 94 doentes &#40;30&#44;0&#37;&#41; com diagn&#243;stico de FA foram submetidos &#224; realiza&#231;&#227;o de ecocardiograma transesof&#225;gico &#40;ETE&#41;&#46; O diagn&#243;stico de FA havia sido obtido previamente a internamento em 66 &#40;70&#44;2&#37;&#41;&#44; durante este em 25 &#40;26&#44;6&#37;&#41; e ap&#243;s o internamento em 3 &#40;3&#44;2&#37;&#41;&#46; Identific&#225;mos fonte cardioemb&#243;lica ativa em 20 doentes &#40;21&#44;3&#37;&#41; sendo caracterizada por autocontraste espont&#226;neo nas cavidades card&#237;acas esquerdas em 19 doentes &#40;20&#44;2&#37;&#41;&#44; trombos nas cavidades card&#237;acas esquerdas em um &#40;1&#44;1&#37;&#41; e pela presen&#231;a simult&#226;nea de ambos em oito &#40;8&#44;5&#37;&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Apresentamos na <a class="elsevierStyleCrossRef" href="#tbl0005">Tabela 1</a> as caracter&#237;sticas demogr&#225;ficas&#44; fatores de risco vascular e resultados ecocardiogr&#225;ficos da popula&#231;&#227;o em estudo&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">&#192; data de alta hospitalar&#44; 91 doentes &#40;96&#44;8&#37;&#41; estavam anticoagulados&#44; tendo os restantes tr&#234;s &#40;3&#44;2&#37;&#41; contraindica&#231;&#227;o &#224; sua utiliza&#231;&#227;o&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Risco cardioemb&#243;lico e ecocardiograma transesof&#225;gico</span><p id="par0105" class="elsevierStylePara elsevierViewall">A <a class="elsevierStyleCrossRef" href="#tbl0010">Tabela 2</a> apresenta a compara&#231;&#227;o realizada entre a pontua&#231;&#227;o obtida com a aplica&#231;&#227;o das escalas CHADS<span class="elsevierStyleInf">2</span> e CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc e a presen&#231;a ou n&#227;o de fonte cardioemb&#243;lica ativa documentada por ETE&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">An&#225;lise de sensibilidade e especificidade das escalas de risco cardioemb&#243;lico</span><p id="par0110" class="elsevierStylePara elsevierViewall">Apresentamos agora o estudo da sensibilidade&#44; especificidade&#44; valor preditivo positivo e valor preditivo negativo das escalas de risco CHADS<span class="elsevierStyleInf">2</span> e CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc na <a class="elsevierStyleCrossRef" href="#tbl0015">Tabela 3</a> e <a class="elsevierStyleCrossRef" href="#fig0005">Figura 1</a>&#46; Na <a class="elsevierStyleCrossRef" href="#tbl0020">Tabela 4</a> apresentamos a an&#225;lise das escalas de risco cardioemb&#243;lico aplicadas na subpopula&#231;&#227;o de doentes n&#227;o anticoagulados &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>84&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discuss&#227;o</span><p id="par0115" class="elsevierStylePara elsevierViewall">O presente trabalho teve como principal objetivo avaliar a sensibilidade e especificidade das escalas de risco cardioemb&#243;lico CHADS<span class="elsevierStyleInf">2</span> e CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc como preditoras de fonte cardioemb&#243;lica numa popula&#231;&#227;o de doentes cerebrovasculares&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Neste estudo&#44; demonstr&#225;mos que a idade tem um peso determinante na presen&#231;a de cardioembolismo&#44; o que vai ao encontro dos resultados obtidos noutras investiga&#231;&#245;es desta &#225;rea<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> e reflete a import&#226;ncia refor&#231;ada deste fator na nova escala de risco CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc&#46; N&#227;o foi encontrada nenhuma associa&#231;&#227;o significativa entre os restantes fatores de risco e demogr&#225;ficos avaliados e a presen&#231;a de fonte cardioemb&#243;lica&#44; o que tamb&#233;m tem sido referenciado em publica&#231;&#245;es anteriores<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>&#46; O valor m&#233;dio de INR nos doentes previamente anticoagulados encontra-se em valores subterap&#234;uticos&#44; n&#227;o tendo sido verificada diferen&#231;a com significado estat&#237;stico entre os doentes com e sem fonte cardioemb&#243;lica documentada&#46; Este dado dever&#225; ser interpretado com precau&#231;&#227;o atendendo ao n&#250;mero reduzido da amostra de doentes previamente medicados com antivitam&#237;nicos K&#44; mas alerta para a necessidade cont&#237;nua de otimiza&#231;&#227;o posol&#243;gica&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">As vari&#225;veis utilizadas como indicadoras de fonte cardioemb&#243;lica encontram-se j&#225; identificadas por diversos autores<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;19&#44;20</span></a> como eficazes na predi&#231;&#227;o de fonte cardioemb&#243;lica em doentes com FA&#46; O facto de o ETE ser o exame com maior acuidade para a presen&#231;a de autocontraste espont&#226;neo na aur&#237;cula esquerda refor&#231;a a sua import&#226;ncia&#46; No entanto&#44; para doentes com FA e atendendo &#224;s indica&#231;&#245;es atuais da terap&#234;utica anticoagulante&#44; a Sociedade Europeia de Cardiologia n&#227;o aconselha a sua realiza&#231;&#227;o por rotina&#44; sugerindo-o apenas em circunst&#226;ncias particulares<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a>&#46; N&#227;o obstante&#44; na fase aguda do evento cerebrovascular&#44; o cl&#237;nico assistente necessita frequentemente de informa&#231;&#227;o segura do risco cardioemb&#243;lico para planear a cronologia de introdu&#231;&#227;o de terap&#234;utica antitromb&#243;tica para um doente em particular&#44; transformando os dados de ETE num complemento decisivo para essa decis&#227;o cl&#237;nica&#44; mesmo em doentes j&#225; com diagn&#243;stico pr&#233;vio de FA&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">A an&#225;lise das pontua&#231;&#245;es obtidas com a aplica&#231;&#227;o das escalas de risco cardioemb&#243;lico CHADS<span class="elsevierStyleInf">2</span> e CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc revela que estamos perante uma popula&#231;&#227;o cujo risco de ocorr&#234;ncia de novo AVC &#233; moderado ou elevado<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&#44; o que seria de esperar nesta popula&#231;&#227;o em particular&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Os resultados deste trabalho s&#227;o expl&#237;citos quanto &#224; validade destas duas classifica&#231;&#245;es &#40;CHADS<span class="elsevierStyleInf">2</span> e CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc&#41; na