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The pulmonary veins are important triggers for AF&#44; and a number of electrophysiological &#40;e&#46;g&#46; reduced IK1 and ICa-L currents&#41; and anatomical &#40;branching fibers with limited lateral coupling and abrupt fiber orientation change&#41; features predispose the pulmonary veins to ectopy&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> This has led to electrical isolation of the pulmonary veins being the cornerstone of AF ablation&#46; However&#44; the triggers are only part of the story&#44; and remodeling of the atrial substrate is equally&#44; if not more&#44; important&#46; The atrial substrate undergoes a series of adverse remodeling changes&#44; including upregulation of potassium channels leading to a reduction in action potential duration&#44; increased fibrosis and a reduction in gap junction coupling&#46; These abnormalities of conduction and refractoriness all promote re-entry&#44; and thus the maintenance of AF&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">An often neglected aspect of AF pathophysiology is the potential role played by inflammation and oxidative stress in creating the electrical and structural remodeling that predisposes to AF&#46; Inflammatory markers have been shown to be increased in patients with AF&#46; Furthermore&#44; in chronic inflammatory conditions such as rheumatoid arthritis&#44; there are approximately 1&#46;5- and 2&#46;0-fold increases in atrial arrhythmias and sudden cardiac death&#44; respectively&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">4</span></a> This is because inflammatory cytokines&#44; such as interleukin &#40;IL&#41;-1&#44; IL-6 and tumor necrosis factor alpha&#44; increase fibrosis by causing cardiac fibroblasts to proliferate&#44; promoting differentiation to myofibroblasts&#44; and increasing collagen deposition&#46; They also modulate the activity of a number of ion currents&#44; for example reducing the transient outward current &#40;Ito&#41; and both components of the delayed rectifier potassium current &#40;IKs and Ikr&#41; to reduce refractoriness&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">5</span></a> all of which combine to promote arrhythmogenesis&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Oxidative stress&#44; which is increased in inflammation&#44; is also thought to play an important role in AF&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">6</span></a> Increased reactive oxygen species &#40;ROS&#41;&#44; more specifically&#44; increased nicotinamide adenine dinucleotide phosphate oxidase &#40;NOX&#41; and endothelial nitric oxide synthase activity&#44; have been demonstrated in patients with AF&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">7</span></a> Increased NOX can promote fibrosis through stimulation of transforming growth factor beta&#44; which then increases atrial arrhythmogenesis&#46; Furthermore&#44; ROS signaling has also been shown to modulate both ion channel function and calcium-induced calcium release&#44; both directly and via second messenger systems&#46; However&#44; despite evidence linking oxidative stress with AF&#44; antioxidant therapy has not been shown to reduce AF in clinical trials&#46; This may be because existing antioxidant therapies are not sufficiently targeting the key oxidative stress pathways&#46; Another possible reason is that increased oxidative stress is merely associated with AF&#44; and is a general marker for atrial myopathy&#44; but does not play a key role in AF pathogenesis&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In this issue of the <span class="elsevierStyleItalic">Journal</span>&#44; Tascanov et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">8</span></a> investigate the relationship between total oxidative status &#40;TOS&#41;&#44; DNA damage and paroxysmal AF &#40;PAF&#41;&#46; The authors compared a series of 56 patients with paroxysmal AF to healthy controls and reported higher high-sensitivity C-reactive protein&#44; TOS and 8-hydroxy-2&#8242;-deoxyguanosine &#40;8-OHdG&#41; levels in the PAF group&#46; Furthermore&#44; they propose that TOS and DNA damage can be used to detect patients at higher risk of AF&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Elevated TOS levels have been related to AF in patients admitted for ST-elevation myocardial infarction<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">9</span></a> and patients referred for coronary artery bypass graft surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">10</span></a> Also&#44; blood 8-OHdG levels &#40;indicating DNA damage&#41; levels have been related to progression from paroxysmal to persistent AF and have been proposed as a biomarker for AF staging and recurrence after cardioversion and pulmonary vein isolation&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">11</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Tascanov et al&#46;&#8217;s findings add to this body of evidence by relating TOS and DNA damage in a general population with PAF&#44; but they do not go on to clarify a potential causal relationship&#46; Whether oxidative stress &#40;OS&#41; causes AF&#44; AF increases OS&#44; or they are independent markers of atrial cardiomyopathy&#44; remains