Editorial comment
Obesity and hypertension in children: A worldwide problem
Obesidade e hipertensão arterial nas crianças: um problema à escala mundial
Sofia Ferreira
Departamento de Pediatria, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal
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class="elsevierStyleTextfn">Editorial comment</span>" "titulo" => "Obesity and hypertension in children: A worldwide problem" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "433" "paginaFinal" => "434" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Sofia Ferreira" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Sofia" "apellidos" => "Ferreira" "email" => array:1 [ 0 => "sf.mar@sapo.pt" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Departamento de Pediatria, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Obesidade e hipertensão arterial nas crianças: um problema à escala mundial" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Childhood obesity is an important and concerning public health problem. Its prevalence is increasing worldwide, as are obesity-related diseases, at ever younger ages, in both developed and developing countries.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1–3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">According to the World Health Organization, worldwide obesity rates have nearly tripled since 1975. In 2016, more than 39% of adults aged 18 years and over were overweight and 13% were obese. The prevalence of overweight and obesity among children and adolescents aged 5 to 19 rose dramatically from 4% in 1975 to over 18% in 2016.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Portugal presents one of the highest prevalences of pediatric obesity and overweight in Europe.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Overweight and obesity are linked to higher mortality worldwide than underweight.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Obesity-related diseases, usually considered adult diseases, are more frequently affecting children and adolescents. Obesity-related comorbidities affect the cardiovascular, endocrine, pulmonary and gastrointestinal systems, as well as having psychosocial effects.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,3</span></a> Hypertension, classically an adult problem, used to be a rare condition in children, in whom it was mostly secondary to renal, endocrine or cardiovascular disorders, such as coarctation of the aorta. However, primary hypertension is becoming more prevalent in childhood.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Various studies have shown that weight gain is associated with increased blood pressure (BP) and hypertension and that the prevalence of hypertension is much higher in obese than in non-obese children.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Obesity in children is defined as a body mass index (BMI) at or above the 95th percentile for age and gender.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5,6</span></a> BMI is a strong predictor of BP in children and adolescents, and predicts overweight and obesity in adulthood.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Normal BP in children is defined as systolic and diastolic BP below the 90th percentile for age and height, while hypertension in children is defined as mean systolic and diastolic BP above the 95th percentile for age and height. BP should be measured on at least three separate occasions.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5,6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The prevalence of metabolic syndrome has increased in recent years, along with obesity in the young. It is associated with increased risk of cardiovascular morbidity and mortality.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Hypertension is the first cardiovascular problem to appear in the obese child and is being diagnosed at earlier ages. Understanding of some of the complex physiological mechanisms involved in obesity-related hypertension is important, since it can have therapeutic implications.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Neural activity to the kidney and skeletal muscle is increased in obesity in both hypertensive and normotensive children, but may be influenced by environmental and genetic factors. Activation of the renin-angiotensin system may contribute to hypertension, increasing renal sodium retention and mineralocorticoid activity. Regulation of vascular resistance by the endothelium also has an important role; endothelium-derived nitric oxide induces vascular relaxation and is depressed in obese children. Adipose tissue produces several endocrine substances which have been implicated in BP. Leptin, an amino acid peptide, promotes weight loss by reducing appetite and increasing energy expenditure through activation of the sympathetic nervous system by central mediation on the hypothalamus and local peripheral action, but there appears to be leptin resistance in obesity. Obesity is also associated with resistance to insulin-stimulated glucose uptake and hyperinsulinemia; weight loss increases insulin sensitivity.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Due to the risk of systemic complications, obese children with BP above the 90th percentile for height and gender should be treated. This treatment should begin with diet and exercise, since the fundamental cause of obesity and overweight is an energy imbalance between calories consumed and calories expended.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Behavior modification programs and parental involvement may lead to significant weight loss in obese children. If obesity is sustained it can have an important effect on adult risk for hypertension and coronary heart disease.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,7</span></a> Actions to promote health in the school environment are a useful tool to change patterns of health and disease in the young population. Pharmacological interventions may have little effect in reducing BMI and body weight in obese children and adolescents.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4,8</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">BMI in adolescence is a powerful predictor of adult obesity and risk for hypertension. The waist-hip ratio correlates strongly with resting and ambulatory BP, and is therefore among the tools used to infer which children are at risk for obesity and/or hypertension.