que se leu este artigo
array:25 [ "pii" => "S0870255116301676" "issn" => "08702551" "doi" => "10.1016/j.repc.2016.04.010" "estado" => "S300" "fechaPublicacion" => "2016-10-01" "aid" => "860" "copyright" => "Sociedade Portuguesa de Cardiologia" "copyrightAnyo" => "2016" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2016;35:525-30" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2661 "formatos" => array:3 [ "EPUB" => 206 "HTML" => 1892 "PDF" => 563 ] ] "Traduccion" => array:1 [ "en" => array:20 [ "pii" => "S2174204916301568" "issn" => "21742049" "doi" => "10.1016/j.repce.2016.04.007" "estado" => "S300" "fechaPublicacion" => "2016-10-01" "aid" => "860" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2016;35:525-30" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2357 "formatos" => array:3 [ "EPUB" => 176 "HTML" => 1678 "PDF" => 503 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Epicardial fat tissue thickness is increased in patients with lichen planus and is linked to inflammation and dyslipidemia" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "525" "paginaFinal" => "530" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Espessura do tecido adiposo epicárdico aumentada em pacientes com líquen plano e relação com inflamação e dislipidemia" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ahmet Goktug Ertem, Mehmet Erdogan, Cemal Koseoglu, Gulsen Akoglu, Elcin Ozdemir, Gamze Koseoglu, Serkan Sivri, Telat Keles, Tahir Durmaz, Akın Aktas, Engin Bozkurt" "autores" => array:11 [ 0 => array:2 [ "nombre" => "Ahmet Goktug" "apellidos" => "Ertem" ] 1 => array:2 [ "nombre" => "Mehmet" "apellidos" => "Erdogan" ] 2 => array:2 [ "nombre" => "Cemal" "apellidos" => "Koseoglu" ] 3 => array:2 [ "nombre" => "Gulsen" "apellidos" => "Akoglu" ] 4 => array:2 [ "nombre" => "Elcin" "apellidos" => "Ozdemir" ] 5 => array:2 [ "nombre" => "Gamze" "apellidos" => "Koseoglu" ] 6 => array:2 [ "nombre" => "Serkan" "apellidos" => "Sivri" ] 7 => array:2 [ "nombre" => "Telat" "apellidos" => "Keles" ] 8 => array:2 [ "nombre" => "Tahir" "apellidos" => "Durmaz" ] 9 => array:2 [ "nombre" => "Akın" "apellidos" => "Aktas" ] 10 => array:2 [ "nombre" => "Engin" "apellidos" => "Bozkurt" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0870255116301676" "doi" => "10.1016/j.repc.2016.04.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116301676?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204916301568?idApp=UINPBA00004E" "url" => "/21742049/0000003500000010/v1_201610140050/S2174204916301568/v1_201610140050/en/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S0870255116301706" "issn" => "08702551" "doi" => "10.1016/j.repc.2016.06.005" "estado" => "S300" "fechaPublicacion" => "2016-10-01" "aid" => "863" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "ssu" "cita" => "Rev Port Cardiol. 2016;35:531-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3178 "formatos" => array:3 [ "EPUB" => 185 "HTML" => 2413 "PDF" => 580 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "Renal denervation in the treatment of resistant hypertension: Dead, alive or surviving?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "531" "paginaFinal" => "538" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Desnervação renal no tratamento da hipertensão arterial resistente: morta, viva ou sobrevivendo?" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ahmad Al-Fakhouri, Nephertiti Efeovbokhan, Rami Nakhla, Rami N. Khouzam" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Ahmad" "apellidos" => "Al-Fakhouri" ] 1 => array:2 [ "nombre" => "Nephertiti" "apellidos" => "Efeovbokhan" ] 2 => array:2 [ "nombre" => "Rami" "apellidos" => "Nakhla" ] 3 => array:2 [ "nombre" => "Rami N." "apellidos" => "Khouzam" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S217420491630157X" "doi" => "10.1016/j.repce.2016.06.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217420491630157X?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116301706?idApp=UINPBA00004E" "url" => "/08702551/0000003500000010/v1_201609231322/S0870255116301706/v1_201609231322/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S0870255116301846" "issn" => "08702551" "doi" => "10.1016/j.repc.2016.08.003" "estado" => "S300" "fechaPublicacion" => "2016-10-01" "aid" => "873" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "dis" "cita" => "Rev Port Cardiol. 2016;35:523-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2561 "formatos" => array:3 [ "EPUB" => 192 "HTML" => 1802 "PDF" => 567 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>" "titulo" => "Compacting knowledge in left ventricular non-compaction" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "523" "paginaFinal" => "524" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Compactar o conhecimento na não compactação ventricular esquerda" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alexandra Toste, Nuno Cardim" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Alexandra" "apellidos" => "Toste" ] 1 => array:2 [ "nombre" => "Nuno" "apellidos" => "Cardim" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2174204916301556" "doi" => "10.1016/j.repce.2016.09.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204916301556?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116301846?idApp=UINPBA00004E" "url" => "/08702551/0000003500000010/v1_201609231322/S0870255116301846/v1_201609231322/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Epicardial fat tissue thickness is increased in patients with lichen planus and is linked to inflammation and dyslipidemia" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "525" "paginaFinal" => "530" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Ahmet Goktug Ertem, Mehmet Erdogan, Cemal Koseoglu, Gulsen Akoglu, Elcin Ozdemir, Gamze Koseoglu, Serkan Sivri, Telat Keles, Tahir Durmaz, Akın Aktas, Engin Bozkurt" "autores" => array:11 [ 0 => array:4 [ "nombre" => "Ahmet Goktug" "apellidos" => "Ertem" "email" => array:1 [ 0 => "agertem@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Mehmet" "apellidos" => "Erdogan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Cemal" "apellidos" => "Koseoglu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Gulsen" "apellidos" => "Akoglu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "Elcin" "apellidos" => "Ozdemir" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "Gamze" "apellidos" => "Koseoglu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 6 => array:3 [ "nombre" => "Serkan" "apellidos" => "Sivri" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 7 => array:3 [ "nombre" => "Telat" "apellidos" => "Keles" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 8 => array:3 [ "nombre" => "Tahir" "apellidos" => "Durmaz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 9 => array:3 [ "nombre" => "Akın" "apellidos" => "Aktas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 10 => array:3 [ "nombre" => "Engin" "apellidos" => "Bozkurt" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Cardiology, Yildirim Beyazit University, Ankara, Turkey" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Cardiology, Tokat State Hospital, Tokat, Turkey" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Department of Dermatology, Yildirim Beyazit University, Ankara, Turkey" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Department of Dermatology, Tokat State Hospital, Tokat, Turkey" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Espessura do tecido adiposo epicárdico aumentada em pacientes com líquen plano e relação com inflamação e dislipidemia" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Lichen planus (LP) is a mucocutaneous inflammatory disease that affects 0.5-1% of the population. Its etiology remains unknown; it may be caused by a cell-mediated immunological response in which auto-reactive T4 and T8 lymphocytes are the cytotoxic effector cells which cause degeneration and destruction of keratinocytes.