array:24 [
  "pii" => "S0870255112001138"
  "issn" => "08702551"
  "doi" => "10.1016/j.repc.2011.11.012"
  "estado" => "S300"
  "fechaPublicacion" => "2012-07-01"
  "aid" => "119"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "sco"
  "cita" => "Rev Port Cardiol. 2012;31:517-20"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 7705
    "formatos" => array:3 [
      "EPUB" => 195
      "HTML" => 6240
      "PDF" => 1270
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S087025511200128X"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2012.05.006"
    "estado" => "S300"
    "fechaPublicacion" => "2012-07-01"
    "aid" => "122"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Rev Port Cardiol. 2012;31:521-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6023
      "formatos" => array:3 [
        "EPUB" => 195
        "HTML" => 4458
        "PDF" => 1370
      ]
    ]
    "pt" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Caso Cl&#237;nico</span>"
      "titulo" => "Assist&#234;ncia ventricular esquerda numa crian&#231;a de 5 anos &#8211; ponte para recupera&#231;&#227;o num caso de miocardite viral"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => "pt"
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "521"
          "paginaFinal" => "524"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Left ventricular assist device in a five-year-old child&#58; A bridge to recovery in a case of viral myocarditis"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1069
              "Ancho" => 1257
              "Tamanyo" => 100031
            ]
          ]
          "descripcion" => array:1 [
            "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Melhoria gradual da fun&#231;&#227;o card&#237;aca e diminui&#231;&#227;o da dilata&#231;&#227;o do ventr&#237;culo esquerdo ap&#243;s in&#237;cio de assist&#234;ncia ventricular&#46; As setas pretas indicam&#44; da esquerda para a direita&#44; implanta&#231;&#227;o e retirada da assist&#234;ncia ventricular externa&#46; AVE&#58; assist&#234;ncia ventricular externa&#59; FEVE&#58; fra&#231;&#227;o de eje&#231;&#227;o&#59; FencVE&#58; fra&#231;&#227;o de encurtamento&#59; VEd&#58; di&#226;metro do ventr&#237;culo esquerdo em di&#225;stole&#59; VTI&#58; integral velocidade tempo na c&#226;mara de sa&#237;da do ventr&#237;culo esquerdo&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Margarida Silva, Nuno Carvalho, Gra&#231;a Nogueira, Patr&#237;cia Costa, Rui Rodrigues, Miguel Abecasis, Manuela Nunes, Rui Anjos, Jos&#233; Neves"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "Margarida"
              "apellidos" => "Silva"
            ]
            1 => array:2 [
              "nombre" => "Nuno"
              "apellidos" => "Carvalho"
            ]
            2 => array:2 [
              "nombre" => "Gra&#231;a"
              "apellidos" => "Nogueira"
            ]
            3 => array:2 [
              "nombre" => "Patr&#237;cia"
              "apellidos" => "Costa"
            ]
            4 => array:2 [
              "nombre" => "Rui"
              "apellidos" => "Rodrigues"
            ]
            5 => array:2 [
              "nombre" => "Miguel"
              "apellidos" => "Abecasis"
            ]
            6 => array:2 [
              "nombre" => "Manuela"
              "apellidos" => "Nunes"
            ]
            7 => array:2 [
              "nombre" => "Rui"
              "apellidos" => "Anjos"
            ]
            8 => array:2 [
              "nombre" => "Jos&#233;"
              "apellidos" => "Neves"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087025511200128X?idApp=UINPBA00004E"
    "url" => "/08702551/0000003100000078/v1_201308021259/S087025511200128X/v1_201308021259/pt/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0870255112001126"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2011.11.011"
    "estado" => "S300"
    "fechaPublicacion" => "2012-07-01"
    "aid" => "118"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Rev Port Cardiol. 2012;31:513-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6650
      "formatos" => array:3 [
        "EPUB" => 201
        "HTML" => 5203
        "PDF" => 1246
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Cardiac thrombus and conduction disorder in takotsubo cardiomyopathy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "513"
          "paginaFinal" => "516"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Miocardiopatia de takotsubo complicada com trombo apical e altera&#231;&#245;es da condu&#231;&#227;o"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 978
              "Ancho" => 3000
              "Tamanyo" => 256630
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Results of cardiac catheterization&#46; Left ventriculography at end-systole &#40;A&#41; and end-diastole &#40;B&#41; demonstrating typical apical ballooning and double outline apex suggestive of apical thrombus&#46; Results of selective coronary angiography of the left main coronary artery &#40;C&#41; showing no significant stenosis&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ana Sofia Correia, Nuno Moreno, Alexandra Gon&#231;alves, V&#237;tor Ara&#250;jo, Teresa Pinho, Rui Andr&#233; Rodrigues, Filipe Macedo, Maria J&#250;lia Maciel"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Ana Sofia"
              "apellidos" => "Correia"
            ]
            1 => array:2 [
              "nombre" => "Nuno"
              "apellidos" => "Moreno"
            ]
            2 => array:2 [
              "nombre" => "Alexandra"
              "apellidos" => "Gon&#231;alves"
            ]
            3 => array:2 [
              "nombre" => "V&#237;tor"
              "apellidos" => "Ara&#250;jo"
            ]
            4 => array:2 [
              "nombre" => "Teresa"
              "apellidos" => "Pinho"
            ]
            5 => array:2 [
              "nombre" => "Rui Andr&#233;"
              "apellidos" => "Rodrigues"
            ]
            6 => array:2 [
              "nombre" => "Filipe"
              "apellidos" => "Macedo"
            ]
            7 => array:2 [
              "nombre" => "Maria J&#250;lia"
              "apellidos" => "Maciel"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255112001126?idApp=UINPBA00004E"
    "url" => "/08702551/0000003100000078/v1_201308021259/S0870255112001126/v1_201308021259/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
    "titulo" => "Fulminant myocarditis associated with pandemic H1N1 influenza A virus"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "517"
        "paginaFinal" => "520"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Marta Cabral, Maria J&#46; Brito, Marta Conde, M&#225;rio Oliveira, Gon&#231;alo C&#46; Ferreira"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Marta"
            "apellidos" => "Cabral"
            "email" => array:1 [
              0 => "mssr&#46;cabral&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Maria J&#46;"
            "apellidos" => "Brito"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Marta"
            "apellidos" => "Conde"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "M&#225;rio"
            "apellidos" => "Oliveira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Gon&#231;alo C&#46;"
            "apellidos" => "Ferreira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Department of Pediatrics&#44; Hospital Dona Estef&#226;nia &#8211; CHLC &#8211; EPE&#44; Lisbon&#44; Portugal"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Department of Pathology&#44; Hospital de S&#227;o Jos&#233; &#8211; CHLC &#8211; EPE&#44; Lisbon&#44; Portugal"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Miocardite fulminante associada ao v&#237;rus influenza A pand&#233;mico H1N1"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2354
            "Ancho" => 1584
            "Tamanyo" => 331795
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Intermediate &#40;A&#41; and high &#40;B&#41; magnification of myocardium with multifocal infiltrates composed mostly of lymphocytes but also some neutrophils&#44; macrophages&#44; plasma cells and eosinophils&#44; associated with myocyte necrosis and ischemia&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Acute myocarditis&#44; albeit rare and potentially lethal&#44; is a well-recognized manifestation of numerous viral infections with a broad spectrum of symptoms and clinical features&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The etiological agents of viral myocarditis include enteroviruses&#44; adenoviruses&#44; parvoviruses&#44; hepatitis C virus&#44; human immunodeficiency virus&#44; influenza&#44; and others&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Coxsackie B virus has been described as the most common pathogen of viral myocarditis and hepatitis C virus is associated with many different forms of heart disease worldwide&#59; however&#44; influenza myocarditis is relatively rare&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> Many people are affected by seasonal influenza every year&#44; but the myocarditogenicity of this virus seems to be fairly low&#46; The frequency of myocardial involvement in influenza infection is unclear&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> but some studies report that it ranges from 0 to 11&#37;&#44; depending on the diagnostic criteria used to define myocarditis&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Myocarditis is an inflammatory disorder characterized by myocyte