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He denied intravenous drug abuse&#44; diabetes&#44; malignancy or other immunosuppressive conditions&#46; On physical examination he was febrile &#40;axillary temperature 38&#46;4<span class="elsevierStyleHsp" style=""></span>&#176;C&#41;&#44; with blood pressure of 125&#47;78<span class="elsevierStyleHsp" style=""></span>mmHg and heart rate of 118<span class="elsevierStyleHsp" style=""></span>bpm&#46; Cardiovascular assessment showed regular heart rhythm&#44; normal heart sounds and a significant systolic murmur in the mitral focus&#46; The rest of the examination was normal&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Laboratory tests showed slight leukocytosis without eosinophilia&#46; Transthoracic echocardiography revealed an image suggesting vegetations on the biological valve&#44; which was confirmed by transesophageal echocardiography &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46; Blood cultures were taken and empirical antimicrobial therapy was begun&#44; but the patient&#8217;s infection worsened and he developed hemodynamic instability&#46; The mitral bioprosthesis was accordingly replaced by a metal valve&#46; The vegetation adhering to the bioprosthesis was cultured and following macroscopic examination &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41; amphotericin B was added&#46; On the sixth postoperative day growth of <span class="elsevierStyleItalic">T&#46; beigelii</span> was observed in the culture from the bioprosthesis and&#44; in view of clinical deterioration&#44; the antifungal was replaced by voriconazole&#46; However&#44; the patient developed multiorgan failure and died on the 13th day after surgical intervention&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">In the literature&#44; there are only 11 published cases of IE due to <span class="elsevierStyleItalic">T&#46; beigelii&#46;</span><a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;11</span></a> In the nine reports of cases affecting prosthetic valves&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#44;5&#8211;11</span></a> the mean interval between cardiac surgery and the diagnosis of IE was four years&#44; ranging between three months and eight years&#46; The present case is unusual in that 11 years had passed after valve replacement&#44; making this the longest period so far recorded&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">There are no laboratory findings characteristic of trichosporonemia&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a> which often delays diagnosis of this serious condition&#46; Eosinophilia was observed in only four<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5&#44;6&#44;8</span></a> of the 11 reported cases and was not seen in the present case&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Blood cultures are frequently negative in systemic trichosporonosis&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> although they revealed the presence of <span class="elsevierStyleItalic">Trichosporon</span> spp&#46; in seven of the reported cases&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3&#44;5&#44;7</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;11</span></a> and in those with negative blood cultures&#44; cultures from other sites confirmed the infection&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#44;<a class="elsevierStyleCrossRef" href="#bib0020">4</a>&#44;<a class="elsevierStyleCrossRef" href="#bib0030">6</a>&#44;<a class="elsevierStyleCrossRef" href="#bib0040">8</a> This was also the case in our patient&#44; in whom the organism was only isolated from a culture of the valve vegetation&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The current first-line treatment of IE due to <span class="elsevierStyleItalic">Trichosporon</span> spp&#46; is valve replacement associated with antifungal therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> The antifungal used in most of the reported cases was amphotericin B&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;8&#44;10&#44;11</span></a> although some authors suggest others&#44; including voriconazole&#46; Analysis of the effectiveness of antifungal therapy is hindered by the severity of patients suffering from <span class="elsevierStyleItalic">T&#46; beigelii</span> fungemia&#44; in whom mortality can reach 80&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Only four of the 11 reported cases were considered cured during hospital stay&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;7&#44;9&#44;11</span></a> while eight patients died during four years of medical follow-up&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;7&#44;9&#44;10</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusion</span><p id="par0050" class="elsevierStylePara elsevierViewall">Of the few cases of IE of prosthetic valves due to <span class="elsevierStyleItalic">T&#46; beigelii</span>&#44; the current case presents the longest interval between valve replacement surgery and diagnosis of infection by this