que se leu este artigo
array:24 [ "pii" => "S0870255122002839" "issn" => "08702551" "doi" => "10.1016/j.repc.2022.07.004" "estado" => "S300" "fechaPublicacion" => "2022-09-01" "aid" => "2003" "copyrightAnyo" => "2022" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "dis" "cita" => "Rev Port Cardiol. 2022;41:739-40" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S0870255122001676" "issn" => "08702551" "doi" => "10.1016/j.repc.2021.05.018" "estado" => "S300" "fechaPublicacion" => "2022-09-01" "aid" => "1947" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2022;41:741-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Chronic thromboembolic pulmonary hypertension: A 10-year analysis from a Portuguese referral center" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "741" "paginaFinal" => "748" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Hipertensão pulmonar tromboembólica crónica: análise de 10 anos de um centro de referência português" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1890 "Ancho" => 2508 "Tamanyo" => 207640 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Study design flow chart. CTEPH: chronic thromboembolic pulmonary hypertension; PEA: pulmonary endarterectomy; PH: pulmonary hypertension; RHC: right heart catheterization.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Gonçalo Samouco, Marta Fonseca, Joana Batista Correia, Cátia Santos-Ferreira, Patrícia Marques-Alves, Rui Baptista, Graça Castro, Lino Gonçalves" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Gonçalo" "apellidos" => "Samouco" ] 1 => array:2 [ "nombre" => "Marta" "apellidos" => "Fonseca" ] 2 => array:2 [ "nombre" => "Joana" "apellidos" => "Batista Correia" ] 3 => array:2 [ "nombre" => "Cátia" "apellidos" => "Santos-Ferreira" ] 4 => array:2 [ "nombre" => "Patrícia" "apellidos" => "Marques-Alves" ] 5 => array:2 [ "nombre" => "Rui" "apellidos" => "Baptista" ] 6 => array:2 [ "nombre" => "Graça" "apellidos" => "Castro" ] 7 => array:2 [ "nombre" => "Lino" "apellidos" => "Gonçalves" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122001676?idApp=UINPBA00004E" "url" => "/08702551/0000004100000009/v1_202209010540/S0870255122001676/v1_202209010540/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0870255122001573" "issn" => "08702551" "doi" => "10.1016/j.repc.2021.05.016" "estado" => "S300" "fechaPublicacion" => "2022-09-01" "aid" => "1938" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2022;41:729-37" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "The predictive value of epicardial fat volume for clinical severity of COVID-19" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "729" "paginaFinal" => "737" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Valor preditivo do volume de gordura epicárdica em relação à gravidade clínica da COVID-19" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1009 "Ancho" => 1258 "Tamanyo" => 75943 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Correlation between epicardial fat volume and interleukin-6 level.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mehmet Akif Erdöl, Fatma Civelek Eser, Abdullah Nabi Aslan, Mehmet Erdoğan, Adalet Altunsoy Aypak, Muhammed Said Beşler, Ayşe Kaya Kalem, Ahmet Göktuğ Ertem, Hatice Rahmet Güner" "autores" => array:9 [ 0 => array:2 [ "nombre" => "Mehmet Akif" "apellidos" => "Erdöl" ] 1 => array:2 [ "nombre" => "Fatma" "apellidos" => "Civelek Eser" ] 2 => array:2 [ "nombre" => "Abdullah Nabi" "apellidos" => "Aslan" ] 3 => array:2 [ "nombre" => "Mehmet" "apellidos" => "Erdoğan" ] 4 => array:2 [ "nombre" => "Adalet" "apellidos" => "Altunsoy Aypak" ] 5 => array:2 [ "nombre" => "Muhammed Said" "apellidos" => "Beşler" ] 6 => array:2 [ "nombre" => "Ayşe" "apellidos" => "Kaya Kalem" ] 7 => array:2 [ "nombre" => "Ahmet Göktuğ" "apellidos" => "Ertem" ] 8 => array:2 [ "nombre" => "Hatice Rahmet" "apellidos" => "Güner" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122001573?idApp=UINPBA00004E" "url" => "/08702551/0000004100000009/v1_202209010540/S0870255122001573/v1_202209010540/en/main.assets" ] "asociados" => array:1 [ 0 => array:19 [ "pii" => "S0870255122001573" "issn" => "08702551" "doi" => "10.1016/j.repc.2021.05.016" "estado" => "S300" "fechaPublicacion" => "2022-09-01" "aid" => "1938" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2022;41:729-37" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "The predictive value of epicardial fat volume for clinical severity of COVID-19" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "729" "paginaFinal" => "737" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Valor preditivo do volume de gordura epicárdica em relação à gravidade clínica da COVID-19" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1009 "Ancho" => 1258 "Tamanyo" => 75943 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Correlation between epicardial fat volume and interleukin-6 level.