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        "titulo" => "Abordagem da <span class="elsevierStyleItalic">Heart Team</span> &#224; TAVI&#58; o que tem sido feito e o que se espera"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Aortic stenosis is the most common acquired valvular heart disease in Europe&#46; Its importance is growing not only because of its prevalence&#44; but also because percutaneous treatment options have emerged in the last fifteen years that provide validated and effective treatment for previously untreatable patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">1&#44;2</span></a> Although a variety of devices are now available for treating patients of advanced age and with complex disease&#44; not all patients are suitable candidates for transcatheter aortic valve implantation &#40;TAVI&#41;&#44; and patient selection remains a challenge&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The world&#39;s first TAVI procedure was performed by Alan Cribier in 2002&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> The technique was first used in Portugal five years later in August 2007&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">4</span></a> and since then many other centers have developed a TAVI program&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">5</span></a> There are now as many as eleven functioning TAVI centers in Portugal&#44; which annually perform over 56 procedures per million population&#44; a figure that is growing&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Comorbidity&#44; disability&#44; and frailty are three entities that are particularly associated with elderly candidates&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">6</span></a> The STS&#47;ACC TVT Registry reports that TAVI patients are elderly&#44; highly symptomatic and frail&#44; with multiple comorbidities and advanced functional class&#44; a high Society of Thoracic Surgeons-predicted risk of mortality&#44; and poor self-reported health status&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">7</span></a> Considering all these factors&#44; it is not surprising that a significant percentage of patients die or fail to show improved quality of life in follow-up&#46; The need to optimize the decision-making process in these complex patients has led to increased interaction between different specialties&#46; Thus the concept of the heart team was born and has been widely applied ever since&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The value of a dedicated heart team assessment prior to TAVI is best shown by the team&#39;s ability to bring multidisciplinary clinical expertise to bear on two aspects of patient eligibility&#58; risk stratification and analysis of futility&#46; Integrating these two aspects should allow for better performance in assessing how the patient&#39;s quality of life and survival may be influenced by the valve disease and associated conditions&#44; and in determining the treatment option that best balances risk and benefit&#46; The importance of a heart team assessment is acknowledged in current practice guidelines&#44; but is not reflected in a substantial quantity of publications on real-life applications&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In this issue of the <span class="elsevierStyleItalic">Journal</span>&#44; Costa et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">8</span></a> address the advantages of a systematic multidisciplinary approach to TAVI patients and provide insight into the heart team&#39;s assessment of TAVI candidates in a single large-volume national center&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The authors describe three steps for patient assessment&#58; clinical assessment&#44; non-invasive and invasive tests&#44; and finally a multidisciplinary discussion&#46; For the latter&#44; a multidisciplinary team composed of clinical and interventional cardiologists&#44; experts in cardiac imaging&#44; heart failure specialists and cardiac surgeons meet regularly to define treatment strategies&#46; Notably&#44; the article is co-authored by a multidisciplinary team from different medical centers composed of the above-mentioned areas of expertise&#44; as well as a researcher at the Chronic Diseases Research Center &#40;CEDOC&#41; of Nova Medical School&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The sample included 473 patients from 2008 to 2015&#44; in 383 of whom a heart team assessment was completed&#46; A significant number of patients were selected for surgical aortic valve replacement &#40;SAVR&#41; &#40;20&#46;9&#37;&#41; or for medical therapy alone &#40;23&#46;2&#37;&#41; &#40;overall 169 of 383&#44; 44&#46;1&#37;&#41;&#44; reflecting the wide range of patient complexity&#46; Those undergoing SAVR or TAVI were followed at 30 days&#44; six months and one year after the procedure&#44; and then annually&#59; the authors do not mention a systematic follow-up of patients under medical therapy alone&#44; which was presumably performed by the clinical cardiologist&#46; The criteria for TAVI included inoperability or high surgical risk&#44; and a subjective assessment of lack of futility&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">A simple dedicated TAVI risk score remains an unmet clinical need&#46; Most risk scores were designed for surgical risk&#44; and patients under analysis for TAVI are beyond that stage&#46; Integration with variables such as frailty &#40;including muscle strength&#44; gait speed&#44; weight loss&#44; exhaustion&#44; and level of activity&#41;&#44; the patient&#39;s capacity for self-care&#44; and home oxygen use