Resistance training improves cardiovascular autonomic control and biochemical profile of rats exposed to a Western diet in the perinatal period | Revista Portuguesa de Cardiologia (English edition)

array:25 ["pii" => "S2174204919301497" "issn" => "21742049" "doi" => "10.1016/j.repce.2018.08.008" "estado" => "S300" "fechaPublicacion" => "2019-05-01" "aid" => "1384" "copyright" => "Sociedade Portuguesa de Cardiologia" "copyrightAnyo" => "2019" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2019;38:337-45" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 340 "formatos" => array:3 [ "EPUB" => 52 "HTML" => 166 "PDF" => 122 ] ] "Traduccion" => array:1 [ "pt" => array:20 [ "pii" => "S0870255118300751" "issn" => "08702551" "doi" => "10.1016/j.repc.2018.08.009" "estado" => "S300" "fechaPublicacion" => "2019-05-01" "aid" => "1384" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2019;38:337-45" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 535 "formatos" => array:3 [ "EPUB" => 50 "HTML" => 286 "PDF" => 199 ] ] "pt" => array:13 [ "idiomaDefecto" => true "cabecera" => "Artigo Original" "titulo" => "Treinamento resistido melhora controle autonômico cardiovascular e perfil bioquímico de ratos expostos a dieta ocidental no período perinatal" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "337" "paginaFinal" => "345" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Resistance training improves cardiovascular autonomic control and biochemical profile of rats exposed to Western diet in the perinatal period" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2625 "Ancho" => 2463 "Tamanyo" => 168092 ] ] "descripcion" => array:1 [ "pt" => "Modulação autonômica cardiovascular e sensibilidade espontânea do barorreflexo após quatro semanas de TR. C: grupo controle; OCS: grupo dieta ocidental sedentário; OCTR: grupo dieta ocidental treinado; HF: high frequency; LF: low frequency; Lfsys: LF da pressão arterial; SBR: sensibilidade do barorreflexo.*p < 0,05: OCTR vs OCS; #p < 0,05: OCTR vs C; §p < 0,05: OCS vs C. Foi utilizado o teste Anova de uma via, seguido por pós‐teste de Bonferroni." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Michael Nadson Santos Santana, Vitor Ulisses De Melo, Fabricio Nunes Macedo, André Sales Barreto, Robervan Vidal‐Santos, Mario Matiotti Neto, Marcio Roberto Viana dos Santos, Valter Joviniano Santana‐Filho" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Michael Nadson Santos" "apellidos" => "Santana" ] 1 => array:2 [ "nombre" => "Vitor Ulisses" "apellidos" => "De Melo" ] 2 => array:2 [ "nombre" => "Fabricio Nunes" "apellidos" => "Macedo" ] 3 => array:2 [ "nombre" => "André Sales" "apellidos" => "Barreto" ] 4 => array:2 [ "nombre" => "Robervan" "apellidos" => "Vidal‐Santos" ] 5 => array:2 [ "nombre" => "Mario" "apellidos" => "Matiotti Neto" ] 6 => array:2 [ "nombre" => "Marcio Roberto Viana dos" "apellidos" => "Santos" ] 7 => array:2 [ "nombre" => "Valter Joviniano" "apellidos" => "Santana‐Filho" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2174204919301539" "doi" => "10.1016/j.repce.2019.06.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204919301539?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255118300751?idApp=UINPBA00004E" "url" => "/08702551/0000003800000005/v3_201911281014/S0870255118300751/v3_201911281014/pt/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2174204919301539" "issn" => "21742049" "doi" => "10.1016/j.repce.2019.06.003" "estado" => "S300" "fechaPublicacion" => "2019-05-01" "aid" => "1397" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "dis" "cita" => "Rev Port Cardiol. 2019;38:347-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 260 "formatos" => array:3 [ "EPUB" => 42 "HTML" => 135 "PDF" => 83 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "Editorial comment" "titulo" => "Heartfelt exercise: Physical exercise gets the cardiovascular system into shape" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "347" "paginaFinal" => "348" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Sistema cardiovascular em forma com exercício físico" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Frederico C. Pereira" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Frederico" "apellidos" => "C. Pereira" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:2 [ "pt" => array:9 [ "pii" => "S0870255118300751" "doi" => "10.1016/j.repc.2018.08.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255118300751?idApp=UINPBA00004E" ] "en" => array:9 [ "pii" => "S0870255119303385" "doi" => "10.1016/j.repc.2019.06.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255119303385?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204919301539?idApp=UINPBA00004E" "url" => "/21742049/0000003800000005/v2_201911300820/S2174204919301539/v2_201911300820/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2174204919301564" "issn" => "21742049" "doi" => "10.1016/j.repce.2019.06.006" "estado" => "S300" "fechaPublicacion" => "2019-05-01" "aid" => "1396" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "dis" "cita" => "Rev Port Cardiol. 2019;38:333-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 427 "formatos" => array:3 [ "EPUB" => 58 "HTML" => 265 "PDF" => 104 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "Editorial comment" "titulo" => "Metabolic syndrome and cardiovascular risk" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "333" "paginaFinal" => "335" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Síndrome metabólica e risco cardiovascular" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Evangelista Rocha" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Evangelista" "apellidos" => "Rocha" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:2 [ "pt" => array:9 [ "pii" => "S0870255118300696" "doi" => "10.1016/j.repc.2018.06.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255118300696?idApp=UINPBA00004E" ] "en" => array:9 [ "pii" => "S0870255119303373" "doi" => "10.1016/j.repc.2019.06.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255119303373?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204919301564?idApp=UINPBA00004E" "url" => "/21742049/0000003800000005/v2_201911300820/S2174204919301564/v2_201911300820/en/main.assets" ] "en" => array:22 [ "idiomaDefecto" => true "cabecera" => "Original Article" "titulo" => "Resistance training improves cardiovascular autonomic control and biochemical profile of rats exposed to a Western diet in the perinatal period" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "337" "paginaFinal" => "345" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Michael Nadson Santos Santana, Vitor Ulisses De Melo, Fabricio Nunes Macedo, André Sales Barreto, Robervan Vidal-Santos, Matiotti Neto, Marcio Roberto Viana dos Santos, Valter Joviniano Santana-Filho" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Michael Nadson Santos" "apellidos" => "Santana" ] 1 => array:2 [ "nombre" => "Vitor Ulisses" "apellidos" => "De Melo" ] 2 => array:2 [ "nombre" => "Fabricio Nunes" "apellidos" => "Macedo" ] 3 => array:2 [ "nombre" => "André Sales" "apellidos" => "Barreto" ] 4 => array:2 [ "nombre" => "Robervan" "apellidos" => "Vidal-Santos" ] 5 => array:2 [ "nombre" => "Matiotti" "apellidos" => "Neto" ] 6 => array:2 [ "nombre" => "Marcio Roberto Viana" "apellidos" => "dos Santos" ] 7 => array:4 [ "nombre" => "Valter Joviniano" "apellidos" => "Santana-Filho" "email" => array:1 [ 0 => "vjsf@infonet.com.br" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Treinamento resistido melhora controle autonômico cardiovascular e perfil bioquímico de ratos expostos a dieta ocidental no período perinatal" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1237 "Ancho" => 3167 "Tamanyo" => 174812 ] ] "descripcion" => array:1 [ "en" => "Experimental design: mating, beginning of experimental diets, resistance training (RT) protocol and recording of cardiovascular variables." ] ] ] "textoCompleto" => "IntroductionEating patterns in the modern world are changing, with increasing consumption of low-cost, high-calorie, processed foods high in sodium and saturated fat and low in other essential nutrients. This is known as the Western diet.<a class="elsevierStyleCrossRefs" href="#bib0195">1,2</a> At the same time, technological advances and modern lifestyles have reduced the need for people to move, resulting in increased sedentarism. These factors are leading to increases in overweight and obesity.