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and left ventricular dilatation&#44; but with normal systolic function&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">To exclude coronary artery disease and simultaneously to evaluate the rest of the thoracic aorta&#44; cardiac computed tomography &#40;CT&#41; was performed &#40;including the thoracic aorta&#41;&#46; This exam ruled out coronary artery disease &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41; and confirmed the presence of significant aortic root dilatation &#40;70 mm&#41;&#44; the rest of the aorta being normal &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The patient was referred for surgery&#44; with no need for invasive catheterization&#46; He underwent a Bentall procedure with implantation of an aortic conduit and a prosthetic aortic valve &#40;29 mm St&#46; Jude&#41;&#46; There were no complications after surgery&#44; the echocardiogram showing the prosthetic aortic valve with normal motion and the conduit functioning correctly&#46; The patient was discharged six days later and warfarin was added to his medication&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">At 6-month follow-up the patient was asymptomatic and free from cardiovascular events&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Marfan syndrome is the most common inherited multisystemic disorder of connective tissue&#44; with a reported incidence of 2-3 per 10<span class="elsevierStyleHsp" style=""></span>000 population&#44; without gender&#44; racial&#44; or ethnic predilection&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Its cardiovascular features were first outlined by McKusick in 1955<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#59; according to the current diagnostic criteria major cardiovascular manifestations include dilatation of the ascending aorta&#44; with or without dissection&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In the presence of ascending aorta dilatation&#44; prophylactic surgery is recommended when the diameter of the ascending aorta at the aortic sinuses reaches 4&#46;5 cm&#44; or in some cases even less &#40;when there is a family history of aortic dissection&#44; in the presence of rapid aortic dilatation or severe aortic valve regurgitation&#44; or when a valve-sparing operation is possible&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In the case reported&#44; the presence of severe aortic root dilatation &#40;&#62;60 mm&#41; with associated aortic valve regurgitation was a clear indication for surgery&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Although the patient had no angina&#44; obstructive coronary artery disease was ruled out prior to aortic surgery&#46; This evaluation should be performed in asymptomatic male patients over the age of 40 or postmenopausal women&#44; and is also indicated for patients with previous coronary artery disease&#44; symptoms of left ventricular dysfunction&#44; presumed ischemic mitral regurgitation or one or more cardiovascular risk factor&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Traditionally&#44; the study of coronary artery anatomy is performed through invasive angiography&#46; However&#44; this can also be safely done with cardiac CT<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> taking advantage of the high negative predictive value of this exam<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#59; this is one indication for which cardiac CT can replace invasive angiography&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">This approach can be applied to a high percentage of patients when study of coronary artery anatomy is indicated prior to valvular or aortic surgery&#44; as it is more convenient and less invasive than invasive coronary angiography&#46; Furthermore&#44; some patient subsets may derive greater benefit from this approach&#44; when there is higher iatrogenic potential &#40;such as in the presence of aortic dissection or aortic valve thrombus&#47;vegetations&#41; or when coronary catheterization would be difficult &#40;such as in the presence of aortic root dilatation or anomalous coronary artery origin&#41;&#46; In these cases&#44; cardiac CT&#44; avoiding the need for potential prolonged invasive cardiac catheterization&#44; reduces not only radiation and contrast doses&#44; but also the risk of complications&#46; Among the latter&#44; aortic dissection has been described as a rare &#40;0&#46;04&#37;&#41; but serious complication of cardiac catheterization and was found to be associated with the use of non-conventional catheters&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The risk of contrast-induced nephropathy should be weighed when coronary angiography is considered&#46; 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Case report
Marfan syndrome with ascending aortic aneurysm: Value of cardiac computed tomography
Síndrome de Marfan com aneurisma da aorta ascendente – importância da angioTC cardíaca
Pedro Jerónimo Sousaa,
Autor para correspondência
p965675551@gmail.com

Corresponding author.
