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array:25 [ "pii" => "S0870255116303845" "issn" => "08702551" "doi" => "10.1016/j.repc.2016.04.015" "estado" => "S300" "fechaPublicacion" => "2017-02-01" "aid" => "932" "copyright" => "Sociedade Portuguesa de Cardiologia" "copyrightAnyo" => "2016" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Rev Port Cardiol. 2017;36:145.e1-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2368 "formatos" => array:3 [ "EPUB" => 162 "HTML" => 1781 "PDF" => 425 ] ] "Traduccion" => array:1 [ "en" => array:20 [ "pii" => "S2174204917300375" "issn" => "21742049" "doi" => "10.1016/j.repce.2017.02.013" "estado" => "S300" "fechaPublicacion" => "2017-02-01" "aid" => "932" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Rev Port Cardiol. 2017;36:145.e1-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1819 "formatos" => array:3 [ "EPUB" => 140 "HTML" => 1388 "PDF" => 291 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Left ventricular rigid body rotation in a diffuse large B-cell lymphoma patient with cardiac involvement: A case from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "145.e1" "paginaFinal" => "145.e5" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "«Rotação corporal rígida» ventricular esquerda num doente com linfoma difuso de células B e envolvimento cardíaco. Um caso de ecocardiografia tridimensional de <span class="elsevierStyleItalic">speckle-tracking</span> – estudo <span class="elsevierStyleItalic">MAGYAR-Path</span>" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2063 "Ancho" => 2500 "Tamanyo" => 488148 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Positron emission tomography/computed tomography image of the patient with diffuse large B-cell lymphoma showing dorsal focal <span class="elsevierStyleSup">18</span>F-fluorodeoxyglucose accumulation in the myocardium (white arrows).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Dóra Földeák, Anita Kalapos, Péter Domsik, Mária Sinkó, Nóra Szeleczki, Enikő Bagdi, László Krenács, Tamás Forster, Zita Borbényi, Attila Nemes" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Dóra" "apellidos" => "Földeák" ] 1 => array:2 [ "nombre" => "Anita" "apellidos" => "Kalapos" ] 2 => array:2 [ "nombre" => "Péter" "apellidos" => "Domsik" ] 3 => array:2 [ "nombre" => "Mária" "apellidos" => "Sinkó" ] 4 => array:2 [ "nombre" => "Nóra" "apellidos" => "Szeleczki" ] 5 => array:2 [ "nombre" => "Enikő" "apellidos" => "Bagdi" ] 6 => array:2 [ "nombre" => "László" "apellidos" => "Krenács" ] 7 => array:2 [ "nombre" => "Tamás" "apellidos" => "Forster" ] 8 => array:2 [ "nombre" => "Zita" "apellidos" => "Borbényi" ] 9 => array:2 [ "nombre" => "Attila" "apellidos" => "Nemes" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0870255116303845" "doi" => "10.1016/j.repc.2016.04.015" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116303845?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204917300375?idApp=UINPBA00004E" "url" => "/21742049/0000003600000002/v1_201702240018/S2174204917300375/v1_201702240018/en/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S0870255116304280" "issn" => "08702551" "doi" => "10.1016/j.repc.2016.07.011" "estado" => "S300" "fechaPublicacion" => "2017-02-01" "aid" => "941" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Rev Port Cardiol. 2017;36:147-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2124 "formatos" => array:3 [ "EPUB" => 169 "HTML" => 1546 "PDF" => 409 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Image in Cardiology</span>" "titulo" => "Mid-aortic syndrome in a patient with neurofibromatosis type 1" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "147" "paginaFinal" => "148" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Síndrome da aorta média em paciente com neurofibromatose tipo 1" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1000 "Ancho" => 680 "Tamanyo" => 97247 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Sagittal plane reformation showing severe narrowing of the aorta (arrow) and a saccular aneurysm (star) at the level of the renal arteries. 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para retardar a ejaculação" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1133 "Ancho" => 2360 "Tamanyo" => 655248 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Ventricular tachycardia.