<a class="elsevierStyleCrossRef" href="#bib0205">3</a>Studies show that excessive consumption of nutrients in early life (intrauterine and/or pre- and post-natal stages) leads to morphological and functional changes in the fetus and to the development of cardiovascular disease in adulthood, in both animals<a class="elsevierStyleCrossRef" href="#bib0210">4</a> and humans,<a class="elsevierStyleCrossRef" href="#bib0215">5</a> a phenomenon known as fetal or metabolic programming.<a class="elsevierStyleCrossRefs" href="#bib0220">6,7</a>This process can alter phenotypic characteristics, leading to dysregulation of energy balances and to gains in body weight, predisposing the individual to obesity and associated comorbidities.<a class="elsevierStyleCrossRefs" href="#bib0230">8,9</a> In a previous study, we showed that animals fed a Western diet in the perinatal period had altered biochemical profiles and cardiovascular dysautonomia, followed by hypertension in adulthood.<a class="elsevierStyleCrossRef" href="#bib0235">9</a>Resistance training (RT) is used as a way to improve physical and muscular fitness, increase lean mass and maintain basal metabolic rate. RT has also been shown to foster beneficial adaptations in cardiovascular function.<a class="elsevierStyleCrossRefs" href="#bib0240">10,11</a>We therefore hypothesized that the cardiovascular benefits of RT are brought about by adaptations in blood pressure (BP) control mechanisms and that it will improve the biochemical profile of rats exposed to a Western diet in the perinatal period. Accordingly, the study aimed to observe the effects of RT on cardiovascular and biochemical variables in these animals.MethodsAnimalsThe present study meets the standards for conducting research on animals and its procedures followed the ethical principles of animal experimentation laid down by the Brazilian National Council for the Control of Animal Experimentation (CONCEA), based on the 2013 Brazilian guidelines for the care and use of animals for scientific and teaching purposes (DBCA). It was approved by the Committee on Animal Research and Ethics of the Federal University of Sergipe (CEPA/UFS), protocol 10/2014.Wistar rats of both sexes were kept in polypropylene cages with water and chow ad libitum at a temperature of 22±1 °C. Fifteen virgin female Wistar rats, aged between 90 and 120 days and weighing 250-300 g, were mated with fertile males in the proportion of four females to one male. A vaginal swab was used daily to check for pregnancy from the presence of sperm. The female rats were then divided into two groups according to diet: Control (n=5) and Western (n=5), until weaning. The litters were each adjusted to eight neonates 24 hours after birth, maintaining the same proportion of males and females when possible. Only males were used in the experimental protocols, to prevent the hormonal fluctuations due to the estrous cycle from influencing the results.After weaning, the pups were divided into three groups: Control (C, n=7), pups of mothers fed a control diet that did not perform RT; Western diet sedentary (WDS, n=7), pups of mothers fed with a Western diet that did not perform RT; and Western diet trained (WDRT, n=7), pups of mothers fed with a Western diet that performed RT.After weaning, the animals were fed with Labina® commercial chow for rodents. According to the manufacturer (Purina do Brasil Ltda), the chow contains minimum 23% crude protein, minimum 4% volatile substances, maximum 10% ash and 5% fiber, and has an energy content of 3.6 kcal/g.DietsThe control diet used during gestation and lactation was casein-based AIN-93G, specifically for growing rodents.<a class="elsevierStyleCrossRef" href="#bib0250">12</a> The formulation of the experimental Western diet was based on the Brazilian Household Budget Survey (HBS), with some adjustments to the percentages of its composition. These included increased lipid and simple carbohydrate content in order to enhance organoleptic factors, to give the feed a similarly pleasant odor and texture to the Western diet. The protein content was also adjusted, since the proportion of protein in the HBS diet is inadequate for the reproduction and growth stages in rats, and a final adjustment was made for the adult rats’ maintenance stage (15.5% protein).The Western diet contained 31% lipids, mainly saturated fats (67.59%), and 51.7% carbohydrates, mainly in the form of simple sugars, which resembles Western diets in humans, while the control diet contained 25.99% saturated fats and 55% carbohydrates.The Control (AIN-93G) and Western diets were produced by the Laboratory of Experimental Nutrition and Diet (LNED) of the Department of Nutrition of the Federal University of Pernambuco and were stored at 4 °C until used(<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>).<elsevierMultimedia ident="fig0010"></elsevierMultimedia>Resistance training protocolRT was performed using a squat-training apparatus.<a class="elsevierStyleCrossRef" href="#bib0255">13</a> The animals underwent a five-day adaptation period before training by being handled and placed in the device in the starting position of the exercise, with no added load.After adaptation, all the animals underwent a one-repetition maximum test (1RM) to determine the loads to be used. In the 1RM, the animal fully extends its hind legs under the maximum possible load while completing the movement. The desired intensity can thus be calculated based on the loads raised in the test. The RT protocol started after 48 hours, and consisted of three series of 10 repetitions with an intensity of 40% of 1RM (defined as low intensity),<a class="elsevierStyleCrossRef" href="#bib0260">14</a> with 1-min intervals between the series for recovery. Each RT session lasted approximately 5 min. RT was performed five times a week for four weeks, for a total of 20 RT sessions. A new 1RM was carried out every 15 days to adjust the loads.The animals were stimulated to perform the exercise by electrodes placed on the tail (BIOSET, Physiotonus four, Model 3050, Rio Claro, São Paulo). The parameters used were frequency 1 Hz, pulse width 1 ms, on time 1-3 s, off time 2 s, and sufficient intensity for the animals to perform the exercise (4-15 mA). The animals in groups C and WDS were placed in the squat-training apparatus and electrostimulated with the same parameters as for those in the WDRT group, but the equipment was kept in the rest position and without added load.Experimental designAssessment of cardiovascular functionThe animals were anesthetized with intraperitoneal (IP) sodium thiopental (50 mg/kg) and a polyethylene catheter (PE-10/PE-50, Intramedic, Becton Dickinson, Sparks, MD, USA) was surgically implanted in the left femoral artery. The catheter was exteriorized subcutaneously in the posterior cervical region. After surgery, the animals received 1.1 mg/kg IP of flunixin meglumine (Banamine®, Schering-Plough, Kenilworth, NJ, USA) to reduce hyperalgia and postoperative inflammation, for the animals’ well-being.Twenty-four hours after the procedure and after recovery from the effects of the anesthesia, the catheter was connected to a pressure transducer coupled to a pre-amplifier (FE221, Bridge Amp, ADInstruments, Bella Vista, NSW, Australia) using the PowerLab recording system (ADInstruments, Bella Vista, NSW, Australia). BP was recorded for 30 min and processed using LabChart 7 software (ADInstruments, Bella Vista, NSW, Australia), in order to identify inflection points and to generate beat-by-beat time series. All readings were taken in the morning, in order to ensure that behavioral factors would influence all the animals equally. Mean arterial pressure (MAP), systolic BP (SBP), diastolic BP (DBP), pulse interval (PI) and heart rate (HR) were measured and analyzed.Autonomic assessmentVariability in PI and SBP was analyzed using CardioSeries software, version 2.4 (<a href="http://sites.google.com/site/cardioseries">http://sites.google.com/site/cardioseries</a>), as described previously.