<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">1,2</span></a> LP is associated with lipid disorders, and the inflammatory process may lead to lipid metabolism disturbances such as increased serum triglycerides (TG) and decreased high-density lipoprotein (HDL).<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">3,4</span></a> Inflammation is the predominant mechanical contributor to atherothrombosis and measurement of inflammatory markers could have a role in the management of risk stratification beyond the scope of current global risk assessment.<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">5,6</span></a> It has been hypothesized that the association between LP and cardiovascular risk is due to chronic systemic inflammation.<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">3,6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Epicardial fat tissue (EFT) is the adipose tissue located between the myocardial epicardium and visceral epicardium of the heart. EFT has been shown to produce and secrete various proatherogenic and proinflammatory hormones and cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-6, adipocytokines and leptin.<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">7–9</span></a> Previous studies have demonstrated an association between EFT and insulin resistance, diabetes mellitus, increased cardiometabolic risk, inflammatory markers and coronary artery disease (CAD).<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">10–15</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Like psoriasis, LP is a chronic inflammatory disease. Bacaksız et al. indicate that EFT is significantly increased in patients with psoriasis vulgaris.<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">16</span></a> The aim of this study was to assess EFT in patients with lichen planus.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Patient selection</span><p id="par0020" class="elsevierStylePara elsevierViewall">A total of 54 patients with LP and 50 age-matched controls were enrolled in the study from January 2014 to January 2015. The inclusion criteria for the study group were as follows: men or women aged more than 18 years with LP confirmed according to the clinical and histopathologic criteria established by the World Health Organization. LP was assessed clinically in a standardized dermatological examination by trained and experienced physicians, some of them dermatological consultants. The examination involved the whole body including the scalp and nails. Patients with renal failure, hepatic insufficiency, a history of cardiovascular, cerebrovascular or connective tissue disease, hypertension or epithelial dysplasia were excluded from the study, as were those undergoing systemic treatment with steroids or other drugs, immunosuppressive treatment, retinoids, lipid-lowering therapy, or antihypertensive or antiplatelet drugs. The study was approved by the local ethics committee. Informed consent was obtained from all participants.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Clinical and biochemical parameters</span><p id="par0025" class="elsevierStylePara elsevierViewall">Body height and weight, blood pressure, and body mass index were measured. Serum TG, low-density lipoprotein (LDL) cholesterol, HDL cholesterol, and glucose levels were determined in samples collected after a 12-hour fasting period. Total plasma cholesterol, TG, and HDL cholesterol were measured by an enzymatic colorimetric method using an autoanalyzer (Olympus AU 600) and reagents from Olympus Diagnostics GmbH, Hamburg, Germany. LDL cholesterol levels were calculated by the Friedewald formula. Blood glucose was measured by the glucose oxidase method. Blood was collected in tripotassium EDTA tubes. Blood counts were performed on an XT-1800i Hematology Analyzer (Sysmex Corporation, Kobe, Japan). Baseline neutrophil/lymphocyte ratio (NLR) was determined by dividing neutrophil count by lymphocyte count and baseline platelet/lymphocyte ratio (PLR) by dividing platelet count by lymphocyte count.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Echocardiographic examination</span><p id="par0030" class="elsevierStylePara elsevierViewall">The echocardiographic examination was performed at rest, with the patient in left lateral decubitus position, using a commercially available echocardiographic device (Vivid 7, GE Medical Systems, Milwaukee, WI, USA) with a 3-MHz transducer, by a single experienced echocardiographer (M.E.) who was blinded to the clinical data. Using M-mode echocardiography, long-axis measurements were obtained at the level distal to the mitral valve leaflets according to the current recommendations of the American Society of Echocardiography.<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">17</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Measurement of epicardial fat tissue</span><p id="par0035" class="elsevierStylePara elsevierViewall">EFT was measured on the free wall of the right ventricle in parasternal long-axis view, as previously described and validated.<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">18</span></a> EFT was described as an echo-free space in the pericardial layers on two-dimensional echocardiography, and its thickness was measured perpendicularly to the free wall of the right ventricle at end-systole for 3-10 cardiac cycles. The measurement was performed at a point on the free wall of the right ventricle along the midline of the ultrasound beam, perpendicular to the aortic annulus. In order to increase confidence in the results, EFT measurement was performed at two different times and the percentage of the R-R interval with the least amount of motion was used.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Statistical analysis</span><p id="par0040" class="elsevierStylePara elsevierViewall">The Kolmogorov-Smirnov test was used to assess normal distribution. Continuous variables were expressed as mean<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>SD and categorical variables were expressed as numbers and percentages. The Student's t test was used to compare continuous variables and the Mann-Whitney U test was used for non-normally distributed data. Differences in the distribution of categorical variables were assessed by chi-square analysis. Pearson and Spearman analyses were used for correlation analysis. Multiple linear regression analysis was performed for parameters affecting EFT. p values less than 0.05 were considered statistically significant. SPSS version 16.0 (SPSS, Chicago, IL, USA) was used for all statistical analyses.