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Belén Díaz-Antón, Guillermo Alonso-Deniz, Jose Luis Perez-Vela, Javier Molina-Martín de Nicolás, Belen Rubio-Alonso, Alfonso Jurado-Román, Ana Miguel-Gutierrez, Roberto Martin-Asenjo" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Belén" "apellidos" => "Díaz-Antón" ] 1 => array:2 [ "nombre" => 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class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Anita" "apellidos" => "Kalapos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Péter" "apellidos" => "Domsik" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Mária" "apellidos" => "Sinkó" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "Nóra" "apellidos" => "Szeleczki" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "Enikő" "apellidos" => "Bagdi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 6 => array:3 [ "nombre" => "László" "apellidos" => "Krenács" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 7 => array:3 [ "nombre" => "Tamás" "apellidos" => "Forster" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 8 => array:3 [ "nombre" => "Zita" "apellidos" => "Borbényi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 9 => array:4 [ "nombre" => "Attila" "apellidos" => "Nemes" "email" => array:1 [ 0 => "nemes.attila@med.u-szeged.hu" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Division of Haematology, 2nd Department of Medicine and Cardiology Center, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "2nd Department of Medicine and Cardiology Center, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "PET/CT Centre, Bács-Kiskun County Hospital, Kecskemét, Hungary" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Laboratory of Tumor Pathology and Molecular Diagnostics, Szeged, Hungary" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "«Rotação corporal rígida» ventricular esquerda num doente com linfoma difuso de células B e envolvimento cardíaco. Um caso de ecocardiografia tridimensional de <span class="elsevierStyleItalic">speckle-tracking</span> – estudo <span class="elsevierStyleItalic">MAGYAR-Path</span>" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 869 "Ancho" => 1500 "Tamanyo" => 205310 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Apical 4-chamber (A) and 2-chamber (B) views and short-axis views (C3, C5, C7) at different levels of the left ventricle (LV) extracted from the three-dimensional (3D) echocardiographic dataset in the patient with diffuse large B-cell lymphoma. The 3D model of the left ventricle and calculated LV volumetric and functional characteristics are also presented together with LV rotational (D) and strain (E) parameters. Apical (white arrow), midventricular and basal (dashed arrow) LV rotations were demonstrated to be in the same counterclockwise direction, confirming the near absence of LV twist (rigid body rotation). Some segmental LV strains were also found to be reduced. EDV: end-diastolic volume; EF: ejection fraction; ESV: end-systolic volume; LV: left ventricular.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Secondary myocardial involvement by diffuse large B-cell lymphoma is an uncommon occurrence. Primary mediastinal B-cell lymphoma is an uncommon aggressive subset of diffuse large B-cell lymphoma.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">1</span></a> It frequently spreads locally from the thymus into the pleura and the pericardium, but rarely invades directly through the heart.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">1</span></a> It occasionally manifests as an intracardiac mass, often diagnosed on autopsy, and 90% are clinically silent.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">2,3</span></a> This type of lymphoma is more prevalent in women, mainly in the third and fourth decades of life, and represents 2-3% of non-Hodgkin's lymphomas.<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">1,4</span></a> It usually presents with systemic symptoms (weight loss, fever, night sweats), shortness of breath, chest discomfort, and palpable lymph nodes.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Left ventricular (LV) twist is considered an essential part of LV function.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">5</span></a> In normal circumstances LV twist results from the movement of two orthogonally oriented muscular bands of a helical myocardial structure with consequent clockwise rotation of the LV base and counterclockwise rotation of the LV apex.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">6</span></a> This twisting deformation plays a fundamental part in the mechanical efficiency of the heart, resulting in 60% ejection fraction (EF) with only 15% fiber shortening.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">7</span></a> Recent developments in speckle-tracking echocardiography (STE) provide an opportunity to make accurate, reproducible and bedside assessments of LV twist in daily clinical practice.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">5</span></a> Three-dimensional (3D) speckle-tracking echocardiography (3DSTE) has been found to be feasible for non-invasive 3D quantification of LV wall motion and rotational mechanics.