que se leu este artigo
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[ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 580 "Ancho" => 1258 "Tamanyo" => 29370 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Scatter plot showing Pearson's correlation between active atrial emptying fractions and contraction left atrial strain (r=0.674 and p<0.001).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Kamilla Leite Morbeck Teixeira, Edileide de Barros Correia, Cíntia Galhardo Tressino, Marcela Momesso Peçanha, Walter Antonio Melchior, Rodrigo Bellio de Mattos Barretto, Bruna Gomes de Medeiros, David Le Bihan" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Kamilla Leite Morbeck" "apellidos" => "Teixeira" ] 1 => array:2 [ "nombre" => "Edileide de Barros" "apellidos" => "Correia" ] 2 => array:2 [ "nombre" => "Cíntia Galhardo" "apellidos" => "Tressino" ] 3 => array:2 [ "nombre" => "Marcela Momesso" "apellidos" => "Peçanha" ] 4 => array:2 [ "nombre" => "Walter Antonio" "apellidos" => "Melchior" ] 5 => array:2 [ "nombre" => "Rodrigo Bellio de Mattos" "apellidos" => "Barretto" ] 6 => array:2 [ "nombre" => "Bruna Gomes de" "apellidos" => "Medeiros" ] 7 => array:2 [ "nombre" => "David" "apellidos" => "Le Bihan" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122002463?idApp=UINPBA00004E" "url" => "/08702551/0000004100000009/v1_202209010540/S0870255122002463/v1_202209010540/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0870255122002621" "issn" => "08702551" "doi" => "10.1016/j.repc.2021.07.013" "estado" => "S300" "fechaPublicacion" => "2022-09-01" "aid" => "1982" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2022;41:761-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Index of microcirculatory resistance in the assessment of coronary microvascular dysfunction in hypertrophic cardiomyopathy" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "761" "paginaFinal" => "767" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Índice de resistência microcirculatória na avaliação da disfunção microvascular coronária na miocardiopatia hipertrófica" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1165 "Ancho" => 1740 "Tamanyo" => 178426 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Index of microcirculatory resistance and evaluation of ischemia by coronary microvascular dysfunction in a hypertrophic cardiomyopathy patient. A-catheterization of left anterior descending artery coronary and hemodynamic parameters showed on the dedicated software: Distal coronary pressure (Pd)=66 mmHg, resting mean transit time (Bas)=95 ms, hyperemic mean transit time (Hyp)=32 ms, coronary flow reserve (CFR)=3.0. Calculated index of microcirculatory resistance (IMR) was 20.5 (not shown). B-CMR perfusion images with evidence of perfusion defect (arrow).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Sílvia Aguiar Rosa, Miguel Mota Carmo, Luís Rocha Lopes, Eunice Oliveira, Boban Thomas, Luis Baquero, Rui Cruz Ferreira, António Fiarresga" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Sílvia" "apellidos" => "Aguiar Rosa" ] 1 => array:2 [ "nombre" => "Miguel" "apellidos" => "Mota Carmo" ] 2 => array:2 [ "nombre" => "Luís" "apellidos" => "Rocha Lopes" ] 3 => array:2 [ "nombre" => "Eunice" "apellidos" => "Oliveira" ] 4 => array:2 [ "nombre" => "Boban" "apellidos" => "Thomas" ] 5 => array:2 [ "nombre" => "Luis" "apellidos" => "Baquero" ] 6 => array:2 [ "nombre" => "Rui" "apellidos" => "Cruz Ferreira" ] 7 => array:2 [ "nombre" => "António" "apellidos" => "Fiarresga" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122002621?idApp=UINPBA00004E" "url" => "/08702551/0000004100000009/v1_202209010540/S0870255122002621/v1_202209010540/en/main.assets" ] "asociados" => array:1 [ 0 => array:19 [ "pii" => "S0870255122002621" "issn" => "08702551" "doi" => "10.1016/j.repc.2021.07.013" "estado" => "S300" "fechaPublicacion" => "2022-09-01" "aid" => "1982" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2022;41:761-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Index of microcirculatory resistance in the assessment of coronary microvascular dysfunction in hypertrophic cardiomyopathy" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "761" "paginaFinal" => "767" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Índice de resistência microcirculatória na avaliação da disfunção microvascular coronária na miocardiopatia hipertrófica" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1165 "Ancho" => 1740 "Tamanyo" => 178426 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Index of microcirculatory resistance and evaluation of ischemia by coronary microvascular dysfunction in a hypertrophic cardiomyopathy patient. A-catheterization of left anterior descending artery coronary and hemodynamic parameters showed on the dedicated software: Distal coronary pressure (Pd)=66 mmHg, resting mean transit time (Bas)=95 ms, hyperemic mean transit time (Hyp)=32 ms, coronary flow reserve (CFR)=3.0. Calculated index of microcirculatory resistance (IMR) was 20.5 (not shown). B-CMR perfusion images with evidence of perfusion defect (arrow).