array:26 [
  "pii" => "S0870255116303894"
  "issn" => "08702551"
  "doi" => "10.1016/j.repc.2016.12.003"
  "estado" => "S300"
  "fechaPublicacion" => "2017-02-01"
  "aid" => "936"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "dis"
  "cita" => "Rev Port Cardiol. 2017;36:107-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2462
    "formatos" => array:3 [
      "EPUB" => 183
      "HTML" => 1799
      "PDF" => 480
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:20 [
      "pii" => "S2174204917300296"
      "issn" => "21742049"
      "doi" => "10.1016/j.repce.2017.02.005"
      "estado" => "S300"
      "fechaPublicacion" => "2017-02-01"
      "aid" => "936"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "dis"
      "cita" => "Rev Port Cardiol. 2017;36:107-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 1943
        "formatos" => array:3 [
          "EPUB" => 152
          "HTML" => 1447
          "PDF" => 344
        ]
      ]
      "en" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
        "titulo" => "Neutrophil-to-lymphocyte ratio and ambulatory blood pressure&#58; Exploring the link between inflammation and hypertension"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "107"
            "paginaFinal" => "109"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "Rela&#231;&#227;o neutr&#243;filos&#47;linf&#243;citos e press&#227;o arterial ambulat&#243;ria&#46; Explorando a rela&#231;&#227;o entre inflama&#231;&#227;o e hipertens&#227;o"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Jorge Pol&#243;nia"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "Jorge"
                "apellidos" => "Pol&#243;nia"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0870255116303894"
          "doi" => "10.1016/j.repc.2016.12.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116303894?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204917300296?idApp=UINPBA00004E"
      "url" => "/21742049/0000003600000002/v1_201702240018/S2174204917300296/v1_201702240018/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S0870255116302153"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2016.08.005"
    "estado" => "S300"
    "fechaPublicacion" => "2017-02-01"
    "aid" => "888"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Cardiol. 2017;36:111-25"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4011
      "formatos" => array:3 [
        "EPUB" => 211
        "HTML" => 3263
        "PDF" => 537
      ]
    ]
    "pt" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original</span>"
      "titulo" => "Estratifica&#231;&#227;o progn&#243;stica na hipertens&#227;o pulmonar&#58; valor acrescido da abordagem multibiomarcadores"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => "pt"
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "111"
          "paginaFinal" => "125"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Prognostic stratification in pulmonary hypertension&#58; A multi&#8208;biomarker approach"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figura 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 3803
              "Ancho" => 3125
              "Tamanyo" => 554682
            ]
          ]
          "descripcion" => array:1 [
            "pt" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Curvas ROC dos diferentes biomarcadores relativamente &#224; predi&#231;&#227;o de morte e morte ou internamento por causa card&#237;aca aos tr&#234;s anos&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rui Pl&#225;cido, Nuno Cortez&#8208;Dias, Susana Robalo Martins, Ana Gomes Almeida, Carina Calisto, Susana Gon&#231;alves, Malha Sadoune, Ant&#243;nio Nunes Diogo, Alexandre Mebazaa, Fausto Jos&#233; Pinto"
          "autores" => array:10 [
            0 => array:2 [
              "nombre" => "Rui"
              "apellidos" => "Pl&#225;cido"
            ]
            1 => array:2 [
              "nombre" => "Nuno"
              "apellidos" => "Cortez&#8208;Dias"
            ]
            2 => array:2 [
              "nombre" => "Susana"
              "apellidos" => "Robalo Martins"
            ]
            3 => array:2 [
              "nombre" => "Ana"
              "apellidos" => "Gomes Almeida"
            ]
            4 => array:2 [
              "nombre" => "Carina"
              "apellidos" => "Calisto"
            ]
            5 => array:2 [
              "nombre" => "Susana"
              "apellidos" => "Gon&#231;alves"
            ]
            6 => array:2 [
              "nombre" => "Malha"
              "apellidos" => "Sadoune"
            ]
            7 => array:2 [
              "nombre" => "Ant&#243;nio"
              "apellidos" => "Nunes Diogo"
            ]
            8 => array:2 [
              "nombre" => "Alexandre"
              "apellidos" => "Mebazaa"
            ]
            9 => array:2 [
              "nombre" => "Fausto Jos&#233;"
              "apellidos" => "Pinto"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2174204916302665"
        "doi" => "10.1016/j.repce.2016.12.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204916302665?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116302153?idApp=UINPBA00004E"
    "url" => "/08702551/0000003600000002/v1_201702090011/S0870255116302153/v1_201702090011/pt/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S0870255116303869"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2016.07.009"
    "estado" => "S300"
    "fechaPublicacion" => "2017-02-01"
    "aid" => "934"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Cardiol. 2017;36:97-105"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2194
      "formatos" => array:3 [
        "EPUB" => 228
        "HTML" => 1467
        "PDF" => 499
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "The relationship between 24-hour ambulatory blood pressure load and neutrophil-to-lymphocyte ratio"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "97"
          "paginaFinal" => "105"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "A rela&#231;&#227;o entre a carga da press&#227;o arterial em ambulat&#243;rio durante 24 horas e a propor&#231;&#227;o neutr&#243;filos&#47;linf&#243;citos"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2697
              "Ancho" => 3353
              "Tamanyo" => 698912
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Pearson&#39;s correlation analysis demonstrating correlations between NLR and &#40;A&#41; 24-hour systolic BP&#59; &#40;B&#41; 24-hour systolic BP load&#59; &#40;C&#41; 24-hour diastolic BP&#59; and &#40;D&#41; 24-hour diastolic BP load&#46; BP&#58; blood pressure&#59; NLR&#58; neutrophil-to-lymphocyte ratio&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Tolga &#199;imen, Hamza Sunman, Tolga Han Efe, Mehmet Erat, Haluk Furkan &#350;ahan, Engin Alg&#252;l, &#304;lkin Guliyev, Ahmet Akyel, Mehmet Do&#287;an, Sad&#305;k A&#231;&#305;kel, Ekrem Yeter"
          "autores" => array:11 [
            0 => array:2 [
              "nombre" => "Tolga"
              "apellidos" => "&#199;imen"
            ]
            1 => array:2 [
              "nombre" => "Hamza"
              "apellidos" => "Sunman"
            ]
            2 => array:2 [
              "nombre" => "Tolga Han"
              "apellidos" => "Efe"
            ]
            3 => array:2 [
              "nombre" => "Mehmet"
              "apellidos" => "Erat"
            ]
            4 => array:2 [
              "nombre" => "Haluk Furkan"
              "apellidos" => "&#350;ahan"
            ]
            5 => array:2 [
              "nombre" => "Engin"
              "apellidos" => "Alg&#252;l"
            ]
            6 => array:2 [
              "nombre" => "&#304;lkin"
              "apellidos" => "Guliyev"
            ]
            7 => array:2 [
              "nombre" => "Ahmet"
              "apellidos" => "Akyel"
            ]
            8 => array:2 [
              "nombre" => "Mehmet"
              "apellidos" => "Do&#287;an"
            ]
            9 => array:2 [
              "nombre" => "Sad&#305;k"
              "apellidos" => "A&#231;&#305;kel"
            ]
            10 => array:2 [
              "nombre" => "Ekrem"
              "apellidos" => "Yeter"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2174204917300272"
        "doi" => "10.1016/j.repce.2017.02.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204917300272?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116303869?idApp=UINPBA00004E"
    "url" => "/08702551/0000003600000002/v1_201702090011/S0870255116303869/v1_201702090011/en/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:20 [
      "pii" => "S0870255116303869"
      "issn" => "08702551"
      "doi" => "10.1016/j.repc.2016.07.009"
      "estado" => "S300"
      "fechaPublicacion" => "2017-02-01"
      "aid" => "934"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Rev Port Cardiol. 2017;36:97-105"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 2194
        "formatos" => array:3 [
          "EPUB" => 228
          "HTML" => 1467
          "PDF" => 499
        ]
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
        "titulo" => "The relationship between 24-hour ambulatory blood pressure load and neutrophil-to-lymphocyte ratio"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "pt"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "97"
            "paginaFinal" => "105"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "A rela&#231;&#227;o entre a carga da press&#227;o arterial em ambulat&#243;rio durante 24 horas e a propor&#231;&#227;o neutr&#243;filos&#47;linf&#243;citos"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "pt" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figure 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2697
                "Ancho" => 3353
                "Tamanyo" => 698912
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Pearson&#39;s correlation analysis demonstrating correlations between NLR and &#40;A&#41; 24-hour systolic BP&#59; &#40;B&#41; 24-hour systolic BP load&#59; &#40;C&#41; 24-hour diastolic BP&#59; and &#40;D&#41; 24-hour diastolic BP load&#46; BP&#58; blood pressure&#59; NLR&#58; neutrophil-to-lymphocyte ratio&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Tolga &#199;imen, Hamza Sunman, Tolga Han Efe, Mehmet Erat, Haluk Furkan &#350;ahan, Engin Alg&#252;l, &#304;lkin Guliyev, Ahmet Akyel, Mehmet Do&#287;an, Sad&#305;k A&#231;&#305;kel, Ekrem Yeter"
            "autores" => array:11 [
              0 => array:2 [
