que se leu este artigo
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NYHA: New York Heart Association.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Valdano Manuel, Humberto Morais, Manuel Pedro Magalhães, Maria Ana Sampaio Nunes, Gilberto Leon, Manuel Ferreira, António Pedro Filipe Júnior" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Valdano" "apellidos" => "Manuel" ] 1 => array:2 [ "nombre" => "Humberto" "apellidos" => "Morais" ] 2 => array:2 [ "nombre" => "Manuel Pedro" "apellidos" => "Magalhães" ] 3 => array:2 [ "nombre" => "Maria Ana Sampaio" "apellidos" => "Nunes" ] 4 => array:2 [ "nombre" => "Gilberto" "apellidos" => "Leon" ] 5 => array:2 [ "nombre" => "Manuel" "apellidos" => "Ferreira" ] 6 => array:2 [ "nombre" => "António Pedro" "apellidos" => "Filipe Júnior" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115002115?idApp=UINPBA00004E" "url" => "/08702551/0000003400000010/v1_201510211302/S0870255115002115/v1_201510211302/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "Psoriasis strikes back! Epicardial adipose tissue: Another contributor to the higher cardiovascular risk in psoriasis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "613" "paginaFinal" => "616" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Inês Raposo, Tiago Torres" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Inês" "apellidos" => "Raposo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Tiago" "apellidos" => "Torres" "email" => array:1 [ 0 => "torres.tiago@outlook.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Dermatology, Centro Hospitalar do Porto, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unit for Multidisciplinary Research in Biomedicine, Instituto Ciências Biomédicas Abel Salazar, University of Porto, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Psoríase contra-ataca! Gordura epicárdica: outro importante contribuidor para o aumento do risco de doença cardiovascular na psoríase" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A long time ago, in a Medicine far, far away, psoriasis was considered an inflammatory condition restricted to the skin. With increasing knowledge of the immunopathogenesis of psoriasis, it became clear that the disease's inflammatory action went beyond the skin, affecting the individual systemically. A new view of psoriasis was then formulated: the condition formerly viewed as exclusively dermatologic is now considered an immune-mediated, systemic inflammatory disease associated with numerous medical comorbidities.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> Patients with psoriasis present an increased prevalence of cardiometabolic diseases and overall cardiovascular mortality,<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a> and epidemiologic studies have demonstrated higher prevalence and incidence of cardiovascular risk factors, such as diabetes, dyslipidemia, hypertension and obesity, in these patients.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> However, these factors are not on their own sufficient to explain the increased risk of cardiovascular disease in psoriasis. The inflammatory pathophysiology of atherosclerosis is mechanistically similar to psoriasis, as atherosclerosis and psoriasis share several cytokines and inflammatory mediators.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Various studies have suggested that psoriasis may be an independent risk factor for atherosclerosis, due to the disease's inflammatory burden, showing that psoriasis itself poses an intrinsic risk for cardiovascular disease.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">However, just when it was thought that the association between psoriasis and cardiovascular disease was explained, psoriasis has produced a surprise once again. It appears that causes other than systemic inflammation and traditional cardiovascular risk factors may be implicated in cardiovascular disease in psoriasis.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Epicardial adipose tissue (EAT), a subtype of visceral adipose tissue located between the epicardial layer surrounding the heart and the myocardium, has gained recent clinical attention. EAT is currently considered an active metabolic and inflammatory tissue, with the ability to produce and release various proatherosclerotic and proinflammatory hormones and cytokines, including IL-1 beta, IL-6, TNF-alpha, leptin, plasminogen activator inhibitor-1, and monocyte chemoattractant protein-1.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Its close relation to the coronary tree has been suggested as potentially relevant for the development of coronary artery disease (CAD) by endocrine mechanisms, and particularly by local inflammation and paracrine mechanisms. EAT has been independently associated with CAD, and in the Multi-Ethnic Study of Atherosclerosis it was shown to be predictive of incident cardiovascular events independently of conventional risk factors and body mass index.