pathogen&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">As in all the cases in the literature&#44; low clinical suspicion led to a delay in beginning appropriate therapy&#46; Considering the high mortality and severity of <span class="elsevierStyleItalic">T&#46; beigelii</span> endocarditis&#44; it should be considered when there is a prosthetic valve infection with negative blood cultures&#44; irrespective of the time elapsed since the previous surgery&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Trichosporon beigelii</span> is a non-pathogenic fungus that can however become an opportunist agent of disseminating and potentially fatal infections&#44; especially in immunocompromised patients&#46; In the literature&#44; there are only 11 published cases of infective endocarditis due to <span class="elsevierStyleItalic">T&#46; beigelii</span>&#46; Most of these cases involved immunocompetent individuals and the main risk factor was the presence of a prosthetic valve&#46; The longest interval between surgery and endocarditis was eight years&#46; In the present study&#44; a case of prosthetic valve endocarditis due to <span class="elsevierStyleItalic">T&#46; beigelii</span> is reported in an immunocompetent patient 11 years after mitral valve replacement&#46; As with similar cases&#44; low clinical suspicion and negative blood cultures delayed the beginning of antifungal therapy and cardiac surgery&#46; Considering the high mortality and severity of <span class="elsevierStyleItalic">T&#46; beigelii</span> endocarditis&#44; it should be considered when there is a prosthetic valve infection with negative blood cultures&#44; irrespective of the time elapsed since the previous surgery&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Trichosporon beigelii</span> &#233; um fungo n&#227;o patog&#234;nico&#44; que&#44; entretanto&#44; pode se tornar um agente oportunista de infec&#231;&#245;es disseminadas e potencialmente fatais&#44; especialmente em pacientes imunossuprimidos&#46; Na literatura&#44; foram relatados apenas onze casos de endocardite infecciosa &#40;EI&#41; por <span class="elsevierStyleItalic">T</span>&#46; <span class="elsevierStyleItalic">beigelii&#44;</span> sendo a maioria dos indiv&#237;duos imunocompetentes&#44; cujo &#250;nico fator de risco era a presen&#231;a de pr&#243;tese valvar&#46; O maior intervalo registrado entre a cirurgia e a endocardite foi de oito anos&#46; No presente estudo&#44; ser&#225; relatado um caso de endocardite de valva prot&#233;tica por <span class="elsevierStyleItalic">Trichosporon beigelii</span> em paciente imunocompetente&#44; onze anos ap&#243;s troca valvar mitral&#46; Como nos demais relatos&#44; a baixa suspei&#231;&#227;o cl&#237;nica e hemoculturas negativas levaram ao atraso no in&#237;cio da terapia antif&#250;ngica e cirurgia card&#237;aca&#46; Devido &#224; alta gravidade e mortalidade da endocardite por <span class="elsevierStyleItalic">Trichosporon beigelii</span>&#44; este relato de caso sugere que a mesma deve ser considerada nos casos de infec&#231;&#227;o de valva prot&#233;tica&#44; mesmo com hemoculturas negativas&#44; independentemente do tempo da interven&#231;&#227;o&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Couto R&#44; Couto G&#44; Abrah&#227;o I&#44; Compagnoni I&#44; Carnio T&#44; Tolentino J&#44; Endocardite por <span class="elsevierStyleItalic">Trichosporon beigelii</span> 11 anos ap&#243;s cirurgia de troca valvar mitral&#46; Rev Port Cardiol&#46; 2021&#59;40&#58;305&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Transesophageal echocardiogram with images suggesting mobile vegetations on the mitral valve prosthesis &#40;arrows&#41;&#46; AE&#58; left atrium&#59; AD&#58; right atrium&#59; PM&#58; mitral bioprosthetic valve&#59; VD&#58; right ventricle&#59; VE&#58; left ventricle&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:11 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of <span class="elsevierStyleItalic">Trichosporon beigelii</span> endocarditis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Mooty"
                            1 => "S&#46; Kanj"
                            2 => "M&#46; Obeid"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Clin Microbiol Infect Dis"
                        "fecha" => "2001"
                        "volumen" => "20"
                        "paginaInicial" => "0139"
                        "paginaFinal" => "0142"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Trichosporon beigelii</span> endocarditis as a complication of peritoneovenous shunt"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Reyes"
                            1 => "M&#46; Stanley"
                            2 => "J&#46; Rippon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0046-8177(85)80262-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Pathol"
                        "fecha" => "1985"
                        "volumen" => "16"
                        "paginaInicial" => "857"