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><p id="par0045" class="elsevierStylePara elsevierViewall">Demographic, clinical, hematological and biochemical characteristics of patients with LP and control subjects are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. Mean duration of LP was 20.51±11.40 months. No statistical differences was found between LP and controls except in terms of NLR, PLR, EFT thickness, hsCRP and HDL cholesterol (p<0.001, p<0.001, p=0.005, p=0.001, p=0.001 and p=0.001, respectively). There were positive correlations between EFT thickness and PLR, NLR, duration of LP, and hsCRP (p<0.001, p<0.001, p=0.002 and p<0.001, respectively) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). As shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>, in multivariate analysis, after adjustments for relevant confounders, LDL cholesterol, hsCRP, PLR and duration of LP were independent predictors of EFT thickness in patients with LP (β=0.231, p=0.014; β=0.205, p=0.037; β=0.361, p=0.001 and β=0.133, p=0.047, respectively).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">The major findings of our study are that EFT thickness is increased in patients with LP compared to controls, and that duration of LP, LDL cholesterol, hsCRP, and PLR are independent predictors of increased EFT thickness in patients with LP.</p><p id="par0055" class="elsevierStylePara elsevierViewall">LP is an immune-mediated disease of unknown cause that affects the skin, genitalia, mucous membranes and appendages, in which antigens are processed by Langerhans cells and then presented to T lymphocytes. Previous studies showed that patients with LP have high lipid levels, acute phase reactants and atherogenic index. Similar to previous studies, in our population HDL cholesterol levels were lower in patients with LP than controls. Several cytokines, such as TNF-α, IL-2, and IL-6, have been implicated in the increased lipids levels in patients with LP.<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">4,19</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Studies have shown that LP is associated with cardiovascular risk factors including dyslipidemia, diabetes, and increased oxidative stress.<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">3,5,20,21</span></a> Most cardiovascular disorders (including atherosclerosis, hypertension, insulin resistance, dyslipidemia, and arrhythmias) have similar mechanisms, such as chronic inflammation, endothelial dysfunction, and increased oxidative stress.<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">22</span></a> In our study, indirect parameters of oxidative stress levels (PLR and NLR) were higher in patients with LP than in controls.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Saleh et al. have shown that serum homocysteine, fibrinogen and hsCRP are significantly higher in patients with lichen planus.<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">23</span></a> In LP, Th1 inflammatory cytokines such as TNF-α, IL-4, IL-6 and IL-10 are increased in skin and blood.<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">4</span></a> The inflammatory mediators involved in LP may have a range of effects on insulin signaling, lipid metabolism, and adipogenesis.</p><p id="par0070" class="elsevierStylePara elsevierViewall">EFT shares the same embryological origin as intra-abdominal visceral adipose tissue.<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">24</span></a> Similarly to other visceral adipose tissues, epicardial adipose tissue functions as a lipid store that secretes hormones, inflammatory cytokines and chemokines such as TNF-α, monocyte chemoattractant protein (MCP)-1, IL-6 and plasminogen activator inhibitor-1 (PAI-1).<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">25</span></a> EFT is associated with higher levels of atherogenic IL-6 in subjects with CAD.<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">26</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">It is important to identify subclinical atherosclerosis, for which noninvasive tests play an important role. A close association between EFT and subclinical atherosclerosis, coronary calcium score, and presence and severity of coronary stenosis has been reported in several observational studies.<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">27–32</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">EFT (as measured by echocardiography) is associated with increased left ventricular mass, endothelial dysfunction, and the presence and severity of CAD.<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">29</span></a> It is also independently associated with blood pressure, LDL cholesterol, fasting glucose, and both traditional and novel cardiovascular risk factors.<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">33</span></a> Although EFT thickness was increased in patients with LP, we were unable to show these associations in comparisons between patients with LP and control subjects.</p><p id="par0085" class="elsevierStylePara elsevierViewall">EFT is an endocrine and paracrine source of cytokines, and its thickness is correlated with several circulating proatherogenic and proinflammatory adipokines such as visfatin, PAI-1, monocyte chemoattractant protein-1 (MCP-1), and CRP.<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">17,33,34</span></a> However, it is inversely related to adiponectin, an anti-inflammatory and antiatherogenic adipokine.<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">12</span></a> In our study, hsCRP levels correlated with EFT and were an independent predictor of increased EFT thickness.</p><p id="par0090" class="elsevierStylePara elsevierViewall">A recent article by Aksu et al. showed reduced flow-mediated dilatation and increased carotid-intima media thickness, which are predictors of atherosclerosis and cardiovascular end organ damage, in LP patients.<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">35</span></a> In our study, we found that duration of LP is correlated with EFT, and also that duration of LP is an independent predictor of increased EFT, which is a predictor of subclinical atherosclerosis.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Why is EFT thickness increased in patients with LP? One possible underlying mechanism may be persistent inflammation. Inflammatory adipokines such as TNF-α, MCP-1, and IL-6 play a significant role in inflammation and can potentially lead to a predisposition to atherosclerosis.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conclusion</span><p id="par0100" class="elsevierStylePara elsevierViewall">In conclusion, we have shown that patients with LP have more EFT, indicating an increased risk for atherosclerosis. Further long-term prospective studies are needed to clarify the clinical utility and prognostic importance of the link between LP and atherosclerosis.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Ethical disclosures</span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Protection of human and animal subjects</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Confidentiality of data</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data.