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o modo de reperfus&#227;o escolhido&#44; a mortalidade intra-hospitalar aumenta de 3&#44;0 para 4&#44;8&#37; quando o tempo &#171;porta-bal&#227;o&#187; passa de 30 para 180<span class="elsevierStyleHsp" style=""></span>min<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> e a mortalidade aos 12 meses aumenta 7&#44;5&#37; a cada 30<span class="elsevierStyleHsp" style=""></span>min de atraso<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Manter o menor intervalo de tempo desde o in&#237;cio dos sintomas at&#233; &#224; reperfus&#227;o &#233; real&#231;ado nas <span class="elsevierStyleItalic">guidelines</span> atuais como uma prioridade&#46; A Sociedade Europeia de Cardiologia sugere uma reperfus&#227;o por ICP prim&#225;ria t&#227;o precoce quanto poss&#237;vel em doentes com EAMEST que se apresentem nas primeiras 12<span class="elsevierStyleHsp" style=""></span>h do in&#237;cio dos sintomas e que mantenham eleva&#231;&#227;o do segmento ST &#40;ou bloqueio completo de ramo esquerdo presumivelmente de novo&#41; no electrocardiograma &#40;ECG&#41; de 12 deriva&#231;&#245;es &#40;recomenda&#231;&#227;o classe <span class="elsevierStyleSmallCaps">i</span>&#44; n&#237;vel de evid&#234;ncia A&#41;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46; O tempo recomendado desde o primeiro contacto m&#233;dico at&#233; &#224; ICP prim&#225;ria deve ser &#8804; 2<span class="elsevierStyleHsp" style=""></span>h em qualquer EAMEST e &#8804; 90<span class="elsevierStyleHsp" style=""></span>min em doentes que se apresentem com menos de 2<span class="elsevierStyleHsp" style=""></span>h desde o in&#237;cio dos sintomas&#44; com EAMEST anterior extenso e com baixo risco hemorr&#225;gico &#40;recomenda&#231;&#227;o classe <span class="elsevierStyleSmallCaps">i</span>&#44; n&#237;vel de evid&#234;ncia B&#41;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Igualmente&#44; as recomenda&#231;&#245;es do <span class="elsevierStyleItalic">American College of Cardiology</span> preconizam que os doentes com EAMEST que recorram aos hospitais com capacidade de realizar ICP prim&#225;ria devam ser tratados em 90<span class="elsevierStyleHsp" style=""></span>min ap&#243;s o primeiro contacto m&#233;dico &#40;recomenda&#231;&#227;o classe <span class="elsevierStyleSmallCaps">i</span>&#44; n&#237;vel de evid&#234;ncia A&#41;&#44; n&#227;o devendo o tempo total de isqu&#233;mia ultrapassar os 120<span class="elsevierStyleHsp" style=""></span>min<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Adicionalmente&#44; dada a import&#226;ncia do ECG de 12 deriva&#231;&#245;es neste contexto&#44; este deve ser obtido em menos de 10<span class="elsevierStyleHsp" style=""></span>min&#44; desde o primeiro contacto m&#233;dico&#44; em doentes que apresentem desconforto tor&#225;cico<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#46; Recomenda&#231;&#245;es semelhantes foram adotadas por sociedades nacionais&#46; Em Portugal &#233; indicado que o atraso na transfer&#234;ncia de doentes para um centro com capacidade de realizar ICP prim&#225;ria n&#227;o deve exceder os 30<span class="elsevierStyleHsp" style=""></span>min<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">O objetivo deste trabalho foi analisar a adequa&#231;&#227;o do tratamento dos doentes com EAMEST submetidos a ICP prim&#225;ria num centro terci&#225;rio&#44; examinando os tempos decorridos nas diferentes fases da abordagem dos doentes com enfarte at&#233; &#224; ICP prim&#225;ria&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="par0030" class="elsevierStylePara elsevierViewall">Com base no registo prospetivo &#40;<span class="elsevierStyleItalic">Angioplasty and Coronary Revascularization On Santa Cruz Hospital</span>&#41; &#40;ACROSS&#41; que inclui todos os doentes consecutivos submetidos a ICP num &#250;nico centro de interven&#231;&#227;o terci&#225;rio desde 2002&#44; selecionamos no per&#237;odo compreendido entre 2003 e 2007&#44; 223 doentes consecutivos com EAMEST submetidos a ICP prim&#225;ria&#46; O diagn&#243;stico de EAMEST foi estabelecido em doentes com dor tor&#225;cica aguda com dura&#231;&#227;o superior a 30<span class="elsevierStyleHsp" style=""></span>min e eleva&#231;&#227;o do segmento ST em pelo menos 2 deriva&#231;&#245;es cont&#237;guas no ECG de 12 deriva&#231;&#245;es ou com bloqueio completo de ramo esquerdo de novo&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Os tempos totais e intercalares desde o in&#237;cio dos sintomas at&#233; &#224; realiza&#231;&#227;o da ICP prim&#225;ria foram analisados e comparados com as recomenda&#231;&#245;es&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Os intervalos de tempo foram definidos prospetivamente e comparados com os recomendados do seguinte modo&#58; <span class="elsevierStyleItalic">dor-m&#233;dico</span> - desde o in&#237;cio dos sintomas at&#233; ao primeiro contacto m&#233;dico &#40;tempo recomendado &#40;TR&#41; - desde o primeiro contacto m&#233;dico at&#233; &#224; realiza&#231;&#227;o do ECG diagn&#243;stico &#40;TR &#60; 10<span class="elsevierStyleHsp" style=""></span>min&#41;&#59; <span class="elsevierStyleItalic">ECG-centro ICP</span>&#44; desde a realiza&#231;&#227;o do ECG diagn&#243;stico at&#233; &#224; chegada ao centro com capacidade de ICP &#40;TR &#60; 30<span class="elsevierStyleHsp" style=""></span>min&#41;&#59; <span class="elsevierStyleItalic">centro ICP-dispositivo</span>&#44; desde a chegada ao centro com capacidade para ICP at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o &#40;TR &#60; 50<span class="elsevierStyleHsp" style=""></span>min&#41;&#59; <span class="elsevierStyleItalic">ECG-dispositivo</span>&#44; desde a realiza&#231;&#227;o do ECG diagn&#243;stico at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o &#40;TR &#60; 80<span class="elsevierStyleHsp" style=""></span>min&#41;&#59; <span class="elsevierStyleItalic">m&#233;dico-dispositivo</span>&#44; desde o primeiro contacto m&#233;dico at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o &#40;TR &#60; 90<span class="elsevierStyleHsp" style=""></span>min&#41;&#59; e <span class="elsevierStyleItalic">tempo total de isqu&#233;mia</span>&#44; desde o in&#237;cio dos sintomas at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o &#40;TR &#60; 120<span class="elsevierStyleHsp" style=""></span>min&#41;&#46; Estes limites de tempo foram definidos segundo recomenda&#231;&#245;es nacionais e internacionais<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;7</span></a>&#46; A popula&#231;&#227;o foi dividida em 3 grupos&#44; de acordo com a sua origem&#58; Hospital A &#40;a 6<span class="elsevierStyleHsp" style=""></span>km de dist&#226;ncia do nosso centro&#41;&#44; Hospital B &#40;a 22<span class="elsevierStyleHsp" style=""></span>km de dist&#226;ncia do nosso centro&#41; e sistema de emerg&#234;ncia pr&#233;-hospitalar&#46; Os intervalos de tempo avaliados foram comparados entre estes grupos&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Foram avaliados ainda os seguintes par&#226;metros relacionados com a perfus&#227;o mioc&#225;rdica&#58; o fluxo TIMI&#44; o <span class="elsevierStyleItalic">TIMI frame count</span> e a resolu&#231;&#227;o do segmento ST ap&#243;s a ICP&#46; O fluxo TIMI e o <span class="elsevierStyleItalic">TIMI frame count</span> foram calculados de acordo com refer&#234;ncias publicadas<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a>&#46; A resolu&#231;&#227;o do segmento ST foi calculada com a soma de todas as deriva&#231;&#245;es que apresentavam eleva&#231;&#227;o ST no ECG diagn&#243;stico&#46; Estas vari&#225;veis foram usadas como marcadores indiretos do sucesso da ICP do seguinte modo&#58; fluxo TIMI 3&#44; <span class="elsevierStyleItalic">TIMI frame count</span> &#8804; 24 e resolu&#231;&#227;o do segmento ST &#8805;70&#37;&#46; Foram comparadas diferen&#231;as no tempo total de isqu&#233;mia na presen&#231;a e aus&#234;ncia destes marcadores indiretos de sucesso da ICP&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lise estat&#237;stica</span><p id="par0050" class="elsevierStylePara elsevierViewall">As vari&#225;veis categ&#243;ricas apresentam-se como n&#250;mero &#47; percentagem&#46; As vari&#225;veis cont&#237;nuas s&#227;o apresentadas como m&#233;dia &#177; desvio padr&#227;o&#44; exceto para os valores temporais&#44; que se apresentam como mediana&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Diferen&#231;as entre vari&#225;veis cont&#237;nuas foram testadas usando o teste de Mann-Whitney ou de Kruskal-Wallis&#46; As diferen&#231;as observadas foram consideradas significativas quando p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 &#40;intervalo de confian&#231;a 0&#44;95&#41;&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Resultados</span><p id="par0060" class="elsevierStylePara elsevierViewall">Na popula&#231;&#227;o selecionada de 223 doentes&#44; a idade m&#233;dia foi 60<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 anos&#44; com 76&#37; de doentes do sexo masculino&#46; Os fatores de risco cardiovasculares presentes eram&#58; diabetes em 17&#37; dos doentes&#44; tabagismo &#40;ativo ou antigo&#41; em 56&#37;&#44; hipertens&#227;o em 55&#37; e dislipid&#233;mia em 50&#37;&#46; Na apresenta&#231;&#227;o 7&#37; tinham uma classe de Killip-Kimball &#8805;<span class="elsevierStyleHsp" style=""></span>3 e 18&#37; dos doentes tinham antecedentes de enfarte do mioc&#225;rdio&#44; 19&#37; de ICP&#44; 4&#37; de cirurgia de revasculariza&#231;&#227;o mioc&#225;rdica&#44; 5&#37; de doen&#231;a cerebrovascular e 2&#37; apresentavam insufici&#234;ncia renal com necessidade de di&#225;lise&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Os intervalos de tempo totais e intercalares apresentam-se na <a class="elsevierStyleCrossRef" href="#tbl0005">Tabela 1</a> e <a class="elsevierStyleCrossRef" href="#fig0005">Figura 1</a>&#46; A mediana do tempo total de isqu&#233;mia foi 4<span class="elsevierStyleHsp" style=""></span>h 30<span class="elsevierStyleHsp" style=""></span>min&#44; sendo que