                        "paginaFinal" => "859"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4018785"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of <span class="elsevierStyleItalic">Trichosporon beigelii</span> endocarditis 8 years after aortic valve replacement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Sidarous"
                            1 => "M&#46; O&#8217;Reilly"
                            2 => "C&#46; Cherubin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Infect Dis Newsl"
                        "fecha" => "1992"
                        "volumen" => "11"
                        "paginaInicial" => "61"
                        "paginaFinal" => "63"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Trichosporon cutaneum</span> endocarditis&#58; a sequela of intravenous drug abuse"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Brahn"
                            1 => "P&#46; Leonard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ajcp/78.5.792"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Clin Pathol"
                        "fecha" => "1982"
                        "volumen" => "78"
                        "paginaInicial" => "792"
                        "paginaFinal" => "794"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6890308"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recurrent <span class="elsevierStyleItalic">Trichosporon beigelii</span> endocarditis after aortic valve replacement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Miralles"
                            1 => "J&#46; Quiroga"
                            2 => "T&#46; Farinola"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Surg"
                        "fecha" => "1994"
                        "volumen" => "2"
                        "paginaInicial" => "119"
                        "paginaFinal" => "123"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8049917"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term survival of a patient with prosthetic valve endocarditis due to <span class="elsevierStyleItalic">Trichosporon beigelii</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Martinez-Lacasa"
                            1 => "J&#46; Ma&#241;a"
                            2 => "R&#46; Niubo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF01972504"
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur J Clin Microbiol Infect Dis"
                        "fecha" => "1991"
                        "volumen" => "10"
                        "paginaInicial" => "756"
                        "paginaFinal" => "758"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1810731"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0920996419302944"
                          "estado" => "S300"
                          "issn" => "09209964"
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                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endocarditis due to <span class="elsevierStyleItalic">Trichosporon beigelii</span>&#58; in vitro susceptibility of isolates and review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Keay"
                            1 => "D&#46; Denning"
                            2 => "D&#46; Stevens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "1991"
                        "volumen" => "13"
                        "paginaInicial" => "383"
                        "paginaFinal" => "386"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prosthetic valve endocarditis caused by <span class="elsevierStyleItalic">Trichosporon beigelii</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
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                            1 => "D&#46; Urbanski"
                            2 => "S&#46; Harrington"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1988"
                        "volumen" => "84"
                        "paginaInicial" => "355"
                        "paginaFinal" => "358"
                        "itemHostRev" => array:3 [
                          "pii" => "S0165178118314380"
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            8 => array:3 [
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              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prosthetic valve endocarditis caused by <span class="elsevierStyleItalic">Trichosporon cutaneum</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46; Thomas"
                            1 => "A&#46; Mogahed"
                            2 => "J&#46;P&#46; Leclerc"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0167-5273(84)90061-5"
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Cardiol"
                        "fecha" => "1984"
                        "volumen" => "5"
                        "paginaInicial" => "83"
                        "paginaFinal" => "87"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6319306"
                            "web" => "Medline"
                          ]
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                          "pii" => "S0165178116304371"
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Case report
Endocarditis due to Trichosporon beigelii 11 years after mitral valve replacement