identifica&#231;&#227;o de risco cardioemb&#243;lico&#44; confirmando o seu valor mesmo em contexto de preven&#231;&#227;o secund&#225;ria cerebrovascular&#46; N&#227;o obstante&#44; a avalia&#231;&#227;o da sensibilidade e especificidade diferencial destas escalas revelou assimetrias&#46; Com efeito&#44; a classifica&#231;&#227;o mais recente parece ser mais sens&#237;vel na predi&#231;&#227;o de fonte cardioemb&#243;lica ativa&#44; mas menos espec&#237;fica do que a anterior&#44; n&#227;o se registando diferen&#231;as significativas em valores preditivos positivos ou negativos&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">V&#225;rios estudos demonstraram que os antivitam&#237;nicos K s&#227;o eficazes na preven&#231;&#227;o prim&#225;ria e secund&#225;ria de eventos cerebrovasculares&#59; no entanto&#44; est&#227;o tamb&#233;m associados a risco de complica&#231;&#245;es hemorr&#225;gicas&#44; bem como a uma taxa consider&#225;vel de abandono da terap&#234;utica<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&#46; Estas desvantagens contribuem para que a ades&#227;o &#224;s recomenda&#231;&#245;es internacionais&#44; no que respeita &#224; preven&#231;&#227;o de eventos tromboemb&#243;licos&#44; esteja longe do desej&#225;vel<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a>&#46; Novos f&#225;rmacos demonstraram possuir efic&#225;cia igual ou superior &#224; varfarina na preven&#231;&#227;o de acidentes cerebrovasculares&#44; implicando um menor risco hemorr&#225;gico e n&#227;o obrigando a controlo anal&#237;tico regular<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">25&#8211;28</span></a>&#46; Estes factos condicionam uma altera&#231;&#227;o da rela&#231;&#227;o risco-benef&#237;cio da terap&#234;utica antitromb&#243;tica profil&#225;tica na FA&#44; obrigando &#224; reconsidera&#231;&#227;o a curto prazo do ponto de corte para benef&#237;cio da prescri&#231;&#227;o de anticoagulante e indicando a necessidade de escalas de risco cardioemb&#243;lico com maior sensibilidade para predi&#231;&#227;o de eventos isqu&#233;micos&#46; Atendendo &#224;s caracter&#237;sticas da escala CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc indicadas neste trabalho&#44; esta parece apresentar um perfil mais &#250;til para esse fim&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Como principais limita&#231;&#245;es do nosso estudo&#44; identificamos o seu car&#225;ter unic&#234;ntrico e o facto de o ETE n&#227;o ser realizado imediatamente ap&#243;s o evento vascular&#44; permitindo&#44; assim&#44; a possibilidade de exist&#234;ncia pr&#233;via de trombos n&#227;o visualizados por este exame &#224; data da sua realiza&#231;&#227;o&#46; Refere-se ainda que o car&#225;ter frequentemente parox&#237;stico desta patologia implica que a aus&#234;ncia de fonte cardioemb&#243;lica documentada em determinado momento n&#227;o exclui a sua poss&#237;vel exist&#234;ncia anterior ou posterior&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conclus&#245;es</span><p id="par0150" class="elsevierStylePara elsevierViewall">Os resultados deste trabalho s&#227;o expl&#237;citos quanto &#224; validade das escalas de risco CHADS<span class="elsevierStyleInf">2</span> e CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc na identifica&#231;&#227;o de risco cardioemb&#243;lico em preven&#231;&#227;o secund&#225;ria cerebrovascular&#46; A nova escala CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc parece apresentar uma vantagem em rela&#231;&#227;o &#224; anterior classifica&#231;&#227;o pelo seu ganho em sensibilidade&#44; admitindo-se que a ligeira diminui&#231;&#227;o de especificidade desta escala&#44; &#224; luz das novas abordagens terap&#234;uticas&#44; n&#227;o parece traduzir nenhuma perda para a decis&#227;o m&#233;dica informada e individualizada&#44; sendo suplantada pelo seu ganho em sensibilidade&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Responsabilidades &#233;ticas</span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Prote&#231;&#227;o de pessoas e animais</span><p id="par0155" class="elsevierStylePara elsevierViewall">Os autores declaram que para esta investiga&#231;&#227;o n&#227;o se realizaram experi&#234;ncias em seres humanos e&#47;ou animais&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Confidencialidade dos dados</span><p id="par0160" class="elsevierStylePara elsevierViewall">Os autores declaram ter seguido os protocolos de seu centro de trabalho acerca da publica&#231;&#227;o dos dados de pacientes e que todos os pacientes inclu&#237;dos no estudo receberam informa&#231;&#245;es suficientes e deram o seu consentimento informado por escrito para participar nesse estudo&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Direito &#224; privacidade e consentimento escrito</span><p id="par0165" class="elsevierStylePara elsevierViewall">Os autores declaram que n&#227;o aparecem dados de pacientes neste artigo&#46;</p></span></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conflito de interesses</span><p id="par0170" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflito de interesses&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:12 [
        0 => array:2 [
          "identificador" => "xres251405"
          "titulo" => array:5 [
            0 => "Resumo"
            1 => "Introdu&#231;&#227;o e objetivos"
            2 => "M&#233;todos"
            3 => "Resultados"
            4 => "Conclus&#245;es"
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec239005"
          "titulo" => "Palavras-chave"
        ]
        2 => array:2 [
          "identificador" => "xres251406"
          "titulo" => array:5 [
            0 => "Abstract"
            1 => "Introduction and objectives"
            2 => "Methods"
            3 => "Results"
            4 => "Conclusions"
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec239004"
          "titulo" => "Keywords"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introdu&#231;&#227;o"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "M&#233;todos"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Materiais e popula&#231;&#227;o"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "An&#225;lise estat&#237;stica"
            ]
          ]
        ]
        6 => array:3 [
          "identificador" => "sec0025"
          "titulo" => "Resultados"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Popula&#231;&#227;o estudada"
            ]
            1 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Risco cardioemb&#243;lico e ecocardiograma transesof&#225;gico"
