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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A long time ago&#44; in a Medicine far&#44; far away&#44; psoriasis was considered an inflammatory condition restricted to the skin&#46; With increasing knowledge of the immunopathogenesis of psoriasis&#44; it became clear that the disease&#39;s inflammatory action went beyond the skin&#44; affecting the individual systemically&#46; A new view of psoriasis was then formulated&#58; the condition formerly viewed as exclusively dermatologic is now considered an immune-mediated&#44; systemic inflammatory disease associated with numerous medical comorbidities&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Patients with psoriasis present an increased prevalence of cardiometabolic diseases and overall cardiovascular mortality&#44;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> and epidemiologic studies have demonstrated higher prevalence and incidence of cardiovascular risk factors&#44; such as diabetes&#44; dyslipidemia&#44; hypertension and obesity&#44; in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> However&#44; these factors are not on their own sufficient to explain the increased risk of cardiovascular disease in psoriasis&#46; The inflammatory pathophysiology of atherosclerosis is mechanistically similar to psoriasis&#44; as atherosclerosis and psoriasis share several cytokines and inflammatory mediators&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Various studies have suggested that psoriasis may be an independent risk factor for atherosclerosis&#44; due to the disease&#39;s inflammatory burden&#44; showing that psoriasis itself poses an intrinsic risk for cardiovascular disease&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">However&#44; just when it was thought that the association between psoriasis and cardiovascular disease was explained&#44; psoriasis has produced a surprise once again&#46; It appears that causes other than systemic inflammation and traditional cardiovascular risk factors may be implicated in cardiovascular disease in psoriasis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Epicardial adipose tissue &#40;EAT&#41;&#44; a subtype of visceral adipose tissue located between the epicardial layer surrounding the heart and the myocardium&#44; has gained recent clinical attention&#46; EAT is currently considered an active metabolic and inflammatory tissue&#44; with the ability to produce and release various proatherosclerotic and proinflammatory hormones and cytokines&#44; including IL-1 beta&#44; IL-6&#44; TNF-alpha&#44; leptin&#44; plasminogen activator inhibitor-1&#44; and monocyte chemoattractant protein-1&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Its close relation to the coronary tree has been suggested as potentially relevant for the development of coronary artery disease &#40;CAD&#41; by endocrine mechanisms&#44; and particularly by local inflammation and paracrine mechanisms&#46; EAT has been independently associated with CAD&#44; and in the Multi-Ethnic Study of Atherosclerosis it was shown to be predictive of incident cardiovascular events independently of conventional risk factors and body mass index&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Moreover&#44; EAT has been implicated in the development of insulin resistance&#44; diabetes and metabolic syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Recently&#44; using imaging methods such as transthoracic echocardiography and multidetector computed tomography&#44; EAT has been shown to be increased in psoriatic patients and to be associated with subclinical atherosclerosis&#44; providing another possible link between psoriasis and atherosclerosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;12</span></a> Interestingly&#44; in one study with 100 severe psoriasis patients and 202 controls&#44; EAT volume was found to be increased in psoriatic patients independently of abdominal visceral fat&#44; a reliable marker of excess visceral adiposity&#44; indicating that there may be some psoriasis-related mechanisms contributing to this increased EAT volume&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The reason for the increase in EAT in patients with psoriasis is unknown&#44; but it is probably the result of multifactorial interaction&#46; The association may be partly explained at a genetic level&#44; due to shared genetic and immune-mediated mechanisms&#46; It has recently been shown that psoriasis patients carrying the minor allele &#40;G&#41; of the IL-6 rs2069840 &#40;C&#62;G&#41; polymorphism have increased EAT volume independently of age&#44; gender and abdominal visceral fat&#46; This effect appeared to be enhanced in homozygosity for the G allele &#40;GG&#41;&#44; as these patients had increased EAT volume compared to those carrying the C allele &#40;CC&#43;CG&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> The mechanisms by which IL-6 gene polymorphisms influence EAT or overall adiposity are unknown&#46; It is possible that some IL-6 genotypes are associated with lower energy expenditure&#44; providing a possible explanation for an association between certain polymorphisms and long-term weight gain and obesity&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> If the G allele of the IL-6 