array:26 [
  "pii" => "S0870255120300810"
  "issn" => "08702551"
  "doi" => "10.1016/j.repc.2019.11.003"
  "estado" => "S300"
  "fechaPublicacion" => "2020-02-01"
  "aid" => "1497"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2020"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Cardiol. 2020;39:89-96"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "en" => array:20 [
      "pii" => "S2174204920301380"
      "issn" => "21742049"
      "doi" => "10.1016/j.repce.2020.05.006"
      "estado" => "S300"
      "fechaPublicacion" => "2020-02-01"
      "aid" => "1503"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "dis"
      "cita" => "Rev Port Cardiol. 2020;39:97-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
        "titulo" => "Mast cells&#58; Promoters of myocardial fibrosis in hypertensive heart disease&#63;"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "97"
            "paginaFinal" => "98"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "Mast&#243;citos&#58; promotores da fibrose mioc&#225;rdica na doen&#231;a hipertensiva card&#237;aca&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Rosa Henriques de Gouveia"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "Rosa Henriques de"
                "apellidos" => "Gouveia"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0870255120300871"
          "doi" => "10.1016/j.repc.2020.03.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255120300871?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204920301380?idApp=UINPBA00004E"
      "url" => "/21742049/0000003900000002/v1_202005210836/S2174204920301380/v1_202005210836/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S0870255120300871"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2020.03.004"
    "estado" => "S300"
    "fechaPublicacion" => "2020-02-01"
    "aid" => "1503"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "dis"
    "cita" => "Rev Port Cardiol. 2020;39:97-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
      "titulo" => "Mast cells&#58; Promoters of myocardial fibrosis in hypertensive heart disease&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "97"
          "paginaFinal" => "98"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Mast&#243;citos&#58; promotores da fibrose mioc&#225;rdica na doen&#231;a hipertensiva card&#237;aca&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rosa Henriques de Gouveia"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Rosa Henriques de"
              "apellidos" => "Gouveia"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2174204920301380"
        "doi" => "10.1016/j.repce.2020.05.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204920301380?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255120300871?idApp=UINPBA00004E"
    "url" => "/08702551/0000003900000002/v1_202005070648/S0870255120300871/v1_202005070648/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S0870255120300883"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2020.03.005"
    "estado" => "S300"
    "fechaPublicacion" => "2020-02-01"
    "aid" => "1504"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "dis"
    "cita" => "Rev Port Cardiol. 2020;39:85-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
      "titulo" => "Tobacco use&#58; More needs to be done to control active and passive smoking"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "85"
          "paginaFinal" => "87"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Consumo de tabaco - para controlar o tabagismo ativo e passivo &#233; neces&#225;rio fazer mais"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Evangelista Rocha"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Evangelista"
              "apellidos" => "Rocha"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2174204920301367"
        "doi" => "10.1016/j.repce.2020.05.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204920301367?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255120300883?idApp=UINPBA00004E"
    "url" => "/08702551/0000003900000002/v1_202005070648/S0870255120300883/v1_202005070648/en/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:20 [
      "pii" => "S0870255120300871"
      "issn" => "08702551"
      "doi" => "10.1016/j.repc.2020.03.004"
      "estado" => "S300"
      "fechaPublicacion" => "2020-02-01"
      "aid" => "1503"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "dis"
      "cita" => "Rev Port Cardiol. 2020;39:97-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
        "titulo" => "Mast cells&#58; Promoters of myocardial fibrosis in hypertensive heart disease&#63;"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "97"
            "paginaFinal" => "98"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "Mast&#243;citos&#58; promotores da fibrose mioc&#225;rdica na doen&#231;a hipertensiva card&#237;aca&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Rosa Henriques de Gouveia"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "Rosa Henriques de"
                "apellidos" => "Gouveia"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2174204920301380"
          "doi" => "10.1016/j.repce.2020.05.006"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204920301380?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255120300871?idApp=UINPBA00004E"
      "url" => "/08702551/0000003900000002/v1_202005070648/S0870255120300871/v1_202005070648/en/main.assets"
    ]
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
    "titulo" => "Analysis of mast cells and myocardial fibrosis in autopsied patients with hypertensive heart disease"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "89"
        "paginaFinal" => "96"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Guilherme Ribeiro Juliano, Mariana Fleury Skaf, Luciana Santos Ramalho, Gabriela Ribeiro Juliano, Bianca Gon&#231;alves Silva Torquato, Mariana Silva Oliveira, Fl&#225;via Aparecida Oliveira, Ana Paula Esp&#237;ndula, Camila Lourencini Cavellani, Vicente de Paula Antunes Teixeira, Mara L&#250;cia da Fonseca Ferraz"
        "autores" => array:11 [
          0 => array:4 [
            "nombre" => "Guilherme Ribeiro"
            "apellidos" => "Juliano"
            "email" => array:1 [
              0 => "guiribeiro85@yahoo.com.br"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Mariana Fleury"
            "apellidos" => "Skaf"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Luciana Santos"
            "apellidos" => "Ramalho"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Gabriela Ribeiro"
            "apellidos" => "Juliano"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Bianca Gon&#231;alves Silva"
            "apellidos" => "Torquato"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Mariana Silva"
            "apellidos" => "Oliveira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Fl&#225;via Aparecida"
            "apellidos" => "Oliveira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Ana Paula"
            "apellidos" => "Esp&#237;ndula"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "Camila Lourencini"
            "apellidos" => "Cavellani"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          9 => array:3 [
            "nombre" => "Vicente de Paula Antunes"
            "apellidos" => "Teixeira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          10 => array:3 [
            "nombre" => "Mara L&#250;cia da Fonseca"
            "apellidos" => "Ferraz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "General Pathology Department&#44; Biological and Natural Sciences Institute &#40;ICBN&#41;&#44; Federal University of Tri&#226;ngulo Mineiro &#40;UFTM&#41;&#44; Uberaba&#44; MG&#44; Brazil"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Institute of Tropical Pathology and Public Health &#40;IPTSP&#41;&#44; Federal University of Goi&#225;s &#40;UFG&#41;&#44; Goi&#226;nia&#44; GO&#44; Brazil"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "An&#225;lise dos mast&#243;citos e fibrose mioc&#225;rdica em pacientes autopsiados com cardiopatia hipertensiva"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1076
            "Ancho" => 1422
            "Tamanyo" => 68725
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Correlation between collagen fibers and density of mast cells immunolabeled with anti-tryptase antibodies&#46; Linear regression fit<span class="elsevierStyleMonospace">&#61;</span>2&#46;96<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>0&#46;21&#46; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;02&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0010" class="elsevierStylePara elsevierViewall">Cardiovascular disease is the leading cause of mortality worldwide&#44; and in Brazil is responsible for about 20&#37; of all deaths in people over 30 years of age&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">1</span></a> There has been a change in recent years of the main causes of morbidity and mortality from infectious diseases to cardiovascular disease&#44; cancer&#44; and other chronic diseases&#44; such as systemic hypertension &#40;the epidemiological transition&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">2&#8211;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">One of the consequences of untreated systemic hypertension&#44; which induces cardiac lesions and left ventricular &#40;LV&#41; hypertrophy&#44; is hypertensive heart disease&#46; A new component of the pathophysiology of hypertensive heart disease has been described&#58; apoptosis of cardiomyocytes and changes in collagen synthesis and degradation&#44; which may play an important role in the development of LV hypertrophy and myocardial injury&#46;<a class="elsevierStyleCrossRefs" href="#bib0395"><span class="elsevierStyleSup">6&#8211;8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Studies have shown that chronic LV overload increases the density of cardiac mast cells&#44; which when activated release a range of potent inflammatory and pro-fibrotic mediators that play an active part in cardiac remodeling&#46;<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The mechanisms underlying progression of collagen deposition and fibrosis as a result of the presence of cardiac mast cells have not been fully elucidated&#46; Therefore&#44; the purpose of this study was to assess the formation of collagen fibers and mast cell density in hypertensive heart disease&#44; in order to improve our understanding of the pathological processes involved&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Hypothesis</span><p id="par0040" class="elsevierStylePara elsevierViewall">We hypothesize that mast cells are involved in the development of hypertensive heart disease&#44; contributing to the remodeling of collagen fibers in this disease&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Background</span><p id="par0045" class="elsevierStylePara elsevierViewall">Experimental studies have reported that cardiac mast cells are involved in myocardial fibrosis&#46; The first to describe this association were Olivetti et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">11</span></a> who observed an increase in cardiac mast cells in the right ventricle of rats with pulmonary artery stenosis&#44; although they did not indicate whether the mast cells were associated with fibrosis&#46; Panizo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">12</span></a> first investigated mast cells in the left ventricle in systemic hypertension&#44; and noted a strong correlation between increased mast cell density and increased collagen&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Activated cardiac mast cells release a number of potent inflammatory and pro-fibrotic mediators&#44; including cytokines&#44; chemokines&#44; and proteases&#46; They can be activated by immunoglobulin E&#44; by factors and histamine released by neighboring macrophages or T lymphocytes&#44; or by components of the complement system &#40;C3a and C5a&#41;&#46; Once activated&#44; they initiate degranulation&#44; which is the process of exocytosis of the components of their granules&#46;<a class="elsevierStyleCrossRefs" href="#bib0430"><span class="elsevierStyleSup">13&#44;14</span></a> Other factors that activate cardiac mast cells have not been clearly identified&#44; but endothelin-1&#44; reactive oxygen species&#44; substance P and interleukin &#40;IL&#41;-33 appear to be involved in the process&#46;<a class="elsevierStyleCrossRefs" href="#bib0415"><span class="elsevierStyleSup">10&#44;15&#8211;17</span></a> The most abundant proteins stored in the secretory granules of mast cells are endopeptidases&#44; of which the most important are tryptase and chymase&#46; Both are serine proteases&#44; but they differ in activity and in expression patterns&#46;<a class="elsevierStyleCrossRefs" href="#bib0455"><span class="elsevierStyleSup">18&#44;19</span></a> Mast cells maturing in microenvironments of different tissues may vary in the type and amount of tryptase and chymase expressed&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The physiological role of tryptase and chymase is still unclear and their activity is observed not in normal tissues&#44; but in tissues with lesions&#46; Tryptase is the predominant enzyme in the granules&#46;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">20</span></a> Human mast cells that contain tryptase in their granules express protease-activated receptor 2 &#40;PAR-2&#41;&#46; In vitro studies have shown that pretreatment of these cells with the PAR-2 activating peptide upregulates IL-8 &#40;CXCL8&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">21</span></a> Incubation of tryptase in endothelial cell cultures induces neutrophil migration&#44; which is dependent on IL-8&#46;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">22</span></a> Another study demonstrated that incubation of cardiac fibroblasts with tryptase resulted in collagen proliferation and synthesis&#46;<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">23</span></a> It has been shown that chymase is able to convert angiotensin I into angiotensin II<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">24</span></a> and is probably involved in structural remodeling associated with diseases of the cardiovascular system&#46;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">18</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">It is clear that mast cells play an important role in various cardiac diseases&#44; but due to the complex composition of the secretory granules and the plasticity of their phenotype&#44; their contribution remains to be clarified&#46;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">25</span></a> Molecular studies have been proposed in order to characterize the key genes involved in the modulation of these pathological processes&#44; but they are still in their early stages and their findings cannot as yet be used in clinical practice&#46;<a class="elsevierStyleCrossRefs" href="#bib0495"><span class="elsevierStyleSup">26&#8211;30</span></a> Since mast cells express some peptidases at high levels&#44; immunohistochemistry and immunoassays using antibodies directed against these enzymes are experimentally useful to assess numbers of mast cells&#44; their activation sites and associated diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">31</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Methods</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Sample collection</span><p id="par0065" class="elsevierStylePara elsevierViewall">Fragments were collected from the middle third of the LV free wall from 30 individuals autopsied by two pathologists at the Clinical Hospital of the Federal University of Tri&#226;ngulo Mineiro &#40;UFTM&#41;&#44; between 1987 and 2017&#46; The autopsy protocols were analyzed to obtain data including age&#44; gender&#44; race&#44; heart weight and body weight&#46; Samples from individuals aged 18 or older were selected and then divided into two groups&#58; those with hypertensive heart disease &#40;HD&#41; &#40;n<span class="elsevierStyleMonospace">&#61;</span>15&#41; and those with no heart disease &#40;ND&#41; &#40;n<span class="elsevierStyleMonospace">&#61;</span>15&#41;&#46; Cases with an incomplete autopsy report and individuals with Chagas disease or any other heart disease were excluded from the study&#46; The ratio of heart weight &#40;g&#41; to body weight &#40;g&#41;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>100&#44; used in the definition of cardiac hypertrophy&#44; was calculated in all cases&#46;<a class="elsevierStyleCrossRef" href="#bib0525"><span class="elsevierStyleSup">32</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Sample preparation</span><p id="par0070" class="elsevierStylePara elsevierViewall">The LV fragments had been fixed in 10&#37; formaldehyde&#46; They were first dehydrated in alcohols of increasing concentration &#40;70-100&#37;&#41;&#44; cleared in xylene and embedded in paraffin&#46;<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">33</span></a> They were then cut into 4-&#956;m sections and slide 1 was stained with picrosirius red&#44; counter-colored with hematoxylin&#44; for quantification of collagen fibers&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Morphometric analysis of collagen fibers</span><p id="par0075" class="elsevierStylePara elsevierViewall">The number of fields for assessment and quantification of collagen fibers in the left ventricle was defined by the test of cumulative means&#46;<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">34</span></a> The histological section was divided into four quadrants and 40 fields of each fragment were digitized&#46; Under polarized light the area of collagen fibers had a birefringent appearance&#44; ranging from greenish yellow to reddish orange &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figures 1</a>A and B&#41;&#46; The collagen fibers were marked by the observer to obtain the percentage of collagen per field&#46; The quantified image field was then scanned by a camera attached to the microscope&#46; The morphometric analysis was performed using a LeicaQWin&#174; Plus image analyzer &#40;Leica Microsystems&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Immunohistochemical analysis</span><p id="par0080" class="elsevierStylePara elsevierViewall">Slides 2 and 3 were used for immunohistochemical analysis to determine positivity to anti-human mast cell chymase antibodies &#40;Diagnostic BioSystems&#174;&#41; diluted to 1&#58;2000 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figures 1</a>C and D&#41; and anti-human mast cell tryptase antibodies &#40;Diagnostic BioSystems&#174;&#41; diluted to 1&#58;500 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figures 1</a>E and F&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">35</span></a> Immunostained mast cells were quantified using a video camera connected to a conventional light microscope and to a computer with AxioVision&#174; Rel 4&#46;9&#46;1 image analysis software &#40;Carl Zeiss&#41;&#46; Mast cells were quantified along the length of the section using a final magnification of 500<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>in a microscope field of 0&#46;1520 mm<span class="elsevierStyleSup">2</span>&#46; The fragments were divided into four quadrants and&#44; in each quadrant&#44; ten randomly selected fields were quantified&#46; The density of mast cells in each fragment was determined by dividing the total number of mast cells in the 40 quantified fields by the total area of the field&#44; expressed in mast cells&#47;mm<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">2</span></a>&#46;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">18</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Statistical analysis</span><p id="par0085" class="elsevierStylePara elsevierViewall">The data were analyzed using GraphPad Prism&#174; 5 software &#40;GraphPad Software&#41;&#46; The Shapiro-Wilk test was applied to test for normality of distribution of variables&#46; The Student&#39;s t test &#40;t&#41; was used to compare groups for normally distributed variables and the Mann-Whitney U test for non-normal distributions&#46; The correlation between two variables with normal distribution was analyzed using Pearson&#39;s test &#40;r&#41;&#44; and for those presenting non-normal variance&#44; Spearman&#39;s test was used&#46; Differences were considered statistically significant for p&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Ethical considerations</span><p id="par0090" class="elsevierStylePara elsevierViewall">This study was approved by the Research Ethics Committee of the Federal University of Tri&#226;ngulo Mineiro through protocol no&#46; 1373&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Results</span><p id="par0095" class="elsevierStylePara elsevierViewall">Regarding the general characteristics of the sample&#44; the mean age of individuals in the HD group was 49&#46;8&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;2 years&#44; ranging from 44 to 66 years&#44; and in the ND group the mean age was 55&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;9 years&#44; ranging from 45 to 80 years&#46; With regard to gender&#44; 17 individuals &#40;56&#46;6&#37;&#41; were male and 13 &#40;43&#46;3&#37;&#41; were female&#46; Considering race&#44; 19 individuals &#40;63&#46;3&#37;&#41; were white and 11 &#40;36&#46;6&#37;&#41; were non-white&#46; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">When the HD and ND groups were compared&#44; a significantly higher percentage of collagen fibers in the left ventricle was seen in the HD group compared to the ND group &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;003&#41;&#46; Mast cell density was also significantly higher in LV samples from individuals with HD immunolabeled with anti-chymase and anti-tryptase antibodies &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;02&#41; and also in samples immunolabeled only with anti-tryptase antibodies &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;03&#41;&#46; Heart weight was also significantly greater in HD compared to ND &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Analyzing the HD group&#44; there was a significant positive correlation between the percentage of collagen fibers in the left ventricle and the density of mast cells immunolabeled with anti-chymase and anti-tryptase antibodies &#40;r<span class="elsevierStyleMonospace">&#61;</span>0&#46;517&#44; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;04&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41; and also those immunolabeled only with anti-tryptase antibodies &#40;r<span class="elsevierStyleMonospace">&#61;</span>0&#46;574&#44; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;02&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>&#41;&#46; There was no significant correlation between the percentage of collagen fibers in the left ventricle and mast cell density in the ND group &#40;data not shown&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">There was no significant difference between percentage of collagen fibers&#44; mast cell density and heart weight in terms of gender&#44; race or age in either group&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discussion</span><p id="par0115" class="elsevierStylePara elsevierViewall">Systemic hypertension leads to structural and functional changes in the heart&#46;<a class="elsevierStyleCrossRef" href="#bib0545"><span class="elsevierStyleSup">36</span></a> In our study&#44; we found an increase in collagen fibers in the HD group compared to the ND group&#46; This finding is in line with the literature&#44; which reports that fibrosis is