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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We would like to thank Dario Buccheri for the interest shown in our article &#8220;Spontaneous coronary artery dissection&#58; a single-center case series and literature review&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We reported an interesting case series of spontaneous coronary artery dissection &#40;SCAD&#41; from our center&#44; in which we presented the prevalence of SCAD in our cohort&#44; its form of presentation&#44; patient characteristics&#44; how we managed the condition and its prognosis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">As the author pointed out&#44; SCAD remains an underdiagnosed entity&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">2</span></a> Therefore&#44; it is crucial to have a high level of clinical suspicion&#44; recognize some particular features characteristic of this entity&#44; be familiar with all angiographic patterns and systematically use intracoronary imaging&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We analyzed with great interest the scoring system proposed and tested by Buccheri et al&#46;&#44;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">3&#44;4</span></a> which scores clinical and angiographic variables that raise the suspicion of SCAD and favors the use of optical coherence tomography or intravascular ultrasound to confirm the diagnosis&#46; We think that it could be a useful and practical tool for diagnosis&#44; although it still needs statistical validation in a larger cohort&#46; Although invasive treatment is suggested in the score and in the letter&#44; this kind of strategy is based on case reports and experience in short case series&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">5&#44;6</span></a> Percutaneous treatment of SCAD may carry non-negligible risks&#44; such as secondary iatrogenic dissection&#44; guidewire passage into the false lumen&#44; proximal or distal false lumen propagation during stent deployment&#44; persistent distal dissection&#44; major side branch occlusion or flow limitation&#44; and subacute or late stent malapposition due to intramural hematoma reabsorption&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">7&#44;8</span></a> Indeed&#44; technical failure of percutaneous coronary intervention may occur in up to half of patients with SCAD&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">9</span></a> Dr&#46; Buccheri proposed that in this setting&#44; bioresorbable vascular scaffolds &#40;BVS&#41; might be an interesting therapeutic tool because they allow for SCAD sealing and healing&#44; theoretically with subsequent restoration of the morphological and functional characteristics of the coronary segment treated&#46; This option could be of great importance in cases of long SCAD requiring multiple overlapping permanent stents&#44; which are associated with a high rate of adverse events at follow-up&#46; However&#44; compared with newer drug-eluting stents&#44; BVS are associated with higher risk of device thrombosis and target lesion failure&#44;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">10</span></a> and thus they would probably require longer clinical follow-up and intracoronary imaging control to assess vascular repair and device failure&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In fact&#44; the optimal treatment strategy remains controversial and undetermined&#44; as no randomized trials comparing conservative with revascularization strategies have been carried out&#46; Nevertheless&#44; there is good evidence that the majority of SCAD will first stabilize and then heal completely over time&#44; if managed conservatively&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">9&#44;11&#8211;13</span></a> It is recognized that revascularization in SCAD is challenging&#44; because of the presence of an underlying disrupted and friable vessel wall&#44; not infrequently leading to a suboptimal outcome&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">9&#44;12&#44;14</span></a> In stable patients&#44; i&#46;e&#46; those in whom revascularization is not required&#44; a conservative strategy is generally accepted&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">15&#44;16</span></a> Given the current concern about this condition&#44; the European Society of Cardiology has created a SCAD registry&#44; which we expect will help us to improve our knowledge about this subject&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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Letter to the Editor
Reply to Letter to the Editor “Focus on spontaneous coronary artery dissection: Where are we now?”
Resposta à Carta ao Editor «Foco na disseção espontânea da artéria coronária: Onde estamos agora?»
Glória Abreu
Serviço de Cardiologia, Hospital de Braga, Braga, Portugal
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        "titulo" => "Resposta &#224; Carta ao Editor &#171;Foco na disse&#231;&#227;o espont&#226;nea da art&#233;ria coron&#225;ria&#58; Onde estamos agora&#63;&#187;"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We would like to thank Dario Buccheri for the interest shown in our article &#8220;Spontaneous coronary artery dissection&#58; a single-center case series and literature review&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We reported an interesting case series of spontaneous coronary artery dissection &#40;SCAD&#41; from our center&#44; in which we presented the prevalence of SCAD in our cohort&#44; its form of presentation&#44; patient characteristics&#44; how we managed the condition and its prognosis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">As the author pointed out&#44; SCAD remains an underdiagnosed entity&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">2</span></a> Therefore&#44; it is crucial to have a high level of clinical suspicion&#44; recognize some particular features characteristic of this entity&#44; be familiar with all angiographic patterns and systematically use intracoronary imaging&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We analyzed with great interest the scoring system proposed and tested by Buccheri et al&#46;&#44;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">3&#44;4</span></a> which scores clinical and angiographic variables that raise the suspicion of SCAD and favors the use of optical coherence tomography or intravascular ultrasound to confirm the diagnosis&#46; We think that it could be a useful and practical tool for diagnosis&#44; although it still needs statistical validation in a larger cohort&#46; Although invasive treatment is suggested in the score and in the letter&#44; this kind of strategy is based on case reports and experience in short case series&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">5&#44;6</span></a> Percutaneous treatment of SCAD may carry non-negligible risks&#44; such as secondary iatrogenic dissection&#44; guidewire passage into the false lumen&#44; proximal or distal false lumen propagation during stent deployment&#44; persistent distal dissection&#44; major side branch occlusion or flow limitation&#44; and subacute or late stent malapposition due to intramural hematoma reabsorption&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">7&#44;8</span></a> Indeed&#44; technical failure of percutaneous coronary intervention may occur in up to half of patients with SCAD&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">9</span></a> Dr&#46; Buccheri proposed that in this setting&#44; bioresorbable vascular scaffolds &#40;BVS&#41; might be an interesting therapeutic tool because they allow for SCAD sealing and healing&#44; theoretically with subsequent restoration of the morphological and functional characteristics of the coronary segment treated&#46; This option could be of great importance in cases of long SCAD requiring multiple overlapping permanent stents&#44; which are associated with a high rate of adverse events at follow-up&#46; However&#44; compared with newer drug-eluting stents&#44; BVS are associated with higher risk of device thrombosis and target lesion failure&#44;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">10</span></a> and thus they would probably require longer clinical follow-up and intracoronary imaging control to assess vascular repair and device failure&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In fact&#44; the optimal treatment strategy remains controversial and undetermined&#44; as no randomized trials comparing conservative with revascularization strategies have been carried out&#46; Nevertheless&#44; there is good evidence that the majority of SCAD will first stabilize and then heal completely over time&#44; if managed conservatively&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">9&#44;11&#8211;13</span></a> It is recognized that revascularization in SCAD is challenging&#44; because of the presence of an underlying disrupted and friable vessel wall&#44; not infrequently leading to a suboptimal outcome&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">9&#44;12&#44;14</span></a> In stable patients&#44; i&#46;e&#46; those in whom revascularization is not required&#44; a conservative strategy is generally accepted&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">15&#44;16</span></a> Given the current concern about this condition&#44; the European Society of Cardiology has created a SCAD registry&#44; which we expect will help us to improve our knowledge about this subject&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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Informação do artigo
ISSN: 08702551
Idioma original: Inglês
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