                "nombre" => "Tolga"
                "apellidos" => "&#199;imen"
              ]
              1 => array:2 [
                "nombre" => "Hamza"
                "apellidos" => "Sunman"
              ]
              2 => array:2 [
                "nombre" => "Tolga Han"
                "apellidos" => "Efe"
              ]
              3 => array:2 [
                "nombre" => "Mehmet"
                "apellidos" => "Erat"
              ]
              4 => array:2 [
                "nombre" => "Haluk Furkan"
                "apellidos" => "&#350;ahan"
              ]
              5 => array:2 [
                "nombre" => "Engin"
                "apellidos" => "Alg&#252;l"
              ]
              6 => array:2 [
                "nombre" => "&#304;lkin"
                "apellidos" => "Guliyev"
              ]
              7 => array:2 [
                "nombre" => "Ahmet"
                "apellidos" => "Akyel"
              ]
              8 => array:2 [
                "nombre" => "Mehmet"
                "apellidos" => "Do&#287;an"
              ]
              9 => array:2 [
                "nombre" => "Sad&#305;k"
                "apellidos" => "A&#231;&#305;kel"
              ]
              10 => array:2 [
                "nombre" => "Ekrem"
                "apellidos" => "Yeter"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2174204917300272"
          "doi" => "10.1016/j.repce.2017.02.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204917300272?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116303869?idApp=UINPBA00004E"
      "url" => "/08702551/0000003600000002/v1_201702090011/S0870255116303869/v1_201702090011/en/main.assets"
    ]
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
    "titulo" => "Neutrophil-to-lymphocyte ratio and ambulatory blood pressure&#58; Exploring the link between inflammation and hypertension"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "107"
        "paginaFinal" => "109"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Jorge Pol&#243;nia"
        "autores" => array:1 [
          0 => array:4 [
            "nombre" => "Jorge"
            "apellidos" => "Pol&#243;nia"
            "email" => array:1 [
              0 => "jjpolonia&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Departamento de Medicina e Cintesis&#44; Faculdade de Medicina da Universidade do Porto&#44; Porto&#44; Portugal"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidade Hipertens&#227;o e Risco Cardiovascular do Hospital Pedro Hispano&#44; Matosinhos&#44; Portugal"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Rela&#231;&#227;o neutr&#243;filos&#47;linf&#243;citos e press&#227;o arterial ambulat&#243;ria&#46; Explorando a rela&#231;&#227;o entre inflama&#231;&#227;o e hipertens&#227;o"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In the last decade a strong and definitive link has been established between inflammation and cardiovascular disease&#46; Inflammation occurs in the vasculature as a response to several types of injury&#46; Various risk factors&#44; including hypertension&#44; diabetes&#44; and smoking&#44; together with oxidized low-density lipoprotein cholesterol&#44; trigger a chronic inflammatory reaction&#44; the result of which is a vulnerable plaque&#44; prone to rupture and thrombosis&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">1</span></a> Epidemiological and clinical studies have consistently shown links between markers of inflammation and risk of future cardiovascular events&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">1</span></a> Activation of macrophages&#44; T lymphocytes&#44; and smooth muscle cells leads to the release of additional mediators&#44; including adhesion molecules&#44; cytokines&#44; chemokines&#44; and growth factors&#44; all of which play important roles in atherogenesis&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">2</span></a> Inflammation plays a role in all stages of atherothrombosis&#44; the underlying cause of approximately 80&#37; of all sudden cardiac deaths&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The study by &#199;imen et al&#46; published in this issue of the <span class="elsevierStyleItalic">Journal</span><a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">4</span></a> examines the relationship between 24-hour ambulatory blood pressure &#40;BP&#41; and a systemic inflammation marker&#44; the neutrophil-to-lymphocyte ratio &#40;NLR&#41;&#46; The authors claim to have shown for the first time that an increased NLR is independently associated with the severity of hypertension &#40;HTN&#41; in patients with untreated essential HTN&#46; NLR is considered a marker of inflammatory status<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">5</span></a> and has been shown to predict risk of coronary disease&#44;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">6</span></a> heart failure<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">7</span></a> and stroke&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">8</span></a> and has been associated with resistant hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">9</span></a> Since HTN is a significant risk factor in inflammatory conditions such as atherosclerosis<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">5</span></a> and inflammatory molecules such as C-reactive protein &#40;CRP&#41;&#44; vascular and intercellular adhesion molecules&#44; monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1 are increased in HTN&#44;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">10&#44;11</span></a> the finding of a proportional increase of NLR with higher severity of HTN fits with the hypothesis of the inflammatory nature of hypertensive disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">12&#8211;14</span></a> Because inflammation may have a role in the pathogenesis and progression of hypertension&#44;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">10&#44;11</span></a> the authors speculate that an increase in this inflammatory marker &#40;which can be easily measured in clinical practice&#41; may help to predict HTN severity and to guide therapy in hypertensive patients&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Other indices derived from blood count parameters have also been identified as inflammatory markers&#44; including red cell distribution width &#40;RDW&#41;&#44; mean platelet volume &#40;MPV&#41; and platelet-to-lymphocyte ratio &#40;PLR&#41;&#44; and some have been associated with different degrees of hypertension severity&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">15&#8211;17</span></a> Some authors have shown that patients with non-dipper hypertension have higher NLR and PLR than those with dipper hypertension&#44; although only PLR &#40;not NLR&#41; was found to be an independent predictor of non-dipper status&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">18</span></a> The most striking aspect of the present study is that HTN was defined on the basis of 24-hour ambulatory BP measurement&#44; in contrast to other authors who used only the less accurate office BP and failed to find any difference in NLR between normotensives and hypertensives&#46; In this study&#44; log NLR values were found to be weakly but positively correlated with 24-hour systolic blood pressure &#40;SBP&#41;&#44; diastolic blood pressure &#40;DBP&#41;&#44; SBP load and DBP load&#44; while in multivariate analysis&#44; log NLR had an independent association with 24-hour BP and 24-hour BP load&#46; However&#44; one of the major limitations of this type of cross-sectional study lies in the general difficulty of proving causal relationships between variables merely because they appear to be associated in proportion&#46; It is always possible that the relationship between these variables is not direct but rather an epiphenomenon&#46; While not questioning the merit or the novelty of the present study&#44; it would have been of considerable interest to determine whether other inflammatory markers which can be easily measured in clinical practice&#44; such as CRP&#44; RDW&#44; MPV&#44; PLR and leukocyte activation markers&#44; were also seen to be associated with ambulatory HTN&#44; which could thereby have confirmed the coherence&#44; correspondence and validity of the observed data in this population&#46; Also in this context it would have been useful to calculate a receiver operating characteristic curve of the diagnostic value of NLR for HTN&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">There is however another finding in this study that deserves some comment&#46; In the interquartile analysis of the NLR distribution&#44; the authors found a relationship between NLR&#44; firstly predominantly with daytime and 24-hour BP values and daytime BP load but not with nighttime BP values&#44; and secondly predominantly with DBP but much less with DBP&#46; This is quite atypical&#46; In several studies<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">19&#8211;24</span></a> nighttime SBP and SBP vs&#46; DBP have been clearly shown to be the strongest independent predictors of cardiovascular events and prognosis among the different indices of BP measurement&#46; We may ask why the relationships established in the present study with NLR were not mainly seen with the BP indices that are better determinants of cardiovascular risk &#40;nighttime and systolic BP&#41; but rather with daytime BP and with others with inferior reproducibility and lower predictive value &#40;BP load and diastolic BP&#41;&#46; One possible speculative explanation for this atypical finding may be the existence of a circadian rhythm of inflammatory immune responses&#44; with day-to-day and day-to-night fluctuations in immune responses to stress&#46; A number of studies have suggested that sleep disorders such as sleep loss&#44; narcolepsy&#44; and sleep apnea are associated with elevated inflammatory markers such as interleukin 6&#44; tumor necrosis factor-alpha&#44; CRP&#44; and white blood cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">25&#8211;27</span></a> For example it has been shown<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">28</span></a> that at the molecular level&#44; &#62;8&#37; of the macrophage transcriptome oscillates in a circadian fashion&#44; including many important regulators for pathogen recognition and cytokine secretion&#46; In addition&#44; time-of-day-dependent fluctuations in the number of neutrophils are not always in line with those of lymphocytes<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">29</span></a> and changes in NLR may be different during day and night&#46; We do not know whether a different NLR measured in blood samples collected at night rather than in the morning could indicate a closer relationship between NLR and nighttime BP values&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A systematic search for inflammatory markers that could enable early detection of the presence of hypertension and its complications in a simple routine blood count is a fascinating challenge&#46; The study by &#199;imen et al&#46; is within this context&#46; However&#44; further research is needed to precisely determine the scientific robustness of the diagnostic and prognostic value of the association between NLR and HTN at the various stages of the evolution of the disease&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:29 [