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Sílvia Aguiar Rosa, Miguel Mota Carmo, Luís Rocha Lopes, Eunice Oliveira, Boban Thomas, Luis Baquero, Rui Cruz Ferreira, António Fiarresga" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Sílvia" "apellidos" => "Aguiar Rosa" ] 1 => array:2 [ "nombre" => "Miguel" "apellidos" => "Mota Carmo" ] 2 => array:2 [ "nombre" => "Luís" "apellidos" => "Rocha Lopes" ] 3 => array:2 [ "nombre" => "Eunice" "apellidos" => "Oliveira" ] 4 => array:2 [ "nombre" => "Boban" "apellidos" => "Thomas" ] 5 => array:2 [ "nombre" => "Luis" "apellidos" => "Baquero" ] 6 => array:2 [ "nombre" => "Rui" "apellidos" => "Cruz Ferreira" ] 7 => array:2 [ "nombre" => "António" "apellidos" => "Fiarresga" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122002621?idApp=UINPBA00004E" "url" => "/08702551/0000004100000009/v1_202209010540/S0870255122002621/v1_202209010540/en/main.assets" ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>" "titulo" => "Invasive versus non-invasive coronary microvascular assessment in hypertrophic myocardiopathy – Are we measuring the same thing?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "769" "paginaFinal" => "770" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Nuno Bettencourt" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Nuno" "apellidos" => "Bettencourt" "email" => array:1 [ 0 => "bettencourt.n@gmail.com" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Unidade de Investigação Cardiovascular – Faculdade de Medicina do Porto, Porto, Portugal" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Avaliação invasiva e não-invasiva da doença microvascular na miocardiopatia hipertrófica – Estaremos a medir a mesma coisa?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease inherited as an autosomal dominant trait. Its main characteristic is left ventricular hypertrophy that occurs in the absence of other conditions that trigger this change.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Disease penetrance and the age of phenotypic development range over generations; initial presentations may vary from asymptomatic forms found in routine echocardiography to manifestations of heart failure or sudden cardiac death.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> Despite having a low long-term mortality, the burden of morbidity in Portugal remains considerable. Age at diagnosis is relatively advanced, emphasizing both the need for better diagnostic strategies and better treatments targeting symptomatic control and the natural history of the disease.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Clinical scores have been developed to provide prognostic and functional assessments and to enable risk stratification.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> Additionally, high-resolution imaging methods, such as cardiac magnetic resonance (CMR), represent an important complement to echocardiography in different clinical scenarios.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> CMR is becoming increasingly used in HCM, especially for the identification of other important hallmarks of the disease: myocardial fibrosis (which is usually more prominent in the most hypertrophic segments) and coronary microvascular disfunction (CMD). Both these features have been proven to be directly linked to, but also to be independently associated with poor outcomes in HCM patients.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In this issue of the Journal, Rosa et al.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> present part of their research into CMD in patients with HCM, using both regadenoson stress-rest CMR and the invasive assessment of the index of microcirculatory resistance (IMR) during coronary catheterization. For the first time, IMR has been used for the assessment of CMD in HCM patients without epicardial coronary artery disease, adding an important contribution to the scientific knowledge in his field. Despite the inherent limitations associated with the number sample size, this pilot study has the advantage of the simultaneous use of two very different techniques (CMR and IMR) for the assessment of CMD. This approach enables a direct comparison of the findings and opens up an interesting discussion on how to correlate and interpret the results.</p><p id="par0025" class="elsevierStylePara elsevierViewall">As the authors correctly state, CMD is one of the less understood pathophysiological features of HCM. Several methods can be used for the assessment of CMD but there is no universal gold-standard and the different methods are probably measuring different markers of the same reality. Therefore, it is interesting to note that patients with abnormal IMR seemed to have more significant tissue abnormalities as defined by CMR, namely fibrosis and increased extracellular volume (as assessed by late gadolinium enhancement and T1-mapping). And, in my view, it is particularly exciting to interpret the somehow discordant results obtained with the two techniques. The concordance between IMR and CFR was found in