que se leu este artigo
array:25 [ "pii" => "S0870255118305389" "issn" => "08702551" "doi" => "10.1016/j.repc.2018.08.001" "estado" => "S300" "fechaPublicacion" => "2018-09-01" "aid" => "1289" "copyright" => "Sociedade Portuguesa de Cardiologia" "copyrightAnyo" => "2018" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "dis" "cita" => "Rev Port Cardiol. 2018;37:737-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 895 "formatos" => array:3 [ "EPUB" => 96 "HTML" => 485 "PDF" => 314 ] ] "itemSiguiente" => array:20 [ "pii" => "S0870255117304390" "issn" => "08702551" "doi" => "10.1016/j.repc.2017.12.004" "estado" => "S300" "fechaPublicacion" => "2018-09-01" "aid" => "1285" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2018;37:739-45" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1389 "formatos" => array:3 [ "EPUB" => 112 "HTML" => 854 "PDF" => 423 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Longitudinal strain by two-dimensional speckle tracking to assess ventricular function in adults with transposition of the great arteries: Can serial assessment be simplified?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "739" "paginaFinal" => "745" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "<span class="elsevierStyleItalic">Strain</span> longitudinal por <span class="elsevierStyleItalic">speckle tracking</span> para avaliar função ventricular em adultos com transposição das grandes artérias: podemos simplificar a avaliação seriada?" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1000 "Ancho" => 1578 "Tamanyo" => 89299 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Flowchart of patient inclusion. ccTGA: congenitally corrected transposition of the great arteries; d-TGA: dextro-transposition of the great arteries.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ana T. Timóteo, Luísa M. Branco, Sílvia A. Rosa, Ana Galrinho, Lídia Sousa, José A. Oliveira, Maria F. Pinto, Ana F. Agapito, Rui C. Ferreira" "autores" => array:9 [ 0 => array:2 [ "nombre" => "Ana T." "apellidos" => "Timóteo" ] 1 => array:2 [ "nombre" => "Luísa M." "apellidos" => "Branco" ] 2 => array:2 [ "nombre" => "Sílvia A." "apellidos" => "Rosa" ] 3 => array:2 [ "nombre" => "Ana" "apellidos" => "Galrinho" ] 4 => array:2 [ "nombre" => "Lídia" "apellidos" => "Sousa" ] 5 => array:2 [ "nombre" => "José A." "apellidos" => "Oliveira" ] 6 => array:2 [ "nombre" => "Maria F." "apellidos" => "Pinto" ] 7 => array:2 [ "nombre" => "Ana F." "apellidos" => "Agapito" ] 8 => array:2 [ "nombre" => "Rui C." "apellidos" => "Ferreira" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2174204918303477" "doi" => "10.1016/j.repce.2018.09.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204918303477?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255117304390?idApp=UINPBA00004E" "url" => "/08702551/0000003700000009/v2_201810120613/S0870255117304390/v2_201810120613/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S0870255117303852" "issn" => "08702551" "doi" => "10.1016/j.repc.2018.03.015" "estado" => "S300" "fechaPublicacion" => "2018-09-01" "aid" => "1287" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2018;37:727-35" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1704 "formatos" => array:3 [ "EPUB" => 111 "HTML" => 537 "PDF" => 1056 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Myocardial infarction before and after the age of 45: Possible role of platelet receptor polymorphisms" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "727" "paginaFinal" => "735" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Enfarte agudo do miocárdio antes e depois dos 45 anos: possível relação com polimorfismos dos recetores plaquetários" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luís B. Pina-Cabral, Virgínia Carvalhais, Bárbara Mesquita, Cláudia Escórcio, Paulo F. Silva, Paula Pinto, Patrícia Napoleão, Teresa Pinheiro, Maria C. Monteiro, António Almeida-Dias, Begoña Criado" "autores" => array:11 [ 0 => array:2 [ "nombre" => "Luís B." "apellidos" => "Pina-Cabral" ] 1 => array:2 [ "nombre" => "Virgínia" "apellidos" => "Carvalhais" ] 2 => array:2 [ "nombre" => "Bárbara" "apellidos" => "Mesquita" ] 3 => array:2 [ "nombre" => "Cláudia" "apellidos" => "Escórcio" ] 4 => array:2 [ "nombre" => "Paulo F." "apellidos" => "Silva" ] 5 => array:2 [ "nombre" => "Paula" "apellidos" => "Pinto" ] 6 => array:2 [ "nombre" => "Patrícia" "apellidos" => "Napoleão" ] 7 => array:2 [ "nombre" => "Teresa" "apellidos" => "Pinheiro" ] 8 => array:2 [ "nombre" => "Maria C." "apellidos" => "Monteiro" ] 9 => array:2 [ "nombre" => "António" "apellidos" => "Almeida-Dias" ] 10 => array:2 [ "nombre" => "Begoña" "apellidos" => "Criado" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2174204918303179" "doi" => "10.1016/j.repce.2018.09.