            0 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation as a cardiovascular risk factor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;T&#46; Willerson"
                            1 => "P&#46;M&#46; Ridker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR.0000129535.04194.38"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2004"
                        "volumen" => "109"
                        "paginaInicial" => "II2"
                        "paginaFinal" => "II10"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15173056"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Novel inflammatory markers of coronary risk&#58; theory versus practice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Libby"
                            1 => "P&#46;M&#46; Ridker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1999"
                        "volumen" => "100"
                        "paginaInicial" => "1148"
                        "paginaFinal" => "1150"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10484532"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prospective study of C-reactive protein&#44; homocysteine&#44; and plasma lipid levels as predictors of sudden cardiac death"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;M&#46; Albert"
                            1 => "J&#46; Ma"
                            2 => "N&#46; Rifai"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2002"
                        "volumen" => "105"
                        "paginaInicial" => "2595"
                        "paginaFinal" => "2599"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12045163"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship between 24-hour ambulatory blood pressure load and neutrophil to lymphocyte ratio"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46; &#199;imen"
                            1 => "H&#46; Sunman"
                            2 => "T&#46; Han Efe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Port Cardiol"
                        "fecha" => "2017"
                        "volumen" => "36"
                        "paginaInicial" => "97"
                        "paginaFinal" => "105"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "F&#46; Imtiaz"
                            1 => "K&#46; Shafique"
                            2 => "S&#46;S&#46; Mirza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Int Archiv Med"
                        "fecha" => "2012"
                        "volumen" => "5"
                        "paginaInicial" => "2"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil-to-lymphocyte ratio predicts hemodynamic significance of coronary artery stenosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Akyel"
                            1 => "C&#46; Yayla"
                            2 => "M&#46; Erat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5152/akd.2015.5909"
                      "Revista" => array:6 [
                        "tituloSerie" => "Anatol J Cardiol"
                        "fecha" => "2015"
                        "volumen" => "15"
                        "paginaInicial" => "1002"
                        "paginaFinal" => "1007"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25880055"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usefulness of neutrophil-to-lymphocyte ratio in risk stratification of patients with advanced heart failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "V&#46;A&#46; Benites-Zapata"
                            1 => "A&#46;V&#46; Hernandez"
                            2 => "V&#46; Nagarajan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2014.10.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2015"
                        "volumen" => "115"
                        "paginaInicial" => "57"
                        "paginaFinal" => "61"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25456873"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is elevated neutrophil-to-lymphocyte ratio a predictor of stroke in patients with intermediate carotid artery stenosis&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46; Koklu"
                            1 => "I&#46;O&#46; Yuksel"
                            2 => "S&#46; Arslan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jstrokecerebrovasdis.2015.10.031"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Stroke Cerebrovasc Dis"
                        "fecha" => "2016"
                        "volumen" => "25"
                        "paginaInicial" => "578"
                        "paginaFinal" => "584"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26706445"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased neutrophil to lymphocyte ratio in patients with resistant hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46; Belen"
                            1 => "A&#46; Sungur"
                            2 => "M&#46;A&#46; Sungur"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Hypertens &#40;Greenwich&#41;"
                        "fecha" => "2015"
                        "volumen" => "17"
                        "paginaInicial" => "532"
                        "paginaFinal" => "537"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Cottone"
                            1 => "G&#46; Mule"
                            2 => "E&#46; Nardi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjhyper.2005.09.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hypertens"
                        "fecha" => "2006"
                        "volumen" => "19"
                        "paginaInicial" => "313"
                        "paginaFinal" => "318"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16500520"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abnormalities of vascular function in resistant hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; de La Sierra"
                            1 => "M&#46; Larrousse"
                            2 => "A&#46; Oliveras"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/08037051.2011.622983"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood Press"
                        "fecha" => "2012"
                        "volumen" => "21"
                        "paginaInicial" => "104"
                        "paginaFinal" => "109"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22017418"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Markers of inflammation&#44; endothelial activation&#44; and arterial stiffness in hypertensive heart disease and the effects of treatment&#58; results from the SILVHIA study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Jekell"
                            1 => "K&#46; Malmqvist"
                            2 => "N&#46;H&#46; Wallen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/FJC.0000000000000017"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cardiovasc Pharmacol"
                        "fecha" => "2013"
                        "volumen" => "62"
                        "paginaInicial" => "559"
                        "paginaFinal" => "566"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24084214"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IL-1beta and IL-18&#58; inflammatory markers or mediators of hypertension&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;M&#46; Krishnan"
                            1 => "C&#46;G&#46; Sobey"
                            2 => "E&#46; Latz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bph.12876"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Pharmacol"
                        "fecha" => "2014"
                        "volumen" => "171"
                        "paginaInicial" => "5589"
                        "paginaFinal" => "5602"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25117218"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation in hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Savoia"
                            1 => "E&#46;L&#46; Schiffrin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.mnh.0000203189.57513.76"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Nephrol Hypertens"
                        "fecha" => "2006"
                        "volumen" => "15"
                        "paginaInicial" => "152"
                        "paginaFinal" => "158"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16481882"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mean platelet volume in patients with dipper and non-dipper hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Ordu"
                            1 => "H&#46; Ozhan"
                            2 => "O&#46; Caglar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/08037050903416402"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood Press"
                        "fecha" => "2010"
                        "volumen" => "19"
                        "paginaInicial" => "26"
                        "paginaFinal" => "30"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19929284"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Red cell distribution width and inflammation in patients with non-dipper hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "F&#46; Ozcan"
                            1 => "O&#46; Turak"
                            2 => "A&#46; Durak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/08037051.2012.707336"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood Press"
                        "fecha" => "2013"
                        "volumen" => "22"