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mehmet Akif Erdöl, Fatma Civelek Eser, Abdullah Nabi Aslan, Mehmet Erdoğan, Adalet Altunsoy Aypak, Muhammed Said Beşler, Ayşe Kaya Kalem, Ahmet Göktuğ Ertem, Hatice Rahmet Güner" "autores" => array:9 [ 0 => array:2 [ "nombre" => "Mehmet Akif" "apellidos" => "Erdöl" ] 1 => array:2 [ "nombre" => "Fatma" "apellidos" => "Civelek Eser" ] 2 => array:2 [ "nombre" => "Abdullah Nabi" "apellidos" => "Aslan" ] 3 => array:2 [ "nombre" => "Mehmet" "apellidos" => "Erdoğan" ] 4 => array:2 [ "nombre" => "Adalet" "apellidos" => "Altunsoy Aypak" ] 5 => array:2 [ "nombre" => "Muhammed Said" "apellidos" => "Beşler" ] 6 => array:2 [ "nombre" => "Ayşe" "apellidos" => "Kaya Kalem" ] 7 => array:2 [ "nombre" => "Ahmet Göktuğ" "apellidos" => "Ertem" ] 8 => array:2 [ "nombre" => "Hatice Rahmet" "apellidos" => "Güner" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122001573?idApp=UINPBA00004E" "url" => "/08702551/0000004100000009/v1_202209010540/S0870255122001573/v1_202209010540/en/main.assets" ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>" "titulo" => "Epicardial fat as a predictor of COVID-19 disease severity: Just a surrogate for obesity or a true independent predictor?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "739" "paginaFinal" => "740" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Christopher Strong" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Christopher" "apellidos" => "Strong" "email" => array:1 [ 0 => "christopherstrong479@yahoo.com" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Serviço de Cardiologia, CHLO, Hospital de Santa Cruz, Carnaxide, Portugal" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "A gordura epicárdica como fator preditivo da gravidade da doença COVID-19: apenas um marcador de obesidade ou um verdadeiro fator preditivo independente?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Since it was first reported in China in 2019, COVID-19, the infection caused by the new coronavirus SARS-CoV-2, has become a global pandemic, with more than 500 million confirmed cases worldwide as of June 2022.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Health care systems around the world have been placed under tremendous strain by COVID-19, and the virus will likely leave lasting effects for years to come.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Fortunately, most people infected with the virus experience mild to moderate respiratory illness and recover without needing hospital admission. Some, however, become seriously ill with severe or critical disease following the development of an acute respiratory distress syndrome caused by systemic hyperinflammation and cytokine release.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Vaccination has had a major impact in reducing morbidity and mortality resulting from COVID-19 infection,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> with billions of vaccine doses administered since the first approval in December 2020. Its long-term protection against severe infection is still not established, especially with the advent of new mutated strains, and there will likely be a need for regular vaccine boosts in years to come, particularly for higher-risk groups.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Multiple studies have demonstrated that comorbid cardiovascular disease and cardiovascular risk factors are linked to a more severe course and higher mortality from COVID-19.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Obesity, in particular, has been established as a risk factor for COVID-19 disease severity, with higher risk for hospitalization, intensive care unit (ICU) admission, invasive mechanical ventilation and death.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> This may be due not only to the stronger association of obesity with cardiovascular risk factors (such as hypertension and type 2 diabetes) and cardiovascular disease (coronary artery disease and heart failure) – which by themselves are a risk factor for COVID-19 disease severity – but also to the proinflammatory state associated with obesity resulting from the release of various inflammatory molecules.