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204918303179?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255117303852?idApp=UINPBA00004E" "url" => "/08702551/0000003700000009/v2_201810120613/S0870255117303852/v2_201810120613/en/main.assets" ] "asociados" => array:1 [ 0 => array:20 [ "pii" => "S0870255117303852" "issn" => "08702551" "doi" => "10.1016/j.repc.2018.03.015" "estado" => "S300" "fechaPublicacion" => "2018-09-01" "aid" => "1287" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2018;37:727-35" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1704 "formatos" => array:3 [ "EPUB" => 111 "HTML" => 537 "PDF" => 1056 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Myocardial infarction before and after the age of 45: Possible role of platelet receptor polymorphisms" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "727" "paginaFinal" => "735" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Enfarte agudo do miocárdio antes e depois dos 45 anos: possível relação com polimorfismos dos recetores plaquetários" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luís B. Pina-Cabral, Virgínia Carvalhais, Bárbara Mesquita, Cláudia Escórcio, Paulo F. Silva, Paula Pinto, Patrícia Napoleão, Teresa Pinheiro, Maria C. Monteiro, António Almeida-Dias, Begoña Criado" "autores" => array:11 [ 0 => array:2 [ "nombre" => "Luís B." "apellidos" => "Pina-Cabral" ] 1 => array:2 [ "nombre" => "Virgínia" "apellidos" => "Carvalhais" ] 2 => array:2 [ "nombre" => "Bárbara" "apellidos" => "Mesquita" ] 3 => array:2 [ "nombre" => "Cláudia" "apellidos" => "Escórcio" ] 4 => array:2 [ "nombre" => "Paulo F." "apellidos" => "Silva" ] 5 => array:2 [ "nombre" => "Paula" "apellidos" => "Pinto" ] 6 => array:2 [ "nombre" => "Patrícia" "apellidos" => "Napoleão" ] 7 => array:2 [ "nombre" => "Teresa" "apellidos" => "Pinheiro" ] 8 => array:2 [ "nombre" => "Maria C." "apellidos" => "Monteiro" ] 9 => array:2 [ "nombre" => "António" "apellidos" => "Almeida-Dias" ] 10 => array:2 [ "nombre" => "Begoña" "apellidos" => "Criado" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2174204918303179" "doi" => "10.1016/j.repce.2018.09.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204918303179?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255117303852?idApp=UINPBA00004E" "url" => "/08702551/0000003700000009/v2_201810120613/S0870255117303852/v2_201810120613/en/main.assets" ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>" "titulo" => "Genetics and myocardial infarction" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "737" "paginaFinal" => "738" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Joana Barbosa Melo" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Joana Barbosa" "apellidos" => "Melo" "email" => array:1 [ 0 => "mmelo@fmed.uc.pt" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Laboratório de Citogenética e Genómica, CNC.IBILI, CIMAGO, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Genética e enfarte do miocárdio" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Genetic information is being increasingly used as part of individual clinical care, and genomic medicine is having an impact in several medical fields, especially in rare and undiagnosed diseases but also in oncology, pharmacology, and cardiology, among others. The ability to use genomic information to improve health is a direct result of the Human Genome Project (HGP), but translation of new discoveries into use in patient care can take years. Since completion of the HGP the focus has been on understanding how variations in an individual's DNA may affect disease and health, clarifying disease etiologies and prognosis, identifying variants that confer disease susceptibility, and improving the efficacy and safety of pharmacological treatments.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Discoveries in cardiovascular genetics are increasingly moving from bench to bedside and becoming more and more relevant to the clinical management of patients.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> This field encompasses a wide variety of inherited cardiac conditions, including monogenic diseases such as various channelopathies and cardiomyopathies, and, although still at a very early stage, some disorders with a more complex inheritance pattern.