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        "titulo" => "Necessidade a curto e a longo prazo de implanta&#231;&#227;o de <span class="elsevierStyleItalic">pacemaker</span> permanente ap&#243;s implanta&#231;&#227;o percut&#226;nea da v&#225;lvula prost&#233;tica a&#243;rtica <span class="elsevierStyleItalic">Edwards-Sapiens</span>"
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          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Receiver operating characteristic curves of baseline plasma creatinine value for predicting need for pacemaker implantation during the entire follow-up &#40;A&#41; and during hospitalization or in the first month after transcatheter aortic valve implantation &#40;B&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The need for pacemaker &#40;PM&#41; secondary to severe atrioventricular &#40;AV&#41; conduction abnormalities is a relatively common complication after transcatheter aortic valve implantation &#40;TAVI&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">1&#8211;12</span></a> This is apparently due to mechanical compression of the conduction system by the device&#44; as the His bundle and left branch are anatomically very close to the aortic annulus and aortic valve&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">13&#44;14</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The need for PM implantation after TAVI is especially frequent with the self-expanding CoreValve &#40;CV&#41; prosthesis &#40;Medtronic Inc&#46;&#44; Minneapolis&#44; MN&#41;&#44; and therefore information about this complication is mainly available on patients treated with this device&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">1&#44;2&#44;5&#8211;11</span></a> By contrast&#44; there are fewer data on the need for PM with the balloon-expandable Edwards Sapien &#40;ES&#41; valve &#40;Edwards Lifesciences Inc&#46;&#44; Irvine&#44; CA&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">12&#44;15</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Furthermore&#44; data on the need for PM implantation after TAVI are mainly related to the periprocedural period&#44; whereas there is less information on longer follow-up&#46; This is important&#44; because patients referred for TAVI are frequently of advanced age&#44; and may require PM implantation unrelated to TAVI&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The objective of this study was to evaluate the need for PM implantation&#44; as well as related factors&#44; both short- and long-term&#44; after ES device implantation&#46; For this purpose&#44; we performed a long-term follow-up of the first 100 patients treated with the ES at our institution&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Study population</span><p id="par0025" class="elsevierStylePara elsevierViewall">The first 100 patients treated with the ES at our institution were included in the study&#46; In all cases&#44; the indication was established by the heart team&#44; with the participation of clinical cardiologists&#44; interventional cardiologists and cardiac surgeons&#46; Briefly&#44; patients had symptomatic severe aortic stenosis &#40;valve area &#60;1 cm<span class="elsevierStyleSup">2</span>&#41; with high surgical risk and an estimated survival &#62;1 year&#46; Initially&#44; a EuroSCORE &#62;20&#37; was required&#44; but subsequently patients with EuroSCORE &#60;20&#37; and with other situations &#40;e&#46;g&#46;&#44; patent left internal mammary artery grafts and porcelain aorta were accepted&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Of the 100 patients&#44; 78 underwent TAVI by transfemoral access and 22 by transapical access&#46; The transfemoral approach was the first choice&#44; but transapical TAVI was performed when the iliac anatomy did not allow a safe procedure by a transfemoral approach&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Technique</span><p id="par0035" class="elsevierStylePara elsevierViewall">In all cases&#44; the procedure was performed under three-dimensional transesophageal monitoring and general anesthesia&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">A femoral vein was punctured to advance a temporary pacemaker into the right ventricle&#44; and a femoral artery was used to advance a pigtail catheter into the ascending aorta for angiographic monitoring of the procedure&#46; After the aortic valve was crossed with the guidewire&#44; balloon valvuloplasty under rapid pacing was performed in most cases&#46; The prosthetic valve was also implanted under rapid pacing &#40;180&#8211;220 bpm&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The temporary pacemaker was withdrawn 24 hours after the procedure in the absence of conduction abnormalities&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Statistical analysis</span><p id="par0050" class="elsevierStylePara elsevierViewall">The statistical analysis was performed using SPSS &#40;SPSS Inc&#46;&#44; Chicago&#44; IL&#41;&#46; Continuous variables were expressed as mean &#177; standard deviation&#44; and compared with the Student&#39;s t test&#46; Discrete variables were expressed as percentages &#40;proportions&#41;&#44; and compared with the chi-square test &#40;with Fisher&#39;s correction when necessary&#41;&#46; Associations were considered statistically significant with p&#60;0&#46;05&#46; The incidence of PM implantation was estimated with Kaplan-Meier survival analysis&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Rate of pacemaker implantation</span><p id="par0055" class="elsevierStylePara elsevierViewall">A new permanent PM was indicated before hospital discharge in eight patients&#46; The PM was implanted between 48 and 72 hours in six cases&#44; and in 3&#8211;5 days in two&#46; However&#44; 12 out of the 100 patients had a permanent PM before TAVI&#46; Thus&#44; the rate of new PM implantation was 9&#46;1&#37; &#40;eight of 88 patients without previous PM&#41;&#46; The indication for PM was atrial fibrillation with heart rate &#60;50 bpm in four patients&#44; sinus rhythm with complete AV block in three&#44; and sinus rhythm with high-degree AV block in one&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">After discharge&#44; another four patients required a permanent PM&#44; at 42 days&#44; three months&#44; 18 months&#44; and 30 months&#46; The cumulative rate of PM implantation was 9&#46;1&#177;0&#46;3&#37;&#44; 12&#46;1&#177;3&#46;6&#37;&#44; 12&#46;1&#177;3&#46;6&#37;&#44; 15&#46;8&#177;5&#46;0&#37; and 24&#46;2&#177;9&#46;2&#37; at 30 days&#44; six months&#44; one year&#44; two years and three years&#44; respectively &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Characteristics associated with the need for pacemaker implantation</span><p id="par0065" class="elsevierStylePara elsevierViewall">Important variables such as age&#44; aortic annulus diameter&#44; prosthetic valve diameter&#44; syncope previous to the procedure&#44; and left ventricular ejection fraction were not associated with the need for a new PM during the first 30 days or during follow-up &#40;<a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1&#8211;3</a>&#41;&#46; Interestingly&#44; some parameters of renal function were associated with the need for PM implantation in both the short and long term&#46; The presence of right bundle branch block was associated with the need for PM during the first month after TAVI&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="tbl0035"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Previous dialysis and right bundle branch block at baseline showed a statistically significant association with need for PM using the chi-square test &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; However&#44; after performing Fisher&#39;s correction&#44; only right bundle branch block showed a tendency for a greater need for PM&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The presence of right bundle branch block at baseline was not significantly related to the need for PM more than one month after TAVI &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 2</a>&#41;&#46; Nevertheless&#44; creatinine plasma level before the procedure was associated with the need for new PM beyond the first month&#58; 2&#46;5&#177;1&#46;7 mg&#47;dl and 1&#46;3&#177;0&#46;6 mg&#47;dl in patients with and without need for PM&#44; respectively &#40;p&#61;0&#46;001&#41;&#46; On the other hand&#44; a history of previous myocardial infarction was statistically associated with the need for late PM&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Considering both the first month after TAVI and long-term follow-up&#44; there were only two characteristics associated with the need for a new PM&#58; plasma creatinine at baseline and dialysis previous to TAVI &#40;<a class="elsevierStyleCrossRef" href="#tbl0035">Table 3</a>&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Receiver operating characteristic &#40;ROC&#41; curves for plasma creatinine showed an area under the curve &#40;AUC&#41; for need for PM during hospitalization of 0&#46;706 &#40;95&#37; confidence interval &#91;CI&#93;&#58; 0&#46;500&#8211;0&#46;912&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>A&#41;&#46; The ROC curve showed an AUC for need for PM throughout follow-up of 0&#46;777 &#40;95&#37; CI&#58; 0&#46;624&#8211;0&#46;930&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>B&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Discussion</span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Need for pacemaker after transcatheter aortic valve implantation</span><p id="par0090" class="elsevierStylePara elsevierViewall">Some patients undergoing TAVI need a permanent PM because of severe AV conduction disturbances&#44;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">1&#8211;12&#44;15</span></a> which appear to be related to device-induced trauma of the interventricular septum &#40;IVS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">14</span></a> During and after TAVI&#44; new left bundle branch block is relatively frequent&#44; secondary to conduction system damage during the procedure&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">16</span></a> As a result&#44; patients with conduction abnormalities before the procedure are at higher risk of needing a permanent PM after TAVI&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Although the rate is 2&#46;5&#8211;5 times lower with the ES than with the CV&#44;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">2&#44;5&#44;9</span></a> 4&#8211;11&#37; of patients treated with the ES need a permanent PM&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">1&#8211;12</span></a> With both systems&#44; this complication is more common than with surgical aortic valve replacement&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">17</span></a> In our series&#44; 9&#46;1&#37; of patients treated with the ES needed a permanent PM during initial hospitalization&#44; which is similar to the 8&#46;8&#37; incidence in the PARTNER trial and other studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">1&#8211;3&#44;12&#44;15</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Beyond the first month after TAVI&#44; some patients also needed PM implantation&#44; but probably in these cases it was not directly due to the valve procedure&#46; The need for PM beyond the first month after TAVI is probably related to the type of patients that are candidates for TAVI &#40;advanced age&#44; and high prevalence of renal failure&#41;&#44; irrespective of the valve intervention&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The need for PM after TAVI is not associated with higher mortality after the procedure&#44;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#44;9</span></a> but this complication prolongs hospital stay and can lead to complications such as pneumothorax&#44; bleeding and infections&#46; Moreover&#44; PM rhythm may be associated with impaired ventricular function<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">18</span></a> and a higher incidence of cardiac failure and cerebrovascular events during follow-up&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">19&#44;20</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Most of the conduction abnormalities associated with TAVI develop during the procedure &#40;sometimes even before valve implantation&#41;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">21</span></a> or soon after&#44; but may also occur beyond the first 48 hours&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">22</span></a> These conduction disturbances are usually persistent&#44; but some studies have shown that a significant proportion of patients undergoing permanent PM implantation after TAVI were not PM-dependent months after the procedure&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">8&#44;11&#44;7</span></a> This could justify more restrictive indications for permanent PM after TAVI&#44; precluding unnecessary PM implantation by delaying the decision in some patients&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">23</span></a> However&#44; our opinion is rather not to delay the indication for PM&#44; because in most cases conduction abnormalities after TAVI are irreversible&#44; and prolonged temporary transvenous pacing may also be associated with complications&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">24</span></a> Moreover&#44; in some studies of patients treated with TAVI&#44; those discharged with a permanent PM had a lower risk of sudden death after discharge&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">3</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Characteristics associated with the need for permanent pacemaker</span><p id="par0115" class="elsevierStylePara elsevierViewall">As the risk of permanent PM after TAVI is higher with the CV system&#44;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">2&#44;5&#44;9</span></a> a number of characteristics have been identified associating this complication with the use of this device<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">1&#44;2&#44;4&#44;6&#44;9&#44;15&#44;25&#44;26</span></a>&#58; depth of implantation&#44; use of first-generation devices&#44; IVS thickness&#44; left ventricular end-diastolic diameter&#44; conduction abnormalities before the procedure&#44; valve oversizing&#44; age over 75&#44; heart rate below 65 bpm before the procedure&#44; atrial fibrillation&#44; porcelain aorta&#44; balloon pre-dilatation&#44; and non-coronary cusp thickness&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">In our series of patients treated with the ES&#44; we found that both right bundle branch block and terminal chronic renal failure &#40;on dialysis&#41; were associated with the need for early permanent PM &#40;during hospitalization or during the first month&#41;&#46; Other variables&#44; such as access route &#40;transfemoral or transapical&#41;&#44; age&#44; valve diameter&#44; aortic annulus diameter&#44; or body mass index&#44; were not associated with this complication&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Right bundle branch block has been associated with higher frequency of PM implantation in several series of TAVI with the CV&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">4&#44;10&#44;27&#44;28</span></a> The AV node and left bundle branch are located near the aortic root and native aortic valve&#44;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">13</span></a> while the non-coronary cusp is adjacent to the membranous portion of the IVS&#44; which extends into a triangle bounded by the non-coronary and the right coronary cusps&#44; where the His bundle is located&#46; The left branch emerges in the membranous septum&#44; crosses the fibrous trigone and passes along the left surface of the muscular septum&#46; This is why previous right bundle branch block increases the risk of complete AV block if there is damage to the left ventricular outflow tract during TAVI&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The association between renal function and the need for PM after TAVI is less well understood&#46; Renal failure is associated with electrolyte abnormalities that can induce rhythm and conduction disturbances&#46; Most importantly&#44; chronic renal failure is associated with deposition of extracellular matrix and collagen and development of fibrosis in the myocardium that may result in conduction abnormalities&#44; arrhythmias and systolic and diastolic dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">29</span></a> More severe renal dysfunction is associated with a higher prevalence of left bundle branch block and advanced AV block&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">30</span></a> Renal failure is also a predictor of progression to complete AV block in patients with bifascicular block&#44;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">31</span></a> which is consistent with the greater need for permanent PM in longer-term follow-up that we observed late after TAVI&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Finally&#44; in our study previous infarction was associated with the need for permanent PM more than one month after TAVI&#46; Myocardial dysfunction occurring late after myocardial infarction may induce conduction abnormalities&#46; Previous myocardial infarction was not&#44; however&#44; associated with the need for PM during the first month after TAVI&#46;</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conclusions</span><p id="par0140" class="elsevierStylePara elsevierViewall">Most data on the need for PM implantation after TAVI have been obtained with the self-expanding CV device&#46; In our study&#44; performed with the balloon-expandable ES prosthetic valve&#44; 9&#46;1&#37; of patients needed a permanent PM during initial hospitalization or the first month after the procedure&#46; Right bundle branch block and renal function were associated with the need for PM after TAVI&#46; On the other hand&#44; patients treated with TAVI are at high risk of needing PM in the long term&#44; probably not directly due to TAVI&#44; but probably due to the characteristics of this patient population&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Ethical disclosures</span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Protection of human and animal subjects</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Confidentiality of data</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Right to privacy and informed consent</span><p id="par0155" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Conflicts of interest</span><p id="par0160" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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            0 => "Pacemaker"
