array:23 [
  "pii" => "S0870255122000348"
  "issn" => "08702551"
  "doi" => "10.1016/j.repc.2021.08.005"
  "estado" => "S300"
  "fechaPublicacion" => "2022-07-01"
  "aid" => "1902"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2022"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "cor"
  "cita" => "Rev Port Cardiol. 2022;41:609-10"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0870255122002426"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2021.08.014"
    "estado" => "S300"
    "fechaPublicacion" => "2022-07-01"
    "aid" => "1968"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Rev Port Cardiol. 2022;41:605-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Image in Cardiology</span>"
      "titulo" => "Self-limited massive hematemesis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "605"
          "paginaFinal" => "607"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Hematemeses maci&#231;as autolimitadas"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2002
              "Ancho" => 2007
              "Tamanyo" => 450578
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#46; Endoscopy of the upper gastrointestinal tract&#44; revealing the presence of blood clot at the proximal esophageal tract &#40;red arrow&#41; with erosion from a pulsative mass&#46; B&#46; Computed tomography angiography of aorta and thorax with intravenous contrast agent&#44; axial view&#44; depicting the presence of a saccular descending aortic aneurysm at the level of the tracheal carina&#44; with mural thrombus &#40;red arrow&#41;&#44; and an aortoesophageal fistula blocked by a part of the thrombus&#44; protruding into the esophagus lumen &#40;yellow arrow&#41;&#46; C&#46; Computed tomography angiography of aorta and thorax&#44; three dimensional reconstruction&#44; depicting the presence of the descending aortic aneurysm&#46; D&#46; Computed tomography angiography of aorta and thorax with intravenous contrast agent&#44; axial view&#44; depicting the presence of a saccular descending aortic aneurysm at the level of the tracheal carina with the presence of air within the thrombus&#39;s layers &#40;red arrows&#41;&#46; E&#46; Computed tomography angiography of aorta and thorax with intravenous contrast agent&#44; sagittal view&#44; depicting the aneurysm&#39;s mural thrombus &#40;red arrow&#41;&#44; protruding into the esophagus lumen &#40;yellow arrow&#41;&#46; F&#46; Invasive angiography&#44; showing the result of the thoracic endovascular aortic repair procedure with coverage of the aneurysm with endovascular stent graft &#40;red arrow&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Dimitrios Afendoulis, Athanasios Kartalis, Nikolaos Papagiannis, Maria Moutafi, Petros Voutas, Ioannis Gklotsos, Dimitrios Siskos, Aristodimos Maratsos, Konstantinos Toutouzas"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "Dimitrios"
              "apellidos" => "Afendoulis"
            ]
            1 => array:2 [
              "nombre" => "Athanasios"
              "apellidos" => "Kartalis"
            ]
            2 => array:2 [
              "nombre" => "Nikolaos"
              "apellidos" => "Papagiannis"
            ]
            3 => array:2 [
              "nombre" => "Maria"
              "apellidos" => "Moutafi"
            ]
            4 => array:2 [
              "nombre" => "Petros"
              "apellidos" => "Voutas"
            ]
            5 => array:2 [
              "nombre" => "Ioannis"
              "apellidos" => "Gklotsos"
            ]
            6 => array:2 [
              "nombre" => "Dimitrios"
              "apellidos" => "Siskos"
            ]
            7 => array:2 [
              "nombre" => "Aristodimos"
              "apellidos" => "Maratsos"
            ]
            8 => array:2 [
              "nombre" => "Konstantinos"
              "apellidos" => "Toutouzas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122002426?idApp=UINPBA00004E"
    "url" => "/08702551/0000004100000007/v1_202207030541/S0870255122002426/v1_202207030541/en/main.assets"
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Kawasaki disease&#58; Specific considerations in the management of coronary artery sequelae"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "609"
        "paginaFinal" => "610"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Kenan Yalta, Ugur Ozkan, Tulin Yalta, Ertan Yetk&#305;n"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Kenan"
            "apellidos" => "Yalta"
            "email" => array:1 [
              0 => "kyalta@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Ugur"
            "apellidos" => "Ozkan"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Tulin"
            "apellidos" => "Yalta"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Ertan"