Endocardite por Trichosporon beigelii 11 anos após cirurgia de troca valvar mitral
Renata Coutoa,
Corresponding author
, Gustavo Coutob, Ingrid Abrahãoa, Inaê Compagnonia, Tatiane Carnioa, Julio Tolentinoa
a Departamento de Medicina Interna, Escola de Medicina e Cirurgia, Universidade Federal do Rio de Janeiro, Rio Janeiro, RJ, Brazil
b Serviço de Cirurgia Cardíaca, Hospital São Lucas, Nova Friburgo, RJ, Brazil
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Of these 11 cases&#44; nine presented endocarditis on a prosthetic valve&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#44;5&#8211;11</span></a> in five of which the prosthetic mitral valve was affected&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;7&#8211;11</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The longest interval between surgery and IE of a prosthetic valve reported in the literature was eight years&#46; In the present study&#44; a case of prosthetic valve IE due to <span class="elsevierStyleItalic">T&#46; beigelii</span> is reported in an immunocompetent patient 11 years after valve replacement&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0020" class="elsevierStylePara elsevierViewall">A 57-year-old man with a bioprosthetic mitral valve implanted 11 years previously was admitted with a history of high fever and chills in the previous 15 days&#46; He denied intravenous drug abuse&#44; diabetes&#44; malignancy or other immunosuppressive conditions&#46; On physical examination he was febrile &#40;axillary temperature 38&#46;4<span class="elsevierStyleHsp" style=""></span>&#176;C&#41;&#44; with blood pressure of 125&#47;78<span class="elsevierStyleHsp" style=""></span>mmHg and heart rate of 118<span class="elsevierStyleHsp" style=""></span>bpm&#46; Cardiovascular assessment showed regular heart rhythm&#44; normal heart sounds and a significant systolic murmur in the mitral focus&#46; The rest of the examination was normal&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Laboratory tests showed slight leukocytosis without eosinophilia&#46; Transthoracic echocardiography revealed an image suggesting vegetations on the biological valve&#44; which was confirmed by transesophageal echocardiography &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46; Blood cultures were taken and empirical antimicrobial therapy was begun&#44; but the patient&#8217;s infection worsened and he developed hemodynamic instability&#46; The mitral bioprosthesis was accordingly replaced by a metal valve&#46; The vegetation adhering to the bioprosthesis was cultured and following macroscopic examination &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41; amphotericin B was added&#46; On the sixth postoperative day growth of <span class="elsevierStyleItalic">T&#46; beigelii</span> was observed in the culture from the bioprosthesis and&#44; in view of clinical deterioration&#44; the antifungal was replaced by voriconazole&#46; However&#44; the patient developed multiorgan failure and died on the 13th day after surgical intervention&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">In the literature&#44; there are only 11 published cases of IE due to <span class="elsevierStyleItalic">T&#46; beigelii&#46;</span><a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;11</span></a> In the nine reports of cases affecting prosthetic valves&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#44;5&#8211;11</span></a> the mean interval between cardiac surgery and the diagnosis of IE was four years&#44; ranging between three months and eight years&#46; The present case is unusual in that 11 years had passed after valve replacement&#44; making this the longest period so far recorded&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">There are no laboratory findings characteristic of trichosporonemia&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a> which often delays diagnosis of this serious condition&#46; Eosinophilia was observed in only four<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5&#44;6&#44;8</span></a> of the 11 reported cases and was not seen in the present case&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Blood cultures are frequently negative in systemic trichosporonosis&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> although they revealed the presence of <span class="elsevierStyleItalic">Trichosporon</span> spp&#46; in seven of the reported cases&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3&#44;5&#44;7</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;11</span></a> and in those with negative blood cultures&#44; cultures from other sites confirmed the infection&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#44;<a class="elsevierStyleCrossRef" href="#bib0020">4</a>&#44;<a class="elsevierStyleCrossRef" href="#bib0030">6</a>&#44;<a class="elsevierStyleCrossRef" href="#bib0040">8</a> This was also the case in our patient&#44; in whom the organism was only isolated from a culture of the valve vegetation&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The current first-line treatment of IE due to <span