            1 => "Transcatheter aortic valve implantation"
            2 => "Long term"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec813629"
          "palabras" => array:3 [
            0 => "<span class="elsevierStyleItalic">Pacemaker</span>"
            1 => "Implanta&#231;&#227;o valvular a&#243;rtica percut&#226;nea"
            2 => "Longo prazo"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A permanent pacemaker is frequently needed after transcatheter aortic valve implantation&#44; but the available data are mainly on the CoreValve system&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To evaluate the need for new permanent pacemaker after implantation of the Edwards Sapien device&#44; as well as related factors&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We included the first 100 patients treated with the Edwards Sapien device at our institution&#46; Of these&#44; 12 had a permanent pacemaker before the procedure&#44; and thus our study population was the remaining 88 patients&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A permanent pacemaker was indicated in eight patients &#40;9&#46;1&#37;&#41; during hospitalization or at 30 days&#46; After discharge&#44; another four patients needed a pacemaker &#40;at 42 days and three&#44; 18&#44; and 30 months&#41;&#46; Two variables were associated with the need for pacemaker during hospitalization&#58; previous dialysis &#40;13&#37; vs&#46; 1&#37;&#44; p&#61;0&#46;042&#41; and complete right bundle branch block before the procedure &#40;25&#37; vs&#46; 5&#37;&#44; p&#61;0&#46;032&#41;&#46; More than one month after the procedure&#44; the characteristics associated with the need for pacemaker were plasma creatinine level &#40;2&#46;5&#177;1&#46;7 vs&#46; 1&#46;3&#177;0&#46;6 mg&#47;dl&#44; p&#61;0&#46;001&#41; and previous myocardial infarction &#40;50&#37; vs&#46; 10&#37;&#44; p&#61;0&#46;013&#41;&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusion</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The rate of pacemaker implantation with the Edwards Sapien device was 9&#46;1&#37;&#46; Right bundle branch block and dialysis were associated with this complication&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objective"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Methods"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Results"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "pt" => array:3 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introdu&#231;&#227;o</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A necessidade de um <span class="elsevierStyleItalic">pacemaker</span> permanente ap&#243;s implanta&#231;&#227;o percut&#226;nea da v&#225;lvula a&#243;rtica &#233; frequente&#44; embora os dados dispon&#237;veis estejam principalmente associados ao sistema <span class="elsevierStyleItalic">CoreValve</span>&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">O objetivo foi avaliar o &#237;ndice do novo <span class="elsevierStyleItalic">pacemaker</span> permanente&#44; bem como todos os fatores relacionados&#44; ap&#243;s a implanta&#231;&#227;o do dispositivo <span class="elsevierStyleItalic">Edwards-Sapiens</span>&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Inclu&#237;mos os primeiros 100 doentes tratados com o dispositivo <span class="elsevierStyleItalic">Edwards-Sapiens</span> no nosso hospital&#46; Destes&#44; 12 j&#225; tinham <span class="elsevierStyleItalic">pacemaker</span> permanente antes do procedimento&#44; pelo que a popula&#231;&#227;o do estudo corresponde aos restantes 88 doentes&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">O <span class="elsevierStyleItalic">pacemaker</span> permanente foi indicado em oito doentes &#40;9&#44;1&#37;&#41; durante o internamento ou a 30 dias&#46; Ap&#243;s a alta hospitalar&#44; outros quatro doentes necessitaram de colocar o <span class="elsevierStyleItalic">pacemaker</span> &#40;aos 42 dias e aos tr&#234;s&#44; 18 e 30 meses&#41;&#46; Duas vari&#225;veis foram relacionadas com a necessidade de coloca&#231;&#227;o de <span class="elsevierStyleItalic">pacemaker</span> durante o internamento&#58; di&#225;lise pr&#233;via &#40;13 <span class="elsevierStyleItalic">versus</span> 1&#37;&#44; p&#61;0&#44;042&#41; e bloqueio completo do ramo direito antes do procedimento &#40;25 <span class="elsevierStyleItalic">versus</span> 5&#37;&#44; p&#61;0&#44;032&#41;&#46; Mais do que um m&#234;s ap&#243;s o procedimento&#44; as caracter&#237;sticas&#44; que foram relacionadas com a necessidade de coloca&#231;&#227;o de <span class="elsevierStyleItalic">pacemaker</span>&#44; foram os n&#237;veis da creatinina plasm&#225;tica &#40;2&#44;5&#177;1&#44;7 <span class="elsevierStyleItalic">versus</span> 1&#44;3&#177;0&#44;6 mg&#47;dl&#44; p&#61;0&#44;001&#41; e enfarte do mioc&#225;rdio pr&#233;vio &#40;50 <span class="elsevierStyleItalic">versus</span> 10&#37;&#44; p&#61;0&#44;013&#41;&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclus&#227;o</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">A necessidade de coloca&#231;&#227;o de <span class="elsevierStyleItalic">pacemaker</span> ap&#243;s a implanta&#231;&#227;o do dispositivo de <span class="elsevierStyleItalic">Edwards-Sapiens</span> foi de 9&#44;1&#37;&#46; O bloqueio completo do ramo direito e a di&#225;lise foram associados a esta complica&#231;&#227;o&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Introdu&#231;&#227;o"
          ]
          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Objetivos"
          ]
          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "M&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Conclus&#227;o"
          ]
        ]
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 778
            "Ancho" => 947
            "Tamanyo" => 59707
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Kaplan-Meier curve of cumulative incidence of new permanent pacemaker implantation&#46; PM&#58; permanent pacemaker&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 878
            "Ancho" => 1844
            "Tamanyo" => 101626
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Receiver operating characteristic curves of baseline plasma creatinine value for predicting need for pacemaker implantation during the entire follow-up &#40;A&#41; and during hospitalization or in the first month after transcatheter aortic valve implantation &#40;B&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">CABG&#58; coronary artery bypass grafting&#59; LBBB&#58; left bundle branch block&#59; LVEF&#58; left ventricular ejection fraction&#59; PCI&#58; percutaneous coronary intervention&#59; PM&#58; pacemaker&#59; RBBB&#58; right bundle branch block&#46;</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">In the comparison of proportions&#44; p values for both chi-square test and Fisher&#39;s correction are provided&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">PM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No PM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82&#177;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82&#177;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;880&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Female gender &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;785&#47;1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Weight &#40;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">74&#177;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#177;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;369&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Height &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">158&#177;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">159&#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;778&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Body mass index &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#177;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&#177;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">284&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hypertension &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;147&#47;0&#46;345&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hypercholesterolemia &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;946&#47;1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Diabetes &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;444&#47;0&#46;705&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous infarction &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;288&#47;0&#46;589&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous ischemic heart disease &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;636&#47;0&#46;723&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous PCI &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;831&#47;1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous CABG &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;944&#47;0&#46;341&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous stroke &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;608&#47;1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous chronic lung disease &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;133&#47;0&#46;199&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Creatinine clearance &#40;ml&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#177;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48&#177;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;327&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Baseline plasma creatinine &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;7&#177;0&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;3&#177;0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous hemodialysis &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;042&#47;0&#46;175&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous bundle branch block &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;137&#47;0&#46;155&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous RBBB &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;032&#47;0&#46;091&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous LBBB &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;915&#47;1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous malignancy &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;577&#47;1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous atrial fibrillation &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;683&#47;0&#46;722&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Logistic EuroSCORE &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;331&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous syncope &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;782&#47;1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Transapical approach &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;366&#47;0&#46;398&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Valve prosthesis diameter &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&#46;9&#177;2&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&#46;3&#177;1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;367&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Aortic annulus diameter &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#46;6&#177;2&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&#46;9&#177;2&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;416&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Aortic valve area &#40;cm<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;66&#177;0&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;68&#177;0&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;789&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Peak transvalvular gradient &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77&#177;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">75&#177;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;856&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mean transvalvular gradient &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41&#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">46&#177;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;316&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">LVEF &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&#177;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&#177;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;358&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1372092.