            "apellidos" => "Yetk&#305;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Trakya University&#44; Cardiology Department&#44; Edirne&#44; Turkey"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Trakya University&#44; Pathology Department&#44; Edirne&#44; Turkey"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Derindere Hospital&#44; Cardiology Department&#44; Istanbul&#44; Turkey"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Doen&#231;a de Kawasaki&#58; Considera&#231;&#245;es espec&#237;ficas no tratamento de sequelas nas art&#233;rias coron&#225;rias"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Kawasaki disease &#40;KD&#41; is widely regarded as an acute autoinflammatory condition in children presenting with high-grade and persistent fever&#44; in association with a variety of multi-organ manifestations&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;3</span></a> Of note&#44; coronary arteritis has been the most dangerous manifestation&#44; mainly due to its potential association with subsequent complications&#44; including coronary artery aneurysms &#40;CAAs&#41; and stenoses&#44; which have long-term clinical implications&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;3</span></a> In their recently published article&#44; Magro et al&#46; &#40;1&#41; described a case of KD complicated by giant CAAs and critical left anterior descending &#40;LAD&#41; artery stenosis&#44; managed with coronary artery bypass grafting &#40;CABG&#41;&#46; In this context&#44; we would like to comment on this interesting case together with a couple of specific considerations in the management of emerging coronary sequelae associated with KD&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">First&#44; evolution of coronary artery stenosis has been mechanistically ascribed to the process of luminal myofibroblastic proliferation&#44; which also accounts for CAA regression in a large portion of patients with KD&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> In other terms&#44; gradual reduction in luminal CAA diameter generally comes at the cost of progressive stenotic lesions surrounding the CAAs&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> Consistent with this&#44; temporal regression of the LAD artery aneurysm &#40;during a period of about two and a half years&#41; seems to be associated with the emergence of a severely stenotic lesion just distal to the aneurysm in the patient&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Importantly&#44; success of percutaneous coronary interventions &#40;PCIs&#41; might be relatively low in the management of these stenotic lesions due to their challenging morphological features &#40;highly fibroproliferative and&#47;or calcified&#41; and specific predilection sites &#40;mostly located at the proximal or distal part of the CAAs and potentially leading to stent malapposition&#44; etc&#46;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;2&#44;4</span></a> Therefore&#44; CABG in the present case appears to be a reasonable strategy at first glance&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">However&#44; coronary stenotic lesions can also arise due to a classical atheroma formation as a consequence of endothelial dysfunction<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> associated with the impact of generalized vascular inflammation and disturbed rheological kinetics &#40;including slow and turbulent flow associated with the aneurysmal sac&#40;s&#41;&#41; along the coronary arteries in certain KD cases&#46; Interestingly&#44; these lesions can be relatively soft in nature&#44; and can also be located distant from the co-existing CAAs &#40;as may have also arisen in the present case<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> the long-term&#41;&#44; potentially rendering them more amenable to PCIs&#46; Therefore&#44; identification of plaque morphology with the guidance of certain imaging modalities &#40;intravascular ultrasound&#44; optic coherence tomography&#44; etc&#46;&#41; may help determine the subsequent management strategy &#40;CABG&#44; PCI&#44; rotational atherectomy&#44; etc&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;4</span></a>&#41;&#46; Accordingly&#44; we wonder whether the authors considered these imaging modalities before CABG&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Second&#44; CAA evolution following KD episodes has been a more recognized phenomenon and is generally attributed to acute multi-layer necrotizing vasculitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;2&#44;4</span></a> In this setting&#44; CAAs&#44; if present&#44; generally reach their maximum diameter around six weeks after the onset of