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Multiple high-pressure dilatations were performed with a 3 mm non-compliant balloon&#44; with clear lumen improvement but still with a suboptimal angiographic result &#40;intrastent haziness with residual stenosis&#41;&#46; A 3&#46;0 mm bioresorbable vascular scaffold &#40;BVS&#41; &#40;Abbott Vascular&#44; Santa Clara&#44; CA&#44; USA&#41; was implanted and subsequently postdilated with a 3&#46;25 mm non-compliant balloon at 20 bar&#44; with an excellent final angiographic result &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>B&#41;&#46; Repeat OCT disclosed a properly apposed and expanded device&#46; The characteristic image of the BVS struts &#40;box-like appearance without dorsal shadowing&#41; was clearly identified against the underlying residual neointimal or atherosclerotic tissue over the underlying metallic stent &#40;bright struts with clear-cut posterior shadow&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>A&#41;&#46; There was a moderate rise in cardiac enzymes &#40;peak high-sensitive troponin T 1115 ng&#47;l&#44; peak creatinine kinase 309 U&#47;l&#41; but the clinical course was uneventful and the patient was discharged on aspirin and prasugrel three days later&#46; Unfortunately&#44; three months later the patient himself decided to stop dual antiplatelet therapy&#46; After four days without medication&#44; he suffered a new anterior myocardial infarction&#46; Emergent coronary angiography revealed a thrombosis of the BVS&#44; which was successfully treated with thromboaspiration and dilatation with a non-compliant balloon &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>B&#41;&#46; Six months later the patient remains asymptomatic with good adherence to treatment&#46; A scheduled coronary angiography at this time confirmed an excellent result in the target segment&#46; OCT showed a well expanded and apposed BVS with complete neointimal coverage &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>C and D&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discussion</span><p id="par0010" class="elsevierStylePara elsevierViewall">Very late stent thrombosis is a rare but devastating complication after percutaneous coronary revascularization&#46; Stent thrombosis may be due to a mechanical problem such as stent malapposition or underexpansion&#46; On the other hand&#44; pathological studies have demonstrated that neoatherosclerosis plays a major role in certain patients with very late stent thrombosis&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> Interestingly&#44; neoatherosclerosis occurs not only more frequently but also earlier in patients treated with drug-eluting stents compared with those treated with bare-metal stents&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> When the thrombosis is related to stent malapposition or underexpansion&#44; balloon angioplasty without stent deployment is sufficient in most cases&#46; However&#44; the therapy of choice for patients presenting with very late in-stent restenosis or very late stent thrombosis as a result of neoatherosclerosis remains unclear&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2&#44;3</span></a> In this context the use of BVS is a potentially attractive strategy to avoid the implantation of an additional metal layer while ensuring an optimal acute result and benefiting from their unique antirestenotic efficacy&#59; in addition&#44; they may promote plaque stability and passivation of vulnerable plaques by providing a uniform homogeneous neointimal layer&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> In this regard&#44; some preliminary reports have suggested the value of BVS in patients with in-stent restenosis&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> However&#44; the use of BVS in patients with very late stent thrombosis has not been previously reported&#46; Currently&#44; neoatherosclerosis may be readily recognized using OCT at a resolution of 15 &#956;m&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> This technique is able to unravel the underlying pathological substrate in patients presenting with stent failure&#46; The unique insights provided by OCT may help to tackle underlying mechanical problems such as stent malapposition or underexpansion and neoatherosclerosis&#44; and also to optimize BVS deployment&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Our findings suggest the value of BVS for the treatment of selected patients suffering from very late stent thrombosis as a result of neoatherosclerosis&#46; However&#44; only prospective studies will be able to establish the potential role