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Moreover, EAT has been implicated in the development of insulin resistance, diabetes and metabolic syndrome.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Recently, using imaging methods such as transthoracic echocardiography and multidetector computed tomography, EAT has been shown to be increased in psoriatic patients and to be associated with subclinical atherosclerosis, providing another possible link between psoriasis and atherosclerosis.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9–12</span></a> Interestingly, in one study with 100 severe psoriasis patients and 202 controls, EAT volume was found to be increased in psoriatic patients independently of abdominal visceral fat, a reliable marker of excess visceral adiposity, indicating that there may be some psoriasis-related mechanisms contributing to this increased EAT volume.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The reason for the increase in EAT in patients with psoriasis is unknown, but it is probably the result of multifactorial interaction. The association may be partly explained at a genetic level, due to shared genetic and immune-mediated mechanisms. It has recently been shown that psoriasis patients carrying the minor allele (G) of the IL-6 rs2069840 (C>G) polymorphism have increased EAT volume independently of age, gender and abdominal visceral fat. This effect appeared to be enhanced in homozygosity for the G allele (GG), as these patients had increased EAT volume compared to those carrying the C allele (CC+CG).<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> The mechanisms by which IL-6 gene polymorphisms influence EAT or overall adiposity are unknown. It is possible that some IL-6 genotypes are associated with lower energy expenditure, providing a possible explanation for an association between certain polymorphisms and long-term weight gain and obesity.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> If the G allele of the IL-6 rs2069840 polymorphism is associated with lower energy expenditure, these subjects might be expected to have more adiposity for the same level of physical activity and calories ingested compared with persons without the G allele. Additionally, there is increasing evidence for the influence of proinflammatory cytokines, particularly IL-6, on excess adiposity.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> IL-6 has been shown to have a role in the pathogenesis of psoriasis, as it is involved in the immunologic cascade that leads to the disease, including the development of Th17 cells from naïve T cells, and the IL-23-induced skin inflammation that cannot occur without its presence.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> It also has a biologic role in the modulation of body fat and obesity, being secreted by adipose tissue, and is involved in atherogenesis.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Thus, polymorphisms associated with higher expression of IL-6 may partly explain the association between psoriasis and increased EAT volume. Although the IL-6 rs2069840 polymorphism has not been extensively studied, it has been shown to be associated with higher IL-6 plasma levels.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">On the other hand, the reason for increased EAT independently of overall adiposity may be more difficult to explain. However, a recent study showed that epicardial adipocytes differ substantially from visceral adipocytes, expressing higher levels of IL-6 (8.13-fold, p<0.05) and IL-8 (3.25-fold, p<0.05) and lower levels of the atheroprotective adiponectin compared with visceral preadipocytes.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Thus, it is possible that certain gene polymorphisms present in patients with psoriasis may be associated with localized increases in adipose tissue.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Finally, another possible cause is behavioral. Aerobic exercise training has been shown to be associated with significant reductions in EAT thickness. Psoriatic patients exhibit decreased levels of physical activity, possibly for both psychological and physiological reasons, as the stigmatization and social avoidance usually seen in patients with psoriasis might make adherence to physical activity problematic.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Regarding the clinical applications of these findings, EAT measurement may be used as a simple marker to identify psoriatic patients with higher cardiovascular risk. There are several imaging modalities for measuring EAT.