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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case report</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 73-year-old woman with a history of systemic lupus erythematosus &#40;SLE&#41; diagnosed 15 years ago&#44; treated with corticosteroids and hydroxychloroquine&#44; presented to an ophthalmology consultation after a three-hour period of sudden and marked decreased right visual acuity&#46; No other symptoms were reported&#44; including fever or localized weakness&#46; Fundoscopic examination showed a pale retina with a cherry-red macula &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41; and a diagnosis of right central retinal artery occlusion was made&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Transthoracic and transesophageal echocardiography revealed the presence of a mass attached to the ventricular side of the posterior mitral leaflet&#44; with a vibratory motion&#44; a maximum diameter of 13 mm&#44; irregular shape and heterogeneous echogenicity&#44; consistent with vegetation &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#46; The aortic valve had thickened leaflets &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41; and moderate regurgitation by color Doppler&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Carotid Doppler ultrasound showed no significant atherosclerotic lesions and no other cardioembolic sources were detected&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Inflammatory parameters &#40;white blood cell count 6&#46;9<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;l&#44; C-reactive protein 1&#46;6 mg&#47;dl and erythrocyte sedimentation rate 44 mm&#47;h&#41; were not suggestive of infection&#46; Blood cultures were negative&#46; Autoimmunity study revealed antinuclear antibodies positive at a titer of 1&#47;320&#44; with no other positive antibodies&#44; including negative antiphospholipid antibodies &#40;APA&#41;&#46; C3 and C4 levels were normal&#46; Thrombophilia tests including C and S protein levels&#44; antithrombin III and resistance to activated protein C were also normal&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We assumed a diagnosis of Libman-Sacks endocarditis &#40;LSE&#41; and the patient started anticoagulation therapy&#46; A follow-up transesophageal echocardiogram four weeks later showed resolution of the previously described vegetation&#46; There was no recurrence of thromboembolic events&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">SLE is an autoimmune disease that causes multiorgan inflammatory damage&#46; In recent decades&#44; with increasing survival and advances in diagnostic techniques&#44; particularly in echocardiography&#44; cardiac disease associated with SLE has become more evident&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Valvular disease is one of the main cardiac manifestations of SLE and can occur in the form of valvular thickening&#44; masses or noninfective vegetations &#40;LSE&#41;&#44; valvular regurgitation and valvular stenosis&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">LSE was first described in 1924 by Libman and Sacks in four patients with SLE and noninfective verrucous vegetations&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Libman-Sacks vegetations develop mainly on the mitral valve&#44; followed by the aortic valve&#44; but may develop on any other valve&#44; on the subvalvular apparatus or on the surface of the endocardium&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> They are usually located on the atrial side of the mitral valve leaflets or the vessel side of the aortic valve leaflets&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">A significant proportion of patients with SLE have LSE detected in autopsy studies &#40;30&#8211;50&#37;&#41;&#46; However&#44; the real prevalence of LSE remains unknown since most patients with Libman-Sacks vegetations have asymptomatic valve abnormalities&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Moyssakis et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> studied 342 patients with SLE by echocardiography over four years and found an 11&#37; incidence of LSE and an association with lupus duration&#44; disease activity&#44; presence of anticardiolipin antibody and manifestations of antiphospholipid syndrome&#46; Roldan et al&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> studied 69 patients with SLE by transesophageal echocardiography and found a 43&#37; incidence of LSE&#44; which may be related to the greater accuracy of this modality&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">It has been proposed that LSE is due to the formation of fibrin-platelet thrombi on the injured valve&#44; followed by tissue organization and leading to valvular fibrosis&#44; distortion and