of this novel form of therapy in this challenging anatomic scenario&#46; In addition&#44; the subsequent episode of BVS thrombosis&#44; which in our case was closely related to lack of adherence to prescribed medications&#44; reminds us of the important role of patient education and counseling to ensure the maintenance of appropriate dual antiplatelet therapy&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Ethical disclosures</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Protection of human and animal subjects</span><p id="par0020" class="elsevierStylePara elsevierViewall">The authors declare that the procedures followed were in accordance with the regulations of the relevant clinical research ethics committee and with those of the Code of Ethics of the World Medical Association &#40;Declaration of Helsinki&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Confidentiality of data</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Right to privacy and informed consent</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; 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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Very late stent thrombosis is a rare but devastating complication after percutaneous coronary revascularization&#46; Pathological studies have demonstrated that neoatherosclerosis plays a major role in certain patients with very late stent thrombosis&#46; Optical coherence tomography is able to unravel the underlying pathophysiology and may be used to select the best treatment option&#46; This case report describes the use of a bioresorbable vascular scaffold &#40;BVS&#41; in a patient suffering from very late stent thrombosis due to a complicated plaque in the setting of intrastent neoatherosclerosis&#46; To our knowledge&#44; this therapeutic strategy has not been previously reported in patients suffering from very late stent thrombosis&#46; In this scenario&#44; BVS implantation might represent an attractive strategy in selected patients&#46;</p></span>"
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Case report
Bioresorbable vascular scaffold for very late stent thrombosis resulting from ruptured neoatherosclerosis
Plataformas biorreabsorbíveis no tratamento da trombose de stent muito tardia resultante de rotura de neoaterosclerose
Teresa Bastante, Fernando Rivero, Javier Cuesta, M. Cruz Aguilera, Daniel Rodríguez, Amparo Benedicto, Fernando Alfonso
Autor para correspondência
falf@hotmail.com

Corresponding author.
Cardiac Department, Hospital Universitario de La Princesa, Madrid, Spain
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Multiple high-pressure dilatations were performed with a 3 mm non-compliant balloon&#44; with clear lumen improvement but still with a suboptimal angiographic result &#40;intrastent haziness with residual stenosis&#41;&#46; A 3&#46;0 mm bioresorbable vascular scaffold &#40;BVS&#41; &#40;Abbott Vascular&#44; Santa Clara&#44; CA&#44; USA&#41; was implanted and subsequently postdilated with a 3&#46;25 mm non-compliant balloon at 20 bar&#44; with an excellent final angiographic result &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>B&#41;&#46; Repeat OCT disclosed a properly apposed and expanded device&#46; The characteristic image of the BVS struts &#40;box-like appearance without dorsal shadowing&#41; was clearly identified against the underlying residual neointimal or atherosclerotic tissue over the underlying metallic stent &#40;bright struts with clear-cut posterior shadow&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>A&#41;&#46; There was a moderate rise in cardiac enzymes &#40;peak high-sensitive troponin T 1115 ng&#47;l&#44; peak creatinine kinase 309 U&#47;l&#41; but the clinical course was uneventful and the patient was discharged on aspirin and prasugrel three days later&#46; Unfortunately&#44; three months later the patient himself decided to stop dual antiplatelet therapy&#46; After four days without medication&#44; he suffered a new anterior myocardial infarction&#46; Emergent coronary angiography revealed a thrombosis of the BVS&#44; which was successfully treated with thromboaspiration and dilatation with a non-compliant balloon &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>B&#41;&#46; Six months later the patient remains asymptomatic with good adherence to treatment&#46; A scheduled coronary angiography at this time confirmed an excellent result in the target segment&#46; OCT showed a well expanded and apposed BVS with complete neointimal coverage &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>C and D&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discussion</span><p