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> Although magnetic resonance imaging and computed tomography are currently considered gold standard, echocardiographic measurement of EAT is feasible, reproducible and less expensive and may be a simple and practical tool in clinical practice and research for cardiovascular risk stratification of psoriatic patients.</p><p id="par0045" class="elsevierStylePara elsevierViewall">To summarize, epidemiologic studies have demonstrated that morbidity and mortality in psoriasis are mainly due to cardiovascular disease. Current evidence indicates that along with the increased prevalence of cardiometabolic risk factors and systemic inflammation in psoriasis, EAT is probably another important contributor to the higher cardiovascular risk observed in these patients, with particular importance due to the local effect on the myocardial vasculature. For this reason, it can be said that EAT may be another “Death Star” in psoriasis.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Ethical disclosures</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Protection of human and animal subjects</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Confidentiality of data</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Right to privacy and informed consent</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:7 [ 0 => array:3 [ "identificador" => "xres572373" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec589454" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres572374" "titulo" => "Resumo" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec589455" "titulo" => "Palavras-chave" ] 4 => array:3 [ "identificador" => "sec0005" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0010" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0015" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0020" "titulo" => "Right to privacy and informed consent" ] ] ] 5 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflicts of interest" ] 6 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-03-20" "fechaAceptado" => "2015-04-08" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec589454" "palabras" => array:5 [ 0 => "Atherosclerosis" 1 => "Cardiovascular disease" 2 => "Cardiovascular risk" 3 => "Epicardial adipose tissue" 4 => "Psoriasis" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec589455" "palabras" => array:6 [ 0 => "Aterosclerose" 1 => "Doença cardiovascular" 2 => "Gordura epicárdica" 3 => "Psoríase" 4 => "Risco cardiovascular" 5 => "Tecido adiposo epicárdico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">For many years psoriasis was considered an inflammatory condition restricted to the skin. However, nowadays it is considered an immune-mediated, systemic inflammatory condition associated with numerous medical comorbidities, particularly cardiometabolic diseases, and overall cardiovascular mortality. Several studies have suggested that psoriasis may be an independent risk factor for atherosclerosis, indicating that psoriasis itself poses an intrinsic risk for cardiovascular disease, probably due to the disease's inflammatory burden. However, other causes beyond systemic inflammation and traditional cardiovascular risk factors may be implicated in cardiovascular disease in psoriasis. Recently, epicardial adipose tissue, an emerging cardiovascular risk factor, has been shown to be increased in psoriasis patients and to be associated with subclinical atherosclerosis, providing another possible link between psoriasis and atherosclerosis. The reason for the increase in epicardial adipose tissue in patients with psoriasis is unknown, but it is probably multifactorial, with genetic, immune-mediated and behavioral factors having a role.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Thus, along with the increased prevalence of cardiometabolic risk factors and systemic inflammation in psoriasis, epicardial adipose tissue is probably another important contributor to the higher cardiovascular risk observed in psoriasis.