KD&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> Established CAAs have been universally managed with antiaggregant or anticoagulant medications &#40;or both&#41; together with certain antiatherogenic drugs in the setting of KD&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> On the other hand&#44; most complications including fistula formation&#44; rupture&#44; recurrent coronary ischemic events etc&#46; generally take place in the setting of giant CAAs&#44; characterized by a diameter of &#62;8 mm or a Z score of &#8805;10&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;5</span></a> Accordingly&#44; even though the CAAs in the patient<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> might be regarded as giant ones based on their aneurysmal diameters&#44; we wonder about the values of more objective parameters including Z score&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In terms of radical management&#44; it is highly recommended that persistently large CAAs &#40;whether stable or progressively expanding&#41; be treated with elective operations including aneurysmectomy&#44; graft stents or coil embolization etc&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> even if they are totally asymptomatic under optimal medical therapy&#46; Moreover&#44; indication for excision of giant CAAs seems to be even stronger during elective cardiac operations performed for concomitant pathologies including valve disease&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> coronary stenosis &#40;as in the present case<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a>&#41;&#46; Therefore&#44; we wonder why the surgeons exclusively performed CABG&#44; and left the giant CAAs surgically untreated&#46; Performing a more radical operation could have solved the problem in a single attempt&#46; Was there a technical failure or an anatomical obstacle &#40;including involvement of the diagonal branch by the aneurysmal sac&#44; etc&#46;&#41; potentially hampering excision or modification of CAAs&#63; Unfortunately&#44; the patient may still experience recurrent coronary ischemic events &#40;due to coronary embolization&#44; compression on the left internal mammary artery graft by the expanding CAA&#44; etc&#46;&#41; and serious mechanical complications &#40;CAA rupture&#44; fistula formation&#41; potentially requiring re-operation in the long-term&#46; On the other hand&#44; we also are of the opinion that certain giant CAAs with a clear-cut temporal regression might be watchfully monitored under optimal medical therapy&#46; Accordingly&#44; we wonder about the initial dimensions of the giant CAAs in the patient &#40;the values around six weeks after KD onset when the patient&#39;s CAAs were supposed to have maximum diameters&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Were the giant CAAs progressive&#44; regressive or stable in time according to the Z score values&#63; Based on temporal changes in CAA diameters&#44; CAA involving the LAD artery seems to have a regressive nature as opposed to the CAA of the right coronary artery with a potential tendency to expand in time&#46; We also wonder whether the authors would consider renin-angiotensin system blockade &#40;particularly with captopril&#41; that might have a favorable impact on CAA progression&#44; largely through the inhibition of certain key mediators of arterial remodeling&#44; including matrix metalloproteinases&#63;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Finally&#44; this case report clearly supports the strong association between the evolution of coronary sequelae and the failure to administer disease-modifying agents &#40;intravenous immunoglobulin &#40;IVIG&#41;&#44; etc&#46;&#41; in a timely manner in the setting of acute KD episodes&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;4</span></a> This also suggests there is a need to further heighten clinical awareness of KD symptoms among parents<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> and even clinicians for the prevention of these potentially fatal sequelae&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In summary&#44; Magro et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> should be congratulated for their didactic article&#46; In the setting of KD&#44; management of coronary sequelae primarily need to be individualized according to patient characteristics&#46; In KD patients undergoing cardiac surgery&#44; management of all the existing coronary sequelae at a single time &#40;where applicable&#41; appears to be a reasonable strategy in clinical practice&#46; Nevertheless&#44; prevention of these sequelae with the timely initiation of disease-modifying agents should still be regarded as the primary goal in KD management&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Coronary artery bypass grafting in a child with Kawasaki disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46; Magro"