among the morphological changes most often found in patients with hypertensive heart disease&#46; It is characterized by diffuse or excessive accumulation of collagen fibers and increasing myocardial stiffness&#44; which can lead to LV dysfunction and&#44; eventually&#44; heart failure&#46;<a class="elsevierStyleCrossRefs" href="#bib0550"><span class="elsevierStyleSup">37&#8211;39</span></a> This reactive fibrosis is characteristic of pathological processes that trigger myocardial hypertrophy&#46;<a class="elsevierStyleCrossRefs" href="#bib0395"><span class="elsevierStyleSup">6&#44;40</span></a> The mechanisms responsible for the progression of LV hypertrophy include not only response to mechanical stress&#44; but also the influence of neurohormones&#44; growth factors and cytokines&#46;<a class="elsevierStyleCrossRefs" href="#bib0570"><span class="elsevierStyleSup">41&#44;42</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Another study on the quantification of collagen in autopsied hearts of hypertensive and non-hypertensive individuals showed increased collagen in hypertensive patients with LV hypertrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">43</span></a> This finding is in agreement with our research&#46; Other studies have shown that type I collagen metabolism is increased in both humans and mice with hypertensive heart disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0585"><span class="elsevierStyleSup">44&#44;45</span></a> Research has shown a close relationship between non-invasive histological diagnosis of myocardial fibrosis in animals and hypertensive patients and biochemical markers such as the carboxy-terminal propeptide of procollagen type I&#46;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">37</span></a> Serum levels of this propeptide were higher in patients with hypertensive heart disease than in those with no heart disease&#44;<a class="elsevierStyleCrossRef" href="#bib0595"><span class="elsevierStyleSup">46</span></a> showing that the precursors of collagen synthesis are increased in individuals affected by hypertensive heart disease&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">It has also been demonstrated that the ratio of serum matrix metalloproteinase &#40;MMP&#41;-1 and its tissue inhibitors is altered in patients with hypertensive heart disease&#44;<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">47</span></a> and that patients with reduced ejection fraction due to LV chamber dilatation present changes in the distribution of collagen fibers&#44; mainly perivascular and scar&#44; and considerable increases in MMP-1&#46;<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">40</span></a> These findings are related to the results of the present study&#44; as activated MMPs are the main mediators of myocardial remodeling&#44; mainly through the release of tryptase&#44; which cleaves the pro-MMP-3 precursor&#44; activating MMP-3 which then activates MMP-1&#44; and through the release of chymase&#44; which activates MMP-2 and MMP-9&#46;<a class="elsevierStyleCrossRefs" href="#bib0605"><span class="elsevierStyleSup">48&#8211;53</span></a> This remodeling appears to be critical to the progression of LV hypertrophy&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">In the present study&#44; we found a significant increase in the density of mast cells in the left ventricle of individuals with hypertensive heart disease&#46; Experimental studies that help explain our results demonstrated increased mast cell density in LV overload conditions and myocardial remodeling&#46;<a class="elsevierStyleCrossRefs" href="#bib0445"><span class="elsevierStyleSup">16&#44;23&#44;50</span></a> The products of mast cell degranulation&#44; besides activating the innate immune system&#44; are pro-inflammatory&#44; pro-fibrogenic and pro-hypertrophic&#46; Among them are transforming growth factor beta &#40;TGF-&#946;&#41;&#44; histamine&#44; chymase&#44; tryptase&#44; IL-4 and tumor necrosis factor alpha&#44;<a class="elsevierStyleCrossRefs" href="#bib0575"><span class="elsevierStyleSup">42&#44;54&#8211;58</span></a> which correlates with the significant increase in collagen fibers in the left ventricle of patients with hypertensive heart disease&#46; It is established in the literature that protein kinase C &#40;PKC&#41; is a convergence point for these events&#46;<a class="elsevierStyleCrossRef" href="#bib0660"><span class="elsevierStyleSup">59</span></a> Although in vitro studies have implicated PKC in mast cell degranulation&#44; this has not been demonstrated in in vivo studies using heart failure models&#46;<a class="elsevierStyleCrossRef" href="#bib0665"><span class="elsevierStyleSup">60</span></a> In a study on hypertensive rats&#44; it was demonstrated that inhibition of the PKC pathway attenuated mast cell degranulation without affecting mast cell density&#46; This treatment also inhibited the infiltration of inflammatory cells&#44; vasculopathy and fibrosis in the myocardium&#46;<a class="elsevierStyleCrossRef" href="#bib0670"><span class="elsevierStyleSup">61</span></a> Another study in rats with hyperlipidemia using Western blot analysis and immunohistochemical staining demonstrated that protein expression of TGF-&#946; in the hearts of hyperlipidemic rats was significantly higher than in the control group&#46;<a class="elsevierStyleCrossRef" href="#bib0675"><span class="elsevierStyleSup">62</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">The lower percentage of collagen fibers and mast cell density in the left ventricle of women with hypertensive heart disease was not significant&#59; however&#44; this was also an expected result&#46; The prevalence of prehypertension and hypertension in the literature is lower in women than in men&#46;<a class="elsevierStyleCrossRef" href="#bib0680"><span class="elsevierStyleSup">63</span></a> It appears that women suffer less effects from hypertension than men&#44; due &#8211; among other factors &#8211; to the protective effects of endogenous estrogen&#46;<a class="elsevierStyleCrossRef" href="#bib0685"><span class="elsevierStyleSup">64</span></a> Bearing in mind the mean age of 54 years of the women analyzed&#44; according to a study that reports that cardiac hypertrophy is more prevalent in menopausal women as a result of reduced levels of cardioprotective female sex hormones&#44;<a class="elsevierStyleCrossRef" href="#bib0690"><span class="elsevierStyleSup">65</span></a> these hormones also suppress the action of MMPs by reducing levels of cytokines such as TNF-&#945;<a class="elsevierStyleCrossRef" href="#bib0695"><span class="elsevierStyleSup">66</span></a> that control the activation of mast cells&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">With regards to race&#44; although non-white subjects had higher percentages of collagen fibers&#44; the relationship between hypertensive heart disease and skin color is controversial&#46; The ethnically mixed nature of the Brazilian population makes race a criterion of lesser validity for assessing the risk of developing heart disease&#46;<a class="elsevierStyleCrossRef" href="#bib0700"><span class="elsevierStyleSup">67</span></a> An autopsy study found that LV hypertrophy was not more prevalent in black patients&#44;<a class="elsevierStyleCrossRef" href="#bib0705"><span class="elsevierStyleSup">68</span></a> but in this study hypertension was an exclusion criterion&#44; unlike our study&#44; in which some subjects were hypertensive&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Studies have shown a relationship between severity and duration of hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0710"><span class="elsevierStyleSup">69</span></a> It has also been suggested that genetic control of ventricular mass may differ in different ethnic groups&#46;<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">27</span></a> Other studies have presented evidence to suggest that LV hypertrophy contributes to a higher frequency of sudden death&#44; especially among black patients&#46;<a class="elsevierStyleCrossRef" href="#bib0715"><span class="elsevierStyleSup">70</span></a> Systemic hypertension is one of the main causes of disparities in mortality rates between blacks and whites in the USA&#44; due to differences in prevalence and control&#46; Other data suggest that primary care and social and environmental conditions reinforce this disparity in the prevalence of severe hypertension among blacks and whites&#46;<a class="elsevierStyleCrossRefs" href="#bib0700"><span class="elsevierStyleSup">67&#44;71&#44;72</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">In our study&#44; there was a non-significant increase in the percentage of collagen fibers with age&#46; This finding may be due to the severity of systemic hypertension&#44; since the mean age of the individuals analyzed in the study was 49&#46;8 years in patients with hypertensive heart disease&#46;<a class="elsevierStyleCrossRef" href="#bib0730"><span class="elsevierStyleSup">73</span></a></p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conclusions</span><p id="par0155" class="elsevierStylePara elsevierViewall">Our study showed that&#44; in patients with hypertensive heart disease&#44; there is an increase in collagen fibers in the left ventricle&#46; This reactive fibrosis is a fundamental component of the process of myocardial hypertrophy&#46; The increase in the density of mast cells in the left ventricle of patients with hypertensive heart disease observed in the study indicates that mast cells have an important role in myocardial remodeling in hypertensive heart disease&#46; Additional studies will help elucidate the mechanisms of collagen turnover&#44; so that therapeutic targets may be determined in order to regulate the actions of the main proteases released in the activation of mast cells&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Funding</span><p id="par0160" class="elsevierStylePara elsevierViewall">The present study was supported by the National Council for Scientific and Technological Development &#40;<span class="elsevierStyleItalic">Conselho Nacional de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico</span>&#44; CNPq&#41;&#44; Coordination of Improvement of Higher Education Personnel &#40;<span class="elsevierStyleItalic">Coordena&#231;&#227;o de Aperfei&#231;oamento de Pessoal de N&#237;vel Superior</span>&#44; CAPES&#41;&#44; the Foundation for Research Support of the State of Minas Gerais &#40;<span class="elsevierStyleItalic">Funda&#231;&#227;o de Amparo &#224; Pesquisa do Estado de Minas Gerais</span>&#44; FAPEMIG&#41; and the Foundation Of Teaching and Research of Uberaba &#40;<span class="elsevierStyleItalic">Funda&#231;&#227;o de Ensino e Pesquisa de Uberaba</span>&#44; FUNEPU&#41;&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conflicts of interest</span><p id="par0165" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interests to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:14 [
        0 => array:3 [
          "identificador" => "xres1333277"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Objective"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1228378"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres1333276"
          "titulo" => "Resumo"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Objetivo"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclus&#245;es"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1228379"
          "titulo" => "Palavras-chave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Hypothesis"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Background"
        ]
        7 => array:3 [
          "identificador" => "sec0020"
          "titulo" => "Methods"
          "secciones" => array:6 [
            0 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Sample collection"
            ]
            1 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Sample preparation"
            ]
            2 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Morphometric analysis of collagen fibers"
            ]
            3 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Immunohistochemical analysis"
            ]
            4 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Statistical analysis"
            ]
            5 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Ethical considerations"
            ]
          ]
        ]
        8 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Results"
        ]
        9 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Discussion"
        ]
        10 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conclusions"
        ]
        11 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Funding"
        ]
        12 => array:2 [
          "identificador" => "sec0075"
          "titulo" => "Conflicts of interest"
        ]
        13 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2017-11-13"
    "fechaAceptado" => "2019-11-02"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1228378"
          "palabras" => array:3 [
            0 => "Autopsy"
            1 => "Hypertensive heart disease"
            2 => "Mast cells"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec1228379"
          "palabras" => array:3 [
            0 => "Autopsia"
            1 => "Cardiopatia hipertensiva"
            2 => "Mast&#243;citos"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To analyze the percentage of collagen fibers and mast cell density in the left ventricular myocardium of autopsied patients with and without hypertensive heart disease&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Thirty fragments of left ventricular myocardium were obtained from individuals autopsied at the Clinical Hospital of the Federal University of Tri&#226;ngulo Mineiro &#40;UFTM&#41; in the period from 1987 to 2017&#46; Individuals were divided into two groups&#58; those with hypertensive heart disease &#40;HD&#41; and those with no heart disease &#40;ND&#41;&#46; Subjects were also assessed according to age&#44; gender and race &#40;white and non-white&#41;&#46; Collagen fibers were quantified by computed morphometry and mast cell density was assessed by immunohistochemical methods&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">There were significantly more collagen fibers in the left ventricle in the HD group than in the ND group &#40;p&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Mast cell density was significantly higher in the left ventricle of individuals with HD immunolabeled with anti-chymase and anti-tryptase antibodies &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;02&#41; and also of those immunolabeled only with anti-tryptase antibodies &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;03&#41;&#46; Analyzing the HD group&#44; there was a significant positive correlation between the percentage of collagen fibers in the left ventricle and mast cell density immunolabeled by anti-chymase and anti-tryptase antibodies &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;04&#41; and also mast cell density immunolabeled only with anti-tryptase antibodies &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;02&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Mast cells are involved in the development of hypertensive heart disease&#44; contributing to the remodeling of collagen fibers in this disease&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objective"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "pt" => array:3 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Analisar a porcentagem de fibras col&#225;genas e a densidade mastocit&#225;ria no mioc&#225;rdio ventricular esquerdo de pacientes autopsiados com e sem cardiopatia hipertensiva&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Foram obtidos 30 fragmentos do mioc&#225;rdio ventricular esquerdo de indiv&#237;duos autopsiados no Hospital Cl&#237;nico da Universidade Federal do Tri&#226;ngulo Mineiro &#40;UFTM&#41; em 1987-2017&#44; agrupados em indiv&#237;duos com cardiopatia hipertensiva &#40;HD&#41; e sem cardiopatia &#40;ND&#41; e avaliados de acordo com fatores como idade&#44; sexo &#40;masculino e feminino&#41; e cor &#40;branco e n&#227;o branco&#41;&#46; A quantifica&#231;&#227;o das fibras col&#225;genas foi feita por morfometria computadorizada e a densidade mastocit&#225;ria foi avaliada por m&#233;todos imuno-histoqu&#237;micos&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Houve aumento significativo das fibras col&#225;genas no ventr&#237;culo esquerdo no grupo HD em compara&#231;&#227;o com o grupo ND &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Quanto &#224; densidade mastocit&#225;ria&#44; houve aumento significativo no ventr&#237;culo esquerdo de indiv&#237;duos com HD imunomarcados por antiquimase&#47;antitriptase &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#44;02&#41; e tamb&#233;m na densidade mastocit&#225;ria no ventr&#237;culo esquerdo de indiv&#237;duos imunomarcados por antitriptase &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#44;03&#41;&#46; Analisando o grupo de HD&#44; houve uma correla&#231;&#227;o positiva e significativa entre a porcentagem de fibras col&#225;genas no ventr&#237;culo esquerdo e a densidade mastocit&#225;ria no ventr&#237;culo esquerdo imunomarcados por antiquimase&#47;antitriptase &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#44;04&#41; e tamb&#233;m na densidade mastocit&#225;ria no ventr&#237;culo esquerdo de indiv&#237;duos imunomarcados por antitriptase &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#44;02&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#245;es</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Os mast&#243;citos est&#227;o envolvidos no desenvolvimento da cardiopatia hipertensiva&#44; contribuem para a remodela&#231;&#227;o das fibras col&#225;genas nessa doen&#231;a&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclus&#245;es"
          ]
        ]
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2427
            "Ancho" => 2167
            "Tamanyo" => 478487
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Histological section of a fragment of left ventricle examined &#40;A&#41; under visible light &#40;arrows&#41; &#40;picrosirius stain&#44; 200<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>&#41; and &#40;B&#41; under polarized light&#44; which reveals birefringent collagen fibers &#40;arrows&#41; &#40;picrosirius stain&#44; 200<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>&#41;&#59; &#40;C and D&#41; mast cells &#40;arrows&#41; immunolabeled with anti-chymase antibodies &#40;immunohistochemistry&#44; 200<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>and 400<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>&#41;&#59; &#40;E and F&#41; mast cells &#40;arrows&#41; immunolabeled with anti-tryptase antibodies &#40;immunohistochemistry&#44; 200<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>and 400<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1071
            "Ancho" => 1411
            "Tamanyo" => 67469
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Correlation between collagen fibers and density of mast cells immunolabeled with anti-chymase and anti-tryptase antibodies&#46; Linear regression fit<span class="elsevierStyleMonospace">&#61;</span>3&#46;03<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>0&#46;26&#46; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;04&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1076
            "Ancho" => 1422
            "Tamanyo" => 68725
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Correlation between collagen fibers and density of mast cells immunolabeled with anti-tryptase antibodies&#46; Linear regression fit<span class="elsevierStyleMonospace">&#61;</span>2&#46;96<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>0&#46;21&#46; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;02&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">HD group &#40;n<span class="elsevierStyleMonospace">&#61;</span>15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">ND group &#40;n<span class="elsevierStyleMonospace">&#61;</span>15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age&#44; years&#44; mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Gender&#44; &#37; &#40;n&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;3 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#46;6 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Race&#44; &#37; &#40;n&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>White&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;3 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#46;3 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Non-white&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#46;6 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;6 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2285360.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">p<span class="elsevierStyleMonospace">&#61;</span>0&#46;262&#44; Student&#39;s t test&#46;</p> <p class="elsevierStyleNotepara" id="npar0010">HD&#58; hypertensive heart disease&#59; ND&#58; no heart disease&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Demographic characteristics of the sample of autopsied patients with hypertensive heart disease and without heart disease&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">&#42; p&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#44; Student&#39;s t test &#40;t&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Collagen fibers &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mast cell density &#40;mast cells&#47;mm<span class="elsevierStyleSup">2</span>&#41;</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Heart weight &#40;g&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Anti-chymase and anti-tryptase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Anti-tryptase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HD &#40;n<span class="elsevierStyleMonospace">&#61;</span>15&#41; &#40;mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;354<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;316<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;145<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;494<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;180<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;453<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">368&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#46;41<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ND &#40;n<span class="elsevierStyleMonospace">&#61;</span>15&#41; &#40;mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;059<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;252<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;754<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;291<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;986<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;259<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">303&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;83<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2285359.png"
              ]
            ]
          ]
          "notaPie" => array:4 [
            0 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">t<span class="elsevierStyleMonospace">&#61;</span>3&#46;199&#44; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;003&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">&#58; t<span class="elsevierStyleMonospace">&#61;</span>2&#46;422&#44; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;02&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0025">&#58;t<span class="elsevierStyleMonospace">&#61;</span>2&#46;287&#44; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;03&#46;</p>"