                        "paginaInicial" => "80"
                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22835009"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "U&#46;U&#46; Tamhane"
                            1 => "S&#46; Aneja"
                            2 => "D&#46; Montgomery"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2008.05.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2008"
                        "volumen" => "102"
                        "paginaInicial" => "653"
                        "paginaFinal" => "657"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18773982"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Sunbul"
                            1 => "F&#46; Gerin"
                            2 => "E&#46; Durmus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/10641963.2013.804547"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Hypertens"
                        "fecha" => "2014"
                        "volumen" => "36"
                        "paginaInicial" => "217"
                        "paginaFinal" => "221"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23786430"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Value of ambulatory arterial pressure monitoring in the prediction of target-organ damage and cardiovascular events"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;C&#46; Hermida"
                            1 => "D&#46;E&#46; Ayala"
                            2 => "C&#46; Calvo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2002"
                        "volumen" => "22"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "59"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12014304"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "discussion 40"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic impact from clinic&#44; daytime&#44; and night-time systolic blood pressure in nine cohorts of 13&#44;844 patients with hypertension"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "ABC-H Investigators"
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46;C&#46; Roush"
                            1 => "R&#46;H&#46; Fagard"
                            2 => "G&#46;F&#46; Salles"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/HJH.0000000000000355"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2014"
                        "volumen" => "32"
                        "paginaInicial" => "2332"
                        "paginaFinal" => "2340"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25333682"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stroke prognosis and abnormal nocturnal blood pressure falls in older hypertensives"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Kario"
                            1 => "T&#46;G&#46; Pickering"
                            2 => "T&#46; Matsuo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2001"
                        "volumen" => "38"
                        "paginaInicial" => "852"
                        "paginaFinal" => "857"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11641298"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular prognostic value of ambulatory blood pressure monitoring in a Portuguese hypertensive population followed up for 8&#46;2 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Mesquita-Bastos"
                            1 => "S&#46; Bertoquini"
                            2 => "J&#46; Polonia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MBP.0b013e32833c8b08"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood Press Monit"
                        "fecha" => "2010"
                        "volumen" => "15"
                        "paginaInicial" => "240"
                        "paginaFinal" => "246"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20616705"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic effect of the nocturnal blood pressure fall in hypertensive patients&#58; the Ambulatory Blood Pressure Collaboration in Patients With Hypertension &#40;ABC-H&#41; meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46;F&#46; Salles"
                            1 => "G&#46; Reboldi"
                            2 => "R&#46;H&#46; Fagard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/HYPERTENSIONAHA.115.06981"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2016"
                        "volumen" => "67"
                        "paginaInicial" => "693"
                        "paginaFinal" => "700"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26902495"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ambulatory pulse pressure as predictor of outcome in older patients with systolic hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;A&#46; Staessen"
                            1 => "L&#46; Thijs"
                            2 => "E&#46;T&#46; O&#8217;Brien"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hypertens"
                        "fecha" => "2002"
                        "volumen" => "15"
                        "paginaInicial" => "835"
                        "paginaFinal" => "843"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12372669"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased plasma level of tumor necrosis factor alpha in patients with narcolepsy in Taiwan"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46;H&#46; Chen"
                            1 => "Y&#46;S&#46; Huang"
                            2 => "C&#46;H&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.sleep.2013.04.030"
                      "Revista" => array:6 [
                        "tituloSerie" => "Sleep Med"
                        "fecha" => "2013"
                        "volumen" => "14"
                        "paginaInicial" => "1272"
                        "paginaFinal" => "1276"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24157100"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;R&#46; Irwin"
                            1 => "M&#46; Wang"
                            2 => "C&#46;O&#46; Campomayor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archinte.166.16.1756"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "2006"
                        "volumen" => "166"
                        "paginaInicial" => "1756"
                        "paginaFinal" => "1762"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16983055"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin-6 and cortisol levels&#58; physiologic and therapeutic implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;N&#46; Vgontzas"
                            1 => "M&#46; Zoumakis"
                            2 => "E&#46;O&#46; Bixler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2002-021176"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2003"
                        "volumen" => "88"
                        "paginaInicial" => "2087"
                        "paginaFinal" => "2095"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12727959"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A circadian clock in macrophages controls inflammatory immune responses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Keller"
                            1 => "J&#46; Mazuch"
                            2 => "U&#46; Abraham"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1073/pnas.0906361106"
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci U S A"
                        "fecha" => "2009"
                        "volumen" => "106"
                        "paginaInicial" => "21407"
                        "paginaFinal" => "21412"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19955445"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Circadian rhythm of leucocytes and lymphocytes subsets and its possible correlation with the function of the autonomic nervous system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Suzuki"
                            1 => "S&#46; Toyabe"
                            2 => "T&#46; Moroda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Immunol"
                        "fecha" => "1997"
                        "volumen" => "110"
                        "paginaInicial" => "500"
                        "paginaFinal" => "508"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9409657"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/08702551/0000003600000002/v1_201702090011/S0870255116303894/v1_201702090011/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "29261"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Artigos Originais"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08702551/0000003600000002/v1_201702090011/S0870255116303894/v1_201702090011/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116303894?idApp=UINPBA00004E"
]
Partilhar
Informação da revista

Estatísticas

Siga este link para acessar o texto completo do artigo

Editorial comment
Neutrophil-to-lymphocyte ratio and ambulatory blood pressure: Exploring the link between inflammation and hypertension
Relação neutrófilos/linfócitos e pressão arterial ambulatória. Explorando a relação entre inflamação e hipertensão
Jorge Polóniaa,b
a Departamento de Medicina e Cintesis, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
b Unidade Hipertensão e Risco Cardiovascular do Hospital Pedro Hispano, Matosinhos, Portugal
Lido
6328
Vezes
que se leu este artigo
1915
Total PDF
4413
Total HTML
Compartilhar estatísticas
 array:26 [
  "pii" => "S0870255116303894"
  "issn" => "08702551"
  "doi" => "10.1016/j.repc.2016.12.003"
  "estado" => "S300"
  "fechaPublicacion" => "2017-02-01"
  "aid" => "936"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "dis"
  "cita" => "Rev Port Cardiol. 2017;36:107-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2462
    "formatos" => array:3 [
      "EPUB" => 183
      "HTML" => 1799
      "PDF" => 480
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:20 [
      "pii" => "S2174204917300296"
      "issn" => "21742049"
      "doi" => "10.1016/j.repce.2017.02.005"
      "estado" => "S300"
      "fechaPublicacion" => "2017-02-01"
      "aid" => "936"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "dis"
      "cita" => "Rev Port Cardiol. 2017;36:107-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 1943
        "formatos" => array:3 [
          "EPUB" => 152
          "HTML" => 1447
          "PDF" => 344
        ]
      ]
      "en" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