<a class="elsevierStyleCrossRef" href="#bib0265">15</a> Beat-by-beat series were obtained based on the BP recordings and converted into 100-ms points (10 Hz) by cubic spline interpolation. The data were divided into partially overlapping sequences and periods of 512 points (51.2 s). For calculation of spectral power, the data were inspected visually and non-stationary segments were discarded.The spectrum was calculated directly by fast Fourier transform and a Hanning window was used to attenuate distortion. The spectrum was divided into low frequency (LF) (0.2-0.75 Hz) and high frequency (HF) (0.75-3 Hz) bands. The results were expressed in normalized units by dividing the LF and HF powers by the total power minus very low frequency (VLF) (<0.2 Hz) power. The LF component of PI represents cardiac sympathetic modulation, the HF component of PI is an index of vagal modulation, while the LF/HF ratio measures cardiac autonomic balance. The LF component of SBP represents vascular sympathetic modulation.Spontaneous baroreflex sensitivity (BRS) was quantified by the sequence method. The CardioSeries software was used to process beat-by-beat time series for SBP and PI, searching for sequences of at least four consecutive beats in which increases in SBP were followed by lengthening of PI and decreases in SBP were followed by shortening of PI. Data with a linear correlation of >0.85 were considered to be baroreflex sequences. The slope of the linear regression lines between SBP and PI was used as an index of BRS.<a class="elsevierStyleCrossRef" href="#bib0265">15</a>Biochemical assessmentThe animals were anesthetized with halothane after 12 hours fasting, and blood was collected from the retro-orbital plexus using heparinized capillary tubes. The sample was placed in a separation tube and centrifuged at 3500 rpm for 5 min to obtain plasma. The supernatant was drawn off using a pipette and transferred to an Eppendorf® tube, which was sent for biochemical analysis of glucose, total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL).A colorimetric enzyme assay (Bioclin, Belo Horizonte, Minas Gerais, Brazil) was used to measure plasma concentrations of the biochemical parameters, which were analyzed in an 800 XI spectrophotometer (Femto, São Paulo, Brazil), in accordance with the manufacturer's instructions. The Friedewald formula was used to measure LDL and very low density lipoprotein (VLDL).<a class="elsevierStyleCrossRef" href="#bib0270">16</a>Statistical analysisValues were reported as mean ± standard error of the mean. The results for hemodynamic assessment, autonomic modulation and biochemical profile were analyzed using one-way analysis of variance followed by the Bonferroni post hoc test to assess differences between means in the two groups. Values of p<0.05 were considered statistically significant. GraphPad software version 5.0 (San Diego, CA, USA) was used for the statistical analysis.ResultsChanges in body weight and one-repetition maximum test resultsAfter four weeks of RT, no significant difference was observed in the pups’ body mass (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Although the groups fed the Western diet had greater body mass before training, there was also no significant difference in the strength of the animals in the WDRT group compared to those in groups C and WDS.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Hemodynamic assessmentHemodynamic variables are presented in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>. The WDS group had higher BP at rest than groups C and WDRT, while the WDRT group had lower MAP, SBP and DBP than the WDS group. There were no differences in HR between the groups.<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>Cardiovascular autonomic modulationThe results for autonomic modulation are shown in <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>. The WDS group presented an increase in the LF component (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>a) and a reduction in HF (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>b). RT attenuated this alteration, producing a reduction in LF and an increase in HF (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>c).<elsevierMultimedia ident="fig0005"></elsevierMultimedia>In addition, the high LF component of SBP had high values in the WDS group, while for WDRT animals this variable was low (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>d). Although BRS was unchanged as a result of the Western diet, there was an increase in BRS in animals in the WDRT group (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>e) compared to the WDS group.Biochemical variablesThe results for the biochemical variables of fasting blood glucose, TC, HDL, LDL, VLDL and TG can be observed in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>. The WDS group had higher fasting blood glucose, TC and LDL than group C, whereas the WDRT group had lower blood glucose, TC and LDL and higher HDL.<elsevierMultimedia ident="tbl0015"></elsevierMultimedia>DiscussionThe results of the present study show that a Western diet fed to Wistar rats during the perinatal period had important physiological effects, including increased serum glucose, TC, and LDL and reduced HDL. The Western diet also led to dysautonomia, promoting cardiovascular sympathetic modulation and hypertension in adulthood. These findings corroborate previous results from our laboratory using the same experimental protocol and diet.<a class="elsevierStyleCrossRef" href="#bib0235">9</a>Low-intensity RT (40% of 1RM) does not lead to alterations in body mass or strength gain, although individuals on fitness programs show changes in body composition.<a class="elsevierStyleCrossRefs" href="#bib0275">17,18</a> The American College of Sports Medicine (ACSM)<a class="elsevierStyleCrossRef" href="#bib0260">14</a> recommend, in RT programs aimed at increasing muscle strength, loads corresponding to 60-70% of 1RM for novice to intermediate individuals and 80-100% of 1RM for advanced individuals. Programs designed for increasing muscular hypertrophy should use loads of 70-85% of 1RM for novice and intermediate individuals and 70-100% for advanced training. Baraúna et al. observed increased muscle strength in mice trained on apparatus similar to that used in our study, although using workloads of 75% of 1RM, supporting the ACSM's recommendations.<a class="elsevierStyleCrossRef" href="#bib0260">14</a> Our results show that the intensity and duration of RT used in the present study did not lead to modifications in body mass or strength in these animals.To our knowledge, this is the first study to show that low-intensity RT reduces sympathetic modulation, increases BRS and improves the lipid and glycemic profiles of animals exposed to a Western diet in the perinatal period, which did not develop the hypertension observed in sedentary animals on the same diet. Animals exposed to a Western diet and to RT presented lower BP and improvements in most biochemical variables. RT improved BRS, without increasing the LF component but increasing the HF component of PI. The mechanisms behind this effect may be associated with adjustments in central BP control mechanisms.Physical exercise has been associated with various cardiovascular adaptations, including reduced vascular resistance,<a class="elsevierStyleCrossRefs" href="#bib0285">19,20</a> cardiac remodeling, lower blood pressure, reduced HR<a class="elsevierStyleCrossRef" href="#bib0295">21</a> and increased expression of endothelium-derived relaxing factors.<a class="elsevierStyleCrossRef" href="#bib0300">22</a>It has been shown that aerobic exercise induces neural changes in autonomic nuclei, increasing noradrenergic signaling from the nucleus of the solitary tract (NST) to pre-autonomic neurons in the paraventricular nucleus (PVN) of the hypothalamus, increasing the intrinsic excitability of neurons in the PVN-NST pathway, and increasing vagal tone through the release of acetylcholine by the vagus nerve.<a class="elsevierStyleCrossRefs" href="#bib0305">23,24</a> The same training model leads to an increase in mRNA of the oxytocin receptor in the medulla and greater expression of this neurotransmitter in the PVN,<a class="elsevierStyleCrossRefs" href="#bib0305">23,25,26</a> which correlates with improvement in baroreflex control.<a class="elsevierStyleCrossRefs" href="#bib0310">24,27</a> These adjustments may help to reduce sympathetic tone in hypertensive subjects.