apenas 4&#37; realizaram a ICP em menos de 120<span class="elsevierStyleHsp" style=""></span>min&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Os intervalos com menor atraso foram o intervalo m&#233;dico-ECG&#44; com uma mediana de 8<span class="elsevierStyleHsp" style=""></span>min &#40;&#60;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>min em 59&#37; dos doentes&#41; e centro ICP-dispositivo&#44; com uma mediana de 30<span class="elsevierStyleHsp" style=""></span>min &#40;&#60;<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>min em 75&#37; dos doentes&#41;&#46; Os intervalos com maior atraso foram o intervalo dor-m&#233;dico&#44; com uma mediana de 104<span class="elsevierStyleHsp" style=""></span>min &#40;&#60; 30<span class="elsevierStyleHsp" style=""></span>min em 6&#37; dos doentes&#41; e m&#233;dico-dispositivo com mediana de 140 min &#40;&#60;<span class="elsevierStyleHsp" style=""></span>90<span class="elsevierStyleHsp" style=""></span>min em 16&#37; dos doentes&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">A origem mais frequente foi o Hospital A &#40;64&#37;&#41;&#44; seguida do Hospital B &#40;15&#37;&#41; e sistema de emerg&#234;ncia pr&#233;-hospitalar &#40;9&#37;&#41;&#46; Os restantes 12&#37; provieram de outras institui&#231;&#245;es de sa&#250;de ou recorreram diretamente ao nosso centro pelos seus pr&#243;prios meios&#46; Os tempos totais e intercalares de cada grupo apresentam-se na <a class="elsevierStyleCrossRef" href="#tbl0010">Tabela 2</a> e <a class="elsevierStyleCrossRef" href="#fig0010">Figura 2</a>&#46; O grupo pr&#233;-hospitalar obteve menor tempo total de isqu&#233;mia que o Hospital A ou B &#40;2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>45<span class="elsevierStyleHsp" style=""></span>min <span class="elsevierStyleItalic">versus</span> 4<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>44<span class="elsevierStyleHsp" style=""></span>h e 6<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>min&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Esta diferen&#231;a resultou principalmente de um tempo dor-m&#233;dico menor &#40;75 <span class="elsevierStyleItalic">versus</span> 107 e 152<span class="elsevierStyleHsp" style=""></span>min&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; e ECG-centro ICP tamb&#233;m menor &#40;36 <span class="elsevierStyleItalic">versus</span> 106 e 99<span class="elsevierStyleHsp" style=""></span>min&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Do total da amostra&#44; 203 doentes n&#227;o foram referenciados diretamente pelo sistema de emerg&#234;ncia pr&#233;-hospitalar para o nosso centro&#46; Neste grupo&#44; 63&#37; foram transportados aos hospitais por meios pr&#243;prios&#44; enquanto os restantes 37&#37; foram transportados de ambul&#226;ncia &#40;em pelo menos 15&#37; dos casos com avalia&#231;&#227;o m&#233;dica pr&#233;-hospitalar&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figura 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Considerando os resultados da ICP&#44; o fluxo TIMI 3 foi obtido em 83&#37; dos doentes&#44; <span class="elsevierStyleItalic">TIMI frame count</span> &#8804; 24 em 59&#37; e a resolu&#231;&#227;o do segmento ST &#8805; 70 em 45&#37; dos doentes&#46; A obten&#231;&#227;o destes marcadores indiretos de sucesso da ICP esteve associada a um menor tempo total de isqu&#233;mia&#58; em doentes com fluxo TIMI 3 a mediana do tempo total de isqu&#233;mia foi 4<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>17<span class="elsevierStyleHsp" style=""></span>m &#40;<span class="elsevierStyleItalic">versus</span> 7<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>03<span class="elsevierStyleHsp" style=""></span>min com fluxo TIMI 2&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41;&#59; com <span class="elsevierStyleItalic">TIMI frame count</span> &#8804;24 a mediana do tempo total de isqu&#233;mia foi 4<span class="elsevierStyleHsp" style=""></span>h 11<span class="elsevierStyleHsp" style=""></span>min &#40;<span class="elsevierStyleItalic">versus</span> 5<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>00<span class="elsevierStyleHsp" style=""></span>min com <span class="elsevierStyleItalic">TIMI frame count</span> &#62; 24&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#41;&#59; e com resolu&#231;&#227;o de ST &#8805; 70&#37; a mediana do tempo total de isqu&#233;mia foi 3<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>59<span class="elsevierStyleHsp" style=""></span>m &#40;<span class="elsevierStyleItalic">versus</span> 5<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>12<span class="elsevierStyleHsp" style=""></span>min com resolu&#231;&#227;o de ST &#60;<span class="elsevierStyleHsp" style=""></span>70&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Tabela 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discuss&#227;o</span><p id="par0090" class="elsevierStylePara elsevierViewall">A associa&#231;&#227;o entre a dura&#231;&#227;o da isqu&#233;mia mioc&#225;rdica e o progn&#243;stico no contexto EAMEST do ECG est&#225; claramente estabelecido e &#233; atualmente uma prioridade a obten&#231;&#227;o da perfus&#227;o mioc&#225;rdica no mais curto intervalo de tempo poss&#237;vel&#46; De facto&#44; nos &#250;ltimos anos&#44; o enfoque do tratamento do EAMEST tem sido na reorganiza&#231;&#227;o dos servi&#231;os de sa&#250;de de forma a promover o seu tratamento no mais curto intervalo de tempo poss&#237;vel&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Num estudo de Le May<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> foram analisados tempos intercalares e os intervalos definidos de forma id&#234;ntica aos nossos foram&#58; ECG-centro ICP &#40;mediana observada de 38<span class="elsevierStyleHsp" style=""></span>min&#41;&#44; centro ICP-dispositivo &#40;mediana observada de 57<span class="elsevierStyleHsp" style=""></span>min&#41;&#44; ECG-dispositivo &#40;mediana observada de 104<span class="elsevierStyleHsp" style=""></span>min&#41; e tempo total de isqu&#233;mia &#40;mediana observada de 201<span class="elsevierStyleHsp" style=""></span>min&#41;&#46; Os tempos observados neste estudo foram menores do que os que encontr&#225;mos&#44; exceto para o centro ICP-dispositivo&#44; provavelmente consequ&#234;ncia de um maior atraso na chegada dos doentes ao nosso centro&#44; dando-nos mais tempo para preparar a log&#237;stica e equipa para a ICP&#46; Este estudo tamb&#233;m comparou as diferen&#231;as de tempo em doentes referenciados diretamente do ambiente pr&#233;-hospitalar e de outros hospitais&#46; Tal como n&#243;s&#44; os tempos observados em cada intervalo foram significativamente menores quando os doentes foram referenciados diretamente do ambiente pr&#233;-hospitalar para a ICP prim&#225;ria&#46; Neste subgrupo e em ambos os estudos&#44; as medianas de tempos intercalares foram semelhantes&#44; no entanto este autor reportou uma propor&#231;&#227;o significativamente maior de doentes referenciados do pr&#233;-hospitalar &#40;39 <span class="elsevierStyleItalic">versus</span> 9&#37; no nosso estudo&#41;&#46; Esta diferen&#231;a pode ter influenciado o maior atraso observado na nossa popula&#231;&#227;o&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Noutro estudo&#44; que analisou doentes com EAMEST referenciados para ICP prim&#225;ria por equipas pr&#233;-hospitalares observou que em 66&#44;7&#37; dos casos o tempo desde o primeiro contacto m&#233;dico &#224; realiza&#231;&#227;o de ICP foi &#60; 90<span class="elsevierStyleHsp" style=""></span>min<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>&#46; Este valor &#233; semelhante ao tempo m&#233;dico-dispositivo que encontr&#225;mos no grupo pr&#233;-hospitalar&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Outro estudo multic&#234;ntrico&#44; combinando informa&#231;&#227;o de 30 pa&#237;ses diferentes<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> registou um intervalo de tempo desde o in&#237;cio dos sintomas ao primeiro contacto m&#233;dico &#40;definido como a realiza&#231;&#227;o do ECG diagn&#243;stico&#41; compreendido entre 60 e 210<span class="elsevierStyleHsp" style=""></span>min e desde o primeiro contacto m&#233;dico &#224; ICP entre 60 e 177<span class="elsevierStyleHsp" style=""></span>min&#46; Os intervalos que observ&#225;mos encontram-se aproximadamente no centro dos apresentados neste estudo&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Um trabalho nacional por Trigo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> reportou uma mediana da demora pr&#233;-hospitalar que variou entre 3<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>31<span class="elsevierStyleHsp" style=""></span>min e 4<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>05<span class="elsevierStyleHsp" style=""></span>min&#44; tempos ligeiramente acima dos que observ&#225;mos&#46; Por outro lado&#44; a mediana da demora intra-hospitalar variou entre 1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>26<span class="elsevierStyleHsp" style=""></span>min e 2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>min&#44; tempos ligeiramente abaixo dos que apresent&#225;mos&#46; Estas diferen&#231;as podem estar relacionadas com diferen&#231;as na organiza&#231;&#227;o dos 2 centros&#58; a nossa &#225;rea de referencia&#231;&#227;o &#233; menor &#40;logo com tempos pr&#233;-hospitalares menores&#41; mas n&#227;o tem departamento de urg&#234;ncia no local&#44; sendo maiorit&#225;ria a refer&#234;ncia de outros hospitais &#40;logo com maiores tempos intra-hospitalares&#41;&#46; Outro estudo&#44; por Ribeiro et al&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> analisou somente a demora pr&#233;-hospitalar neste contexto&#44; obtendo uma mediana de 2&#44;16<span class="elsevierStyleHsp" style=""></span>h&#44; semelhante ao que encontr&#225;mos&#46; Finalmente&#44; um estudo de Ramos et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> observou uma mediana de tempo total de isqu&#233;mia de 7&#44;64<span class="elsevierStyleHsp" style=""></span>h &#40;12&#44;1<span class="elsevierStyleHsp" style=""></span>h se o doente se apresentasse em choque cardiog&#233;nico&#41;&#44; tempos ligeiramente acima dos nossos&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Observ&#225;mos demoras menores em doentes referenciados para ICP pelo sistema de emerg&#234;ncia m&#233;dica&#46; Contudo&#44; no restante grupo&#44; houve uma propor&#231;&#227;o importante de doentes que tinham sido avaliados por profissionais de sa&#250;de antes de serem transportados para um hospital sem capacidade de ICP&#46; Estes doentes foram transportados sem a realiza&#231;&#227;o pr&#233;-hospitalar de ECG ou se este foi realizado n&#227;o se chegou ao diagn&#243;stico de EAMEST&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">A an&#225;lise dos marcadores indiretos de perfus&#227;o mioc&#225;rdica com sucesso&#44; ap&#243;s ICP&#44; revelou uma associa&#231;&#227;o entre a presen&#231;a de um melhor fluxo TIMI final&#44; de um menor TIMI <span class="elsevierStyleItalic">frame count</span> final e de uma maior resolu&#231;&#227;o do segmento ST com um tempo total de isqu&#233;mia menor&#46; Estes dados sugerem que um tempo de isqu&#233;mia menor se associa a uma maior probabilidade de sucesso da ICP&#46; Dados semelhantes foram observados noutros trabalhos onde se verificou uma associa&#231;&#227;o entre menor tempo de isqu&#233;mia e um melhor resultado de ICP prim&#225;ria avaliada pelo <span class="elsevierStyleItalic">TIMI frame count</span> corrigido<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&#46; N&#227;o encontramos refer&#234;ncias relativamente &#224; associa&#231;&#227;o entre um tempo de isqu&#233;mia menor e um fluxo TIMI p&#243;s-ICP melhor ou uma maior resolu&#231;&#227;o do segmento ST no contexto de ICP prim&#225;ria por EAMEST&#46; No entanto&#44; estes dados est&#227;o bastante estudados como marcadores de sucesso da ICP<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;18</span></a>&#46; A associa&#231;&#227;o que encontramos entre um melhor resultado da ICP por este meio e um menor tempo de isqu&#233;mia refor&#231;am a import&#226;ncia da precocidade da reperfus&#227;o no EAMEST&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclus&#227;o</span><p id="par0125" class="elsevierStylePara elsevierViewall">Este estudo evidencia que&#44; apesar da disponibilidade de um sistema de emerg&#234;ncia m&#233;dica pr&#233;-hospitalar dispon&#237;vel 24<span class="elsevierStyleHsp" style=""></span>h&#44; e que os doentes com enfarte agudo que a ele recorrem apresentarem tempos de isqu&#233;mia totais significativamente menores&#44; apenas uma pequena percentagem de doentes o faz&#44; confirmando que a atitude dos doentes com EAMEST tem um papel decisivo nos resultados obtidos e no consequente cumprimento das recomenda&#231;&#245;es&#46; De facto&#44; os intervalos com maior atraso foram o intervalo dor-m&#233;dico e m&#233;dico-dispositivo sendo este &#250;ltimo imputado &#224; organiza&#231;&#227;o interna dos hospitais&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Nesta popula&#231;&#227;o apenas uma minoria de doentes com enfarte do mioc&#225;rdio com supradesnivelamento ST foram revascularizados dentro da janela temporal recomendada&#46; A responsabilidade nos atrasos observados parece ser multifatorial&#44; relacionada n&#227;o s&#243; com uma atitude inadequada dos doentes aquando do seu primeiro pedido de ajuda&#44; como podendo ser atribu&#237;da a aspetos organizacionais dos diferentes sistemas de sa&#250;de envolvidos&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflito de interesses</span><p id="par0135" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflito de interesses&#46;</p></span></span>"
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    "fechaRecibido" => "2011-06-15"
    "fechaAceptado" => "2012-04-23"
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            0 => "Angioplastia prim&#225;ria"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introdu&#231;&#227;o</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Segundo as recomenda&#231;&#245;es atuais para o tratamento do enfarte agudo do mioc&#225;rdio com supra-desnivelamento do segmento ST a interven&#231;&#227;o coron&#225;ria percut&#226;nea deve ser efetuada dentro de 90<span class="elsevierStyleHsp" style=""></span>min ap&#243;s o primeiro contacto m&#233;dico e o tempo total de isqu&#233;mia n&#227;o deve exceder os 120<span class="elsevierStyleHsp" style=""></span>min&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">O objetivo deste trabalho foi analisar a adequa&#231;&#227;o da implementa&#231;&#227;o destas recomenda&#231;&#245;es para o enfarte do mioc&#225;rdio com supra-desnivelamento do segmento ST num centro terci&#225;rio de interven&#231;&#227;o coron&#225;ria percut&#226;nea&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Registo prospetivo de centro &#250;nico de 223 doentes consecutivos referenciados para interven&#231;&#227;o coron&#225;ria percut&#226;nea prim&#225;ria entre 2003 e 2007&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nesta popula&#231;&#227;o &#40;idade m&#233;dia 60<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 anos&#44; 76&#37; de sexo masculino&#41;&#44; a mediana do tempo total de isqu&#233;mia foi 4<span class="elsevierStyleHsp" style=""></span>h 30<span class="elsevierStyleHsp" style=""></span>min &#40;&#60; 120<span class="elsevierStyleHsp" style=""></span>min em 4&#37; dos doentes&#41;&#46; O intervalo de tempo com menor atraso foi desde o primeiro contacto m&#233;dico at&#233; &#224; realiza&#231;&#227;o do ECG &#40;mediana 8<span class="elsevierStyleHsp" style=""></span>min&#44; &#60;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>min em 59&#37; dos doentes&#41;&#46; Os intervalos com maior atraso foram&#58; do in&#237;cio dos sintomas ao primeiro contacto m&#233;dico &#40;mediana 104<span class="elsevierStyleHsp" style=""></span>min&#44; &#60;<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min em 6&#37; dos doentes&#41; e do primeiro ECG &#224; realiza&#231;&#227;o da interven&#231;&#227;o coron&#225;ria &#40;mediana 140<span class="elsevierStyleHsp" style=""></span>min&#44; &#60;<span class="elsevierStyleHsp" style=""></span>90<span class="elsevierStyleHsp" style=""></span>min em 16&#37; dos doentes&#41;&#46; O menor tempo total de isqu&#233;mia associou-se a melhor fluxo TIMI final&#44; melhor TIMI <span class="elsevierStyleItalic">frame count</span> final e maior resolu&#231;&#227;o do segmento ST ap&#243;s angioplastia &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#41;&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">As tr&#234;s origens mais frequentes dos doentes foram&#58; dois hospitais de localidades pr&#243;ximas e o sistema de emerg&#234;ncia m&#233;dica pr&#233;-hospitalar&#46; No grupo pr&#233;-hospitalar verificou-se menor tempo total de isqu&#233;mia do que nos hospitais A ou B &#40;2<span class="elsevierStyleHsp" style=""></span>h 45<span class="elsevierStyleHsp" style=""></span>min <span class="elsevierStyleItalic">versus</span> 4<span class="elsevierStyleHsp" style=""></span>h 44<span class="elsevierStyleHsp" style=""></span>min e 6<span class="elsevierStyleHsp" style=""></span>h 40<span class="elsevierStyleHsp" style=""></span>min&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#44; com menor tempo desde o primeiro contacto m&#233;dico at&#233; &#224; angioplastia &#40;89<span class="elsevierStyleHsp" style=""></span>min <span class="elsevierStyleItalic">versus</span> 147 e 146<span class="elsevierStyleHsp" style=""></span>min&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclus&#227;o</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Nesta popula&#231;&#227;o&#44; apenas uma reduzida percentagem de doentes com enfarte agudo do mioc&#225;rdio obteve tratamento adequado por angioplastia prim&#225;ria dentro dos tempos recomendados&#46; Os doentes referenciados pelo sistema de emerg&#234;ncia pr&#233;-hospitalar&#44; embora em reduzida percentagem do total&#44; foram os que obtiveram os melhores resultados na precocidade do tratamento&#46; O cumprimento das recomenda&#231;&#245;es traduz-se em melhores resultados na perfus&#227;o mioc&#225;rdica obtida pela angioplastia prim&#225;ria&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">According to the current guidelines for treatment of ST-elevation myocardial infarction &#40;STEMI&#41;&#44; percutaneous coronary intervention &#40;PCI&#41; should be performed within 90<span class="elsevierStyleHsp" style=""></span>min of first medical contact and total ischemic time should not exceed 120<span class="elsevierStyleHsp" style=""></span>min&#46; The aim of this study was to analyze compliance with STEMI guidelines in a tertiary PCI center&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">This was a prospective single-center registry of 223 consecutive STEMI patients referred for primary PCI between 2003 and 2007&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">In this population &#40;mean age 60<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 years&#44; 76&#37; male&#41;&#44; median total ischemic time was 4<span class="elsevierStyleHsp" style=""></span>h 30<span class="elsevierStyleHsp" style=""></span>min &#40;&#60;120<span class="elsevierStyleHsp" style=""></span>min in 4&#37; of patients&#41;&#46; The interval with the best performance was first medical contact to first ECG &#40;median 8<span class="elsevierStyleHsp" style=""></span>min&#44; &#60;10<span class="elsevierStyleHsp" style=""></span>min in 59&#37; of patients&#41;&#46; The worst intervals were symptom onset to first medical contact &#40;median 104<span class="elsevierStyleHsp" style=""></span>min&#44; &#60;30<span class="elsevierStyleHsp" style=""></span>min in 6&#37;&#41; and first ECG to PCI &#40;median 140<span class="elsevierStyleHsp" style=""></span>min&#44; &#60;90<span class="elsevierStyleHsp" style=""></span>min in 16&#37;&#41;&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Shorter total ischemic time was associated with better post-PCI TIMI flow&#44; TIMI frame count and ST-segment resolution &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#41;&#46; The three most common patient origins were two nearby hospitals &#40;A and B&#41; and the pre-hospital emergency system&#46; The pre-hospital group had shorter total ischemic time than patients from hospitals A or B &#40;2<span class="elsevierStyleHsp" style=""></span>h 45<span class="elsevierStyleHsp" style=""></span>min vs&#46; 4<span class="elsevierStyleHsp" style=""></span>h 44<span class="elsevierStyleHsp" style=""></span>min and 6<span class="elsevierStyleHsp" style=""></span>h 40<span class="elsevierStyleHsp" style=""></span>min&#44; respectively&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#44; with shorter door-to-balloon time &#40;89<span class="elsevierStyleHsp" style=""></span>min vs&#46; 147<span class="elsevierStyleHsp" style=""></span>min and 146<span class="elsevierStyleHsp" style=""></span>min&#44; respectively&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">In this population&#44; only a small proportion of patients with acute myocardial infarction underwent primary PCI within the recommended time&#46; Patients referred through the pre-hospital emergency system&#44; although a minority&#44; had the best results in terms of early treatment&#46; Compliance with the guidelines translates into better myocardial perfusion achieved through primary PCI&#46;</p>"