            ]
            2 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "An&#225;lise de sensibilidade e especificidade das escalas de risco cardioemb&#243;lico"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Discuss&#227;o"
        ]
        8 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Conclus&#245;es"
        ]
        9 => array:3 [
          "identificador" => "sec0055"
          "titulo" => "Responsabilidades &#233;ticas"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0060"
              "titulo" => "Prote&#231;&#227;o de pessoas e animais"
            ]
            1 => array:2 [
              "identificador" => "sec0065"
              "titulo" => "Confidencialidade dos dados"
            ]
            2 => array:2 [
              "identificador" => "sec0070"
              "titulo" => "Direito &#224; privacidade e consentimento escrito"
            ]
          ]
        ]
        10 => array:2 [
          "identificador" => "sec0075"
          "titulo" => "Conflito de interesses"
        ]
        11 => array:1 [
          "titulo" => "Bibliografia"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2012-07-02"
    "fechaAceptado" => "2012-09-12"
    "PalabrasClave" => array:2 [
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec239005"
          "palabras" => array:5 [
            0 => "Acidente vascular cerebral"
            1 => "Fibrilha&#231;&#227;o auricular"
            2 => "Tromboembolismo"
            3 => "Ecocardiografia"
            4 => "Anticoagula&#231;&#227;o"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec239004"
          "palabras" => array:5 [
            0 => "Stroke"
            1 => "Atrial fibrillation"
            2 => "Thromboembolism"
            3 => "Echocardiography"
            4 => "Anticoagulation"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introdu&#231;&#227;o e objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A cardioembolia representa uma das causas mais frequentes de les&#245;es cerebrovasculares isqu&#233;micas&#44; com preval&#234;ncia estimada de 20-30&#37; e implica&#231;&#245;es terap&#234;uticas diretas que obrigam &#224; sua correta avalia&#231;&#227;o&#46; Apesar de a valida&#231;&#227;o das escalas de risco cardioemb&#243;lico &#40;CHADS<span class="elsevierStyleInf">2</span> e&#44; mais recentemente&#44; CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc&#41; em popula&#231;&#245;es heterog&#233;neas de doentes com fibrilha&#231;&#227;o furicular&#44; desconhece-se ainda a sua validade em contexto de preven&#231;&#227;o secund&#225;ria cerebrovascular&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">&#201; objetivo deste trabalho estudar a sensibilidade e especificidade diferencial das escalas de risco cardioemb&#243;lico como preditoras de fonte cardioemb&#243;lica documentada por ecocardiograma transesof&#225;gico &#40;ETE&#41; numa popula&#231;&#227;o de doentes com AVC isqu&#233;mico&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Aplic&#225;mos as escalas CHADS<span class="elsevierStyleInf">2</span> e CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc a todos os doentes internados por evento cerebrovascular isqu&#233;mico na Unidade de AVC&#47;Enfermaria de Neurologia de um hospital central portugu&#234;s com diagn&#243;stico de fibrilha&#231;&#227;o auricular &#40;pr&#233;vio ou obtido durante&#47;ap&#243;s o internamento&#41;&#44; que realizaram ETE entre janeiro e agosto de 2011&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Definimos como presen&#231;a de fonte cardioemb&#243;lica a observa&#231;&#227;o em ETE de autocontraste espont&#226;neo na aur&#237;cula e ap&#234;ndice auricular esquerdo ou trombos nas cavidades card&#237;acas esquerdas&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Analis&#225;mos 94 doentes&#44; 66&#44;0&#37; do sexo masculino&#44; idade m&#233;dia&#58; 64&#44;4 anos &#40;desvio padr&#227;o&#58; 14&#44;2&#41;&#46; Foi detetada fonte cardioemb&#243;lica em 20 doentes&#46; A an&#225;lise de curva <span class="elsevierStyleItalic">Receiver Operating Characteristic</span> &#40;ROC&#41; identifica como preditores de fonte cardioemb&#243;lica pontua&#231;&#227;o CHADS<span class="elsevierStyleInf">2</span> &#8805;&#160;4&#59; sensibilidade&#58; 75&#44;0&#37;&#44; especificidade&#58; 66&#44;0&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;014 e pontua&#231;&#227;o CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc &#8805;&#160;5&#59; sensibilidade&#58; 83&#44;3&#37;&#44; especificidade&#58; 58&#44;0&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;009&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclus&#245;es</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Ambas as escalas apresentam sensibilidade significativa como preditoras de risco cardioemb&#243;lico em contexto de preven&#231;&#227;o secund&#225;ria cerebrovascular&#46; A escala CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc possui uma sensibilidade superior &#224; CHADS<span class="elsevierStyleInf">2</span>&#44; sendo&#44; no entanto&#44; menos espec&#237;fica&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introduction and objectives</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Cardioembolism is one of the most common causes of ischemic stroke&#44; with an estimated prevalence of 20-30&#37;&#44; and correct diagnosis is essential given the therapeutic implications&#46; Although stroke risk scores &#40;CHADS<span class="elsevierStyleInf">2</span> and more recently CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc&#41; have been validated in heterogeneous populations of patients with atrial fibrillation&#44; their accuracy has not been ascertained for secondary stroke prevention&#46; We set out to assess the sensitivity and specificity of the CHADS<span class="elsevierStyleInf">2</span> and CHA2DS<span class="elsevierStyleInf">2</span>-VASc stroke risk scores as predictors of cardioembolic sources&#44; documented by transesophageal echocardiography &#40;TEE&#41; in a population with ischemic stroke&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The CHADS<span class="elsevierStyleInf">2</span> and CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc scores were applied to all patients admitted to the stroke unit&#47;neurology ward of a Portuguese tertiary hospital with atrial fibrillation &#40;diagnosed previously or during or after admission&#41; who underwent TEE between January and August 