necrosis and inflammatory infiltrate of the myocardium&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> The pathogenesis of influenza myocarditis is also unclear&#46; Host immune response may play a role&#44; as well as direct cytolysis by viral infection&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Fulminant myocarditis is an uncommon complication&#44; typically diagnosed in association with circulatory collapse or at autopsy in patients with influenza-associated fatal outcomes&#46; It may present with fatal arrhythmias&#44; atrioventricular block and&#47;or varying degrees of heart failure&#44; cardiogenic shock being the most severe&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A few case reports and series present incidental diagnoses of influenza-associated acute fulminant myocarditis&#44; but the true prevalence remains unknown&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> We present a case of rapidly fatal fulminant pandemic influenza A &#40;H1N1&#41; virus &#40;H1N1v&#41;-associated myocarditis&#44; with no previous cardiac symptomatology&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case report</span><p id="par0020" class="elsevierStylePara elsevierViewall">A previously healthy 10-year-old boy presented to the emergency department with a three-day history of a flu-like syndrome&#58; fever&#44; cough&#44; headache&#44; generalized myalgia&#44; vomiting and diarrhea&#46; He had no known risk factors for complications of influenza&#44; he was not previously vaccinated for seasonal or pandemic influenza viruses and he was not receiving any antiviral treatment&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">At admission&#44; he was pale and had signs of dehydration&#46; Body temperature was 34&#46;7<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; pulse rate 120<span class="elsevierStyleHsp" style=""></span>beats&#47;min and blood pressure 84&#47;65<span class="elsevierStyleHsp" style=""></span>mmHg &#40;median arterial pressure&#58; 65<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#46; Pulse oximetry showed oxygen saturation of 96&#8211;98&#37; and cardiac physical examination was normal&#46; Chest radiography revealed diffuse bilateral alveolar infiltrates&#46; Laboratory findings included 11<span class="elsevierStyleHsp" style=""></span>300<span class="elsevierStyleHsp" style=""></span>leukocytes&#47;mm<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> &#40;84&#46;5&#37; neutrophils&#41;&#44; C-reactive protein 2&#46;41<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; and elevated creatinine &#40;1&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#44; glucose &#40;217<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; and phosphorus &#40;8&#46;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#44; with no other abnormalities&#46; The patient&#39;s clinical condition improved significantly after intravenous fluid administration&#59; however&#44; when he was hemodynamically stable&#44; sudden asystolic cardiac arrest occurred&#46; Advanced life support was immediately started but was ineffective and the patient died&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Further investigation showed mild elevation of CK&#44; CK-MB and myoglobin&#46; Reverse transcriptase polymerase chain reaction assay from nasopharyngeal swab samples was positive for H1N1v&#46; The autopsy showed multifocal infiltrates composed mostly of lymphocytes but also some neutrophils&#44; macrophages&#44; plasma cells and eosinophils&#44; associated with myocyte necrosis and ischemia&#44; which was compatible with myocarditis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41; and excluded the diagnosis of hypertrophic cardiomyopathy&#46; The lung tissue specimen obtained at autopsy showed diffuse pulmonary vascular congestion and extensive alveolar hemorrhage &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46; Additionally&#44; multisystem histological changes including the cardiac and pulmonary alterations described above&#44; and tracheobronchial and intestinal involvement associated with viral infection were evident&#44; leading to a definite postmortem diagnosis of fulminant viral myocarditis&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">The prevalence of fulminant myocarditis associated with H1N1v is unknown because of the lack of comprehensive screening&#44; with only a handful of case reports and autopsy findings in the literature&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Bratincsak et al&#46; reported four fulminant myocarditis cases associated with H1N1v in children and suggested that the 2009 pandemic influenza virus was more commonly associated with myocarditis than seasonal influenza&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The Japanese pandemic influenza registry reported 15 patients with H1N1v-associated myocarditis&#44; ranging from a child to a man over 70 years old&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> According to a report from Canada&#44; only two of 505 children hospitalized with severe influenza infection had myocarditis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> There are few individual case reports of fulminant myocarditis from the USA and Europe&#44;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#8211;12</span></a> and a single fatal case was reported in a multicenter pediatric study conducted in Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> This is the first report in Portugal&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Common cardiac symptoms of myocarditis include dyspnea&#44; chest discomfort&#44; hypotension&#44; peripheral edema and syncope&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In the case of myocarditis caused by H1N1v&#44; clinical manifestations vary greatly&#46; Ukimura et al&#46; reported that cardiac dysfunction had progressed rapidly in 12 out of 15 patients&#44; and developed after recovery from flu-like symptoms in two patients&#46; Ten patients with fulminant myocarditis had fatal arrhythmias and&#47;or cardiogenic shock&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Cardiopulmonary arrest as the first cardiac symptom was described in only two patients&#44; as happened with our patient&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Small autopsy-based studies have shown complication rates of myocarditis in fatal cases of 39&#46;4&#37; with Asian flu and 48&#37; with Spanish flu&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> All these fatal cases with myocarditis had severe pneumonia and multiple organ involvement&#44; implying that myocarditis was likely to be a terminally ill state of influenza infection&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> as could have been the case with our patient&#44; according to the histopathological findings on autopsy &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figures 1 and 2</a>&#41;&#46; By contrast&#44; severe viral pneumonia did not precede myocarditis in the 15 cases reported by Ukimura et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Some patients complained only of high fever&#44; without respiratory symptoms before the onset of myocarditis&#46; The findings imply that the H1N1v may have a high affinity for heart tissue in some susceptible patients&#46; In this patient there was initially thought to be an underlying cardiac disease &#40;hypertrophic cardiomyopathy&#41;&#44; which could have increased his susceptibility to cardiac complications&#44; but this comorbidity was excluded by histopathology findings&#46; Despite the presence of tachycardia&#44; hypotension and hypothermia secondary to dehydration at admission&#44; the patient was hemodynamically stable immediately before asystolic cardiac arrest and death&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Data on the clinical benefits of antiviral treatment for H1N1v are limited and different authorities have different recommendations&#46; The Hong Kong Hospital Authority Central Committee on Infectious Disease and Emergency Responses &#40;CCIDER&#41; recommend that empirical antiviral treatment be started immediately in patients who are at higher risk for developing complications&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> including those younger than six years&#44; morbidly obese&#44; asthmatic&#44; immunocompromised or pregnant subjects&#44; patients showing no improvement in symptoms 48<span class="elsevierStyleHsp" style=""></span>h after medical treatment and in patients in whom H1N1v infection has been confirmed&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> There are compelling indications for the use of beta blockers and&#47;or angiotensin-converting enzyme inhibitors for the treatment of a subacute phase of the illness&#59; additional supportive intervention is essential as first-line therapy for myocarditis patients with heart failure&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The recent application of intra-aortic balloon pump and&#47;or veno-venous extracorporeal membrane oxygenation &#40;ECMO&#41; in serious cases has yielded good outcomes&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;16&#44;17</span></a> but in this case&#44; despite aggressive management&#44; circulatory resuscitation was not successful&#46; This patient did not receive antiviral treatment&#44; which has been convincingly shown to decrease morbidity and mortality in H1N1v infection&#46; However&#44; as this was a case of fulminant evolution&#44; with