appear to contribute to more precise stratification&#46; The TAVI<span class="elsevierStyleInf">2</span>-SCORe by Debonnaire et al&#46; stratifies patients into five risk groups for one-year mortality based on a retrospective analysis of 511 individuals who underwent TAVI&#44; with better results than the logistic EuroSCORE&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">9</span></a> Hermiller et al&#46; published a novel score for early and late mortality in extreme-risk and high-risk patients that accurately stratified patients into low&#44; moderate and high risk&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">10</span></a> while Capodanno et al&#46; proposed a simple seven-factor risk tool &#40;the OBSERVANT score&#41; for prediction of 30-day mortality after TAVI&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">11</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In parallel with risk stratification is the development of new tools for predicting clinical futility&#44; and this entails looking at the patient from a different angle&#46; Futility can be defined by the combination of death and&#47;or absence of improvement in functional class during short-term follow-up post-procedure &#40;six months to one year&#41;&#46; Other definitions are possible and this is still a hotly debated topic&#46; Factors influencing futility of treatment include non-cardiovascular conditions such as chronic lung disease &#40;CLD&#41;&#44; advanced chronic kidney disease and frailty&#44; and various cardiovascular conditions&#44; including reduced left ventricular ejection fraction&#44; pulmonary hypertension&#44; low trans-aortic gradient&#44; low-flow state or severe organic mitral regurgitation&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">12</span></a> An analysis of futility has been performed for a Portuguese TAVI population of 340 patients with a mean STS score of 5&#46;67&#177;4&#46;17&#37;&#46; The authors found that age&#44; CLD&#44; New York Heart Association functional class &#8805;III prior to the procedure and a non-transfemoral approach were predictors of futility for this population&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">13</span></a> Apart from its clinical impact&#44; analysis of futility is also closely related to the healthcare costs of TAVI&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Although the TAVI and SAVR groups appear to have performed well in the population analyzed by Costa et al&#46;&#44; there is still room for improvement&#44; as the authors recognize&#46; The fact that many patients died &#40;12&#37; of the study population&#41; while awaiting heart team assessment or TAVI itself is a reminder of the severity of these patients and that appropriate strategies need to provide a more timely response from the healthcare system&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Heart team assessment should not only help clarify which patients are unlikely to benefit from TAVI&#44; but should also translate into a positive effect on healthcare costs&#46; Perhaps one of the most important statements by Costa et al&#46; is that results are continuously monitored and all clinical and procedural data are collected in a dedicated database &#40;Cardiobase&#41; and included in an ongoing registry&#44; the Valve Catheter Restorative Operation on Santa Cruz Hospital &#40;VCROSS&#41;&#46; It is reassuring to know that monitoring of results is taking place&#46; This is critical for self-evaluation and improvement in any system and should be highlighted as a reference for currently implemented systems at other intervention centers&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">To conclude&#44; the accurate measurement of procedural outcomes for TAVI patients should include procedure-related clinical events&#44; and also an assessment of quality of life and functional capacity&#46; In the population analyzed by Costa et al&#46;&#44; an analysis of quality of life and characterization of patients for whom the procedure was deemed futile could expand the analysis of the quality of treatment&#46; Performing this analysis for the population of the national TAVI registry and determining predictors of futility could result in a valuable tool for heart teams in the future&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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Editorial comment
The heart team approach to transcatheter aortic valve implantation: What has been done and what is to be expected
Abordagem da Heart Team à TAVI: o que tem sido feito e o que se espera
Gustavo Pires-Morais
Autor para correspondência
gpmorais@gmail.com

Corresponding author.
, Vasco Gama
Cardiovascular Intervention Unit, Department of Cardiology, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal
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    "titulo" => "The heart team approach to transcatheter aortic valve implantation&#58; What has been done and what is to be expected"