subsequent dysfunction&#46; Recent studies have shown deposition of immunoglobulins and complement in the valvular structure which subsequently developed LSE and valvular thickening&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The association of LSE and APA has been widely investigated and has been reported in several studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#44;5</span></a> although others have found no connection&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The role of APA in the pathogenesis of valvular disease is thought to be by promoting thrombus formation on injured valve endothelium and inflammatory changes&#44; rather than a more direct pathogenic role&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Further&#44; the observation that there is a significantly higher prevalence of valvular lesions in patients with antiphospholipid syndrome &#40;APS&#41; secondary to SLE than in those with primary APS may mean that there are SLE-related factors that promote endocardial damage and contribute to this difference&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a> APA were not detected in our patient&#44; which is in agreement with this theory&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">One recognized complication of LSE is the development of secondary infectious endocarditis<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> which increases the complexity of differential diagnosis in a patient with SLE who presents with a valve mass&#46; Infective endocarditis lesions are usually located at the leaflet&#39;s line of closure&#44; are homogeneous in echogenicity and may show a vibratory or rotatory motion&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In contrast&#44; LSE lesions are usually located at the base&#44; middle or tip of the leaflets and are variable in shape and size and heterogeneous in echogenicity&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Thus it is imperative to differentiate between these two clinical identities&#44; since management and treatment are quite different&#46; Our patient had no fever&#44; her leukocyte count was normal and blood cultures were negative&#44; which enabled us to reach a diagnosis of LSE and to initiate anticoagulation therapy&#46; Follow-up transesophageal echocardiography provided an assessment of disease progression&#44; revealing the regression of the previously observed vegetation&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The main clinical impact of LSE is related to the probability of lesion progression to valvular dysfunction and the tendency to thromboembolic events&#44; especially stroke or transient ischemic attack&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#44;4</span></a> The incidence of thromboembolic cerebrovascular events in patients with LSE has been reported as 10&#8211;20&#37;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a> and a cardioembolic origin was assumed in most cases&#46; In our search of the literature we found several case reports of distal embolization from LSE&#44; the majority reporting cerebral embolization&#44; but none with retinal embolization&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In the present case&#44; there was an occlusion of the right central retinal artery&#44; which originates from the ophthalmic artery&#44; the first intracranial branch of the internal carotid artery&#46; Given the temporal relationship between the onset of right blindness and the echocardiographic finding of a mass adhering to the mitral valve&#44; it was assumed that the retinal artery occlusion was cardioembolic in origin&#46; The patient was started on anticoagulation therapy for secondary thromboprophylaxis and remission of the previously detected vegetation was achieved&#46; To date she has had no new thromboembolic events&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">With this case report we highlight the importance of awareness of this entity&#44; 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Case report
Retinal artery embolization complicating Libman-Sacks endocarditis in a systemic lupus erythematosus patient
Endocardite de Libman-Sacks complicada por embolização da artéria da retina num doente com LES
Liliana Martaa,
Autor para correspondência
liliana.marta@gmail.com

Corresponding author.
, Maria Luz Pittaa, Marisa Peresa, Vítor Ferreirab, Maria Clotilde Pugab, Davide Severinoa, Graça Ferreira da Silvaa
a Serviço de Cardiologia, Hospital de Santarém, Santarém, Portugal
b Departamento de Oftalmologia, Hospital de Santarém, Santarém, Portugal