rapid progression of inflammatory infiltration&#44; antiviral treatment probably would not have had sufficient time to be effective&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Early detection of myocarditis in patients during influenza pandemics is difficult&#44; as there are no specific symptoms or signs&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> To avoid misdiagnosis it is essential to determine the characteristic symptoms&#44; signs and laboratory findings of acute myocarditis&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> but it is also important to remember that it can occur suddenly&#44; without any previous suspicious symptom or sign&#44; as was seen in our patient&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">This was the first death in the Portuguese pediatric population during the 2009 H1N1v pandemic&#44; and provided arguments for more stringent indications for antiviral therapy in the context of influenza pandemics&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusion</span><p id="par0070" class="elsevierStylePara elsevierViewall">The fulminant form of myocarditis associated with H1N1v may present in the form of fatal arrhythmia&#44; atrioventricular block and&#47;or cardiogenic shock&#44; usually diagnosed in the context of circulatory collapse or autopsy in patients with H1N1v infection&#44; as occurred in this patient&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">As the incidence of H1N1v infection continues to rise&#44; physicians should be aware of this rare and potentially fatal complication&#44; since early diagnosis and aggressive supportive measures are essential&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:2 [
          "identificador" => "xres250452"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec238020"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres250451"
          "titulo" => "Resumo"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec238019"
          "titulo" => "Palavras-chave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Case report"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Conclusion"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflict of interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2011-10-01"
    "fechaAceptado" => "2011-11-30"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec238020"
          "palabras" => array:4 [
            0 => "Influenza"
            1 => "H1N1"
            2 => "Fulminant"
            3 => "Myocarditis"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec238019"
          "palabras" => array:4 [
            0 => "Influenza"
            1 => "H1NI"
            2 => "Fulminante"
            3 => "Miocardite"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Fulminant myocarditis associated with influenza A virus is exceedingly rare&#44; with only a few cases reported in the literature&#46; We describe a previously healthy 10-year-old boy&#44; with a three-day history of flu-like symptoms without antiviral treatment&#46; He was hospitalized with dehydration and hypothermia in the context of persistent vomiting&#44; when he suddenly developed heart failure secondary to fulminant myocarditis&#46; Despite aggressive management&#44; including circulatory support and cardiopulmonary resuscitation measures&#44; the patient died of cardiogenic shock&#46; The postmortem histopathology was compatible with a multisystem viral infection with myocarditis and pulmonary involvement&#44; and H1N1v polymerase chain reaction was positive&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The prevalence of influenza-associated fulminant myocarditis remains unknown&#46; Findings reported in the literature raise the possibility that the novel H1N1 influenza A virus is more commonly associated with a severe form of myocarditis than previously encountered influenza strains&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A miocardite fulminante associada ao v&#237;rus Influenza A &#233; extremamente rara&#44; com apenas alguns casos relatados na literatura&#46; Descrevemos um rapaz de 10 anos&#44; previamente saud&#225;vel&#44; com hist&#243;ria de sintomas gripais com 3 dias de evolu&#231;&#227;o&#44; sem terap&#234;utica antiviral&#46; Foi internado por desidrata&#231;&#227;o e hipotermia&#44; no contexto de v&#243;mitos persistentes ap&#243;s o que&#44; subitamente&#44; desenvolveu insufici&#234;ncia card&#237;aca secund&#225;ria a miocardite fulminante&#46; Apesar da interven&#231;&#227;o imediata&#44; incluindo suporte circulat&#243;rio e reanima&#231;&#227;o cardiorrespirat&#243;ria&#44; o doente faleceu por choque cardiog&#233;nico&#46; O exame histopatol&#243;gico <span class="elsevierStyleItalic">post-mortem</span> foi compat&#237;vel com o diagn&#243;stico de infec&#231;&#227;o viral multissist&#233;mica&#44; com miocardite e envolvimento pulmonar e a PCR para o H1N1<span class="elsevierStyleHsp" style=""></span>v foi positiva&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A preval&#234;ncia de miocardite fulminante associada ao v&#237;rus Influenza permanece desconhecida&#46; Relatos na literatura levantam a hip&#243;tese de o v&#237;rus Influenza A H1N1 estar mais frequentemente associado a formas graves de miocardite do que as estirpes sazonais anteriores&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2379
            "Ancho" => 1584
            "Tamanyo" => 492974
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Low &#40;A&#41; and intermediate &#40;B&#41; magnification of pulmonary parenchyma with vascular congestion and multiple foci of alveolar hemorrhage&#44; without associated inflammation&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2354
            "Ancho" => 1584
            "Tamanyo" => 331795
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Intermediate &#40;A&#41; and high &#40;B&#41; magnification of myocardium with multifocal infiltrates composed mostly of lymphocytes but also some neutrophils&#44; macrophages&#44; plasma cells and eosinophils&#44; associated with myocyte necrosis and ischemia&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:17 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fulminant myocarditis associated with pandemic H1N1 influenza A virus in children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Bratincsak"
                            1 => "H&#46; El-said"
                            2 => "J&#46; Bradley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2010.01.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2010"
                        "volumen" => "55"
                        "paginaInicial" => "928"
                        "paginaFinal" => "929"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20153131"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical Research Committee on Myocarditis Associated with the 2009 Influenza A &#40;H1N1&#41; Pandemic in Japan organized by the Japanese Circulation Society&#46; A National Survey on Myocarditis Associated with the 2009 Influenza A &#40;H1N1&#41; Pandemic in Japan"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Ukimura"
                            1 => "T&#46; Izumi"
                            2 => "A&#46; Matsumori"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circ J"
                        "fecha" => "2010"
                        "volumen" => "74"
                        "paginaInicial" => "2193"
                        "paginaFinal" => "2199"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20697177"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Coxsackevirus myocarditis&#58; interplay between virus and host in the pathogenesis of heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Tam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/vim.2006.19.133"
                      "Revista" => array:6 [
                        "tituloSerie" => "Viral Immunol"
                        "fecha" => "2006"
                        "volumen" => "19"
                        "paginaInicial" => "133"
                        "paginaFinal" => "146"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16817756"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Global alert and response network for hepatitis C virus-derived heart diseases&#58; a call to action"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Matsumori"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "CVD Prevent Control"
                        "fecha" => "2009"
                        "volumen" => "4"
                        "paginaInicial" => "109"
                        "paginaFinal" => "118"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influenza myocarditis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Kodama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circ J"
                        "fecha" => "2010"
                        "volumen" => "74"
                        "paginaInicial" => "2060"
                        "paginaFinal" => "2061"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20838004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular manifestations associated with influenza virus infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Mamas"
                            1 => "D&#46; Fraser"
                            2 => "L&#46; Neyses"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijcard.2008.04.044"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cardiol"
                        "fecha" => "2008"
                        "volumen" => "130"