</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Right to privacy and informed consent</span><p id="par0115" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conflicts of interest</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres733239" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background and Objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec737143" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres733238" "titulo" => "Resumo" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introdução e objetivos" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec737144" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Patient selection" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Clinical and biochemical parameters" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Echocardiographic examination" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Measurement of epicardial fat tissue" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Statistical analysis" ] ] ] 6 => array:2 [ "identificador" => "sec0040" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0045" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0050" "titulo" => "Conclusion" ] 9 => array:3 [ "identificador" => "sec0055" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0060" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0065" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0070" "titulo" => "Right to privacy and informed consent" ] ] ] 10 => array:2 [ "identificador" => "sec0075" "titulo" => "Conflicts of interest" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-01-27" "fechaAceptado" => "2016-04-05" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec737143" "palabras" => array:3 [ 0 => "Echocardiography" 1 => "Epicardial fat tissue" 2 => "Lichen planus" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec737144" "palabras" => array:3 [ 0 => "Ecocardiograma" 1 => "Tecido adiposo epicárdico" 2 => "Líquen plano" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background and Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Lichen planus (LP) is a mucocutaneous inflammatory disease. Inflammation plays a major role in the progression of atherosclerosis. Epicardial fat tissue (EFT) has been shown to produce and secrete various proatherogenic and proinflammatory hormones and cytokines. The aim of this study was to assess EFT in patients with lichen planus.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Fifty-four patients with LP and 50 controls were enrolled in the study. LP was diagnosed according to the World Health Organization criteria. EFT was measured on the free wall of the right ventricle in parasternal long-axis view, as previously described and validated.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">There were positive correlations between EFT thickness and platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, duration of LP, and high-sensitivity C-reactive protein (hsCRP) (p<0.001, p<0.001, p=0.002 and p<0.001, respectively). In multivariate analysis, after adjustments for relevant confounders, LDL cholesterol, hsCRP, platelet/lymphocyte ratio and duration of LP were independent predictors of EFT thickness in patients with LP (β=0.231, p=0.014; β=0.205, p=0.037; β=0.361, p=0.001 and β=0.133, p=0.047, respectively).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">EFT is increased in patients with LP compared to control subjects. Duration of LP is correlated with EFT, and duration of LP is also an independent predictor of increased EFT, which is a predictor of subclinical atherosclerosis.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background and Objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "pt" => array:3 [ "titulo" => "Resumo" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introdução e objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">O líquen plano (LP) é uma doença inflamatória mucocutânea. A inflamação tem um papel importante na progressão da aterosclerose. Demonstrou-se que o tecido adiposo epicárdico (TAE) produz e segrega várias hormonas e citocinas pró-aterogénicas e pró-inflamatórias. O objetivo deste estudo foi a avaliação do TAE em pacientes com LP.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Cinquenta e quatro pacientes com LP e 50 controlos foram inscritos no estudo. O LP foi diagnosticado de acordo com os critérios da Organização Mundial de Saúde. O TAE foi medido na parede livre do ventrículo direito, do ponto de vista do eixo longo para-esternal, conforme descrito e validado anteriormente.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Verificaram-se correlações positivas entre a espessura da gordura epicárdica e a relação linfócitos-plaquetas, a relação neutrófilos-linfócitos, a longevidade do LP, e o hsCRP (p < 0,001, p < 0,001, p = 0,002 e p < 0,001, respetivamente). Após análises multivariadas e ajustamentos para confundidores relevantes (colesterol LDL, hsCRP, relação plaquetas-linfócitos e longevidade do LP), foram confirmados como preditores independentes da espessura da gordura epicárdica em pacientes com LP (β = 0,231, p = 0,014; β = 0,205, p = 0,037; β = 0,361, p = 0,001 e β = 0,133, p = 0,047, respetivamente).</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusão</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">O TAE está aumentado em pacientes com LP em comparação com o grupo de controlo. A longevidade do LP está correlacionada com o TAE, e a sua longevidade é uma variável independente de previsão do TAE aumentado, que por sua vez é uma variável de previsão da aterosclerose subclínica.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introdução e objetivos" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">BMI: body mass index; DBP: diastolic blood pressure; EFT: epicardial fat tissue; HDL: high-density lipoprotein; hsCRP: high-sensitivity C-reactive protein; LDL: low-density lipoprotein; LP: lichen planus; NLR: neutrophil/lymphocyte ratio; PLR: platelet/lymphocyte ratio; SBP: systolic blood pressure; TG: triglycerides; WBC: white blood cell.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patients with LP (n=54) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Controls (n=50) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">45.68±13.01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">47.29±6.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.475 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Female, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">32 (59.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">30 (60.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.866 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">BMI (kg/m<span class="elsevierStyleSup">2</span>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">28.8±4.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">29.4±5.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.518 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SBP (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">126±9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">127±12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.262 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">DBP (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">79±6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">78±9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.577 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Diabetes, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10 (18.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">14 (29.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.221 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Smoking, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">15 (27.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">14 (29.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.284 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hypercholesterolemia, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">22 (40.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13 (26.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.161 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Topical steroid treatment, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">30 (55.