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        "titulo" => "Abordagem da <span class="elsevierStyleItalic">Heart Team</span> &#224; TAVI&#58; o que tem sido feito e o que se espera"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Aortic stenosis is the most common acquired valvular heart disease in Europe&#46; Its importance is growing not only because of its prevalence&#44; but also because percutaneous treatment options have emerged in the last fifteen years that provide validated and effective treatment for previously untreatable patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">1&#44;2</span></a> Although a variety of devices are now available for treating patients of advanced age and with complex disease&#44; not all patients are suitable candidates for transcatheter aortic valve implantation &#40;TAVI&#41;&#44; and patient selection remains a challenge&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The world&#39;s first TAVI procedure was performed by Alan Cribier in 2002&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> The technique was first used in Portugal five years later in August 2007&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">4</span></a> and since then many other centers have developed a TAVI program&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">5</span></a> There are now as many as eleven functioning TAVI centers in Portugal&#44; which annually perform over 56 procedures per million population&#44; a figure that is growing&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Comorbidity&#44; disability&#44; and frailty are three entities that are particularly associated with elderly candidates&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">6</span></a> The STS&#47;ACC TVT Registry reports that TAVI patients are elderly&#44; highly symptomatic and frail&#44; with multiple comorbidities and advanced functional class&#44; a high Society of Thoracic Surgeons-predicted risk of mortality&#44; and poor self-reported health status&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">7</span></a> Considering all these factors&#44; it is not surprising that a significant percentage of patients die or fail to show improved quality of life in follow-up&#46; The need to optimize the decision-making process in these complex patients has led to increased interaction between different specialties&#46; Thus the concept of the heart team was born and has been widely applied ever since&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The value of a dedicated heart team assessment prior to TAVI is best shown by the team&#39;s ability to bring multidisciplinary clinical expertise to bear on two aspects of patient eligibility&#58; risk stratification and analysis of futility&#46; Integrating these two aspects should allow for better performance in assessing how the patient&#39;s quality of life and survival may be influenced by the valve disease and associated conditions&#44; and in determining the treatment option that best balances risk and benefit&#46; The importance of a heart team assessment is acknowledged in current practice guidelines&#44; but is not reflected in a substantial quantity of publications on real-life applications&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In this issue of the <span class="elsevierStyleItalic">Journal</span>&#44; Costa et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">8</span></a> address the advantages of a systematic multidisciplinary approach to TAVI patients and provide insight into the heart team&#39;s assessment of TAVI candidates in a single large-volume national center&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The authors describe three steps for patient assessment&#58; clinical assessment&#44; non-invasive and invasive tests&#44; and finally a multidisciplinary discussion&#46; For the latter&#44; a multidisciplinary team composed of clinical and interventional cardiologists&#44; experts in cardiac imaging&#44; heart failure specialists and cardiac surgeons meet regularly to define treatment strategies&#46; Notably&#44; the article is co-authored by a multidisciplinary team from different medical centers composed of the above-mentioned areas of expertise&#44; as well as a researcher at the Chronic Diseases Research Center &#40;CEDOC&#41; of Nova Medical School&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The sample included 473 patients from 2008 to 2015&#44; in 383 of whom a heart team assessment was completed&#46; A significant number of patients were selected for surgical aortic valve replacement &#40;SAVR&#41; &#40;20&#46;9&#37;&#41; or for medical therapy alone &#40;23&#46;2&#37;&#41; &#40;overall 169 of 383&#44; 44&#46;1&#37;&#41;&#44; reflecting the wide range of patient complexity&#46; Those undergoing SAVR or TAVI were followed at 30 days&#44; six months and one year after the procedure&#44; and then annually&#59; the authors do not mention a systematic follow-up of patients under medical therapy alone&#44; which was presumably performed by the clinical cardiologist&#46; The criteria for TAVI included inoperability or high surgical risk&#44; and a subjective assessment of lack of futility&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">A simple dedicated TAVI risk score remains an unmet clinical need&#46; Most risk scores were designed for surgical risk&#44; and patients under analysis for TAVI are beyond that stage&#46; Integration with variables such as frailty &#40;including muscle strength&#44; gait speed&#44; weight loss&#44; exhaustion&#44; and level of activity&#41;&#44; the patient&#39;s capacity for self-care&#44; and home oxygen use appear to contribute to more precise stratification&#46; The TAVI<span class="elsevierStyleInf">2</span>-SCORe by Debonnaire et al&#46; stratifies patients into five risk groups for one-year mortality based on a retrospective analysis of 511 individuals who underwent TAVI&#44; with better results than the logistic EuroSCORE&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">9</span></a> Hermiller et al&#46; published a novel score for early and late mortality in extreme-risk and high-risk patients that accurately stratified patients into low&#44; moderate and high risk&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">10</span></a> while Capodanno et al&#46; proposed