                        "paginaInicial" => "304"
                        "paginaFinal" => "309"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18625525"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of myocarditis mimicking acute coronary syndrome associated with H1N1 influenza A virus infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Sahin"
                            1 => "M&#46; Demir"
                            2 => "B&#46; Kurtaran"
                            3 => "A&#46; Usal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Turk Soc Cardiol"
                        "fecha" => "2010"
                        "volumen" => "38"
                        "paginaInicial" => "572"
                        "paginaFinal" => "575"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fulminant fatal swine influenza &#40;H1N1&#41;&#58; myocarditis&#44; myocardial infarction&#44; or severe influenza pneumonia&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46; Cunha"
                            1 => "U&#46; Syed"
                            2 => "N&#46; Mickail"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.hrtlng.2010.04.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Heart Lung"
                        "fecha" => "2010"
                        "volumen" => "39"
                        "paginaInicial" => "453"
                        "paginaFinal" => "458"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20831976"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fulminant myocarditis associated with novel H1N1 influenza A"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Khouzam"
                            1 => "C&#46; Parizianu"
                            2 => "A&#46; Hafiz"
                            3 => "S&#46; Chawla"
                            4 => "R&#46; Schwartz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Heart Lung"
                        "fecha" => "2011"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3882636"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Myocarditis in a juvenile patient with influenza A virus infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Weiss"
                            1 => "H&#46; Knut"
                            2 => "K&#46; Stensaeth"
                            3 => "J&#46; Eritsland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurheartj/ehp566"
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2010"
                        "volumen" => "31"
                        "paginaInicial" => "277"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20007610"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Myocarditis due to pandemic influenza A &#40;H1N1&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Penela"
                            1 => "A&#46; Regueiro-Cueva"
                            2 => "J&#46;T&#46; Ortiz-P&#233;rez"
                            3 => "M&#46; Sitges"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Cardiol"
                        "fecha" => "2010"
                        "volumen" => "63"
                        "paginaInicial" => "1386"
                        "paginaFinal" => "1387"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21070738"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fulminant myocarditis due to H1N1 influenza"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Al-Ammodi"
                            1 => "K&#46; Rao"
                            2 => "S&#46; Rao"
                            3 => "J&#46; Brewer"
                            4 => "A&#46; Maglski"
                            5 => "A&#46; Chhatriwalla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCHEARTFAILURE.109.884395"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circ Heart Fail"
                        "fecha" => "2010"
                        "volumen" => "3"
                        "paginaInicial" => "7"
                        "paginaFinal" => "9"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20009044"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Caracter&#237;sticas cl&#237;nicas de la gripe A H1N1 2009&#58; est&#250;dio multic&#233;ntrico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Muga"
                            1 => "N&#46; Monmany"
                            2 => "S&#46; Carretero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "An Pediatr"
                        "fecha" => "2011"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "HA Central Committee on Infectious Disease and Emergency Responses &#40;CCIDER&#41;&#46; Interim guideline on antiviral treatment&#44; chemoprophylaxis and pneumococcal vaccination for human swine influenza&#47;influenza A &#40;H1N1&#41; Infection&#46; 21 Oct 2009&#46; Available from&#58; <a class="elsevierStyleInterRef" href="http://www.ha.org.hk/haho/ho/hsflu/Interim_Treatment_091021.pdf">http&#58;&#47;&#47;www&#46;ha&#46;org&#46;hk&#47;haho&#47;ho&#47;hsflu&#47;Interim&#95;Treatment&#95;091021&#46;pdf</a>&#46;"
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Bartlett&#44; J&#46; H1N1 Influenza &#8211; just the facts&#58; clinical features and epidemiology&#46; 2009&#46; Available from&#58; <a class="elsevierStyleInterRef" href="http://www.medscape.com/viewarticle/709540">http&#58;&#47;&#47;www&#46;medscape&#46;com&#47;viewarticle&#47;709540</a>&#46;"
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A child with influenza A &#40;H1N1&#41;-associated myocarditis rescued by extracorporeal membrane oxygenation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46; Oda"
                            1 => "H&#46; Yasunaga"
                            2 => "Y&#46; Tsutsumi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10047-010-0523-y"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Artif Organs"
                        "fecha" => "2010"
                        "volumen" => "13"
                        "paginaInicial" => "232"
                        "paginaFinal" => "234"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21088859"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influenza myocarditis and myositis&#58; case presentation and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Kumar"
                            1 => "M&#46; Guirgis"
                            2 => "S&#46; Zieroth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cjca.2011.03.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Can J Cardiol"
                        "fecha" => "2011"
                        "volumen" => "27"
                        "paginaInicial" => "514"
                        "paginaFinal" => "522"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21652168"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/08702551/0000003100000078/v1_201308021259/S0870255112001138/v1_201308021259/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "362"
    "tipo" => "SECCION"
    "pt" => array:2 [
      "titulo" => "Casos cl&#237;nicos"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "pt"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08702551/0000003100000078/v1_201308021259/S0870255112001138/v1_201308021259/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255112001138?idApp=UINPBA00004E"
]
Partilhar
Informação da revista

Estatísticas

Siga este link para acessar o texto completo do artigo

Case report
Fulminant myocarditis associated with pandemic H1N1 influenza A virus
Miocardite fulminante associada ao vírus influenza A pandémico H1N1
Marta Cabrala,
Autor para correspondência
mssr.cabral@gmail.com

Corresponding author.
, Maria J. Britoa, Marta Condea, Mário Oliveirab, Gonçalo C. Ferreiraa
a Department of Pediatrics, Hospital Dona Estefânia – CHLC – EPE, Lisbon, Portugal
b Department of Pathology, Hospital de São José – CHLC – EPE, Lisbon, Portugal
Lido
11725
Vezes
que se leu este artigo
2582
Total PDF
9143
Total HTML
Compartilhar estatísticas
 array:24 [
  "pii" => "S0870255112001138"
  "issn" => "08702551"
  "doi" => "10.1016/j.repc.2011.11.012"
  "estado" => "S300"
  "fechaPublicacion" => "2012-07-01"
  "aid" => "119"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "sco"
  "cita" => "Rev Port Cardiol. 2012;31:517-20"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 7705
    "formatos" => array:3 [
      "EPUB" => 195
      "HTML" => 6240
      "PDF" => 1270
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S087025511200128X"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2012.05.006"
    "estado" => "S300"
    "fechaPublicacion" => "2012-07-01"
    "aid" => "122"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Rev Port Cardiol. 2012;31:521-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6023
      "formatos" => array:3 [
        "EPUB" => 195
        "HTML" => 4458
        "PDF" => 1370
      ]
    ]
    "pt" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Caso Cl&#237;nico</span>"
      "titulo" => "Assist&#234;ncia ventricular esquerda numa crian&#231;a de 5 anos &#8211; ponte para recupera&#231;&#227;o num caso de miocardite viral"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => "pt"
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "521"
          "paginaFinal" => "524"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Left ventricular assist device in a five-year-old child&#58; A bridge to recovery in a case of viral myocarditis"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1069
              "Ancho" => 1257
              "Tamanyo" => 100031
            ]
          ]
          "descripcion" => array:1 [