only six patients (43%) and the prevalence of CMD by IMR was significantly lower than the detection of ischemia using stress CMR. The authors raise the hypothesis that lower IMR values may be found in HCM patients compared with other diseases, and postulate that HCM may run its course with a reduction in coronary flow reserve secondary to near maximal baseline vasodilation of the microcirculation, instead of an increase in coronary microvascular resistance due to a narrowing of small vessels or external compression. This type of CMD would be detected using CMR, which is sensible for myocardial perfusion flow reserve, but not for IMR, since microvascular resistance would not be significantly. Another interesting point is that CMR is able to simultaneously assess the cumulative global impact of CMD in the whole myocardium, while IMR and the other invasive techniques such as coronary flow reserve measurement have the advantage of being vessel-specific but may lose some sensitivity in a global microvascular tree assessment.</p><p id="par0030" class="elsevierStylePara elsevierViewall">As good research often does, this study raises more questions than it gives answers. Nevertheless, it is another piece of a puzzle that is far from being complete and invites us to conduct further research into the potential of IMR and the value of CMD assessment in patients with HCM. We will be sitting on the front row to see what this approach may bring to the management of these patients, especially for the diagnosis, symptom control and prognosis-modifying treatment.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2020 AHA/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.R. Ommen" 1 => "S. Mital" 2 => "M.A. Burke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2020" "volumen" => "142" "paginaInicial" => "e533" "paginaFinal" => "e557" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0040" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypertrophic cardiomyopathy: a review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.G.Z. Bazan" 1 => "G.O. Oliveira" 2 => "C.F.S.M.P. Silveira" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.36660/abc.20190802" "Revista" => array:6 [ "tituloSerie" => "Arq Bras Cardiol" "fecha" => "2020" "volumen" => "115" "paginaInicial" => "927" "paginaFinal" => "935" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33295458" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0045" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Portuguese Registry of Hypertrophic Cardiomyopathy: overall results" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N. Cardim" 1 => "D. Brito" 2 => "L.R. Lopes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Port Cardiol (Engl Ed)" "fecha" => "2018" "volumen" => "37" "paginaInicial" => "1" "paginaFinal" => "10" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0050" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Documento de Consenso sobre Estratificação de Risco Cardiovascular e estudo da doença coronária em Portugal: a posição dos Grupos de Estudo de Cardiologia Nuclear, Ressonância Magnética e Tomografia Computorizada Cardíaca, de Ecocardiografia e de Fisiopatologia do Esforço e Reabilitação Cardíaca" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N. Bettencourt" 1 => "L. Mendes" 2 => "J.P. Fontes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.repc.2020.10.009" "Revista" => array:3 [ "tituloSerie" => "Rev Port Cardiol" "fecha" => "2021" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2631811" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0055" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microvascular ischemia in hypertrophic cardiomyopathy: new insights from high-resolution combined quantification of perfusion and late gadolinium enhancement" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.D. Vila" 1 => "E. Sammut" 2 => "N. Zarinabad" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s12968-016-0223-8" "Revista" => array:5 [ "tituloSerie" => "J Cardiovasc Magn Reson" "fecha" => "2016" "volumen" => "18" "paginaInicial" => "4" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26767610" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0060" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Index of microcirculatory resistance in the assessment of coronary microvascular dysfunction in hypertrophic cardiomyopathy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.A. Rosa" 1 => "M.M. Carmo" 2 => "L.R. Lopes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Port Cardiol." "fecha" => "2022" "volumen" => "41" "paginaInicial" => "761" "paginaFinal" => "767" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/08702551/0000004100000009/v1_202209010540/S0870255122002657/v1_202209010540/en/main.assets" "Apartado" => array:4 [ "identificador" => "92834" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/08702551/0000004100000009/v1_202209010540/S0870255122002657/v1_202209010540/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122002657?idApp=UINPBA00004E" ]
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