to be answered&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">12</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The authors propose using TOS and DNA damage to identify patients at higher risk for AF&#46; Current strategies to mitigate the consequences of AF focus on early diagnosis and treatment and&#44; to achieve this&#44; opportunistic and systematic screening for AF is recommended for patients at higher thromboembolic risk&#44; mostly defined by age over 65 years and other clinical variables&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">13</span></a> In the future&#44; if TOS&#44; DNA damage or other biomarkers prove to be effective in better stratifying and identifying individuals at highest risk of AF to target screening&#44; they could add value to the current approach&#46; Better identifying a population at high risk of developing AF would help not only to improve screening efforts but also to select patients who could benefit from more aggressive risk factor management&#46; Nevertheless&#44; any potential change to the current benchmark needs not only to prove cost-effectiveness but to be widely available in clinical practice&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Finally&#44; current AF treatment relies mostly on stroke prevention&#44; rate and rhythm control&#46; Further insight into the pathogenesis of AF may also unveil novel treatment options that could help delay or ideally suppress AF progression&#46; Future research should focus on the translation of our basic understanding of the role of oxidative stress in AF pathophysiology into more focused preventive strategies and more effective treatment options&#44; and for this&#44; the possible causative relation between oxidative stress and atrial fibrillation still needs to be clarified&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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Editorial comment
Oxidative stress and atrial fibrillation – association or causation?
Stress oxidativo e fibrilhação auricular – associação ou causa?
Francisco Moscoso Costaa,b,c,
Autor para correspondência
fmoscosocosta@gmail.com

Corresponding author.
, Fu Siong Ngd
a Department of Cardiology, Santa Cruz Hospital, Portugal
b Heart Rhythm Center, Hospital da Luz Lisboa, Portugal
c Department of Cardiology, Hospital da Luz Setubal, Portugal
d National Heart & Lung Institute, Imperial College London, United Kingdom
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Atrial fibrillation &#40;AF&#41; is the commonest arrhythmia&#44; with &#62;8 million people in the European Union estimated to have AF in 2010&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">1</span></a> AF increases mortality at least 1&#46;5-fold&#44; is responsible for an increase in embolic strokes&#44; and can also cause a range of debilitating symptoms&#46; At present&#44; treatments for AF&#44; especially persistent AF&#44; have limited success&#46; Catheter ablation&#44; which is a key treatment for AF&#44; has a ceiling of success of approximately 50&#37; in persistent AF&#46; A possible reason for the lack of success in treating persistent AF may be that current antiarrhythmic medications and ablation strategies do not adequately target the underlying mechanisms of AF and its pathophysiology&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The pathophysiology of AF is complex&#46; The pulmonary veins are important triggers for AF&#44; and a number of electrophysiological &#40;e&#46;g&#46; reduced IK1 and ICa-L currents&#41; and anatomical &#40;branching fibers with limited lateral coupling and abrupt fiber orientation change&#41; features predispose the pulmonary veins to ectopy&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> This has led to electrical isolation of the pulmonary veins being the cornerstone of AF ablation&#46; However&#44; the triggers are only part of the story&#44; and remodeling of the atrial substrate is equally&#44; if not more&#44; important&#46; The atrial substrate undergoes a series of adverse remodeling changes&#44; including upregulation of potassium channels leading to a reduction in action potential duration&#44; increased fibrosis and a reduction in gap junction coupling&#46; These abnormalities of conduction and refractoriness all promote re-entry&#44; and thus the maintenance of AF&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">An often neglected aspect of AF pathophysiology is the potential role played by inflammation and oxidative stress in creating the electrical and structural remodeling that predisposes to AF&#46; Inflammatory markers have been shown to be increased in patients with AF&#46; Furthermore&#44; in chronic inflammatory conditions such as rheumatoid arthritis&#44; there are approximately 1&#46;5- and 2&#46;0-fold increases in atrial arrhythmias and sudden cardiac death&#44; respectively&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">4</span></a> This is because inflammatory cytokines&#44; such as interleukin &#40;IL&#41;-1&#44; IL-6 and tumor necrosis factor alpha&#44; increase fibrosis by causing cardiac fibroblasts to proliferate&#44; promoting differentiation to myofibroblasts&#44; and increasing collagen deposition&#46; They also modulate the activity of