que se leu este artigo
array:24 [ "pii" => "S0870255122004644" "issn" => "08702551" "doi" => "10.1016/j.repc.2022.10.003" "estado" => "S300" "fechaPublicacion" => "2022-12-01" "aid" => "2057" "copyright" => "Sociedade Portuguesa de Cardiologia" "copyrightAnyo" => "2022" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "dis" "cita" => "Rev Port Cardiol. 2022;41:1053-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S0870255122004632" "issn" => "08702551" "doi" => "10.1016/j.repc.2021.09.024" "estado" => "S300" "fechaPublicacion" => "2022-12-01" "aid" => "2055" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Rev Port Cardiol. 2022;41:1055-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Image in Cardiology</span>" "titulo" => "Heart failure and pericardial mass leading to diagnosis of a rare hematologic disease" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1055" "paginaFinal" => "1056" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Insuficiência cardíaca e massa pericárdica no diagnóstico de doença hematológica rara" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2505 "Ancho" => 2508 "Tamanyo" => 528977 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A: Ecocardiography showing mass at the auriculoventricular sulcus; B: Perirenal and retroperitoneal fibrosis seen in computed tomography; C: Magnetic resonance imaging (MRI) showing cardiac mass and hypointense tissue surrounding right atrium; D and E: MRI, inversion-recovery sequences showing intense enhancement in heart mass and aortic wall.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ignacio Barriuso, Eva Pueo, María Isabel Gil, Diego Fernández-Rodríguez, Dolors Viles, Fernando Worner" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Ignacio" "apellidos" => "Barriuso" ] 1 => array:2 [ "nombre" => "Eva" "apellidos" => "Pueo" ] 2 => array:2 [ "nombre" => "María Isabel" "apellidos" => "Gil" ] 3 => array:2 [ "nombre" => "Diego" "apellidos" => "Fernández-Rodríguez" ] 4 => array:2 [ "nombre" => "Dolors" "apellidos" => "Viles" ] 5 => array:2 [ "nombre" => "Fernando" "apellidos" => "Worner" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122004632?idApp=UINPBA00004E" "url" => "/08702551/0000004100000012/v2_202212230532/S0870255122004632/v2_202212230532/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0870255122004590" "issn" => "08702551" "doi" => "10.1016/j.repc.2019.03.013" "estado" => "S300" "fechaPublicacion" => "2022-12-01" "aid" => "2053" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Rev Port Cardiol. 2022;41:1047-51" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "A case of lymphocytic myocarditis in a patient treated with an immune checkpoint inhibitor, a recent class of chemotherapy agents" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1047" "paginaFinal" => "1051" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Um caso de miocardite linfocítica numa doente tratada com inibidores dos <span class="elsevierStyleItalic">checkpoint</span> imunes, uma recente classe de agentes de quimioterapia" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1790 "Ancho" => 3008 "Tamanyo" => 1123941 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Histological analysis of endomyocardial biopsy. (1A and 1B) Multifocal inflammatory infiltrate in myocardium, with myocyte dropout (100× and 200× hematoxylin and eosin staining). (2A, 2B and 2C) The inflammatory infiltrate is polyclonal, mostly composed of lymphocytes (CD3 and CD20 positive) and macrophages (CD68 positive) (immunohistochemical analysis).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Tatiana Duarte, Cátia Costa, Sara Gonçalves, Luís Raposo, António Ferreira, Catarina Albuquerque, Nuno Vau, Rui Caria" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Tatiana" "apellidos" => "Duarte" ] 1 => array:2 [ "nombre" => "Cátia" "apellidos" => "Costa" ] 2 => array:2 [ "nombre" => "Sara" "apellidos" => "Gonçalves" ] 3 => array:2 [ "nombre" => "Luís" "apellidos" => "Raposo" ] 4 => array:2 [ "nombre" => "António" "apellidos" => "Ferreira" ] 5 => array:2 [ "nombre" => "Catarina" "apellidos" => "Albuquerque" ] 6 => array:2 [ "nombre" => "Nuno" "apellidos" => "Vau" ] 7 => array:2 [ "nombre" => "Rui" "apellidos" => "Caria" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122004590?idApp=UINPBA00004E" "url" => "/08702551/0000004100000012/v2_202212230532/S0870255122004590/v2_202212230532/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>" "titulo" => "A double-edged sword at the intersection between cancer and cardiovascular disease" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1053" "paginaFinal" => "1054" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Ricardo Ladeiras-Lopes" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Ricardo" "apellidos" => "Ladeiras-Lopes" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Hospital da Luz, Guimarães, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidade de Investigação e Desenvolvimento Cardiovascular, Faculdade de Medicina da Universidade do Porto, Porto, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "A «faca de dois gumes» da combinação entre cancro e doença cardiovascular" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cancer and cardiovascular diseases are the most common causes of death worldwide. In 2019, they were responsible for approximately half of the 58 million deaths in the world.