<a class="elsevierStyleCrossRef" href="#bib0305">23</a>We observed that RT also led to beneficial adaptations in the cardiovascular system, including lower BP, increased BRS and improvement in sympathovagal balance, corroborating previous findings by our group,<a class="elsevierStyleCrossRef" href="#bib0240">10</a> although the mechanisms involved in these responses remain to be elucidated.Sedentary animals that consumed a Western diet at the start of life presented increased vascular sympathetic modulation, as observed in a previous study carried out in our laboratory,<a class="elsevierStyleCrossRef" href="#bib0235">9</a> while this variable decreased in the group that performed RT. The consumption of high-calorie and high-fat diets is directly related to increases in adipose tissue and obesity, which leads to sympathetic hyperactivity, promoting peripheral vasoconstriction and hypertension.<a class="elsevierStyleCrossRef" href="#bib0330">28</a> There is evidence that reduced sympathetic action in blood vessels helps to decrease BP, mediated by changes in vascular stiffness.<a class="elsevierStyleCrossRef" href="#bib0335">29</a>Previous studies carried out in our laboratory using the same exercise model showed that RT enhances acetylcholine- and insulin-induced vasodilation, increases the bioavailability of nitric oxide, and improves sympathovagal balance and vasodilation capacity. Collectively, these factors help reduce BP.<a class="elsevierStyleCrossRefs" href="#bib0240">10,30–32</a>The nutritional insult induced in the animals at the start of life caused metabolic disorders, with increases in TC, LDL and blood glucose, as previously observed.<a class="elsevierStyleCrossRefs" href="#bib0235">9,33</a> In models of obesity, insulin resistance is associated with reduced expression of glucose transporter 4 (GLUT4) and impairment of the insulin signaling pathway.<a class="elsevierStyleCrossRef" href="#bib0355">34</a> RT increases the expression of GLUT4, improving insulin response in skeletal muscle and adipose tissue.<a class="elsevierStyleCrossRefs" href="#bib0345">32,35,36</a> The reduction in blood glucose observed in this study probably results from improved glucose transportation through GLUT4 translocation.The trained rats exposed to a Western diet had lower LDL, corroborating studies in which RT reduced this variable in different populations.<a class="elsevierStyleCrossRefs" href="#bib0370">37,38</a> Higher serum lipid concentrations increase arterial fat deposits and impair vascular elasticity caused by LDL deposition, which may evolve to atherosclerosis.<a class="elsevierStyleCrossRef" href="#bib0380">39</a>No change was noted in HDL as a result of the consumption of the Western diet. However, the trained animals showed an increase in HDL, which helps to protect the vascular bed. This shows that RT can have an antiatherogenic role.ConclusionsTo summarize, our results showed that a Western diet at the perinatal stage leads to dysautonomia and metabolic disorders, resulting in hypertension in adulthood, while an RT protocol reduced BP through positive adjustments in autonomic control mechanisms and improved BRS. Furthermore, RT reduced blood glucose and TC and improved the HDL/LDL ratio.Understanding the mechanisms by which RT improves autonomic control and biochemical profiles in experimental animals offers new possibilities for the prevention and treatment of cardiometabolic disorders caused by inappropriate diet. Further studies should be conducted to elucidate the molecular and epigenetic mechanisms involved in the genesis of metabolic disorders and to understand how exercise can influence central control mechanisms, going beyond endothelial mechanisms based on the release of vasoactive substances.Conflicts of interestThe authors have no conflicts of interest to declare." "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres1270535" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction and Objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1175806" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1270536" "titulo" => "Resumo" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introdução e objetivos" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1175807" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Animals" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Diets" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Resistance training protocol" ] 3 => array:3 [ "identificador" => "sec0030" "titulo" => "Experimental design" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "Assessment of cardiovascular function" ] 1 => array:2 [ "identificador" => "sec0040" "titulo" => "Autonomic assessment" ] 2 => array:2 [ "identificador" => "sec0045" "titulo" => "Biochemical assessment" ] ] ] 4 => array:2 [ "identificador" => "sec0050" "titulo" => "Statistical analysis" ] ] ] 6 => array:3 [ "identificador" => "sec0055" "titulo" => "Results" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0060" "titulo" => "Changes in body weight and one-repetition maximum test results" ] 1 => array:2 [ "identificador" => "sec0065" "titulo" => "Hemodynamic assessment" ] 2 => array:2 [ "identificador" => "sec0070" "titulo" => "Cardiovascular autonomic modulation" ] 3 => array:2 [ "identificador" => "sec0075" "titulo" => "Biochemical variables" ] ] ] 7 => array:2 [ "identificador" => "sec0080" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0085" "titulo" => "Conclusions" ] 9 => array:2 [ "identificador" => "sec0090" "titulo" => "Conflicts of interest" ] 10 => array:2 [ "identificador" => "xack436056" "titulo" => "Acknowledgments" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-02-14" "fechaAceptado" => "2018-08-24" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1175806" "palabras" => array:3 [ 0 => "Resistance training" 1 => "Autonomic nervous system" 2 => "Western diet" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec1175807" "palabras" => array:3 [ 0 => "Treinamento de resistência" 1 => "Sistema nervoso autônomo" 2 => "Dieta ocidental" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "Introduction and ObjectivesConsumption of a Western diet during the perinatal period is associated with development of cardiovascular disease. Resistance training (RT) has been used to treat cardiovascular disorders. The aim of this work was to assess the effect of RT on cardiometabolic disorders in rats exposed to a Western diet in the perinatal period. MethodsFemale Wistar rats were fed with control or Western diet during pregnancy and lactation. The pups were divided into three groups: Control (C), Western Diet Sedentary (WDS) and Western Diet+RT (WDRT). At 60 days of age, all animals started the RT protocol (five times a week for four weeks). At the end, blood pressure was recorded for analysis of heart rate variability and baroreflex sensitivity (BRS). Blood samples were collected for biochemical analysis. ResultsRT reduced blood pressure and vascular sympathetic modulation and increased BRS. There were improvements in biochemical profile, with reductions in fasting blood glucose, total cholesterol and low-density lipoprotein, and an increase in high-density lipoprotein. ConclusionRT led to beneficial adaptations in the cardiovascular system, mediated by changes in the mechanisms of autonomic control and biochemical profile of animals exposed to a Western diet in the perinatal period." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction and Objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "pt" => array:3 [ "titulo" => "Resumo" "resumen" => "Introdução e objetivosO consumo da dieta ocidental está associado ao surgimento de doenças cardiovasculares. O treinamento de resistência (TR) tem sido utilizado no tratamento destas doenças. O objetivo deste trabalho foi avaliar o efeito do TR sobre as alterações cardiometabólicas na prole de ratas expostas a dieta ocidental no período perinatal. MétodosRatas Wistar receberam dieta controle ou ocidental durante a gravidez e lactação. Os filhotes foram divididos em três grupos: Controle (C), dieta ocidental sedentário (OCS) e dieta ocidental+TR (OCTR). Aos 60 dias de vida, os animais iniciaram o protocolo de TR realizado cinco vezes por semana durante quatro semanas. Ao fim, foi registrada pressão arterial para análise da variabilidade da frequência cardíaca e sensibilidade do barorreflexo (SBR). Amostras de sangue foram coletadas para análise bioquímica. ResultadosO TR foi capaz de reduzir a pressão arterial, a modulação simpática vascular e aumentar a SBR. Houve melhoria no perfil bioquímico, com redução na glicemia de jejum, colesterol total e lipoproteínas de baixa densidade, além de aumento das lipoproteínas de alta densidade. ConclusãoO TR promoveu adaptações benéficas ao sistema cardiovascular, mediadas por ajustes nos mecanismos de controle autonômico e perfil bioquímico dos animais expostos à dieta ocidental no período perinatal." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introdução e objetivos" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Santana MNS, De Melo VU, Macedo FN, et al. Treinamento resistido melhora controle autonômico cardiovascular e perfil bioquímico de ratos expostos a dieta ocidental no período perinatal. Rev Port Cardiol. 2019;38:337–345." ] ] "nomenclatura" => array:1 [ 0 => array:3 [ "identificador" => "nom0005" "titulo" => "List of abbreviations" "listaDefinicion" => array:1 [ 0 => array:1 [ "definicion" => array:24 [ 0 => array:2 [ "termino" => "1RM" "descripcion" => "one-repetition maximum test" ] 1 => array:2 [ "termino" => "ACSM" "descripcion" => "American College of Sports Medicine" ] 2 => array:2 [ "termino" => "BP" "descripcion" => "blood pressure" ] 3 => array:2 [ "termino" => "BRS" "descripcion" => "baroreflex sensitivity" ] 4 => array:2 [ "termino" => "DBP" "descripcion" => "diastolic blood pressure" ] 5 => array:2 [ "termino" => "GLUT4" "descripcion" => "glucose transporter 4" ] 6 => array:2 [ "termino" => "HBS" "descripcion" => "Household Budget Survey" ] 7 => array:2 [ "termino" => "HDL" "descripcion" => "high-density lipoprotein" ] 8 => array:2 [ "termino" => "HF" "descripcion" => "high frequency component" ] 9 => array:2 [ "termino" => "HR" "descripcion" => "heart rate" ] 10 => array:2 [ "termino" => "LDL" "descripcion" => "low-density lipoprotein" ] 11 => array:2 [ "termino" => "LF" "descripcion" => "low frequency component" ] 12 => array:2 [ "termino" => "MAP" "descripcion" => "mean arterial pressure" ] 13 => array:2 [ "termino" => "NST" "descripcion" => "nucleus of the solitary tract" ] 14 => array:2 [ "termino" => "PI" "descripcion" => "pulse interval" ] 15 => array:2 [ "termino" => "PVN" "descripcion" => "paraventricular nucleus of the hypothalamus" ] 16 => array:2 [ "termino" => "RT" "descripcion" => "resistance training" ] 17 => array:2 [ "termino" => "SBP" "descripcion" => "systolic blood pressure" ] 18 => array:2 [ "termino" => "TC" "descripcion" => "total cholesterol" ] 19 => array:2 [ "termino" => "TG" "descripcion" => "triglycerides" ] 20 => array:2 [ "termino" => "VLDL" "descripcion" => "very low-density lipoprotein" ] 21 => array:2 [ "termino" => "VLF" "descripcion" => "very low frequency component" ] 22 => array:2 [ "termino" => "WDRT" "descripcion" => "Western diet trained" ] 23 => array:2 [ "termino" => "WDS" "descripcion" => "Western diet sedentary" ] ] ] ] ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2625 "Ancho" => 2463 "Tamanyo" => 171525 ] ] "descripcion" => array:1 [ "en" => "Cardiovascular autonomic modulation and spontaneous baroreflex sensitivity after four weeks of resistance training. BRS: baroreflex sensitivity; C: control group; HF: high frequency; LF: low frequency; LFSBP: low frequency component of systolic blood pressure; NU: normalized units; WDRT: Western diet trained group; WDS: Western diet sedentary group. ap<0.05 for WDRT vs. WDS; p<0.05 for WDRT vs. C; bp<0.05 for WDS vs. C; cp<0.05 for WDRT vs. C. One-way analysis of variance was used followed by the Bonferroni post hoc test." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1237 "Ancho" => 3167 "Tamanyo" => 174812 ] ] "descripcion" => array:1 [ "en" => "Experimental design: mating, beginning of experimental diets, resistance training (RT) protocol and recording of cardiovascular variables." ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "1RM: one-repetition maximum; C: control group; WDRT: Western diet trained group; WDS: Western diet sedentary group." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Period \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C (n=7) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">WDS (n=7) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">WDRT (n=7) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="middle">Body mass, g</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Initial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">266.3±2.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">280.3±6.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">277.3±4.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Final \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">300±3.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">308.4±5.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">309.1±3.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="middle">1RM, g</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Initial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1340±58.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1420±81.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1480±55.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Final \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1560±54.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1710±83.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1770±57.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="middle">1RM/body mass</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Initial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.98±0.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.0±0.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.3±0.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Final \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.11±0.18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.59±0.36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.81±0.25 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2173410.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Changes in weight, absolute one-repetition maximum and one-repetition maximum/body mass of animals after the resistance training protocol." ] ] 3 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "One-way analysis of variance was used followed by the Bonferroni post hoc test.C: control group; DBP: diastolic blood pressure; HR: heart rate; MAP: mean arterial pressure; SBP: systolic blood pressure; WDRT: Western diet trained group; WDS: Western diet sedentary group." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C (n=7) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">WDS (n=7) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">WDRT (n=7) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HR, bpm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">383.7±12.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">367.2±13.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">354.0±7.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">DBP, mmHg \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">82.8±2.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">99±3.0<a class="elsevierStyleCrossRef" href="#tblfn0010">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">89.1±2.8<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MAP, mmHg \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">103.2±3.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">121.1±2.6<a class="elsevierStyleCrossRef" href="#tblfn0010">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">108.2±3.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SBP, mmHg \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">134.2±5.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">151.5±3.4<a class="elsevierStyleCrossRef" href="#tblfn0010">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">135.2±3.1<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2173409.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "p<0.05 for WDRT vs. WDS." ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "p<0.05 for WDS vs. C." ] ] ] "descripcion" => array:1 [ "en" => "Hemodynamic variables recorded 24 hours after the resistance training protocol." ] ] 4 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "One-way analysis of variance was used followed by the Bonferroni post hoc test.C: control group; HDL: high-density lipoprotein; LDL: low-density lipoprotein; TC: total cholesterol; TG: triglycerides; VLDL: very low-density lipoprotein; WDRT: Western diet trained group; WDS: Western diet sedentary group." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C (n=7) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">WDS (n=7) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">WDRT (n=7) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">70.8±1.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">85.6±3.4<a class="elsevierStyleCrossRef" href="#tblfn0025">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">67.0±3.8<a class="elsevierStyleCrossRef" href="#tblfn0015">a</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Glucose \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">126.2±3.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">153.8±6.3<a class="elsevierStyleCrossRef" href="#tblfn0025">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">116.2±4.6<a class="elsevierStyleCrossRef" href="#tblfn0015">a</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HDL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48.5±0.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41.8±2.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">57.2±3.5<a class="elsevierStyleCrossRef" href="#tblfn0015">a</a>,<a class="elsevierStyleCrossRef" href="#tblfn0020">c</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LDL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.1±0.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">31.0±3.2<a class="elsevierStyleCrossRef" href="#tblfn0025">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14.2±2.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47.4±2.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54.0±2.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">53.2±4.8<a class="elsevierStyleCrossRef" href="#tblfn0020">c</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">VLDL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.1±0.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.0±0.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.4±0.8<a class="elsevierStyleCrossRef" href="#tblfn0015">a</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2173408.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "a" "nota" => "p<0.05 for WDRT vs. WDS." ] 1 => array:3 [ "identificador" => "tblfn0020" "etiqueta" => "c" "nota" => "p<0.05 for WDRT vs. C." ] 2 => array:3 [ "identificador" => "tblfn0025" "etiqueta" => "b" "nota" => "p<0.05 for WDS vs. C." ] ] ] "descripcion" => array:1 [ "en" => "Biochemical variables assessed in blood samples collected 24 hours after the resistance training protocol." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib0195" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Where's the fat? Trends in U.S. Diets 1965–1996" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B.M. Popkin" 1 => "A.M. Siega-Riz" 2 => "P.S. Haines" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1006/pmed.2000.0807" "Revista" => array:6 [ "tituloSerie" => "Prev Med" "fecha" => "2001" "volumen" => "32" "paginaInicial" => "245" "paginaFinal" => "254" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11277682" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0200" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nutritional transition in Brazil: geographic and temporal trends" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Batista Filho" 1 => "A. Rissin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/s0102-311x2003000700019" "Revista" => array:6 [ "tituloSerie" => "Cad Saúde Pública" "fecha" => "2003" "volumen" => "19" "paginaInicial" => "S181" "paginaFinal" => "S191" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12886448" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0205" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.C. Ochoa" 1 => "M.J. Moreno-Aliaga" 2 => "M.A. Martínez-González" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/17477160600650386" "Revista" => array:6 [ "tituloSerie" => "Int J Pediatr Obes" "fecha" => "2006" "volumen" => "1" "paginaInicial" => "83" "paginaFinal" => "88" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17907319" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0210" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Malnutrition: long-term consequences and nutritional recovery effects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.L. Sawaya" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Estud Av" "fecha" => "2006" "volumen" => "20" "paginaInicial" => "147" "paginaFinal" => "158" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0215" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maternal prepregnancy body mass index and their children's blood pressure and resting cardiac autonomic balance at age 5 to 6 years" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.G.J. Gademan" 1 => "M. van Eijsden" 2 => "T.J. Roseboom" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/HYPERTENSIONAHA.113.01511" "Revista" => array:6 [ "tituloSerie" => "Hypertension" "fecha" => "2013" "volumen" => "62" "paginaInicial" => "641" "paginaFinal" => "647" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23876476" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0220" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The origins of the developmental origins theory" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.J.P. Barker" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2796.2007.01809.x" "Revista" => array:6 [ "tituloSerie" => "J Intern Med" "fecha" => "2007" "volumen" => "261" "paginaInicial" => "412" "paginaFinal" => "417" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17444880" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0225" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Developmental and epigenetic pathways to obesity: an evolutionary-developmental perspective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.D. Gluckman" 1 => "M.A. Hanson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Obes" "fecha" => "2008" "volumen" => "32" "paginaInicial" => "S62" "paginaFinal" => "S71" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0230" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Perinatal exposure to high-fat diet programs energy balance, metabolism and behavior in adulthood" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.L. Sullivan" 1 => "M.S. Smith" 2 => "K.L. Grove" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000322038" "Revista" => array:6 [ "tituloSerie" => "Neuroendocrinology" "fecha" => "2011" "volumen" => "93" "paginaInicial" => "1" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21079387" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0235" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Western diet in the perinatal period promotes dysautonomia in the offspring of adult rats" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R. Vidal-Santos" 1 => "F.N. Macedo" 2 => "M.N.S. Santana" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1017/S2040174416000623" "Revista" => array:6 [ "tituloSerie" => "J Dev Orig Health Dis" "fecha" => "2017" "volumen" => "8" "paginaInicial" => "216" "paginaFinal" => "225" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27931267" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0240" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased nitric oxide bioavailability and decreased sympathetic modulation are involved in vascular adjustments induced by low-intensity resistance training" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "F.N. Macedo" 1 => "T.R.R. Mesquita" 2 => "V.U. Melo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3389/fphys.2016.00265" "Revista" => array:4 [ "tituloSerie" => "Front Physiol" "fecha" => "2016" "volumen" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27920726" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0245" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resistance exercise restores endothelial function and reduces blood pressure in type 1 diabetic rats" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.M. Mota" 1 => "T.L.T.B. da Silva" 2 => "M.T. Fontes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5935/abc.20140087" "Revista" => array:6 [ "tituloSerie" => "Arq Bras Cardiol" "fecha" => "2014" "volumen" => "103" "paginaInicial" => "25" "paginaFinal" => "32" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25120082" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0250" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.G. Reeves" 1 => "F.H. Nielsen" 