        "titulo" => "Neutrophil-to-lymphocyte ratio and ambulatory blood pressure&#58; Exploring the link between inflammation and hypertension"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "107"
            "paginaFinal" => "109"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "Rela&#231;&#227;o neutr&#243;filos&#47;linf&#243;citos e press&#227;o arterial ambulat&#243;ria&#46; Explorando a rela&#231;&#227;o entre inflama&#231;&#227;o e hipertens&#227;o"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Jorge Pol&#243;nia"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "Jorge"
                "apellidos" => "Pol&#243;nia"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0870255116303894"
          "doi" => "10.1016/j.repc.2016.12.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116303894?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204917300296?idApp=UINPBA00004E"
      "url" => "/21742049/0000003600000002/v1_201702240018/S2174204917300296/v1_201702240018/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S0870255116302153"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2016.08.005"
    "estado" => "S300"
    "fechaPublicacion" => "2017-02-01"
    "aid" => "888"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Cardiol. 2017;36:111-25"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4011
      "formatos" => array:3 [
        "EPUB" => 211
        "HTML" => 3263
        "PDF" => 537
      ]
    ]
    "pt" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original</span>"
      "titulo" => "Estratifica&#231;&#227;o progn&#243;stica na hipertens&#227;o pulmonar&#58; valor acrescido da abordagem multibiomarcadores"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => "pt"
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "111"
          "paginaFinal" => "125"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Prognostic stratification in pulmonary hypertension&#58; A multi&#8208;biomarker approach"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figura 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 3803
              "Ancho" => 3125
              "Tamanyo" => 554682
            ]
          ]
          "descripcion" => array:1 [
            "pt" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Curvas ROC dos diferentes biomarcadores relativamente &#224; predi&#231;&#227;o de morte e morte ou internamento por causa card&#237;aca aos tr&#234;s anos&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rui Pl&#225;cido, Nuno Cortez&#8208;Dias, Susana Robalo Martins, Ana Gomes Almeida, Carina Calisto, Susana Gon&#231;alves, Malha Sadoune, Ant&#243;nio Nunes Diogo, Alexandre Mebazaa, Fausto Jos&#233; Pinto"
          "autores" => array:10 [
            0 => array:2 [
              "nombre" => "Rui"
              "apellidos" => "Pl&#225;cido"
            ]
            1 => array:2 [
              "nombre" => "Nuno"
              "apellidos" => "Cortez&#8208;Dias"
            ]
            2 => array:2 [
              "nombre" => "Susana"
              "apellidos" => "Robalo Martins"
            ]
            3 => array:2 [
              "nombre" => "Ana"
              "apellidos" => "Gomes Almeida"
            ]
            4 => array:2 [
              "nombre" => "Carina"
              "apellidos" => "Calisto"
            ]
            5 => array:2 [
              "nombre" => "Susana"
              "apellidos" => "Gon&#231;alves"
            ]
            6 => array:2 [
              "nombre" => "Malha"
              "apellidos" => "Sadoune"
            ]
            7 => array:2 [
              "nombre" => "Ant&#243;nio"
              "apellidos" => "Nunes Diogo"
            ]
            8 => array:2 [
              "nombre" => "Alexandre"
              "apellidos" => "Mebazaa"
            ]
            9 => array:2 [
              "nombre" => "Fausto Jos&#233;"
              "apellidos" => "Pinto"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2174204916302665"
        "doi" => "10.1016/j.repce.2016.12.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204916302665?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116302153?idApp=UINPBA00004E"
    "url" => "/08702551/0000003600000002/v1_201702090011/S0870255116302153/v1_201702090011/pt/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S0870255116303869"
    "issn" => "08702551"
    "doi" => "10.1016/j.repc.2016.07.009"
    "estado" => "S300"
    "fechaPublicacion" => "2017-02-01"
    "aid" => "934"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Cardiol. 2017;36:97-105"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2194
      "formatos" => array:3 [
        "EPUB" => 228
        "HTML" => 1467
        "PDF" => 499
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "The relationship between 24-hour ambulatory blood pressure load and neutrophil-to-lymphocyte ratio"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "97"
          "paginaFinal" => "105"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "A rela&#231;&#227;o entre a carga da press&#227;o arterial em ambulat&#243;rio durante 24 horas e a propor&#231;&#227;o neutr&#243;filos&#47;linf&#243;citos"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2697
              "Ancho" => 3353
              "Tamanyo" => 698912
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Pearson&#39;s correlation analysis demonstrating correlations between NLR and &#40;A&#41; 24-hour systolic BP&#59; &#40;B&#41; 24-hour systolic BP load&#59; &#40;C&#41; 24-hour diastolic BP&#59; and &#40;D&#41; 24-hour diastolic BP load&#46; BP&#58; blood pressure&#59; NLR&#58; neutrophil-to-lymphocyte ratio&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Tolga &#199;imen, Hamza Sunman, Tolga Han Efe, Mehmet Erat, Haluk Furkan &#350;ahan, Engin Alg&#252;l, &#304;lkin Guliyev, Ahmet Akyel, Mehmet Do&#287;an, Sad&#305;k A&#231;&#305;kel, Ekrem Yeter"
          "autores" => array:11 [
            0 => array:2 [
              "nombre" => "Tolga"
              "apellidos" => "&#199;imen"
            ]
            1 => array:2 [
              "nombre" => "Hamza"
              "apellidos" => "Sunman"
            ]
            2 => array:2 [
              "nombre" => "Tolga Han"
              "apellidos" => "Efe"
            ]
            3 => array:2 [
              "nombre" => "Mehmet"
              "apellidos" => "Erat"
            ]
            4 => array:2 [
              "nombre" => "Haluk Furkan"
              "apellidos" => "&#350;ahan"
            ]
            5 => array:2 [
              "nombre" => "Engin"
              "apellidos" => "Alg&#252;l"
            ]
            6 => array:2 [
              "nombre" => "&#304;lkin"
              "apellidos" => "Guliyev"
            ]
            7 => array:2 [
              "nombre" => "Ahmet"
              "apellidos" => "Akyel"
            ]
            8 => array:2 [
              "nombre" => "Mehmet"
              "apellidos" => "Do&#287;an"
            ]
            9 => array:2 [
              "nombre" => "Sad&#305;k"
              "apellidos" => "A&#231;&#305;kel"
            ]
            10 => array:2 [
              "nombre" => "Ekrem"
              "apellidos" => "Yeter"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2174204917300272"
        "doi" => "10.1016/j.repce.2017.02.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204917300272?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116303869?idApp=UINPBA00004E"
    "url" => "/08702551/0000003600000002/v1_201702090011/S0870255116303869/v1_201702090011/en/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:20 [
      "pii" => "S0870255116303869"
      "issn" => "08702551"
      "doi" => "10.1016/j.repc.2016.07.009"
      "estado" => "S300"
      "fechaPublicacion" => "2017-02-01"
      "aid" => "934"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Rev Port Cardiol. 2017;36:97-105"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 2194
        "formatos" => array:3 [
          "EPUB" => 228
          "HTML" => 1467
          "PDF" => 499
        ]
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
        "titulo" => "The relationship between 24-hour ambulatory blood pressure load and neutrophil-to-lymphocyte ratio"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "pt"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "97"
            "paginaFinal" => "105"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "A rela&#231;&#227;o entre a carga da press&#227;o arterial em ambulat&#243;rio durante 24 horas e a propor&#231;&#227;o neutr&#243;filos&#47;linf&#243;citos"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "pt" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figure 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2697
                "Ancho" => 3353
                "Tamanyo" => 698912
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Pearson&#39;s correlation analysis demonstrating correlations between NLR and &#40;A&#41; 24-hour systolic BP&#59; &#40;B&#41; 24-hour systolic BP load&#59; &#40;C&#41; 24-hour diastolic BP&#59; and &#40;D&#41; 24-hour diastolic BP load&#46; BP&#58; blood pressure&#59; NLR&#58; neutrophil-to-lymphocyte ratio&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Tolga &#199;imen, Hamza Sunman, Tolga Han Efe, Mehmet Erat, Haluk Furkan &#350;ahan, Engin Alg&#252;l, &#304;lkin Guliyev, Ahmet Akyel, Mehmet Do&#287;an, Sad&#305;k A&#231;&#305;kel, Ekrem Yeter"
            "autores" => array:11 [
              0 => array:2 [
                "nombre" => "Tolga"
                "apellidos" => "&#199;imen"
              ]
              1 => array:2 [
                "nombre" => "Hamza"
                "apellidos" => "Sunman"
              ]
              2 => array:2 [
                "nombre" => "Tolga Han"
                "apellidos" => "Efe"
              ]
              3 => array:2 [
                "nombre" => "Mehmet"
                "apellidos" => "Erat"
              ]
              4 => array:2 [
                "nombre" => "Haluk Furkan"
                "apellidos" => "&#350;ahan"
              ]
              5 => array:2 [
                "nombre" => "Engin"
                "apellidos" => "Alg&#252;l"
              ]
              6 => array:2 [
                "nombre" => "&#304;lkin"
                "apellidos" => "Guliyev"
              ]
              7 => array:2 [
                "nombre" => "Ahmet"
                "apellidos" => "Akyel"
              ]
              8 => array:2 [
                "nombre" => "Mehmet"
                "apellidos" => "Do&#287;an"