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Association between baseline clinical and echocardiographic characteristics and the need for permanent pacemaker implantation during hospitalization or in the first month after TAVI&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">CABG&#58; coronary artery bypass grafting&#59; LBBB&#58; left bundle branch block&#59; LVEF&#58; left ventricular ejection fraction&#59; PCI&#58; percutaneous coronary intervention&#59; PM&#58; pacemaker&#59; RBBB&#58; right bundle branch block&#46;</p><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">In the comparison of proportions&#44; p values for both chi-square test and Fisher&#39;s correction are provided&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">PM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No PM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80&#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82&#177;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;692&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Female gender &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;172&#47;0&#46;305&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Weight &#40;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&#177;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#177;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;889&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Height &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">159&#177;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">159&#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;900&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Body mass index &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&#177;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&#177;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;992&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hypertension &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;112&#47;0&#46;167&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hypercholesterolemia &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;328&#47;0&#46;617&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Diabetes &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;597&#47;1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous infarction &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;013&#47;0&#46;062&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous ischemic heart disease &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;224&#47;0&#46;326&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous PCI &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;492&#47;0&#46;603&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous CABG &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;100&#47;0&#46;135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous stroke &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;317&#47;1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous chronic lung disease &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;818&#47;1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Creatinine clearance &#40;ml&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">47&#177;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;285&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Baseline plasma creatinine &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;5&#177;1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;3&#177;0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous hemodialysis &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;002&#47;0&#46;089&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous bundle branch block &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;717&#47;0&#46;559&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous RBBB &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;580&#47;1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous LBBB &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;379&#47;0&#46;388&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous malignancy &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;015&#47;0&#46;132&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous atrial fibrillation &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;452&#47;0&#46;631&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Logistic EuroSCORE &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#177;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;777&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous syncope &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;611&#47;0&#46;507&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Transapical approach &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;978&#47;1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Valve prosthesis diameter &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&#46;0&#177;1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&#46;3&#177;1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;508&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Aortic annulus diameter &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#46;6&#177;1&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#46;0&#177;2&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;622&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Aortic valve area &#40;cm<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;76&#177;0&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;67&#177;0&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;424&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Peak transvalvular gradient &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81&#177;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">75&#177;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;585&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mean transvalvular gradient &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45&#177;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44&#177;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;929&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">LVEF &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56&#177;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&#177;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;901&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1372093.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Association between baseline clinical and echocardiographic characteristics and the need for late &#40;&#62;1 month&#41; permanent pacemaker implantation&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl0035"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0130" class="elsevierStyleSimplePara elsevierViewall">CABG&#58; coronary artery bypass grafting&#59; LBBB&#58; left bundle branch block&#59; LVEF&#58; left ventricular ejection fraction&#59; PCI&#58; percutaneous coronary intervention&#59; PM&#58; pacemaker&#59; RBBB&#58; right bundle branch block&#46;</p><p id="spar0135" class="elsevierStyleSimplePara elsevierViewall">In the comparison of proportions&#44; p values for both chi-square test and Fisher&#39;s correction are provided&#46;</p><p id="spar0170" class="elsevierStyleSimplePara elsevierViewall">Underlined value refers to branch block either RBBB or LBBB&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">PM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No PM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81&#177;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82&#177;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;909&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Female gender &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;548&#47;0&#46;549&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Weight &#40;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#177;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">69&#177;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;391&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Height &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">158&#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">159&#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;860&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Body mass index &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#177;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&#177;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;349&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hypertension &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;802&#47;1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hypercholesterolemia &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;591&#47;0&#46;758&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Diabetes &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;336&#47;0&#46;523&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous infarction &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;533&#47;0&#46;621&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous ischemic heart disease &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;734&#47;0&#46;764&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous PCI &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;551&#47;0&#46;534&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous CABG &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;291&#47;0&#46;341&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous stroke &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;300&#47;0&#46;448&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous chronic lung disease &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;263&#47;0&#46;446&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Creatinine clearance &#40;ml&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#177;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48&#177;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;148&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Baseline plasma creatinine &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;0&#177;1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;2&#177;0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous hemodialysis &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;001&#47;0&#46;017&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleUnderline">34</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;143&#47;0&#46;219&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous RBBB &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;145&#47;0&#46;188&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous LBBB &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;533&#47;0&#46;621&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous malignancy &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;312&#47;0&#46;359&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous atrial fibrillation &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;909&#47;1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Logistic EuroSCORE &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&#177;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;491&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous syncope &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;938&#47;1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Transapical approach &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;438&#47;0&#46;476&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Valve prosthesis diameter &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&#46;9&#177;2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&#46;3&#177;1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;249&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Aortic annulus diameter &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#177;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#177;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;326&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Aortic valve area &#40;cm<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;70&#177;0&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;67&#177;0&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;754&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Peak transvalvular gradient &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">78&#177;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">75&#177;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;628&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mean transvalvular gradient &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#177;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45&#177;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;610&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">LVEF &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#177;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&#177;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;398&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">Association between baseline clinical and echocardiographic characteristics and the need for early or late permanent pacemaker implantation&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:31 [
            0 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "German Transcatheter Aortic Valve Interventions Registry I&#46; Incidence and predictors of permanent pacemaker implantation following transcatheter aortic valve implantation&#58; analysis from the German Transcatheter Aortic Valve Interventions Registry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Ledwoch"
                            1 => "J&#46; Franke"
                            2 => "U&#46; Gerckens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ccd.24915"
                      "Revista" => array:6 [
                        "tituloSerie" => "Catheter Cardiovasc Interv"
                        "fecha" => "2013"
                        "volumen" => "82"
                        "paginaInicial" => "E569"
                        "paginaFinal" => "E577"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23475694"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors of permanent pacemaker implantation in patients with severe aortic stenosis undergoing TAVR&#58; a meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46;C&#46; Siontis"
                            1 => "P&#46; J&#252;ni"
                            2 => "T&#46; Pilgrim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2014.04.033"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2014"
                        "volumen" => "64"
                        "paginaInicial" => "129"
                        "paginaFinal" => "140"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25011716"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Permanent pacemaker implantation after transcatheter aortic valve implantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Urena"
                            1 => "J&#46;G&#46; Webb"
                            2 => "C&#46; Tamburino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCULATIONAHA.113.005479"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2014"
                        "volumen" => "129"
                        "paginaInicial" => "1233"
                        "paginaFinal" => "1243"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24370552"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0175"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factors predicting and having an impact on the need for a permanent pacemaker after CoreValve prosthesis implantation using the new Accutrak delivery catheter system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;J&#46; Munoz-Garcia"
                            1 => "J&#46;M&#46; Hernandez"
                            2 => "M&#46;F&#46; Jimenez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jcin.2012.03.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "JACC Cardiovasc Interv"
                        "fecha" => "2012"
                        "volumen" => "5"
                        "paginaInicial" => "533"
                        "paginaFinal" => "539"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22625192"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adverse effects associated with transcatheter aortic valve implantation&#58; a meta-analysis of contemporary studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46;J&#46; Khatri"
                            1 => "J&#46;G&#46; Webb"
                            2 => "J&#46; Rodes-Cabau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7326/0003-4819-158-1-201301010-00007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "2013"
                        "volumen" => "158"
                        "paginaInicial" => "35"
                        "paginaFinal" => "46"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23277899"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0185"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Permanent pacemaker insertion after CoreValve transcatheter aortic valve implantation&#58; incidence and contributing factors &#40;the UK CoreValve Collaborative&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;Z&#46; Khawaja"
                            1 => "R&#46; Rajani"
                            2 => "A&#46; Cook"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCULATIONAHA.109.927152"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2011"
                        "volumen" => "123"
                        "paginaInicial" => "951"
                        "paginaFinal" => "960"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21339482"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0190"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors and course of high-degree atrioventricular block after transcatheter aortic valve implantation using the CoreValve Revalving System"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "V&#46; Guetta"
                            1 => "G&#46; Goldenberg"
                            2 => "A&#46; Segev"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2011.07.020"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2011"
                        "volumen" => "108"
                        "paginaInicial" => "1600"
                        "paginaFinal" => "1605"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21880290"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0195"