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                  \t\t\t\t">6&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#233;dico-ECG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>08<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ECG-centro ICP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>34<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Centro ICP-dispositivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ECG-Dispositivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>20<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>03<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#233;dico-dispositivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>20<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tempo total de isqu&#233;mia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab354917.png"
              ]
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        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Mediana dos tempos observados comparados com o m&#225;ximo recomendado na popula&#231;&#227;o total</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">&#60; Max &#40;&#37;&#41;&#58; percentagem de doentes em que o tempo observado foi inferior ao m&#225;ximo recomendado&#59; Centro ICP-dispositivo&#58; desde a chegada ao centro com capacidade para ICP at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o&#59; Dor-m&#233;dico&#58; desde o in&#237;cio dos sintomas at&#233; ao primeiro contacto m&#233;dico&#59; ECG-centro ICP&#58; desde a realiza&#231;&#227;o do ECG diagn&#243;stico at&#233; &#224; chegada ao centro com capacidade de ICP&#59; ECG-dispositivo&#58; desde a realiza&#231;&#227;o do ECG diagn&#243;stico at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o&#59; M&#233;dico-dispositivo&#58; desde o primeiro contacto m&#233;dico at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o&#59; M&#233;dico-ECG&#58; desde o primeiro contacto m&#233;dico at&#233; &#224; realiza&#231;&#227;o do ECG diagn&#243;stico&#59; Obs&#46;&#58; Observado&#59; Tempo total de isquemia&#58; desde o in&#237;cio dos sintomas at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o&#59; TR Max&#58; tempo m&#225;ximo recomendado&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TR Max&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Pre-Hosp</td><td class="td" title="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Hosp-A</td><td class="td" title="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Hosp-B</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Obs&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#60; TR Max &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Obs&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#60; TR Max &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Obs&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#60; TR Max &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dor-m&#233;dico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>47<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>32<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#233;dico-ECG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>07<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">71&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>13<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>06<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ECG-centro ICP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>36<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>46<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>39<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Centro ICP-dispositivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>44<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>27<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>24<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ECG-Dispositivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>20min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>22min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>20<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>22<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#233;dico-dispositivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>29min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>27<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>26<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">4&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tempo total de isqu&#233;mia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>00<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>45<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">6&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>44<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab354915.png"
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        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Mediana dos tempos observados comparados com o m&#225;ximo recomendado de acordo com a proveni&#234;ncia dos doentes</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabela 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">TIMI&#58; fluxo TIMI p&#243;s ICP&#59; <span class="elsevierStyleItalic">TIMI Frame Count</span>&#58; <span class="elsevierStyleItalic">TIMI Frame Count</span> corrigido p&#243;s-ICP&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Tempo total de isqu&#233;mia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">TIMI 2 <span class="elsevierStyleItalic">versus</span> 3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>03<span class="elsevierStyleHsp" style=""></span>m <span class="elsevierStyleItalic">versus</span> 4<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>17<span class="elsevierStyleHsp" style=""></span>m&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TIMI <span class="elsevierStyleItalic">Frame count</span> &#62;<span class="elsevierStyleHsp" style=""></span>24 <span class="elsevierStyleItalic">versus</span> &#8804; 24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>00<span class="elsevierStyleHsp" style=""></span>m <span class="elsevierStyleItalic">versus</span> 4<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>11<span class="elsevierStyleHsp" style=""></span>m&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resolu&#231;&#227;o de ST &#60;<span class="elsevierStyleHsp" style=""></span>70 <span class="elsevierStyleItalic">versus</span> &#8805;<span class="elsevierStyleHsp" style=""></span>70&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>12<span class="elsevierStyleHsp" style=""></span>m <span class="elsevierStyleItalic">versus</span> 3<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>59<span class="elsevierStyleHsp" style=""></span>m&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab354916.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Mediana do tempo total de isqu&#233;mia observado de acordo com marcadores indiretos de sucesso da ICP</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliografia"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:18 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction&#58; a quantitative review of 23 randomised trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46;C&#46; Keeley"
                            1 => "J&#46;A&#46; Boura"
                            2 => "C&#46;L&#46; Grines"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(03)12113-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2003"
                        "volumen" => "361"
                        "paginaInicial" => "13"
                        "paginaFinal" => "20"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12517460"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of door-to-balloon time and mortality in patients admitted to hospital with ST elevation myocardial infarction&#58; national cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;S&#46; Rathore"
                            1 => "J&#46;P&#46; Curtis"
                            2 => "J&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2009"
                        "volumen" => "338"
                        "paginaInicial" => "b1807"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19454739"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
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Artigo Original
ICP primária no enfarte de miocárdio com supradesnivelamento do segmento ST: tempo para intervenção e modos de referenciação
Primary PCI in ST-elevation myocardial infarction: Mode of referral and time to PCI
Pedro Jerónimo Sousa
Autor para correspondência
p965675551@gmail.com

Autor para correspondência.