id="par0010" class="elsevierStylePara elsevierViewall">Very late stent thrombosis is a rare but devastating complication after percutaneous coronary revascularization&#46; Stent thrombosis may be due to a mechanical problem such as stent malapposition or underexpansion&#46; On the other hand&#44; pathological studies have demonstrated that neoatherosclerosis plays a major role in certain patients with very late stent thrombosis&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> Interestingly&#44; neoatherosclerosis occurs not only more frequently but also earlier in patients treated with drug-eluting stents compared with those treated with bare-metal stents&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> When the thrombosis is related to stent malapposition or underexpansion&#44; balloon angioplasty without stent deployment is sufficient in most cases&#46; However&#44; the therapy of choice for patients presenting with very late in-stent restenosis or very late stent thrombosis as a result of neoatherosclerosis remains unclear&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2&#44;3</span></a> In this context the use of BVS is a potentially attractive strategy to avoid the implantation of an additional metal layer while ensuring an optimal acute result and benefiting from their unique antirestenotic efficacy&#59; in addition&#44; they may promote plaque stability and passivation of vulnerable plaques by providing a uniform homogeneous neointimal layer&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> In this regard&#44; some preliminary reports have suggested the value of BVS in patients with in-stent restenosis&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> However&#44; the use of BVS in patients with very late stent thrombosis has not been previously reported&#46; Currently&#44; neoatherosclerosis may be readily recognized using OCT at a resolution of 15 &#956;m&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> This technique is able to unravel the underlying pathological substrate in patients presenting with stent failure&#46; The unique insights provided by OCT may help to tackle underlying mechanical problems such as stent malapposition or underexpansion and neoatherosclerosis&#44; and also to optimize BVS deployment&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Our findings suggest the value of BVS for the treatment of selected patients suffering from very late stent thrombosis as a result of neoatherosclerosis&#46; However&#44; only prospective studies will be able to establish the potential role of this novel form of therapy in this challenging anatomic scenario&#46; In addition&#44; the subsequent episode of BVS thrombosis&#44; which in our case was closely related to lack of adherence to prescribed medications&#44; reminds us of the important role of patient education and counseling to ensure the maintenance of appropriate dual antiplatelet therapy&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Ethical disclosures</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Protection of human and animal subjects</span><p id="par0020" class="elsevierStylePara elsevierViewall">The authors declare that the procedures followed were in accordance with the regulations of the relevant clinical research ethics committee and with those of the Code of Ethics of the World Medical Association &#40;Declaration of Helsinki&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Confidentiality of data</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Right to privacy and informed consent</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conflicts of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Very late stent thrombosis is a rare but devastating complication after percutaneous coronary revascularization&#46; Pathological studies have demonstrated that neoatherosclerosis plays a major role in certain patients with very late stent thrombosis&#46; Optical coherence tomography is able to unravel the underlying pathophysiology and may be used to select the best treatment option&#46; This case report describes the use of a bioresorbable vascular scaffold &#40;BVS&#41; in a patient suffering from very late stent thrombosis due to a complicated plaque in the setting of intrastent neoatherosclerosis&#46; To our knowledge&#44; this therapeutic strategy has not been previously reported in patients suffering from very late stent thrombosis&#46; In this scenario&#44; BVS implantation might represent an attractive strategy in selected patients&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A trombose de <span class="elsevierStyleItalic">stent</span> muito tardia &#233; uma