              "etiqueta" => "8"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pacemaker dependency after transcatheter aortic valve implantation with the self-expanding Medtronic CoreValve System"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;M&#46; Van der Boon"
                            1 => "N&#46;M&#46; Van Mieghem"
                            2 => "D&#46;A&#46; Theuns"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijcard.2012.11.115"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cardiol"
                        "fecha" => "2013"
                        "volumen" => "168"
                        "paginaInicial" => "1269"
                        "paginaFinal" => "1273"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23295037"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                      "titulo" => "Predictors of permanent pacemaker requirement after transcatheter aortic valve implantation&#58; insights from a Brazilian registry"
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                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;S&#46; Gensas"
                            1 => "A&#46; Caixeta"
                            2 => "D&#46; Siqueira"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijcard.2014.05.020"
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                        "tituloSerie" => "Int J Cardiol"
                        "fecha" => "2014"
                        "volumen" => "175"
                        "paginaInicial" => "248"
                        "paginaFinal" => "252"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24880480"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
                  "contribucion" => array:1 [
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                      "titulo" => "Incidence rate and predictors of permanent pacemaker implantation after transcatheter aortic valve implantation with self-expanding CoreValve prosthesis"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "V&#46; Calvi"
                            1 => "S&#46; Conti"
                            2 => "G&#46;P&#46; Pruiti"
                          ]
                        ]
                      ]
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                    0 => array:2 [
                      "doi" => "10.1007/s10840-011-9634-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Interv Card Electrophysiol"
                        "fecha" => "2012"
                        "volumen" => "34"
                        "paginaInicial" => "189"
                        "paginaFinal" => "195"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22119855"
                            "web" => "Medline"
                          ]
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                      ]
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                  ]
                ]
              ]
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              "identificador" => "bib0210"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pacemaker implantation after transcatheter aortic valve implantation"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Goldenberg"
                            1 => "J&#46; Kusniec"
                            2 => "E&#46; Kadmon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2013.07.022"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2013"
                        "volumen" => "112"
                        "paginaInicial" => "1632"
                        "paginaFinal" => "1634"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23998348"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0215"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frequency of conduction disturbances after transcatheter implantation of an Edwards Sapien aortic valve prosthesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Godin"
                            1 => "H&#46; Eltchaninoff"
                            2 => "A&#46; Furuta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2010.04.029"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2010"
                        "volumen" => "106"
                        "paginaInicial" => "707"
                        "paginaFinal" => "712"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20723650"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0220"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Visualizing anatomical evidences on atrioventricular conduction system for TAVR"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Kawashima"
                            1 => "F&#46; Sato"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijcard.2014.04.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cardiol"
                        "fecha" => "2014"
                        "volumen" => "174"
                        "paginaInicial" => "1"
                        "paginaFinal" => "6"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24750717"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Etiology of complete atrioventricular blockade after percutaneous aortic valve implantation&#46; Insights from necropsy study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Moreno"
                            1 => "D&#46; Dobarro"
                            2 => "L&#46; Calvo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2009"
                        "volumen" => "120"
                        "paginaInicial" => "29"
                        "paginaFinal" => "30"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors and clinical outcomes of permanent pacemaker implantation after transcatheter aortic valve replacement&#58; the PARTNER &#40;Placement of AoRtic TraNscathetER Valves&#41; trial and registry"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "PARTNER Publications Office"
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46;M&#46; Nazif"
                            1 => "J&#46;M&#46; Dizon"
                            2 => "R&#46;T&#46; Hahn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jcin.2014.07.022"
                      "Revista" => array:6 [
                        "tituloSerie" => "JACC Cardiovasc Interv"
                        "fecha" => "2015"
                        "volumen" => "8"
                        "paginaInicial" => "60"
                        "paginaFinal" => "69"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25616819"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0235"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of incidence and predictors of left bundle branch block after transcatheter aortic valve implantation using the CoreValve versus the Edwards valve"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "I&#46; Franzoni"
                            1 => "A&#46; Latib"
                            2 => "F&#46; Maisano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2013.04.026"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2013"
                        "volumen" => "112"
                        "paginaInicial" => "554"
                        "paginaFinal" => "559"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23726173"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Persistent annual permanent pacemaker implantation rate after surgical aortic valve replacement in patients with severe aortic stenosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "N&#46;M&#46; Van Mieghern"
                            1 => "S&#46;J&#46; Head"
                            2 => "W&#46; de Jong"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.athoracsur.2012.04.038"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "2012"
                        "volumen" => "94"
                        "paginaInicial" => "1143"
                        "paginaFinal" => "1149"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22698776"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hemodynamic impact and outcome of permanent pacemaker implantation following transcatheter aortic valve implantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Biner"
                            1 => "Y&#46; Michowitz"
                            2 => "E&#46; Leshem-Rubinow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2013.09.030"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2014"
                        "volumen" => "113"
                        "paginaInicial" => "132"
                        "paginaFinal" => "137"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24210334"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Heart failure and echocardiographic changes during long-term follow-up of patients with sick sinus syndrome randomized to single-chamber atrial or ventricular pacing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;C&#46; Nielsen"
                            1 => "H&#46;R&#46; Andersen"
                            2 => "P&#46;E&#46; Thomsen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1998"
                        "volumen" => "97"
                        "paginaInicial" => "987"
                        "paginaFinal" => "995"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9529267"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0255"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of permanent pacemaker implantation on clinical outcome among patients undergoing transcatheter aortic valve implantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46; Buellesfeld"
                            1 => "S&#46; Stortecky"
                            2 => "D&#46; Heg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2012.03.054"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2012"
                        "volumen" => "60"
                        "paginaInicial" => "493"
                        "paginaFinal" => "501"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22726632"
                            "web" => "Medline"
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                          "pii" => "S0147027214000026"
                          "estado" => "S300"
                          "issn" => "01470272"
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                  ]
                ]
              ]
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              "identificador" => "bib0260"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Timing and potential mechanisms of new conduction abnormalities during the implantation of the Medtronic CoreValve System in patients with aortic stenosis"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
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                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2011"
                        "volumen" => "32"
                        "paginaInicial" => "2067"
                        "paginaFinal" => "2074"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21622979"
                            "web" => "Medline"
                          ]
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                ]
              ]
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              "identificador" => "bib0265"
              "etiqueta" => "22"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence of late occurring bradyarrhythmias after TAVI with the self-expanding CoreValve aortic bioprosthesis"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
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                            2 => "S&#46;T&#46; Pleger"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00392-011-0398-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Res Cardiol"
                        "fecha" => "2012"
                        "volumen" => "101"
                        "paginaInicial" => "349"
                        "paginaFinal" => "355"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22179559"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0270"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety of a conservative strategy of permanent pacemaker implantation after transcatheter aortic CoreValve implantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; De Carlo"
                            1 => "C&#46; Giannini"
                            2 => "F&#46; Bedogni"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ahj.2011.12.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "2012"
                        "volumen" => "163"
                        "paginaInicial" => "492"
                        "paginaFinal" => "499"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22424022"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Causes of peri-operative mortality after transcatheter aortic valve implantation&#58; a pooled analysis of 12 studies and 1223 patients"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
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                            2 => "P&#46; Salinas"
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                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invasive Cardiol"
                        "fecha" => "2011"
                        "volumen" => "23"
                        "paginaInicial" => "180"
                        "paginaFinal" => "184"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21562344"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors for permanent pacemaker requirement after transcatheter aortic valve implantation with the CoreValve bioprosthesis"
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                          "etal" => true
                          "autores" => array:3 [
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                    ]
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                    0 => array:2 [
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                        "tituloSerie" => "Am Heart J"
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                        "volumen" => "157"
                        "paginaInicial" => "860"
                        "paginaFinal" => "866"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19376312"
                            "web" => "Medline"
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                ]
              ]
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              "identificador" => "bib0285"
              "etiqueta" => "26"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors of permanent pacemaker implantation after Medtronic CoreValve bioprosthesis implantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
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                    ]
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                  "host" => array:1 [
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                        "tituloSerie" => "Europace"
                        "fecha" => "2012"
                        "volumen" => "14"
                        "paginaInicial" => "1759"
                        "paginaFinal" => "1763"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22733983"
                            "web" => "Medline"
                          ]
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              ]
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              "identificador" => "bib0290"
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                0 => array:2 [
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                      "titulo" => "Electrocardiographic and imaging predictors for permanent pacemaker requirement after transcatheter aortic valve implantation"
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                  "host" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "J Heart Valve Dis"
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                        "volumen" => "20"
                        "paginaInicial" => "83"
                        "paginaFinal" => "90"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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Journal Information
Vol. 34. Issue 11.
Pages 665-672 (November 2015)
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Vol. 34. Issue 11.
Pages 665-672 (November 2015)
Original Article
Open Access
Short- and long-term need for permanent pacemaker after transcatheter implantation of the Edwards Sapien aortic valve prosthesis
Necessidade a curto e a longo prazo de implantação de pacemaker permanente após implantação percutânea da válvula prostética aórtica Edwards-Sapiens
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Raúl Morenoa,
Corresponding author
raulmorenog@hotmail.com