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">- \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of LP (months) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">20.51±11.40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">- \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Positive family history, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">17 (31) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8 (17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.111 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">LDL (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">118.5±39.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">117.4±33.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.891 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HDL (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">42.8±10.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">55.4±2.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.005 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TG (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">161±97 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">141±82 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.281 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total cholesterol (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">203±44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">192±36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.207 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Creatinine (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.8±0.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.1±0.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.228 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Blood glucose (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">97±30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">109±37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.101 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hemoglobin (g/l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">11.4±3.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12.1±2.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.475 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WBC count (10<span class="elsevierStyleSup">3</span>/μl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7.6±1.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7.5±1.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.772 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NLR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.1±1.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.8±0.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PLR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">165±31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">107±26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">EFT thickness (mm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.89±0.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.53±0.11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">hsCRP (mg/l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4.67±3.35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.48±0.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1210008.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Baseline demographic, clinical, hematological and biochemical characteristics of study and control subjects.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">HDL: high-density lipoprotein; hsCRP: high-sensitivity C-reactive protein; LP: lichen planus; NLR: neutrophil/lymphocyte ratio; PLR: platelet/lymphocyte ratio; WBC: white blood cell.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">R \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WBC count \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.007 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.943 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NLR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.359 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PLR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.487 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HDL cholesterol \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.090 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.384 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of LP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.318 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">hsCRP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.405 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1210009.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Correlation analysis of epicardial fat tissue and confounding variables.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">HDL: high-density lipoprotein; hsCRP: high-sensitivity C-reactive protein; LDL: low-density lipoprotein; LP: lichen planus; LVEF: left ventricular ejection fraction; NLR: neutrophil/lymphocyte ratio; PLR: platelet/lymphocyte ratio.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">β \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.101 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.275 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Diabetes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">-0.164 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.062 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Smoking \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.027 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.765 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">LDL cholesterol \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.231 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.014 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HDL cholesterol \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">-0.060 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.492 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">hsCRP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.205 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.037 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NLR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.179 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.069 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PLR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.361 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">LVEF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">-0.071 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.408 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of LP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.133 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.047 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1210010.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Multivariate linear regression analysis of predictors of epicardial fat tissue in patients with lichen planus.