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Myocardial infarction (MI) is a complex multifactorial disorder caused by the interaction of environmental and genetic factors. It is the most severe type of coronary artery disease (CAD) and one of the leading causes of death worldwide. Several risk factors for MI have been identified, particularly hypertension, dyslipidemia, diabetes and smoking.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Various studies have also addressed the importance of genetic factors, but despite the progress in cardiovascular genetics, data on the genetic background of MI are still limited and somewhat inconsistent.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Clinical and population-based studies have long shown that a positive family history for MI is a major cardiovascular risk factor. However, the heterogeneity of CAD and its clinical complications introduce significant complexity in genetic studies,<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> and the range of genes underlying the heritable component of MI is not fully known. The Coronary ARtery DIsease Genome wide Replication and Meta-analysis plus The Coronary Artery Disease (CARDIoGRAMplusC4D) consortium is an example of a collaborative effort to combine data from multiple large-scale genetic studies to identify risk loci for CAD and MI.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Current knowledge of genetic variants affecting risk of CAD is largely based on analysis of common single-nucleotide polymorphisms (SNPs) in genome-wide association studies.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Several genetic loci have been associated with CAD and it appears that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> In the context of CAD and MI, as for other disorders with complex inheritance patterns, it is also important to consider epigenetic mechanisms that regulate the expression of these genes, and interactions between multiple genes and between these genes and environmental factors, as well as isolated genetic risk factors.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Knowledge of the genetic factors associated with the risk of MI is of particular importance for clinical management. Coronary atherosclerosis underlies the occurrence of MI in the majority of cases, and factors such as plaque vulnerability and the extent of thrombotic reaction to plaque disruption may predispose to MI in the presence of CAD.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> It is accepted that the rupture of a vulnerable atherosclerotic plaque, local activation of thrombotic mechanisms with or without severe underlying stenosis, local thrombosis formation and arterial lumen closure are the mechanisms most often underlying acute MI.</p><p id="par0025" class="elsevierStylePara elsevierViewall">In the current issue of the <span class="elsevierStyleItalic">Journal</span>, Pina-Cabral et al.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> analyze the potential role of eight polymorphisms in four genes coding for platelet receptors, <span class="elsevierStyleItalic">GP1BA</span>, <span class="elsevierStyleItalic">ITGB3</span>, <span class="elsevierStyleItalic">ITGA2</span> and <span class="elsevierStyleItalic">P2RY12</span>, as risk factors for MI. It is known that platelet G protein-coupled receptors are critical regulators of platelet function, and it has been hypothesized that increased platelet activity at the site of atherosclerotic plaque rupture may result in MI.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Pina-Cabral et al.’s study has several limitations that are clearly stated by the authors, including the low numbers of patients and polymorphisms studied and heterogeneity between the control and MI groups, which limit the conclusions of the study. Despite its limitations, the paper assesses these polymorphisms in a Portuguese population and underlines the importance of fully understanding the genetic factors and molecular mechanisms behind the pathogenesis of MI, highlighting the need for further studies addressing genetic risk factors for MI.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Previously, genetic testing was based on conventional techniques like Sanger sequencing, analyzing genes one by one, but recent advances in DNA sequencing technologies have made it possible to investigate large numbers of disease genes simultaneously.