            ]
            3 => array:3 [
              "identificador" => "tblfn0025"
              "etiqueta" => "d"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0030">&#58; t<span class="elsevierStyleMonospace">&#61;</span>0&#46;016&#44; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;05&#46;</p> <p class="elsevierStyleNotepara" id="npar0035">HD&#58; hypertensive heart disease&#59; ND&#58; no heart disease&#59; t&#58; Student&#39;s t test&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Comparison of percentage of collagen fibers&#44; mast cell density and heart weight in individuals with hypertensive heart disease and without heart disease&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:73 [
            0 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mortality due to cardiovascular diseases in Brazil and in the metropolitan region of S&#227;o Paulo&#58; a 2011 update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;P&#46; Mansur"
                            1 => "D&#46; Favarato"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/s0066-782x2012005000061"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arq Bras Cardiol"
                        "fecha" => "2012"
                        "volumen" => "99"
                        "paginaInicial" => "755"
                        "paginaFinal" => "761"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22735870"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The epidemiologic transition&#58; a theory of epidemiology of population change"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;R&#46; Omram"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Milbank Mem Fund Q"
                        "fecha" => "1971"
                        "volumen" => "49"
                        "paginaInicial" => "509"
                        "paginaFinal" => "538"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5155251"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A sa&#250;de dos idosos brasileiros &#224;s v&#233;speras do s&#233;culo 21&#58; problemas&#44; proje&#231;&#245;es e alternativas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Chaimowicz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/s0034-89101997000200014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Saude Publica"
                        "fecha" => "1997"
                        "volumen" => "31"
                        "paginaInicial" => "184"
                        "paginaFinal" => "200"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9497568"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transi&#231;&#227;o epidemiol&#243;gica e o estudo de carga de doen&#231;a no Brasil"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;M&#46;A&#46; Schramm"
                            1 => "A&#46;F&#46; Oliveira"
                            2 => "I&#46;C&#46; Leite"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cien Saude Colet"
                        "fecha" => "2004"
                        "volumen" => "9"
                        "paginaInicial" => "897"
                        "paginaFinal" => "908"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The development and experience of epidemiological transition theory over four decades&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Santosa"
                            1 => "S&#46; Wall"
                            2 => "E&#46; Fottrell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3402/gha.v7.23574"
                      "Revista" => array:5 [
                        "tituloSerie" => "Glob Health Action"
                        "fecha" => "2014"
                        "volumen" => "7"
                        "paginaInicial" => "23574"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24848657"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ECM remodeling in hypertensive heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;C&#46; Berk"
                            1 => "K&#46; Fujiwara"
                            2 => "S&#46; Lehoux"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "2007"
                        "volumen" => "117"
                        "paginaInicial" => "568"
                        "paginaFinal" => "575"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cellular and molecular mechanisms of fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "T&#46;A&#46; Wynn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/path.2277"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Pathol"
                        "fecha" => "2008"
                        "volumen" => "214"
                        "paginaInicial" => "199"
                        "paginaFinal" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18161745"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S073510971600944X"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathogenesis of cardiac fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Kong"
                            1 => "P&#46; Christia"
                            2 => "N&#46;G&#46; Frangogiannis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00018-013-1349-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell Mol Life Sci"
                        "fecha" => "2014"
                        "volumen" => "71"
                        "paginaInicial" => "549"
                        "paginaFinal" => "574"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23649149"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A role for cardiac mast cells in the pathogenesis of hypertensive heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "N&#46; Shiota"
                            1 => "J&#46; Rysa"
                            2 => "P&#46;T&#46; Kovanen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00004872-200310000-00022"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2003"
                        "volumen" => "21"
                        "paginaInicial" => "1935"
                        "paginaFinal" => "1944"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14508201"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac mast cells&#58; the centrepiece in adverse myocardial remodelling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;P&#46; Levick"
                            1 => "G&#46;C&#46; Melendez"
                            2 => "E&#46; Plante"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/cvr/cvq272"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Res"
                        "fecha" => "2011"
                        "volumen" => "89"
                        "paginaInicial" => "12"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20736239"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term pressure-induced cardiac hypertrophy&#58; capillary and mast cell proliferation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Olivetti"
                            1 => "C&#46; Lagrasta"
                            2 => "R&#46; Ricci"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/ajpheart.1989.257.6.H1766"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol"
                        "fecha" => "1989"
                        "volumen" => "257"
                        "paginaInicial" => "H1766"
                        "paginaFinal" => "H1772"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2532477"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Are mast cells involved in hypertensive heart disease&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Panizo"
                            1 => "F&#46;J&#46; Mindan"
                            2 => "M&#46;F&#46; Galindo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00004872-199510000-00015"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "1995"
                        "volumen" => "13"
                        "paginaInicial" => "1201"
                        "paginaFinal" => "1208"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8586812"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "V&#46; Patella"
                            1 => "I&#46; Marino"
                            2 => "E&#46; Arbustini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.cir.97.10.971"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1998"
                        "volumen" => "97"
                        "paginaInicial" => "971"
                        "paginaFinal" => "978"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9529265"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;J&#46; Leskinen"
                            1 => "K&#46;A&#46; Lindstedt"
                            2 => "Y&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arterioscler Thromb Vasc Biol&#46;"
                        "fecha" => "2003"
                        "volumen" => "23"
                        "paginaInicial" => "238"
                        "paginaFinal" => "243"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Canines as sentinel species for assessing chronic exposures to air pollutants&#58; Part 2"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46; Calder&#243;n-Garciduenas"
                            1 => "A&#46; Mora-Tiscareno"
                            2 => "L&#46;A&#46; Fordham"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/toxsci/61.2.356"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiac pathology&#46; Toxicol Sci"
                        "fecha" => "2001"
                        "volumen" => "61"
                        "paginaInicial" => "356"
                        "paginaFinal" => "367"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11353144"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0445"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endothelin-1 mediates cardiac mast cell degranulation&#44; matrix metalloproteinase activation&#44; and myocardial remodeling in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46;B&#46; Murray"
                            1 => "J&#46;D&#46; Gardner"
                            2 => "G&#46;L&#46; Brower"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/ajpheart.00048.2004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol Heart Circ Physiol&#46;"
                        "fecha" => "2004"
                        "volumen" => "287"
                        "paginaInicial" => "H2295"
                        "paginaFinal" => "H2299"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15231495"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0450"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A novel technique for isolating functional mast cells from the heart"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46;G&#46; Morgan"
                            1 => "S&#46;P&#46; Levick"
                            2 => "T&#46;G&#46; Voloshenyuk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00011-007-6213-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Inflamm Res"
                        "fecha" => "2008"
                        "volumen" => "57"
                        "paginaInicial" => "1"
                        "paginaFinal" => "6"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18209958"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0455"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of mast cell chymase and tryptase in the progression of atherosclerosis&#58; study in 44 autopsied cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46;S&#46; Ramalho"
                            1 => "L&#46;F&#46; Oliveira"
                            2 => "C&#46;L&#46; Cavellani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.anndiagpath.2012.04.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Diagn Pathol"
                        "fecha" => "2013"
                        "volumen" => "17"
                        "paginaInicial" => "28"
                        "paginaFinal" => "31"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22658852"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0460"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adrenomedullin in mast cells of abdominal aortic aneurysm"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46; Tsuruda"
                            1 => "J&#46; Kato"
                            2 => "K&#46; Hatakeyama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cardiores.2006.02.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Res"
                        "fecha" => "2006"
                        "volumen" => "70"
                        "paginaInicial" => "158"
                        "paginaFinal" => "164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16524566"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0465"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mast cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;D&#46; Metcalfe"
                            1 => "D&#46; Baram"
                            2 => "Y&#46;A&#46; Mekori"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/physrev.1997.77.4.1033"
                      "Revista" => array:6 [
                        "tituloSerie" => "Physiol Rev"
                        "fecha" => "1997"
                        "volumen" => "77"
                        "paginaInicial" => "1033"
                        "paginaFinal" => "1079"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9354811"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0470"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased mast cell expression of PAR-2 in skin inflammatory diseases and release of IL-8 upon PAR-2 activation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;F&#46; Carvalho"
                            1 => "G&#46; Nilsson"
                            2 => "I&#46;T&#46; Harvima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0625.2009.00998.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Dermatol"
                        "fecha" => "2010"
                        "volumen" => "19"
                        "paginaInicial" => "117"
                        "paginaFinal" => "122"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19889021"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0475"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human mast cell tryptase stimulates the release of an IL-8-dependent neutrophil chemotactic activity from human umbilical vein endothelial cells &#40;HUVEC&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;J&#46; Compton"
                            1 => "J&#46;A&#46; Cairns"
                            2 => "S&#46;T&#46; Holgate"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Exp Immunol"
                        "fecha" => "2000"
                        "volumen" => "121"
                        "paginaInicial" => "31"
                        "paginaFinal" => "36"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0480"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;P&#46; Levick"
                            1 => "J&#46;L&#46; Mclarty"
                            2 => "D&#46;B&#46; Murray"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/HYPERTENSIONAHA.108.123158"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2009"
                        "volumen" => "53"
                        "paginaInicial" => "1041"
                        "paginaFinal" => "1047"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19398662"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0485"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;F&#46; Reilly"
                            1 => "D&#46;A&#46; Tewksbury"
                            2 => "N&#46;M&#46; Schechter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "1982"
                        "volumen" => "257"
                        "paginaInicial" => "8619"
                        "paginaFinal" => "8622"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6807977"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0490"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Targeting cardiac mast cells&#58; pharmacological modulation of the local renin-angiotensin system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;C&#46; Reid"
                            1 => "J&#46;A&#46; Brazin"
                            2 => "C&#46; Morrey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Curr Pharm"
                        "fecha" => "2011"
                        "volumen" => "17"
                        "paginaInicial" => "3744"
                        "paginaFinal" => "3752"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0495"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Heritability of left ventricular mass&#58; The Framingham Heart Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "W&#46;S&#46; Post"
                            1 => "M&#46;G&#46; Larson"
                            2 => "R&#46;H&#46; Myers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.hyp.30.5.1025"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "1997"
                        "volumen" => "30"
                        "paginaInicial" => "1025"
                        "paginaFinal" => "1028"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9369250"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0500"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacogenetic approaches to hypertension therapy&#58; design and rationale for the Genetics of Hypertension Associated Treatment &#40;GenHAT&#41; study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46;K&#46; Arnett"
                            1 => "E&#46; Boerwinkle"
                            2 => "B&#46;R&#46; Davis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.tpj.6500113"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacogenomics J"
                        "fecha" => "2002"
                        "volumen" => "2"
                        "paginaInicial" => "309"
                        "paginaFinal" => "317"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12439737"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0505"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early markers of cardiovascular disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46;K&#46; Kapuku"
                            1 => "G&#46;A&#46; Harshfield"
                            2 => "H&#46;C&#46; Davis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Vasc Pharmacol"
                        "fecha" => "2006"
                        "volumen" => "45"
                        "paginaInicial" => "277"
                        "paginaFinal" => "280"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0510"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Integrated genomic approaches implicate osteoglycin &#40;Ogn&#41; in the regulation of left ventricular mass"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46;R&#46; Petretto"
                            1 => "R&#46; Sawar"
                            2 => "I&#46; Grieve"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng.134"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2008"
                        "volumen" => "40"
                        "paginaInicial" => "546"
                        "paginaFinal" => "552"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18443592"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0025619617300253"
                          "estado" => "S300"
                          "issn" => "00256196"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0515"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of leukocyte telomere length with echocardiographic left ventricular mass&#58; the Framingham heart study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;S&#46; Vasan"
                            1 => "S&#46; Demissie"
                            2 => "M&#46; Kimura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCULATIONAHA.109.853895"
                      "Revista" => array:7 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2009"
                        "volumen" => "120"
                        "paginaInicial" => "1195"
                        "paginaFinal" => "1202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19752323"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0168822717300669"
                          "estado" => "S300"
                          "issn" => "01688227"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0520"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mast cell tryptases and chymases in inflammation and host defense"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46;H&#46; Caughey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-065X.2007.00509.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Immunol Rev"
                        "fecha" => "2007"
                        "volumen" => "217"
                        "paginaInicial" => "141"
                        "paginaFinal" => "154"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17498057"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0525"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comportamento do peso do cora&#231;&#227;o e do corpo em chag&#225;sicos cr&#244;nicos com e sem &#8220;megas&#8221;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46;O&#46; Almeida"
                            1 => "V&#46;P&#46;A&#46; Teixeira"
                            2 => "W&#46;F&#46; Ara&#250;jo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Soc Bras Med Trop"
                        "fecha" => "1979"
                        "volumen" => "13"
                        "paginaInicial" => "85"
                        "paginaFinal" => "89"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0530"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlations between the collagen content of the human left ventricular myocardium&#44; measured by biochemical and morphometric methods"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;D&#46; Lopes"
                            1 => "R&#46;A&#46; Gomes"
                            2 => "V&#46; Hial"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arq Bras Cardiol"
                        "fecha" => "2002"
                        "volumen" => "79"
                        "paginaInicial" => "15"
                        "paginaFinal" => "19"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0535"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Quantitative methods in biology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;A&#46; Williams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "editores" => "A&#46;M&#46;Glaubert"
                        "titulo" => "Practical methods in electron microscopy&#46;"
                        "paginaInicial" => "233"
                        "serieFecha" => "1977"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0540"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The association of mast cells and atherosclerosis&#58; a morphologic study of early atherosclerotic lesions in young people"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;B&#46; Atkinson"
                            1 => "C&#46;W&#46; Harlan"
                            2 => "G&#46;C&#46; Harlan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Human Pathol"
                        "fecha" => "1994"
                        "volumen" => "25"
                        "paginaInicial" => "154"
                        "paginaFinal" => "159"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0545"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypertensive heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;A&#46; Diamond"
                            1 => "R&#46;A&#46; Phillips"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Hypertens Res"
                        "fecha" => "2005"
                        "volumen" => "28"