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:35 [ 0 => array:3 [ "identificador" => "bib0180" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infiltrating CD8+ T cells in oral lichen planus predominantly express CCR5 and CXCR3 and carry respective chemokine ligands RANTES/CCL5 and IP-10/CXCL10 in their cytolytic granules: a potential self-recruiting mechanism" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "W. Iijima" 1 => "H. Ohtani" 2 => "T. Nakayama" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0002-9440(10)63649-8" "Revista" => array:6 [ "tituloSerie" => "Am J Pathol" "fecha" => "2003" "volumen" => "163" "paginaInicial" => "261" "paginaFinal" => "268" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12819030" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0185" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical variants of lichen planus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Wagner" 1 => "C. Rose" 2 => "M.M. Sachse" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ddg.12031" "Revista" => array:7 [ "tituloSerie" => "J Dtsch Dermatol Ges" "fecha" => "2013" "volumen" => "11" "paginaInicial" => "309" "paginaFinal" => "319" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23320493" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016508511002708" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0190" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lichen planus and dyslipidaemia: a case-control study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Dreiher" 1 => "J. Shapiro" 2 => "A.D. Cohen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2009.09235.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2009" "volumen" => "161" "paginaInicial" => "626" "paginaFinal" => "629" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19438850" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0195" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lipid levels in patients with lichen planus: a case-control study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Arias-Santiago" 1 => "A. Buendia-Eisman" 2 => "J. Aneiros-Fernandez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2011.03983.x" "Revista" => array:7 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2011" "volumen" => "25" "paginaInicial" => "1398" "paginaFinal" => "1401" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21348899" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S016882780900734X" "estado" => "S300" "issn" => "01688278" ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0200" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular risk factors in patients with lichen planus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Arias-Santiago" 1 => "A. Buendia-Eisman" 2 => "J. Aneiros-Fernandez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjmed.2010.12.025" "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "2011" "volumen" => "124" "paginaInicial" => "543" "paginaFinal" => "548" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21605731" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0205" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Common oral mucosal diseases, systemic inflammation and cardiovascular diseases in a large cross-sectional US survey" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Fedele" 1 => "W. Sabbah" 2 => "N. Donos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ahj.2010.11.009" "Revista" => array:6 [ "tituloSerie" => "Am Heart J" "fecha" => "2011" "volumen" => "161" "paginaInicial" => "344" "paginaFinal" => "350" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21315218" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0210" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human epicardial adipose tissue is a source of inflammatory mediators" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "T. Mazurek" 1 => "L. Zhang" 2 => "A. Zalewski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.CIR.0000099542.57313.C5" "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2003" "volumen" => "108" "paginaInicial" => "2460" "paginaFinal" => "2466" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14581396" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0215" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epicardial adipose tissue and coronary artery plaque characteristics" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N. Alexopoulos" 1 => "D.S. McLean" 2 => "M. Janik" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.atherosclerosis.2009.11.020" "Revista" => array:6 [ "tituloSerie" => "Atherosclerosis" "fecha" => "2010" "volumen" => "210" "paginaInicial" => "150" "paginaFinal" => "154" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20031133" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0220" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Paracrine role for periadventitial adipose tissue in the regulation of arterial tone" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Gollasch" 1 => "G. Dubrovska" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.tips.2004.10.005" "Revista" => array:7 [ "tituloSerie" => "Trends Pharmacol Sci" "fecha" => "2004" "volumen" => "25" "paginaInicial" => "647" "paginaFinal" => "653" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15530643" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1542356515002992" "estado" => "S300" "issn" => "15423565" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0225" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epicardial adipose tissue and insulin resistance in obese subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Iacobellis" 1 => "F. Leonetti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jc.2005-1087" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2005" "volumen" => "90" "paginaInicial" => "6300" "paginaFinal" => "6302" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16091479" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0230" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pericardial adipose tissue, atherosclerosis, and cardiovascular disease risk factors: the Jackson heart study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Liu" 1 => "C.S. Fox" 2 => "D. Hickson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2337/dc10-0245" "Revista" => array:6 [ "tituloSerie" => "Diabetes Care" "fecha" => "2010" "volumen" => "33" "paginaInicial" => "1635" "paginaFinal" => "1639" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20413524" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0235" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Iacobellis" 1 => "M.C. Ribaudo" 2 => "F. Assael" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jc.2003-030698" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2003" "volumen" => "88" "paginaInicial" => "5163" "paginaFinal" => "5168" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14602744" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0240" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Secretory type II phospholipase A2 is produced and secreted by epicardial adipose tissue and overexpressed in patients with coronary artery disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Dutour" 1 => "V. Achard" 2 => "H. Sell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jc.2009-1222" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2010" "volumen" => "95" "paginaInicial" => "963" "paginaFinal" => "967" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20008021" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0245" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K.H. Cheng" 1 => "C.S. Chu" 2 => "K.T. Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Obes" "fecha" => "2008" "volumen" => "32" "paginaInicial" => "268" "paginaFinal" => "274" "itemHostRev" => array:3 [ "pii" => "S0016508512002302" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0250" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epicardial fat thickness and coronary artery disease correlate independently of obesity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Iacobellis" 1 => "E. Lonn" 2 => "A. Lamy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijcard.2010.10.117" "Revista" => array:7 [ "tituloSerie" => "Int J Cardiol" "fecha" => "2011" "volumen" => "146" "paginaInicial" => "452" "paginaFinal" => "454" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21094545" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0168827813001918" "estado" => "S300" "issn" => "01688278" ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0255" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epicardial fat thickness in patients with psoriasis vulgaris" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Bacaksız" 1 => "A. Tasal" 2 => "E. Sevgili" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Turk Soc Cardiol" "fecha" => "2014" "volumen" => "42" "paginaInicial" => "47" "paginaFinal" => "54" "itemHostRev" => array:3 [ "pii" => "S1542356513013207" "estado" => "S300" "issn" => "15423565" ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0260" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R.M. Lang" 1 => "M. Bierig" 2 => "R.B. Devereux" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.echo.2005.10.005" "Revista" => array:6 [ "tituloSerie" => "J Am Soc Echocardiogr" "fecha" => "2005" "volumen" => "18" "paginaInicial" => "1440" "paginaFinal" => "1463" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16376782" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0265" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Iacobellis" 1 => "D. Corradi" 2 => "A.M. Sharma" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ncpcardio0319" "Revista" => array:7 [ "tituloSerie" => "Nat Clin Pract Cardiovasc Med" "fecha" => "2005" "volumen" => "2" "paginaInicial" => "536" "paginaFinal" => "543" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16186852" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0168827815002597" "estado" => "S300" "issn" => "01688278" ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0270" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alterations in serum lipid profile patterns in oral lichen planus: a cross-sectional study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. Lopez-Jornet" 1 => "F. Camacho-Alonso" 2 => "M.A. Rodriguez-Martines" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2165/11633600-000000000-00000" "Revista" => array:7 [ "tituloSerie" => "Am J Clin Dermatol" "fecha" => "2012" "volumen" => "13" "paginaInicial" => "399" "paginaFinal" => "404" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22924867" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0168827813008842" "estado" => "S300" "issn" => "01688278" ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0275" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High prevalence of glucose metabolism disturbance in patients with lichen planus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Seyhan" 1 => "H. Ozcan" 2 => "I. Sahin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabet Res Clin Pract" "fecha" => "2007" "volumen" => "77" "paginaInicial" => "198" "paginaFinal" => "202" "itemHostRev" => array:3 [ "pii" => "S0168827810008251" "estado" => "S300" "issn" => "01688278" ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0280" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oxidative stress in lichen planus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.G. Aly" 1 => "R.S. Shahin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Dermatovenerol Alp Panon Adriat" "fecha" => "2010" "volumen" => "19" "paginaInicial" => "3" "paginaFinal" => "11" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0285" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis and atherosclerosis: two plaques, one syndrome?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.J. Flammer" 1 => "F. Ruschitzka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehr425" "Revista" => array:7 [ "tituloSerie" => "Eur Heart J" "fecha" => "2012" "volumen" => "33" "paginaInicial" => "1989" "paginaFinal" => "1991" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22108835" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S001650850800108X" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0290" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Homocysteine and other cardiovascular risk factors in patients with lichen planus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N. Saleh" 1 => "N. Samir" 2 => "H. Megahed" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.12329" "Revista" => array:6 [ "tituloSerie" => "JEADV" "fecha" => "2014" "volumen" => "28" "paginaInicial" => "1507" "paginaFinal" => "1513" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24330130" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0295" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adipose tissue in the mammalian heart and pericardium: structure, foetal development and biochemical properties" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.M. Marchington" 1 => "C.A. Mattacks" 2 => "C.M. Pond" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Comp Biochem Physiol B" "fecha" => "1989" "volumen" => "94" "paginaInicial" => "225" "paginaFinal" => "232" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2591189" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0300" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.R. Baker" 1 => "N.F. Silva" 2 => "D.W. Quinn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1475-2840-5-1" "Revista" => array:5 [ "tituloSerie" => "Cardiovasc Diabetol" "fecha" => "2006" "volumen" => "5" "paginaInicial" => "1" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16412224" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0305" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extension of coronary artery disease is associated with increased IL-6 and decreased adiponectin gene expression in epicardial adipose tissue" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Eiras" 1 => "E. Teijeira-Fernandez" 2 => "L.G. Shamagian" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cyto.2008.05.006" "Revista" => array:6 [ "tituloSerie" => "Cytokine" "fecha" => "2008" "volumen" => "43" "paginaInicial" => "174" "paginaFinal" => "180" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18562207" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0310" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation of echocardiographic epicardial fat thickness with severity of coronary artery disease – an observational study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. Shemirani" 1 => "M. Khoshavi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5152/akd.2012.061" "Revista" => array:6 [ "tituloSerie" => "Anadolu Kardiyol Derg" "fecha" => "2012" "volumen" => "12" "paginaInicial" => "200" "paginaFinal" => "205" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22366102" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0315" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "How to interpret epicardial adipose tissue as a cause of coronary artery disease: a meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "Y. Xu" 1 => "X. Cheng" 2 => "K. Hong" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MCA.0b013e328351ab2c" "Revista" => array:7 [ "tituloSerie" => "Coron Artery Dis" "fecha" => "2012" "volumen" => "23" "paginaInicial" => "227" "paginaFinal" => "233" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22361934" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1542356514006028" "estado" => "S300" "issn" => "15423565" ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0320" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epicardial fat: an additional measurement for subclinical atherosclerosis and cardiovascular risk stratification?