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        "titulo" => "Endocardite de Libman-Sacks complicada por emboliza&#231;&#227;o da art&#233;ria da retina num doente com LES"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case report</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 73-year-old woman with a history of systemic lupus erythematosus &#40;SLE&#41; diagnosed 15 years ago&#44; treated with corticosteroids and hydroxychloroquine&#44; presented to an ophthalmology consultation after a three-hour period of sudden and marked decreased right visual acuity&#46; No other symptoms were reported&#44; including fever or localized weakness&#46; Fundoscopic examination showed a pale retina with a cherry-red macula &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41; and a diagnosis of right central retinal artery occlusion was made&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Transthoracic and transesophageal echocardiography revealed the presence of a mass attached to the ventricular side of the posterior mitral leaflet&#44; with a vibratory motion&#44; a maximum diameter of 13 mm&#44; irregular shape and heterogeneous echogenicity&#44; consistent with vegetation &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#46; The aortic valve had thickened leaflets &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41; and moderate regurgitation by color Doppler&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Carotid Doppler ultrasound showed no significant atherosclerotic lesions and no other cardioembolic sources were detected&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Inflammatory parameters &#40;white blood cell count 6&#46;9<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;l&#44; C-reactive protein 1&#46;6 mg&#47;dl and erythrocyte sedimentation rate 44 mm&#47;h&#41; were not suggestive of infection&#46; Blood cultures were negative&#46; Autoimmunity study revealed antinuclear antibodies positive at a titer of 1&#47;320&#44; with no other positive antibodies&#44; including negative antiphospholipid antibodies &#40;APA&#41;&#46; C3 and C4 levels were normal&#46; Thrombophilia tests including C and S protein levels&#44; antithrombin III and resistance to activated protein C were also normal&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We assumed a diagnosis of Libman-Sacks endocarditis &#40;LSE&#41; and the patient started anticoagulation therapy&#46; A follow-up transesophageal echocardiogram four weeks later showed resolution of the previously described vegetation&#46; There was no recurrence of thromboembolic events&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">SLE is an autoimmune disease that causes multiorgan inflammatory damage&#46; In recent decades&#44; with increasing survival and advances in diagnostic techniques&#44; particularly in echocardiography&#44; cardiac disease associated with SLE has become more evident&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Valvular disease is one of the main cardiac manifestations of SLE and can occur in the form of valvular thickening&#44; masses or noninfective vegetations &#40;LSE&#41;&#44; valvular regurgitation and valvular stenosis&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">LSE was first described in 1924 by Libman and Sacks in four patients with SLE and noninfective verrucous vegetations&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Libman-Sacks vegetations develop mainly on the mitral valve&#44; followed by the aortic valve&#44; but may develop on any other valve&#44; on the subvalvular apparatus or on the surface of the endocardium&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> They are usually located on the atrial side of the mitral valve leaflets or the vessel side of the aortic valve leaflets&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">A significant proportion of patients with SLE have LSE detected in autopsy studies &#40;30&#8211;50&#37;&#41;&#46; However&#44; the real prevalence of LSE remains unknown since most patients with Libman-Sacks vegetations have asymptomatic valve abnormalities&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Moyssakis et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> studied 342 patients with SLE by echocardiography over four years and found an 11&#37; incidence of LSE and an association with lupus duration&#44; disease activity&#44; presence of anticardiolipin antibody and manifestations of antiphospholipid syndrome&#46; Roldan et al&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> studied 69 patients with SLE by transesophageal echocardiography and found a 43&#37; incidence of LSE&#44; which may be related to the greater accuracy of this modality&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">It has been proposed that LSE is due to the formation of fibrin-platelet thrombi on the injured valve&#44; followed by tissue organization and leading to valvular fibrosis&#44; distortion and subsequent dysfunction&#46; Recent studies have shown deposition of immunoglobulins and complement in the valvular structure