                        "paginaInicial" => "191"
                        "paginaFinal" => "202"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0550"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;F&#46; Jim&#233;nez-Navarro"
                            1 => "J&#46;J&#46; G&#243;mez-Doblas"
                            2 => "F&#46; Cabrera-Bueno"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Collagen synthesis and heart failure&#46; Rev Esp Cardiol &#40;Engl Ed&#41;"
                        "fecha" => "2005"
                        "volumen" => "58"
                        "paginaInicial" => "975"
                        "paginaFinal" => "978"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0555"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlation between mast cell density and myocardial fibrosis in congestive heart failure patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Batlle"
                            1 => "F&#46; P&#233;rez-Villa"
                            2 => "A&#46; L&#225;zaro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.transproceed.2007.06.047"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplant Proc"
                        "fecha" => "2007"
                        "volumen" => "39"
                        "paginaInicial" => "2347"
                        "paginaFinal" => "2349"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17889184"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0560"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46;C&#46; Goldsmith"
                            1 => "A&#46;D&#46; Bradshaw"
                            2 => "M&#46;R&#46; Zile"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Myocardial Fibroblast-Matrix Interactions and Potential Therapeutic Targets J Mol Cell Cardiol"
                        "fecha" => "2014"
                        "volumen" => "0"
                        "paginaInicial" => "92"
                        "paginaFinal" => "99"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0565"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Myocardial matrix remodeling and the matrix metalloproteinases&#58; influence on cardiac form and function"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46;G&#46; Spinale"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/physrev.00012.2007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Physiol Rev"
                        "fecha" => "2007"
                        "volumen" => "87"
                        "paginaInicial" => "1285"
                        "paginaFinal" => "1342"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17928585"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0570"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The progression of hypertensive heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;H&#46; Drazner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2011"
                        "volumen" => "123"
                        "paginaInicial" => "327"
                        "paginaFinal" => "334"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0575"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46; Peng"
                            1 => "Z&#46; Sarwar"
                            2 => "X&#46;P&#46; Yang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Profibrotic role for interleukin-4 in cardiac remodeling and dysfunction hypertension"
                        "fecha" => "2015"
                        "volumen" => "66"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0580"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Avalia&#231;&#227;o histol&#243;gica da fibrose card&#237;aca de indiv&#237;duos ur&#234;micos hipertensos&#58; estudo caso e controle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;C&#46; Jorge"
                            1 => "A&#46;J&#46; Mocelin"
                            2 => "T&#46; Matsuo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Bras Nefrol"
                        "fecha" => "2004"
                        "volumen" => "26"
                        "paginaInicial" => "190"
                        "paginaFinal" => "195"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0585"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biochemical assessment of myocardial fibrosis in hypertensive heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46; L&#243;pez"
                            1 => "A&#46; Gonz&#225;lez"
                            2 => "N&#46; Varo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/hy1101.098549"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2001"
                        "volumen" => "38"
                        "paginaInicial" => "1222"
                        "paginaFinal" => "1226"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11711527"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0590"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Procollagen type I carboxy-terminal peptide shows left ventricular hypertrophy and diastolic dysfunction in hypertensive patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Demir"
                            1 => "E&#46; Acarturk"
                            2 => "T&#46; Inal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.carpath.2006.09.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Pathol"
                        "fecha" => "2007"
                        "volumen" => "16"
                        "paginaInicial" => "69"
                        "paginaFinal" => "74"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17317538"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0595"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biochemical markers of myocardial remodelling in hypertensive heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Gonz&#225;lez"
                            1 => "B&#46; L&#243;pez"
                            2 => "S&#46; Ravassa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/cvr/cvn235"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Res"
                        "fecha" => "2009"
                        "volumen" => "81"
                        "paginaInicial" => "509"
                        "paginaFinal" => "518"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18762556"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0600"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Monocyte chemoattractant protein-1 enhances gene expression and synthesis of matrix metalloproteinase-1 in human fibroblasts by an autocrine IL-1 alpha loop"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46; Yamamoto"
                            1 => "B&#46; Eckes"
                            2 => "C&#46; Mauch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "2000"
                        "volumen" => "164"
                        "paginaInicial" => "6174"
                        "paginaFinal" => "6179"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0605"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46;L&#46; Gruber"
                            1 => "M&#46;J&#46; Marchese"
                            2 => "K&#46; Suzuki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI114344"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1989"
                        "volumen" => "84"
                        "paginaInicial" => "1657"
                        "paginaFinal" => "1662"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2553780"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0610"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mast cell proteinases activate precursor forms of collagenase and stromelysin&#44; but not of gelatinases A and B"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Lees"
                            1 => "D&#46;J&#46; Taylor"
                            2 => "D&#46;E&#46; Woolley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Biochem"
                        "fecha" => "1994"
                        "volumen" => "223"
                        "paginaInicial" => "171"
                        "paginaFinal" => "177"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0615"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Activation of precursors for matrix metalloproteinases 1 &#40;interstitial collagenase&#41; and 3 &#40;stromelysin&#41; by rat mast-cell proteinases I and II"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Suzuki"
                            1 => "M&#46; Lees"
                            2 => "G&#46;F&#46; Newlands"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1042/bj3050301"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochem J"
                        "fecha" => "1995"
                        "volumen" => "305"
                        "paginaInicial" => "301"
                        "paginaFinal" => "306"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7826345"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0620"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46; Thougounova"
                            1 => "A&#46; Lundequist"
                            2 => "I&#46; Fajardo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1074/jbc.M410396200"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "2005"
                        "volumen" => "280"
                        "paginaInicial" => "9291"
                        "paginaFinal" => "9296"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15615702"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0625"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46;M&#46; Heikkila"
                            1 => "S&#46; Latti"
                            2 => "M&#46;J&#46; Leskinen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/ATVBAHA.107.151340"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arterioscler Thromb Vasc Biol"
                        "fecha" => "2008"
                        "volumen" => "28"
                        "paginaInicial" => "309"
                        "paginaFinal" => "314"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18079408"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0630"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;P&#46; Hans"
                            1 => "Y&#46; Feng"
                            2 => "A&#46;S&#46; Naura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cardiovasc Pathol"
                        "fecha" => "2011"
                        "volumen" => "20"
                        "paginaInicial" => "e57"
                        "paginaFinal" => "e58"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0635"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46; Matsumoto"
                            1 => "A&#46; Wada"
                            2 => "T&#46; Tsutamoto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR.0000074041.81728.79"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2003"
                        "volumen" => "107"
                        "paginaInicial" => "2555"
                        "paginaFinal" => "2558"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12742989"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0640"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chymase inhibition reduces the progression to heart failure after autoimmune myocarditis in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;S&#46; Palaniyandi"
                            1 => "Y&#46; Nagai"
                            2 => "K&#46; Watanabe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Exp Biol Med"
                        "fecha" => "2007"
                        "volumen" => "232"
                        "paginaInicial" => "1213"
                        "paginaFinal" => "1221"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0645"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Isolation of functional cardiac immune cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;L&#46; McLarty"
                            1 => "G&#46;C&#46; Mel&#233;ndez"
                            2 => "W&#46;J&#46; Spencer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Vis Exp"
                        "fecha" => "2011"
                        "volumen" => "58"
                        "paginaInicial" => "3020"
                        "itemHostRev" => array:3 [
                          "pii" => "S0735109711019528"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0650"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;S&#46; Janicki"
                            1 => "G&#46;L&#46; Brower"
                            2 => "S&#46;P&#46; Levick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/978-1-4939-1568-2_8"
                      "Revista" => array:6 [
                        "tituloSerie" => "The Emerging Prominence of the Cardiac Mast Cell as a Potent Mediator of Adverse Myocardial Remodeling Methods Mol Biol"
                        "fecha" => "2015"
                        "volumen" => "1220"
                        "paginaInicial" => "121"
                        "paginaFinal" => "139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25388248"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0655"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vascular chymase&#58; pathophysiological role and therapeutic potential of inhibition"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;A&#46; Doggrell"
                            1 => "J&#46;C&#46; Wanstall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Casdiovasc Res"
                        "fecha" => "2004"
                        "volumen" => "61"
                        "paginaInicial" => "653"
                        "paginaFinal" => "662"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0660"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Integrated signalling pathways for mast-cell activation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;M&#46; Gilfillan"
                            1 => "C&#46; Tkaczyk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nat Rev"
                        "fecha" => "2006"
                        "volumen" => "6"
                        "paginaInicial" => "218"
                        "paginaFinal" => "230"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0665"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Functional effects of overexpression of protein kinase C-alpha&#44; -beta&#44; -delta -epsilon&#44; and -eta in the mast cell line RBL-2H3"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46;Y&#46; Chang"
                            1 => "Z&#46; Szallasi"
                            2 => "P&#46; Acs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "1997"
                        "volumen" => "159"
                        "paginaInicial" => "2624"
                        "paginaFinal" => "2632"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9300681"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0670"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mast cells and epsilonPKC&#58; a role in cardiac remodeling in hypertension-induced heart failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;S&#46; Palanyiandi"
                            1 => "K&#46; Inagaki"
                            2 => "D&#46; Mochly-Rosen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.yjmcc.2008.08.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Mol Cell Cardiol"
                        "fecha" => "2008"
                        "volumen" => "45"
                        "paginaInicial" => "779"
                        "paginaFinal" => "786"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18804478"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0675"
              "etiqueta" => "62"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Large Accumulation of Collagen and Increased Activation of Mast Cells in Hearts of Mice with Hyperlipidemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "Y&#46; Cheng"
                            1 => "Y&#46; Zhu"
                            2 => "J&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5935/abc.20170143"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arq Bras Cardiol"
                        "fecha" => "2017"
                        "volumen" => "109"
                        "paginaInicial" => "404"
                        "paginaFinal" => "409"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28977053"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib0680"
              "etiqueta" => "63"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prehypertension and black-white contrasts in cardiovascular risk in young adults&#58; Bogalusa Heart Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Toprak"
                            1 => "H&#46; Wang"
                            2 => "W&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/hjh.0b013e32831aeee3"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "paginaInicial" => "243"
                        "paginaFinal" => "250"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19226697"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib0685"
              "etiqueta" => "64"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Family history of hypertension and arterial elasticity characteristics in healthy young people"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46; Zhou"
                            1 => "C&#46; Yuanyuan"
                            2 => "S&#46; Ningling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1291/hypres.31.833"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertens Res"
                        "fecha" => "2008"
                        "volumen" => "31"
                        "paginaInicial" => "833"
                        "paginaFinal" => "839"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18712037"
                             …1
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib0690"
              "etiqueta" => "65"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fatores determinantes e mecanismos moleculares"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arq Bras Cardiol"
                        "fecha" => "1995"
                        "volumen" => "65"
                        "paginaInicial" => "533"
                        "paginaFinal" => "539"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib0695"
              "etiqueta" => "66"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beneficial effects of estrogen treatment in the HLA B27 transgenic rat model of inflammatory bowel disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Physiol Gastrointest Liver Physiol"
                        "fecha" => "2004"
                        "volumen" => "286"
                        "paginaInicial" => "118"
                        "paginaFinal" => "125"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib0700"
              "etiqueta" => "67"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Existe evid&#234;ncia para tratar insufici&#234;ncia card&#237;aca baseada na ra&#231;a ou etnia&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/s0104-42302009000200010"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Assoc Med Bras"
                        "fecha" => "2009"
                        "volumen" => "55"
                        "paginaInicial" => "110"
                        "paginaFinal" => "116"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            67 => array:3 [
              "identificador" => "bib0705"
              "etiqueta" => "68"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ra&#231;a e hipertrofia do ventr&#237;culo esquerdo na aus&#234;ncia de hipertens&#227;o e de doen&#231;as cardiopulmonares"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arq Bras Cardiol"
                        "fecha" => "1994"
                        "volumen" => "62"
                        "paginaInicial" => "413"
                        "paginaFinal" => "416"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            68 => array:3 [
              "identificador" => "bib0710"
              "etiqueta" => "69"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left ventricular hypertrophy in black and white hypertensives Standard electrographic criteria overestimate racial differences in prevalence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1992"
                        "volumen" => "267"
                        "paginaInicial" => "3294"
                        "paginaFinal" => "3299"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0167527316332764"
                          "estado" => "S300"
                          "issn" => "01675273"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            69 => array:3 [
              "identificador" => "bib0715"
              "etiqueta" => "70"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypertensive vascular disease as a cause of death in blacks versus whites&#58; autopsy findings in 587 adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.hyp.31.5.1070"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "1998"
                        "volumen" => "31"
                        "paginaInicial" => "1070"
                        "paginaFinal" => "1076"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            70 => array:3 [
              "identificador" => "bib0720"
              "etiqueta" => "71"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ra&#231;a e les&#227;o de &#243;rg&#227;os-alvo da hipertens&#227;o arterial em pacientes atendidos em um ambulat&#243;rio universit&#225;rio de refer&#234;ncia na cidade de Salvador"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arq Bras Cardiol"
                        "fecha" => "2004"
                        "volumen" => "82"
                        "paginaInicial" => "111"
                        "paginaFinal" => "115"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            71 => array:3 [
              "identificador" => "bib0725"
              "etiqueta" => "72"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Examining racial and ethnic disparities in health and hypertension control"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1370/afm.927"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Fam Med"
                        "fecha" => "2008"
                        "volumen" => "6"
                        "paginaInicial" => "483"
                        "paginaFinal" => "485"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            72 => array:3 [
              "identificador" => "bib0730"
              "etiqueta" => "73"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fibrosis and hypertensive heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Curr Opin Cardiol"
                        "fecha" => "2000"
                        "volumen" => "1513"
                        "paginaInicial" => "264"
                        "paginaFinal" => "272"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/08702551/0000003900000002/v1_202005070648/S0870255120300810/v1_202005070648/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "29261"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Artigos Originais"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08702551/0000003900000002/v1_202005070648/S0870255120300810/v1_202005070648/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255120300810?idApp=UINPBA00004E"
]
Partilhar
Informação da revista

Estatísticas

Siga este link para acessar o texto completo do artigo

Original Article
Analysis of mast cells and myocardial fibrosis in autopsied patients with hypertensive heart disease
Análise dos mastócitos e fibrose miocárdica em pacientes autopsiados com cardiopatia hipertensiva
Guilherme Ribeiro Julianoa,
Autor para correspondência
guiribeiro85@yahoo.com.br

Corresponding author.