            "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Melhoria gradual da fun&#231;&#227;o card&#237;aca e diminui&#231;&#227;o da dilata&#231;&#227;o do ventr&#237;culo esquerdo ap&#243;s in&#237;cio de assist&#234;ncia ventricular&#46; As setas pretas indicam&#44; da esquerda para a direita&#44; implanta&#231;&#227;o e retirada da assist&#234;ncia ventricular externa&#46; AVE&#58; assist&#234;ncia ventricular externa&#59; FEVE&#58; fra&#231;&#227;o de eje&#231;&#227;o&#59; FencVE&#58; fra&#231;&#227;o de encurtamento&#59; VEd&#58; di&#226;metro do ventr&#237;culo esquerdo em di&#225;stole&#59; VTI&#58; integral velocidade tempo na c&#226;mara de sa&#237;da do ventr&#237;culo esquerdo&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Margarida Silva, Nuno Carvalho, Gra&#231;a Nogueira, Patr&#237;cia Costa, Rui Rodrigues, Miguel Abecasis, Manuela Nunes, Rui Anjos, Jos&#233; Neves"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "Margarida"
              "apellidos" => "Silva"
            ]
            1 => array:2 [
              "nombre" => "Nuno"
              "apellidos" => "Carvalho"
            ]
            2 => array:2 [
              "nombre" => "Gra&#231;a"
              "apellidos" => "Nogueira"
            ]
            3 => array:2 [
              "nombre" => "Patr&#237;cia"
              "apellidos" => "Costa"
            ]
            4 => array:2 [
              "nombre" => "Rui"
              "apellidos" => "Rodrigues"
            ]
            5 => array:2 [
              "nombre" => "Miguel"
              "apellidos" => "Abecasis"
            ]
            6 => array:2 [
              "nombre" => "Manuela"
              "apellidos" => "Nunes"
            ]
            7 => array:2 [
              "nombre" => "Rui"
              "apellidos" => "Anjos"
            ]
            8 => array:2 [
              "nombre" => "Jos&#233;"
              "apellidos" => "Neves"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087025511200128X?idApp=UINPBA00004E"
    "url" => "/08702551/0000003100000078/v1_201308021259/S087025511200128X/v1_201308021259/pt/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0870255112001126"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2011.11.011"
    "estado" => "S300"
    "fechaPublicacion" => "2012-07-01"
    "aid" => "118"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Rev Port Cardiol. 2012;31:513-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6650
      "formatos" => array:3 [
        "EPUB" => 201
        "HTML" => 5203
        "PDF" => 1246
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Cardiac thrombus and conduction disorder in takotsubo cardiomyopathy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "513"
          "paginaFinal" => "516"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Miocardiopatia de takotsubo complicada com trombo apical e altera&#231;&#245;es da condu&#231;&#227;o"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 978
              "Ancho" => 3000
              "Tamanyo" => 256630
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Results of cardiac catheterization&#46; Left ventriculography at end-systole &#40;A&#41; and end-diastole &#40;B&#41; demonstrating typical apical ballooning and double outline apex suggestive of apical thrombus&#46; Results of selective coronary angiography of the left main coronary artery &#40;C&#41; showing no significant stenosis&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ana Sofia Correia, Nuno Moreno, Alexandra Gon&#231;alves, V&#237;tor Ara&#250;jo, Teresa Pinho, Rui Andr&#233; Rodrigues, Filipe Macedo, Maria J&#250;lia Maciel"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Ana Sofia"
              "apellidos" => "Correia"
            ]
            1 => array:2 [
              "nombre" => "Nuno"
              "apellidos" => "Moreno"
            ]
            2 => array:2 [
              "nombre" => "Alexandra"
              "apellidos" => "Gon&#231;alves"
            ]
            3 => array:2 [
              "nombre" => "V&#237;tor"
              "apellidos" => "Ara&#250;jo"
            ]
            4 => array:2 [
              "nombre" => "Teresa"
              "apellidos" => "Pinho"
            ]
            5 => array:2 [
              "nombre" => "Rui Andr&#233;"
              "apellidos" => "Rodrigues"
            ]
            6 => array:2 [
              "nombre" => "Filipe"
              "apellidos" => "Macedo"
            ]
            7 => array:2 [
              "nombre" => "Maria J&#250;lia"
              "apellidos" => "Maciel"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255112001126?idApp=UINPBA00004E"
    "url" => "/08702551/0000003100000078/v1_201308021259/S0870255112001126/v1_201308021259/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
    "titulo" => "Fulminant myocarditis associated with pandemic H1N1 influenza A virus"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "517"
        "paginaFinal" => "520"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Marta Cabral, Maria J&#46; Brito, Marta Conde, M&#225;rio Oliveira, Gon&#231;alo C&#46; Ferreira"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Marta"
            "apellidos" => "Cabral"
            "email" => array:1 [
              0 => "mssr&#46;cabral&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Maria J&#46;"
            "apellidos" => "Brito"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Marta"
            "apellidos" => "Conde"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "M&#225;rio"
            "apellidos" => "Oliveira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Gon&#231;alo C&#46;"
            "apellidos" => "Ferreira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Department of Pediatrics&#44; Hospital Dona Estef&#226;nia &#8211; CHLC &#8211; EPE&#44; Lisbon&#44; Portugal"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Department of Pathology&#44; Hospital de S&#227;o Jos&#233; &#8211; CHLC &#8211; EPE&#44; Lisbon&#44; Portugal"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Miocardite fulminante associada ao v&#237;rus influenza A pand&#233;mico H1N1"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2354
            "Ancho" => 1584
            "Tamanyo" => 331795
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Intermediate &#40;A&#41; and high &#40;B&#41; magnification of myocardium with multifocal infiltrates composed mostly of lymphocytes but also some neutrophils&#44; macrophages&#44; plasma cells and eosinophils&#44; associated with myocyte necrosis and ischemia&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Acute myocarditis&#44; albeit rare and potentially lethal&#44; is a well-recognized manifestation of numerous viral infections with a broad spectrum of symptoms and clinical features&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The etiological agents of viral myocarditis include enteroviruses&#44; adenoviruses&#44; parvoviruses&#44; hepatitis C virus&#44; human immunodeficiency virus&#44; influenza&#44; and others&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Coxsackie B virus has been described as the most common pathogen of viral myocarditis and hepatitis C virus is associated with many different forms of heart disease worldwide&#59; however&#44; influenza myocarditis is relatively rare&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> Many people are affected by seasonal influenza every year&#44; but the myocarditogenicity of this virus seems to be fairly low&#46; The frequency of myocardial involvement in influenza infection is unclear&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> but some studies report that it ranges from 0 to 11&#37;&#44; depending on the diagnostic criteria used to define myocarditis&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Myocarditis is an inflammatory disorder characterized by myocyte necrosis and inflammatory infiltrate of the myocardium&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> The pathogenesis of influenza myocarditis is also unclear&#46; Host immune response may play a role&#44; as well as direct cytolysis by viral infection&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Fulminant myocarditis is an uncommon complication&#44; typically diagnosed in association with circulatory collapse or at autopsy in patients with influenza-associated fatal outcomes&#46; It may present with fatal arrhythmias&#44; atrioventricular block and&#47;or varying degrees of heart failure&#44; cardiogenic shock being the most severe&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A few case reports and series present incidental diagnoses of influenza-associated acute fulminant myocarditis&#44; but the true prevalence remains unknown&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> We present a case of rapidly fatal fulminant pandemic influenza A &#40;H1N1&#41; virus &#40;H1N1v&#41;-associated myocarditis&#44; with no previous cardiac symptomatology&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case report</span><p id="par0020" class="elsevierStylePara elsevierViewall">A previously healthy 10-year-old boy presented to the emergency department with a three-day history of a flu-like syndrome&#58; fever&#44; cough&#44; headache&#44; generalized myalgia&#44; vomiting and diarrhea&#46; He had no known risk factors for complications of influenza&#44; he was not previously vaccinated for seasonal or pandemic influenza viruses and he was not receiving any antiviral