, Rui Campante Teles, João Brito, João Abecasis, Pedro de Araújo Gonçalves, Rita Calé, Sílvio Leal, Raquel Dourado, Luís Raposo, Aniceto Silva, Manuel Almeida, Miguel Mendes
Serviço de Cardiologia, Hospital de Santa Cruz, Carnaxide, Portugal
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as recomenda&#231;&#245;es do <span class="elsevierStyleItalic">American College of Cardiology</span> preconizam que os doentes com EAMEST que recorram aos hospitais com capacidade de realizar ICP prim&#225;ria devam ser tratados em 90<span class="elsevierStyleHsp" style=""></span>min ap&#243;s o primeiro contacto m&#233;dico &#40;recomenda&#231;&#227;o classe <span class="elsevierStyleSmallCaps">i</span>&#44; n&#237;vel de evid&#234;ncia A&#41;&#44; n&#227;o devendo o tempo total de isqu&#233;mia ultrapassar os 120<span class="elsevierStyleHsp" style=""></span>min<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Adicionalmente&#44; dada a import&#226;ncia do ECG de 12 deriva&#231;&#245;es neste contexto&#44; este deve ser obtido em menos de 10<span class="elsevierStyleHsp" style=""></span>min&#44; desde o primeiro contacto m&#233;dico&#44; em doentes que apresentem desconforto tor&#225;cico<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#46; Recomenda&#231;&#245;es semelhantes foram adotadas por sociedades nacionais&#46; Em Portugal &#233; indicado que o atraso na transfer&#234;ncia de doentes para um centro com capacidade de realizar ICP prim&#225;ria n&#227;o deve exceder os 30<span class="elsevierStyleHsp" style=""></span>min<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">O objetivo deste trabalho foi analisar a adequa&#231;&#227;o do tratamento dos doentes com EAMEST submetidos a ICP prim&#225;ria num centro terci&#225;rio&#44; examinando os tempos decorridos nas diferentes fases da abordagem dos doentes com enfarte at&#233; &#224; ICP prim&#225;ria&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="par0030" class="elsevierStylePara elsevierViewall">Com base no registo prospetivo &#40;<span class="elsevierStyleItalic">Angioplasty and Coronary Revascularization On Santa Cruz Hospital</span>&#41; &#40;ACROSS&#41; que inclui todos os doentes consecutivos submetidos a ICP num &#250;nico centro de interven&#231;&#227;o terci&#225;rio desde 2002&#44; selecionamos no per&#237;odo compreendido entre 2003 e 2007&#44; 223 doentes consecutivos com EAMEST submetidos a ICP prim&#225;ria&#46; O diagn&#243;stico de EAMEST foi estabelecido em doentes com dor tor&#225;cica aguda com dura&#231;&#227;o superior a 30<span class="elsevierStyleHsp" style=""></span>min e eleva&#231;&#227;o do segmento ST em pelo menos 2 deriva&#231;&#245;es cont&#237;guas no ECG de 12 deriva&#231;&#245;es ou com bloqueio completo de ramo esquerdo de novo&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Os tempos totais e intercalares desde o in&#237;cio dos sintomas at&#233; &#224; realiza&#231;&#227;o da ICP prim&#225;ria foram analisados e comparados com as recomenda&#231;&#245;es&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Os intervalos de tempo foram definidos prospetivamente e comparados com os recomendados do seguinte modo&#58; <span class="elsevierStyleItalic">dor-m&#233;dico</span> - desde o in&#237;cio dos sintomas at&#233; ao primeiro contacto m&#233;dico &#40;tempo recomendado &#40;TR&#41; - desde o primeiro contacto m&#233;dico at&#233; &#224; realiza&#231;&#227;o do ECG diagn&#243;stico &#40;TR &#60; 10<span class="elsevierStyleHsp" style=""></span>min&#41;&#59; <span class="elsevierStyleItalic">ECG-centro ICP</span>&#44; desde a realiza&#231;&#227;o do ECG diagn&#243;stico at&#233; &#224; chegada ao centro com capacidade de ICP &#40;TR &#60; 30<span class="elsevierStyleHsp" style=""></span>min&#41;&#59; <span class="elsevierStyleItalic">centro ICP-dispositivo</span>&#44; desde a chegada ao centro com capacidade para ICP at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o &#40;TR &#60; 50<span class="elsevierStyleHsp" style=""></span>min&#41;&#59; <span class="elsevierStyleItalic">ECG-dispositivo</span>&#44; desde a realiza&#231;&#227;o do ECG diagn&#243;stico at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o &#40;TR &#60; 80<span class="elsevierStyleHsp" style=""></span>min&#41;&#59; <span class="elsevierStyleItalic">m&#233;dico-dispositivo</span>&#44; desde o primeiro contacto m&#233;dico at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o &#40;TR &#60; 90<span class="elsevierStyleHsp" style=""></span>min&#41;&#59; e <span class="elsevierStyleItalic">tempo total de isqu&#233;mia</span>&#44; desde o in&#237;cio dos sintomas at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o &#40;TR &#60; 120<span class="elsevierStyleHsp" style=""></span>min&#41;&#46; Estes limites de tempo foram definidos segundo recomenda&#231;&#245;es nacionais e internacionais<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;7</span></a>&#46; A popula&#231;&#227;o foi dividida em 3 grupos&#44; de acordo com a sua origem&#58; Hospital A &#40;a 6<span class="elsevierStyleHsp" style=""></span>km de dist&#226;ncia do nosso centro&#41;&#44; Hospital B &#40;a 22<span class="elsevierStyleHsp" style=""></span>km de dist&#226;ncia do nosso centro&#41; e sistema de emerg&#234;ncia pr&#233;-hospitalar&#46; Os intervalos de tempo avaliados foram comparados entre estes grupos&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Foram avaliados ainda os seguintes par&#226;metros relacionados com a perfus&#227;o mioc&#225;rdica&#58; o fluxo TIMI&#44; o <span class="elsevierStyleItalic">TIMI frame count</span> e a resolu&#231;&#227;o do segmento ST ap&#243;s a ICP&#46; O fluxo TIMI e o <span class="elsevierStyleItalic">TIMI frame count</span> foram calculados de acordo com refer&#234;ncias publicadas<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a>&#46; A resolu&#231;&#227;o do segmento ST foi calculada com a soma de todas as deriva&#231;&#245;es que apresentavam eleva&#231;&#227;o ST no ECG diagn&#243;stico&#46; Estas vari&#225;veis foram usadas como marcadores indiretos do sucesso da ICP do seguinte modo&#58; fluxo TIMI 3&#44; <span class="elsevierStyleItalic">TIMI frame count</span> &#8804; 24 e resolu&#231;&#227;o do segmento ST &#8805;70&#37;&#46; Foram comparadas diferen&#231;as no tempo total de isqu&#233;mia na presen&#231;a e aus&#234;ncia destes marcadores indiretos de sucesso da ICP&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lise estat&#237;stica</span><p id="par0050" class="elsevierStylePara elsevierViewall">As vari&#225;veis categ&#243;ricas apresentam-se como n&#250;mero &#47; percentagem&#46; As vari&#225;veis cont&#237;nuas s&#227;o apresentadas como m&#233;dia &#177; desvio padr&#227;o&#44; exceto para os valores temporais&#44; que se apresentam como mediana&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Diferen&#231;as entre vari&#225;veis cont&#237;nuas foram testadas usando o teste de Mann-Whitney ou de Kruskal-Wallis&#46; As diferen&#231;as observadas foram consideradas significativas quando p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 &#40;intervalo de confian&#231;a 0&#44;95&#41;&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Resultados</span><p id="par0060" class="elsevierStylePara elsevierViewall">Na popula&#231;&#227;o selecionada de 223 doentes&#44; a idade m&#233;dia foi 60<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 anos&#44; com 76&#37; de doentes do sexo masculino&#46; Os fatores de risco cardiovasculares presentes eram&#58; diabetes em 17&#37; dos doentes&#44; tabagismo &#40;ativo ou antigo&#41; em 56&#37;&#44; hipertens&#227;o em 55&#37; e dislipid&#233;mia em 50&#37;&#46; Na apresenta&#231;&#227;o 7&#37; tinham uma classe de Killip-Kimball &#8805;<span class="elsevierStyleHsp" style=""></span>3 e 18&#37; dos doentes tinham antecedentes de enfarte do mioc&#225;rdio&#44; 19&#37; de ICP&#44; 4&#37; de cirurgia de revasculariza&#231;&#227;o mioc&#225;rdica&#44; 5&#37; de doen&#231;a cerebrovascular e 2&#37; apresentavam insufici&#234;ncia renal com necessidade de di&#225;lise&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Os intervalos de tempo totais e intercalares apresentam-se na <a class="elsevierStyleCrossRef" href="#tbl0005">Tabela 1</a> e <a class="elsevierStyleCrossRef" href="#fig0005">Figura 1</a>&#46; A mediana do tempo total de isqu&#233;mia foi 4<span class="elsevierStyleHsp" style=""></span>h 30<span class="elsevierStyleHsp" style=""></span>min&#44; sendo que apenas 4&#37; realizaram a ICP em menos de 120<span class="elsevierStyleHsp" style=""></span>min&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Os intervalos com menor atraso foram o intervalo m&#233;dico-ECG&#44; com uma mediana de 8<span class="elsevierStyleHsp" style=""></span>min &#40;&#60;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>min em 59&#37; dos doentes&#41; e centro ICP-dispositivo&#44; com uma mediana de 30<span class="elsevierStyleHsp" style=""></span>min &#40;&#60;<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>min em 75&#37; dos doentes&#41;&#46; Os intervalos com maior atraso foram o intervalo dor-m&#233;dico&#44; com uma mediana de 104<span class="elsevierStyleHsp" style=""></span>min &#40;&#60; 30<span class="elsevierStyleHsp" style=""></span>min em 6&#37; dos doentes&#41; e m&#233;dico-dispositivo com mediana de 140 min &#40;&#60;<span class="elsevierStyleHsp" style=""></span>90<span class="elsevierStyleHsp" style=""></span>min em 16&#37; dos doentes&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">A origem mais frequente foi o Hospital A &#40;64&#37;&#41;&#44; seguida do Hospital B &#40;15&#37;&#41; e sistema de emerg&#234;ncia pr&#233;-hospitalar &#40;9&#37;&#41;&#46; Os restantes 12&#37; provieram de outras institui&#231;&#245;es de sa&#250;de ou recorreram diretamente ao nosso centro pelos seus pr&#243;prios meios&#46; Os tempos totais e intercalares de cada grupo apresentam-se na <a class="elsevierStyleCrossRef" href="#tbl0010">Tabela 2</a> e <a