que se leu este artigo
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Silencing CASC15 alleviated H/R-induced oxidative stress injury, as shown by decreased production of (A) MDA and increased activity of (B) SOD and (C) GSH-Px. ***p<0.001 vs. control group; <span class="elsevierStyleSup">###</span>p<0.001 vs. Si-NC group. GSH-Px: glutathione peroxidase; H/R: hypoxia/reoxygenation; MDA: methylenedioxyamphetamine; si-CASC15: small interfering RNA against CASC15; si-NC: small interfering RNA as negative control; SOD: superoxide dismutase.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Shuai Sun, Xue Mei" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Shuai" "apellidos" => "Sun" ] 1 => array:2 [ "nombre" => "Xue" "apellidos" => "Mei" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255123003918?idApp=UINPBA00004E" "url" => "/08702551/0000004300000002/v1_202402041059/S0870255123003918/v1_202402041059/en/main.assets" ] "asociados" => array:1 [ 0 => array:17 [ "pii" => "S0870255123003918" "issn" => "08702551" "doi" => "10.1016/j.repc.2023.04.017" "estado" => "S300" "fechaPublicacion" => "2024-02-01" "aid" => "2246" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2024;43:77-84" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Effect of CASC15 on apoptosis and oxidative stress of cardiomyocytes after hypoxia/reperfusion injury" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "77" "paginaFinal" => "84" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Efeito da CASC15 na apoptose e <span class="elsevierStyleItalic">stress</span> oxidativo em cardiomiócitos após lesão de hipóxia/reperfusão" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 857 "Ancho" => 3820 "Tamanyo" => 131863 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Measurement of oxidative stress index. Silencing CASC15 alleviated H/R-induced oxidative stress injury, as shown by decreased production of (A) MDA and increased activity of (B) SOD and (C) GSH-Px. ***p<0.001 vs. control group; <span class="elsevierStyleSup">###</span>p<0.001 vs. Si-NC group. GSH-Px: glutathione peroxidase; H/R: hypoxia/reoxygenation; MDA: methylenedioxyamphetamine; si-CASC15: small interfering RNA against CASC15; si-NC: small interfering RNA as negative control; SOD: superoxide dismutase.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Shuai Sun, Xue Mei" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Shuai" "apellidos" => "Sun" ] 1 => array:2 [ "nombre" => "Xue" "apellidos" => "Mei" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255123003918?idApp=UINPBA00004E" "url" => "/08702551/0000004300000002/v1_202402041059/S0870255123003918/v1_202402041059/en/main.assets" ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>" "titulo" => "Could lncRNA CASC15 be a new target to limit myocardial ischemia/reperfusion injury?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "85" "paginaFinal" => "86" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Fábio Trindade" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Fábio" "apellidos" => "Trindade" "email" => array:1 [ 0 => "ftrindade@med.up.pt" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Cardiovascular R&D Center – UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Poderá o lncRNA CASC15 ser um novo alvo para limitar a lesão miocárdica de isquemia/reperfusão?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Ischemic heart disease is the leading cause of death worldwide. In the event of an acute myocardial infarction (AMI), timely revascularization of the myocardium is imperative to salvage the ischemic region and reduce infarct size.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> However, in addition to the ischemic injury caused by nutrient and oxygen deprivation, when blood flow is restored (through percutaneous coronary intervention or coronary artery bypass grafting), the myocardium is paradoxically harmed through a myriad of molecular and cellular events, including generation of additional reactive oxygen species, increased calcium cycling, complement activation, acute inflammation, immune system activation, apoptosis and other forms of proinflammatory cell death.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">1,2</span></a> Therefore, despite advancements in myocardial revascularization, high morbidity and mortality is still observed after AMI, which can be explained by an adverse cardiac remodeling response (a known substrate of heart failure).<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">With the aim of improving the prognosis of AMI patients, significant efforts have been made in recent decades through numerous pharmacological cardioprotection strategies to reduce post-intervention ischemia/reperfusion (I/R) injury and thereby limit adverse myocardial remodeling. Some have shown potential in the preclinical stage but failed or were inconsistent during clinical testing, such as adenosine, nitrite, cyclosporine A, and protein kinase C-delta inhibitors.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> Other promising drugs are still in the preclinical stage, such as NAD+ precursors, malonate (a succinate dehydrogenase inhibitor), NLRP3 inflammasome inhibitors, caspase and calpain inhibitors, and angiopoietin-like peptide 4.