2011&#46;</p><p id="spar0950" class="elsevierStyleSimplePara elsevierViewall">The presence of a cardioembolic source was defined as the observation by TEE of spontaneous echo contrast in the left atrium and atrial appendage or thrombi in the left cardiac chambers&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">We studied 94 patients&#44; 66&#46;0&#37; male&#44; mean age 64&#46;4 years &#40;standard deviation 14&#46;2&#41;&#46; A cardioembolic source was detected in 20 patients&#46; ROC curve analysis identified as predictors of cardioembolic source CHADS2 score &#8805;4 &#40;sensitivity of 75&#46;0&#37;&#44; specificity of 66&#46;0&#37;&#44; p&#61;0&#46;014&#41; and CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc score &#8805;5 &#40;sensitivity of 83&#46;3&#37;&#44; specificity of 58&#46;0&#37;&#44; p&#61;0&#46;009&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Both scores showed acceptable sensitivity as predictors of embolic risk in the context of secondary prevention of cardioembolic stroke&#46; The CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc score has higher sensitivity than CHADS<span class="elsevierStyleInf">2</span> but lower specificity&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:3 [
        "etiqueta" => "1"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Os 2 primeiros autores contribu&#237;ram de igual forma para a realiza&#231;&#227;o deste artigo&#46;</p>"
        "identificador" => "fn0005"
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2039
            "Ancho" => 1618
            "Tamanyo" => 103403
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Curva ROC representativa da sensibilidade e especificidade das escalas de risco cardioemb&#243;lico CHADS<span class="elsevierStyleInf">2</span> e CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc&#46; Os pontos representados indicam o valor de corte&#44; assumindo igual import&#226;ncia para sensibilidade e especificidade e correspondem a CHADS<span class="elsevierStyleInf">2</span> &#8805;&#160;4 e CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc &#8805;&#160;5&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabela 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">AP AVC&#58; antecedentes pessoais de acidente vascular cerebral&#59; CIA&#58; comunica&#231;&#227;o intrerauricular&#59; DM&#58; diabetes <span class="elsevierStyleItalic">mellitus</span>&#59; ETE&#58; ecocardiograma transesof&#225;gico&#59; FOP&#58; <span class="elsevierStyleItalic">foramen</span> oval patente&#59; HTA&#58; hipertens&#227;o arterial&#59; ICC&#58; insufici&#234;ncia card&#237;aca congestiva&#59; INR&#58; international normalized ratio&#46;</p><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Apresentam-se os valores de INR apenas para os doentes sob anticoagula&#231;&#227;o oral&#46; Data da realiza&#231;&#227;o do ETE apresentada em dias ap&#243;s o evento vascular&#46; As vari&#225;veis cont&#237;nuas foram apresentadas como m&#233;dia&#160;&#177;&#160;desvio padr&#227;o e as vari&#225;veis qualitativas como n&#250;mero absoluto &#40;&#37;&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Total de doentes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Aus&#234;ncia de fonte cardioemb&#243;lica &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>74&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Presen&#231;a de fonte cardioemb&#243;lica &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#44;4&#160;&#177;&#160;14&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&#44;3&#160;&#177;&#160;14&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#44;7&#160;&#177;&#160;5&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#160;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo &#40;masculino&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62 &#40;66&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;76&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;65&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;919&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alcoolismo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;9&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;8&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;15&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;364&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AP AVC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;6&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;5&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;10&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;337&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Coronariopatia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;11&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;13&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;5&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;439&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;9&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;10&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;5&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;666&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dislipidemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;31&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;33&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;25&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;421&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HTA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52 &#40;55&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;52&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;65&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;326&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ICC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;4&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;10&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;224&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tabagismo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;13&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;14&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;10&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Placas ateromatosas na aorta tor&#225;cica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32 &#40;34&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;32&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;40&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;345&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FOP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;8&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;9&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;5&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;402&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vegeta&#231;&#245;es valvulares&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;6&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;5&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;10&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;377&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CIA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;3&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;4&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;484&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Doen&#231;a valvular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;17&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;13&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;30&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;808&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Disfun&#231;&#227;o ventricular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;4&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;10&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;209&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Data da realiza&#231;&#227;o do ETE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;2&#160;&#177;&#160;1&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;1&#160;&#177;&#160;1&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;5&#160;&#177;&#160;0&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;391&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">INR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;91&#160;&#177;&#160;0&#44;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;95&#160;&#177;&#160;0&#44;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;85&#160;&#177;&#160;0&#44;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;752&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab354989.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Preval&#234;ncia de fatores de risco vascular na popula&#231;&#227;o em estudo</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">As pontua&#231;&#245;es das escalas est&#227;o apresentadas como mediana &#40;intervalo inter-quartis&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Fonte cardioemb&#243;lica ausente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Fonte cardioemb&#243;lica presente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CHADS<span class="elsevierStyleInf">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;00 &#40;3&#44;00-4&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;00 &#40;3&#44;25-4&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;00 &#40;3&#44;00-4&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;00 &#40;3&#44;00-5&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;00 &#40;5&#44;00-6&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;50 &#40;3&#44;00-5&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab354988.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Resultados da compara&#231;&#227;o entre as escalas de risco cardioemb&#243;lico e a presen&#231;a ou aus&#234;ncia de fonte cardioemb&#243;lica</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabela 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">ASC&#58; &#225;rea sob curva&#59; IC 95&#37;&#58; intervalo de confian&#231;a de 95&#37;&#59; VPN&#58; valor preditivo negativo&#59; VPP&#58; valor preditivo positivo&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Ponto de corte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Sensibilidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Especificidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">VPP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">VPN&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">ASC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CHADS<span class="elsevierStyleInf">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8805;&#160;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;720&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;587-0&#44;872&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8805;&#160;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;746&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;617-0&#44;874&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab354991.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Resultados do estudo da curva ROC para as escalas de risco cardioemb&#243;lico</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl0020"
        "etiqueta" => "Tabela 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">ASC&#58; &#225;rea sob curva&#59; IC 95&#37;&#58; intervalo de confian&#231;a de 95&#37;&#59; VPN&#58; valor preditivo pegativo&#59; VPP&#58; valor preditivo positivo&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Ponto de corte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Sensibilidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Especificidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">VPP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">VPN&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">ASC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CHADS<span class="elsevierStyleInf">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8805;&#160;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65&#44;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#44;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;746&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;579-0&#44;913&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;028&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8805;&#160;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56&#44;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;790&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;642-0&#44;937&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab354990.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Resultados do estudo da curva ROC para as escalas de risco cardioemb&#243;lico incluindo apenas os doentes n&#227;o anticoagulados &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>84&#41;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliografia"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:28 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology and risk factors of cerebral ischemia and ischemic heart diseases&#58; Similarities and differences"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46;P&#46; Soler"
