que se leu este artigo
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(B) selective injection in the left main coronary artery after implantation of an Amplatzer Vascular Plug II® (AVPII) device in the CAF, with residual flow via two orifices to the RA; (C) a second device, an Amplatzer Ductal Occluder® (ADO), was implanted in the inferior orifice; (D) follow-up angiography nine months later revealing complete closure of the CAF after the emergence of the circumflex artery (CX).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Sofia Torres, Mariana Vasconcelos, Marta Tavares Silva, Jorge Moreira, João Carlos Silva, Filipe Macedo" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Sofia" "apellidos" => "Torres" ] 1 => array:2 [ "nombre" => "Mariana" "apellidos" => "Vasconcelos" ] 2 => array:2 [ "nombre" => "Marta" "apellidos" => "Tavares Silva" ] 3 => array:2 [ "nombre" => "Jorge" "apellidos" => "Moreira" ] 4 => array:2 [ "nombre" => "João Carlos" "apellidos" => "Silva" ] 5 => array:2 [ "nombre" => "Filipe" "apellidos" => "Macedo" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087025512200258X?idApp=UINPBA00004E" "url" => "/08702551/0000004100000010/v1_202210061538/S087025512200258X/v1_202210061538/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0870255122002578" "issn" => "08702551" "doi" => "10.1016/j.repc.2021.06.022" "estado" => "S300" "fechaPublicacion" => "2022-10-01" "aid" => "1976" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2022;41:833-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Alteration in serum oxidative stress balance in patients with different circulating high-density lipoprotein cholesterol levels" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "833" "paginaFinal" => "839" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Alteração do equilíbrio do <span class="elsevierStyleItalic">stress</span> oxidativo sérico em doentes com diferentes níveis circulatórios de colesterol HDL" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1333 "Ancho" => 1675 "Tamanyo" => 93348 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Linear regression analysis between serum TAC and HDL-C levels. Serum TAC levels (β=-0.309, 95% CI: -78.471-28.734, p<0.001) were dependently associated with HDL-C values. For abbreviations see text.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mustafa Karabacak, Bayram Ali Uysal, Ahmet Kenan Turkdogan" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Mustafa" "apellidos" => "Karabacak" ] 1 => array:2 [ "nombre" => "Bayram Ali" "apellidos" => "Uysal" ] 2 => array:2 [ "nombre" => "Ahmet Kenan" "apellidos" => "Turkdogan" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122002578?idApp=UINPBA00004E" "url" => "/08702551/0000004100000010/v1_202210061538/S0870255122002578/v1_202210061538/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>" "titulo" => "Oxidative stress and high-density lipoprotein cholesterol: Cause or consequence?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "841" "paginaFinal" => "842" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Ana Cristina Gonçalves" "autores" => array:1 [ 0 => array:4 [ "nombre" => "Ana Cristina" "apellidos" => "Gonçalves" "email" => array:1 [ 0 => "acgoncalves@fmed.uc.pt" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Laboratory of Oncobiology and Hematology (LOH) and University Clinic of Hematology, Faculty of Medicine (FMUC), University of Coimbra, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Coimbra Institute for Clinical and Biomedical Research (iCBR) – Group of Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra (FMUC), Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Center for Innovative Biomedicine and Biotecnology (CIBB), Coimbra, Portugal" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Clinical Academic Center of Coimbra, CACC, Coimbra, Portugal" "etiqueta" => "d" "identificador" => "aff0020" ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "<span class="elsevierStyleItalic">Stress</span> oxidativo e colesterol de lipoproteínas de alta densidade – causa ou consequência?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Atherosclerosis is a common underlying cause of cardiovascular disease (CVD). The American Heart Association reported that the prevalence of atherosclerosis is expected to increase by 18% by 2030.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> Dyslipidemia, characterized by high levels of lipids (cholesterol, triglycerides, or both), is one of the main risk factors for atherosclerosis.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a> However, a low level of high-density lipoprotein cholesterol (HDL-C) is considered an independent risk factor for CVD.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a> Low HDL-C levels are inversely associated with cardiovascular risk and are a critical risk factor for estimating the 10-year risk of CVD.