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,2,7</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The importance of anthropometric and BP measurements at age three years and older by the child's general practitioner (and before this age, in special cases) is recognized. BMI and waist-hip ratio can help to predict the evolution of the child's growth and weight gain, in order to detect and prevent obesity and its comorbidities.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,3</span></a> Methods that take into account variations in adiposity over time and over the BMI spectrum may be considered superior approaches.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Further research is needed to explore the best methods to summarize the dynamic of adiposity over time.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Parents should be aware that there are important periods in their child's development that can induce a predisposition to obesity, beginning with prenatal development and continuing with non-breast feeding during the first six months of life and inappropriate nutritional diversification during the first years of the child's life and during adolescence.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,3</span></a> There should be an awareness that obesity and the resulting problems are preventable.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">There have been considerable changes in eating patterns in recent years, including reduced frequency of eating breakfast and increased intake of energy-dense food and beverages, as well as increases in physical inactivity due to sedentary forms of playing, working and transportation.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,7</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">There is worldwide concern about this childhood health problem. In order to halt and reverse this trend, many groups have been formed to develop and implement guidelines designed in order to minimize the short- and long-term effects on young people's health. Strategies should be implemented involving parents, schools, the media and the food industry, in order to increase their awareness of the short- and long-term health problems that an obese child may suffer, and to minimize the resulting morbidities.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3,8</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">As stated above, there is a strong association between adiposity, overweight and obesity, and hypertension. The article by Vieira et al. published in this issue of the <span class="elsevierStyleItalic">Journal</span><a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> examines this problem in small children (aged 4-7 years) and emphasizes the importance of assessing anthropometric parameters (BMI and waist-height ratio) and their relationship with BP. Sociodemographic and lifestyle parameters were also assessed, as well as nutritional and exercise habits. The authors found an association between high BMI and waist-height ratio and increased BP. They propose that these parameters should be used for the early identification of overweight or obese children and to prevent the associated comorbidities.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Community-based social intervention programs should be established, in order to change habits and mentalities.</p><p id="par0090" class="elsevierStylePara elsevierViewall">More research and clinical trials are needed to continue to improve the treatment of childhood obesity-related comorbidities and to develop evidence-based guidelines.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5,10</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0095" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity-related hypertension: epidemiology, pathophysiology, and clinical management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. 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| Ano/Mês | Html | Total | |
|---|---|---|---|
| 2024 Novembro | 5 | 3 | 8 |
| 2024 Outubro | 45 | 31 | 76 |
| 2024 Setembro | 45 | 21 | 66 |
| 2024 Agosto | 54 | 27 | 81 |
| 2024 Julho | 45 | 35 | 80 |
| 2024 Junho | 50 | 45 | 95 |
| 2024 Maio | 34 | 20 | 54 |
| 2024 Abril | 38 | 28 | 66 |
| 2024 Maro | 40 | 18 | 58 |
| 2024 Fevereiro | 36 | 21 | 57 |
| 2024 Janeiro | 31 | 21 | 52 |
| 2023 Dezembro | 28 | 21 | 49 |
| 2023 Novembro | 45 | 27 | 72 |
| 2023 Outubro | 19 | 14 | 33 |
| 2023 Setembro | 29 | 20 | 49 |
| 2023 Agosto | 29 | 20 | 49 |
| 2023 Julho | 12 | 9 | 21 |
| 2023 Junho | 37 | 13 | 50 |
| 2023 Maio | 33 | 26 | 59 |
| 2023 Abril | 29 | 7 | 36 |
| 2023 Maro | 27 | 26 | 53 |
| 2023 Fevereiro | 24 | 27 | 51 |
| 2023 Janeiro | 14 | 15 | 29 |
| 2022 Dezembro | 38 | 23 | 61 |
| 2022 Novembro | 37 | 31 | 68 |
| 2022 Outubro | 32 | 23 | 55 |
| 2022 Setembro | 31 | 53 | 84 |
| 2022 Agosto | 29 | 47 | 76 |
| 2022 Julho | 27 | 47 | 74 |
| 2022 Junho | 25 | 29 | 54 |
| 2022 Maio | 25 | 36 | 61 |
| 2022 Abril | 40 | 42 | 82 |
| 2022 Maro | 25 | 50 | 75 |
| 2022 Fevereiro | 25 | 39 | 64 |
| 2022 Janeiro | 26 | 25 | 51 |
| 2021 Dezembro | 21 | 34 | 55 |
| 2021 Novembro | 37 | 30 | 67 |
| 2021 Outubro | 22 | 56 | 78 |
| 2021 Setembro | 20 | 31 | 51 |
| 2021 Agosto | 40 | 37 | 77 |
| 2021 Julho | 18 | 25 | 43 |
| 2021 Junho | 26 | 22 | 48 |
| 2021 Maio | 28 | 28 | 56 |
| 2021 Abril | 49 | 53 | 102 |
| 2021 Maro | 55 | 21 | 76 |
| 2021 Fevereiro | 58 | 12 | 70 |
| 2021 Janeiro | 32 | 21 | 53 |
| 2020 Dezembro | 31 | 20 | 51 |
| 2020 Novembro | 37 | 17 | 54 |
| 2020 Outubro | 20 | 25 | 45 |
| 2020 Setembro | 48 | 17 | 65 |
| 2020 Agosto | 21 | 23 | 44 |
| 2020 Julho | 41 | 10 | 51 |
| 2020 Junho | 35 | 10 | 45 |
| 2020 Maio | 35 | 5 | 40 |
| 2020 Abril | 46 | 25 | 71 |
| 2020 Maro | 28 | 9 | 37 |
| 2020 Fevereiro | 101 | 48 | 149 |
| 2020 Janeiro | 25 | 8 | 33 |
| 2019 Dezembro | 27 | 6 | 33 |
| 2019 Novembro | 91 | 17 | 108 |
| 2019 Outubro | 25 | 7 | 32 |
| 2019 Setembro | 27 | 11 | 38 |
| 2019 Agosto | 25 | 10 | 35 |
| 2019 Julho | 29 | 9 | 38 |
| 2019 Junho | 44 | 17 | 61 |
| 2019 Maio | 35 | 15 | 50 |
| 2019 Abril | 30 | 26 | 56 |
| 2019 Maro | 39 | 13 | 52 |
| 2019 Fevereiro | 27 | 10 | 37 |
| 2019 Janeiro | 32 | 8 | 40 |
| 2018 Dezembro | 17 | 12 | 29 |
| 2018 Novembro | 39 | 11 | 50 |
| 2018 Outubro | 61 | 16 | 77 |
| 2018 Setembro | 35 | 13 | 48 |
| 2018 Agosto | 29 | 12 | 41 |
| 2018 Julho | 37 | 6 | 43 |
| 2018 Junho | 72 | 39 | 111 |
| 2018 Maio | 29 | 32 | 61 |
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