which subsequently developed LSE and valvular thickening&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The association of LSE and APA has been widely investigated and has been reported in several studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#44;5</span></a> although others have found no connection&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The role of APA in the pathogenesis of valvular disease is thought to be by promoting thrombus formation on injured valve endothelium and inflammatory changes&#44; rather than a more direct pathogenic role&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Further&#44; the observation that there is a significantly higher prevalence of valvular lesions in patients with antiphospholipid syndrome &#40;APS&#41; secondary to SLE than in those with primary APS may mean that there are SLE-related factors that promote endocardial damage and contribute to this difference&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a> APA were not detected in our patient&#44; which is in agreement with this theory&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">One recognized complication of LSE is the development of secondary infectious endocarditis<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> which increases the complexity of differential diagnosis in a patient with SLE who presents with a valve mass&#46; Infective endocarditis lesions are usually located at the leaflet&#39;s line of closure&#44; are homogeneous in echogenicity and may show a vibratory or rotatory motion&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In contrast&#44; LSE lesions are usually located at the base&#44; middle or tip of the leaflets and are variable in shape and size and heterogeneous in echogenicity&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Thus it is imperative to differentiate between these two clinical identities&#44; since management and treatment are quite different&#46; Our patient had no fever&#44; her leukocyte count was normal and blood cultures were negative&#44; which enabled us to reach a diagnosis of LSE and to initiate anticoagulation therapy&#46; Follow-up transesophageal echocardiography provided an assessment of disease progression&#44; revealing the regression of the previously observed vegetation&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The main clinical impact of LSE is related to the probability of lesion progression to valvular dysfunction and the tendency to thromboembolic events&#44; especially stroke or transient ischemic attack&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#44;4</span></a> The incidence of thromboembolic cerebrovascular events in patients with LSE has been reported as 10&#8211;20&#37;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a> and a cardioembolic origin was assumed in most cases&#46; In our search of the literature we found several case reports of distal embolization from LSE&#44; the majority reporting cerebral embolization&#44; but none with retinal embolization&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In the present case&#44; there was an occlusion of the right central retinal artery&#44; which originates from the ophthalmic artery&#44; the first intracranial branch of the internal carotid artery&#46; Given the temporal relationship between the onset of right blindness and the echocardiographic finding of a mass adhering to the mitral valve&#44; it was assumed that the retinal artery occlusion was cardioembolic in origin&#46; The patient was started on anticoagulation therapy for secondary thromboprophylaxis and remission of the previously detected vegetation was achieved&#46; To date she has had no new thromboembolic events&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">With this case report we highlight the importance of awareness of this entity&#44; allowing rapid referral for cardiovascular examination and thus enabling early diagnosis and appropriate intervention&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Given that most patients with SLE and valvular disease have no cardiac symptoms&#44; a careful cardiovascular examination should be made periodically&#46; Since strokes in patients with SLE are frequent and&#44; on the other hand&#44; valvular thickening and vegetations are common and can act as substrates for cardioembolism&#44; prophylactic therapy with anticoagulation may be an appropriate approach to these patients&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Protection of human and animal subjects</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Confidentiality of data</span><p id="par0090" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Right to privacy and informed consent</span><p id="par0095" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Libman-Sacks endocarditis &#40;LSE&#41; is