Corresponding author.
, Luis Calvoa, Angel Sánchez-Recaldea, Guillermo Galeotea, Santiago Jiménez-Valeroa, Teresa Lópeza, Ignacio Plazab, Rosa González-Daviac, Ulises Ramíreza, Jose Maria Mesaa, Isidro Moreno-Gomeza, José-Luis López-Sendóna
a Hospital Universitario La Paz, Madrid, Spain
b Hospital Infanta Cristina, Parla, Madrid, Spain
c Hospital Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain
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Tables (3)
Table 1. Association between baseline clinical and echocardiographic characteristics and the need for permanent pacemaker implantation during hospitalization or in the first month after TAVI.
Table 2. Association between baseline clinical and echocardiographic characteristics and the need for late (>1 month) permanent pacemaker implantation.
Table 3. Association between baseline clinical and echocardiographic characteristics and the need for early or late permanent pacemaker implantation.
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Abstract
Introduction

A permanent pacemaker is frequently needed after transcatheter aortic valve implantation, but the available data are mainly on the CoreValve system.

Objective

To evaluate the need for new permanent pacemaker after implantation of the Edwards Sapien device, as well as related factors.

Methods

We included the first 100 patients treated with the Edwards Sapien device at our institution. Of these, 12 had a permanent pacemaker before the procedure, and thus our study population was the remaining 88 patients.

Results

A permanent pacemaker was indicated in eight patients (9.1%) during hospitalization or at 30 days. After discharge, another four patients needed a pacemaker (at 42 days and three, 18, and 30 months). Two variables were associated with the need for pacemaker during hospitalization: previous dialysis (13% vs. 1%, p=0.042) and complete right bundle branch block before the procedure (25% vs. 5%, p=0.032). More than one month after the procedure, the characteristics associated with the need for pacemaker were plasma creatinine level (2.5±1.7 vs. 1.3±0.6 mg/dl, p=0.001) and previous myocardial infarction (50% vs. 10%, p=0.013).

Conclusion

The rate of pacemaker implantation with the Edwards Sapien device was 9.1%. Right bundle branch block and dialysis were associated with this complication.

Keywords:
Pacemaker
Transcatheter aortic valve implantation
Long term
Resumo
Introdução

A necessidade de um pacemaker permanente após implantação percutânea da válvula aórtica é frequente, embora os dados disponíveis estejam principalmente associados ao sistema CoreValve.

Objetivos

O objetivo foi avaliar o índice do novo pacemaker permanente, bem como todos os fatores relacionados, após a implantação do dispositivo Edwards-Sapiens.

Métodos

Incluímos os primeiros 100 doentes tratados com o dispositivo Edwards-Sapiens no nosso hospital. Destes, 12 já tinham pacemaker permanente antes do procedimento, pelo que a população do estudo corresponde aos restantes 88 doentes.

Resultados

O pacemaker permanente foi indicado em oito doentes (9,1%) durante o internamento ou a 30 dias. Após a alta hospitalar, outros quatro doentes necessitaram de colocar o pacemaker (aos 42 dias e aos três, 18 e 30 meses). Duas variáveis foram relacionadas com a necessidade de colocação de pacemaker durante o internamento: diálise prévia (13 versus 1%, p=0,042) e bloqueio completo do ramo direito antes do procedimento (25 versus 5%, p=0,032). Mais do que um mês após o procedimento, as características, que foram relacionadas com a necessidade de colocação de pacemaker, foram os níveis da creatinina plasmática (2,5±1,7 versus 1,3±0,6 mg/dl, p=0,001) e enfarte do miocárdio prévio (50 versus 10%, p=0,013).

Conclusão

A necessidade de colocação de pacemaker após a implantação do dispositivo de Edwards-Sapiens foi de 9,1%. O bloqueio completo do ramo direito e a diálise foram associados a esta complicação.