</p></span>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A psoríase foi considerada durante muitos anos uma doença inflamatória exclusivamente cutânea. No entanto, hoje em dia, a psoríase é considerada uma doença inflamatória sistémica, imuno-mediada, associada a diversas comorbilidades, em particular cardiometabólicas, e a um aumento da mortalidade cardiovascular. Vários estudos apontam que a psoríase, por si só, apresenta um risco intrínseco de doença cardiovascular, provavelmente relacionado com a inflamação sistémica, representando um fator de risco independente de aterosclerose. Contudo, outras causas para além da inflamação sistémica e dos fatores de risco cardiovasculares tradicionais poderão estar implicados no desenvolvimento de doença cardiovascular na psoríase. Recentemente, a gordura epicárdica, demonstrou estar aumentada em doentes com psoríase, e associar-se a aterosclerose subclínica, providenciando outra possível explicação para a ligação entre a psoríase e aterosclerose. A razão pela qual a gordura epicárdica se encontra aumentada em doentes com psoríase é ainda desconhecida, mas será provavelmente multifatorial, com fatores genéticos, imunológicos, e comportamentais a desempenharem um papel.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Assim, juntamente com o aumento da prevalência de fatores de risco cardiovasculares tradicionais e a inflamação sistémica psoriática, a gordura epicárdica é provavelmente outro importante contribuidor para o maior risco cardiovascular observado nos doentes com psoríase.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The concept of psoriasis as a systemic inflammation: implications for disease management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K. Reich" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2011.04410.x" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2012" "volumen" => "26" "paginaInicial" => "3" "paginaFinal" => "11" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22356630" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis: the visible killer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Torres" 1 => "N. Bettencourt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.repc.2013.06.017" "Revista" => array:6 [ "tituloSerie" => "Rev Port Cardiol" "fecha" => "2014" "volumen" => "33" "paginaInicial" => "95" "paginaFinal" => "99" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24525359" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N.N. Mehta" 1 => "R.S. Azfar" 2 => "D.B. Shin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehp567" "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2010" "volumen" => "31" "paginaInicial" => "1000" "paginaFinal" => "1006" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20037179" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Meta-analysis of psoriasis, cardiovascular disease, and associated risk factors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "I.M. Miller" 1 => "C. Ellervik" 2 => "S. Yazdanyar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2013.06.053" "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2013" "volumen" => "69" "paginaInicial" => "1014" "paginaFinal" => "1024" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24238156" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109711048315" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis and major adverse cardiovascular events: a systematic review and meta-analysis of observational studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.J. Armstrong" 1 => "C.T. Harskamp" 2 => "A.W. Armstrong" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/JAHA.113.000062" "Revista" => array:5 [ "tituloSerie" => "J Am Heart Assoc" "fecha" => "2013" "volumen" => "2" "paginaInicial" => "e000062" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23557749" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human epicardial adipose tissue: a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H.S. Sacks" 1 => "J.N. Fain" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ahj.2007.03.019" "Revista" => array:6 [ "tituloSerie" => "Am Heart J" "fecha" => "2007" "volumen" => "153" "paginaInicial" => "907" "paginaFinal" => "917" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17540190" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Ding" 1 => "F.C. Hsu" 2 => "T.B. Harris" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3945/ajcn.2008.27358" "Revista" => array:7 [ "tituloSerie" => "Am J Clin Nutr" "fecha" => "2009" "volumen" => "90" "paginaInicial" => "499" "paginaFinal" => "504" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19571212" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109710047170" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epicardial adipose tissue and insulin resistance in obese subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Iacobellis" 1 => "F. Leonetti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jc.2005-1087" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2005" "volumen" => "90" "paginaInicial" => "6300" "paginaFinal" => "6302" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16091479" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epicardial adipose tissue and coronary artery calcification in psoriasis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "T. Torres" 