, Mariana Fleury Skafa, Luciana Santos Ramalhoa, Gabriela Ribeiro Julianoa, Bianca Gonçalves Silva Torquatoa, Mariana Silva Oliveiraa, Flávia Aparecida Oliveirab, Ana Paula Espíndulaa, Camila Lourencini Cavellania, Vicente de Paula Antunes Teixeiraa, Mara Lúcia da Fonseca Ferraza
a General Pathology Department, Biological and Natural Sciences Institute (ICBN), Federal University of Triângulo Mineiro (UFTM), Uberaba, MG, Brazil
b Institute of Tropical Pathology and Public Health (IPTSP), Federal University of Goiás (UFG), Goiânia, GO, Brazil
Lido
3731
Vezes
que se leu este artigo
1466
Total PDF
2265
Total HTML
Compartilhar estatísticas
 array:26 [
  "pii" => "S0870255120300810"
  "issn" => "08702551"
  "doi" => "10.1016/j.repc.2019.11.003"
  "estado" => "S300"
  "fechaPublicacion" => "2020-02-01"
  "aid" => "1497"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2020"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Cardiol. 2020;39:89-96"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "en" => array:20 [
      "pii" => "S2174204920301380"
      "issn" => "21742049"
      "doi" => "10.1016/j.repce.2020.05.006"
      "estado" => "S300"
      "fechaPublicacion" => "2020-02-01"
      "aid" => "1503"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "dis"
      "cita" => "Rev Port Cardiol. 2020;39:97-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
        "titulo" => "Mast cells&#58; Promoters of myocardial fibrosis in hypertensive heart disease&#63;"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "97"
            "paginaFinal" => "98"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "Mast&#243;citos&#58; promotores da fibrose mioc&#225;rdica na doen&#231;a hipertensiva card&#237;aca&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Rosa Henriques de Gouveia"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "Rosa Henriques de"
                "apellidos" => "Gouveia"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0870255120300871"
          "doi" => "10.1016/j.repc.2020.03.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255120300871?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204920301380?idApp=UINPBA00004E"
      "url" => "/21742049/0000003900000002/v1_202005210836/S2174204920301380/v1_202005210836/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S0870255120300871"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2020.03.004"
    "estado" => "S300"
    "fechaPublicacion" => "2020-02-01"
    "aid" => "1503"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "dis"
    "cita" => "Rev Port Cardiol. 2020;39:97-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
      "titulo" => "Mast cells&#58; Promoters of myocardial fibrosis in hypertensive heart disease&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "97"
          "paginaFinal" => "98"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Mast&#243;citos&#58; promotores da fibrose mioc&#225;rdica na doen&#231;a hipertensiva card&#237;aca&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rosa Henriques de Gouveia"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Rosa Henriques de"
              "apellidos" => "Gouveia"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2174204920301380"
        "doi" => "10.1016/j.repce.2020.05.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204920301380?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255120300871?idApp=UINPBA00004E"
    "url" => "/08702551/0000003900000002/v1_202005070648/S0870255120300871/v1_202005070648/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S0870255120300883"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2020.03.005"
    "estado" => "S300"
    "fechaPublicacion" => "2020-02-01"
    "aid" => "1504"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "dis"
    "cita" => "Rev Port Cardiol. 2020;39:85-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
      "titulo" => "Tobacco use&#58; More needs to be done to control active and passive smoking"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "85"
          "paginaFinal" => "87"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Consumo de tabaco - para controlar o tabagismo ativo e passivo &#233; neces&#225;rio fazer mais"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Evangelista Rocha"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Evangelista"
              "apellidos" => "Rocha"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2174204920301367"
        "doi" => "10.1016/j.repce.2020.05.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204920301367?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255120300883?idApp=UINPBA00004E"
    "url" => "/08702551/0000003900000002/v1_202005070648/S0870255120300883/v1_202005070648/en/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:20 [
      "pii" => "S0870255120300871"
      "issn" => "08702551"
      "doi" => "10.1016/j.repc.2020.03.004"
      "estado" => "S300"
      "fechaPublicacion" => "2020-02-01"
      "aid" => "1503"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "dis"
      "cita" => "Rev Port Cardiol. 2020;39:97-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
        "titulo" => "Mast cells&#58; Promoters of myocardial fibrosis in hypertensive heart disease&#63;"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "97"
            "paginaFinal" => "98"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "Mast&#243;citos&#58; promotores da fibrose mioc&#225;rdica na doen&#231;a hipertensiva card&#237;aca&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Rosa Henriques de Gouveia"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "Rosa Henriques de"
                "apellidos" => "Gouveia"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2174204920301380"
          "doi" => "10.1016/j.repce.2020.05.006"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204920301380?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255120300871?idApp=UINPBA00004E"
      "url" => "/08702551/0000003900000002/v1_202005070648/S0870255120300871/v1_202005070648/en/main.assets"
    ]
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
    "titulo" => "Analysis of mast cells and myocardial fibrosis in autopsied patients with hypertensive heart disease"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "89"
        "paginaFinal" => "96"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Guilherme Ribeiro Juliano, Mariana Fleury Skaf, Luciana Santos Ramalho, Gabriela Ribeiro Juliano, Bianca Gon&#231;alves Silva Torquato, Mariana Silva Oliveira, Fl&#225;via Aparecida Oliveira, Ana Paula Esp&#237;ndula, Camila Lourencini Cavellani, Vicente de Paula Antunes Teixeira, Mara L&#250;cia da Fonseca Ferraz"
        "autores" => array:11 [
          0 => array:4 [
            "nombre" => "Guilherme Ribeiro"
            "apellidos" => "Juliano"
            "email" => array:1 [
              0 => "guiribeiro85@yahoo.com.br"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Mariana Fleury"
            "apellidos" => "Skaf"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Luciana Santos"
            "apellidos" => "Ramalho"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Gabriela Ribeiro"
            "apellidos" => "Juliano"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Bianca Gon&#231;alves Silva"
            "apellidos" => "Torquato"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Mariana Silva"
            "apellidos" => "Oliveira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Fl&#225;via Aparecida"
            "apellidos" => "Oliveira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Ana Paula"
            "apellidos" => "Esp&#237;ndula"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "Camila Lourencini"
            "apellidos" => "Cavellani"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          9 => array:3 [
            "nombre" => "Vicente de Paula Antunes"
            "apellidos" => "Teixeira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          10 => array:3 [
            "nombre" => "Mara L&#250;cia da Fonseca"
            "apellidos" => "Ferraz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "General Pathology Department&#44; Biological and Natural Sciences Institute &#40;ICBN&#41;&#44; Federal University of Tri&#226;ngulo Mineiro &#40;UFTM&#41;&#44; Uberaba&#44; MG&#44; Brazil"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Institute of Tropical Pathology and Public Health &#40;IPTSP&#41;&#44; Federal University of Goi&#225;s &#40;UFG&#41;&#44; Goi&#226;nia&#44; GO&#44; Brazil"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "An&#225;lise dos mast&#243;citos e fibrose mioc&#225;rdica em pacientes autopsiados com cardiopatia hipertensiva"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1076
            "Ancho" => 1422
            "Tamanyo" => 68725
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Correlation between collagen fibers and density of mast cells immunolabeled with anti-tryptase antibodies&#46; Linear regression fit<span class="elsevierStyleMonospace">&#61;</span>2&#46;96<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>0&#46;21&#46; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;02&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0010" class="elsevierStylePara elsevierViewall">Cardiovascular disease is the leading cause of mortality worldwide&#44; and in Brazil is responsible for about 20&#37; of all deaths in people over 30 years of age&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">1</span></a> There has been a change in recent years of the main causes of morbidity and mortality from infectious diseases to cardiovascular disease&#44; cancer&#44; and other chronic diseases&#44; such as systemic hypertension &#40;the epidemiological transition&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">2&#8211;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">One of the consequences of untreated systemic hypertension&#44; which induces cardiac lesions and left ventricular &#40;LV&#41; hypertrophy&#44; is hypertensive heart disease&#46; A new component of the pathophysiology of hypertensive heart disease has been described&#58; apoptosis of cardiomyocytes and changes in collagen synthesis and degradation&#44; which may play an important role in the development of LV hypertrophy and myocardial injury&#46;<a class="elsevierStyleCrossRefs" href="#bib0395"><span class="elsevierStyleSup">6&#8211;8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Studies have shown that chronic LV overload increases the density of cardiac mast cells&#44; which when activated release a range of potent inflammatory and pro-fibrotic mediators that play an active part in cardiac remodeling&#46;<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The mechanisms underlying progression of collagen deposition and fibrosis as a result of the presence of cardiac mast cells have not been fully elucidated&#46; Therefore&#44; the purpose of this study was to assess the formation of collagen fibers and mast cell density in hypertensive heart disease&#44; in order to improve our understanding of the pathological processes involved&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Hypothesis</span><p id="par0040" class="elsevierStylePara elsevierViewall">We hypothesize that mast cells are involved in the development of hypertensive heart disease&#44; contributing to the remodeling of collagen fibers in this disease&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Background</span><p id="par0045" class="elsevierStylePara elsevierViewall">Experimental studies have reported that cardiac mast cells are involved in myocardial fibrosis&#46; The first to describe this association were Olivetti et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">11</span></a> who observed an increase in cardiac mast cells in the right ventricle of rats with pulmonary artery stenosis&#44; although they did not indicate whether the mast cells were associated with fibrosis&#46; Panizo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">12</span></a> first investigated mast cells in the left ventricle in systemic hypertension&#44; and noted a strong correlation between increased mast cell density and increased collagen&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Activated cardiac mast cells release a number of potent inflammatory and pro-fibrotic mediators&#44; including cytokines&#44; chemokines&#44; and proteases&#46; They can be activated by immunoglobulin E&#44; by factors and histamine released by neighboring macrophages or T lymphocytes&#44; or by components of the complement system &#40;C3a and C5a&#41;&#46; Once activated&#44; they initiate degranulation&#44; which is the process of exocytosis of the components of their granules&#46;<a class="elsevierStyleCrossRefs" href="#bib0430"><span class="elsevierStyleSup">13&#44;14</span></a> Other factors that activate cardiac mast cells have not been clearly identified&#44; but endothelin-1&#44; reactive oxygen species&#44; substance P and interleukin &#40;IL&#41;-33 appear to be involved in the process&#46;<a class="elsevierStyleCrossRefs" href="#bib0415"><span class="elsevierStyleSup">10&#44;15&#8211;17</span></a> The most abundant proteins stored in the secretory granules of mast cells are endopeptidases&#44; of which the most important are tryptase and chymase&#46; Both are serine proteases&#44; but they differ in activity and in expression patterns&#46;<a class="elsevierStyleCrossRefs" href="#bib0455"><span class="elsevierStyleSup">18&#44;19</span></a> Mast cells maturing in microenvironments of different tissues may vary in the type and amount of tryptase and chymase expressed&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The physiological role of tryptase and chymase is still unclear and their activity is observed not in normal tissues&#44; but in tissues with lesions&#46; Tryptase is the predominant enzyme in the granules&#46;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">20</span></a> Human mast cells that contain tryptase in their granules express protease-activated receptor 2 &#40;PAR-2&#41;&#46; In vitro studies have shown that pretreatment of these cells with the PAR-2 activating peptide upregulates IL-8 &#40;CXCL8&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">21</span></a> Incubation of tryptase in endothelial cell cultures induces neutrophil migration&#44; which is dependent on IL-8&#46;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">22</span></a> Another study demonstrated that incubation of cardiac fibroblasts with tryptase resulted in collagen proliferation and synthesis&#46;<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">23</span></a> It has been shown that chymase is able to convert angiotensin I into angiotensin II<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">24</span></a> and is probably involved in structural remodeling associated with diseases of the cardiovascular system&#46;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">18</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">It is clear that mast cells play an important role in various cardiac diseases&#44; but due to the complex composition of the secretory granules and the plasticity of their phenotype&#44; their contribution remains to be clarified&#46;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">25</span></a> Molecular studies have been proposed in order to characterize the key genes involved in the modulation of these pathological processes&#44; but they are still in their early stages and their findings cannot as yet be used in clinical practice&#46;<a class="elsevierStyleCrossRefs" href="#bib0495"><span class="elsevierStyleSup">26&#8211;30</span></a> Since mast cells express some peptidases at high levels&#44; immunohistochemistry and immunoassays using antibodies directed against these enzymes are experimentally useful to assess numbers of mast cells&#44; their activation sites and associated diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">31</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Methods</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Sample collection</span><p id="par0065" class="elsevierStylePara elsevierViewall">Fragments were collected from the middle third of the LV free wall from 30 individuals autopsied by two pathologists at the Clinical Hospital of the Federal University of Tri&#226;ngulo Mineiro &#40;UFTM&#41;&#44; between 1987 and 2017&#46; The autopsy protocols were analyzed to obtain data including age&#44; gender&#44; race&#44; heart weight and body weight&#46; Samples from individuals aged 18 or older were selected and then divided into two groups&#58; those with hypertensive heart disease &#40;HD&#41; &#40;n<span class="elsevierStyleMonospace">&#61;</span>15&#41; and those with no heart disease &#40;ND&#41; &#40;n<span class="elsevierStyleMonospace">&#61;</span>15&#41;&#46; Cases with an incomplete autopsy report and individuals with Chagas disease or any other heart disease were excluded from the study&#46; The ratio of heart weight &#40;g&#41; to body weight &#40;g&#41;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>100&#44; used in the definition of cardiac hypertrophy&#44; was calculated in all cases&#46;<a class="elsevierStyleCrossRef" href="#bib0525"><span class="elsevierStyleSup">32</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Sample preparation</span><p id="par0070" class="elsevierStylePara elsevierViewall">The LV fragments had been fixed in 10&#37; formaldehyde&#46; They were first dehydrated in alcohols of increasing concentration &#40;70-100&#37;&#41;&#44; cleared in xylene and embedded in paraffin&#46;<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">33</span></a> They were then cut into 4-&#956;m sections and slide 1 was stained with picrosirius red&#44; counter-colored with hematoxylin&#44; for quantification of collagen fibers&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Morphometric analysis of collagen fibers</span><p id="par0075" class="elsevierStylePara elsevierViewall">The number of fields for assessment and quantification of collagen fibers in the left ventricle was defined by the test of cumulative means&#46;<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">34</span></a> The histological section was divided into four quadrants and 40 fields of each fragment were digitized&#46; Under polarized light the area of collagen fibers had a birefringent appearance&#44; ranging from greenish yellow to reddish orange &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figures 1</a>A and B&#41;&#46; The collagen fibers were marked by the observer to obtain the percentage of collagen per field&#46; The quantified image field was then scanned by a camera attached to the microscope&#46; The morphometric analysis was performed using a LeicaQWin&#174; Plus image analyzer &#40;Leica Microsystems&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Immunohistochemical analysis</span><p id="par0080" class="elsevierStylePara elsevierViewall">Slides 2 and 3 were used for immunohistochemical analysis to determine positivity to anti-human mast cell chymase antibodies &#40;Diagnostic BioSystems&#174;&#41; diluted to 1&#58;2000 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figures 1</a>C and D&#41; and anti-human mast cell tryptase antibodies &#40;Diagnostic BioSystems&#174;&#41; diluted to 1&#58;500 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figures 1</a>E and F&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">35</span></a> Immunostained mast cells were quantified using a video camera connected to a conventional light microscope and to a computer with AxioVision&#174; Rel 4&#46;9&#46;1 image analysis software &#40;Carl Zeiss&#41;&#46; Mast cells were quantified along the length of the section using a final magnification of 500<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>in a microscope field of 0&#46;1520 mm<span class="elsevierStyleSup">2</span>&#46; The fragments were divided into four quadrants and&#44; in each quadrant&#44; ten randomly selected fields were quantified&#46; The density of mast cells in each fragment was determined by dividing the total number of mast cells in the 40 quantified fields by the total area of the field&#44; expressed in mast cells&#47;mm<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">2</span></a>&#46;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">18</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Statistical analysis</span><p id="par0085" class="elsevierStylePara elsevierViewall">The data were analyzed using GraphPad Prism&#174; 5 software &#40;GraphPad Software&#41;&#46; The Shapiro-Wilk test was applied to test for normality of distribution of variables&#46; The Student&#39;s t test &#40;t&#41; was used to compare groups for normally distributed variables and the Mann-Whitney U test for non-normal distributions&#46; The correlation between two variables with normal distribution was analyzed using Pearson&#39;s test &#40;r&#41;&#44; and for those presenting non-normal variance&#44; Spearman&#39;s test was used&#46; Differences were considered statistically significant for p&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Ethical considerations</span><p id="par0090" class="elsevierStylePara elsevierViewall">This study was approved by the Research Ethics Committee of the Federal University of Tri&#226;ngulo Mineiro through protocol no&#46; 1373&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Results</span><p id="par0095" class="elsevierStylePara elsevierViewall">Regarding the general characteristics of the sample&#44; the mean age of individuals in the HD group was 49&#46;8&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;2 years&#44; ranging from 44 to 66 years&#44; and in the ND group the mean age was 55&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;9 years&#44; ranging from 45 to 80 years&#46; With regard to gender&#44; 17 individuals &#40;56&#46;6&#37;&#41; were male and 13 &#40;43&#46;3&#37;&#41; were female&#46; Considering race&#44; 19 individuals &#40;63&#46;3&#37;&#41; were white and 11 &#40;36&#46;6&#37;&#41; were non-white&#46; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">When the HD and ND groups were compared&#44; a significantly higher percentage of collagen fibers in the left ventricle was seen in the HD group compared to the ND group &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;003&#41;&#46; Mast cell density was also significantly higher in LV samples from individuals with HD immunolabeled with anti-chymase and anti-tryptase antibodies &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;02&#41; and also in samples immunolabeled only with anti-tryptase antibodies &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;03&#41;&#46; Heart weight was also significantly greater in HD compared to ND &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Analyzing the HD group&#44; there was a significant positive correlation between the percentage of collagen fibers in the left ventricle and the density of mast cells immunolabeled with anti-chymase and anti-tryptase antibodies &#40;r<span class="elsevierStyleMonospace">&#61;</span>0&#46;517&#44; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;04&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41; and also those immunolabeled only with anti-tryptase antibodies &#40;r<span class="elsevierStyleMonospace">&#61;</span>0&#46;574&#44; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;02&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>&#41;&#46; There was no significant correlation between the percentage of collagen fibers in the left ventricle and mast cell density in the ND group &#40;data not shown&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">There was no significant difference between percentage of collagen fibers&#44; mast cell density and heart weight in terms of gender&#44; race or age in either group&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discussion</span><p id="par0115" class="elsevierStylePara elsevierViewall">Systemic hypertension leads to structural and functional changes in the heart&#46;<a class="elsevierStyleCrossRef" href="#bib0545"><span class="elsevierStyleSup">36</span></a> In our study&#44; we found an increase in collagen fibers in the HD group compared to the ND