                            1 => "N&#46; Carvalho"
                            2 => "R&#46; Anjos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Rev Port Cardiol &#40;Engl Ed&#41;"
                        "fecha" => "2021"
                        "volumen" => "40"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Late coronary aneurysm formation after kawasaki disease&#58; a review of mechanistic and clinical aspects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Yalta"
                            1 => "T&#46; Yalta"
                            2 => "E&#46; Yetkin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Korean Circ J"
                        "fecha" => "2021"
                        "volumen" => "51"
                        "paginaInicial" => "e99"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "American heart association rheumatic fever&#44; endocarditis&#44; and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young&#59; Council on Cardiovascular and Stroke Nursing&#59; Council on Cardiovascular Surgery and Anesthesia&#59; and Council on Epidemiology and Prevention Diagnosis&#44; Treatment&#44; and Long-Term Management of Kawasaki Disease&#58; a scientific statement for health professionals from the American Heart Association"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46;W&#46; McCrindle"
                            1 => "A&#46;H&#46; Rowley"
                            2 => "J&#46;W&#46; Newburger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIR.0000000000000484"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2017"
                        "volumen" => "135"
                        "paginaInicial" => "e927"
                        "paginaFinal" => "e999"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28356445"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lifetime cardiovascular management of patients with previous Kawasaki disease"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Kawasaki Disease Writing Group&#44; on behalf of the Royal College of Paediatrics and Child Health&#44; and the British Cardiovascular Society"
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46; Brogan"
                            1 => "J&#46;C&#46; Burns"
                            2 => "J&#46; Cornish"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/heartjnl-2019-315925"
                      "Revista" => array:6 [
                        "tituloSerie" => "Heart"
                        "fecha" => "2020"
                        "volumen" => "106"
                        "paginaInicial" => "411"
                        "paginaFinal" => "420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31843876"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fistulous coronary artery aneurysms&#58; further insights into mechanistic and clinical implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Yalta"
                            1 => "C&#46; Ozturk"
                            2 => "T&#46; Yalta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Port Cardiol &#40;Eng Ed&#41;"
                        "fecha" => "2021"
                        "volumen" => "40"
                        "paginaInicial" => "989"
                        "paginaFinal" => "990"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Late coronary aneurysm formation in Kawasaki disease&#58; a subtle phenomenon with potential implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46; Yalta"
                            1 => "M&#46; Gurdogan"
                            2 => "G&#46; Taylan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Heart eLetters"
                        "fecha" => "2019"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;heart&#46;bmj&#46;com"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/08702551/0000004100000007/v1_202207030541/S0870255122000348/v1_202207030541/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "93061"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letter to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08702551/0000004100000007/v1_202207030541/S0870255122000348/v1_202207030541/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122000348?idApp=UINPBA00004E"
]
Partilhar
Informação da revista

Estatísticas

Siga este link para acessar o texto completo do artigo

Letter to the Editor
Kawasaki disease: Specific considerations in the management of coronary artery sequelae
Doença de Kawasaki: Considerações específicas no tratamento de sequelas nas artérias coronárias
Kenan Yaltaa,
Autor para correspondência
kyalta@gmail.com

Corresponding author.