Palavras-chave:
Pacemaker
Implantação valvular aórtica percutânea
Longo prazo
Full Text
Introduction

The need for pacemaker (PM) secondary to severe atrioventricular (AV) conduction abnormalities is a relatively common complication after transcatheter aortic valve implantation (TAVI).1–12 This is apparently due to mechanical compression of the conduction system by the device, as the His bundle and left branch are anatomically very close to the aortic annulus and aortic valve.13,14

The need for PM implantation after TAVI is especially frequent with the self-expanding CoreValve (CV) prosthesis (Medtronic Inc., Minneapolis, MN), and therefore information about this complication is mainly available on patients treated with this device.1,2,5–11 By contrast, there are fewer data on the need for PM with the balloon-expandable Edwards Sapien (ES) valve (Edwards Lifesciences Inc., Irvine, CA).12,15

Furthermore, data on the need for PM implantation after TAVI are mainly related to the periprocedural period, whereas there is less information on longer follow-up. This is important, because patients referred for TAVI are frequently of advanced age, and may require PM implantation unrelated to TAVI.

The objective of this study was to evaluate the need for PM implantation, as well as related factors, both short- and long-term, after ES device implantation. For this purpose, we performed a long-term follow-up of the first 100 patients treated with the ES at our institution.

MethodsStudy population

The first 100 patients treated with the ES at our institution were included in the study. In all cases, the indication was established by the heart team, with the participation of clinical cardiologists, interventional cardiologists and cardiac surgeons. Briefly, patients had symptomatic severe aortic stenosis (valve area <1 cm2) with high surgical risk and an estimated survival >1 year. Initially, a EuroSCORE >20% was required, but subsequently patients with EuroSCORE <20% and with other situations (e.g., patent left internal mammary artery grafts and porcelain aorta were accepted).

Of the 100 patients, 78 underwent TAVI by transfemoral access and 22 by transapical access. The transfemoral approach was the first choice, but transapical TAVI was performed when the iliac anatomy did not allow a safe procedure by a transfemoral approach.

Technique

In all cases, the procedure was performed under three-dimensional transesophageal monitoring and general anesthesia.

A femoral vein was punctured to advance a temporary pacemaker into the right ventricle, and a femoral artery was used to advance a pigtail catheter into the ascending aorta for angiographic monitoring of the procedure. After the aortic valve was crossed with the guidewire, balloon valvuloplasty under rapid pacing was performed in most cases. The prosthetic valve was also implanted under rapid pacing (180–220 bpm).

The temporary pacemaker was withdrawn 24 hours after the procedure in the absence of conduction abnormalities.

Statistical analysis

The statistical analysis was performed using SPSS (SPSS Inc., Chicago, IL). Continuous variables were expressed as mean ± standard deviation, and compared with the Student's t test. Discrete variables were expressed as percentages (proportions), and compared with the chi-square test (with Fisher's correction when necessary). Associations were considered statistically significant with p<0.05. The incidence of PM implantation was estimated with Kaplan-Meier survival analysis.

ResultsRate of pacemaker implantation

A new permanent PM was indicated before hospital discharge in eight patients. The PM was implanted between 48 and 72 hours in six cases, and in 3–5 days in two. However, 12 out of the 100 patients had a permanent PM before TAVI. Thus, the rate of new PM implantation was 9.1% (eight of 88 patients without previous PM). The indication for PM was atrial fibrillation with heart rate <50 bpm in four patients, sinus rhythm with complete AV block in three, and sinus rhythm with high-degree AV block in one.

After discharge, another four patients required a permanent PM, at 42 days, three months, 18 months, and 30 months. The cumulative rate of PM implantation was 9.1±0.3%, 12.1±3.6%, 12.1±3.6%, 15.8±5.0% and 24.2±9.2% at 30 days, six months, one year, two years and three years, respectively (Figure 1).

Figure 1.

Kaplan-Meier curve of cumulative incidence of new permanent pacemaker implantation. PM: permanent pacemaker.

(0.06MB).
Characteristics associated with the need for pacemaker implantation

Important variables such as age, aortic annulus diameter, prosthetic valve diameter, syncope previous to the procedure, and left ventricular ejection fraction were not associated with the need for a new PM during the first 30 days or during follow-up (Tables 1–3). Interestingly, some parameters of renal function were associated with the need for PM implantation in both the short and long term. The presence of right bundle branch block was associated with the need for PM during the first month after TAVI.

Table 1.

Association between baseline clinical and echocardiographic characteristics and the need for permanent pacemaker implantation during hospitalization or in the first month after TAVI.

  PM  No PM 
Age (years)  82±4  82±7  0.880 
Female gender (%)  63  58  0.785/1.000 
Weight (kg)  74±14  70±13  0.369 
Height (cm)  158±8  159±9  0.778 
Body mass index (kg/m230±5  28±6  284 
Hypertension (%)  100  79  0.147/0.345 
Hypercholesterolemia (%)  50  51  0.946/1.000 
Diabetes (%)  25  39  0.444/0.705 
Previous infarction (%)  13  0.288/0.589 
Previous ischemic heart disease (%)  38  46  0.636/0.723 
Previous PCI (%)  38  34  0.831/1.000 
Previous CABG (%)  50  34  0.944/0.341 
Previous stroke (%)  13  20  0.608/1.000 
Previous chronic lung disease (%)  23  0.133/0.199 
Creatinine clearance (ml/min)  37±22  48±25  0.327 
Baseline plasma creatinine (mg/dl)  1.7±0.9  1.3±0.7  0.97 
Previous hemodialysis (%)  13  0.042/0.175 
Previous bundle branch block (%)  38  16  0.137/0.155 
Previous RBBB (%)  25  0.032/0.091 
Previous LBBB (%)  13  11  0.915/1.000 
Previous malignancy (%)  0.577/1.000 
Previous atrial fibrillation (%)  50  43  0.683/0.722 
Logistic EuroSCORE (%)  19±9  16±9  0.331 
Previous syncope (%)  13  16  0.782/1.000 
Transapical approach (%)  38  23  0.366/0.398 
Valve prosthesis diameter (mm)  24.9±2.2  24.3±1.7  0.367 
Aortic annulus diameter (mm)  21.6±2.5  20.9±2.1  0.416 
Aortic valve area (cm20.66±0.20  0.68±0.21  0.789 
Peak transvalvular gradient (mmHg)  77±13  75±23  0.856 
Mean transvalvular gradient (mmHg)  41±9  46±16  0.316 
LVEF (%)  53±16  57±11  0.358 

CABG: coronary artery bypass grafting; LBBB: left bundle branch block; LVEF: left ventricular ejection fraction; PCI: percutaneous coronary intervention; PM: pacemaker; RBBB: right bundle branch block.

In the comparison of proportions, p values for both chi-square test and Fisher's correction are provided.

Table 2.

Association between baseline clinical and echocardiographic characteristics and the need for late (>1 month) permanent pacemaker implantation.

  PM  No PM 
Age (years)  80±9  82±7  0.692 
Female gender (%)  25  60  0.172/0.305 
Weight (kg)  71±11  70±13  0.889 
Height (cm)  159±13  159±9  0.900 
Body mass index (kg/m228±2  28±6  0.992 
Hypertension (%)  50  82  0.112/0.167 
Hypercholesterolemia (%)  75  50  0.328/0.617 
Diabetes (%)  25  38  0.597/1.000 
Previous infarction (%)  50  10  0.013/0.062 
Previous ischemic heart disease (%)  75  44  0.224/0.326 
Previous PCI (%)  50  33  0.492/0.603 
Previous CABG (%)  75  35  0.100/0.135 
Previous stroke (%)  20  0.317/1.000 
Previous chronic lung disease (%)  25  20  0.818/1.000 
Creatinine clearance (ml/min)  32±9  47±25  0.285 
Baseline plasma creatinine (mg/dl)  2.5±1.7  1.3±0.6  0.001 
Previous hemodialysis (%)  25  0.002/0.089 
Previous bundle branch block (%)  25  18  0.717/0.559 
Previous RBBB (%)  0.580/1.000 
Previous LBBB (%)  25  11  0.379/0.388 
Previous malignancy (%)  25  0.015/0.132 
Previous atrial fibrillation (%)  25  44  0.452/0.631 
Logistic EuroSCORE (%)  15±7  17±9  0.777 
Previous syncope (%)  25  15  0.611/0.507 
Transapical approach (%)  25  24  0.978/1.000 
Valve prosthesis diameter (mm)  25.0±1.7  24.3±1.7  0.508 
Aortic annulus diameter (mm)  21.6±1.8  21.0±2.1  0.622 
Aortic valve area (cm20.76±0.09  0.67±0.21  0.424 
Peak transvalvular gradient (mmHg)  81±23  75±22  0.585 
Mean transvalvular gradient (mmHg)  45±15  44±15  0.929 
LVEF (%)  56±3  57±12  0.901 

CABG: coronary artery bypass grafting; LBBB: left bundle branch block; LVEF: left ventricular ejection fraction; PCI: percutaneous coronary intervention; PM: pacemaker; RBBB: right bundle branch block.