, Pedro Araújo Gonçalvesc,d, Sérgio Boshoffb, Hugo Marquesc, Salomé Carvalhoa, João Moradas Ferreirab, Miguel Mota Carmod, Ana Aleixod, José Pedro Nevesb, Miguel Mendesa
a Serviço de Cardiologia, Hospital de Santa Cruz – Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal
b Cirurgia Cardio-Torácica, Hospital de Santa Cruz – Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal
c Centro de Imagiologia, Hospital da Luz, Lisboa, Portugal
d CEDOC – Centro de Estudos de doenças Crónicas – FCM-UNL, Lisboa, Portugal
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case report</span><p id="par0005" class="elsevierStylePara elsevierViewall">We report the case of a 40-year-old man with no known cardiovascular risk factors who was diagnosed with Marfan syndrome at the age of 32&#46; His medical history included gastroesophageal reflux syndrome and previous ophthalmic surgery for lens dislocation and orthopedic surgery on the tibial-tarsal joints&#46; He was being medicated with bisoprolol and pantoprazole&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">For the previous six months he had presented worsening exercise dyspnea and had marked limitation in activity due to symptoms &#40;NYHA class II&#8211;III&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The echocardiogram showed severe aortic valve regurgitation secondary to significant aortic root dilatation &#40;64 mm diameter at the Valsalva sinus&#41; and left ventricular dilatation&#44; but with normal systolic function&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">To exclude coronary artery disease and simultaneously to evaluate the rest of the thoracic aorta&#44; cardiac computed tomography &#40;CT&#41; was performed &#40;including the thoracic aorta&#41;&#46; This exam ruled out coronary artery disease &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41; and confirmed the presence of significant aortic root dilatation &#40;70 mm&#41;&#44; the rest of the aorta being normal &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The patient was referred for surgery&#44; with no need for invasive catheterization&#46; He underwent a Bentall procedure with implantation of an aortic conduit and a prosthetic aortic valve &#40;29 mm St&#46; Jude&#41;&#46; There were no complications after surgery&#44; the echocardiogram showing the prosthetic aortic valve with normal motion and the conduit functioning correctly&#46; The patient was discharged six days later and warfarin was added to his medication&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">At 6-month follow-up the patient was asymptomatic and free from cardiovascular events&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Marfan syndrome is the most common inherited multisystemic disorder of connective tissue&#44; with a reported incidence of 2-3 per 10<span class="elsevierStyleHsp" style=""></span>000 population&#44; without gender&#44; racial&#44; or ethnic predilection&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Its cardiovascular features were first outlined by McKusick in 1955<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#59; according to the current diagnostic criteria major cardiovascular manifestations include dilatation of the ascending aorta&#44; with or without dissection&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In the presence of ascending aorta dilatation&#44; prophylactic surgery is recommended when the diameter of the ascending aorta at the aortic sinuses reaches 4&#46;5 cm&#44; or in some cases even less &#40;when there is a family history of aortic dissection&#44; in the presence of rapid aortic dilatation or severe aortic valve regurgitation&#44; or when a valve-sparing operation is possible&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In the case reported&#44; the presence of severe aortic root dilatation &#40;&#62;60 mm&#41; with associated aortic valve regurgitation was a clear indication for surgery&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Although the patient had no angina&#44; obstructive coronary artery disease was ruled out prior to aortic surgery&#46; This evaluation should be performed in asymptomatic male patients over the age of 40 or postmenopausal women&#44; and is also indicated for patients with previous coronary artery disease&#44; symptoms of left ventricular dysfunction&#44; presumed ischemic mitral regurgitation or one or more cardiovascular risk factor&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Traditionally&#44; the study of coronary artery anatomy is performed through invasive angiography&#46; However&#44; this can also be safely done with cardiac CT<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> taking advantage of the high negative predictive value of this exam<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#59; this is one indication for which cardiac CT can replace invasive angiography&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">This approach can be applied to a high percentage of patients when study of coronary artery anatomy is indicated prior to valvular or aortic surgery&#44; as it is more convenient and less invasive than invasive coronary angiography&#46; Furthermore&#44; some patient subsets may derive greater benefit from this approach&#44; when there is higher iatrogenic potential &#40;such as in the presence of aortic dissection or aortic valve thrombus&#47;vegetations&#41; or when coronary catheterization would be difficult &#40;such as in the presence of aortic root dilatation or anomalous coronary artery origin&#41;&#46; In these cases&#44; cardiac CT&#44; avoiding the need for potential prolonged invasive cardiac catheterization&#44; reduces not only radiation and contrast doses&#44; but also the risk of complications&#46; Among the latter&#44; aortic dissection has been described as a rare &#40;0&#46;04&#37;&#41; but serious complication of cardiac catheterization and was found to be associated with the use of non-conventional catheters&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The risk of contrast-induced nephropathy should be weighed when coronary angiography is considered&#46; Since there are no differences in the contrast dose used in coronary angiography performed invasively or by cardiac CT&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> this risk should be similar with both techniques&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In the case reported&#44; there were two risk factors for complications with invasive coronary angiography&#58; the presence of aortic root dilatation and severe aortic valve regurgitation&#46; This favored the choice of cardiac CT to study the cardiac anatomy&#44; which was safe&#44; ruled out coronary artery disease and simultaneously provided detailed anatomy of the thoracic aorta&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Protection of human and animal subjects</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Confidentiality of data</span><p id="par0095" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data and that all the patients included in the study received sufficient information and gave their written informed consent to participate in the study&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Right to privacy and informed consent</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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Informação do artigo
ISSN: 08702551
Idioma original: Inglês
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Ano/Mês Html Pdf Total
2024 Novembro 10 7 17
2024 Outubro 65 39 104
2024 Setembro 65 23 88
2024 Agosto 58 32 90
2024 Julho 45 36 81
2024 Junho 36 27 63
2024 Maio 50 32 82
2024 Abril 46 41 87
2024 Maro 34 32 66
2024 Fevereiro 38 22 60
2024 Janeiro 26 26 52
2023 Dezembro 30 39 69
2023 Novembro 69 42 111
2023 Outubro 74 15 89
2023 Setembro 44 29 73
2023 Agosto 38 23 61
2023 Julho 24 19 43
2023 Junho 32 16 48
2023 Maio 38 31 69
2023 Abril 33 6 39
2023 Maro 40 22 62
2023 Fevereiro 31 27 58
2023 Janeiro 33 15 48
2022 Dezembro 45 31 76
2022 Novembro 45 30 75
2022 Outubro 35 23 58
2022 Setembro 29 41 70
2022 Agosto 41 30 71
2022 Julho 39 38 77
2022 Junho 17 24 41
2022 Maio 22 26 48
2022 Abril 28 35 63
2022 Maro 19 35 54
2022 Fevereiro 18 14 32
2022 Janeiro 26 18 44
2021 Dezembro 18 32 50
2021 Novembro 47 38 85
2021 Outubro 38 36 74
2021 Setembro 24 33 57
2021 Agosto 38 29 67
2021 Julho 28 23 51
2021 Junho 21 19 40
2021 Maio 27 27 54
2021 Abril 38 37 75
2021 Maro 61 14 75
2021 Fevereiro 66 24 90
2021 Janeiro 40 13 53
2020 Dezembro 39 10 49
2020 Novembro 39 11 50
2020 Outubro 23 13 36
2020 Setembro 43 8 51
2020 Agosto 19 11 30
2020 Julho 41 7 48
2020 Junho 40 7 47
2020 Maio 42 4 46
2020 Abril 59 12 71
2020 Maro 32 8 40
2020 Fevereiro 46 29 75
2020 Janeiro 29 15 44
2019 Dezembro 40 24 64
2019 Novembro 34 6 40
2019 Outubro 30 8 38
2019 Setembro 29 14 43
2019 Agosto 28 2 30
2019 Julho 42 15 57
2019 Junho 33 15 48
2019 Maio 44 23 67
2019 Abril 29 32 61
2019 Maro 32 23 55
2019 Fevereiro 35 23 58
2019 Janeiro 17 4 21
2018 Dezembro 41 11 52
2018 Novembro 102 7 109
2018 Outubro 206 30 236
2018 Setembro 85 17 102
2018 Agosto 65 15 80
2018 Julho 68 13 81
2018 Junho 87 4 91
2018 Maio 130 10 140
2018 Abril 132 10 142
2018 Maro 140 10 150
2018 Fevereiro 96 8 104
2018 Janeiro 126 4 130
2017 Dezembro 127 8 135
2017 Novembro 72 6 78
2017 Outubro 59 9 68
2017 Setembro 43 7 50
2017 Agosto 52 8 60
2017 Julho 41 11 52
2017 Junho 62 14 76
2017 Maio 77 17 94
2017 Abril 52 8 60
2017 Maro 50 9 59
2017 Fevereiro 78 7 85
2017 Janeiro 35 7 42
2016 Dezembro 29 12 41
2016 Novembro 26 5 31
2016 Outubro 56 15 71
2016 Setembro 45 14 59
2016 Agosto 25 7 32
2016 Julho 10 3 13
2016 Junho 3 5 8
2016 Maio 17 5 22
2016 Abril 62 3 65
2016 Maro 90 11 101
2016 Fevereiro 109 24 133
2016 Janeiro 93 15 108
2015 Dezembro 90 11 101
2015 Novembro 88 10 98
2015 Outubro 91 13 104
2015 Setembro 104 13 117
2015 Agosto 101 18 119
2015 Julho 142 6 148
2015 Junho 77 2 79
2015 Maio 96 8 104
2015 Abril 80 10 90
2015 Maro 91 5 96
2015 Fevereiro 74 4 78
2015 Janeiro 69 9 78
2014 Dezembro 75 8 83
2014 Novembro 77 12 89
2014 Outubro 92 12 104
2014 Setembro 113 21 134
2014 Agosto 97 9 106
2014 Julho 98 15 113
2014 Junho 87 5 92
2014 Maio 92 9 101
2014 Abril 73 11 84
2014 Maro 150 18 168
2014 Fevereiro 127 11 138
2014 Janeiro 134 18 152
2013 Dezembro 113 14 127
2013 Novembro 122 26 148
2013 Outubro 106 17 123
2013 Setembro 95 22 117
2013 Agosto 104 16 120
2013 Julho 585 23 608
2013 Junho 189 29 218
2013 Maio 99 24 123
2013 Abril 101 43 144
2013 Maro 106 28 134
2013 Fevereiro 92 34 126
2013 Janeiro 45 33 78
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