, Ugur Ozkana, Tulin Yaltab, Ertan Yetkınc
a Trakya University, Cardiology Department, Edirne, Turkey
b Trakya University, Pathology Department, Edirne, Turkey
c Derindere Hospital, Cardiology Department, Istanbul, Turkey
Lido
2239
Vezes
que se leu este artigo
931
Total PDF
1308
Total HTML
Compartilhar estatísticas
 array:23 [
  "pii" => "S0870255122000348"
  "issn" => "08702551"
  "doi" => "10.1016/j.repc.2021.08.005"
  "estado" => "S300"
  "fechaPublicacion" => "2022-07-01"
  "aid" => "1902"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2022"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "cor"
  "cita" => "Rev Port Cardiol. 2022;41:609-10"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0870255122002426"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2021.08.014"
    "estado" => "S300"
    "fechaPublicacion" => "2022-07-01"
    "aid" => "1968"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Rev Port Cardiol. 2022;41:605-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Image in Cardiology</span>"
      "titulo" => "Self-limited massive hematemesis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "605"
          "paginaFinal" => "607"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Hematemeses maci&#231;as autolimitadas"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2002
              "Ancho" => 2007
              "Tamanyo" => 450578
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#46; Endoscopy of the upper gastrointestinal tract&#44; revealing the presence of blood clot at the proximal esophageal tract &#40;red arrow&#41; with erosion from a pulsative mass&#46; B&#46; Computed tomography angiography of aorta and thorax with intravenous contrast agent&#44; axial view&#44; depicting the presence of a saccular descending aortic aneurysm at the level of the tracheal carina&#44; with mural thrombus &#40;red arrow&#41;&#44; and an aortoesophageal fistula blocked by a part of the thrombus&#44; protruding into the esophagus lumen &#40;yellow arrow&#41;&#46; C&#46; Computed tomography angiography of aorta and thorax&#44; three dimensional reconstruction&#44; depicting the presence of the descending aortic aneurysm&#46; D&#46; Computed tomography angiography of aorta and thorax with intravenous contrast agent&#44; axial view&#44; depicting the presence of a saccular descending aortic aneurysm at the level of the tracheal carina with the presence of air within the thrombus&#39;s layers &#40;red arrows&#41;&#46; E&#46; Computed tomography angiography of aorta and thorax with intravenous contrast agent&#44; sagittal view&#44; depicting the aneurysm&#39;s mural thrombus &#40;red arrow&#41;&#44; protruding into the esophagus lumen &#40;yellow arrow&#41;&#46; F&#46; Invasive angiography&#44; showing the result of the thoracic endovascular aortic repair procedure with coverage of the aneurysm with endovascular stent graft &#40;red arrow&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Dimitrios Afendoulis, Athanasios Kartalis, Nikolaos Papagiannis, Maria Moutafi, Petros Voutas, Ioannis Gklotsos, Dimitrios Siskos, Aristodimos Maratsos, Konstantinos Toutouzas"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "Dimitrios"
              "apellidos" => "Afendoulis"
            ]
            1 => array:2 [
              "nombre" => "Athanasios"
              "apellidos" => "Kartalis"
            ]
            2 => array:2 [
              "nombre" => "Nikolaos"
              "apellidos" => "Papagiannis"
            ]
            3 => array:2 [
              "nombre" => "Maria"
              "apellidos" => "Moutafi"
            ]
            4 => array:2 [
              "nombre" => "Petros"
              "apellidos" => "Voutas"
            ]
            5 => array:2 [
              "nombre" => "Ioannis"
              "apellidos" => "Gklotsos"
            ]
            6 => array:2 [
              "nombre" => "Dimitrios"
              "apellidos" => "Siskos"
            ]
            7 => array:2 [
              "nombre" => "Aristodimos"
              "apellidos" => "Maratsos"
            ]
            8 => array:2 [
              "nombre" => "Konstantinos"
              "apellidos" => "Toutouzas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122002426?idApp=UINPBA00004E"
    "url" => "/08702551/0000004100000007/v1_202207030541/S0870255122002426/v1_202207030541/en/main.assets"
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Kawasaki disease&#58; Specific considerations in the management of coronary artery sequelae"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "609"
        "paginaFinal" => "610"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Kenan Yalta, Ugur Ozkan, Tulin Yalta, Ertan Yetk&#305;n"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Kenan"
            "apellidos" => "Yalta"
            "email" => array:1 [
              0 => "kyalta@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Ugur"
            "apellidos" => "Ozkan"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Tulin"
            "apellidos" => "Yalta"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Ertan"