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> These new sequencing methods, known as next-generation sequencing (NGS), are able to maximize the number of bases sequenced in the least amount of time, generating a wealth of data that can be used to understand complex phenotypes. These techniques are providing researchers and clinicians with a variety of tools to probe genomes in greater depth, leading to an enhanced understanding of how genome sequence variants underlie phenotype and disease.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> Not surprisingly, clinical screening tools for whole-exome or genome sequencing are now entering the clinical domain, and the results they generate are beginning to be used by different medical specialties, including cardiology. With this in mind, as a final remark, it is important to emphasize that as genetic testing advances and NGS technologies become more accessible and affordable, training in cardiovascular genetics will be critical to ensure that the cardiological community is able to provide effective high-quality care for patients and families.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Implementing genome-driven personalized cardiology in clinical practice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Pasipoularides" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.yjmcc.2018.01.008" "Revista" => array:6 [ "tituloSerie" => "J Mol Cell Cardiol" "fecha" => "2018" "volumen" => "115" "paginaInicial" => "142" "paginaFinal" => "157" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29343412" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Training in cardiovascular genetics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V. Beauséjour Ladouceur" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2015.01.003" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2015" "volumen" => "65" "paginaInicial" => "856" "paginaFinal" => "858" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25720629" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors for myocardial infarction in women and men: insights from the INTERHEART study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.S. Anand" 1 => "S. Islam" 2 => "A. Rosengren" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehn018" "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2008" "volumen" => "29" "paginaInicial" => "932" "paginaFinal" => "940" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18334475" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Variants of the coagulation and inflammation genes are replicably associated with myocardial infarction and epistatically interact in Russians" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R.M. Barsova" 1 => "D. Lvovs" 2 => "B.V. Titov" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0144190" "Revista" => array:5 [ "tituloSerie" => "PLoS ONE" "fecha" => "2015" "volumen" => "10" "paginaInicial" => "e0144190" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26658659" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetics of coronary artery disease and myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "X. Dai" 1 => "S. Wiernek" 2 => "J.P. Evans" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4330/wjc.v8.i1.1" "Revista" => array:6 [ "tituloSerie" => "World J Cardiol" "fecha" => "2016" "volumen" => "8" "paginaInicial" => "1" "paginaFinal" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26839654" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Nikpay" 1 => "A. Goel" 2 => "H.H. Won" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng.3396" "Revista" => array:6 [ "tituloSerie" => "Nat Genet" "fecha" => "2015" "volumen" => "47" "paginaInicial" => "1121" "paginaFinal" => "1130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26343387" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Myocardial infarction before and after the age of 45: possible role of platelet receptor polymorphisms" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L.B. Pina-Cabral" 1 => "V. Carvalhais" 2 => "B. Mesquita" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.repc.2018.03.015" "Revista" => array:6 [ "tituloSerie" => "Rev Port Cardiol" "fecha" => "2018" "volumen" => "37" "paginaInicial" => "727" "paginaFinal" => "735" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30143348" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathophysiological consequences of receptor mistraffic: tales from the platelet P2Y12 receptor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.R. Cunningham" 1 => "R. Aungraheeta" 2 => "S.J. Mundell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.mce.2017.02.016" "Revista" => array:6 [ "tituloSerie" => "Mol Cell Endocrinol" "fecha" => "2017" "volumen" => "449" "paginaInicial" => "74" "paginaFinal" => "81" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28212842" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "The current role of next-generation DNA sequencing in routine care of patients with hereditary cardiovascular conditions: a viewpoint paper of the European Society of Cardiology working group on myocardial and pericardial diseases and members of the European Society of Human Genetics" "etal" => true "autores" => array:3 [ 0 => "J. Mogensen" 1 => "J.P. van Tintelen" 2 => "S. Fokstuen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehv122" "Revista" => array:7 [ "tituloSerie" => "Eur Heart J" "fecha" => "2015" "volumen" => "36" "paginaInicial" => "1367" "paginaFinal" => "1370" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25845928" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0002939411006957" "estado" => "S300" "issn" => "00029394" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Coming of age: ten years of next-generation sequencing technologies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Goodwin" 1 => "J.D. McPherson" 2 => "W.R. McCombie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrg.2016.49" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Genet" "fecha" => "2016" "volumen" => "17" "paginaInicial" => "333" "paginaFinal" => "351" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27184599" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/08702551/0000003700000009/v2_201810120613/S0870255118305389/v2_201810120613/en/main.assets" "Apartado" => array:4 [ "identificador" => "29261" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Artigos Originais" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/08702551/0000003700000009/v2_201810120613/S0870255118305389/v2_201810120613/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255118305389?idApp=UINPBA00004E" ]
Ano/Mês | Html | Total | |
---|---|---|---|
2024 Novembro | 6 | 6 | 12 |
2024 Outubro | 26 | 33 | 59 |
2024 Setembro | 37 | 27 | 64 |
2024 Agosto | 27 | 24 | 51 |
2024 Julho | 34 | 29 | 63 |
2024 Junho | 36 | 26 | 62 |
2024 Maio | 33 | 21 | 54 |
2024 Abril | 26 | 24 | 50 |
2024 Maro | 35 | 14 | 49 |
2024 Fevereiro | 28 | 21 | 49 |
2024 Janeiro | 16 | 24 | 40 |
2023 Dezembro | 13 | 19 | 32 |
2023 Novembro | 27 | 26 | 53 |
2023 Outubro | 15 | 14 | 29 |
2023 Setembro | 20 | 17 | 37 |
2023 Agosto | 18 | 18 | 36 |
2023 Julho | 28 | 12 | 40 |
2023 Junho | 31 | 12 | 43 |
2023 Maio | 34 | 22 | 56 |
2023 Abril | 19 | 6 | 25 |
2023 Maro | 35 | 18 | 53 |
2023 Fevereiro | 22 | 19 | 41 |
2023 Janeiro | 14 | 8 | 22 |
2022 Dezembro | 22 | 22 | 44 |
2022 Novembro | 35 | 22 | 57 |
2022 Outubro | 21 | 16 | 37 |
2022 Setembro | 33 | 25 | 58 |
2022 Agosto | 22 | 41 | 63 |
2022 Julho | 25 | 28 | 53 |
2022 Junho | 21 | 19 | 40 |
2022 Maio | 20 | 33 | 53 |
2022 Abril | 25 | 23 | 48 |
2022 Maro | 18 | 30 | 48 |
2022 Fevereiro | 15 | 28 | 43 |
2022 Janeiro | 23 | 23 | 46 |
2021 Dezembro | 17 | 23 | 40 |
2021 Novembro | 22 | 27 | 49 |
2021 Outubro | 27 | 44 | 71 |
2021 Setembro | 24 | 28 | 52 |
2021 Agosto | 21 | 40 | 61 |
2021 Julho | 24 | 30 | 54 |
2021 Junho | 17 | 30 | 47 |
2021 Maio | 23 | 39 | 62 |
2021 Abril | 28 | 39 | 67 |
2021 Maro | 46 | 22 | 68 |
2021 Fevereiro | 43 | 16 | 59 |
2021 Janeiro | 34 | 17 | 51 |
2020 Dezembro | 37 | 13 | 50 |
2020 Novembro | 17 | 17 | 34 |
2020 Outubro | 37 | 30 | 67 |
2020 Setembro | 33 | 18 | 51 |
2020 Agosto | 9 | 9 | 18 |
2020 Julho | 48 | 8 | 56 |
2020 Junho | 21 | 12 | 33 |
2020 Maio | 26 | 5 | 31 |
2020 Abril | 46 | 20 | 66 |
2020 Maro | 14 | 7 | 21 |
2020 Fevereiro | 23 | 35 | 58 |
2020 Janeiro | 20 | 5 | 25 |
2019 Dezembro | 23 | 9 | 32 |
2019 Novembro | 24 | 9 | 33 |
2019 Outubro | 39 | 6 | 45 |
2019 Setembro | 45 | 15 | 60 |
2019 Agosto | 10 | 7 | 17 |
2019 Julho | 16 | 11 | 27 |
2019 Junho | 24 | 20 | 44 |
2019 Maio | 21 | 12 | 33 |
2019 Abril | 17 | 24 | 41 |
2019 Maro | 23 | 14 | 37 |
2019 Fevereiro | 6 | 12 | 18 |
2019 Janeiro | 15 | 15 | 30 |
2018 Dezembro | 15 | 29 | 44 |
2018 Novembro | 31 | 12 | 43 |
2018 Outubro | 131 | 66 | 197 |
2018 Setembro | 10 | 15 | 25 |