treatment&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">At admission&#44; he was pale and had signs of dehydration&#46; Body temperature was 34&#46;7<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; pulse rate 120<span class="elsevierStyleHsp" style=""></span>beats&#47;min and blood pressure 84&#47;65<span class="elsevierStyleHsp" style=""></span>mmHg &#40;median arterial pressure&#58; 65<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#46; Pulse oximetry showed oxygen saturation of 96&#8211;98&#37; and cardiac physical examination was normal&#46; Chest radiography revealed diffuse bilateral alveolar infiltrates&#46; Laboratory findings included 11<span class="elsevierStyleHsp" style=""></span>300<span class="elsevierStyleHsp" style=""></span>leukocytes&#47;mm<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> &#40;84&#46;5&#37; neutrophils&#41;&#44; C-reactive protein 2&#46;41<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; and elevated creatinine &#40;1&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#44; glucose &#40;217<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; and phosphorus &#40;8&#46;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#44; with no other abnormalities&#46; The patient&#39;s clinical condition improved significantly after intravenous fluid administration&#59; however&#44; when he was hemodynamically stable&#44; sudden asystolic cardiac arrest occurred&#46; Advanced life support was immediately started but was ineffective and the patient died&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Further investigation showed mild elevation of CK&#44; CK-MB and myoglobin&#46; Reverse transcriptase polymerase chain reaction assay from nasopharyngeal swab samples was positive for H1N1v&#46; The autopsy showed multifocal infiltrates composed mostly of lymphocytes but also some neutrophils&#44; macrophages&#44; plasma cells and eosinophils&#44; associated with myocyte necrosis and ischemia&#44; which was compatible with myocarditis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41; and excluded the diagnosis of hypertrophic cardiomyopathy&#46; The lung tissue specimen obtained at autopsy showed diffuse pulmonary vascular congestion and extensive alveolar hemorrhage &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46; Additionally&#44; multisystem histological changes including the cardiac and pulmonary alterations described above&#44; and tracheobronchial and intestinal involvement associated with viral infection were evident&#44; leading to a definite postmortem diagnosis of fulminant viral myocarditis&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">The prevalence of fulminant myocarditis associated with H1N1v is unknown because of the lack of comprehensive screening&#44; with only a handful of case reports and autopsy findings in the literature&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Bratincsak et al&#46; reported four fulminant myocarditis cases associated with H1N1v in children and suggested that the 2009 pandemic influenza virus was more commonly associated with myocarditis than seasonal influenza&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The Japanese pandemic influenza registry reported 15 patients with H1N1v-associated myocarditis&#44; ranging from a child to a man over 70 years old&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> According to a report from Canada&#44; only two of 505 children hospitalized with severe influenza infection had myocarditis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> There are few individual case reports of fulminant myocarditis from the USA and Europe&#44;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#8211;12</span></a> and a single fatal case was reported in a multicenter pediatric study conducted in Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> This is the first report in Portugal&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Common cardiac symptoms of myocarditis include dyspnea&#44; chest discomfort&#44; hypotension&#44; peripheral edema and syncope&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In the case of myocarditis caused by H1N1v&#44; clinical manifestations vary greatly&#46; Ukimura et al&#46; reported that cardiac dysfunction had progressed rapidly in 12 out of 15 patients&#44; and developed after recovery from flu-like symptoms in two patients&#46; Ten patients with fulminant myocarditis had fatal arrhythmias and&#47;or cardiogenic shock&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Cardiopulmonary arrest as the first cardiac symptom was described in only two patients&#44; as happened with our patient&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Small autopsy-based studies have shown complication rates of myocarditis in fatal cases of 39&#46;4&#37; with Asian flu and 48&#37; with Spanish flu&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> All these fatal cases with myocarditis had severe pneumonia and multiple organ involvement&#44; implying that myocarditis was likely to be a terminally ill state of influenza infection&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> as could have been the case with our patient&#44; according to the histopathological findings on autopsy &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figures 1 and 2</a>&#41;&#46; By contrast&#44; severe viral pneumonia did not precede myocarditis in the 15 cases reported by Ukimura et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Some patients complained only of high fever&#44; without respiratory symptoms before the onset of myocarditis&#46; The findings imply that the H1N1v may have a high affinity for heart tissue in some susceptible patients&#46; In this patient there was initially thought to be an underlying cardiac disease &#40;hypertrophic cardiomyopathy&#41;&#44; which could have increased his susceptibility to cardiac complications&#44; but this comorbidity was excluded by histopathology findings&#46; Despite the presence of tachycardia&#44; hypotension and hypothermia secondary to dehydration at admission&#44; the patient was hemodynamically stable immediately before asystolic cardiac arrest and death&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Data on the clinical benefits of antiviral treatment for H1N1v are limited and different authorities have different recommendations&#46; The Hong Kong Hospital Authority Central Committee on Infectious Disease and Emergency Responses &#40;CCIDER&#41; recommend that empirical antiviral treatment be started immediately in patients who are at higher risk for developing complications&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> including those younger than six years&#44; morbidly obese&#44; asthmatic&#44; immunocompromised or pregnant subjects&#44; patients showing no improvement in symptoms 48<span class="elsevierStyleHsp" style=""></span>h after medical treatment and in patients in whom H1N1v infection has been confirmed&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> There are compelling indications for the use of beta blockers and&#47;or angiotensin-converting enzyme inhibitors for the treatment of a subacute phase of the illness&#59; additional supportive intervention is essential as first-line therapy for myocarditis patients with heart failure&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The recent application of intra-aortic balloon pump and&#47;or veno-venous extracorporeal membrane oxygenation &#40;ECMO&#41; in serious cases has yielded good outcomes&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;16&#44;17</span></a> but in this case&#44; despite aggressive management&#44; circulatory resuscitation was not successful&#46; This patient did not receive antiviral treatment&#44; which has been convincingly shown to decrease morbidity and mortality in H1N1v infection&#46; However&#44; as this was a case of fulminant evolution&#44; with rapid progression of inflammatory infiltration&#44; antiviral treatment probably would not have had sufficient time to be effective&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Early detection of myocarditis in patients during influenza pandemics is difficult&#44; as there are no specific symptoms or signs&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> To avoid misdiagnosis it is essential to determine the characteristic symptoms&#44; signs and laboratory findings of acute myocarditis&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> but it is also important to remember that it can occur suddenly&#44; without any previous suspicious symptom or sign&#44; as was seen in our patient&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">This was the first death in the Portuguese pediatric population during the 2009 H1N1v pandemic&#44; and provided arguments for more stringent indications for antiviral therapy in the context of influenza pandemics&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusion</span><p id="par0070" class="elsevierStylePara elsevierViewall">The fulminant form of myocarditis associated with H1N1v may present in the form of fatal arrhythmia&#44; atrioventricular block and&#47;or cardiogenic shock&#44; usually diagnosed in the context of circulatory collapse or autopsy in patients with H1N1v infection&#44; as occurred in this patient&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">As the incidence of H1N1v infection continues to rise&#44; physicians should be aware of this rare and potentially fatal complication&#44; since early diagnosis and aggressive supportive measures are essential&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:2 [