            "apellidos" => "Yetk&#305;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Trakya University&#44; Cardiology Department&#44; Edirne&#44; Turkey"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Trakya University&#44; Pathology Department&#44; Edirne&#44; Turkey"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Derindere Hospital&#44; Cardiology Department&#44; Istanbul&#44; Turkey"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Doen&#231;a de Kawasaki&#58; Considera&#231;&#245;es espec&#237;ficas no tratamento de sequelas nas art&#233;rias coron&#225;rias"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Kawasaki disease &#40;KD&#41; is widely regarded as an acute autoinflammatory condition in children presenting with high-grade and persistent fever&#44; in association with a variety of multi-organ manifestations&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;3</span></a> Of note&#44; coronary arteritis has been the most dangerous manifestation&#44; mainly due to its potential association with subsequent complications&#44; including coronary artery aneurysms &#40;CAAs&#41; and stenoses&#44; which have long-term clinical implications&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;3</span></a> In their recently published article&#44; Magro et al&#46; &#40;1&#41; described a case of KD complicated by giant CAAs and critical left anterior descending &#40;LAD&#41; artery stenosis&#44; managed with coronary artery bypass grafting &#40;CABG&#41;&#46; In this context&#44; we would like to comment on this interesting case together with a couple of specific considerations in the management of emerging coronary sequelae associated with KD&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">First&#44; evolution of coronary artery stenosis has been mechanistically ascribed to the process of luminal myofibroblastic proliferation&#44; which also accounts for CAA regression in a large portion of patients with KD&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> In other terms&#44; gradual reduction in luminal CAA diameter generally comes at the cost of progressive stenotic lesions surrounding the CAAs&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> Consistent with this&#44; temporal regression of the LAD artery aneurysm &#40;during a period of about two and a half years&#41; seems to be associated with the emergence of a severely stenotic lesion just distal to the aneurysm in the patient&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Importantly&#44; success of percutaneous coronary interventions &#40;PCIs&#41; might be relatively low in the management of these stenotic lesions due to their challenging morphological features &#40;highly fibroproliferative and&#47;or calcified&#41; and specific predilection sites &#40;mostly located at the proximal or distal part of the CAAs and potentially leading to stent malapposition&#44; etc&#46;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;2&#44;4</span></a> Therefore&#44; CABG in the present case appears to be a reasonable strategy at first glance&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">However&#44; coronary stenotic lesions can also arise due to a classical atheroma formation as a consequence of endothelial dysfunction<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> associated with the impact of generalized vascular inflammation and disturbed rheological kinetics &#40;including slow and turbulent flow associated with the aneurysmal sac&#40;s&#41;&#41; along the coronary arteries in certain KD cases&#46; Interestingly&#44; these lesions can be relatively soft in nature&#44; and can also be located distant from the co-existing CAAs &#40;as may have also arisen in the present case<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> the long-term&#41;&#44; potentially rendering them more amenable to PCIs&#46; Therefore&#44; identification of plaque morphology with the guidance of certain imaging modalities &#40;intravascular ultrasound&#44; optic coherence tomography&#44; etc&#46;&#41; may help determine the subsequent management strategy &#40;CABG&#44; PCI&#44; rotational atherectomy&#44; etc&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;4</span></a>&#41;&#46; Accordingly&#44; we wonder whether the authors considered these imaging modalities before CABG&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Second&#44; CAA evolution following KD episodes has been a more recognized phenomenon and is generally attributed to acute multi-layer necrotizing vasculitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;2&#44;4</span></a> In this setting&#44; CAAs&#44; if present&#44; generally reach their maximum diameter around six weeks after the onset of KD&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> Established CAAs have been universally managed with antiaggregant or anticoagulant medications &#40;or both&#41; together with certain antiatherogenic drugs in the setting of KD&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> On the other hand&#44; most complications including fistula formation&#44; rupture&#44; recurrent coronary ischemic