                            1 => "V&#46;C&#46; Ruiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2174/157340310791658785"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Cardiol Rev"
                        "fecha" => "2010"
                        "volumen" => "6"
                        "paginaInicial" => "138"
                        "paginaFinal" => "149"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21804773"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prospective community-based study of stroke in Northern Portugal&#58; Incidence and case fatality in rural and urban populations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Correia"
                            1 => "M&#46;R&#46; Silva"
                            2 => "I&#46; Matos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.STR.0000137606.34301.13"
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "2004"
                        "volumen" => "35"
                        "paginaInicial" => "2048"
                        "paginaFinal" => "2053"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15256683"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Organisation for Economic Co-operation and Development&#46; Employment Labour and Social Affairs Committee&#46; Stroke care in OECD countries&#58; A comparison of treatment&#44; costs&#44; and outcomes in 17 countries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46; Moon"
                            1 => "P&#46; Moise"
                            2 => "S&#46; Jacobzone"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2003"
                        "editorial" => "Organisation for Economic Co-operation and Development&#44; Directorate for Employment&#44; Labour and Social Affairs&#44; Employment&#44; Labour and Social Affairs Committee"
                        "editorialLocalizacion" => "Paris"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology of ischemic stroke subtypes according to TOAST criteria&#58; Incidence&#44; recurrence&#44; and long-term survival in ischemic stroke subtypes&#58; A population-based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46;L&#46; Kolominsky-Rabas"
                            1 => "M&#46; Weber"
                            2 => "O&#46; Gefeller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "2001"
                        "volumen" => "32"
                        "paginaInicial" => "2735"
                        "paginaFinal" => "2740"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11739965"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Classification of subtype of acute ischemic stroke&#46; Definitions for use in a multicenter clinical trial&#46; TOAST&#46; Trial of Org 10172 in Acute Stroke Treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46;P&#46; Adams Jr"
                            1 => "B&#46;H&#46; Bendixen"
                            2 => "L&#46;J&#46; Kappelle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "1993"
                        "volumen" => "24"
                        "paginaInicial" => "35"
                        "paginaFinal" => "41"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7678184"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardioembolic stroke&#58; Clinical features&#44; specific cardiac disorders and prognosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Arboix"
                            1 => "J&#46; Ali&#243;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2174/157340310791658730"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Cardiol Rev"
                        "fecha" => "2010"
                        "volumen" => "6"
                        "paginaInicial" => "150"
                        "paginaFinal" => "161"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21804774"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology of atrial fibrillation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46; Bonhorst"
                            1 => "M&#46; Mendes"
                            2 => "J&#46; de Sousa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Port Cardiol"
                        "fecha" => "2010"
                        "volumen" => "29"
                        "paginaInicial" => "1207"
                        "paginaFinal" => "1217"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21072908"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "European stroke initiative recommendations for stroke management-update 2003"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46;S&#46; Olsen"
                            1 => "P&#46; Langhorne"
                            2 => "H&#46;C&#46; Diener"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cerebrovasc Dis"
                        "fecha" => "2003"
                        "volumen" => "16"
                        "paginaInicial" => "311"
                        "paginaFinal" => "337"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14584488"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antithrombotic medication for cardioembolic stroke prevention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;&#192;&#46; Font"
                            1 => "J&#46; Krupinski"
                            2 => "A&#46; Arboix"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4061/2011/607852"
                      "Revista" => array:5 [
                        "tituloSerie" => "Stroke Res Treat"
                        "fecha" => "2011"
                        "volumen" => "2011"
                        "paginaInicial" => "607852"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21822469"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of clinical classification schemes for predicting stroke&#58; Results from the National Registry of Atrial Fibrillation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46;F&#46; Gage"
                            1 => "A&#46;D&#46; Waterman"
                            2 => "W&#46; Shannon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2001"
                        "volumen" => "285"
                        "paginaInicial" => "2864"