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3,5</span></a> In the setting of COVID-19, obesity can therefore result in further inflammation and subsequent cytokine storm, increasing the risk of severe disease.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Epicardial adipose tissue is increased in obese people, and might also play a role in adverse outcomes.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In their article published in this issue of the <span class="elsevierStyleItalic">Journal</span>,<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> Erdöl et al. report a single-center retrospective study that took place at Ankara City Hospital in Turkey, with data collected during an unspecified period. A total of 101 consecutive patients diagnosed with COVID-19 infection were enrolled (26 of them with severe or critical disease and admitted to the ICU). Clinical, laboratory and imaging (computed tomography [CT] scan) data were collected. The main objective was to assess the association between epicardial fat volume (EFV), inflammatory biomarkers (C-reactive protein, procalcitonin, serum ferritin, and interleukin-6) and prognosis (composite endpoint of death or admission to the ICU). Patients admitted to the ICU were significantly older and had a higher prevalence of comorbidities such as coronary artery disease and chronic obstructive pulmonary disease, compared to those with milder disease admitted to the ward (n=75). Demographic and clinical characteristics such as gender, body mass index, smoking and diabetes were not different between the groups. Inflammatory biomarkers were significantly more elevated in patients admitted to the ICU, and so was EFV. The authors<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> also found a moderate correlation between each of the inflammatory biomarkers and EFV (r=0.26-0.49). A cut-off value of 102 cm<span class="elsevierStyleSup">3</span> for EFV was found to have a 94% negative predictive value for predicting more severe disease. On multivariate logistic regression analysis, EFV and age independently predicted admission to the ICU.</p><p id="par0030" class="elsevierStylePara elsevierViewall">A recently published study by Mehta et al. also found that epicardial adipose tissue is a risk factor for severe COVID-19, independently of age, body mass index and comorbid conditions.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Angiotensin-converting enzyme 2, recognized as a key receptor in the cell entry of SARS-CoV-2, has also been found in epicardial adipose tissue, further confirming this fat depot as a potential player in the pathophysiology of the disease. In the setting of COVID-19, epicardial adipose tissue may play a role in generating an imbalance between pro- and anti-inflammatory adipokines, potentially leading to the cytokine storm described in patients with severe COVID-19.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Since most patients with severe COVID-19 will undergo a CT scan, with no need for gating, it is an easily accessible parameter that further helps in the risk stratification of these patients.</p><p id="par0045" class="elsevierStylePara elsevierViewall">This paper has several limitations, mainly that it reports a single-center retrospective study with a small sample size. Furthermore, the results might have been different in the post-vaccination era, with many of the vaccinated patients admitted to the ICU with severe COVID-19 nowadays being those under chronic immunosuppression.</p><p id="par0050" class="elsevierStylePara elsevierViewall">This study, however, contributes to current knowledge of the role of EFV in adverse outcomes, and to further risk stratification of COVID-19 patients.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "WHO Coronavirus (COVID-19) Dashboard. Available from <a target="_blank" href="https://covid19.who.int/">https://covid19.who.int</a> [accessed June 2022]" ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The impact of vaccination on coronavirus disease 2019 (COVID-19) outbreaks in the United States" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.M. Moghadas" 1 => "T.N. Vilches" 2 => "K. Zhang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/cid/ciab079" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2021" "volumen" => "73" "paginaInicial" => "2257" "paginaFinal" => "2264" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33515252" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "European Society of Cardiology guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 1-epidemiology, pathophysiology, and diagnosis. The Task Force for the management of COVID-19 of the European Society of Cardiology" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C. Baigent" 1 => "S. Windecker" 2 => "D. Andreini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/cvr/cvab342" "Revista" => array:6 [ "tituloSerie" => "Cardiovasc Res" "fecha" => "2022" "volumen" => "118" "paginaInicial" => "1385" "paginaFinal" => "1412" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34864874" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity in patients with COVID-19: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "Y. Huang" 1 => "Y. Lu" 2 => "Y.-M. Huang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.metabol.2020.154378" "Revista" => array:5 [ "tituloSerie" => "Metabolism" "fecha" => "2020" "volumen" => "113" "paginaInicial" => "154378" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33002478" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity and COVID-19: a jigsaw puzzle with still missing pieces" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K. Michalakis" 1 => "G. Panagiotou" 2 => "I. Ilias" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/cob.12420" "Revista" => array:5 [ "tituloSerie" => "Clin Obes" "fecha" => "2021" "volumen" => "11" "paginaInicial" => "e12420" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33073512" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E. Korakas" 1 => "I. Ikonomidis" 2 => "F. Kousathana" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/ajpendo.00198.2020" "Revista" => array:6 [ "tituloSerie" => "Am J Physiol Endocrinol Metab" "fecha" => "2020" "volumen" => "319" "paginaInicial" => "E105" "paginaFinal" => "E109" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32459524" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Packer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2018.03.509" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2018" "volumen" => "71" "paginaInicial" => "2360" "paginaFinal" => "2372" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29773163" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The predictive value of epicardial fat volume for clinical severity of COVID-19" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.A. Erdöl" 1 => "F.C. Eser" 2 => "A.N. Aslan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Port Cardiol" "fecha" => "2022" "volumen" => "41" "paginaInicial" => "729" "paginaFinal" => "737" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epicardial adipose tissue thickness is associated with increased COVID-19 severity and mortality" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R. Mehta" 1 => "O.Y. Bello-Chavolla" 2 => "L. Mancillas-Adame" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Obes (Lond)" "fecha" => "2022" "volumen" => "46" "paginaInicial" => "866" "paginaFinal" => "873" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does epicardial fat contribute to COVID-19 myocardial inflammation?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.E. Malavazos" 1 => "J.J. Goldberger" 2 => "G. Iacobellis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Eur Heart J" "fecha" => "2020" "volumen" => "21" "paginaInicial" => "2333" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/08702551/0000004100000009/v1_202209010540/S0870255122002839/v1_202209010540/en/main.assets" "Apartado" => array:4 [ "identificador" => "92834" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/08702551/0000004100000009/v1_202209010540/S0870255122002839/v1_202209010540/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122002839?idApp=UINPBA00004E" ]
Ano/Mês | Html | Total | |
---|---|---|---|
2024 Novembro | 8 | 5 | 13 |
2024 Outubro | 44 | 34 | 78 |
2024 Setembro | 54 | 21 | 75 |
2024 Agosto | 49 | 26 | 75 |
2024 Julho | 51 | 34 | 85 |
2024 Junho | 51 | 27 | 78 |
2024 Maio | 55 | 16 | 71 |
2024 Abril | 51 | 33 | 84 |
2024 Maro | 44 | 17 | 61 |
2024 Fevereiro | 38 | 20 | 58 |
2024 Janeiro | 39 | 28 | 67 |
2023 Dezembro | 33 | 22 | 55 |
2023 Novembro | 42 | 35 | 77 |
2023 Outubro | 17 | 18 | 35 |
2023 Setembro | 16 | 22 | 38 |
2023 Agosto | 21 | 9 | 30 |
2023 Julho | 17 | 18 | 35 |
2023 Junho | 18 | 10 | 28 |
2023 Maio | 27 | 24 | 51 |
2023 Abril | 17 | 6 | 23 |
2023 Maro | 37 | 21 | 58 |
2023 Fevereiro | 27 | 20 | 47 |
2023 Janeiro | 15 | 12 | 27 |
2022 Dezembro | 38 | 20 | 58 |
2022 Novembro | 44 | 35 | 79 |
2022 Outubro | 57 | 34 | 91 |
2022 Setembro | 125 | 109 | 234 |
2022 Agosto | 27 | 33 | 60 |