events etc&#46; generally take place in the setting of giant CAAs&#44; characterized by a diameter of &#62;8 mm or a Z score of &#8805;10&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;5</span></a> Accordingly&#44; even though the CAAs in the patient<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> might be regarded as giant ones based on their aneurysmal diameters&#44; we wonder about the values of more objective parameters including Z score&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In terms of radical management&#44; it is highly recommended that persistently large CAAs &#40;whether stable or progressively expanding&#41; be treated with elective operations including aneurysmectomy&#44; graft stents or coil embolization etc&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> even if they are totally asymptomatic under optimal medical therapy&#46; Moreover&#44; indication for excision of giant CAAs seems to be even stronger during elective cardiac operations performed for concomitant pathologies including valve disease&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> coronary stenosis &#40;as in the present case<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a>&#41;&#46; Therefore&#44; we wonder why the surgeons exclusively performed CABG&#44; and left the giant CAAs surgically untreated&#46; Performing a more radical operation could have solved the problem in a single attempt&#46; Was there a technical failure or an anatomical obstacle &#40;including involvement of the diagonal branch by the aneurysmal sac&#44; etc&#46;&#41; potentially hampering excision or modification of CAAs&#63; Unfortunately&#44; the patient may still experience recurrent coronary ischemic events &#40;due to coronary embolization&#44; compression on the left internal mammary artery graft by the expanding CAA&#44; etc&#46;&#41; and serious mechanical complications &#40;CAA rupture&#44; fistula formation&#41; potentially requiring re-operation in the long-term&#46; On the other hand&#44; we also are of the opinion that certain giant CAAs with a clear-cut temporal regression might be watchfully monitored under optimal medical therapy&#46; Accordingly&#44; we wonder about the initial dimensions of the giant CAAs in the patient &#40;the values around six weeks after KD onset when the patient&#39;s CAAs were supposed to have maximum diameters&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Were the giant CAAs progressive&#44; regressive or stable in time according to the Z score values&#63; Based on temporal changes in CAA diameters&#44; CAA involving the LAD artery seems to have a regressive nature as opposed to the CAA of the right coronary artery with a potential tendency to expand in time&#46; We also wonder whether the authors would consider renin-angiotensin system blockade &#40;particularly with captopril&#41; that might have a favorable impact on CAA progression&#44; largely through the inhibition of certain key mediators of arterial remodeling&#44; including matrix metalloproteinases&#63;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Finally&#44; this case report clearly supports the strong association between the evolution of coronary sequelae and the failure to administer disease-modifying agents &#40;intravenous immunoglobulin &#40;IVIG&#41;&#44; etc&#46;&#41; in a timely manner in the setting of acute KD episodes&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;4</span></a> This also suggests there is a need to further heighten clinical awareness of KD symptoms among parents<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> and even clinicians for the prevention of these potentially fatal sequelae&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In summary&#44; Magro et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> should be congratulated for their didactic article&#46; In the setting of KD&#44; management of coronary sequelae primarily need to be individualized according to patient characteristics&#46; In KD patients undergoing cardiac surgery&#44; management of all the existing coronary sequelae at a single time &#40;where applicable&#41; appears to be a reasonable strategy in clinical practice&#46; Nevertheless&#44; prevention of these sequelae with the timely initiation of disease-modifying agents should still be regarded as the primary goal in KD management&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Coronary artery bypass grafting in a child with Kawasaki disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46; Magro"
                            1 => "N&#46; Carvalho"
                            2 => "R&#46; Anjos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Rev Port Cardiol &#40;Engl Ed&#41;"
                        "fecha" => "2021"
                        "volumen" => "40"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Late coronary aneurysm formation after kawasaki disease&#58; a review of mechanistic and clinical aspects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Yalta"
                            1 => "T&#46; Yalta"