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a> Nevertheless, the relevance of HDL-C as an independent CVD risk factor when other lipids are normal is unclear. The atheroprotective properties of HDL-C include its ability to mediate macrophage cholesterol efflux, antioxidant and anti-inflammatory properties, and nitric oxide promoting activity.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> However, HDL particles are complex and heterogeneous in composition and function, and HDL-C level may not be an independent modifiable and causal CVD-specific risk factor.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> Additionally, naturally or pharmacologically induced high HDL-C was not associated with reduced CVD risk.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3,5,6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">As mentioned, HDL-C has antioxidant properties. Oxidative stress is defined as an imbalance between antioxidant factors and the production of reactive oxygen species (ROS) in favor of the latter, which results in oxidative damage.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> Oxidative stress is thought to play a part in the pathogenesis of atherosclerosis, and HDL-C can potentially slow the development of atherosclerosis. Assessment of total antioxidant capacity (TAC) and total oxidant status (TOS) has been used to assess oxidant and antioxidant systems since, biologically, overall oxidant status may be more appropriate than the measurement of a single antioxidant. Moreover, the oxidative stress index (OSI), defined as the TOS/TAC ratio, as an indicator of oxidative stress, reflects the balance between oxidant and antioxidant agents.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">These oxidative stress parameters are studied by Karabacak et al. in an analysis published in this issue of the <span class="elsevierStyleItalic">Journal</span>.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> Their study aimed to analyze the favorable effects of HDL-C on the oxidative stress of patients with different HDL-C levels. The authors compared patients with low and high HDL-C and a group of matched controls with normal HDL-C, analyzing several oxidative stress parameters (TAC, TOS, OSI, total thiol levels, and arylesterase [ARES] activity). The authors reported that ARES activity and total thiol levels were significantly higher in patients with high HDL-C compared to those with low HDL-C. At the same time, TAC, TOS, OSI, uric acid, and gamma-glutamyltransferase were higher in low HDL-C patients.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Establishing connections between known risk factors is a promising tool for identifying important molecules or signatures to improve current clinical biomarkers used for risk assessment, stratification, and therapeutic approaches. The study by Karabacak et al.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> presents some limitations, which are acknowledged by the authors, the most important being the small sample size, single-center data, and a single time point of assessment. Overall, this paper contributes to knowledge improvement by showing a relationship between oxidative stress and low HDL-C, highlighting the correlation between these modifiable risk factors. A future follow-up study of these patients may help us to better understand the impact of the relationship between oxidative stress and low HDL-C and the role it plays as a risk factor for CVD.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0025" class="elsevierStylePara elsevierViewall">Supported by <span class="elsevierStyleGrantSponsor" id="gs1">CIMAGO</span> – Center of Investigation on Environment, Genetics and Oncobiology, Faculty of Medicine, University of Coimbra, Portugal, by <span class="elsevierStyleGrantSponsor" id="gs2">Fundação para a Ciência e a Tecnologia</span> (FCT), Portugal (Strategic Projects UID/NEU/04539/2013 and UID/NEU/04539/2019), and <span class="elsevierStyleGrantSponsor" id="gs3">COMPETE-FEDER</span> (<span class="elsevierStyleGrantNumber" refid="gs3">POCI-01-0145-FEDER-007440</span>).</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflicts of interest" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib0045" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Heart Disease and Stroke Statistics-2018 Update: a report from the American Heart Association" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E.J. 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Türkdogan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Port Cardiol" "fecha" => "2022" "volumen" => "41" "paginaInicial" => "833" "paginaFinal" => "839" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/08702551/0000004100000010/v1_202210061538/S0870255122002682/v1_202210061538/en/main.assets" "Apartado" => array:4 [ "identificador" => "92834" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/08702551/0000004100000010/v1_202210061538/S0870255122002682/v1_202210061538/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122002682?idApp=UINPBA00004E" ]
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