rs2069840 polymorphism is associated with lower energy expenditure&#44; these subjects might be expected to have more adiposity for the same level of physical activity and calories ingested compared with persons without the G allele&#46; Additionally&#44; there is increasing evidence for the influence of proinflammatory cytokines&#44; particularly IL-6&#44; on excess adiposity&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> IL-6 has been shown to have a role in the pathogenesis of psoriasis&#44; as it is involved in the immunologic cascade that leads to the disease&#44; including the development of Th17 cells from na&#239;ve T cells&#44; and the IL-23-induced skin inflammation that cannot occur without its presence&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> It also has a biologic role in the modulation of body fat and obesity&#44; being secreted by adipose tissue&#44; and is involved in atherogenesis&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Thus&#44; polymorphisms associated with higher expression of IL-6 may partly explain the association between psoriasis and increased EAT volume&#46; Although the IL-6 rs2069840 polymorphism has not been extensively studied&#44; it has been shown to be associated with higher IL-6 plasma levels&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">On the other hand&#44; the reason for increased EAT independently of overall adiposity may be more difficult to explain&#46; However&#44; a recent study showed that epicardial adipocytes differ substantially from visceral adipocytes&#44; expressing higher levels of IL-6 &#40;8&#46;13-fold&#44; p&#60;0&#46;05&#41; and IL-8 &#40;3&#46;25-fold&#44; p&#60;0&#46;05&#41; and lower levels of the atheroprotective adiponectin compared with visceral preadipocytes&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Thus&#44; it is possible that certain gene polymorphisms present in patients with psoriasis may be associated with localized increases in adipose tissue&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Finally&#44; another possible cause is behavioral&#46; Aerobic exercise training has been shown to be associated with significant reductions in EAT thickness&#46; Psoriatic patients exhibit decreased levels of physical activity&#44; possibly for both psychological and physiological reasons&#44; as the stigmatization and social avoidance usually seen in patients with psoriasis might make adherence to physical activity problematic&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Regarding the clinical applications of these findings&#44; EAT measurement may be used as a simple marker to identify psoriatic patients with higher cardiovascular risk&#46; There are several imaging modalities for measuring EAT&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> Although magnetic resonance imaging and computed tomography are currently considered gold standard&#44; echocardiographic measurement of EAT is feasible&#44; reproducible and less expensive and may be a simple and practical tool in clinical practice and research for cardiovascular risk stratification of psoriatic patients&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">To summarize&#44; epidemiologic studies have demonstrated that morbidity and mortality in psoriasis are mainly due to cardiovascular disease&#46; Current evidence indicates that along with the increased prevalence of cardiometabolic risk factors and systemic inflammation in psoriasis&#44; EAT is probably another important contributor to the higher cardiovascular risk observed in these patients&#44; with particular importance due to the local effect on the myocardial vasculature&#46; For this reason&#44; it can be said that EAT may be another &#8220;Death Star&#8221; in psoriasis&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Ethical disclosures</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Protection of human and animal subjects</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Confidentiality of data</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Right to privacy and informed consent</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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            5 => "Tecido adiposo epic&#225;rdico"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">For many years psoriasis was considered an inflammatory condition restricted to the skin&#46; However&#44; nowadays it is considered an immune-mediated&#44; systemic inflammatory condition associated with numerous medical comorbidities&#44; particularly cardiometabolic diseases&#44; and overall cardiovascular mortality&#46; Several studies have suggested that psoriasis may be an independent risk factor for atherosclerosis&#44; indicating that psoriasis itself poses an intrinsic risk for cardiovascular disease&#44; probably due to the disease&#39;s inflammatory burden&#46; However&#44; other causes beyond systemic inflammation and traditional cardiovascular risk factors may be implicated in cardiovascular disease in psoriasis&#46; Recently&#44; epicardial adipose tissue&#44; an emerging cardiovascular risk factor&#44; has been shown to be increased in psoriasis patients and to be associated with subclinical atherosclerosis&#44; providing another possible link between psoriasis and atherosclerosis&#46; The reason for the increase in epicardial adipose tissue in patients with psoriasis is unknown&#44; but it is probably multifactorial&#44; with genetic&#44; immune-mediated and behavioral factors having a role&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Thus&#44; along with the increased prevalence of cardiometabolic risk factors and systemic inflammation in psoriasis&#44; epicardial adipose tissue is probably another important contributor to the higher cardiovascular risk observed in psoriasis&#46;</p></span>"