1 => "N. Bettencourt" 2 => "D. Mendonca" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.12516" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2015" "volumen" => "29" "paginaInicial" => "270" "paginaFinal" => "277" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24750319" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patients with psoriasis have an increased amount of epicardial fat tissue" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Balci" 1 => "M. Celik" 2 => "D.D. Balci" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ced.12216" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2014" "volumen" => "39" "paginaInicial" => "123" "paginaFinal" => "128" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24164295" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epicardial fat thickness is independently associated with psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "Z.I. Akyildiz" 1 => "S. Seremet" 2 => "V. Emren" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000354726" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2014" "volumen" => "228" "paginaInicial" => "55" "paginaFinal" => "59" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24158189" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased epicardial fat tissue is a marker of subclinical atherosclerosis in patients with psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B. Bulbul Sen" 1 => "N. Atci" 2 => "E.N. Rifaioglu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.12569" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2013" "volumen" => "169" "paginaInicial" => "1081" "paginaFinal" => "1086" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23909282" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of interleukin-6 gene polymorphisms in epicardial adipose tissue and coronary artery calcification in patients with psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "T. Torres" 1 => "N. Bettencourt" 2 => "J. Ferreira" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.13271" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2015" "volumen" => "172" "paginaInicial" => "534" "paginaFinal" => "536" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25040543" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Qi" 1 => "C. Zhang" 2 => "R.M. van Dam" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jc.2007-0877" "Revista" => array:7 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2007" "volumen" => "92" "paginaInicial" => "3618" "paginaFinal" => "3625" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17623760" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109707037813" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory proteins are related to total and abdominal adiposity in a healthy adolescent population: the AVENA Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Warnberg" 1 => "E. Nova" 2 => "L.A. Moreno" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Clin Nutr" "fecha" => "2006" "volumen" => "84" "paginaInicial" => "505" "paginaFinal" => "512" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16960163" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IL-23-mediated epidermal hyperplasia is dependent on IL-6" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Lindroos" 1 => "L. Svensson" 2 => "H. Norsgaard" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/jid.2010.432" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2011" "volumen" => "131" "paginaInicial" => "1110" "paginaFinal" => "1118" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21289639" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B. Vozarova" 1 => "C. Weyer" 2 => "K. Hanson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/oby.2001.54" "Revista" => array:6 [ "tituloSerie" => "Obes Res" "fecha" => "2001" "volumen" => "9" "paginaInicial" => "414" "paginaFinal" => "417" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11445664" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.F. Terry" 1 => "V. Loukaci" 2 => "F.R. Green" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1074/jbc.M000379200" "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "2000" "volumen" => "275" "paginaInicial" => "18138" "paginaFinal" => "18144" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10747905" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of gene expression of epicardial and visceral adipocytes with regard to the differentiation stage" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Zdychova" 1 => "I Kralova Lesna" 2 => "J. Maluskova" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neuro Endocrinol