Genetic polymorphisms in apolipoprotein E and atrial fibrillation

Mungmunpuntipantip, Rujittika; Wiwanitkit, Viroj

doi:10.1016/j.repc.2022.09.003

Revista Portuguesa de Cardiologia (English edition)

ISSN: 2174-2049

The Portuguese Journal of Cardiology, the official journal of the Portuguese Society of Cardiology, was founded in 1982 with the aim of keeping Portuguese cardiologists informed through the publication of scientific articles on areas such as arrhythmology and electrophysiology, cardiovascular surgery, intensive care, coronary artery disease, cardiovascular imaging, hypertension, heart failure and cardiovascular prevention. The Journal is a monthly publication with high standards of quality in terms of scientific content and production. Since 1999 it has been published in English as well as Portuguese, which has widened its readership abroad. It is distributed to all members of the Portuguese Societies of Cardiology, Internal Medicine, Pneumology and Cardiothoracic Surgery, as well as to leading non-Portuguese cardiologists and to virtually all cardiology societies worldwide. It has been referred in Medline since 1987.

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Atrial fibrillation (AF) and genetic variations in apolipoprotein E (ApoE) were investigated by Wang et al.1 ApoE4 is an AF-sensitive phenotype, according to Wang et al., who also reported that ApoE polymorphisms had an impact on the occurrence of AF.1 The inherited component may or may not affect AF. In this study, the impact of a polymorphism is examined. We agree that the underlying genetic factor under study might be related to AF, however numerous genetic variants have been linked to AF. Gene polymorphisms in the GJA1, ATFB5, and ADAMTS-13 families are some examples.2–4 Future research should take into account the effects of new, possibly puzzling genetic variations.

Conflict of interest

None declared.

References

[1]

Y. Wang, H. Lou, M. Wang, et al.

Correlation between genetic polymorphisms in apolipoprotein E and atrial fibrillation.

Rev Port Cardiol, 41 (2022), pp. 417-423

http://dx.doi.org/10.1016/j.repc.2021.03.013 | Medline

[2]

S. Okamura, H. Ochi, Y. Onohara, et al.

GJA1 gene polymorphism is a genetic predictor of recurrence following pulmonary vein isolation in patients with paroxysmal atrial fibrillation.

Heart Rhythm, 19 (2022), pp. 2044-2050

http://dx.doi.org/10.1016/j.hrthm.2022.08.024 | Medline

[3]

G. Abdullaeva, A. Abdullaev, A. Kevorkov, et al.

Interrelation between the rs2200733 polymorphism of the ATFB5 gene and atrial fibrillation in Uzbek patients.

Turk Kardiyol Dern Ars, 49 (2021), pp. 404-409

http://dx.doi.org/10.5543/tkda.2021.08434 | Medline

[4]

H.J. Wang, M. Xiao, Z. Zeng, et al.

Correlation analysis between ADAMTS-13 gene polymorphism and hypertension-induced atrial fibrillation.

Eur Rev Med Pharmacol Sci, 24 (2020), pp. 2674-2682

http://dx.doi.org/10.26355/eurrev_202003_20537 | Medline

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