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a> The present report aimed to assess LV twisting motion in a patient with diffuse large B-cell lymphoma with positron emission tomography (PET)/computer tomography (CT)-proven cardiac involvement by 3DSTE.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0015" class="elsevierStylePara elsevierViewall">A 52-year-old female patient was admitted to the hospital due to shortness of breath. As a part of her examination, chest and abdominal CT was performed, on which several pathological lymph nodes could be observed in the mediastinal and abdominal regions together with pleural and pericardial effusions. In the upper third of the mediastinum, a soft tissue mass was detected, from which a biopsy was taken. Histology confirmed a CD20-positive primary mediastinal lymphoma, which is considered a subset of diffuse large B-cell lymphoma and is an uncommon clinical and pathological entity in the World Health Organization classification of lymphomas.<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">1,4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Chemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine and methylprednisolone (R-CHOP) was started according to international recommendations.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">9</span></a> R-CHOP includes rituximab, an anti-CD20 antibody, an essential part of the treatment. Following four cycles every 21 days, chest CT was repeated, which detected small lymph nodes in the hilar regions and in the right paratracheal area. Thus, according to the CT scan, the treatment resulted in partial response.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Altogether, the patient received eight cycles of such chemotherapy. After completion of the treatment, a combined low-dose plain CT and <span class="elsevierStyleSup">18</span>F-fluorodeoxyglucose (FDG)-PET examination was performed using a Siemens Biograph 6 PET/CT scanner (Siemens Healthcare, Erlangen, Germany). PET/CT showed activity in the mediastinal region and a single 2 cm×5 cm active lymph node in the left hilar region. Regarding disease activity, the patient received 39.6 Gy of radiation to the mediastinal area. Three weeks later, palpable masses could be detected during physical examination in the left and right lower limb region. Biopsy was performed of the left-side mass, showing extranodal manifestation of the disease. The patient went through two cycles of salvage chemotherapy (rituximab, cisplatin, cytosine arabinoside and dexamethasone, R-DHAP) and stem cell collection was also performed. Following treatment, the skin manifestations disappeared.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Autologous stem cell transplantation was planned as the next treatment option in the event of complete remission. To confirm the response, combined low-dose plain CT and <span class="elsevierStyleSup">18</span>F FDG-PET examination was repeated, which showed progression in the skin and the lymph node regions. Moreover, pericardial effusion (maximum thickness 22 mm) and cardiac involvement in the dorsal region (multiple active fields with the maximum standardized uptake value of 33.4) were also confirmed, indicating lymphoma manifestation in the heart (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">No arrhythmias were detected, but the patient had symptoms of hypotonia and chest pain, as well as anemia (hemoglobin: 94 g/l) and increased lactate dehydrogenase (1824 U/l) and troponin T (0.261 μg/l) levels, with normal creatinine kinase (62 U/l). Urgent coronary angiography showed normal epicardial coronary arteries. Neurological symptoms including dizziness, blurred vision and altered mental status indicated central nervous system manifestation of the lymphoma. Plain non-enhanced cranial CT was performed, with a negative result. Lumbar puncture was also performed and showed no signs of lymphoma involvement or infection. A new course of chemotherapy was started with rituximab and the BFM protocol (first day: vincristine 2 mg, methotrexate 3 g/m<span class="elsevierStyleSup">2</span>; from day 1-5: ifosfamide 800 mg/m<span class="elsevierStyleSup">2</span>; day 4-5: cytosine arabinoside 2×150 mg/m<span class="elsevierStyleSup">2</span> and dexamethasone 10 mg/m<span class="elsevierStyleSup">2</span>) for five days. Clinically, the patient is stable, but requires more courses of chemotherapy.</p><p id="par0040" class="elsevierStylePara elsevierViewall">As a part of her assessment, routine two-dimensional Doppler echocardiography and 3DSTE were performed using Toshiba Artida™ ultrasound equipment with PST-30SBP phased-array and PST-25SX matrix phased-array transducers (Toshiba Medical Systems, Tokyo, Japan). Data acquisition and evaluation of echocardiographic studies followed recent guidelines and practices.