Lett" "fecha" => "2012" "volumen" => "33" "paginaInicial" => "93" "paginaFinal" => "97" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23183518" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Levels of physical activity in patients with severe psoriasis: a cross-sectional questionnaire study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "T. Torres" 1 => "J.M. Alexandre" 2 => "D. Mendonca" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s40257-014-0061-0" "Revista" => array:6 [ "tituloSerie" => "Am J Clin Dermatol" "fecha" => "2014" "volumen" => "15" "paginaInicial" => "129" "paginaFinal" => "135" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24464933" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epicardial adipose tissue as new cardio-metabolic risk marker and potential therapeutic target in the metabolic syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Iacobellis" 1 => "A.M. Sharma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Curr Pharmaceut Design" "fecha" => "2007" "volumen" => "13" "paginaInicial" => "2180" "paginaFinal" => "2184" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/08702551/0000003400000010/v1_201510211302/S0870255115002139/v1_201510211302/en/main.assets" "Apartado" => array:4 [ "identificador" => "45101" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Artigo de Revisão" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/08702551/0000003400000010/v1_201510211302/S0870255115002139/v1_201510211302/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115002139?idApp=UINPBA00004E" ]
Ano/Mês | Html | Total | |
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2024 Novembro | 7 | 3 | 10 |
2024 Outubro | 37 | 27 | 64 |
2024 Setembro | 50 | 23 | 73 |
2024 Agosto | 41 | 24 | 65 |
2024 Julho | 34 | 32 | 66 |
2024 Junho | 38 | 19 | 57 |
2024 Maio | 32 | 22 | 54 |
2024 Abril | 37 | 22 | 59 |
2024 Maro | 43 | 23 | 66 |
2024 Fevereiro | 50 | 22 | 72 |
2024 Janeiro | 26 | 24 | 50 |
2023 Dezembro | 31 | 22 | 53 |
2023 Novembro | 28 | 26 | 54 |
2023 Outubro | 26 | 11 | 37 |
2023 Setembro | 25 | 20 | 45 |
2023 Agosto | 34 | 16 | 50 |
2023 Julho | 25 | 7 | 32 |
2023 Junho | 25 | 16 | 41 |
2023 Maio | 47 | 27 | 74 |
2023 Abril | 30 | 2 | 32 |
2023 Maro | 36 | 27 | 63 |
2023 Fevereiro | 39 | 20 | 59 |
2023 Janeiro | 18 | 14 | 32 |
2022 Dezembro | 42 | 22 | 64 |
2022 Novembro | 48 | 29 | 77 |
2022 Outubro | 28 | 18 | 46 |
2022 Setembro | 53 | 29 | 82 |
2022 Agosto | 51 | 26 | 77 |
2022 Julho | 62 | 35 | 97 |
2022 Junho | 59 | 20 | 79 |
2022 Maio | 52 | 24 | 76 |
2022 Abril | 37 | 29 | 66 |
2022 Maro | 35 | 36 | 71 |
2022 Fevereiro | 31 | 27 | 58 |
2022 Janeiro | 29 | 19 | 48 |
2021 Dezembro | 25 | 32 | 57 |
2021 Novembro | 31 | 37 | 68 |
2021 Outubro | 36 | 43 | 79 |
2021 Setembro | 28 | 24 | 52 |
2021 Agosto | 35 | 30 | 65 |
2021 Julho | 28 | 27 | 55 |
2021 Junho | 22 | 23 | 45 |
2021 Maio | 28 | 26 | 54 |
2021 Abril | 35 | 25 | 60 |
2021 Maro | 42 | 12 | 54 |
2021 Fevereiro | 78 | 16 | 94 |
2021 Janeiro | 38 | 12 | 50 |
2020 Dezembro | 23 | 4 | 27 |
2020 Novembro | 39 | 14 | 53 |
2020 Outubro | 38 | 14 | 52 |
2020 Setembro | 60 | 10 | 70 |
2020 Agosto | 42 | 8 | 50 |
2020 Julho | 73 | 15 | 88 |
2020 Junho | 54 | 10 | 64 |
2020 Maio | 56 | 3 | 59 |
2020 Abril | 58 | 8 | 66 |
2020 Maro | 61 | 11 | 72 |
2020 Fevereiro | 111 | 14 | 125 |
2020 Janeiro | 42 | 8 | 50 |
2019 Dezembro | 53 | 11 | 64 |
2019 Novembro | 50 | 7 | 57 |
2019 Outubro | 64 | 9 | 73 |
2019 Setembro | 41 | 11 | 52 |
2019 Agosto | 55 | 12 | 67 |
2019 Julho | 87 | 11 | 98 |
2019 Junho | 71 | 13 | 84 |
2019 Maio | 73 | 8 | 81 |
2019 Abril | 25 | 16 | 41 |
2019 Maro | 85 | 8 | 93 |
2019 Fevereiro | 68 | 16 | 84 |
2019 Janeiro | 64 | 4 | 68 |
2018 Dezembro | 51 | 12 | 63 |
2018 Novembro | 115 | 10 | 125 |
2018 Outubro | 194 | 17 | 211 |
2018 Setembro | 48 | 9 | 57 |
2018 Agosto | 30 | 14 | 44 |
2018 Julho | 16 | 10 | 26 |
2018 Junho | 29 | 8 | 37 |
2018 Maio | 27 | 13 | 40 |
2018 Abril | 23 | 10 | 33 |
2018 Maro | 40 | 5 | 45 |
2018 Fevereiro | 19 | 6 | 25 |
2018 Janeiro | 31 | 5 | 36 |
2017 Dezembro | 46 | 17 | 63 |
2017 Novembro | 35 | 11 | 46 |
2017 Outubro | 21 | 14 | 35 |
2017 Setembro | 32 | 12 | 44 |
2017 Agosto | 27 | 17 | 44 |
2017 Julho | 14 | 11 | 25 |
2017 Junho | 25 | 11 | 36 |
2017 Maio | 22 | 8 | 30 |
2017 Abril | 14 | 4 | 18 |
2017 Maro | 22 | 6 | 28 |
2017 Fevereiro | 13 | 9 | 22 |
2017 Janeiro | 22 | 6 | 28 |
2016 Dezembro | 20 | 5 | 25 |
2016 Novembro | 22 | 4 | 26 |
2016 Outubro | 18 | 14 | 32 |
2016 Setembro | 18 | 11 | 29 |
2016 Agosto | 14 | 2 | 16 |
2016 Julho | 6 | 16 | 22 |
2016 Junho | 8 | 12 | 20 |
2016 Maio | 8 | 0 | 8 |
2016 Abril | 19 | 1 | 20 |
2016 Maro | 31 | 12 | 43 |
2016 Fevereiro | 27 | 23 | 50 |
2016 Janeiro | 26 | 28 | 54 |
2015 Dezembro | 32 | 16 | 48 |
2015 Novembro | 66 | 45 | 111 |
2015 Outubro | 80 | 48 | 128 |