                            2 => "E&#46; Yetkin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Korean Circ J"
                        "fecha" => "2021"
                        "volumen" => "51"
                        "paginaInicial" => "e99"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "American heart association rheumatic fever&#44; endocarditis&#44; and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young&#59; Council on Cardiovascular and Stroke Nursing&#59; Council on Cardiovascular Surgery and Anesthesia&#59; and Council on Epidemiology and Prevention Diagnosis&#44; Treatment&#44; and Long-Term Management of Kawasaki Disease&#58; a scientific statement for health professionals from the American Heart Association"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46;W&#46; McCrindle"
                            1 => "A&#46;H&#46; Rowley"
                            2 => "J&#46;W&#46; Newburger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIR.0000000000000484"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2017"
                        "volumen" => "135"
                        "paginaInicial" => "e927"
                        "paginaFinal" => "e999"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28356445"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lifetime cardiovascular management of patients with previous Kawasaki disease"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Kawasaki Disease Writing Group&#44; on behalf of the Royal College of Paediatrics and Child Health&#44; and the British Cardiovascular Society"
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46; Brogan"
                            1 => "J&#46;C&#46; Burns"
                            2 => "J&#46; Cornish"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/heartjnl-2019-315925"
                      "Revista" => array:6 [
                        "tituloSerie" => "Heart"
                        "fecha" => "2020"
                        "volumen" => "106"
                        "paginaInicial" => "411"
                        "paginaFinal" => "420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31843876"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fistulous coronary artery aneurysms&#58; further insights into mechanistic and clinical implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Yalta"
                            1 => "C&#46; Ozturk"
                            2 => "T&#46; Yalta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Port Cardiol &#40;Eng Ed&#41;"
                        "fecha" => "2021"
                        "volumen" => "40"
                        "paginaInicial" => "989"
                        "paginaFinal" => "990"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Late coronary aneurysm formation in Kawasaki disease&#58; a subtle phenomenon with potential implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46; Yalta"
                            1 => "M&#46; Gurdogan"
                            2 => "G&#46; Taylan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Heart eLetters"
                        "fecha" => "2019"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;heart&#46;bmj&#46;com"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/08702551/0000004100000007/v1_202207030541/S0870255122000348/v1_202207030541/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "93061"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letter to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08702551/0000004100000007/v1_202207030541/S0870255122000348/v1_202207030541/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255122000348?idApp=UINPBA00004E"
]
Informação do artigo
ISSN: 08702551
Idioma original: Inglês
Dados atualizados diariamente
Ano/Mês Html Pdf Total
2024 Novembro 4 5 9
2024 Outubro 58 40 98
2024 Setembro 53 22 75
2024 Agosto 74 43 117
2024 Julho 49 37 86
2024 Junho 55 29 84
2024 Maio 28 10 38
2024 Abril 45 33 78
2024 Maro 41 20 61
2024 Fevereiro 30 23 53
2024 Janeiro 34 28 62
2023 Dezembro 20 21 41
2023 Novembro 43 38 81
2023 Outubro 38 26 64
2023 Setembro 21 29 50
2023 Agosto 20 12 32
2023 Julho 27 14 41
2023 Junho 27 11 38
2023 Maio 27 28 55
2023 Abril 20 19 39
2023 Maro 34 23 57
2023 Fevereiro 29 15 44
2023 Janeiro 20 18 38
2022 Dezembro 32 19 51
2022 Novembro 43 30 73
2022 Outubro 38 33 71
2022 Setembro 30 33 63
2022 Agosto 53 48 101
2022 Julho 108 88 196
2022 Junho 74 43 117
2022 Maio 63 30 93
2022 Abril 48 40 88
2022 Maro 22 23 45
Mostrar tudo

Siga este link para acessar o texto completo do artigo

Idiomas
Revista Portuguesa de Cardiologia
en pt

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

Ao assinalar que é «Profissional de Saúde», declara conhecer e aceitar que a responsável pelo tratamento dos dados pessoais dos utilizadores da página de internet da Revista Portuguesa de Cardiologia (RPC), é esta entidade, com sede no Campo Grande, n.º 28, 13.º, 1700-093 Lisboa, com os telefones 217 970 685 e 217 817 630, fax 217 931 095 e com o endereço de correio eletrónico revista@spc.pt. Declaro para todos os fins, que assumo inteira responsabilidade pela veracidade e exatidão da afirmação aqui fornecida.