          "identificador" => "xres250452"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec238020"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres250451"
          "titulo" => "Resumo"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec238019"
          "titulo" => "Palavras-chave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Case report"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Conclusion"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflict of interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2011-10-01"
    "fechaAceptado" => "2011-11-30"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec238020"
          "palabras" => array:4 [
            0 => "Influenza"
            1 => "H1N1"
            2 => "Fulminant"
            3 => "Myocarditis"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec238019"
          "palabras" => array:4 [
            0 => "Influenza"
            1 => "H1NI"
            2 => "Fulminante"
            3 => "Miocardite"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Fulminant myocarditis associated with influenza A virus is exceedingly rare&#44; with only a few cases reported in the literature&#46; We describe a previously healthy 10-year-old boy&#44; with a three-day history of flu-like symptoms without antiviral treatment&#46; He was hospitalized with dehydration and hypothermia in the context of persistent vomiting&#44; when he suddenly developed heart failure secondary to fulminant myocarditis&#46; Despite aggressive management&#44; including circulatory support and cardiopulmonary resuscitation measures&#44; the patient died of cardiogenic shock&#46; The postmortem histopathology was compatible with a multisystem viral infection with myocarditis and pulmonary involvement&#44; and H1N1v polymerase chain reaction was positive&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The prevalence of influenza-associated fulminant myocarditis remains unknown&#46; Findings reported in the literature raise the possibility that the novel H1N1 influenza A virus is more commonly associated with a severe form of myocarditis than previously encountered influenza strains&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A miocardite fulminante associada ao v&#237;rus Influenza A &#233; extremamente rara&#44; com apenas alguns casos relatados na literatura&#46; Descrevemos um rapaz de 10 anos&#44; previamente saud&#225;vel&#44; com hist&#243;ria de sintomas gripais com 3 dias de evolu&#231;&#227;o&#44; sem terap&#234;utica antiviral&#46; Foi internado por desidrata&#231;&#227;o e hipotermia&#44; no contexto de v&#243;mitos persistentes ap&#243;s o que&#44; subitamente&#44; desenvolveu insufici&#234;ncia card&#237;aca secund&#225;ria a miocardite fulminante&#46; Apesar da interven&#231;&#227;o imediata&#44; incluindo suporte circulat&#243;rio e reanima&#231;&#227;o cardiorrespirat&#243;ria&#44; o doente faleceu por choque cardiog&#233;nico&#46; O exame histopatol&#243;gico <span class="elsevierStyleItalic">post-mortem</span> foi compat&#237;vel com o diagn&#243;stico de infec&#231;&#227;o viral multissist&#233;mica&#44; com miocardite e envolvimento pulmonar e a PCR para o H1N1<span class="elsevierStyleHsp" style=""></span>v foi positiva&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A preval&#234;ncia de miocardite fulminante associada ao v&#237;rus Influenza permanece desconhecida&#46; Relatos na literatura levantam a hip&#243;tese de o v&#237;rus Influenza A H1N1 estar mais frequentemente associado a formas graves de miocardite do que as estirpes sazonais anteriores&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2379
            "Ancho" => 1584
            "Tamanyo" => 492974
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Low &#40;A&#41; and intermediate &#40;B&#41; magnification of pulmonary parenchyma with vascular congestion and multiple foci of alveolar hemorrhage&#44; without associated inflammation&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2354
            "Ancho" => 1584
            "Tamanyo" => 331795
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Intermediate &#40;A&#41; and high &#40;B&#41; magnification of myocardium with multifocal infiltrates composed mostly of lymphocytes but also some neutrophils&#44; macrophages&#44; plasma cells and eosinophils&#44; associated with myocyte necrosis and ischemia&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:17 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fulminant myocarditis associated with pandemic H1N1 influenza A virus in children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Bratincsak"
                            1 => "H&#46; El-said"
                            2 => "J&#46; Bradley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2010.01.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2010"
                        "volumen" => "55"
                        "paginaInicial" => "928"
                        "paginaFinal" => "929"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20153131"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical Research Committee on Myocarditis Associated with the 2009 Influenza A &#40;H1N1&#41; Pandemic in Japan organized by the Japanese Circulation Society&#46; A National Survey on Myocarditis Associated with the 2009 Influenza A &#40;H1N1&#41; Pandemic in Japan"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Ukimura"
                            1 => "T&#46; Izumi"
                            2 => "A&#46; Matsumori"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circ J"
                        "fecha" => "2010"
                        "volumen" => "74"
                        "paginaInicial" => "2193"
                        "paginaFinal" => "2199"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20697177"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Coxsackevirus myocarditis&#58; interplay between virus and host in the pathogenesis of heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Tam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/vim.2006.19.133"
                      "Revista" => array:6 [
                        "tituloSerie" => "Viral Immunol"
                        "fecha" => "2006"
                        "volumen" => "19"
                        "paginaInicial" => "133"
                        "paginaFinal" => "146"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16817756"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Global alert and response network for hepatitis C virus-derived heart diseases&#58; a call to action"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Matsumori"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "CVD Prevent Control"
                        "fecha" => "2009"
                        "volumen" => "4"
                        "paginaInicial" => "109"
                        "paginaFinal" => "118"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influenza myocarditis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Kodama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circ J"
                        "fecha" => "2010"
                        "volumen" => "74"
                        "paginaInicial" => "2060"
                        "paginaFinal" => "2061"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20838004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular manifestations associated with influenza virus infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Mamas"
                            1 => "D&#46; Fraser"
                            2 => "L&#46; Neyses"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijcard.2008.04.044"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cardiol"
                        "fecha" => "2008"
                        "volumen" => "130"
                        "paginaInicial" => "304"
                        "paginaFinal" => "309"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18625525"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of myocarditis mimicking acute coronary syndrome associated with H1N1 influenza A virus infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Sahin"
                            1 => "M&#46; Demir"
                            2 => "B&#46; Kurtaran"
                            3 => "A&#46; Usal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Turk Soc Cardiol"
                        "fecha" => "2010"
                        "volumen" => "38"
                        "paginaInicial" => "572"
                        "paginaFinal" => "575"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fulminant fatal swine influenza &#40;H1N1&#41;&#58; myocarditis&#44; myocardial infarction&#44; or severe influenza pneumonia&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46; Cunha"
                            1 => "U&#46; Syed"
                            2 => "N&#46; Mickail"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.hrtlng.2010.04.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Heart Lung"
                        "fecha" => "2010"
                        "volumen" => "39"
                        "paginaInicial" => "453"
                        "paginaFinal" => "458"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20831976"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fulminant myocarditis associated with novel H1N1 influenza A"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Khouzam"