class="elsevierStyleCrossRef" href="#fig0010">Figura 2</a>&#46; O grupo pr&#233;-hospitalar obteve menor tempo total de isqu&#233;mia que o Hospital A ou B &#40;2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>45<span class="elsevierStyleHsp" style=""></span>min <span class="elsevierStyleItalic">versus</span> 4<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>44<span class="elsevierStyleHsp" style=""></span>h e 6<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>min&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Esta diferen&#231;a resultou principalmente de um tempo dor-m&#233;dico menor &#40;75 <span class="elsevierStyleItalic">versus</span> 107 e 152<span class="elsevierStyleHsp" style=""></span>min&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; e ECG-centro ICP tamb&#233;m menor &#40;36 <span class="elsevierStyleItalic">versus</span> 106 e 99<span class="elsevierStyleHsp" style=""></span>min&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Do total da amostra&#44; 203 doentes n&#227;o foram referenciados diretamente pelo sistema de emerg&#234;ncia pr&#233;-hospitalar para o nosso centro&#46; Neste grupo&#44; 63&#37; foram transportados aos hospitais por meios pr&#243;prios&#44; enquanto os restantes 37&#37; foram transportados de ambul&#226;ncia &#40;em pelo menos 15&#37; dos casos com avalia&#231;&#227;o m&#233;dica pr&#233;-hospitalar&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figura 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Considerando os resultados da ICP&#44; o fluxo TIMI 3 foi obtido em 83&#37; dos doentes&#44; <span class="elsevierStyleItalic">TIMI frame count</span> &#8804; 24 em 59&#37; e a resolu&#231;&#227;o do segmento ST &#8805; 70 em 45&#37; dos doentes&#46; A obten&#231;&#227;o destes marcadores indiretos de sucesso da ICP esteve associada a um menor tempo total de isqu&#233;mia&#58; em doentes com fluxo TIMI 3 a mediana do tempo total de isqu&#233;mia foi 4<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>17<span class="elsevierStyleHsp" style=""></span>m &#40;<span class="elsevierStyleItalic">versus</span> 7<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>03<span class="elsevierStyleHsp" style=""></span>min com fluxo TIMI 2&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41;&#59; com <span class="elsevierStyleItalic">TIMI frame count</span> &#8804;24 a mediana do tempo total de isqu&#233;mia foi 4<span class="elsevierStyleHsp" style=""></span>h 11<span class="elsevierStyleHsp" style=""></span>min &#40;<span class="elsevierStyleItalic">versus</span> 5<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>00<span class="elsevierStyleHsp" style=""></span>min com <span class="elsevierStyleItalic">TIMI frame count</span> &#62; 24&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#41;&#59; e com resolu&#231;&#227;o de ST &#8805; 70&#37; a mediana do tempo total de isqu&#233;mia foi 3<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>59<span class="elsevierStyleHsp" style=""></span>m &#40;<span class="elsevierStyleItalic">versus</span> 5<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>12<span class="elsevierStyleHsp" style=""></span>min com resolu&#231;&#227;o de ST &#60;<span class="elsevierStyleHsp" style=""></span>70&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Tabela 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discuss&#227;o</span><p id="par0090" class="elsevierStylePara elsevierViewall">A associa&#231;&#227;o entre a dura&#231;&#227;o da isqu&#233;mia mioc&#225;rdica e o progn&#243;stico no contexto EAMEST do ECG est&#225; claramente estabelecido e &#233; atualmente uma prioridade a obten&#231;&#227;o da perfus&#227;o mioc&#225;rdica no mais curto intervalo de tempo poss&#237;vel&#46; De facto&#44; nos &#250;ltimos anos&#44; o enfoque do tratamento do EAMEST tem sido na reorganiza&#231;&#227;o dos servi&#231;os de sa&#250;de de forma a promover o seu tratamento no mais curto intervalo de tempo poss&#237;vel&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Num estudo de Le May<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> foram analisados tempos intercalares e os intervalos definidos de forma id&#234;ntica aos nossos foram&#58; ECG-centro ICP &#40;mediana observada de 38<span class="elsevierStyleHsp" style=""></span>min&#41;&#44; centro ICP-dispositivo &#40;mediana observada de 57<span class="elsevierStyleHsp" style=""></span>min&#41;&#44; ECG-dispositivo &#40;mediana observada de 104<span class="elsevierStyleHsp" style=""></span>min&#41; e tempo total de isqu&#233;mia &#40;mediana observada de 201<span class="elsevierStyleHsp" style=""></span>min&#41;&#46; Os tempos observados neste estudo foram menores do que os que encontr&#225;mos&#44; exceto para o centro ICP-dispositivo&#44; provavelmente consequ&#234;ncia de um maior atraso na chegada dos doentes ao nosso centro&#44; dando-nos mais tempo para preparar a log&#237;stica e equipa para a ICP&#46; Este estudo tamb&#233;m comparou as diferen&#231;as de tempo em doentes referenciados diretamente do ambiente pr&#233;-hospitalar e de outros hospitais&#46; Tal como n&#243;s&#44; os tempos observados em cada intervalo foram significativamente menores quando os doentes foram referenciados diretamente do ambiente pr&#233;-hospitalar para a ICP prim&#225;ria&#46; Neste subgrupo e em ambos os estudos&#44; as medianas de tempos intercalares foram semelhantes&#44; no entanto este autor reportou uma propor&#231;&#227;o significativamente maior de doentes referenciados do pr&#233;-hospitalar &#40;39 <span class="elsevierStyleItalic">versus</span> 9&#37; no nosso estudo&#41;&#46; Esta diferen&#231;a pode ter influenciado o maior atraso observado na nossa popula&#231;&#227;o&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Noutro estudo&#44; que analisou doentes com EAMEST referenciados para ICP prim&#225;ria por equipas pr&#233;-hospitalares observou que em 66&#44;7&#37; dos casos o tempo desde o primeiro contacto m&#233;dico &#224; realiza&#231;&#227;o de ICP foi &#60; 90<span class="elsevierStyleHsp" style=""></span>min<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>&#46; Este valor &#233; semelhante ao tempo m&#233;dico-dispositivo que encontr&#225;mos no grupo pr&#233;-hospitalar&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Outro estudo multic&#234;ntrico&#44; combinando informa&#231;&#227;o de 30 pa&#237;ses diferentes<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> registou um intervalo de tempo desde o in&#237;cio dos sintomas ao primeiro contacto m&#233;dico &#40;definido como a realiza&#231;&#227;o do ECG diagn&#243;stico&#41; compreendido entre 60 e 210<span class="elsevierStyleHsp" style=""></span>min e desde o primeiro contacto m&#233;dico &#224; ICP entre 60 e 177<span class="elsevierStyleHsp" style=""></span>min&#46; Os intervalos que observ&#225;mos encontram-se aproximadamente no centro dos apresentados neste estudo&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Um trabalho nacional por Trigo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> reportou uma mediana da demora pr&#233;-hospitalar que variou entre 3<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>31<span class="elsevierStyleHsp" style=""></span>min e 4<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>05<span class="elsevierStyleHsp" style=""></span>min&#44; tempos ligeiramente acima dos que observ&#225;mos&#46; Por outro lado&#44; a mediana da demora intra-hospitalar variou entre 1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>26<span class="elsevierStyleHsp" style=""></span>min e 2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>min&#44; tempos ligeiramente abaixo dos que apresent&#225;mos&#46; Estas diferen&#231;as podem estar relacionadas com diferen&#231;as na organiza&#231;&#227;o dos 2 centros&#58; a nossa &#225;rea de referencia&#231;&#227;o &#233; menor &#40;logo com tempos pr&#233;-hospitalares menores&#41; mas n&#227;o tem departamento de urg&#234;ncia no local&#44; sendo maiorit&#225;ria a refer&#234;ncia de outros hospitais &#40;logo com maiores tempos intra-hospitalares&#41;&#46; Outro estudo&#44; por Ribeiro et al&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> analisou somente a demora pr&#233;-hospitalar neste contexto&#44; obtendo uma mediana de 2&#44;16<span class="elsevierStyleHsp" style=""></span>h&#44; semelhante ao que encontr&#225;mos&#46; Finalmente&#44; um estudo de Ramos et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> observou uma mediana de tempo total de isqu&#233;mia de 7&#44;64<span class="elsevierStyleHsp" style=""></span>h &#40;12&#44;1<span class="elsevierStyleHsp" style=""></span>h se o doente se apresentasse em choque cardiog&#233;nico&#41;&#44; tempos ligeiramente acima dos nossos&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Observ&#225;mos demoras menores em doentes referenciados para ICP pelo sistema de emerg&#234;ncia m&#233;dica&#46; Contudo&#44; no restante grupo&#44; houve uma propor&#231;&#227;o importante de doentes que tinham sido avaliados por profissionais de sa&#250;de antes de serem transportados para um hospital sem capacidade de ICP&#46; Estes doentes foram transportados sem a realiza&#231;&#227;o pr&#233;-hospitalar de ECG ou se este foi realizado n&#227;o se chegou ao diagn&#243;stico de EAMEST&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">A an&#225;lise dos marcadores indiretos de perfus&#227;o mioc&#225;rdica com sucesso&#44; ap&#243;s ICP&#44; revelou uma associa&#231;&#227;o entre a presen&#231;a de um melhor fluxo TIMI final&#44; de um menor TIMI <span class="elsevierStyleItalic">frame count</span> final e de uma maior resolu&#231;&#227;o do segmento ST com um tempo total de isqu&#233;mia menor&#46; Estes dados sugerem que um tempo de isqu&#233;mia menor se associa a uma maior probabilidade de sucesso da ICP&#46; Dados semelhantes foram observados noutros trabalhos onde se verificou uma associa&#231;&#227;o entre menor tempo de isqu&#233;mia e