              ]
              9 => array:2 [
                "nombre" => "Sad&#305;k"
                "apellidos" => "A&#231;&#305;kel"
              ]
              10 => array:2 [
                "nombre" => "Ekrem"
                "apellidos" => "Yeter"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2174204917300272"
          "doi" => "10.1016/j.repce.2017.02.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204917300272?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116303869?idApp=UINPBA00004E"
      "url" => "/08702551/0000003600000002/v1_201702090011/S0870255116303869/v1_201702090011/en/main.assets"
    ]
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
    "titulo" => "Neutrophil-to-lymphocyte ratio and ambulatory blood pressure&#58; Exploring the link between inflammation and hypertension"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "107"
        "paginaFinal" => "109"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Jorge Pol&#243;nia"
        "autores" => array:1 [
          0 => array:4 [
            "nombre" => "Jorge"
            "apellidos" => "Pol&#243;nia"
            "email" => array:1 [
              0 => "jjpolonia&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Departamento de Medicina e Cintesis&#44; Faculdade de Medicina da Universidade do Porto&#44; Porto&#44; Portugal"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidade Hipertens&#227;o e Risco Cardiovascular do Hospital Pedro Hispano&#44; Matosinhos&#44; Portugal"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Rela&#231;&#227;o neutr&#243;filos&#47;linf&#243;citos e press&#227;o arterial ambulat&#243;ria&#46; Explorando a rela&#231;&#227;o entre inflama&#231;&#227;o e hipertens&#227;o"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In the last decade a strong and definitive link has been established between inflammation and cardiovascular disease&#46; Inflammation occurs in the vasculature as a response to several types of injury&#46; Various risk factors&#44; including hypertension&#44; diabetes&#44; and smoking&#44; together with oxidized low-density lipoprotein cholesterol&#44; trigger a chronic inflammatory reaction&#44; the result of which is a vulnerable plaque&#44; prone to rupture and thrombosis&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">1</span></a> Epidemiological and clinical studies have consistently shown links between markers of inflammation and risk of future cardiovascular events&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">1</span></a> Activation of macrophages&#44; T lymphocytes&#44; and smooth muscle cells leads to the release of additional mediators&#44; including adhesion molecules&#44; cytokines&#44; chemokines&#44; and growth factors&#44; all of which play important roles in atherogenesis&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">2</span></a> Inflammation plays a role in all stages of atherothrombosis&#44; the underlying cause of approximately 80&#37; of all sudden cardiac deaths&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The study by &#199;imen et al&#46; published in this issue of the <span class="elsevierStyleItalic">Journal</span><a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">4</span></a> examines the relationship between 24-hour ambulatory blood pressure &#40;BP&#41; and a systemic inflammation marker&#44; the neutrophil-to-lymphocyte ratio &#40;NLR&#41;&#46; The authors claim to have shown for the first time that an increased NLR is independently associated with the severity of hypertension &#40;HTN&#41; in patients with untreated essential HTN&#46; NLR is considered a marker of inflammatory status<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">5</span></a> and has been shown to predict risk of coronary disease&#44;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">6</span></a> heart failure<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">7</span></a> and stroke&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">8</span></a> and has been associated with resistant hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">9</span></a> Since HTN is a significant risk factor in inflammatory conditions such as atherosclerosis<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">5</span></a> and inflammatory molecules such as C-reactive protein &#40;CRP&#41;&#44; vascular and intercellular adhesion molecules&#44; monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1 are increased in HTN&#44;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">10&#44;11</span></a> the finding of a proportional increase of NLR with higher severity of HTN fits with the hypothesis of the inflammatory nature of hypertensive disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">12&#8211;14</span></a> Because inflammation may have a role in the pathogenesis and progression of hypertension&#44;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">10&#44;11</span></a> the authors speculate that an increase in this inflammatory marker &#40;which can be easily measured in clinical practice&#41; may help to predict HTN severity and to guide therapy in hypertensive patients&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Other indices derived from blood count parameters have also been identified as inflammatory markers&#44; including red cell distribution width &#40;RDW&#41;&#44; mean platelet volume &#40;MPV&#41; and platelet-to-lymphocyte ratio &#40;PLR&#41;&#44; and some have been associated with different degrees of hypertension severity&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">15&#8211;17</span></a> Some authors have shown that patients with non-dipper hypertension have higher NLR and PLR than those with dipper hypertension&#44; although only PLR &#40;not NLR&#41; was found to be an independent predictor of non-dipper status&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">18</span></a> The most striking aspect of the present study is that HTN was defined on the basis of 24-hour ambulatory BP measurement&#44; in contrast to other authors who used only the less accurate office BP and failed to find any difference in NLR between normotensives and hypertensives&#46; In this study&#44; log NLR values were found to be weakly but positively correlated with 24-hour systolic blood pressure &#40;SBP&#41;&#44; diastolic blood pressure &#40;DBP&#41;&#44; SBP load and DBP load&#44; while in multivariate analysis&#44; log NLR had an independent association with 24-hour BP and 24-hour BP load&#46; However&#44; one of the major limitations of this type of cross-sectional study lies in the general difficulty of proving causal relationships between variables merely because they appear to be associated in proportion&#46; It is always possible that the relationship between these variables is not direct but rather an epiphenomenon&#46; While not questioning the merit or the novelty of the present study&#44; it would have been of considerable interest to determine whether other inflammatory markers which can be easily measured in clinical practice&#44; such as CRP&#44; RDW&#44; MPV&#44; PLR and leukocyte activation markers&#44; were also seen to be associated with ambulatory HTN&#44; which could thereby have confirmed the coherence&#44; correspondence and validity of the observed data in this population&#46; Also in this context it would have been useful to calculate a receiver operating characteristic curve of the diagnostic value of NLR for HTN&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">There is however another finding in this study that deserves some comment&#46; In the interquartile analysis of the NLR distribution&#44; the authors found a relationship between NLR&#44; firstly predominantly with daytime and 24-hour BP values and daytime BP load but not with nighttime BP values&#44; and secondly predominantly with DBP but much less with DBP&#46; This is quite atypical&#46; In several studies<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">19&#8211;24</span></a> nighttime SBP and SBP vs&#46; DBP have been clearly shown to be the strongest independent predictors of cardiovascular events and prognosis among the different indices of BP measurement&#46; We may ask why the relationships established in the present study with NLR were not mainly seen with the BP indices that are better determinants of cardiovascular risk &#40;nighttime and systolic BP&#41; but rather with daytime BP and with others with inferior reproducibility and lower predictive value &#40;BP load and diastolic BP&#41;&#46; One possible speculative explanation for this atypical finding may be the existence of a circadian rhythm of inflammatory immune responses&#44; with day-to-day and day-to-night fluctuations in immune responses to stress&#46; A number of studies have suggested that sleep disorders such as sleep loss&#44; narcolepsy&#44; and sleep apnea are associated with elevated inflammatory markers such as interleukin 6&#44; tumor necrosis factor-alpha&#44; CRP&#44; and white blood cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">25&#8211;27</span></a> For example it has been shown<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">28</span></a> that at the molecular level&#44; &#62;8&#37; of the macrophage transcriptome oscillates in a circadian fashion&#44; including many important regulators for pathogen recognition and cytokine secretion&#46; In addition&#44; time-of-day-dependent fluctuations in the number of neutrophils are not always in line with those of lymphocytes<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">29</span></a> and changes in NLR may be different during day and night&#46; We do not know whether a different NLR measured in blood samples collected at night rather than in the morning could indicate a closer relationship between NLR and nighttime BP values&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A systematic search for inflammatory markers that could enable early detection of the presence of hypertension and its complications in a simple routine blood count is a fascinating challenge&#46; The study by &#199;imen et al&#46; is within this context&#46; However&#44; further research is needed to precisely determine the scientific robustness of the diagnostic and prognostic value of the association between NLR and HTN at the various stages of the evolution of the disease&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:29 [
            0 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation as a cardiovascular risk factor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;T&#46; Willerson"