class="elsevierStyleItalic">Trichosporon</span> spp&#46; is valve replacement associated with antifungal therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> The antifungal used in most of the reported cases was amphotericin B&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;8&#44;10&#44;11</span></a> although some authors suggest others&#44; including voriconazole&#46; Analysis of the effectiveness of antifungal therapy is hindered by the severity of patients suffering from <span class="elsevierStyleItalic">T&#46; beigelii</span> fungemia&#44; in whom mortality can reach 80&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Only four of the 11 reported cases were considered cured during hospital stay&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;7&#44;9&#44;11</span></a> while eight patients died during four years of medical follow-up&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;7&#44;9&#44;10</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusion</span><p id="par0050" class="elsevierStylePara elsevierViewall">Of the few cases of IE of prosthetic valves due to <span class="elsevierStyleItalic">T&#46; beigelii</span>&#44; the current case presents the longest interval between valve replacement surgery and diagnosis of infection by this pathogen&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">As in all the cases in the literature&#44; low clinical suspicion led to a delay in beginning appropriate therapy&#46; Considering the high mortality and severity of <span class="elsevierStyleItalic">T&#46; beigelii</span> endocarditis&#44; it should be considered when there is a prosthetic valve infection with negative blood cultures&#44; irrespective of the time elapsed since the previous surgery&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Trichosporon beigelii</span> is a non-pathogenic fungus that can however become an opportunist agent of disseminating and potentially fatal infections&#44; especially in immunocompromised patients&#46; In the literature&#44; there are only 11 published cases of infective endocarditis due to <span class="elsevierStyleItalic">T&#46; beigelii</span>&#46; Most of these cases involved immunocompetent individuals and the main risk factor was the presence of a prosthetic valve&#46; The longest interval between surgery and endocarditis was eight years&#46; In the present study&#44; a case of prosthetic valve endocarditis due to <span class="elsevierStyleItalic">T&#46; beigelii</span> is reported in an immunocompetent patient 11 years after mitral valve replacement&#46; As with similar cases&#44; low clinical suspicion and negative blood cultures delayed the beginning of antifungal therapy and cardiac surgery&#46; Considering the high mortality and severity of <span class="elsevierStyleItalic">T&#46; beigelii</span> endocarditis&#44; it should be considered when there is a prosthetic valve infection with negative blood cultures&#44; irrespective of the time elapsed since the previous surgery&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Trichosporon beigelii</span> &#233; um fungo n&#227;o patog&#234;nico&#44; que&#44; entretanto&#44; pode se tornar um agente oportunista de infec&#231;&#245;es disseminadas e potencialmente fatais&#44; especialmente em pacientes imunossuprimidos&#46; Na literatura&#44; foram relatados apenas onze casos de endocardite infecciosa &#40;EI&#41; por <span class="elsevierStyleItalic">T</span>&#46; <span class="elsevierStyleItalic">beigelii&#44;</span> sendo a maioria dos indiv&#237;duos imunocompetentes&#44; cujo &#250;nico fator de risco era a presen&#231;a de pr&#243;tese valvar&#46; O maior intervalo registrado entre a cirurgia e a endocardite foi de oito anos&#46; No presente estudo&#44; ser&#225; relatado um caso de endocardite de valva prot&#233;tica por <span class="elsevierStyleItalic">Trichosporon beigelii</span> em paciente imunocompetente&#44; onze anos ap&#243;s troca valvar mitral&#46; Como nos demais relatos&#44; a baixa suspei&#231;&#227;o cl&#237;nica e hemoculturas negativas levaram ao atraso no in&#237;cio da terapia antif&#250;ngica e cirurgia card&#237;aca&#46; Devido &#224; alta gravidade e mortalidade da endocardite por <span class="elsevierStyleItalic">Trichosporon beigelii</span>&#44; este relato de caso sugere que a mesma deve ser considerada nos casos de infec&#231;&#227;o de valva prot&#233;tica&#44; mesmo com hemoculturas negativas&#44; independentemente do tempo da interven&#231;&#227;o&#46;</p></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Transesophageal echocardiogram with images suggesting mobile vegetations on the mitral valve prosthesis &#40;arrows&#41;&#46; AE&#58; left atrium&#59; AD&#58; right atrium&#59; PM&#58; mitral bioprosthetic valve&#59; VD&#58; right ventricle&#59; VE&#58; left ventricle&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Surgical specimen of the mitral valve prosthesis &#40;left ventricular face&#41;&#46; Arrows show friable vegetations adhering to the three valve leaflets&#46;</p>"
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      "seccion" => array:1 [