group&#46; This finding is in line with the literature&#44; which reports that fibrosis is among the morphological changes most often found in patients with hypertensive heart disease&#46; It is characterized by diffuse or excessive accumulation of collagen fibers and increasing myocardial stiffness&#44; which can lead to LV dysfunction and&#44; eventually&#44; heart failure&#46;<a class="elsevierStyleCrossRefs" href="#bib0550"><span class="elsevierStyleSup">37&#8211;39</span></a> This reactive fibrosis is characteristic of pathological processes that trigger myocardial hypertrophy&#46;<a class="elsevierStyleCrossRefs" href="#bib0395"><span class="elsevierStyleSup">6&#44;40</span></a> The mechanisms responsible for the progression of LV hypertrophy include not only response to mechanical stress&#44; but also the influence of neurohormones&#44; growth factors and cytokines&#46;<a class="elsevierStyleCrossRefs" href="#bib0570"><span class="elsevierStyleSup">41&#44;42</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Another study on the quantification of collagen in autopsied hearts of hypertensive and non-hypertensive individuals showed increased collagen in hypertensive patients with LV hypertrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">43</span></a> This finding is in agreement with our research&#46; Other studies have shown that type I collagen metabolism is increased in both humans and mice with hypertensive heart disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0585"><span class="elsevierStyleSup">44&#44;45</span></a> Research has shown a close relationship between non-invasive histological diagnosis of myocardial fibrosis in animals and hypertensive patients and biochemical markers such as the carboxy-terminal propeptide of procollagen type I&#46;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">37</span></a> Serum levels of this propeptide were higher in patients with hypertensive heart disease than in those with no heart disease&#44;<a class="elsevierStyleCrossRef" href="#bib0595"><span class="elsevierStyleSup">46</span></a> showing that the precursors of collagen synthesis are increased in individuals affected by hypertensive heart disease&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">It has also been demonstrated that the ratio of serum matrix metalloproteinase &#40;MMP&#41;-1 and its tissue inhibitors is altered in patients with hypertensive heart disease&#44;<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">47</span></a> and that patients with reduced ejection fraction due to LV chamber dilatation present changes in the distribution of collagen fibers&#44; mainly perivascular and scar&#44; and considerable increases in MMP-1&#46;<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">40</span></a> These findings are related to the results of the present study&#44; as activated MMPs are the main mediators of myocardial remodeling&#44; mainly through the release of tryptase&#44; which cleaves the pro-MMP-3 precursor&#44; activating MMP-3 which then activates MMP-1&#44; and through the release of chymase&#44; which activates MMP-2 and MMP-9&#46;<a class="elsevierStyleCrossRefs" href="#bib0605"><span class="elsevierStyleSup">48&#8211;53</span></a> This remodeling appears to be critical to the progression of LV hypertrophy&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">In the present study&#44; we found a significant increase in the density of mast cells in the left ventricle of individuals with hypertensive heart disease&#46; Experimental studies that help explain our results demonstrated increased mast cell density in LV overload conditions and myocardial remodeling&#46;<a class="elsevierStyleCrossRefs" href="#bib0445"><span class="elsevierStyleSup">16&#44;23&#44;50</span></a> The products of mast cell degranulation&#44; besides activating the innate immune system&#44; are pro-inflammatory&#44; pro-fibrogenic and pro-hypertrophic&#46; Among them are transforming growth factor beta &#40;TGF-&#946;&#41;&#44; histamine&#44; chymase&#44; tryptase&#44; IL-4 and tumor necrosis factor alpha&#44;<a class="elsevierStyleCrossRefs" href="#bib0575"><span class="elsevierStyleSup">42&#44;54&#8211;58</span></a> which correlates with the significant increase in collagen fibers in the left ventricle of patients with hypertensive heart disease&#46; It is established in the literature that protein kinase C &#40;PKC&#41; is a convergence point for these events&#46;<a class="elsevierStyleCrossRef" href="#bib0660"><span class="elsevierStyleSup">59</span></a> Although in vitro studies have implicated PKC in mast cell degranulation&#44; this has not been demonstrated in in vivo studies using heart failure models&#46;<a class="elsevierStyleCrossRef" href="#bib0665"><span class="elsevierStyleSup">60</span></a> In a study on hypertensive rats&#44; it was demonstrated that inhibition of the PKC pathway attenuated mast cell degranulation without affecting mast cell density&#46; This treatment also inhibited the infiltration of inflammatory cells&#44; vasculopathy and fibrosis in the myocardium&#46;<a class="elsevierStyleCrossRef" href="#bib0670"><span class="elsevierStyleSup">61</span></a> Another study in rats with hyperlipidemia using Western blot analysis and immunohistochemical staining demonstrated that protein expression of TGF-&#946; in the hearts of hyperlipidemic rats was significantly higher than in the control group&#46;<a class="elsevierStyleCrossRef" href="#bib0675"><span class="elsevierStyleSup">62</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">The lower percentage of collagen fibers and mast cell density in the left ventricle of women with hypertensive heart disease was not significant&#59; however&#44; this was also an expected result&#46; The prevalence of prehypertension and hypertension in the literature is lower in women than in men&#46;<a class="elsevierStyleCrossRef" href="#bib0680"><span class="elsevierStyleSup">63</span></a> It appears that women suffer less effects from hypertension than men&#44; due &#8211; among other factors &#8211; to the protective effects of endogenous estrogen&#46;<a class="elsevierStyleCrossRef" href="#bib0685"><span class="elsevierStyleSup">64</span></a> Bearing in mind the mean age of 54 years of the women analyzed&#44; according to a study that reports that cardiac hypertrophy is more prevalent in menopausal women as a result of reduced levels of cardioprotective female sex hormones&#44;<a class="elsevierStyleCrossRef" href="#bib0690"><span class="elsevierStyleSup">65</span></a> these hormones also suppress the action of MMPs by reducing levels of cytokines such as TNF-&#945;<a class="elsevierStyleCrossRef" href="#bib0695"><span class="elsevierStyleSup">66</span></a> that control the activation of mast cells&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">With regards to race&#44; although non-white subjects had higher percentages of collagen fibers&#44; the relationship between hypertensive heart disease and skin color is controversial&#46; The ethnically mixed nature of the Brazilian population makes race a criterion of lesser validity for assessing the risk of developing heart disease&#46;<a class="elsevierStyleCrossRef" href="#bib0700"><span class="elsevierStyleSup">67</span></a> An autopsy study found that LV hypertrophy was not more prevalent in black patients&#44;<a class="elsevierStyleCrossRef" href="#bib0705"><span class="elsevierStyleSup">68</span></a> but in this study hypertension was an exclusion criterion&#44; unlike our study&#44; in which some subjects were hypertensive&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Studies have shown a relationship between severity and duration of hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0710"><span class="elsevierStyleSup">69</span></a> It has also been suggested that genetic control of ventricular mass may differ in different ethnic groups&#46;<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">27</span></a> Other studies have presented evidence to suggest that LV hypertrophy contributes to a higher frequency of sudden death&#44; especially among black patients&#46;<a class="elsevierStyleCrossRef" href="#bib0715"><span class="elsevierStyleSup">70</span></a> Systemic hypertension is one of the main causes of disparities in mortality rates between blacks and whites in the USA&#44; due to differences in prevalence and control&#46; Other data suggest that primary care and social and environmental conditions reinforce this disparity in the prevalence of severe hypertension among blacks and whites&#46;<a class="elsevierStyleCrossRefs" href="#bib0700"><span class="elsevierStyleSup">67&#44;71&#44;72</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">In our study&#44; there was a non-significant increase in the percentage of collagen fibers with age&#46; This finding may be due to the severity of systemic hypertension&#44; since the mean age of the individuals analyzed in the study was 49&#46;8 years in patients with hypertensive heart disease&#46;<a class="elsevierStyleCrossRef" href="#bib0730"><span class="elsevierStyleSup">73</span></a></p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conclusions</span><p id="par0155" class="elsevierStylePara elsevierViewall">Our study showed that&#44; in patients with hypertensive heart disease&#44; there is an increase in collagen fibers in the left ventricle&#46; This reactive fibrosis is a fundamental component of the process of myocardial hypertrophy&#46; The increase in the density of mast cells in the left ventricle of patients with hypertensive heart disease observed in the study indicates that mast cells have an important role in myocardial remodeling in hypertensive heart disease&#46; Additional studies will help elucidate the mechanisms of collagen turnover&#44; so that therapeutic targets may be determined in order to regulate the actions of the main proteases released in the activation of mast cells&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Funding</span><p id="par0160" class="elsevierStylePara elsevierViewall">The present study was supported by the National Council for Scientific and Technological Development &#40;<span class="elsevierStyleItalic">Conselho Nacional de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico</span>&#44; CNPq&#41;&#44; Coordination of Improvement of Higher Education Personnel &#40;<span class="elsevierStyleItalic">Coordena&#231;&#227;o de Aperfei&#231;oamento de Pessoal de N&#237;vel Superior</span>&#44; CAPES&#41;&#44; the Foundation for Research Support of the State of Minas Gerais &#40;<span class="elsevierStyleItalic">Funda&#231;&#227;o de Amparo &#224; Pesquisa do Estado de Minas Gerais</span>&#44; FAPEMIG&#41; and the Foundation Of Teaching and Research of Uberaba &#40;<span class="elsevierStyleItalic">Funda&#231;&#227;o de Ensino e Pesquisa de Uberaba</span>&#44; FUNEPU&#41;&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conflicts of interest</span><p id="par0165" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interests to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:14 [
        0 => array:3 [
          "identificador" => "xres1333277"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Objective"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1228378"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres1333276"
          "titulo" => "Resumo"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Objetivo"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclus&#245;es"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1228379"
          "titulo" => "Palavras-chave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Hypothesis"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Background"
        ]
        7 => array:3 [
          "identificador" => "sec0020"
          "titulo" => "Methods"
          "secciones" => array:6 [
            0 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Sample collection"
            ]
            1 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Sample preparation"
            ]
            2 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Morphometric analysis of collagen fibers"
            ]
            3 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Immunohistochemical analysis"
            ]
            4 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Statistical analysis"
            ]
            5 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Ethical considerations"
            ]
          ]
        ]
        8 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Results"
        ]
        9 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Discussion"
        ]
        10 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conclusions"
        ]
        11 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Funding"
        ]
        12 => array:2 [
          "identificador" => "sec0075"
          "titulo" => "Conflicts of interest"
        ]
        13 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2017-11-13"
    "fechaAceptado" => "2019-11-02"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1228378"
          "palabras" => array:3 [
            0 => "Autopsy"
            1 => "Hypertensive heart disease"
            2 => "Mast cells"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec1228379"
          "palabras" => array:3 [
            0 => "Autopsia"
            1 => "Cardiopatia hipertensiva"
            2 => "Mast&#243;citos"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To analyze the percentage of collagen fibers and mast cell density in the left ventricular myocardium of autopsied patients with and without hypertensive heart disease&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Thirty fragments of left ventricular myocardium were obtained from individuals autopsied at the Clinical Hospital of the Federal University of Tri&#226;ngulo Mineiro &#40;UFTM&#41; in the period from 1987 to 2017&#46; Individuals were divided into two groups&#58; those with hypertensive heart disease &#40;HD&#41; and those with no heart disease &#40;ND&#41;&#46; Subjects were also assessed according to age&#44; gender and race &#40;white and non-white&#41;&#46; Collagen fibers were quantified by computed morphometry and mast cell density was assessed by immunohistochemical methods&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">There were significantly more collagen fibers in the left ventricle in the HD group than in the ND group &#40;p&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Mast cell density was significantly higher in the left ventricle of individuals with HD immunolabeled with anti-chymase and anti-tryptase antibodies &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;02&#41; and also of those immunolabeled only with anti-tryptase antibodies &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;03&#41;&#46; Analyzing the HD group&#44; there was a significant positive correlation between the percentage of collagen fibers in the left ventricle and mast cell density immunolabeled by anti-chymase and anti-tryptase antibodies &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;04&#41; and also mast cell density immunolabeled only with anti-tryptase antibodies &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#46;02&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Mast cells are involved in the development of hypertensive heart disease&#44; contributing to the remodeling of collagen fibers in this disease&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objective"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "pt" => array:3 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Analisar a porcentagem de fibras col&#225;genas e a densidade mastocit&#225;ria no mioc&#225;rdio ventricular esquerdo de pacientes autopsiados com e sem cardiopatia hipertensiva&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Foram obtidos 30 fragmentos do mioc&#225;rdio ventricular esquerdo de indiv&#237;duos autopsiados no Hospital Cl&#237;nico da Universidade Federal do Tri&#226;ngulo Mineiro &#40;UFTM&#41; em 1987-2017&#44; agrupados em indiv&#237;duos com cardiopatia hipertensiva &#40;HD&#41; e sem cardiopatia &#40;ND&#41; e avaliados de acordo com fatores como idade&#44; sexo &#40;masculino e feminino&#41; e cor &#40;branco e n&#227;o branco&#41;&#46; A quantifica&#231;&#227;o das fibras col&#225;genas foi feita por morfometria computadorizada e a densidade mastocit&#225;ria foi avaliada por m&#233;todos imuno-histoqu&#237;micos&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Houve aumento significativo das fibras col&#225;genas no ventr&#237;culo esquerdo no grupo HD em compara&#231;&#227;o com o grupo ND &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Quanto &#224; densidade mastocit&#225;ria&#44; houve aumento significativo no ventr&#237;culo esquerdo de indiv&#237;duos com HD imunomarcados por antiquimase&#47;antitriptase &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#44;02&#41; e tamb&#233;m na densidade mastocit&#225;ria no ventr&#237;culo esquerdo de indiv&#237;duos imunomarcados por antitriptase &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#44;03&#41;&#46; Analisando o grupo de HD&#44; houve uma correla&#231;&#227;o positiva e significativa entre a porcentagem de fibras col&#225;genas no ventr&#237;culo esquerdo e a densidade mastocit&#225;ria no ventr&#237;culo esquerdo imunomarcados por antiquimase&#47;antitriptase &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#44;04&#41; e tamb&#233;m na densidade mastocit&#225;ria no ventr&#237;culo esquerdo de indiv&#237;duos imunomarcados por antitriptase &#40;p<span class="elsevierStyleMonospace">&#61;</span>0&#44;02&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#245;es</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Os mast&#243;citos est&#227;o envolvidos no desenvolvimento da cardiopatia hipertensiva&#44; contribuem para a remodela&#231;&#227;o das fibras col&#225;genas nessa doen&#231;a&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclus&#245;es"
          ]
        ]
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2427
            "Ancho" => 2167
            "Tamanyo" => 478487
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Histological section of a fragment of left ventricle examined &#40;A&#41; under visible light &#40;arrows&#41; &#40;picrosirius stain&#44; 200<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>&#41; and &#40;B&#41; under polarized light&#44; which reveals birefringent collagen fibers &#40;arrows&#41; &#40;picrosirius stain&#44; 200<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>&#41;&#59; &#40;C and D&#41; mast cells &#40;arrows&#41; immunolabeled with anti-chymase antibodies &#40;immunohistochemistry&#44; 200<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>and 400<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>&#41;&#59; &#40;E and F&#41; mast cells &#40;arrows&#41; immunolabeled with anti-tryptase antibodies &#40;immunohistochemistry&#44; 200<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>and 400<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1071
            "Ancho" => 1411
            "Tamanyo" => 67469
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Correlation between collagen fibers and density of mast cells immunolabeled with anti-chymase and anti-tryptase antibodies&#46; Linear regression fit<span class="elsevierStyleMonospace">&#61;</span>3&#46;03<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>0&#46;26&#46; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;04&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1076
            "Ancho" => 1422
            "Tamanyo" => 68725
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Correlation between collagen fibers and density of mast cells immunolabeled with anti-tryptase antibodies&#46; Linear regression fit<span class="elsevierStyleMonospace">&#61;</span>2&#46;96<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>0&#46;21&#46; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;02&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">HD group &#40;n<span class="elsevierStyleMonospace">&#61;</span>15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">ND group &#40;n<span class="elsevierStyleMonospace">&#61;</span>15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age&#44; years&#44; mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Gender&#44; &#37; &#40;n&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;3 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#46;6 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Race&#44; &#37; &#40;n&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>White&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;3 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#46;3 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Non-white&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#46;6 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;6 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2285360.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">p<span class="elsevierStyleMonospace">&#61;</span>0&#46;262&#44; Student&#39;s t test&#46;</p> <p class="elsevierStyleNotepara" id="npar0010">HD&#58; hypertensive heart disease&#59; ND&#58; no heart disease&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Demographic characteristics of the sample of autopsied patients with hypertensive heart disease and without heart disease&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">&#42; p&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#44; Student&#39;s t test &#40;t&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Collagen fibers &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mast cell density &#40;mast cells&#47;mm<span class="elsevierStyleSup">2</span>&#41;</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Heart weight &#40;g&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Anti-chymase and anti-tryptase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Anti-tryptase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HD &#40;n<span class="elsevierStyleMonospace">&#61;</span>15&#41; &#40;mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;354<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;316<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;145<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;494<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;180<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;453<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">368&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#46;41<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ND &#40;n<span class="elsevierStyleMonospace">&#61;</span>15&#41; &#40;mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;059<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;252<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;754<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;291<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;986<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;259<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">303&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;83<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2285359.png"
              ]
            ]
          ]
          "notaPie" => array:4 [
            0 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">t<span class="elsevierStyleMonospace">&#61;</span>3&#46;199&#44; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;003&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">&#58; t<span class="elsevierStyleMonospace">&#61;</span>2&#46;422&#44; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;02&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0025">&#58;t<span class="elsevierStyleMonospace">&#61;</span>2&#46;287&#44; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;03&#46;</p>"
            ]
            3 => array:3 [
              "identificador" => "tblfn0025"
              "etiqueta" => "d"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0030">&#58; t<span class="elsevierStyleMonospace">&#61;</span>0&#46;016&#44; p<span class="elsevierStyleMonospace">&#61;</span>0&#46;05&#46;</p> <p class="elsevierStyleNotepara" id="npar0035">HD&#58; hypertensive heart disease&#59; ND&#58; no heart disease&#59; t&#58; Student&#39;s t test&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Comparison of percentage of collagen fibers&#44; mast cell density and heart weight in individuals with hypertensive heart disease and without heart disease&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:73 [