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      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A psor&#237;ase foi considerada durante muitos anos uma doen&#231;a inflamat&#243;ria exclusivamente cut&#226;nea&#46; No entanto&#44; hoje em dia&#44; a psor&#237;ase &#233; considerada uma doen&#231;a inflamat&#243;ria sist&#233;mica&#44; imuno-mediada&#44; associada a diversas comorbilidades&#44; em particular cardiometab&#243;licas&#44; e a um aumento da mortalidade cardiovascular&#46; V&#225;rios estudos apontam que a psor&#237;ase&#44; por si s&#243;&#44; apresenta um risco intr&#237;nseco de doen&#231;a cardiovascular&#44; provavelmente relacionado com a inflama&#231;&#227;o sist&#233;mica&#44; representando um fator de risco independente de aterosclerose&#46; Contudo&#44; outras causas para al&#233;m da inflama&#231;&#227;o sist&#233;mica e dos fatores de risco cardiovasculares tradicionais poder&#227;o estar implicados no desenvolvimento de doen&#231;a cardiovascular na psor&#237;ase&#46; Recentemente&#44; a gordura epic&#225;rdica&#44; demonstrou estar aumentada em doentes com psor&#237;ase&#44; e associar-se a aterosclerose subcl&#237;nica&#44; providenciando outra poss&#237;vel explica&#231;&#227;o para a liga&#231;&#227;o entre a psor&#237;ase e aterosclerose&#46; A raz&#227;o pela qual a gordura epic&#225;rdica se encontra aumentada em doentes com psor&#237;ase &#233; ainda desconhecida&#44; mas ser&#225; provavelmente multifatorial&#44; com fatores gen&#233;ticos&#44; imunol&#243;gicos&#44; e comportamentais a desempenharem um papel&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Assim&#44; juntamente com o aumento da preval&#234;ncia de fatores de risco cardiovasculares tradicionais e a inflama&#231;&#227;o sist&#233;mica psori&#225;tica&#44; a gordura epic&#225;rdica &#233; provavelmente outro importante contribuidor para o maior risco cardiovascular observado nos doentes com psor&#237;ase&#46;</p></span>"
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Review article
Psoriasis strikes back! Epicardial adipose tissue: Another contributor to the higher cardiovascular risk in psoriasis
Psoríase contra-ataca! Gordura epicárdica: outro importante contribuidor para o aumento do risco de doença cardiovascular na psoríase
Inês Raposoa, Tiago Torresa,b,
Autor para correspondência
torres.tiago@outlook.com

Corresponding author.
a Department of Dermatology, Centro Hospitalar do Porto, Portugal
b Unit for Multidisciplinary Research in Biomedicine, Instituto Ciências Biomédicas Abel Salazar, University of Porto, Portugal
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A long time ago&#44; in a Medicine far&#44; far away&#44; psoriasis was considered an inflammatory condition restricted to the skin&#46; With increasing knowledge of the immunopathogenesis of psoriasis&#44; it became clear that the disease&#39;s inflammatory action went beyond the skin&#44; affecting the individual systemically&#46; A new view of psoriasis was then formulated&#58; the condition formerly viewed as exclusively dermatologic is now considered an immune-mediated&#44; systemic inflammatory disease associated with numerous medical comorbidities&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Patients with psoriasis present an increased prevalence of cardiometabolic diseases and overall cardiovascular mortality&#44;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> and epidemiologic studies have demonstrated higher prevalence and incidence of cardiovascular risk factors&#44; such as diabetes&#44; dyslipidemia&#44; hypertension and obesity&#44; in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> However&#44; these factors are not on their own sufficient to explain the increased risk of cardiovascular disease in psoriasis&#46; The inflammatory pathophysiology of atherosclerosis is mechanistically similar to psoriasis&#44; as atherosclerosis and psoriasis share several cytokines and inflammatory mediators&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Various studies have suggested that psoriasis may be an independent risk factor for atherosclerosis&#44; due to the disease&#39;s inflammatory burden&#44; showing that psoriasis itself poses an intrinsic risk for cardiovascular disease&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">However&#44; just when it was thought that the association between psoriasis and cardiovascular disease was explained&#44; psoriasis has produced a surprise once again&#46; It appears that causes other than systemic inflammation and traditional cardiovascular risk factors may be implicated in cardiovascular disease in psoriasis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Epicardial adipose tissue &#40;EAT&#41;&#44; a subtype of visceral adipose tissue located between the epicardial layer surrounding