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a> Echocardiographic examination found normal atrial and ventricular dimensions and 50% EF, with no wall motion abnormalities and with grade I diastolic dysfunction. Color Doppler echocardiography confirmed grade 1 mitral regurgitation. Pericardial effusion was detected, 7-11 mm in size next to the posterior, lateral and inferior walls and 10-12 mm around the right apical region. During 3DSTE with a frame rate of 27 volumes per second, reduction in some segmental radial, longitudinal, circumferential, area and 3D LV strains were found (<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>). Apical and basal LV rotations were found to be in the same counterclockwise direction, confirming near absence of LV twist – so-called rigid body rotation (RBR).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">The patient was enrolled in the MAGYAR-Path study (Motion Analysis of the heart and Great vessels bY three-dimensionAl speckle-tRacking echocardiography in Pathological cases) and had provided informed consent. The study protocol conformed to the ethical guidelines of the 1975 Declaration of Helsinki and was approved by the institution's human research committee.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">Primary cardiac tumors are extremely rare, with a prevalence of 0.001-0.28%.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">2,3</span></a> The incidence of secondary cardiac tumors varies from 2-18.3%.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">2,10</span></a> Among secondary tumors, cardiac involvement by lymphoma is infrequent, but in an autopsy study of malignant lymphoma, cardiac metastasis was found in 16% of cases.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">2,11</span></a> Less than 5% of cardiac tumors are primary, and of these, only 1.3% are primary cardiac lymphoma.<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">12–15</span></a> Its incidence is higher in immunocompromised hosts, and B-cell lymphoma is the most common type.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">12</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Despite involvement of myocardial tissue, cardiac symptoms may be absent or non-specific. Case reports seem to indicate that the heart is more often involved in non-Hodgkin's lymphoma, but pericardial manifestation is more common in Hodgkin's disease.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">2,13</span></a> Cardiac lymphomas are usually small and multiple, sometimes focal or diffuse, but tumor infiltrations of the pericardium, myocardium or endocardium have also been observed. The right side of the heart has been found to be more frequently involved than the left side.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">To the best of the authors’ knowledge this is the first time alterations in LV rotational mechanics have been demonstrated in a patient with PET/CT-proven cardiac lymphoma. The left ventricle consists of a 3D helical structure which is responsible for cyclic twisting deformation in systole, resulting from clockwise rotation of the LV base and counterclockwise rotation of the LV apex.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">6</span></a> It is known that aging appeared to be related to an increase in LV twist,<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">16</span></a> and in specific pathological circumstances LV rotation and twist can be altered. In particular, in recent studies LV basal rotation was found to be moderately increased in hypertrophic cardiomyopathy, but was reduced in non-ischemic dilated cardiomyopathy due to reduction in both apical and basal LV rotations.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">5</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">In the present case, both apical and basal LV regions moved in the same counterclockwise direction to a similar extent (a difference of about 6°), confirming the near absence of LV twist (RBR). RBR has previously only been demonstrated in a limited number of disorders, including cardiomyopathies (peripartum,<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">17</span></a> hypertensive,<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">18</span></a> dilated with reduced EF<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">19</span></a> and noncompaction<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">20</span></a>), infiltrative disorders (amyloidosis)<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">21</span></a> and congenital heart disease (univentricular heart<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">22</span></a> and hypoplastic right heart syndrome<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">23</span></a>). The underlying mechanism is unknown, but the findings presented could be explained by infiltration of the myocardium by lymphoma tissue, as confirmed in some areas by PET/CT. As the basic principle of PET is the increased glycolysis characteristic of tumors, which consume more glucose than normal tissue, the damage caused by chemotherapy shows up as a negative change on PET. Thus the PET/CT result and the 3DSTE result are identical, which proves that in this case the lesions are due to the lymphoma and not to cardiotoxic effects.