um melhor resultado de ICP prim&#225;ria avaliada pelo <span class="elsevierStyleItalic">TIMI frame count</span> corrigido<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&#46; N&#227;o encontramos refer&#234;ncias relativamente &#224; associa&#231;&#227;o entre um tempo de isqu&#233;mia menor e um fluxo TIMI p&#243;s-ICP melhor ou uma maior resolu&#231;&#227;o do segmento ST no contexto de ICP prim&#225;ria por EAMEST&#46; No entanto&#44; estes dados est&#227;o bastante estudados como marcadores de sucesso da ICP<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;18</span></a>&#46; A associa&#231;&#227;o que encontramos entre um melhor resultado da ICP por este meio e um menor tempo de isqu&#233;mia refor&#231;am a import&#226;ncia da precocidade da reperfus&#227;o no EAMEST&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclus&#227;o</span><p id="par0125" class="elsevierStylePara elsevierViewall">Este estudo evidencia que&#44; apesar da disponibilidade de um sistema de emerg&#234;ncia m&#233;dica pr&#233;-hospitalar dispon&#237;vel 24<span class="elsevierStyleHsp" style=""></span>h&#44; e que os doentes com enfarte agudo que a ele recorrem apresentarem tempos de isqu&#233;mia totais significativamente menores&#44; apenas uma pequena percentagem de doentes o faz&#44; confirmando que a atitude dos doentes com EAMEST tem um papel decisivo nos resultados obtidos e no consequente cumprimento das recomenda&#231;&#245;es&#46; De facto&#44; os intervalos com maior atraso foram o intervalo dor-m&#233;dico e m&#233;dico-dispositivo sendo este &#250;ltimo imputado &#224; organiza&#231;&#227;o interna dos hospitais&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Nesta popula&#231;&#227;o apenas uma minoria de doentes com enfarte do mioc&#225;rdio com supradesnivelamento ST foram revascularizados dentro da janela temporal recomendada&#46; A responsabilidade nos atrasos observados parece ser multifatorial&#44; relacionada n&#227;o s&#243; com uma atitude inadequada dos doentes aquando do seu primeiro pedido de ajuda&#44; como podendo ser atribu&#237;da a aspetos organizacionais dos diferentes sistemas de sa&#250;de envolvidos&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflito de interesses</span><p id="par0135" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflito de interesses&#46;</p></span></span>"
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    "fechaRecibido" => "2011-06-15"
    "fechaAceptado" => "2012-04-23"
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            0 => "Angioplastia prim&#225;ria"
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        "titulo" => "Resumo"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introdu&#231;&#227;o</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Segundo as recomenda&#231;&#245;es atuais para o tratamento do enfarte agudo do mioc&#225;rdio com supra-desnivelamento do segmento ST a interven&#231;&#227;o coron&#225;ria percut&#226;nea deve ser efetuada dentro de 90<span class="elsevierStyleHsp" style=""></span>min ap&#243;s o primeiro contacto m&#233;dico e o tempo total de isqu&#233;mia n&#227;o deve exceder os 120<span class="elsevierStyleHsp" style=""></span>min&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">O objetivo deste trabalho foi analisar a adequa&#231;&#227;o da implementa&#231;&#227;o destas recomenda&#231;&#245;es para o enfarte do mioc&#225;rdio com supra-desnivelamento do segmento ST num centro terci&#225;rio de interven&#231;&#227;o coron&#225;ria percut&#226;nea&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Registo prospetivo de centro &#250;nico de 223 doentes consecutivos referenciados para interven&#231;&#227;o coron&#225;ria percut&#226;nea prim&#225;ria entre 2003 e 2007&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nesta popula&#231;&#227;o &#40;idade m&#233;dia 60<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 anos&#44; 76&#37; de sexo masculino&#41;&#44; a mediana do tempo total de isqu&#233;mia foi 4<span class="elsevierStyleHsp" style=""></span>h 30<span class="elsevierStyleHsp" style=""></span>min &#40;&#60; 120<span class="elsevierStyleHsp" style=""></span>min em 4&#37; dos doentes&#41;&#46; O intervalo de tempo com menor atraso foi desde o primeiro contacto m&#233;dico at&#233; &#224; realiza&#231;&#227;o do ECG &#40;mediana 8<span class="elsevierStyleHsp" style=""></span>min&#44; &#60;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>min em 59&#37; dos doentes&#41;&#46; Os intervalos com maior atraso foram&#58; do in&#237;cio dos sintomas ao primeiro contacto m&#233;dico &#40;mediana 104<span class="elsevierStyleHsp" style=""></span>min&#44; &#60;<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min em 6&#37; dos doentes&#41; e do primeiro ECG &#224; realiza&#231;&#227;o da interven&#231;&#227;o coron&#225;ria &#40;mediana 140<span class="elsevierStyleHsp" style=""></span>min&#44; &#60;<span class="elsevierStyleHsp" style=""></span>90<span class="elsevierStyleHsp" style=""></span>min em 16&#37; dos doentes&#41;&#46; O menor tempo total de isqu&#233;mia associou-se a melhor fluxo TIMI final&#44; melhor TIMI <span class="elsevierStyleItalic">frame count</span> final e maior resolu&#231;&#227;o do segmento ST ap&#243;s angioplastia &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#41;&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">As tr&#234;s origens mais frequentes dos doentes foram&#58; dois hospitais de localidades pr&#243;ximas e o sistema de emerg&#234;ncia m&#233;dica pr&#233;-hospitalar&#46; No grupo pr&#233;-hospitalar verificou-se menor tempo total de isqu&#233;mia do que nos hospitais A ou B &#40;2<span class="elsevierStyleHsp" style=""></span>h 45<span class="elsevierStyleHsp" style=""></span>min <span class="elsevierStyleItalic">versus</span> 4<span class="elsevierStyleHsp" style=""></span>h 44<span class="elsevierStyleHsp" style=""></span>min e 6<span class="elsevierStyleHsp" style=""></span>h 40<span class="elsevierStyleHsp" style=""></span>min&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#44; com menor tempo desde o primeiro contacto m&#233;dico at&#233; &#224; angioplastia &#40;89<span class="elsevierStyleHsp" style=""></span>min <span class="elsevierStyleItalic">versus</span> 147 e 146<span class="elsevierStyleHsp" style=""></span>min&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclus&#227;o</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Nesta popula&#231;&#227;o&#44; apenas uma reduzida percentagem de doentes com enfarte agudo do mioc&#225;rdio obteve tratamento adequado por angioplastia prim&#225;ria dentro dos tempos recomendados&#46; Os doentes referenciados pelo sistema de emerg&#234;ncia pr&#233;-hospitalar&#44; embora em reduzida percentagem do total&#44; foram os que obtiveram os melhores resultados na precocidade do tratamento&#46; O cumprimento das recomenda&#231;&#245;es traduz-se em melhores resultados na perfus&#227;o mioc&#225;rdica obtida pela angioplastia prim&#225;ria&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">According to the current guidelines for treatment of ST-elevation myocardial infarction &#40;STEMI&#41;&#44; percutaneous coronary intervention &#40;PCI&#41; should be performed within 90<span class="elsevierStyleHsp" style=""></span>min of first medical contact and total ischemic time should not exceed 120<span class="elsevierStyleHsp" style=""></span>min&#46; The aim of this study was to analyze compliance with STEMI guidelines in a tertiary PCI center&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">This was a prospective single-center registry of 223 consecutive STEMI patients referred for primary PCI between 2003 and 2007&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">In this population &#40;mean age 60<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 years&#44; 76&#37; male&#41;&#44; median total ischemic time was 4<span class="elsevierStyleHsp" style=""></span>h 30<span class="elsevierStyleHsp" style=""></span>min &#40;&#60;120<span class="elsevierStyleHsp" style=""></span>min in 4&#37; of patients&#41;&#46; The interval with the best performance was first medical contact to first ECG &#40;median 8<span class="elsevierStyleHsp" style=""></span>min&#44; &#60;10<span class="elsevierStyleHsp" style=""></span>min in 59&#37; of patients&#41;&#46; The worst intervals were symptom onset to first medical contact &#40;median 104<span class="elsevierStyleHsp" style=""></span>min&#44; &#60;30<span class="elsevierStyleHsp" style=""></span>min in 6&#37;&#41; and first ECG to PCI &#40;median 140<span class="elsevierStyleHsp" style=""></span>min&#44; &#60;90<span class="elsevierStyleHsp" style=""></span>min in 16&#37;&#41;&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Shorter total ischemic time was associated with better post-PCI TIMI flow&#44; TIMI frame count and ST-segment resolution &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#41;&#46; The three most common patient origins were two nearby hospitals &#40;A and B&#41; and the pre-hospital emergency system&#46; The pre-hospital group had shorter total ischemic time than patients from hospitals A or B &#40;2<span class="elsevierStyleHsp" style=""></span>h 45<span class="elsevierStyleHsp" style=""></span>min vs&#46; 4<span class="elsevierStyleHsp" style=""></span>h 44<span class="elsevierStyleHsp" style=""></span>min and 6<span class="elsevierStyleHsp" style=""></span>h 40<span class="elsevierStyleHsp" style=""></span>min&#44; respectively&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#44; with shorter door-to-balloon time &#40;89<span class="elsevierStyleHsp" style=""></span>min vs&#46; 147<span class="elsevierStyleHsp" style=""></span>min and 146<span class="elsevierStyleHsp" style=""></span>min&#44; respectively&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">In this population&#44; only a small proportion of patients with acute myocardial infarction underwent primary PCI within the recommended time&#46; Patients referred through the pre-hospital emergency system&#44; although a minority&#44; had the best results in terms of early treatment&#46; Compliance with the guidelines translates into better myocardial perfusion achieved through primary PCI&#46;</p>"