In the comparison of proportions, p values for both chi-square test and Fisher's correction are provided.

Table 3.

Association between baseline clinical and echocardiographic characteristics and the need for early or late permanent pacemaker implantation.

  PM  No PM 
Age (years)  81±6  82±7  0.909 
Female gender (%)  50  59  0.548/0.549 
Weight (kg)  73±13  69±13  0.391 
Height (cm)  158±9  159±9  0.860 
Body mass index (kg/m229±5  28±6  0.349 
Hypertension (%)  83  80  0.802/1.000 
Hypercholesterolemia (%)  58  50  0.591/0.758 
Diabetes (%)  25  40  0.336/0.523 
Previous infarction (%)  17  11  0.533/0.621 
Previous ischemic heart disease (%)  50  45  0.734/0.764 
Previous PCI (%)  42  33  0.551/0.534 
Previous CABG (%)  50  34  0.291/0.341 
Previous stroke (%)  21  0.300/0.448 
Previous chronic lung disease (%)  22  0.263/0.446 
Creatinine clearance (ml/min)  37±19  48±25  0.148 
Baseline plasma creatinine (mg/dl)  2.0±1.2  1.2±0.6  <0.001 
Previous hemodialysis (%)  17  <0.001/0.017 
Previous bundle branch block (%)  34  16  0.143/0.219 
Previous RBBB (%)  17  0.145/0.188 
Previous LBBB (%)  17  11  0.533/0.621 
Previous malignancy (%)  0.312/0.359 
Previous atrial fibrillation (%)  42  43  0.909/1.000 
Logistic EuroSCORE (%)  18±8  16±9  0.491 
Previous syncope (%)  17  16  0.938/1.000 
Transapical approach (%)  33  22  0.438/0.476 
Valve prosthesis diameter (mm)  24.9±2.0  24.3±1.7  0.249 
Aortic annulus diameter (mm)  22±2  21±2  0.326 
Aortic valve area (cm20.70±0.17  0.67±0.21  0.754 
Peak transvalvular gradient (mmHg)  78±16  75±23  0.628 
Mean transvalvular gradient (mmHg)  42±11  45±16  0.610 
LVEF (%)  54±13  57±11  0.398 

CABG: coronary artery bypass grafting; LBBB: left bundle branch block; LVEF: left ventricular ejection fraction; PCI: percutaneous coronary intervention; PM: pacemaker; RBBB: right bundle branch block.

In the comparison of proportions, p values for both chi-square test and Fisher's correction are provided.

Underlined value refers to branch block either RBBB or LBBB.

Previous dialysis and right bundle branch block at baseline showed a statistically significant association with need for PM using the chi-square test (Table 1). However, after performing Fisher's correction, only right bundle branch block showed a tendency for a greater need for PM.

The presence of right bundle branch block at baseline was not significantly related to the need for PM more than one month after TAVI (Table 2). Nevertheless, creatinine plasma level before the procedure was associated with the need for new PM beyond the first month: 2.5±1.7 mg/dl and 1.3±0.6 mg/dl in patients with and without need for PM, respectively (p=0.001). On the other hand, a history of previous myocardial infarction was statistically associated with the need for late PM.

Considering both the first month after TAVI and long-term follow-up, there were only two characteristics associated with the need for a new PM: plasma creatinine at baseline and dialysis previous to TAVI (Table 3).

Receiver operating characteristic (ROC) curves for plasma creatinine showed an area under the curve (AUC) for need for PM during hospitalization of 0.706 (95% confidence interval [CI]: 0.500–0.912) (Figure 2A). The ROC curve showed an AUC for need for PM throughout follow-up of 0.777 (95% CI: 0.624–0.930) (Figure 2B).

Figure 2.

Receiver operating characteristic curves of baseline plasma creatinine value for predicting need for pacemaker implantation during the entire follow-up (A) and during hospitalization or in the first month after transcatheter aortic valve implantation (B).

(0.1MB).
DiscussionNeed for pacemaker after transcatheter aortic valve implantation

Some patients undergoing TAVI need a permanent PM because of severe AV conduction disturbances,1–12,15 which appear to be related to device-induced trauma of the interventricular septum (IVS).14 During and after TAVI, new left bundle branch block is relatively frequent, secondary to conduction system damage during the procedure.16 As a result, patients with conduction abnormalities before the procedure are at higher risk of needing a permanent PM after TAVI.

Although the rate is 2.5–5 times lower with the ES than with the CV,2,5,9 4–11% of patients treated with the ES need a permanent PM.1–12 With both systems, this complication is more common than with surgical aortic valve replacement.17 In our series, 9.1% of patients treated with the ES needed a permanent PM during initial hospitalization, which is similar to the 8.8% incidence in the PARTNER trial and other studies.1–3,12,15

Beyond the first month after TAVI, some patients also needed PM implantation, but probably in these cases it was not directly due to the valve procedure. The need for PM beyond the first month after TAVI is probably related to the type of patients that are candidates for TAVI (advanced age, and high prevalence of renal failure), irrespective of the valve intervention.

The need for PM after TAVI is not associated with higher mortality after the procedure,3,9 but this complication prolongs hospital stay and can lead to complications such as pneumothorax, bleeding and infections. Moreover, PM rhythm may be associated with impaired ventricular function18 and a higher incidence of cardiac failure and cerebrovascular events during follow-up.19,20

Most of the conduction abnormalities associated with TAVI develop during the procedure (sometimes even before valve implantation)21 or soon after, but may also occur beyond the first 48 hours.22 These conduction disturbances are usually persistent, but some studies have shown that a significant proportion of patients undergoing permanent PM implantation after TAVI were not PM-dependent months after the procedure.8,11,7 This could justify more restrictive indications for permanent PM after TAVI, precluding unnecessary PM implantation by delaying the decision in some patients.23 However, our opinion is rather not to delay the indication for PM, because in most cases conduction abnormalities after TAVI are irreversible, and prolonged temporary transvenous pacing may also be associated with complications.24 Moreover, in some studies of patients treated with TAVI, those discharged with a permanent PM had a lower risk of sudden death after discharge.3

Characteristics associated with the need for permanent pacemaker

As the risk of permanent PM after TAVI is higher with the CV system,2,5,9 a number of characteristics have been identified associating this complication with the use of this device1,2,4,6,9,15,25,26: depth of implantation, use of first-generation devices, IVS thickness, left ventricular end-diastolic diameter, conduction abnormalities before the procedure, valve oversizing, age over 75, heart rate below 65 bpm before the procedure, atrial fibrillation, porcelain aorta, balloon pre-dilatation, and non-coronary cusp thickness.

In our series of patients treated with the ES, we found that both right bundle branch block and terminal chronic renal failure (on dialysis) were associated with the need for early permanent PM (during hospitalization or during the first month). Other variables, such as access route (transfemoral or transapical), age, valve diameter, aortic annulus diameter, or body mass index, were not associated with this complication.

Right bundle branch block has been associated with higher frequency of PM implantation in several series of TAVI with the CV.4,10,27,28 The AV node and left bundle branch are located near the aortic root and native aortic valve,13 while the non-coronary cusp is adjacent to the membranous portion of the IVS, which extends into a triangle bounded by the non-coronary and the right coronary cusps, where the His bundle is located. The left branch emerges in the membranous septum, crosses the fibrous trigone and passes along the left surface of the muscular septum. This is why previous right bundle branch block increases the risk of complete AV block if there is damage to the left ventricular outflow tract during TAVI.

The association between renal function and the need for PM after TAVI is less well understood. Renal failure is associated with electrolyte abnormalities that can induce rhythm and conduction disturbances. Most importantly, chronic renal failure is associated with deposition of extracellular matrix and collagen and development of fibrosis in the myocardium that may result in conduction abnormalities, arrhythmias and systolic and diastolic dysfunction.29 More severe renal dysfunction is associated with a higher prevalence of left bundle branch block and advanced AV block.30 Renal failure is also a predictor of progression to complete AV block in patients with bifascicular block,31 which is consistent with the greater need for permanent PM in longer-term follow-up that we observed late after TAVI.

Finally, in our study previous infarction was associated with the need for permanent PM more than one month after TAVI. Myocardial dysfunction occurring late after myocardial infarction may induce conduction abnormalities. Previous myocardial infarction was not, however, associated with the need for PM during the first month after TAVI.