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">2,4</span></a> Nonetheless, final translation to clinical practice is yet to be achieved, and no effective therapeutic strategy to limit infarct size is currently established.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Interest in RNA-based therapeutics is growing, enhanced by the success of mRNA-based COVID-19 vaccines. With advances in sequencing technologies, we are now better equipped to dissect the regulatory role of non-coding RNAs, including microRNAs (miRs) and long non-coding RNAs (lnc-RNAs), in the heart. Consequently, miRs and lncRNAs are increasingly seen as a class of surrogate biomarkers and therapeutic targets for various cardiac diseases. For instance, Santos-Faria et al. found that miR-4268 correlates with left ventricular mass regression following aortic valve replacement.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a> In the context of myocardial I/R injury, it is being reported that many lncRNAs regulate cardiomyocyte death, among other effects. For instance, the lncRNA necrosis-related factor (NRF) has been proposed as a target for I/R injury because NRF acts as a sponge for miR-873, precluding its protection against cell death.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">During revascularization, targeting cell death pathways is particularly appealing because infarct size, which largely depends on the promptness of the intervention, is strongly associated with all-cause mortality and hospitalization for heart failure within one year.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> In this regard, the study by Sun and Mei published in this issue of the <span class="elsevierStyleItalic">Journal</span><a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a> contributes with evidence of a new candidate lncRNA target to mitigate I/R injury by promoting cell survival. The authors focused on cancer susceptibility 15 (CASC15), better known for its pleiotropic role in different types of cancer, from cell proliferation and migration to apoptosis.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a> There is much less knowledge of CASC15s role in the heart, the only study being by Li et al., who reported that CASC15 has a pro-hypertrophic effect by competitively binding to miR-423-5p, favoring TLR4 mRNA translation.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> Based on the observation that serum CASC15 levels are higher in patients with atherosclerosis and AMI, Sun and Mei sought to investigate the potential mechanistic role of this lncRNA in the context of I/R injury. For this purpose, they used an in vitro model of I/R injury by exposing H9c2 cells to hypoxia/reoxygenation (H/R). They first reported that CASC15 was significantly increased in cells exposed to H/R, which corroborates previous observations in serum. They then found that inhibiting CASC15 conferred protection to H9c2 cells against oxidative stress after a H/R insult and suppressed apoptosis, favoring cell survival. Mechanistically, the protection was shown to be mediated, at least in part, by enhancing miR-542-3p levels. Previously, CASC15 inhibition was found to be protective in an in vitro model of acute ischemic stroke through upregulation of another miRNA (miR-338-3p).<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Given the potential of CASC15 inhibition in the context of I/R injury, the multiplicity of mRNA (and potentially protein) targets requires further research to obtain a complete picture of the CASC15-mediated regulation of cell survival/death pathways. Furthermore, considering the sometimes opposing effects of CASC15 in different tumor types, it should be borne in mind that CASC15 may have disparate effects on other cells implicated in I/R injury, including endothelial cells, vascular smooth muscle cells, fibroblasts, neutrophils, and other immune system players. Therefore, clarification of this issue would be of great value before moving on to preclinical models. Regardless, Sun and Mei's findings add value to the field, identifying CACS15 as a new potential lncRNA target to mitigate the dismal effects of I/R on the myocardium.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0030" class="elsevierStylePara elsevierViewall">FT is supported by a postdoctoral grant from <span class="elsevierStyleGrantSponsor" id="gs1">Fundação para a Ciência e Tecnologia (FCT)</span> through Unidade de Investigação e Desenvolvimento Cardiovascular (UnIC, <span class="elsevierStyleGrantNumber" refid="gs1">UIDP/00051/2020</span>).</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflicts of interest" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0060" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Myocardial ischaemia–reperfusion injury and cardioprotection in perspective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G. 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Ano/Mês | Html | Total | |
---|---|---|---|
2024 Novembro | 6 | 5 | 11 |
2024 Outubro | 53 | 31 | 84 |
2024 Setembro | 38 | 27 | 65 |
2024 Agosto | 46 | 25 | 71 |
2024 Julho | 53 | 27 | 80 |
2024 Junho | 42 | 23 | 65 |
2024 Maio | 38 | 35 | 73 |
2024 Abril | 43 | 32 | 75 |
2024 Maro | 37 | 23 | 60 |
2024 Fevereiro | 69 | 64 | 133 |
2024 Janeiro | 17 | 13 | 30 |
2023 Dezembro | 18 | 15 | 33 |
2023 Novembro | 29 | 48 | 77 |
2023 Outubro | 40 | 38 | 78 |
2023 Setembro | 26 | 40 | 66 |