                            1 => "P&#46;M&#46; Ridker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR.0000129535.04194.38"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2004"
                        "volumen" => "109"
                        "paginaInicial" => "II2"
                        "paginaFinal" => "II10"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15173056"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Novel inflammatory markers of coronary risk&#58; theory versus practice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Libby"
                            1 => "P&#46;M&#46; Ridker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1999"
                        "volumen" => "100"
                        "paginaInicial" => "1148"
                        "paginaFinal" => "1150"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10484532"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prospective study of C-reactive protein&#44; homocysteine&#44; and plasma lipid levels as predictors of sudden cardiac death"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;M&#46; Albert"
                            1 => "J&#46; Ma"
                            2 => "N&#46; Rifai"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2002"
                        "volumen" => "105"
                        "paginaInicial" => "2595"
                        "paginaFinal" => "2599"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12045163"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship between 24-hour ambulatory blood pressure load and neutrophil to lymphocyte ratio"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46; &#199;imen"
                            1 => "H&#46; Sunman"
                            2 => "T&#46; Han Efe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Port Cardiol"
                        "fecha" => "2017"
                        "volumen" => "36"
                        "paginaInicial" => "97"
                        "paginaFinal" => "105"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "F&#46; Imtiaz"
                            1 => "K&#46; Shafique"
                            2 => "S&#46;S&#46; Mirza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Int Archiv Med"
                        "fecha" => "2012"
                        "volumen" => "5"
                        "paginaInicial" => "2"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil-to-lymphocyte ratio predicts hemodynamic significance of coronary artery stenosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Akyel"
                            1 => "C&#46; Yayla"
                            2 => "M&#46; Erat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5152/akd.2015.5909"
                      "Revista" => array:6 [
                        "tituloSerie" => "Anatol J Cardiol"
                        "fecha" => "2015"
                        "volumen" => "15"
                        "paginaInicial" => "1002"
                        "paginaFinal" => "1007"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25880055"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usefulness of neutrophil-to-lymphocyte ratio in risk stratification of patients with advanced heart failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "V&#46;A&#46; Benites-Zapata"
                            1 => "A&#46;V&#46; Hernandez"
                            2 => "V&#46; Nagarajan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2014.10.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2015"
                        "volumen" => "115"
                        "paginaInicial" => "57"
                        "paginaFinal" => "61"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25456873"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is elevated neutrophil-to-lymphocyte ratio a predictor of stroke in patients with intermediate carotid artery stenosis&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46; Koklu"
                            1 => "I&#46;O&#46; Yuksel"
                            2 => "S&#46; Arslan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jstrokecerebrovasdis.2015.10.031"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Stroke Cerebrovasc Dis"
                        "fecha" => "2016"
                        "volumen" => "25"
                        "paginaInicial" => "578"
                        "paginaFinal" => "584"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26706445"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased neutrophil to lymphocyte ratio in patients with resistant hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46; Belen"
                            1 => "A&#46; Sungur"
                            2 => "M&#46;A&#46; Sungur"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Hypertens &#40;Greenwich&#41;"
                        "fecha" => "2015"
                        "volumen" => "17"
                        "paginaInicial" => "532"
                        "paginaFinal" => "537"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Cottone"
                            1 => "G&#46; Mule"
                            2 => "E&#46; Nardi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjhyper.2005.09.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hypertens"
                        "fecha" => "2006"
                        "volumen" => "19"
                        "paginaInicial" => "313"
                        "paginaFinal" => "318"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16500520"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abnormalities of vascular function in resistant hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; de La Sierra"
                            1 => "M&#46; Larrousse"
                            2 => "A&#46; Oliveras"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/08037051.2011.622983"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood Press"
                        "fecha" => "2012"
                        "volumen" => "21"
                        "paginaInicial" => "104"
                        "paginaFinal" => "109"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22017418"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Markers of inflammation&#44; endothelial activation&#44; and arterial stiffness in hypertensive heart disease and the effects of treatment&#58; results from the SILVHIA study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Jekell"
                            1 => "K&#46; Malmqvist"
                            2 => "N&#46;H&#46; Wallen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/FJC.0000000000000017"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cardiovasc Pharmacol"
                        "fecha" => "2013"
                        "volumen" => "62"
                        "paginaInicial" => "559"
                        "paginaFinal" => "566"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24084214"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IL-1beta and IL-18&#58; inflammatory markers or mediators of hypertension&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;M&#46; Krishnan"
                            1 => "C&#46;G&#46; Sobey"
                            2 => "E&#46; Latz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bph.12876"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Pharmacol"
                        "fecha" => "2014"
                        "volumen" => "171"
                        "paginaInicial" => "5589"
                        "paginaFinal" => "5602"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25117218"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation in hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Savoia"
                            1 => "E&#46;L&#46; Schiffrin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.mnh.0000203189.57513.76"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Nephrol Hypertens"
                        "fecha" => "2006"
                        "volumen" => "15"
                        "paginaInicial" => "152"
                        "paginaFinal" => "158"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16481882"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mean platelet volume in patients with dipper and non-dipper hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Ordu"
                            1 => "H&#46; Ozhan"
                            2 => "O&#46; Caglar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/08037050903416402"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood Press"
                        "fecha" => "2010"
                        "volumen" => "19"
                        "paginaInicial" => "26"
                        "paginaFinal" => "30"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19929284"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Red cell distribution width and inflammation in patients with non-dipper hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "F&#46; Ozcan"
                            1 => "O&#46; Turak"
                            2 => "A&#46; Durak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/08037051.2012.707336"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood Press"
                        "fecha" => "2013"
                        "volumen" => "22"
                        "paginaInicial" => "80"
                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22835009"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "U&#46;U&#46; Tamhane"
                            1 => "S&#46; Aneja"
                            2 => "D&#46; Montgomery"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2008.05.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2008"
                        "volumen" => "102"
                        "paginaInicial" => "653"
                        "paginaFinal" => "657"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18773982"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Sunbul"
                            1 => "F&#46; Gerin"
                            2 => "E&#46; Durmus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/10641963.2013.804547"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Hypertens"
                        "fecha" => "2014"
                        "volumen" => "36"
                        "paginaInicial" => "217"