a number of ion currents&#44; for example reducing the transient outward current &#40;Ito&#41; and both components of the delayed rectifier potassium current &#40;IKs and Ikr&#41; to reduce refractoriness&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">5</span></a> all of which combine to promote arrhythmogenesis&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Oxidative stress&#44; which is increased in inflammation&#44; is also thought to play an important role in AF&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">6</span></a> Increased reactive oxygen species &#40;ROS&#41;&#44; more specifically&#44; increased nicotinamide adenine dinucleotide phosphate oxidase &#40;NOX&#41; and endothelial nitric oxide synthase activity&#44; have been demonstrated in patients with AF&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">7</span></a> Increased NOX can promote fibrosis through stimulation of transforming growth factor beta&#44; which then increases atrial arrhythmogenesis&#46; Furthermore&#44; ROS signaling has also been shown to modulate both ion channel function and calcium-induced calcium release&#44; both directly and via second messenger systems&#46; However&#44; despite evidence linking oxidative stress with AF&#44; antioxidant therapy has not been shown to reduce AF in clinical trials&#46; This may be because existing antioxidant therapies are not sufficiently targeting the key oxidative stress pathways&#46; Another possible reason is that increased oxidative stress is merely associated with AF&#44; and is a general marker for atrial myopathy&#44; but does not play a key role in AF pathogenesis&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In this issue of the <span class="elsevierStyleItalic">Journal</span>&#44; Tascanov et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">8</span></a> investigate the relationship between total oxidative status &#40;TOS&#41;&#44; DNA damage and paroxysmal AF &#40;PAF&#41;&#46; The authors compared a series of 56 patients with paroxysmal AF to healthy controls and reported higher high-sensitivity C-reactive protein&#44; TOS and 8-hydroxy-2&#8242;-deoxyguanosine &#40;8-OHdG&#41; levels in the PAF group&#46; Furthermore&#44; they propose that TOS and DNA damage can be used to detect patients at higher risk of AF&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Elevated TOS levels have been related to AF in patients admitted for ST-elevation myocardial infarction<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">9</span></a> and patients referred for coronary artery bypass graft surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">10</span></a> Also&#44; blood 8-OHdG levels &#40;indicating DNA damage&#41; levels have been related to progression from paroxysmal to persistent AF and have been proposed as a biomarker for AF staging and recurrence after cardioversion and pulmonary vein isolation&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">11</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Tascanov et al&#46;&#8217;s findings add to this body of evidence by relating TOS and DNA damage in a general population with PAF&#44; but they do not go on to clarify a potential causal relationship&#46; Whether oxidative stress &#40;OS&#41; causes AF&#44; AF increases OS&#44; or they are independent markers of atrial cardiomyopathy&#44; remains to be answered&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">12</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The authors propose using TOS and DNA damage to identify patients at higher risk for AF&#46; Current strategies to mitigate the consequences of AF focus on early diagnosis and treatment and&#44; to achieve this&#44; opportunistic and systematic screening for AF is recommended for patients at higher thromboembolic risk&#44; mostly defined by age over 65 years and other clinical variables&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">13</span></a> In the future&#44; if TOS&#44; DNA damage or other biomarkers prove to be effective in better stratifying and identifying individuals at highest risk of AF to target screening&#44; they could add value to the current approach&#46; Better identifying a population at high risk of developing AF would help not only to improve screening efforts but also to select patients who could benefit from more aggressive risk factor management&#46; Nevertheless&#44; any potential change to the current benchmark needs not only to prove cost-effectiveness but to be widely available in clinical practice&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Finally&#44; current AF treatment relies mostly on stroke prevention&#44; rate and rhythm control&#46; Further insight into the pathogenesis of AF may also unveil novel treatment options that could help delay or ideally suppress AF progression&#46; Future research should focus on the translation of our basic understanding of the role of oxidative stress in AF pathophysiology into more focused preventive strategies and more effective treatment options&#44; and for this&#44; the possible causative relation between oxidative stress and atrial fibrillation still needs to be clarified&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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