the heart and the myocardium&#44; has gained recent clinical attention&#46; EAT is currently considered an active metabolic and inflammatory tissue&#44; with the ability to produce and release various proatherosclerotic and proinflammatory hormones and cytokines&#44; including IL-1 beta&#44; IL-6&#44; TNF-alpha&#44; leptin&#44; plasminogen activator inhibitor-1&#44; and monocyte chemoattractant protein-1&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Its close relation to the coronary tree has been suggested as potentially relevant for the development of coronary artery disease &#40;CAD&#41; by endocrine mechanisms&#44; and particularly by local inflammation and paracrine mechanisms&#46; EAT has been independently associated with CAD&#44; and in the Multi-Ethnic Study of Atherosclerosis it was shown to be predictive of incident cardiovascular events independently of conventional risk factors and body mass index&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Moreover&#44; EAT has been implicated in the development of insulin resistance&#44; diabetes and metabolic syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Recently&#44; using imaging methods such as transthoracic echocardiography and multidetector computed tomography&#44; EAT has been shown to be increased in psoriatic patients and to be associated with subclinical atherosclerosis&#44; providing another possible link between psoriasis and atherosclerosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;12</span></a> Interestingly&#44; in one study with 100 severe psoriasis patients and 202 controls&#44; EAT volume was found to be increased in psoriatic patients independently of abdominal visceral fat&#44; a reliable marker of excess visceral adiposity&#44; indicating that there may be some psoriasis-related mechanisms contributing to this increased EAT volume&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The reason for the increase in EAT in patients with psoriasis is unknown&#44; but it is probably the result of multifactorial interaction&#46; The association may be partly explained at a genetic level&#44; due to shared genetic and immune-mediated mechanisms&#46; It has recently been shown that psoriasis patients carrying the minor allele &#40;G&#41; of the IL-6 rs2069840 &#40;C&#62;G&#41; polymorphism have increased EAT volume independently of age&#44; gender and abdominal visceral fat&#46; This effect appeared to be enhanced in homozygosity for the G allele &#40;GG&#41;&#44; as these patients had increased EAT volume compared to those carrying the C allele &#40;CC&#43;CG&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> The mechanisms by which IL-6 gene polymorphisms influence EAT or overall adiposity are unknown&#46; It is possible that some IL-6 genotypes are associated with lower energy expenditure&#44; providing a possible explanation for an association between certain polymorphisms and long-term weight gain and obesity&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> If the G allele of the IL-6 rs2069840 polymorphism is associated with lower energy expenditure&#44; these subjects might be expected to have more adiposity for the same level of physical activity and calories ingested compared with persons without the G allele&#46; Additionally&#44; there is increasing evidence for the influence of proinflammatory cytokines&#44; particularly IL-6&#44; on excess adiposity&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> IL-6 has been shown to have a role in the pathogenesis of psoriasis&#44; as it is involved in the immunologic cascade that leads to the disease&#44; including the development of Th17 cells from na&#239;ve T cells&#44; and the IL-23-induced skin inflammation that cannot occur without its presence&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> It also has a biologic role in the modulation of body fat and obesity&#44; being secreted by adipose tissue&#44; and is involved in atherogenesis&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Thus&#44; polymorphisms associated with higher expression of IL-6 may partly explain the association between psoriasis and increased EAT volume&#46; Although the IL-6 rs2069840 polymorphism has not been extensively studied&#44; it has been shown to be associated with higher IL-6 plasma levels&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">On the other hand&#44; the reason for increased EAT independently of overall adiposity may be more difficult to explain&#46; However&#44; a recent study showed that epicardial adipocytes differ substantially from visceral adipocytes&#44; expressing higher levels of IL-6 &#40;8&#46;13-fold&#44; p&#60;0&#46;05&#41; and IL-8 &#40;3&#46;25-fold&#44; p&#60;0&#46;05&#41; and lower levels of the atheroprotective adiponectin compared with visceral preadipocytes&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Thus&#44; it is possible that certain gene polymorphisms present in patients with psoriasis may be associated with localized increases in adipose tissue&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Finally&#44; another possible cause is behavioral&#46; Aerobic exercise training has been shown to be associated with significant reductions in EAT thickness&#46; Psoriatic patients exhibit decreased levels of physical activity&#44; possibly for both