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.R. Nelson" 1 => "F. Mookadam" 2 => "V. Thota" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.echo.2010.11.008" "Revista" => array:6 [ "tituloSerie" => "J Am Soc Echocardiogr" "fecha" => "2011" "volumen" => "24" "paginaInicial" => "339" "paginaFinal" => "345" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21185148" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0325" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relation of epicardial and pericoronary fat to coronary atherosclerosis and coronary artery calcium in patients undergoing coronary angiography" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P.M. Gorter" 1 => "A.M. de Vos" 2 => "Y. van der Graaf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjcard.2008.04.002" "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "2008" "volumen" => "102" "paginaInicial" => "380" "paginaFinal" => "385" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18678291" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0330" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The association of pericardial fat with calcified coronary plaque" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Ding" 1 => "S.B. Kritchevsky" 2 => "T.B. Harris" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/oby.2008.278" "Revista" => array:6 [ "tituloSerie" => "Obesity" "fecha" => "2008" "volumen" => "16" "paginaInicial" => "1914" "paginaFinal" => "1919" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18535554" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0335" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The association of pericardial fat with coronary artery plaque index at MR imaging: The Multi-Ethnic Study of Atherosclerosis (MESA)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C. Miao" 1 => "S. Chen" 2 => "J. Ding" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/radiol.11110346" "Revista" => array:6 [ "tituloSerie" => "Radiology" "fecha" => "2011" "volumen" => "261" "paginaInicial" => "109" "paginaFinal" => "115" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21846753" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0340" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Echocardiographic epicardial fat: a review of research and clinical applications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Iacobellis" 1 => "H.J. Willens" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.echo.2009.10.013" "Revista" => array:6 [ "tituloSerie" => "J Am Soc Echocardiogr" "fecha" => "2009" "volumen" => "22" "paginaInicial" => "1311" "paginaFinal" => "1319" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19944955" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0345" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epicardial fat thickness: relationship with plasma visfatin and plasminogen activator inhibitor-1 levels in visceral obesity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.E. Malavazos" 1 => "F. Ermetici" 2 => "E. Cereda" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.numecd.2007.09.001" "Revista" => array:6 [ "tituloSerie" => "Nutr Metab Cardiovasc Dis" "fecha" => "2008" "volumen" => "18" "paginaInicial" => "523" "paginaFinal" => "530" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18083357" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0350" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Aksu F, Karadag AS, Caliskan M, et al. Does lichen planus cause increased carotid intima-media thickness and impaired endothelial function? Can J Cardiol [Epub ahead of print] <a id="intr0005" class="elsevierStyleInterRef" href="http://dx.doi.org/10.1016/j.cjca.2015.11.016">doi:10.1016/j.cjca.2015.11.016</a>." ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/08702551/0000003500000010/v1_201609231322/S0870255116301676/v1_201609231322/en/main.assets" "Apartado" => array:4 [ "identificador" => "29261" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Artigos Originais" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/08702551/0000003500000010/v1_201609231322/S0870255116301676/v1_201609231322/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116301676?idApp=UINPBA00004E" ]
Ano/Mês | Html | Total | |
---|---|---|---|
2024 Novembro | 8 | 5 | 13 |
2024 Outubro | 41 | 29 | 70 |
2024 Setembro | 49 | 26 | 75 |
2024 Agosto | 44 | 27 | 71 |
2024 Julho | 47 | 31 | 78 |
2024 Junho | 30 | 24 | 54 |
2024 Maio | 53 | 22 | 75 |
2024 Abril | 44 | 30 | 74 |
2024 Maro | 56 | 21 | 77 |
2024 Fevereiro | 40 | 17 | 57 |
2024 Janeiro | 38 | 33 | 71 |
2023 Dezembro | 50 | 20 | 70 |
2023 Novembro | 55 | 34 | 89 |
2023 Outubro | 33 | 33 | 66 |
2023 Setembro | 33 | 20 | 53 |
2023 Agosto | 27 | 23 | 50 |
2023 Julho | 17 | 18 | 35 |
2023 Junho | 32 | 21 | 53 |
2023 Maio | 52 | 29 | 81 |
2023 Abril | 27 | 8 | 35 |
2023 Maro | 62 | 28 | 90 |
2023 Fevereiro | 42 | 27 | 69 |
2023 Janeiro | 30 | 10 | 40 |
2022 Dezembro | 59 | 23 | 82 |
2022 Novembro | 54 | 27 | 81 |
2022 Outubro | 47 | 22 | 69 |
2022 Setembro | 41 | 32 | 73 |
2022 Agosto | 34 | 26 | 60 |
2022 Julho | 34 | 42 | 76 |
2022 Junho | 26 | 35 | 61 |
2022 Maio | 32 | 26 | 58 |
2022 Abril | 41 | 33 | 74 |
2022 Maro | 34 | 41 | 75 |
2022 Fevereiro | 33 | 32 | 65 |
2022 Janeiro | 30 | 24 | 54 |
2021 Dezembro | 21 | 24 | 45 |
2021 Novembro | 35 | 33 | 68 |
2021 Outubro | 30 | 34 | 64 |
2021 Setembro | 18 | 30 | 48 |
2021 Agosto | 36 | 34 | 70 |
2021 Julho | 20 | 30 | 50 |
2021 Junho | 23 | 18 | 41 |
2021 Maio | 34 | 30 | 64 |
2021 Abril | 65 | 43 | 108 |
2021 Maro | 68 | 25 | 93 |
2021 Fevereiro | 52 | 12 | 64 |
2021 Janeiro | 39 | 17 | 56 |
2020 Dezembro | 42 | 18 | 60 |
2020 Novembro | 29 | 29 | 58 |
2020 Outubro | 32 | 20 | 52 |
2020 Setembro | 63 | 7 | 70 |
2020 Agosto | 21 | 6 | 27 |
2020 Julho | 45 | 13 | 58 |
2020 Junho | 42 | 18 | 60 |
2020 Maio | 42 | 8 | 50 |
2020 Abril | 50 | 9 | 59 |
2020 Maro | 37 | 13 | 50 |
2020 Fevereiro | 99 | 50 | 149 |
2020 Janeiro | 44 | 9 | 53 |
2019 Dezembro | 32 | 14 | 46 |
2019 Novembro | 38 | 8 | 46 |
2019 Outubro | 37 | 10 | 47 |
2019 Setembro | 30 | 8 | 38 |
2019 Agosto | 45 | 9 | 54 |
2019 Julho | 44 | 11 | 55 |
2019 Junho | 38 | 15 | 53 |
2019 Maio | 50 | 13 | 63 |
2019 Abril | 23 | 19 | 42 |
2019 Maro | 61 | 8 | 69 |
2019 Fevereiro | 78 | 15 | 93 |
2019 Janeiro | 49 | 8 | 57 |
2018 Dezembro | 64 | 10 | 74 |
2018 Novembro | 103 | 12 | 115 |
2018 Outubro | 240 | 11 | 251 |
2018 Setembro | 68 | 8 | 76 |
2018 Agosto | 30 | 13 | 43 |
2018 Julho | 22 | 8 | 30 |
2018 Junho | 27 | 4 | 31 |
2018 Maio | 26 | 17 | 43 |
2018 Abril | 35 | 3 | 38 |
2018 Maro | 43 | 12 | 55 |
2018 Fevereiro | 22 | 3 | 25 |
2018 Janeiro | 18 | 8 | 26 |
2017 Dezembro | 52 | 9 | 61 |
2017 Novembro | 43 | 9 | 52 |
2017 Outubro | 31 | 11 | 42 |
2017 Setembro | 38 | 11 | 49 |
2017 Agosto | 41 | 12 | 53 |
2017 Julho | 24 | 12 | 36 |
2017 Junho | 35 | 10 | 45 |
2017 Maio | 22 | 12 | 34 |
2017 Abril | 17 | 4 | 21 |
2017 Maro | 21 | 3 | 24 |
2017 Fevereiro | 18 | 10 | 28 |
2017 Janeiro | 27 | 8 | 35 |
2016 Dezembro | 48 | 25 | 73 |
2016 Novembro | 34 | 21 | 55 |
2016 Outubro | 63 | 61 | 124 |
2016 Setembro | 28 | 45 | 73 |