                        "paginaFinal" => "2870"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11401607"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ACC&#47;AHA&#47;ESC guidelines for the management of patients with atrial fibrillation&#46; A report of the American College of Cardiology&#47;American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences &#40;Committee to develop guidelines for the management of patients with atrial fibrillation&#41; developed in collaboration with the North American Society of Pacing and Electrophysiology"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "American College of Cardiology&#59; American Heart Association&#59; European Society of Cardiology&#59; North American Society of Pacing and Electrophysiology"
                          "etal" => true
                          "autores" => array:3 [
                            0 => "V&#46; Fuster"
                            1 => "L&#46;E&#46; Ryd&#233;n"
                            2 => "R&#46;W&#46; Asinger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/euhj.2001.2983"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2001"
                        "volumen" => "22"
                        "paginaInicial" => "1852"
                        "paginaFinal" => "1923"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11601835"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improving stroke risk stratification using the CHADS<span class="elsevierStyleInf">2</span> and CHA<span class="elsevierStyleInf">2</span>DS<span class="elsevierStyleInf">2</span>-VASc risk scores in patients with paroxysmal atrial fibrillation by continuous arrhythmia burden monitoring"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Boriani"
                            1 => "G&#46;L&#46; Botto"
                            2 => "L&#46; Padeletti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/STROKEAHA.110.609297"
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "2011"
                        "volumen" => "42"
                        "paginaInicial" => "1768"
                        "paginaFinal" => "1770"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21493904"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antithrombotic therapy in cardiac embolism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Cervera"
                            1 => "A&#46; Chamorro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2174/157340310791658749"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Cardiol Rev"
                        "fecha" => "2010"
                        "volumen" => "6"
                        "paginaInicial" => "227"
                        "paginaFinal" => "237"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21804782"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recommendations for echocardiography use in the diagnosis and management of cardiac sources of embolism&#58; European Association of Echocardiography &#40;EAE&#41; &#40;a registered branch of the ESC&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Pepi"
                            1 => "A&#46; Evangelista"
                            2 => "P&#46; Nihoyannopoulos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ejechocard/jeq045"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Echocardiogr"
                        "fecha" => "2010"
                        "volumen" => "11"
                        "paginaInicial" => "461"
                        "paginaFinal" => "476"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20702884"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Possible refinement of clinical thromboembolism assessment in patients with atrial fibrillation using echocardiographic parameters"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Provid&#234;ncia"
                            1 => "A&#46; Botelho"
                            2 => "J&#46; Trigo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/europace/eur272"
                      "Revista" => array:6 [
                        "tituloSerie" => "Europace"
                        "fecha" => "2012"
                        "volumen" => "14"
                        "paginaInicial" => "36"
                        "paginaFinal" => "45"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21868410"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach&#58; The euro heart survey on atrial fibrillation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46;Y&#46; Lip"
                            1 => "R&#46; Nieuwlaat"
                            2 => "R&#46; Pisters"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.09-1584"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2010"
                        "volumen" => "137"
                        "paginaInicial" => "263"
                        "paginaFinal" => "272"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19762550"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ischaemic stroke subtypes and associated risk factors&#58; A French population based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "Y&#46; Bejot"
                            1 => "M&#46; Caillier"
                            2 => "D&#46; Ben Salem"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jnnp.2008.150318"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "2008"
                        "volumen" => "79"
                        "paginaInicial" => "1344"
                        "paginaFinal" => "1348"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18586864"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk factors in various subtypes of ischemic stroke according to TOAST criteria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "N&#46; Aquil"
                            1 => "I&#46; Begum"
                            2 => "A&#46; Ahmed"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "05.2011/JCPSP.280283"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Coll Physicians Surg Pak"
                        "fecha" => "2011"
                        "volumen" => "21"
                        "paginaInicial" => "280"
                        "paginaFinal" => "283"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21575535"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mild left ventricular dysfunction is associated with thrombogenicity in cardioembolic stroke"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46;M&#46; Kwon"
                            1 => "J&#46;H&#46; Park"
                            2 => "J&#46;M&#46; Kim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000096489"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Neurol"
                        "fecha" => "2006"
                        "volumen" => "56"