psychological and physiological reasons&#44; as the stigmatization and social avoidance usually seen in patients with psoriasis might make adherence to physical activity problematic&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Regarding the clinical applications of these findings&#44; EAT measurement may be used as a simple marker to identify psoriatic patients with higher cardiovascular risk&#46; There are several imaging modalities for measuring EAT&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> Although magnetic resonance imaging and computed tomography are currently considered gold standard&#44; echocardiographic measurement of EAT is feasible&#44; reproducible and less expensive and may be a simple and practical tool in clinical practice and research for cardiovascular risk stratification of psoriatic patients&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">To summarize&#44; epidemiologic studies have demonstrated that morbidity and mortality in psoriasis are mainly due to cardiovascular disease&#46; Current evidence indicates that along with the increased prevalence of cardiometabolic risk factors and systemic inflammation in psoriasis&#44; EAT is probably another important contributor to the higher cardiovascular risk observed in these patients&#44; with particular importance due to the local effect on the myocardial vasculature&#46; For this reason&#44; it can be said that EAT may be another &#8220;Death Star&#8221; in psoriasis&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Ethical disclosures</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Protection of human and animal subjects</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Confidentiality of data</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Right to privacy and informed consent</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">For many years psoriasis was considered an inflammatory condition restricted to the skin&#46; However&#44; nowadays it is considered an immune-mediated&#44; systemic inflammatory condition associated with numerous medical comorbidities&#44; particularly cardiometabolic diseases&#44; and overall cardiovascular mortality&#46; Several studies have suggested that psoriasis may be an independent risk factor for atherosclerosis&#44; indicating that psoriasis itself poses an intrinsic risk for cardiovascular disease&#44; probably due to the disease&#39;s inflammatory burden&#46; However&#44; other causes beyond systemic inflammation and traditional cardiovascular risk factors may be implicated in cardiovascular disease in psoriasis&#46; Recently&#44; epicardial adipose tissue&#44; an emerging cardiovascular risk factor&#44; has been shown to be increased in psoriasis patients and to be associated with subclinical atherosclerosis&#44; providing another possible link between psoriasis and atherosclerosis&#46; The reason for the increase in epicardial adipose tissue in patients with psoriasis is unknown&#44; but it is probably multifactorial&#44; with genetic&#44; immune-mediated and behavioral factors having a role&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Thus&#44; along with the increased prevalence of cardiometabolic risk factors and systemic inflammation in psoriasis&#44; epicardial adipose tissue is probably another important contributor to the higher cardiovascular risk observed in psoriasis&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A psor&#237;ase foi considerada durante muitos anos uma doen&#231;a inflamat&#243;ria exclusivamente cut&#226;nea&#46; No entanto&#44; hoje em dia&#44; a psor&#237;ase &#233; considerada uma doen&#231;a inflamat&#243;ria sist&#233;mica&#44; imuno-mediada&#44; associada a diversas comorbilidades&#44; em particular cardiometab&#243;licas&#44; e a um aumento da mortalidade cardiovascular&#46; V&#225;rios estudos apontam que a psor&#237;ase&#44; por si s&#243;&#44; apresenta um risco intr&#237;nseco de doen&#231;a cardiovascular&#44; provavelmente relacionado com a inflama&#231;&#227;o sist&#233;mica&#44; representando um fator de risco independente de aterosclerose&#46; Contudo&#44; outras causas para al&#233;m da inflama&#231;&#227;o sist&#233;mica e dos fatores de risco cardiovasculares tradicionais poder&#227;o estar implicados no desenvolvimento de doen&#231;a cardiovascular na psor&#237;ase&#46; Recentemente&#44; a gordura epic&#225;rdica&#44; demonstrou estar aumentada em doentes com psor&#237;ase&#44; e associar-se a aterosclerose subcl&#237;nica&#44; providenciando outra poss&#237;vel explica&#231;&#227;o para a liga&#231;&#227;o entre a psor&#237;ase e aterosclerose&#46; A raz&#227;o pela qual a gordura epic&#225;rdica se encontra aumentada em doentes com psor&#237;ase &#233; ainda desconhecida&#44; mas ser&#225; provavelmente multifatorial&#44; com fatores gen&#233;ticos&#44; imunol&#243;gicos&#44; e comportamentais a desempenharem um papel&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Assim&#44; juntamente com o aumento da preval&#234;ncia de fatores de risco cardiovasculares tradicionais e a inflama&#231;&#227;o sist&#233;mica psori&#225;tica&#44; a gordura epic&#225;rdica &#233; provavelmente outro importante contribuidor para o maior risco cardiovascular observado nos doentes com psor&#237;ase&#46;</p></span>"
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