                        "paginaFinal" => "221"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23786430"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Value of ambulatory arterial pressure monitoring in the prediction of target-organ damage and cardiovascular events"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;C&#46; Hermida"
                            1 => "D&#46;E&#46; Ayala"
                            2 => "C&#46; Calvo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2002"
                        "volumen" => "22"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "59"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12014304"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "discussion 40"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic impact from clinic&#44; daytime&#44; and night-time systolic blood pressure in nine cohorts of 13&#44;844 patients with hypertension"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "ABC-H Investigators"
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46;C&#46; Roush"
                            1 => "R&#46;H&#46; Fagard"
                            2 => "G&#46;F&#46; Salles"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/HJH.0000000000000355"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2014"
                        "volumen" => "32"
                        "paginaInicial" => "2332"
                        "paginaFinal" => "2340"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25333682"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stroke prognosis and abnormal nocturnal blood pressure falls in older hypertensives"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Kario"
                            1 => "T&#46;G&#46; Pickering"
                            2 => "T&#46; Matsuo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2001"
                        "volumen" => "38"
                        "paginaInicial" => "852"
                        "paginaFinal" => "857"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11641298"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular prognostic value of ambulatory blood pressure monitoring in a Portuguese hypertensive population followed up for 8&#46;2 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Mesquita-Bastos"
                            1 => "S&#46; Bertoquini"
                            2 => "J&#46; Polonia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MBP.0b013e32833c8b08"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood Press Monit"
                        "fecha" => "2010"
                        "volumen" => "15"
                        "paginaInicial" => "240"
                        "paginaFinal" => "246"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20616705"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic effect of the nocturnal blood pressure fall in hypertensive patients&#58; the Ambulatory Blood Pressure Collaboration in Patients With Hypertension &#40;ABC-H&#41; meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46;F&#46; Salles"
                            1 => "G&#46; Reboldi"
                            2 => "R&#46;H&#46; Fagard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/HYPERTENSIONAHA.115.06981"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2016"
                        "volumen" => "67"
                        "paginaInicial" => "693"
                        "paginaFinal" => "700"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26902495"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ambulatory pulse pressure as predictor of outcome in older patients with systolic hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;A&#46; Staessen"
                            1 => "L&#46; Thijs"
                            2 => "E&#46;T&#46; O&#8217;Brien"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hypertens"
                        "fecha" => "2002"
                        "volumen" => "15"
                        "paginaInicial" => "835"
                        "paginaFinal" => "843"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12372669"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased plasma level of tumor necrosis factor alpha in patients with narcolepsy in Taiwan"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46;H&#46; Chen"
                            1 => "Y&#46;S&#46; Huang"
                            2 => "C&#46;H&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.sleep.2013.04.030"
                      "Revista" => array:6 [
                        "tituloSerie" => "Sleep Med"
                        "fecha" => "2013"
                        "volumen" => "14"
                        "paginaInicial" => "1272"
                        "paginaFinal" => "1276"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24157100"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;R&#46; Irwin"
                            1 => "M&#46; Wang"
                            2 => "C&#46;O&#46; Campomayor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archinte.166.16.1756"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "2006"
                        "volumen" => "166"
                        "paginaInicial" => "1756"
                        "paginaFinal" => "1762"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16983055"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin-6 and cortisol levels&#58; physiologic and therapeutic implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;N&#46; Vgontzas"
                            1 => "M&#46; Zoumakis"
                            2 => "E&#46;O&#46; Bixler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2002-021176"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2003"
                        "volumen" => "88"
                        "paginaInicial" => "2087"
                        "paginaFinal" => "2095"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12727959"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A circadian clock in macrophages controls inflammatory immune responses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Keller"
                            1 => "J&#46; Mazuch"
                            2 => "U&#46; Abraham"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1073/pnas.0906361106"
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci U S A"
                        "fecha" => "2009"
                        "volumen" => "106"
                        "paginaInicial" => "21407"
                        "paginaFinal" => "21412"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19955445"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Circadian rhythm of leucocytes and lymphocytes subsets and its possible correlation with the function of the autonomic nervous system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Suzuki"
                            1 => "S&#46; Toyabe"
                            2 => "T&#46; Moroda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Immunol"
                        "fecha" => "1997"
                        "volumen" => "110"
                        "paginaInicial" => "500"
                        "paginaFinal" => "508"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9409657"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/08702551/0000003600000002/v1_201702090011/S0870255116303894/v1_201702090011/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "29261"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Artigos Originais"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08702551/0000003600000002/v1_201702090011/S0870255116303894/v1_201702090011/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116303894?idApp=UINPBA00004E"
]
Informação do artigo
ISSN: 08702551
Idioma original: Inglês
Dados atualizados diariamente
Ano/Mês Html Pdf Total
2024 Novembro 10 3 13
2024 Outubro 55 29 84
2024 Setembro 54 29 83
2024 Agosto 76 37 113
2024 Julho 54 40 94
2024 Junho 50 27 77
2024 Maio 60 22 82
2024 Abril 66 31 97
2024 Maro 39 17 56
2024 Fevereiro 50 32 82
2024 Janeiro 40 34 74
2023 Dezembro 38 26 64
2023 Novembro 45 29 74
2023 Outubro 28 19 47
2023 Setembro 39 26 65
2023 Agosto 38 21 59
2023 Julho 37 11 48
2023 Junho 42 15 57
2023 Maio 45 40 85
2023 Abril 33 13 46
2023 Maro 37 24 61
2023 Fevereiro 38 24 62
2023 Janeiro 28 18 46
2022 Dezembro 46 20 66
2022 Novembro 75 25 100
2022 Outubro 30 26 56
2022 Setembro 44 23 67
2022 Agosto 39 34 73
2022 Julho 45 32 77
2022 Junho 34 19 53
2022 Maio 36 34 70
2022 Abril 33 27 60
2022 Maro 22 36 58
2022 Fevereiro 25 30 55
2022 Janeiro 35 24 59
2021 Dezembro 22 30 52
2021 Novembro 27 33 60
2021 Outubro 52 55 107
2021 Setembro 40 33 73
2021 Agosto 57 30 87
2021 Julho 42 28 70
2021 Junho 50 29 79
2021 Maio 45 38 83
2021 Abril 76 45 121
2021 Maro 76 28 104
2021 Fevereiro 100 20 120
2021 Janeiro 58 18 76
2020 Dezembro 51 17 68
2020 Novembro 43 17 60
2020 Outubro 23 18 41
2020 Setembro 62 17 79
2020 Agosto 33 8 41
2020 Julho 63 17 80
2020 Junho 44 15 59
2020 Maio 63 18 81
2020 Abril 49 11 60
2020 Maro 58 11 69
2020 Fevereiro 208 16 224
2020 Janeiro 35 11 46
2019 Dezembro 38 10 48
2019 Novembro 52 13 65
2019 Outubro 51 4 55
2019 Setembro 35 11 46
2019 Agosto 44 12 56
2019 Julho 40 17 57
2019 Junho 20 15 35
2019 Maio 43 6 49
2019 Abril 35 16 51
2019 Maro 64 8 72
2019 Fevereiro 78 15 93
2019 Janeiro 35 5 40
2018 Dezembro 56 11 67
2018 Novembro 67 12 79
2018 Outubro 131 24 155
2018 Setembro 39 13 52
2018 Agosto 30 8 38
2018 Julho 15 8 23
2018 Junho 44 3 47
2018 Maio 21 10 31
2018 Abril 65 3 68
2018 Maro 50 15 65
2018 Fevereiro 23 8 31
2018 Janeiro 29 6 35
2017 Dezembro 44 17 61
2017 Novembro 58 12 70
2017 Outubro 29 16 45
2017 Setembro 34 10 44
2017 Agosto 41 17 58
2017 Julho 29 7 36
2017 Junho 42 20 62
2017 Maio 58 24 82
2017 Abril 28 12 40
2017 Maro 43 21 64
2017 Fevereiro 59 46 105
Mostrar tudo

Siga este link para acessar o texto completo do artigo

Idiomas
Revista Portuguesa de Cardiologia
en pt

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

Ao assinalar que é «Profissional de Saúde», declara conhecer e aceitar que a responsável pelo tratamento dos dados pessoais dos utilizadores da página de internet da Revista Portuguesa de Cardiologia (RPC), é esta entidade, com sede no Campo Grande, n.º 28, 13.º, 1700-093 Lisboa, com os telefones 217 970 685 e 217 817 630, fax 217 931 095 e com o endereço de correio eletrónico revista@spc.pt. Declaro para todos os fins, que assumo inteira responsabilidade pela veracidade e exatidão da afirmação aqui fornecida.