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            0 => array:3 [
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              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of <span class="elsevierStyleItalic">Trichosporon beigelii</span> endocarditis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Mooty"
                            1 => "S&#46; Kanj"
                            2 => "M&#46; Obeid"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Clin Microbiol Infect Dis"
                        "fecha" => "2001"
                        "volumen" => "20"
                        "paginaInicial" => "0139"
                        "paginaFinal" => "0142"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Trichosporon beigelii</span> endocarditis as a complication of peritoneovenous shunt"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Reyes"
                            1 => "M&#46; Stanley"
                            2 => "J&#46; Rippon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0046-8177(85)80262-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Pathol"
                        "fecha" => "1985"
                        "volumen" => "16"
                        "paginaInicial" => "857"
                        "paginaFinal" => "859"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4018785"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of <span class="elsevierStyleItalic">Trichosporon beigelii</span> endocarditis 8 years after aortic valve replacement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Sidarous"
                            1 => "M&#46; O&#8217;Reilly"
                            2 => "C&#46; Cherubin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Infect Dis Newsl"
                        "fecha" => "1992"
                        "volumen" => "11"
                        "paginaInicial" => "61"
                        "paginaFinal" => "63"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Trichosporon cutaneum</span> endocarditis&#58; a sequela of intravenous drug abuse"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Brahn"
                            1 => "P&#46; Leonard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ajcp/78.5.792"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Clin Pathol"
                        "fecha" => "1982"
                        "volumen" => "78"
                        "paginaInicial" => "792"
                        "paginaFinal" => "794"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6890308"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recurrent <span class="elsevierStyleItalic">Trichosporon beigelii</span> endocarditis after aortic valve replacement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Miralles"
                            1 => "J&#46; Quiroga"
                            2 => "T&#46; Farinola"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Surg"
                        "fecha" => "1994"
                        "volumen" => "2"
                        "paginaInicial" => "119"
                        "paginaFinal" => "123"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8049917"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term survival of a patient with prosthetic valve endocarditis due to <span class="elsevierStyleItalic">Trichosporon beigelii</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Martinez-Lacasa"
                            1 => "J&#46; Ma&#241;a"
                            2 => "R&#46; Niubo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF01972504"
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur J Clin Microbiol Infect Dis"
                        "fecha" => "1991"
                        "volumen" => "10"
                        "paginaInicial" => "756"
                        "paginaFinal" => "758"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1810731"
                            "web" => "Medline"
                          ]
                        ]
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                          "pii" => "S0920996419302944"
                          "estado" => "S300"
                          "issn" => "09209964"
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                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endocarditis due to <span class="elsevierStyleItalic">Trichosporon beigelii</span>&#58; in vitro susceptibility of isolates and review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Keay"
                            1 => "D&#46; Denning"
                            2 => "D&#46; Stevens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "1991"
                        "volumen" => "13"
                        "paginaInicial" => "383"
                        "paginaFinal" => "386"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
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Article information
ISSN: 21742049
Original language: English
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Revista Portuguesa de Cardiologia (English edition)
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