a simple seven-factor risk tool &#40;the OBSERVANT score&#41; for prediction of 30-day mortality after TAVI&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">11</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In parallel with risk stratification is the development of new tools for predicting clinical futility&#44; and this entails looking at the patient from a different angle&#46; Futility can be defined by the combination of death and&#47;or absence of improvement in functional class during short-term follow-up post-procedure &#40;six months to one year&#41;&#46; Other definitions are possible and this is still a hotly debated topic&#46; Factors influencing futility of treatment include non-cardiovascular conditions such as chronic lung disease &#40;CLD&#41;&#44; advanced chronic kidney disease and frailty&#44; and various cardiovascular conditions&#44; including reduced left ventricular ejection fraction&#44; pulmonary hypertension&#44; low trans-aortic gradient&#44; low-flow state or severe organic mitral regurgitation&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">12</span></a> An analysis of futility has been performed for a Portuguese TAVI population of 340 patients with a mean STS score of 5&#46;67&#177;4&#46;17&#37;&#46; The authors found that age&#44; CLD&#44; New York Heart Association functional class &#8805;III prior to the procedure and a non-transfemoral approach were predictors of futility for this population&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">13</span></a> Apart from its clinical impact&#44; analysis of futility is also closely related to the healthcare costs of TAVI&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Although the TAVI and SAVR groups appear to have performed well in the population analyzed by Costa et al&#46;&#44; there is still room for improvement&#44; as the authors recognize&#46; The fact that many patients died &#40;12&#37; of the study population&#41; while awaiting heart team assessment or TAVI itself is a reminder of the severity of these patients and that appropriate strategies need to provide a more timely response from the healthcare system&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Heart team assessment should not only help clarify which patients are unlikely to benefit from TAVI&#44; but should also translate into a positive effect on healthcare costs&#46; Perhaps one of the most important statements by Costa et al&#46; is that results are continuously monitored and all clinical and procedural data are collected in a dedicated database &#40;Cardiobase&#41; and included in an ongoing registry&#44; the Valve Catheter Restorative Operation on Santa Cruz Hospital &#40;VCROSS&#41;&#46; It is reassuring to know that monitoring of results is taking place&#46; This is critical for self-evaluation and improvement in any system and should be highlighted as a reference for currently implemented systems at other intervention centers&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">To conclude&#44; the accurate measurement of procedural outcomes for TAVI patients should include procedure-related clinical events&#44; and also an assessment of quality of life and functional capacity&#46; In the population analyzed by Costa et al&#46;&#44; an analysis of quality of life and characterization of patients for whom the procedure was deemed futile could expand the analysis of the quality of treatment&#46; Performing this analysis for the population of the national TAVI registry and determining predictors of futility could result in a valuable tool for heart teams in the future&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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Informação do artigo
ISSN: 08702551
Idioma original: Inglês
Dados atualizados diariamente
Ano/Mês Html Pdf Total
2024 Novembro 6 2 8
2024 Outubro 39 29 68
2024 Setembro 53 29 82
2024 Agosto 47 29 76
2024 Julho 48 24 72
2024 Junho 36 30 66
2024 Maio 48 17 65
2024 Abril 47 27 74
2024 Maro 40 25 65
2024 Fevereiro 53 17 70
2024 Janeiro 43 32 75
2023 Dezembro 50 33 83
2023 Novembro 57 42 99
2023 Outubro 41 11 52
2023 Setembro 50 21 71
2023 Agosto 67 21 88
2023 Julho 41 5 46
2023 Junho 47 10 57
2023 Maio 81 33 114
2023 Abril 45 7 52
2023 Maro 66 26 92
2023 Fevereiro 53 22 75
2023 Janeiro 38 13 51
2022 Dezembro 63 31 94
2022 Novembro 88 47 135
2022 Outubro 75 33 108
2022 Setembro 61 40 101
2022 Agosto 68 33 101
2022 Julho 61 50 111
2022 Junho 49 26 75
2022 Maio 48 33 81
2022 Abril 63 38 101
2022 Maro 55 58 113
2022 Fevereiro 53 45 98
2022 Janeiro 51 37 88
2021 Dezembro 40 41 81
2021 Novembro 36 32 68
2021 Outubro 59 50 109
2021 Setembro 58 33 91
2021 Agosto 47 33 80
2021 Julho 23 25 48
2021 Junho 34 25 59
2021 Maio 33 38 71
2021 Abril 39 38 77
2021 Maro 83 33 116
2021 Fevereiro 91 17 108
2021 Janeiro 49 15 64
2020 Dezembro 46 12 58
2020 Novembro 53 15 68
2020 Outubro 53 8 61
2020 Setembro 63 18 81
2020 Agosto 39 15 54
2020 Julho 51 14 65
2020 Junho 45 21 66
2020 Maio 42 4 46
2020 Abril 41 23 64
2020 Maro 37 13 50
2020 Fevereiro 100 32 132
2020 Janeiro 21 6 27
2019 Dezembro 23 8 31
2019 Novembro 37 10 47
2019 Outubro 28 7 35
2019 Setembro 19 8 27
2019 Agosto 24 11 35
2019 Julho 29 16 45
2019 Junho 33 11 44
2019 Maio 41 14 55
2019 Abril 25 12 37
2019 Maro 103 11 114
2019 Fevereiro 67 19 86
2019 Janeiro 49 9 58
2018 Dezembro 27 11 38
2018 Novembro 56 13 69
2018 Outubro 104 26 130
2018 Setembro 31 9 40
2018 Agosto 29 10 39
2018 Julho 10 5 15
2018 Junho 22 8 30
2018 Maio 20 8 28
2018 Abril 29 12 41
2018 Maro 35 7 42
2018 Fevereiro 24 6 30
2018 Janeiro 30 15 45
2017 Dezembro 58 39 97
2017 Novembro 2 8 10
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