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Further studies are needed to confirm our findings in larger patient populations focusing on the pathomechanism, clinical relevance and implications of LV RBR and on possible treatment options.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Ethical disclosures</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Protection of human and animal subjects</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors declare that the procedures followed were in accordance with the regulations of the relevant clinical research ethics committee and with those of the Code of Ethics of the World Medical Association (Declaration of Helsinki).</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Confidentiality of data</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Right to privacy and informed consent</span><p id="par0090" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflicts of interest</span><p id="par0095" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres799824" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec798334" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres799823" "titulo" => "Resumo" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec798333" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:3 [ "identificador" => "sec0020" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0030" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0035" "titulo" => "Right to privacy and informed consent" ] ] ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflicts of interest" ] 9 => array:2 [ "identificador" => "xack267889" "titulo" => "Acknowledgments" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-01-05" "fechaAceptado" => "2016-04-26" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec798334" "palabras" => array:6 [ 0 => "Three-dimensional" 1 => "Speckle-tracking" 2 => "Echocardiography" 3 => "Lymphoma" 4 => "Rotation" 5 => "Twist" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec798333" "palabras" => array:6 [ 0 => "Tridimensional" 1 => "<span class="elsevierStyleItalic">Speckle-tracking</span>" 2 => "Ecocardiografia" 3 => "Linfoma" 4 => "Rotação" 5 => "Torção" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Secondary myocardial involvement by diffuse large B-cell lymphoma is a rare occurrence. Left ventricular (LV) twist is considered an essential part of LV function. In normal circumstances LV twist results from the movement of two orthogonally oriented muscular bands of a helical myocardial structure with consequent clockwise rotation of the base and counterclockwise rotation of the apex. Three-dimensional (3D) speckle-tracking echocardiography (3DSTE) has been found to be feasible for non-invasive 3D quantification of LV wall motion and rotational mechanics. The present report aimed to assess LV twisting motion in a patient with diffuse large B-cell lymphoma with positron emission tomography/computer tomography-proven cardiac involvement by 3DSTE. During 3DSTE, reduction in some segmental radial, longitudinal, circumferential, area and 3D LV strains were found. Apical and basal LV rotations were found to be in the same counterclockwise direction, confirming near absence of LV twist – so-called rigid body rotation.</p></span>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">O envolvimento do miocárdio secundário ao linfoma difuso de células grandes B é uma ocorrência rara. A torção ventricular esquerda (VE) é considerada uma parte essencial da função VE. Em circunstâncias normais, a torção do VE resulta do movimento de uma estrutura miocárdica helicoidal de duas bandas musculares orientadas ortogonalmente, com a consequente rotação no sentido dos ponteiros do relógio da base do VE e rotação contra os ponteiros do relógio do ápex do VE. A ecocardiografia tridimensional (3D) de <span class="elsevierStyleItalic">speckle-tracking</span> (3DSTE) foi considerada adequada para a quantificação 3D não invasiva da contratilidade segmentar VE e da mecânica de rotação. Este artigo tem como objetivo a avaliação do movimento de torção VE por 3DSTE num doente com linfoma difuso de células grandes B e envolvimento cardíaco comprovado por tomografia de emissão de positrões/tomografia. Por 3DSTE foi verificada uma certa redução do <span class="elsevierStyleItalic">strain</span> radial, longitudinal, circunferencial do VE. A rotação dos segmentos basais e apicais do VE foi semelhante, num mesmo sentido, contra os ponteiros do relógio. Tal conduziu a uma redução marcada da torção do VE – <span class="elsevierStyleItalic">rigid body rotations</span>. Detetaram-se rotações VE apicais e basais no sentido contrário ao dos ponteiros do relógio, confirmando a ausência próxima da torção VE conforme referido «rotação rígida do corpo».