Conclusions

Most data on the need for PM implantation after TAVI have been obtained with the self-expanding CV device. In our study, performed with the balloon-expandable ES prosthetic valve, 9.1% of patients needed a permanent PM during initial hospitalization or the first month after the procedure. Right bundle branch block and renal function were associated with the need for PM after TAVI. On the other hand, patients treated with TAVI are at high risk of needing PM in the long term, probably not directly due to TAVI, but probably due to the characteristics of this patient population.

Ethical disclosuresProtection of human and animal subjects

The authors declare that no experiments were performed on humans or animals for this study.

Confidentiality of data

The authors declare that no patient data appear in this article.

Right to privacy and informed consent

The authors declare that no patient data appear in this article.

Conflicts of interest

The authors have no conflicts of interest to declare.

References
[1]
J. Ledwoch, J. Franke, U. Gerckens, et al.
German Transcatheter Aortic Valve Interventions Registry I. Incidence and predictors of permanent pacemaker implantation following transcatheter aortic valve implantation: analysis from the German Transcatheter Aortic Valve Interventions Registry.
Catheter Cardiovasc Interv, 82 (2013), pp. E569-E577
[2]
G.C. Siontis, P. Jüni, T. Pilgrim, et al.
Predictors of permanent pacemaker implantation in patients with severe aortic stenosis undergoing TAVR: a meta-analysis.
J Am Coll Cardiol, 64 (2014), pp. 129-140
[3]
M. Urena, J.G. Webb, C. Tamburino, et al.
Permanent pacemaker implantation after transcatheter aortic valve implantation.
Circulation, 129 (2014), pp. 1233-1243
[4]
A.J. Munoz-Garcia, J.M. Hernandez, M.F. Jimenez, et al.
Factors predicting and having an impact on the need for a permanent pacemaker after CoreValve prosthesis implantation using the new Accutrak delivery catheter system.
JACC Cardiovasc Interv, 5 (2012), pp. 533-539
[5]
P.J. Khatri, J.G. Webb, J. Rodes-Cabau, et al.
Adverse effects associated with transcatheter aortic valve implantation: a meta-analysis of contemporary studies.
[6]
M.Z. Khawaja, R. Rajani, A. Cook, et al.
Permanent pacemaker insertion after CoreValve transcatheter aortic valve implantation: incidence and contributing factors (the UK CoreValve Collaborative).
Circulation, 123 (2011), pp. 951-960
[7]
V. Guetta, G. Goldenberg, A. Segev, et al.
Predictors and course of high-degree atrioventricular block after transcatheter aortic valve implantation using the CoreValve Revalving System.
Am J Cardiol, 108 (2011), pp. 1600-1605
[8]
R.M. Van der Boon, N.M. Van Mieghem, D.A. Theuns, et al.
Pacemaker dependency after transcatheter aortic valve implantation with the self-expanding Medtronic CoreValve System.
Int J Cardiol, 168 (2013), pp. 1269-1273
[9]
C.S. Gensas, A. Caixeta, D. Siqueira, et al.
Predictors of permanent pacemaker requirement after transcatheter aortic valve implantation: insights from a Brazilian registry.
Int J Cardiol, 175 (2014), pp. 248-252
[10]
V. Calvi, S. Conti, G.P. Pruiti, et al.
Incidence rate and predictors of permanent pacemaker implantation after transcatheter aortic valve implantation with self-expanding CoreValve prosthesis.
J Interv Card Electrophysiol, 34 (2012), pp. 189-195
[11]
G. Goldenberg, J. Kusniec, E. Kadmon, et al.
Pacemaker implantation after transcatheter aortic valve implantation.
Am J Cardiol, 112 (2013), pp. 1632-1634
[12]
M. Godin, H. Eltchaninoff, A. Furuta, et al.
Frequency of conduction disturbances after transcatheter implantation of an Edwards Sapien aortic valve prosthesis.
Am J Cardiol, 106 (2010), pp. 707-712
[13]
T. Kawashima, F. Sato.
Visualizing anatomical evidences on atrioventricular conduction system for TAVR.
Int J Cardiol, 174 (2014), pp. 1-6
[14]
R. Moreno, D. Dobarro, L. Calvo, et al.
Etiology of complete atrioventricular blockade after percutaneous aortic valve implantation. Insights from necropsy study.
Circulation, 120 (2009), pp. 29-30
[15]
T.M. Nazif, J.M. Dizon, R.T. Hahn, PARTNER Publications Office, et al.
Predictors and clinical outcomes of permanent pacemaker implantation after transcatheter aortic valve replacement: the PARTNER (Placement of AoRtic TraNscathetER Valves) trial and registry.
JACC Cardiovasc Interv, 8 (2015), pp. 60-69
[16]
I. Franzoni, A. Latib, F. Maisano, et al.
Comparison of incidence and predictors of left bundle branch block after transcatheter aortic valve implantation using the CoreValve versus the Edwards valve.
Am J Cardiol, 112 (2013), pp. 554-559
[17]
N.M. Van Mieghern, S.J. Head, W. de Jong, et al.
Persistent annual permanent pacemaker implantation rate after surgical aortic valve replacement in patients with severe aortic stenosis.
Ann Thorac Surg, 94 (2012), pp. 1143-1149
[18]
S. Biner, Y. Michowitz, E. Leshem-Rubinow, et al.
Hemodynamic impact and outcome of permanent pacemaker implantation following transcatheter aortic valve implantation.
Am J Cardiol, 113 (2014), pp. 132-137
[19]
J.C. Nielsen, H.R. Andersen, P.E. Thomsen, et al.
Heart failure and echocardiographic changes during long-term follow-up of patients with sick sinus syndrome randomized to single-chamber atrial or ventricular pacing.
Circulation, 97 (1998), pp. 987-995
[20]
L. Buellesfeld, S. Stortecky, D. Heg, et al.
Impact of permanent pacemaker implantation on clinical outcome among patients undergoing transcatheter aortic valve implantation.
J Am Coll Cardiol, 60 (2012), pp. 493-501
[21]
R.J. Nuis, N.M. Van Mieghem, C.J. Schultz, et al.
Timing and potential mechanisms of new conduction abnormalities during the implantation of the Medtronic CoreValve System in patients with aortic stenosis.
Eur Heart J, 32 (2011), pp. 2067-2074
[22]
E. Chorianopoulos, U. Krumsdorf, S.T. Pleger, et al.
Incidence of late occurring bradyarrhythmias after TAVI with the self-expanding CoreValve aortic bioprosthesis.
Clin Res Cardiol, 101 (2012), pp. 349-355
[23]
M. De Carlo, C. Giannini, F. Bedogni, et al.
Safety of a conservative strategy of permanent pacemaker implantation after transcatheter aortic CoreValve implantation.
Am Heart J, 163 (2012), pp. 492-499
[24]
R. Moreno, L. Calvo, P. Salinas, et al.
Causes of peri-operative mortality after transcatheter aortic valve implantation: a pooled analysis of 12 studies and 1223 patients.
J Invasive Cardiol, 23 (2011), pp. 180-184
[25]
H. Jilaihawi, D. Chin, M. Vasa-Nicotera, et al.
Predictors for permanent pacemaker requirement after transcatheter aortic valve implantation with the CoreValve bioprosthesis.
Am Heart J, 157 (2009), pp. 860-866
[26]
T. Schroeter, A. Linke, M. Haensig, et al.
Predictors of permanent pacemaker implantation after Medtronic CoreValve bioprosthesis implantation.
Europace, 14 (2012), pp. 1759-1763
[27]
R. Koos, A.H. Mahnken, O. Aktug, et al.
Electrocardiographic and imaging predictors for permanent pacemaker requirement after transcatheter aortic valve implantation.
J Heart Valve Dis, 20 (2011), pp. 83-90
[28]
L. Roten, P. Wenaweser, E. Delacrétaz, et al.
Incidence and predictors of atrioventricular conduction impairment after transcatheter aortic valve implantation.
Am J Cardiol, 106 (2010), pp. 1473-1480
[29]
A. Hundae, P.A. McCullough.
Cardiac and renal fibrosis in chronic cardiorenal syndromes.
Nephron Clin Pract, 127 (2014), pp. 106-112
[30]
C. Bruch, M. Rothenburger, M. Gotzmann, et al.
Chronic kidney disease in patients with chronic heart failure – impact on intracardiac conduction, diastolic function and prognosis.
Int J Cardiol, 118 (2007), pp. 375-380
[31]
J. Martí, M. Cladellas, V. Bazán, et al.
Novel predictors of progression of atrioventricular block in patients with chronic bifascicular block.
Rev Esp Cardiol, 63 (2010), pp. 400-408
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