                            1 => "C&#46; Parizianu"
                            2 => "A&#46; Hafiz"
                            3 => "S&#46; Chawla"
                            4 => "R&#46; Schwartz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Heart Lung"
                        "fecha" => "2011"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3882636"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Myocarditis in a juvenile patient with influenza A virus infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Weiss"
                            1 => "H&#46; Knut"
                            2 => "K&#46; Stensaeth"
                            3 => "J&#46; Eritsland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurheartj/ehp566"
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2010"
                        "volumen" => "31"
                        "paginaInicial" => "277"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20007610"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Myocarditis due to pandemic influenza A &#40;H1N1&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Penela"
                            1 => "A&#46; Regueiro-Cueva"
                            2 => "J&#46;T&#46; Ortiz-P&#233;rez"
                            3 => "M&#46; Sitges"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Cardiol"
                        "fecha" => "2010"
                        "volumen" => "63"
                        "paginaInicial" => "1386"
                        "paginaFinal" => "1387"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21070738"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fulminant myocarditis due to H1N1 influenza"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Al-Ammodi"
                            1 => "K&#46; Rao"
                            2 => "S&#46; Rao"
                            3 => "J&#46; Brewer"
                            4 => "A&#46; Maglski"
                            5 => "A&#46; Chhatriwalla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCHEARTFAILURE.109.884395"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circ Heart Fail"
                        "fecha" => "2010"
                        "volumen" => "3"
                        "paginaInicial" => "7"
                        "paginaFinal" => "9"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20009044"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Caracter&#237;sticas cl&#237;nicas de la gripe A H1N1 2009&#58; est&#250;dio multic&#233;ntrico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Muga"
                            1 => "N&#46; Monmany"
                            2 => "S&#46; Carretero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "An Pediatr"
                        "fecha" => "2011"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "HA Central Committee on Infectious Disease and Emergency Responses &#40;CCIDER&#41;&#46; Interim guideline on antiviral treatment&#44; chemoprophylaxis and pneumococcal vaccination for human swine influenza&#47;influenza A &#40;H1N1&#41; Infection&#46; 21 Oct 2009&#46; Available from&#58; <a class="elsevierStyleInterRef" href="http://www.ha.org.hk/haho/ho/hsflu/Interim_Treatment_091021.pdf">http&#58;&#47;&#47;www&#46;ha&#46;org&#46;hk&#47;haho&#47;ho&#47;hsflu&#47;Interim&#95;Treatment&#95;091021&#46;pdf</a>&#46;"
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Bartlett&#44; J&#46; H1N1 Influenza &#8211; just the facts&#58; clinical features and epidemiology&#46; 2009&#46; Available from&#58; <a class="elsevierStyleInterRef" href="http://www.medscape.com/viewarticle/709540">http&#58;&#47;&#47;www&#46;medscape&#46;com&#47;viewarticle&#47;709540</a>&#46;"
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A child with influenza A &#40;H1N1&#41;-associated myocarditis rescued by extracorporeal membrane oxygenation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46; Oda"
                            1 => "H&#46; Yasunaga"
                            2 => "Y&#46; Tsutsumi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10047-010-0523-y"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Artif Organs"
                        "fecha" => "2010"
                        "volumen" => "13"
                        "paginaInicial" => "232"
                        "paginaFinal" => "234"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21088859"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influenza myocarditis and myositis&#58; case presentation and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Kumar"
                            1 => "M&#46; Guirgis"
                            2 => "S&#46; Zieroth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cjca.2011.03.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Can J Cardiol"
                        "fecha" => "2011"
                        "volumen" => "27"
                        "paginaInicial" => "514"
                        "paginaFinal" => "522"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21652168"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/08702551/0000003100000078/v1_201308021259/S0870255112001138/v1_201308021259/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "362"
    "tipo" => "SECCION"
    "pt" => array:2 [
      "titulo" => "Casos cl&#237;nicos"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "pt"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08702551/0000003100000078/v1_201308021259/S0870255112001138/v1_201308021259/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255112001138?idApp=UINPBA00004E"
]
Informação do artigo
ISSN: 08702551
Idioma original: Inglês
Dados atualizados diariamente
Ano/Mês Html Pdf Total
2024 Novembro 8 5 13
2024 Outubro 40 33 73
2024 Setembro 55 22 77
2024 Agosto 44 22 66
2024 Julho 41 29 70
2024 Junho 35 30 65
2024 Maio 54 23 77
2024 Abril 41 30 71
2024 Maro 40 12 52
2024 Fevereiro 39 25 64
2024 Janeiro 42 26 68
2023 Dezembro 35 25 60
2023 Novembro 30 24 54
2023 Outubro 28 15 43
2023 Setembro 34 22 56
2023 Agosto 29 17 46
2023 Julho 39 6 45
2023 Junho 37 15 52
2023 Maio 40 28 68
2023 Abril 27 10 37
2023 Maro 34 24 58
2023 Fevereiro 28 23 51
2023 Janeiro 38 14 52
2022 Dezembro 43 23 66
2022 Novembro 50 25 75
2022 Outubro 39 24 63
2022 Setembro 33 24 57
2022 Agosto 43 30 73
2022 Julho 35 43 78
2022 Junho 28 24 52
2022 Maio 32 31 63
2022 Abril 47 30 77
2022 Maro 25 34 59
2022 Fevereiro 33 22 55
2022 Janeiro 48 17 65
2021 Dezembro 21 27 48
2021 Novembro 43 44 87
2021 Outubro 60 52 112
2021 Setembro 30 31 61
2021 Agosto 53 36 89
2021 Julho 40 25 65
2021 Junho 35 22 57
2021 Maio 38 36 74
2021 Abril 114 54 168
2021 Maro 94 28 122
2021 Fevereiro 71 17 88
2021 Janeiro 45 8 53
2020 Dezembro 39 11 50
2020 Novembro 64 18 82
2020 Outubro 44 12 56
2020 Setembro 67 11 78
2020 Agosto 52 11 63
2020 Julho 72 9 81
2020 Junho 47 6 53
2020 Maio 95 8 103
2020 Abril 125 12 137
2020 Maro 321 18 339
2020 Fevereiro 266 57 323
2020 Janeiro 135 7 142
2019 Dezembro 85 14 99
2019 Novembro 57 7 64
2019 Outubro 40 4 44
2019 Setembro 68 16 84
2019 Agosto 80 7 87
2019 Julho 65 9 74
2019 Junho 57 13 70
2019 Maio 69 9 78
2019 Abril 41 18 59
2019 Maro 69 9 78
2019 Fevereiro 78 7 85
2019 Janeiro 73 3 76
2018 Dezembro 103 12 115
2018 Novembro 90 7 97
2018 Outubro 167 23 190
2018 Setembro 39 11 50
2018 Agosto 27 15 42
2018 Julho 33 9 42
2018 Junho 38 4 42
2018 Maio 44 10 54
2018 Abril 31 7 38
2018 Maro 60 9 69
2018 Fevereiro 33 3 36
2018 Janeiro 32 5 37
2017 Dezembro 75 12 87
2017 Novembro 55 7 62
2017 Outubro 51 16 67
2017 Setembro 62 11 73
2017 Agosto 85 21 106
2017 Julho 71 12 83
2017 Junho 56 16 72
2017 Maio 67 11 78
2017 Abril 35 7 42
2017 Maro 45 4 49
2017 Fevereiro 49 10 59
2017 Janeiro 47 8 55
2016 Dezembro 49 15 64
2016 Novembro 48 12 60
2016 Outubro 40 13 53
2016 Setembro 33 14 47
2016 Agosto 35 20 55
2016 Julho 15 13 28
2016 Junho 32 12 44
2016 Maio 6 14 20
2016 Abril 88 4 92
2016 Maro 113 17 130
2016 Fevereiro 111 21 132
2016 Janeiro 91 11 102
2015 Dezembro 79 17 96
2015 Novembro 64 11 75
2015 Outubro 79 7 86
2015 Setembro 70 10 80
2015 Agosto 68 12 80
2015 Julho 62 7 69
2015 Junho 38 6 44
2015 Maio 61 8 69
2015 Abril 70 12 82
2015 Maro 69 5 74
2015 Fevereiro 90 13 103
2015 Janeiro 102 13 115
2014 Dezembro 63 10 73
2014 Novembro 62 11 73
2014 Outubro 63 16 79
2014 Setembro 68 13 81
2014 Agosto 64 13 77
2014 Julho 55 17 72
2014 Junho 51 8 59
2014 Maio 92 6 98
2014 Abril 88 10 98
2014 Maro 94 18 112
2014 Fevereiro 120 19 139
2014 Janeiro 164 19 183
2013 Dezembro 85 15 100
2013 Novembro 67 16 83
2013 Outubro 54 11 65
2013 Setembro 61 28 89
2013 Agosto 86 16 102
2013 Julho 90 26 116
2013 Junho 68 18 86
2013 Maio 77 28 105
2013 Abril 95 41 136
2013 Maro 83 45 128
2013 Fevereiro 75 33 108
2013 Janeiro 74 40 114
2012 Dezembro 63 21 84
2012 Novembro 49 35 84
2012 Outubro 43 16 59
2012 Setembro 51 13 64
2012 Janeiro 83 0 83
Mostrar tudo

Siga este link para acessar o texto completo do artigo

Idiomas
Revista Portuguesa de Cardiologia
en pt

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

Ao assinalar que é «Profissional de Saúde», declara conhecer e aceitar que a responsável pelo tratamento dos dados pessoais dos utilizadores da página de internet da Revista Portuguesa de Cardiologia (RPC), é esta entidade, com sede no Campo Grande, n.º 28, 13.º, 1700-093 Lisboa, com os telefones 217 970 685 e 217 817 630, fax 217 931 095 e com o endereço de correio eletrónico revista@spc.pt. Declaro para todos os fins, que assumo inteira responsabilidade pela veracidade e exatidão da afirmação aqui fornecida.