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Checkpoint-inhibitor immunotherapies are being increasingly used to improve the prognosis of several diseases. Briefly, these drugs modulate checkpoints that control our immune response, therefore increasing the ability of our immune system to kill cancer cells. It seems logical that drugs with this mechanism of action would be associated with nonspecific activation of the immune system, leading to the so-called off-target immune-related adverse events (detectable in 70–90% of patients). Myocarditis occurs in approximately 1% of patients on immune checkpoint inhibitors (ICI) and should be a leading differential diagnosis in “de novo” cardiovascular symptoms.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The clinical case presented by Duarte et al.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">3</span></a> highlights several challenges related to ICI-associated myocarditis: (1) most patients who develop myocarditis on ICIs have normal left ventricular ejection fraction before treatment is started; (2) there is no standard screening and surveillance strategy, but baseline echocardiogram and troponin measurement is recommended, thus providing a reference for future comparison if cardiovascular symptoms arise; (3) evidence-based guidance for the treatment of this complication is lacking, but several consensus documents recommend early initiation of immunosuppression (corticosteroids as a first-line).</p><p id="par0020" class="elsevierStylePara elsevierViewall">Interestingly, the diagnosis was confirmed by endomyocardial biopsy, still the old-school “gold standard” for the diagnosis of myocarditis. The debate surrounding its use and importance is out of the scope of this editorial. The critical highlight is that cardiac magnetic resonance (CMR) performed with standard tissue characterization and parametric mapping should be viewed as the “non-invasive biopsy” of the heart. CMR with myocardial mapping techniques is a helpful imaging test for the detection of myocardial inflammation in patients with suspected myocarditis, with a robust diagnostic accuracy that can circumvent the need for an endomyocardial biopsy.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">4</span></a> The importance of the increasing availability of CMR in Portuguese cardiology departments cannot be overstated.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Cardio-oncology is an exciting and dynamic topic in cardiovascular medicine. A milestone was reached in 2022 with the publication of the first European guidelines specifically dedicated to this topic. The clinical case by Duarte et al.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">3</span></a> illustrates one disease (myocarditis) associated with one type of cancer treatment (checkpoint immunotherapy) that is still largely unknown. Clearly, registries and clinical trials will be paramount to consolidating the growing body of evidence in the field of cardiovascular immune-related adverse events associated with ICI. In a broader perspective, the understanding of the complex interaction between cancer (and its therapies) and cardiovascular disease is pivotal for addressing the two most common causes of death in the world.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0025" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Our World in Data (number of deaths by cause, World, 2019). Available from: <a target="_blank" href="https://ourworldindata.org/grapher/annual-number-of-deaths-by-cause">https://ourworldindata.org/grapher/annual-number-of-deaths-by-cause</a> [accessed 20.08.22]." ] ] ] 1 => array:3 [ "identificador" => "bib0030" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The evolving immunotherapy landscape and the epidemiology, diagnosis, and management of cardiotoxicity: JACC: CardioOncology Primer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Zhang" 1 => "K.L. Reynolds" 2 => "A.R. Lyon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaccao.2020.11.012" "Revista" => array:6 [ "tituloSerie" => "JACC CardioOncol" "fecha" => "2021" "volumen" => "3" "paginaInicial" => "35" "paginaFinal" => "47" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33842895" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0035" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case of lymphocytic myocarditis in a patient treated with an immune checkpoint inhibitor, a recent class of chemotherapy agents" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "T. Duarte" 1 => "C. Costa" 2 => "S. Gonçalves" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.repc.2019.03.013" "Revista" => array:6 [ "tituloSerie" => "Rev Port Cardiol" "fecha" => "2022" "volumen" => "41" "paginaInicial" => "1047" "paginaFinal" => "1051" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36257498" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0040" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular magnetic resonance in nonischemic myocardial inflammation: expert recommendations" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "V.M. Ferreira" 1 => "J. Schulz-Menger" 2 => "G. Holmvang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2018.09.072" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2018" "volumen" => "72" "paginaInicial" => "3158" "paginaFinal" => "3176" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30545455" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/08702551/0000004100000012/v2_202212230532/S0870255122004644/v2_202212230532/en/main.assets" "Apartado" => array:4 [ "identificador" => "93856" "tipo" => "SECCION" "pt" => array:2 [ "titulo" => "Case reports" "idiomaDefecto" => true ] "idiomaDefecto" => "pt" ] "PDF" => "https://static.elsevier.es/multimedia/08702551/0000004100000012/v2_202212230532/S0870255122004644/v2_202212230532/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122004644?idApp=UINPBA00004E" ]
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