                        "paginaInicial" => "217"
                        "paginaFinal" => "221"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17057381"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Importance of left atrial appendage flow as a predictor of thromboembolic events in patients with atrial fibrillation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "O&#46; Kamp"
                            1 => "P&#46;M&#46; Verhorst"
                            2 => "R&#46;C&#46; Welling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/euhj.1998.1453"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "1999"
                        "volumen" => "20"
                        "paginaInicial" => "979"
                        "paginaFinal" => "985"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10361051"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recommendations for transoesophageal echocardiography&#58; Update 2010"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "F&#46;A&#46; Flachskampf"
                            1 => "L&#46; Badano"
                            2 => "W&#46;G&#46; Daniel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ejechocard/jeq057"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Echocardiogr"
                        "fecha" => "2010"
                        "volumen" => "11"
                        "paginaInicial" => "557"
                        "paginaFinal" => "576"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20688767"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guidelines for the management of atrial fibrillation&#58; the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology &#40;ESC&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;J&#46; Camm"
                            1 => "P&#46; Kirchhof"
                            2 => "G&#46;Y&#46; Lip"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurheartj/ehq278"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2010"
                        "volumen" => "31"
                        "paginaInicial" => "2369"
                        "paginaFinal" => "2429"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20802247"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antithrombotic therapy in nonvalvular atrial fibrillation&#58; A narrative review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;P&#46; S&#225;"
                            1 => "R&#46;P&#46; Rodrigues"
                            2 => "J&#46; Santos-Antunes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.repc.2011.09.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Port Cardiol"
                        "fecha" => "2011"
                        "volumen" => "30"
                        "paginaInicial" => "905"
                        "paginaFinal" => "924"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22094310"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Atrial fibrillation and thromboembolic risk&#58; What is the extent of adherence to guidelines in clinical practice&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46; Dores"
                            1 => "R&#46; Cardiga"
                            2 => "R&#46; Ferreira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Port Cardiol"
                        "fecha" => "2011"
                        "volumen" => "30"
                        "paginaInicial" => "171"
                        "paginaFinal" => "180"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21553610"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dabigatran versus warfarin in patients with atrial fibrillation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;J&#46; Connolly"
                            1 => "M&#46;D&#46; Ezekowitz"
                            2 => "S&#46; Yusuf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa0905561"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2009"
                        "volumen" => "361"
                        "paginaInicial" => "1139"
                        "paginaFinal" => "1151"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19717844"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Apixaban in patients with atrial fibrillation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;J&#46; Connolly"
                            1 => "J&#46; Eikelboom"
                            2 => "C&#46; Joyner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa1007432"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2011"
                        "volumen" => "364"
                        "paginaInicial" => "806"
                        "paginaFinal" => "817"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21309657"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rivaroxaban-once daily&#44; oral&#44; direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation&#58; Rationale and design of the ROCKET AF study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "ROCKET AF Study Investigators"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ahj.2009.11.025"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "2010"
                        "volumen" => "159"
                        "paginaInicial" => "340"
                        "paginaFinal" => "347"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20211293"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparative efficacy and safety of the novel oral anticoagulants dabigatran&#44; rivaroxaban and apixaban in preclinical and clinical development"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Ufer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1160/TH09-09-0659"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thromb Haemost"
                        "fecha" => "2010"
                        "volumen" => "103"
                        "paginaInicial" => "572"
                        "paginaFinal" => "585"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20135071"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "pt"
  "url" => "/08702551/0000003200000005/v1_201308021350/S0870255113000383/v1_201308021350/pt/main.assets"
  "Apartado" => array:4 [
    "identificador" => "358"
    "tipo" => "SECCION"
    "pt" => array:2 [
      "titulo" => "Artigos originais"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "pt"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08702551/0000003200000005/v1_201308021350/S0870255113000383/v1_201308021350/pt/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255113000383?idApp=UINPBA00004E"
]