            0 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mortality due to cardiovascular diseases in Brazil and in the metropolitan region of S&#227;o Paulo&#58; a 2011 update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;P&#46; Mansur"
                            1 => "D&#46; Favarato"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/s0066-782x2012005000061"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arq Bras Cardiol"
                        "fecha" => "2012"
                        "volumen" => "99"
                        "paginaInicial" => "755"
                        "paginaFinal" => "761"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22735870"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The epidemiologic transition&#58; a theory of epidemiology of population change"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;R&#46; Omram"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Milbank Mem Fund Q"
                        "fecha" => "1971"
                        "volumen" => "49"
                        "paginaInicial" => "509"
                        "paginaFinal" => "538"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5155251"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A sa&#250;de dos idosos brasileiros &#224;s v&#233;speras do s&#233;culo 21&#58; problemas&#44; proje&#231;&#245;es e alternativas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Chaimowicz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/s0034-89101997000200014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Saude Publica"
                        "fecha" => "1997"
                        "volumen" => "31"
                        "paginaInicial" => "184"
                        "paginaFinal" => "200"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9497568"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transi&#231;&#227;o epidemiol&#243;gica e o estudo de carga de doen&#231;a no Brasil"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;M&#46;A&#46; Schramm"
                            1 => "A&#46;F&#46; Oliveira"
                            2 => "I&#46;C&#46; Leite"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cien Saude Colet"
                        "fecha" => "2004"
                        "volumen" => "9"
                        "paginaInicial" => "897"
                        "paginaFinal" => "908"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The development and experience of epidemiological transition theory over four decades&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Santosa"
                            1 => "S&#46; Wall"
                            2 => "E&#46; Fottrell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3402/gha.v7.23574"
                      "Revista" => array:5 [
                        "tituloSerie" => "Glob Health Action"
                        "fecha" => "2014"
                        "volumen" => "7"
                        "paginaInicial" => "23574"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24848657"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ECM remodeling in hypertensive heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;C&#46; Berk"
                            1 => "K&#46; Fujiwara"
                            2 => "S&#46; Lehoux"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "2007"
                        "volumen" => "117"
                        "paginaInicial" => "568"
                        "paginaFinal" => "575"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cellular and molecular mechanisms of fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "T&#46;A&#46; Wynn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/path.2277"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Pathol"
                        "fecha" => "2008"
                        "volumen" => "214"
                        "paginaInicial" => "199"
                        "paginaFinal" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18161745"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S073510971600944X"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathogenesis of cardiac fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Kong"
                            1 => "P&#46; Christia"
                            2 => "N&#46;G&#46; Frangogiannis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00018-013-1349-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell Mol Life Sci"
                        "fecha" => "2014"
                        "volumen" => "71"
                        "paginaInicial" => "549"
                        "paginaFinal" => "574"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23649149"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A role for cardiac mast cells in the pathogenesis of hypertensive heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "N&#46; Shiota"
                            1 => "J&#46; Rysa"
                            2 => "P&#46;T&#46; Kovanen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00004872-200310000-00022"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2003"
                        "volumen" => "21"
                        "paginaInicial" => "1935"
                        "paginaFinal" => "1944"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14508201"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac mast cells&#58; the centrepiece in adverse myocardial remodelling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;P&#46; Levick"
                            1 => "G&#46;C&#46; Melendez"
                            2 => "E&#46; Plante"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/cvr/cvq272"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Res"
                        "fecha" => "2011"
                        "volumen" => "89"
                        "paginaInicial" => "12"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20736239"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term pressure-induced cardiac hypertrophy&#58; capillary and mast cell proliferation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Olivetti"
                            1 => "C&#46; Lagrasta"
                            2 => "R&#46; Ricci"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/ajpheart.1989.257.6.H1766"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol"
                        "fecha" => "1989"
                        "volumen" => "257"
                        "paginaInicial" => "H1766"
                        "paginaFinal" => "H1772"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2532477"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Are mast cells involved in hypertensive heart disease&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Panizo"
                            1 => "F&#46;J&#46; Mindan"
                            2 => "M&#46;F&#46; Galindo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00004872-199510000-00015"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "1995"
                        "volumen" => "13"
                        "paginaInicial" => "1201"
                        "paginaFinal" => "1208"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8586812"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "V&#46; Patella"
                            1 => "I&#46; Marino"
                            2 => "E&#46; Arbustini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.cir.97.10.971"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1998"
                        "volumen" => "97"
                        "paginaInicial" => "971"
                        "paginaFinal" => "978"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9529265"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;J&#46; Leskinen"
                            1 => "K&#46;A&#46; Lindstedt"
                            2 => "Y&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arterioscler Thromb Vasc Biol&#46;"
                        "fecha" => "2003"
                        "volumen" => "23"
                        "paginaInicial" => "238"
                        "paginaFinal" => "243"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Canines as sentinel species for assessing chronic exposures to air pollutants&#58; Part 2"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46; Calder&#243;n-Garciduenas"
                            1 => "A&#46; Mora-Tiscareno"
                            2 => "L&#46;A&#46; Fordham"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/toxsci/61.2.356"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiac pathology&#46; Toxicol Sci"
                        "fecha" => "2001"
                        "volumen" => "61"
                        "paginaInicial" => "356"
                        "paginaFinal" => "367"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11353144"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0445"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endothelin-1 mediates cardiac mast cell degranulation&#44; matrix metalloproteinase activation&#44; and myocardial remodeling in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46;B&#46; Murray"
                            1 => "J&#46;D&#46; Gardner"
                            2 => "G&#46;L&#46; Brower"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/ajpheart.00048.2004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol Heart Circ Physiol&#46;"
                        "fecha" => "2004"
                        "volumen" => "287"
                        "paginaInicial" => "H2295"
                        "paginaFinal" => "H2299"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15231495"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0450"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A novel technique for isolating functional mast cells from the heart"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46;G&#46; Morgan"
                            1 => "S&#46;P&#46; Levick"
                            2 => "T&#46;G&#46; Voloshenyuk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00011-007-6213-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Inflamm Res"
                        "fecha" => "2008"
                        "volumen" => "57"
                        "paginaInicial" => "1"
                        "paginaFinal" => "6"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18209958"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0455"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of mast cell chymase and tryptase in the progression of atherosclerosis&#58; study in 44 autopsied cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46;S&#46; Ramalho"
                            1 => "L&#46;F&#46; Oliveira"
                            2 => "C&#46;L&#46; Cavellani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.anndiagpath.2012.04.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Diagn Pathol"
                        "fecha" => "2013"
                        "volumen" => "17"
                        "paginaInicial" => "28"
                        "paginaFinal" => "31"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22658852"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0460"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adrenomedullin in mast cells of abdominal aortic aneurysm"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46; Tsuruda"
                            1 => "J&#46; Kato"
                            2 => "K&#46; Hatakeyama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cardiores.2006.02.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Res"
                        "fecha" => "2006"
                        "volumen" => "70"
                        "paginaInicial" => "158"
                        "paginaFinal" => "164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16524566"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0465"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mast cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;D&#46; Metcalfe"
                            1 => "D&#46; Baram"
                            2 => "Y&#46;A&#46; Mekori"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/physrev.1997.77.4.1033"
                      "Revista" => array:6 [
                        "tituloSerie" => "Physiol Rev"
                        "fecha" => "1997"
                        "volumen" => "77"
                        "paginaInicial" => "1033"
                        "paginaFinal" => "1079"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9354811"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0470"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased mast cell expression of PAR-2 in skin inflammatory diseases and release of IL-8 upon PAR-2 activation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;F&#46; Carvalho"
                            1 => "G&#46; Nilsson"
                            2 => "I&#46;T&#46; Harvima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0625.2009.00998.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Dermatol"
                        "fecha" => "2010"
                        "volumen" => "19"
                        "paginaInicial" => "117"
                        "paginaFinal" => "122"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19889021"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0475"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human mast cell tryptase stimulates the release of an IL-8-dependent neutrophil chemotactic activity from human umbilical vein endothelial cells &#40;HUVEC&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;J&#46; Compton"
                            1 => "J&#46;A&#46; Cairns"
                            2 => "S&#46;T&#46; Holgate"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Exp Immunol"
                        "fecha" => "2000"
                        "volumen" => "121"
                        "paginaInicial" => "31"
                        "paginaFinal" => "36"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0480"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;P&#46; Levick"
                            1 => "J&#46;L&#46; Mclarty"
                            2 => "D&#46;B&#46; Murray"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/HYPERTENSIONAHA.108.123158"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2009"
                        "volumen" => "53"
                        "paginaInicial" => "1041"
                        "paginaFinal" => "1047"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19398662"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0485"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;F&#46; Reilly"
                            1 => "D&#46;A&#46; Tewksbury"
                            2 => "N&#46;M&#46; Schechter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "1982"
                        "volumen" => "257"
                        "paginaInicial" => "8619"
                        "paginaFinal" => "8622"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6807977"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0490"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Targeting cardiac mast cells&#58; pharmacological modulation of the local renin-angiotensin system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;C&#46; Reid"
                            1 => "J&#46;A&#46; Brazin"
                            2 => "C&#46; Morrey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Curr Pharm"
                        "fecha" => "2011"
                        "volumen" => "17"
                        "paginaInicial" => "3744"
                        "paginaFinal" => "3752"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0495"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Heritability of left ventricular mass&#58; The Framingham Heart Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "W&#46;S&#46; Post"
                            1 => "M&#46;G&#46; Larson"
                            2 => "R&#46;H&#46; Myers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.hyp.30.5.1025"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "1997"
                        "volumen" => "30"
                        "paginaInicial" => "1025"
                        "paginaFinal" => "1028"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9369250"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0500"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacogenetic approaches to hypertension therapy&#58; design and rationale for the Genetics of Hypertension Associated Treatment &#40;GenHAT&#41; study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46;K&#46; Arnett"
                            1 => "E&#46; Boerwinkle"
                            2 => "B&#46;R&#46; Davis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.tpj.6500113"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacogenomics J"
                        "fecha" => "2002"
                        "volumen" => "2"
                        "paginaInicial" => "309"
                        "paginaFinal" => "317"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12439737"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0505"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early markers of cardiovascular disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46;K&#46; Kapuku"
                            1 => "G&#46;A&#46; Harshfield"
                            2 => "H&#46;C&#46; Davis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Vasc Pharmacol"
                        "fecha" => "2006"
                        "volumen" => "45"
                        "paginaInicial" => "277"
                        "paginaFinal" => "280"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0510"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Integrated genomic approaches implicate osteoglycin &#40;Ogn&#41; in the regulation of left ventricular mass"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46;R&#46; Petretto"
                            1 => "R&#46; Sawar"
                            2 => "I&#46; Grieve"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng.134"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2008"
                        "volumen" => "40"
                        "paginaInicial" => "546"
                        "paginaFinal" => "552"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18443592"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0025619617300253"
                          "estado" => "S300"
                          "issn" => "00256196"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0515"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of leukocyte telomere length with echocardiographic left ventricular mass&#58; the Framingham heart study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;S&#46; Vasan"
                            1 => "S&#46; Demissie"
                            2 => "M&#46; Kimura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCULATIONAHA.109.853895"
                      "Revista" => array:7 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2009"
                        "volumen" => "120"
                        "paginaInicial" => "1195"
                        "paginaFinal" => "1202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19752323"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0168822717300669"
                          "estado" => "S300"
                          "issn" => "01688227"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0520"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mast cell tryptases and chymases in inflammation and host defense"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46;H&#46; Caughey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-065X.2007.00509.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Immunol Rev"
                        "fecha" => "2007"
                        "volumen" => "217"
                        "paginaInicial" => "141"
                        "paginaFinal" => "154"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17498057"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0525"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comportamento do peso do cora&#231;&#227;o e do corpo em chag&#225;sicos cr&#244;nicos com e sem &#8220;megas&#8221;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46;O&#46; Almeida"
                            1 => "V&#46;P&#46;A&#46; Teixeira"
                            2 => "W&#46;F&#46; Ara&#250;jo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Soc Bras Med Trop"
                        "fecha" => "1979"
                        "volumen" => "13"
                        "paginaInicial" => "85"
                        "paginaFinal" => "89"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0530"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlations between the collagen content of the human left ventricular myocardium&#44; measured by biochemical and morphometric methods"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;D&#46; Lopes"
                            1 => "R&#46;A&#46; Gomes"
                            2 => "V&#46; Hial"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arq Bras Cardiol"
                        "fecha" => "2002"
                        "volumen" => "79"
                        "paginaInicial" => "15"
                        "paginaFinal" => "19"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0535"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Quantitative methods in biology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;A&#46; Williams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "editores" => "A&#46;M&#46;Glaubert"
                        "titulo" => "Practical methods in electron microscopy&#46;"
                        "paginaInicial" => "233"
                        "serieFecha" => "1977"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0540"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The association of mast cells and atherosclerosis&#58; a morphologic study of early atherosclerotic lesions in young people"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;B&#46; Atkinson"
                            1 => "C&#46;W&#46; Harlan"
                            2 => "G&#46;C&#46; Harlan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Human Pathol"
                        "fecha" => "1994"
                        "volumen" => "25"
                        "paginaInicial" => "154"
                        "paginaFinal" => "159"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0545"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypertensive heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;A&#46; Diamond"
                            1 => "R&#46;A&#46; Phillips"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Hypertens Res"
                        "fecha" => "2005"
                        "volumen" => "28"
                        "paginaInicial" => "191"
                        "paginaFinal" => "202"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0550"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;F&#46; Jim&#233;nez-Navarro"
                            1 => "J&#46;J&#46; G&#243;mez-Doblas"
                            2 => "F&#46; Cabrera-Bueno"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Collagen synthesis and heart failure&#46; Rev Esp Cardiol &#40;Engl Ed&#41;"
                        "fecha" => "2005"
                        "volumen" => "58"
                        "paginaInicial" => "975"
                        "paginaFinal" => "978"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0555"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlation between mast cell density and myocardial fibrosis in congestive heart failure patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Batlle"
                            1 => "F&#46; P&#233;rez-Villa"