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          "pt" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Modo de transporte dos doentes para um primeiro hospital sem capacidade de ICP&#46;</p> <p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Ambul&#226;ncia&#58; ambul&#226;ncia sem m&#233;dico &#40;sistema de emerg&#234;ncia pr&#233;-hospitalar ou privada&#41;&#59; Ambul&#226;ncia com m&#233;dico&#58; ambul&#226;ncia com m&#233;dico &#40;sistema de emerg&#234;ncia pr&#233;-hospitalar&#41;&#46;</p>"
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                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>34<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Centro ICP-dispositivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ECG-Dispositivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>20<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>03<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#233;dico-dispositivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>20<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tempo total de isqu&#233;mia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab354917.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Mediana dos tempos observados comparados com o m&#225;ximo recomendado na popula&#231;&#227;o total</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">&#60; Max &#40;&#37;&#41;&#58; percentagem de doentes em que o tempo observado foi inferior ao m&#225;ximo recomendado&#59; Centro ICP-dispositivo&#58; desde a chegada ao centro com capacidade para ICP at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o&#59; Dor-m&#233;dico&#58; desde o in&#237;cio dos sintomas at&#233; ao primeiro contacto m&#233;dico&#59; ECG-centro ICP&#58; desde a realiza&#231;&#227;o do ECG diagn&#243;stico at&#233; &#224; chegada ao centro com capacidade de ICP&#59; ECG-dispositivo&#58; desde a realiza&#231;&#227;o do ECG diagn&#243;stico at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o&#59; M&#233;dico-dispositivo&#58; desde o primeiro contacto m&#233;dico at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o&#59; M&#233;dico-ECG&#58; desde o primeiro contacto m&#233;dico at&#233; &#224; realiza&#231;&#227;o do ECG diagn&#243;stico&#59; Obs&#46;&#58; Observado&#59; Tempo total de isquemia&#58; desde o in&#237;cio dos sintomas at&#233; &#224; utiliza&#231;&#227;o do primeiro dispositivo de revasculariza&#231;&#227;o&#59; TR Max&#58; tempo m&#225;ximo recomendado&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TR Max&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Pre-Hosp</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Hosp-A</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Hosp-B</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Obs&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#60; TR Max &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Obs&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#60; TR Max &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Obs&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#60; TR Max &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dor-m&#233;dico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>47<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>32<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#233;dico-ECG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>07<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">71&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>13<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>06<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ECG-centro ICP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>36<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>46<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>39<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Centro ICP-dispositivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>44<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>27<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>24<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ECG-Dispositivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>20min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>22min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>20<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>22<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#233;dico-dispositivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>29min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>27<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>26<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tempo total de isqu&#233;mia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>00<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>45<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>44<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Mediana dos tempos observados comparados com o m&#225;ximo recomendado de acordo com a proveni&#234;ncia dos doentes</p>"
        ]
      ]
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        "etiqueta" => "Tabela 3"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">TIMI&#58; fluxo TIMI p&#243;s ICP&#59; <span class="elsevierStyleItalic">TIMI Frame Count</span>&#58; <span class="elsevierStyleItalic">TIMI Frame Count</span> corrigido p&#243;s-ICP&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Tempo total de isqu&#233;mia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">TIMI 2 <span class="elsevierStyleItalic">versus</span> 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>03<span class="elsevierStyleHsp" style=""></span>m <span class="elsevierStyleItalic">versus</span> 4<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>17<span class="elsevierStyleHsp" style=""></span>m&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TIMI <span class="elsevierStyleItalic">Frame count</span> &#62;<span class="elsevierStyleHsp" style=""></span>24 <span class="elsevierStyleItalic">versus</span> &#8804; 24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>00<span class="elsevierStyleHsp" style=""></span>m <span class="elsevierStyleItalic">versus</span> 4<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>11<span class="elsevierStyleHsp" style=""></span>m&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resolu&#231;&#227;o de ST &#60;<span class="elsevierStyleHsp" style=""></span>70 <span class="elsevierStyleItalic">versus</span> &#8805;<span class="elsevierStyleHsp" style=""></span>70&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>12<span class="elsevierStyleHsp" style=""></span>m <span class="elsevierStyleItalic">versus</span> 3<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>59<span class="elsevierStyleHsp" style=""></span>m&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;002&nbsp;\t\t\t\t\t\t\n
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                  """
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                0 => "xTab354916.png"
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        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Mediana do tempo total de isqu&#233;mia observado de acordo com marcadores indiretos de sucesso da ICP</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliografia"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:18 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction&#58; a quantitative review of 23 randomised trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46;C&#46; Keeley"
                            1 => "J&#46;A&#46; Boura"
                            2 => "C&#46;L&#46; Grines"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(03)12113-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2003"
                        "volumen" => "361"
                        "paginaInicial" => "13"
                        "paginaFinal" => "20"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12517460"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of door-to-balloon time and mortality in patients admitted to hospital with ST elevation myocardial infarction&#58; national cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;S&#46; Rathore"
                            1 => "J&#46;P&#46; Curtis"
                            2 => "J&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2009"
                        "volumen" => "338"
                        "paginaInicial" => "b1807"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19454739"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Time delay to treatment and mortality in primary angioplasty for acute myocardial infarction&#58; every minute of delay counts"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; De Luca"
                            1 => "H&#46; Suryapranata"
                            2 => "J&#46;P&#46; Ottervanger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR.0000121424.76486.20"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2004"
                        "volumen" => "109"
                        "paginaInicial" => "1223"
                        "paginaFinal" => "1225"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15007008"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation&#58; the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "F&#46; Van de Werf"
                            1 => "J&#46; Bax"
                            2 => "A&#46; Betriu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2008"
                        "paginaInicial" => "2909"
                        "paginaFinal" => "2945"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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