the most characteristic cardiac manifestation of systemic lupus erythematosus &#40;SLE&#41;&#46; It is usually clinically silent but heart failure due to valvular dysfunction&#44; secondary infective endocarditis and embolic phenomena can complicate valvular abnormalities&#46; We present a patient with SLE and blindness due to right central retinal artery occlusion&#46; Echocardiographic examination revealed a verrucous vegetation on the posterior mitral valve leaflet consistent with LSE&#46; Anticoagulation therapy was started&#46; Echocardiographic regression of the vegetation was observed and there has been no recurrence of thromboembolic events to date&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A endocardite de Libman-Sacks &#233; a manifesta&#231;&#227;o card&#237;aca mais caracter&#237;stica do LES&#46; &#201; habitualmente clinicamente silenciosa&#44; mas a insufici&#234;ncia card&#237;aca por disfun&#231;&#227;o valvular&#44; a endocardite infecciosa secund&#225;ria e os fen&#243;menos emb&#243;licos podem complicar as altera&#231;&#245;es valvulares&#46; Apresentamos um caso cl&#237;nico de uma doente com LES e amaurose &#224; direita por trombose da art&#233;ria central da retina&#46; O ecocardiograma mostrou uma vegeta&#231;&#227;o verrucosa no folheto posterior da v&#225;lvula mitral&#44; compat&#237;vel com endocardite de Libman-Sacks&#46; A doente iniciou terap&#234;utica com anticoagula&#231;&#227;o&#44; verificou-se regress&#227;o da vegeta&#231;&#227;o descrita e n&#227;o teve recorr&#234;ncia de eventos tromboemb&#243;licos at&#233; &#224; data&#46;</p>"
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Informação do artigo
ISSN: 08702551
Idioma original: Inglês
Dados atualizados diariamente
Ano/Mês Html Pdf Total
2024 Novembro 16 6 22
2024 Outubro 69 42 111
2024 Setembro 101 35 136
2024 Agosto 89 35 124
2024 Julho 63 34 97
2024 Junho 52 24 76
2024 Maio 69 19 88
2024 Abril 69 35 104
2024 Maro 78 26 104
2024 Fevereiro 82 36 118
2024 Janeiro 62 37 99
2023 Dezembro 53 25 78
2023 Novembro 62 25 87
2023 Outubro 50 19 69
2023 Setembro 63 25 88
2023 Agosto 60 23 83
2023 Julho 84 16 100
2023 Junho 52 14 66
2023 Maio 73 25 98
2023 Abril 66 6 72
2023 Maro 86 30 116
2023 Fevereiro 54 27 81
2023 Janeiro 55 26 81
2022 Dezembro 97 24 121
2022 Novembro 84 25 109
2022 Outubro 112 21 133
2022 Setembro 109 45 154
2022 Agosto 87 26 113
2022 Julho 70 44 114
2022 Junho 49 29 78
2022 Maio 60 37 97
2022 Abril 73 21 94
2022 Maro 50 38 88
2022 Fevereiro 52 22 74
2022 Janeiro 52 23 75
2021 Dezembro 50 35 85
2021 Novembro 65 39 104
2021 Outubro 57 47 104
2021 Setembro 52 35 87
2021 Agosto 54 28 82
2021 Julho 82 27 109
2021 Junho 54 19 73
2021 Maio 57 29 86
2021 Abril 124 38 162
2021 Maro 114 22 136
2021 Fevereiro 101 18 119
2021 Janeiro 67 14 81
2020 Dezembro 42 6 48
2020 Novembro 58 19 77
2020 Outubro 56 24 80
2020 Setembro 90 17 107
2020 Agosto 53 8 61
2020 Julho 72 17 89
2020 Junho 79 16 95
2020 Maio 104 10 114
2020 Abril 57 8 65
2020 Maro 66 11 77
2020 Fevereiro 193 30 223
2020 Janeiro 80 7 87
2019 Dezembro 81 12 93
2019 Novembro 97 8 105
2019 Outubro 118 8 126
2019 Setembro 147 12 159
2019 Agosto 77 4 81
2019 Julho 100 14 114
2019 Junho 94 10 104
2019 Maio 130 12 142
2019 Abril 89 19 108
2019 Maro 162 14 176
2019 Fevereiro 159 15 174
2019 Janeiro 107 6 113
2018 Dezembro 119 10 129
2018 Novembro 127 10 137
2018 Outubro 156 23 179
2018 Setembro 48 12 60
2018 Agosto 51 10 61
2018 Julho 52 6 58
2018 Junho 77 7 84
2018 Maio 79 9 88
2018 Abril 136 19 155
2018 Maro 84 10 94
2018 Fevereiro 58 4 62
2018 Janeiro 54 5 59
2017 Dezembro 106 13 119
2017 Novembro 55 11 66
2017 Outubro 28 9 37
2017 Setembro 58 7 65
2017 Agosto 64 12 76
2017 Julho 36 6 42
2017 Junho 55 16 71
2017 Maio 76 10 86
2017 Abril 53 2 55
2017 Maro 69 15 84
2017 Fevereiro 107 10 117
2017 Janeiro 47 9 56
2016 Dezembro 39 17 56
2016 Novembro 43 23 66
2016 Outubro 57 14 71
2016 Setembro 99 9 108
2016 Agosto 44 6 50
2016 Julho 13 6 19
2016 Junho 5 5 10
2016 Maio 18 0 18
2016 Abril 50 4 54
2016 Maro 97 10 107
2016 Fevereiro 127 21 148
2016 Janeiro 93 12 105
2015 Dezembro 105 12 117
2015 Novembro 98 5 103
2015 Outubro 116 12 128
2015 Setembro 120 13 133
2015 Agosto 115 15 130
2015 Julho 144 6 150
2015 Junho 89 2 91
2015 Maio 76 8 84
2015 Abril 87 7 94
2015 Maro 87 11 98
2015 Fevereiro 129 9 138
2015 Janeiro 90 12 102
2014 Dezembro 80 11 91
2014 Novembro 78 8 86
2014 Outubro 91 17 108
2014 Setembro 76 16 92
2014 Agosto 71 13 84
2014 Julho 59 16 75
2014 Junho 62 16 78
2014 Maio 58 17 75
2014 Abril 67 11 78
2014 Maro 144 15 159
2014 Fevereiro 127 10 137
2014 Janeiro 123 15 138
2013 Dezembro 126 13 139
2013 Novembro 124 12 136
2013 Outubro 103 9 112
2013 Setembro 107 19 126
2013 Agosto 108 21 129
2013 Julho 94 22 116
2013 Junho 73 21 94
2013 Maio 109 38 147
2013 Abril 32 15 47
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