                            2 => "A&#46; L&#225;zaro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.transproceed.2007.06.047"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplant Proc"
                        "fecha" => "2007"
                        "volumen" => "39"
                        "paginaInicial" => "2347"
                        "paginaFinal" => "2349"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17889184"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0560"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46;C&#46; Goldsmith"
                            1 => "A&#46;D&#46; Bradshaw"
                            2 => "M&#46;R&#46; Zile"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Myocardial Fibroblast-Matrix Interactions and Potential Therapeutic Targets J Mol Cell Cardiol"
                        "fecha" => "2014"
                        "volumen" => "0"
                        "paginaInicial" => "92"
                        "paginaFinal" => "99"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0565"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Myocardial matrix remodeling and the matrix metalloproteinases&#58; influence on cardiac form and function"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46;G&#46; Spinale"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/physrev.00012.2007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Physiol Rev"
                        "fecha" => "2007"
                        "volumen" => "87"
                        "paginaInicial" => "1285"
                        "paginaFinal" => "1342"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17928585"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0570"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The progression of hypertensive heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;H&#46; Drazner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2011"
                        "volumen" => "123"
                        "paginaInicial" => "327"
                        "paginaFinal" => "334"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0575"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46; Peng"
                            1 => "Z&#46; Sarwar"
                            2 => "X&#46;P&#46; Yang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Profibrotic role for interleukin-4 in cardiac remodeling and dysfunction hypertension"
                        "fecha" => "2015"
                        "volumen" => "66"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0580"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Avalia&#231;&#227;o histol&#243;gica da fibrose card&#237;aca de indiv&#237;duos ur&#234;micos hipertensos&#58; estudo caso e controle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;C&#46; Jorge"
                            1 => "A&#46;J&#46; Mocelin"
                            2 => "T&#46; Matsuo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Bras Nefrol"
                        "fecha" => "2004"
                        "volumen" => "26"
                        "paginaInicial" => "190"
                        "paginaFinal" => "195"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0585"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biochemical assessment of myocardial fibrosis in hypertensive heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46; L&#243;pez"
                            1 => "A&#46; Gonz&#225;lez"
                            2 => "N&#46; Varo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/hy1101.098549"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2001"
                        "volumen" => "38"
                        "paginaInicial" => "1222"
                        "paginaFinal" => "1226"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11711527"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0590"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Procollagen type I carboxy-terminal peptide shows left ventricular hypertrophy and diastolic dysfunction in hypertensive patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Demir"
                            1 => "E&#46; Acarturk"
                            2 => "T&#46; Inal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.carpath.2006.09.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Pathol"
                        "fecha" => "2007"
                        "volumen" => "16"
                        "paginaInicial" => "69"
                        "paginaFinal" => "74"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17317538"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0595"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biochemical markers of myocardial remodelling in hypertensive heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Gonz&#225;lez"
                            1 => "B&#46; L&#243;pez"
                            2 => "S&#46; Ravassa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/cvr/cvn235"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Res"
                        "fecha" => "2009"
                        "volumen" => "81"
                        "paginaInicial" => "509"
                        "paginaFinal" => "518"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18762556"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0600"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Monocyte chemoattractant protein-1 enhances gene expression and synthesis of matrix metalloproteinase-1 in human fibroblasts by an autocrine IL-1 alpha loop"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46; Yamamoto"
                            1 => "B&#46; Eckes"
                            2 => "C&#46; Mauch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "2000"
                        "volumen" => "164"
                        "paginaInicial" => "6174"
                        "paginaFinal" => "6179"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0605"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46;L&#46; Gruber"
                            1 => "M&#46;J&#46; Marchese"
                            2 => "K&#46; Suzuki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI114344"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1989"
                        "volumen" => "84"
                        "paginaInicial" => "1657"
                        "paginaFinal" => "1662"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2553780"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0610"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mast cell proteinases activate precursor forms of collagenase and stromelysin&#44; but not of gelatinases A and B"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Lees"
                            1 => "D&#46;J&#46; Taylor"
                            2 => "D&#46;E&#46; Woolley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Biochem"
                        "fecha" => "1994"
                        "volumen" => "223"
                        "paginaInicial" => "171"
                        "paginaFinal" => "177"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0615"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Activation of precursors for matrix metalloproteinases 1 &#40;interstitial collagenase&#41; and 3 &#40;stromelysin&#41; by rat mast-cell proteinases I and II"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Suzuki"
                            1 => "M&#46; Lees"
                            2 => "G&#46;F&#46; Newlands"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1042/bj3050301"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochem J"
                        "fecha" => "1995"
                        "volumen" => "305"
                        "paginaInicial" => "301"
                        "paginaFinal" => "306"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7826345"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0620"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46; Thougounova"
                            1 => "A&#46; Lundequist"
                            2 => "I&#46; Fajardo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1074/jbc.M410396200"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "2005"
                        "volumen" => "280"
                        "paginaInicial" => "9291"
                        "paginaFinal" => "9296"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15615702"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0625"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46;M&#46; Heikkila"
                            1 => "S&#46; Latti"
                            2 => "M&#46;J&#46; Leskinen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/ATVBAHA.107.151340"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arterioscler Thromb Vasc Biol"
                        "fecha" => "2008"
                        "volumen" => "28"
                        "paginaInicial" => "309"
                        "paginaFinal" => "314"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18079408"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0630"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;P&#46; Hans"
                            1 => "Y&#46; Feng"
                            2 => "A&#46;S&#46; Naura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cardiovasc Pathol"
                        "fecha" => "2011"
                        "volumen" => "20"
                        "paginaInicial" => "e57"
                        "paginaFinal" => "e58"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0635"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46; Matsumoto"
                            1 => "A&#46; Wada"
                            2 => "T&#46; Tsutamoto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR.0000074041.81728.79"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2003"
                        "volumen" => "107"
                        "paginaInicial" => "2555"
                        "paginaFinal" => "2558"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12742989"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0640"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chymase inhibition reduces the progression to heart failure after autoimmune myocarditis in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;S&#46; Palaniyandi"
                            1 => "Y&#46; Nagai"
                            2 => "K&#46; Watanabe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Exp Biol Med"
                        "fecha" => "2007"
                        "volumen" => "232"
                        "paginaInicial" => "1213"
                        "paginaFinal" => "1221"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0645"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Isolation of functional cardiac immune cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;L&#46; McLarty"
                            1 => "G&#46;C&#46; Mel&#233;ndez"
                            2 => "W&#46;J&#46; Spencer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Vis Exp"
                        "fecha" => "2011"
                        "volumen" => "58"
                        "paginaInicial" => "3020"
                        "itemHostRev" => array:3 [
                          "pii" => "S0735109711019528"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0650"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;S&#46; Janicki"
                            1 => "G&#46;L&#46; Brower"
                            2 => "S&#46;P&#46; Levick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/978-1-4939-1568-2_8"
                      "Revista" => array:6 [
                        "tituloSerie" => "The Emerging Prominence of the Cardiac Mast Cell as a Potent Mediator of Adverse Myocardial Remodeling Methods Mol Biol"
                        "fecha" => "2015"
                        "volumen" => "1220"
                        "paginaInicial" => "121"
                        "paginaFinal" => "139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25388248"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0655"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vascular chymase&#58; pathophysiological role and therapeutic potential of inhibition"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;A&#46; Doggrell"
                            1 => "J&#46;C&#46; Wanstall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Casdiovasc Res"
                        "fecha" => "2004"
                        "volumen" => "61"
                        "paginaInicial" => "653"
                        "paginaFinal" => "662"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0660"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Integrated signalling pathways for mast-cell activation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;M&#46; Gilfillan"
                            1 => "C&#46; Tkaczyk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nat Rev"
                        "fecha" => "2006"
                        "volumen" => "6"
                        "paginaInicial" => "218"
                        "paginaFinal" => "230"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0665"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Functional effects of overexpression of protein kinase C-alpha&#44; -beta&#44; -delta -epsilon&#44; and -eta in the mast cell line RBL-2H3"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46;Y&#46; Chang"
                            1 => "Z&#46; Szallasi"
                            2 => "P&#46; Acs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "1997"
                        "volumen" => "159"
                        "paginaInicial" => "2624"
                        "paginaFinal" => "2632"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9300681"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0670"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mast cells and epsilonPKC&#58; a role in cardiac remodeling in hypertension-induced heart failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;S&#46; Palanyiandi"
                            1 => "K&#46; Inagaki"
                            2 => "D&#46; Mochly-Rosen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.yjmcc.2008.08.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Mol Cell Cardiol"
                        "fecha" => "2008"
                        "volumen" => "45"
                        "paginaInicial" => "779"
                        "paginaFinal" => "786"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18804478"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0675"
              "etiqueta" => "62"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Large Accumulation of Collagen and Increased Activation of Mast Cells in Hearts of Mice with Hyperlipidemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "Y&#46; Cheng"
                            1 => "Y&#46; Zhu"
                            2 => "J&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5935/abc.20170143"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arq Bras Cardiol"
                        "fecha" => "2017"
                        "volumen" => "109"
                        "paginaInicial" => "404"
                        "paginaFinal" => "409"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28977053"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib0680"
              "etiqueta" => "63"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prehypertension and black-white contrasts in cardiovascular risk in young adults&#58; Bogalusa Heart Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Toprak"
                            1 => "H&#46; Wang"
                            2 => "W&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/hjh.0b013e32831aeee3"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "paginaInicial" => "243"
                        "paginaFinal" => "250"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19226697"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib0685"
              "etiqueta" => "64"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Family history of hypertension and arterial elasticity characteristics in healthy young people"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46; Zhou"
                            1 => "C&#46; Yuanyuan"
                            2 => "S&#46; Ningling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1291/hypres.31.833"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertens Res"
                        "fecha" => "2008"
                        "volumen" => "31"
                        "paginaInicial" => "833"
                        "paginaFinal" => "839"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18712037"
                             …1
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib0690"
              "etiqueta" => "65"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fatores determinantes e mecanismos moleculares"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arq Bras Cardiol"
                        "fecha" => "1995"
                        "volumen" => "65"
                        "paginaInicial" => "533"
                        "paginaFinal" => "539"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib0695"
              "etiqueta" => "66"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beneficial effects of estrogen treatment in the HLA B27 transgenic rat model of inflammatory bowel disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Physiol Gastrointest Liver Physiol"
                        "fecha" => "2004"
                        "volumen" => "286"
                        "paginaInicial" => "118"
                        "paginaFinal" => "125"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib0700"
              "etiqueta" => "67"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Existe evid&#234;ncia para tratar insufici&#234;ncia card&#237;aca baseada na ra&#231;a ou etnia&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/s0104-42302009000200010"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Assoc Med Bras"
                        "fecha" => "2009"
                        "volumen" => "55"
                        "paginaInicial" => "110"
                        "paginaFinal" => "116"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            67 => array:3 [
              "identificador" => "bib0705"
              "etiqueta" => "68"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ra&#231;a e hipertrofia do ventr&#237;culo esquerdo na aus&#234;ncia de hipertens&#227;o e de doen&#231;as cardiopulmonares"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arq Bras Cardiol"
                        "fecha" => "1994"
                        "volumen" => "62"
                        "paginaInicial" => "413"
                        "paginaFinal" => "416"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            68 => array:3 [
              "identificador" => "bib0710"
              "etiqueta" => "69"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left ventricular hypertrophy in black and white hypertensives Standard electrographic criteria overestimate racial differences in prevalence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1992"
                        "volumen" => "267"
                        "paginaInicial" => "3294"
                        "paginaFinal" => "3299"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0167527316332764"
                          "estado" => "S300"
                          "issn" => "01675273"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            69 => array:3 [
              "identificador" => "bib0715"
              "etiqueta" => "70"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypertensive vascular disease as a cause of death in blacks versus whites&#58; autopsy findings in 587 adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.hyp.31.5.1070"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "1998"
                        "volumen" => "31"
                        "paginaInicial" => "1070"
                        "paginaFinal" => "1076"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            70 => array:3 [
              "identificador" => "bib0720"
              "etiqueta" => "71"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ra&#231;a e les&#227;o de &#243;rg&#227;os-alvo da hipertens&#227;o arterial em pacientes atendidos em um ambulat&#243;rio universit&#225;rio de refer&#234;ncia na cidade de Salvador"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arq Bras Cardiol"
                        "fecha" => "2004"
                        "volumen" => "82"
                        "paginaInicial" => "111"
                        "paginaFinal" => "115"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            71 => array:3 [
              "identificador" => "bib0725"
              "etiqueta" => "72"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Examining racial and ethnic disparities in health and hypertension control"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1370/afm.927"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Fam Med"
                        "fecha" => "2008"
                        "volumen" => "6"
                        "paginaInicial" => "483"
                        "paginaFinal" => "485"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            72 => array:3 [
              "identificador" => "bib0730"
              "etiqueta" => "73"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fibrosis and hypertensive heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Curr Opin Cardiol"
                        "fecha" => "2000"
                        "volumen" => "1513"
                        "paginaInicial" => "264"
                        "paginaFinal" => "272"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/08702551/0000003900000002/v1_202005070648/S0870255120300810/v1_202005070648/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "29261"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Artigos Originais"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08702551/0000003900000002/v1_202005070648/S0870255120300810/v1_202005070648/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255120300810?idApp=UINPBA00004E"
]
Informação do artigo
ISSN: 08702551
Idioma original: Inglês
Dados atualizados diariamente
Ano/Mês Html Pdf Total
2024 Novembro 7 3 10
2024 Outubro 33 36 69
2024 Setembro 41 30 71
2024 Agosto 43 28 71
2024 Julho 36 37 73
2024 Junho 25 16 41
2024 Maio 38 21 59
2024 Abril 34 30 64
2024 Maro 36 19 55
2024 Fevereiro 40 24 64
2024 Janeiro 33 25 58
2023 Dezembro 40 19 59
2023 Novembro 37 29 66
2023 Outubro 22 16 38
2023 Setembro 26 21 47
2023 Agosto 20 18 38
2023 Julho 39 11 50
2023 Junho 43 14 57
2023 Maio 48 28 76
2023 Abril 30 2 32
2023 Maro 51 16 67
2023 Fevereiro 34 14 48
2023 Janeiro 27 16 43
2022 Dezembro 49 19 68
2022 Novembro 70 21 91
2022 Outubro 73 25 98
2022 Setembro 38 43 81
2022 Agosto 46 34 80
2022 Julho 43 31 74
2022 Junho 29 30 59
2022 Maio 25 30 55
2022 Abril 33 38 71
2022 Maro 29 40 69
2022 Fevereiro 29 27 56
2022 Janeiro 20 24 44
2021 Dezembro 19 29 48
2021 Novembro 22 42 64
2021 Outubro 32 43 75
2021 Setembro 29 32 61
2021 Agosto 41 42 83
2021 Julho 31 35 66
2021 Junho 36 25 61
2021 Maio 26 42 68
2021 Abril 26 50 76
2021 Maro 35 27 62
2021 Fevereiro 31 15 46
2021 Janeiro 44 19 63
2020 Dezembro 29 26 55
2020 Novembro 18 24 42
2020 Outubro 40 19 59
2020 Setembro 192 33 225
2020 Agosto 12 17 29
2020 Julho 45 10 55
2020 Junho 40 27 67
2020 Maio 187 49 236
2020 Abril 46 10 56
2020 Maro 17 15 32
Mostrar tudo

Siga este link para acessar o texto completo do artigo

Idiomas
Revista Portuguesa de Cardiologia
en pt

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

Ao assinalar que é «Profissional de Saúde», declara conhecer e aceitar que a responsável pelo tratamento dos dados pessoais dos utilizadores da página de internet da Revista Portuguesa de Cardiologia (RPC), é esta entidade, com sede no Campo Grande, n.º 28, 13.º, 1700-093 Lisboa, com os telefones 217 970 685 e 217 817 630, fax 217 931 095 e com o endereço de correio eletrónico revista@spc.pt. Declaro para todos os fins, que assumo inteira responsabilidade pela veracidade e exatidão da afirmação aqui fornecida.