complica&#231;&#227;o rara mas preocupante ap&#243;s a revasculariza&#231;&#227;o coron&#225;ria percut&#226;nea&#46; Estudos patol&#243;gicos t&#234;m demonstrado que a neoaterosclerose desempenha um papel importante em doentes selecionados com trombose de <span class="elsevierStyleItalic">stent</span> muito tardia&#46; A tomografia de coer&#234;ncia &#243;tica contribui para a compreens&#227;o da fisiopatologia subjacente&#44; permitindo selecionar a melhor op&#231;&#227;o de tratamento&#46; No presente caso descrevemos a utiliza&#231;&#227;o de um <span class="elsevierStyleItalic">stent</span> vascular bioabsorv&#237;vel num doente que apresentava trombose de <span class="elsevierStyleItalic">stent</span> muito tardia devido a placa complexa no contexto de neoaterosclerose intrastent&#46; De acordo com a nossa experi&#234;ncia&#44; esta estrat&#233;gia terap&#234;utica n&#227;o tem sido apresentada em doentes com trombose de <span class="elsevierStyleItalic">stent</span> muito avan&#231;ada&#46; Neste cen&#225;rio&#44; a implanta&#231;&#227;o de suportes vasculares bioabsorb&#237;veis pode representar uma estrat&#233;gia atrativa em doentes selecionados&#46;</p></span>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Coronary angiography in cranial view showing the occluded left anterior descending coronary artery &#40;arrow&#41;&#59; &#40;B&#41; final angiographic result after bioresorbable vascular scaffold deployment&#59; &#40;C&#41; optical coherence tomography &#40;OCT&#41; image after thrombus aspiration showing heterogeneous intrastent tissue with large lipid pools &#40;&#43;&#41;&#46; Some stent struts are poorly detected due to attenuation&#46; There is also calcified tissue &#40;Ca&#41; surrounding some struts&#46; Note plaque rupture &#40;arrow&#41;&#59; &#40;D&#41; OCT image after thrombus aspiration showing residual red thrombus &#40;T&#41; in an area with complete neointimal coverage&#46; &#40;&#42;&#41; denotes wire artifact&#59; &#40;E&#41; 3D reconstruction of OCT image after thrombus aspiration with severe stenosis due to intrastent tissue &#40;c&#41; and residual red thrombus &#40;T&#41; &#40;d&#41;&#46;</p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Optical coherence tomography &#40;OCT&#41; findings after bioresorbable vascular scaffold &#40;BVS&#41; implantation&#46; The device was fully expanded and apposed&#46; The metallic struts of the underlying stent are clearly detected &#40;posterior shadow&#41; in the far field&#59; &#40;B&#41; OCT findings during BVS thrombosis&#44; with large platelet-rich thrombus &#40;pT&#41; occupying the lumen and the characteristic box-like appearance of the BVS struts&#59; &#40;C&#41; OCT after six months&#46; Notice complete neointimal coverage of struts&#46; &#40;&#42;&#41; denotes wire artifact&#59; &#40;D&#41; 3D reconstruction of OCT image after six months&#46;</p>"
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2022 Julho 40 41 81
2022 Junho 27 26 53
2022 Maio 28 34 62
2022 Abril 44 34 78
2022 Maro 32 37 69
2022 Fevereiro 27 27 54
2022 Janeiro 22 28 50
2021 Dezembro 23 42 65
2021 Novembro 43 38 81
2021 Outubro 47 41 88
2021 Setembro 31 29 60
2021 Agosto 39 33 72
2021 Julho 23 17 40
2021 Junho 23 32 55
2021 Maio 36 37 73
2021 Abril 37 51 88
2021 Maro 86 23 109
2021 Fevereiro 94 21 115
2021 Janeiro 55 14 69
2020 Dezembro 41 14 55
2020 Novembro 38 23 61
2020 Outubro 21 12 33
2020 Setembro 60 19 79
2020 Agosto 20 8 28
2020 Julho 41 13 54
2020 Junho 32 12 44
2020 Maio 41 7 48
2020 Abril 49 22 71
2020 Maro 50 7 57
2020 Fevereiro 65 15 80
2020 Janeiro 36 14 50
2019 Dezembro 35 17 52
2019 Novembro 50 9 59
2019 Outubro 39 6 45
2019 Setembro 33 8 41
2019 Agosto 38 6 44
2019 Julho 54 8 62
2019 Junho 45 23 68
2019 Maio 61 7 68
2019 Abril 36 16 52
2019 Maro 118 13 131
2019 Fevereiro 102 12 114
2019 Janeiro 100 5 105
2018 Dezembro 83 15 98
2018 Novembro 125 10 135
2018 Outubro 247 37 284
2018 Setembro 85 14 99
2018 Agosto 45 16 61
2018 Julho 48 9 57
2018 Junho 75 4 79
2018 Maio 87 7 94
2018 Abril 88 3 91
2018 Maro 103 6 109
2018 Fevereiro 65 10 75
2018 Janeiro 71 4 75
2017 Dezembro 105 8 113
2017 Novembro 51 9 60
2017 Outubro 44 16 60
2017 Setembro 93 7 100
2017 Agosto 84 10 94
2017 Julho 58 7 65
2017 Junho 54 11 65
2017 Maio 134 7 141
2017 Abril 52 4 56
2017 Maro 62 50 112
2017 Fevereiro 115 9 124
2017 Janeiro 60 3 63
2016 Dezembro 37 13 50
2016 Novembro 44 11 55
2016 Outubro 58 7 65
2016 Setembro 91 7 98
2016 Agosto 47 4 51
2016 Julho 12 7 19
2016 Junho 4 6 10
2016 Maio 12 10 22
2016 Abril 35 2 37
2016 Maro 50 12 62
2016 Fevereiro 59 24 83
2016 Janeiro 88 62 150
2015 Dezembro 73 51 124
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