</p></span>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1238 "Ancho" => 1500 "Tamanyo" => 230938 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Positron emission tomography/computed tomography image of the patient with diffuse large B-cell lymphoma showing dorsal focal <span class="elsevierStyleSup">18</span>F-fluorodeoxyglucose accumulation in the myocardium (white arrows).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 869 "Ancho" => 1500 "Tamanyo" => 205310 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Apical 4-chamber (A) and 2-chamber (B) views and short-axis views (C3, C5, C7) at different levels of the left ventricle (LV) extracted from the three-dimensional (3D) echocardiographic dataset in the patient with diffuse large B-cell lymphoma. The 3D model of the left ventricle and calculated LV volumetric and functional characteristics are also presented together with LV rotational (D) and strain (E) parameters. Apical (white arrow), midventricular and basal (dashed arrow) LV rotations were demonstrated to be in the same counterclockwise direction, confirming the near absence of LV twist (rigid body rotation). Some segmental LV strains were also found to be reduced. EDV: end-diastolic volume; EF: ejection fraction; ESV: end-systolic volume; LV: left ventricular.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib0120" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Heart of lymphoma: primary mediastinal large B-cell lymphoma with endomyocardial involvement" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E. Rogowitz" 1 => "H.M. Babiker" 2 => "R. 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Ano/Mês | Html | Total | |
---|---|---|---|
2024 Novembro | 6 | 6 | 12 |
2024 Outubro | 47 | 36 | 83 |
2024 Setembro | 49 | 20 | 69 |
2024 Agosto | 46 | 31 | 77 |
2024 Julho | 36 | 30 | 66 |
2024 Junho | 47 | 20 | 67 |
2024 Maio | 52 | 20 | 72 |
2024 Abril | 38 | 29 | 67 |
2024 Maro | 47 | 21 | 68 |
2024 Fevereiro | 47 | 18 | 65 |
2024 Janeiro | 32 | 24 | 56 |
2023 Dezembro | 35 | 17 | 52 |
2023 Novembro | 43 | 45 | 88 |
2023 Outubro | 34 | 19 | 53 |
2023 Setembro | 44 | 26 | 70 |
2023 Agosto | 46 | 18 | 64 |
2023 Julho | 34 | 8 | 42 |
2023 Junho | 34 | 10 | 44 |
2023 Maio | 44 | 32 | 76 |
2023 Abril | 37 | 4 | 41 |
2023 Maro | 40 | 22 | 62 |
2023 Fevereiro | 33 | 23 | 56 |
2023 Janeiro | 22 | 13 | 35 |
2022 Dezembro | 43 | 23 | 66 |
2022 Novembro | 53 | 27 | 80 |
2022 Outubro | 25 | 17 | 42 |
2022 Setembro | 29 | 21 | 50 |
2022 Agosto | 37 | 31 | 68 |
2022 Julho | 34 | 30 | 64 |
2022 Junho | 25 | 20 | 45 |
2022 Maio | 26 | 31 | 57 |
2022 Abril | 36 | 24 | 60 |
2022 Maro | 23 | 33 | 56 |
2022 Fevereiro | 25 | 26 | 51 |
2022 Janeiro | 32 | 21 | 53 |
2021 Dezembro | 22 | 32 | 54 |
2021 Novembro | 37 | 35 | 72 |
2021 Outubro | 101 | 38 | 139 |
2021 Setembro | 38 | 30 | 68 |
2021 Agosto | 47 | 24 | 71 |
2021 Julho | 24 | 18 | 42 |
2021 Junho | 28 | 22 | 50 |
2021 Maio | 39 | 36 | 75 |
2021 Abril | 49 | 50 | 99 |
2021 Maro | 43 | 13 | 56 |
2021 Fevereiro | 51 | 28 | 79 |
2021 Janeiro | 38 | 11 | 49 |
2020 Dezembro | 21 | 18 | 39 |
2020 Novembro | 40 | 18 | 58 |
2020 Outubro | 26 | 12 | 38 |
2020 Setembro | 48 | 6 | 54 |
2020 Agosto | 35 | 7 | 42 |
2020 Julho | 38 | 14 | 52 |
2020 Junho | 51 | 12 | 63 |
2020 Maio | 47 | 4 | 51 |
2020 Abril | 50 | 10 | 60 |
2020 Maro | 37 | 12 | 49 |
2020 Fevereiro | 72 | 36 | 108 |
2020 Janeiro | 32 | 5 | 37 |
2019 Dezembro | 62 | 9 | 71 |
2019 Novembro | 48 | 8 | 56 |
2019 Outubro | 65 | 7 | 72 |
2019 Setembro | 28 | 6 | 34 |
2019 Agosto | 35 | 7 | 42 |
2019 Julho | 38 | 9 | 47 |
2019 Junho | 28 | 5 | 33 |
2019 Maio | 32 | 7 | 39 |
2019 Abril | 36 | 16 | 52 |
2019 Maro | 105 | 11 | 116 |
2019 Fevereiro | 94 | 12 | 106 |
2019 Janeiro | 108 | 4 | 112 |
2018 Dezembro | 84 | 10 | 94 |
2018 Novembro | 88 | 8 | 96 |
2018 Outubro | 113 | 12 | 125 |
2018 Setembro | 29 | 11 | 40 |
2018 Agosto | 28 | 9 | 37 |
2018 Julho | 22 | 6 | 28 |
2018 Junho | 35 | 5 | 40 |
2018 Maio | 24 | 9 | 33 |
2018 Abril | 38 | 6 | 44 |
2018 Maro | 49 | 12 | 61 |
2018 Fevereiro | 30 | 12 | 42 |
2018 Janeiro | 22 | 5 | 27 |
2017 Dezembro | 51 | 15 | 66 |
2017 Novembro | 65 | 10 | 75 |
2017 Outubro | 33 | 12 | 45 |
2017 Setembro | 22 | 10 | 32 |
2017 Agosto | 34 | 16 | 50 |
2017 Julho | 24 | 14 | 38 |
2017 Junho | 31 | 19 | 50 |
2017 Maio | 48 | 21 | 69 |
2017 Abril | 30 | 9 | 39 |
2017 Maro | 45 | 15 | 60 |
2017 Fevereiro | 64 | 43 | 107 |