2 => "G.C. Fahey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jn/123.11.1939" "Revista" => array:6 [ "tituloSerie" => "J Nutr" "fecha" => "1993" "volumen" => "123" "paginaInicial" => "1939" "paginaFinal" => "1951" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8229312" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0255" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A weight-lifting exercise model for inducing hypertrophy in the hindlimb muscles of rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T. Tamaki" 1 => "S. Uchiyama" 2 => "S. Nakano" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med Sci Sports Exerc" "fecha" => "1992" "volumen" => "24" "paginaInicial" => "881" "paginaFinal" => "886" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1406173" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0260" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "American College of Sports Medicine position stand. Progression models in resistance training for healthy adults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "American College of Sports Medicine" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1249/MSS.0b013e3181915670" "Revista" => array:7 [ "tituloSerie" => "Med Sci Sports Exerc" "fecha" => "2009" "volumen" => "41" "paginaInicial" => "687" "paginaFinal" => "708" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19204579" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0738399117304081" "estado" => "S300" "issn" => "07383991" ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0265" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ovarian hormone deprivation reduces oxytocin expression in paraventricular nucleus preautonomic neurons and correlates with baroreflex impairment in rats" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "V.U. De Melo" 1 => "R.R.M. Saldanha" 2 => "C.R. Dos Santos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3389/fphys.2016.00557" "Revista" => array:4 [ "tituloSerie" => "Front Physiol" "fecha" => "2016" "volumen" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27920726" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0270" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W.T. Friedewald" 1 => "R.I. Levy" 2 => "D.S. Fredrickson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chem" "fecha" => "1972" "volumen" => "18" "paginaInicial" => "499" "paginaFinal" => "502" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4337382" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0275" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of 14 weeks of resistance training on lipid profile and body fat percentage in premenopausal women" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B. Prabhakaran" 1 => "E.A. Dowling" 2 => "J.D. Branch" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bjsm.33.3.190" "Revista" => array:6 [ "tituloSerie" => "Br J Sports Med" "fecha" => "1999" "volumen" => "33" "paginaInicial" => "190" "paginaFinal" => "195" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10378072" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0280" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efeito de 12 semanas de treinamento com pesos sobre a força muscular, composição corporal e triglicérides em homens sedentários" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.D. Polito" 1 => "E.S. Cyrino" 2 => "A.M. Gerage" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Bras Med Esporte" "fecha" => "2010" "volumen" => "16" "paginaInicial" => "29" "paginaFinal" => "32" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0285" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of changing levels of physical activity on blood-pressure and haemodynamics in essential hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Nelson" 1 => "G.L. Jennings" 2 => "M.D. Esler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet Lond Engl" "fecha" => "1986" "volumen" => "2" "paginaInicial" => "473" "paginaFinal" => "476" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0290" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exercise training normalizes wall-to-lumen ratio of the gracilis muscle arterioles and reduces pressure in spontaneously hypertensive rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.L. Amaral" 1 => "T.M.T. Zorn" 2 => "L.C. Michelini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/00004872-200018110-00006" "Revista" => array:7 [ "tituloSerie" => "J Hypertens" "fecha" => "2000" "volumen" => "18" "paginaInicial" => "1563" "paginaFinal" => "1572" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11081768" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1525505015001201" "estado" => "S300" "issn" => "15255050" ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0295" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.S. Véras-Silva" 1 => "K.C. Mattos" 2 => "N.S. Gava" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Physiol – Heart Circ Physiol" "fecha" => "1997" "volumen" => "273" "paginaInicial" => "H2627" "paginaFinal" => "H2631" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0300" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exercise and endothelial function: role of endothelium-derived nitric oxide and oxidative stress in healthy subjects and hypertensive patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Y. Higashi" 1 => "M. Yoshizumi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.pharmthera.2004.02.003" "Revista" => array:6 [ "tituloSerie" => "Pharmacol Ther" "fecha" => "2004" "volumen" => "102" "paginaInicial" => "87" "paginaFinal" => "96" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15056500" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0305" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exercise training-induced remodeling of paraventricular nucleus (nor)adrenergic innervation in normotensive and hypertensive rats" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K.T. Higa-Taniguchi" 1 => "F.C.P. Silva" 2 => "H.M.V. Silva" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/ajpregu.00613.2006" "Revista" => array:6 [ "tituloSerie" => "Am J Physiol – Regul Integr Comp Physiol" "fecha" => "2007" "volumen" => "292" "paginaInicial" => "R1717" "paginaFinal" => "R1727" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17218443" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0310" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The NTS and integration of cardiovascular control during exercise in normotensive and hypertensive individuals" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L.C. Michelini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11906-007-0039-x" "Revista" => array:6 [ "tituloSerie" => "Curr Hypertens Rep" "fecha" => "2007" "volumen" => "9" "paginaInicial" => "214" "paginaFinal" => "221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17519128" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0315" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exercise training differentially affects intrinsic excitability of autonomic and neuroendocrine neurons in the hypothalamic paraventricular nucleus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K. Jackson" 1 => "H.M.V. Silva" 2 => "W. Zhang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/jn.00277.2005" "Revista" => array:6 [ "tituloSerie" => "J Neurophysiol" "fecha" => "2005" "volumen" => "94" "paginaInicial" => "3211" "paginaFinal" => "3220" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16049146" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0320" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypertension and exercise training differentially affect oxytocin and oxytocin receptor expression in the brain" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.S. Martins" 1 => "A. Crescenzi" 2 => "J.E. Stern" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.HYP.0000175812.03322.59" "Revista" => array:6 [ "tituloSerie" => "Hypertension" "fecha" => "2005" "volumen" => "46" "paginaInicial" => "1004" "paginaFinal" => "1009" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16157794" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0325" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Baroreflex control of heart rate by oxytocin in the solitary-vagal complex" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K.T. Higa" 1 => "E. Mori" 2 => "F.F. Viana" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/ajpregu.00806.2000" "Revista" => array:6 [ "tituloSerie" => "Am J Physiol – Regul Integr Comp Physiol" "fecha" => "2002" "volumen" => "282" "paginaInicial" => "R537" "paginaFinal" => "R545" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11792664" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0330" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity-associated hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K. Rahmouni" 1 => "M.L.G. Correia" 2 => "W.G. Haynes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.HYP.0000151325.83008.b4" "Revista" => array:7 [ "tituloSerie" => "Hypertension" "fecha" => "2005" "volumen" => "45" "paginaInicial" => "9" "paginaFinal" => "14" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15583075" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1059131116303247" "estado" => "S300" "issn" => "10591311" ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0335" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Arterial baroreflex modulation of sympathetic activity and arterial wall properties" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Parati" 1 => "G. Bilo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/HYPERTENSIONAHA.111.182766" "Revista" => array:6 [ "tituloSerie" => "Hypertension" "fecha" => "2012" "volumen" => "59" "paginaInicial" => "5" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22106402" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0340" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute and chronic effects of resistive exercise on blood pressure in hypertensive elderly women" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.R. Mota" 1 => "R.J. de Oliveira" 2 => "M.T. Dutra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1519/JSC.0b013e31828f2766" "Revista" => array:7 [ "tituloSerie" => "J Strength Cond Res" "fecha" => "2013" "volumen" => "27" "paginaInicial" => "3475" "paginaFinal" => "3480" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23478476" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1525505015004837" "estado" => "S300" "issn" => "15255050" ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0345" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resistance exercise acutely enhances mesenteric artery insulin-induced relaxation in healthy rats" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.T. Fontes" 1 => "T.L.B.T. Silva" 2 => "M.M. Mota" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.lfs.2013.11.017" "Revista" => array:6 [ "tituloSerie" => "Life Sci" "fecha" => "2014" "volumen" => "94" "paginaInicial" => "24" "paginaFinal" => "29" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24316143" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0350" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early exposure of dams to a westernized diet has long-term consequences on food intake and physiometabolic homeostasis of the rat offspring" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "T.C.F. Cavalcante" 1 => "A.A.M. da Silva" 2 => "M.C.A. Lira" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/09637486.2014.950208" "Revista" => array:6 [ "tituloSerie" => "Int J Food Sci Nutr" "fecha" => "2014" "volumen" => "65" "paginaInicial" => "989" "paginaFinal" => "993" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25198159" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0355" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "GLUT4 protein expression in obese and lean 12-month-old rats: insights from different types of data analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.M. Seraphim" 1 => "M.T. Nunes" 2 => "U.F. Machado" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/s0100-879x2001001000018" "Revista" => array:7 [ "tituloSerie" => "Braz J Med Biol Res" "fecha" => "2001" "volumen" => "34" "paginaInicial" => "1353" "paginaFinal" => "1362" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11593313" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0733861909000474" "estado" => "S300" "issn" => "07338619" ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0360" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.K. Holten" 1 => "M. Zacho" 2 => "M. Gaster" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2337/diabetes.53.2.294" "Revista" => array:6 [ "tituloSerie" => "Diabetes" "fecha" => "2004" "volumen" => "53" "paginaInicial" => "294" "paginaFinal" => "305" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14747278" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0365" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C. Castaneda" 1 => "J.E. Layne" 2 => "L. Munoz-Orians" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2337/diacare.25.12.2335" "Revista" => array:6 [ "tituloSerie" => "Diabetes Care" "fecha" => "2002" "volumen" => "25" "paginaInicial" => "2335" "paginaFinal" => "2341" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12453982" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0370" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exercise training and blood lipids in hyperlipidemic and normolipidemic adults: a meta-analysis of randomized, controlled trials" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.A. Halbert" 1 => "C.A. Silagy" 2 => "P. Finucane" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.ejcn.1600784" "Revista" => array:7 [ "tituloSerie" => "Eur J Clin Nutr" "fecha" => "1999" "volumen" => "53" "paginaInicial" => "514" "paginaFinal" => "522" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10452405" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1059131115002149" "estado" => "S300" "issn" => "10591311" ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0375" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of strength and endurance training on insulin sensitivity and fat distribution in human immunodeficiency virus-infected patients with lipodystrophy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B. Lindegaard" 1 => "T. Hansen" 2 => "T. Hvid" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jc.2007-2733" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2008" "volumen" => "93" "paginaInicial" => "3860" "paginaFinal" => "3869" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18628529" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0380" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Conditional risk factors for atherosclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I.J. Kullo" 1 => "C.M. Ballantyne" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4065/80.2.219" "Revista" => array:7 [ "tituloSerie" => "Mayo Clin Proc" "fecha" => "2005" "volumen" => "80" "paginaInicial" => "219" "paginaFinal" => "230" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15704777" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1059131116303223" "estado" => "S300" "issn" => "10591311" ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack436056" "titulo" => "Acknowledgments" "texto" => "We thank the Coordination for the Improvement of Higher Education Personnel (CAPES) and the Foundation for Scientific and Technological Research of Sergipe (FAPITEC)." "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/21742049/0000003800000005/v2_201911300820/S2174204919301497/v2_201911300820/en/main.assets" "Apartado" => array:4 [ "identificador" => "9917" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21742049/0000003800000005/v2_201911300820/S2174204919301497/v2_201911300820/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204919301497?idApp=UINPBA00004E"]

Statistics

Original Article

Resistance training improves cardiovascular autonomic control and biochemical profile of rats exposed to a Western diet in the perinatal period

Treinamento resistido melhora controle autonômico cardiovascular e perfil bioquímico de ratos expostos a dieta ocidental no período perinatal

Michael Nadson Santos Santana, Vitor Ulisses De Melo, Fabricio Nunes Macedo, André Sales Barreto, Robervan Vidal-Santos, Matiotti Neto, Marcio Roberto Viana dos Santos, Valter Joviniano Santana-Filho

Corresponding author

vjsf@infonet.com.br

Corresponding author.

Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil

Read

3560

Times
was read the article

1579

Total PDF

1981

Total HTML

Share statistics

 array:25 [
  "pii" => "S2174204919301497"
  "issn" => "21742049"
  "doi" => "10.1016/j.repce.2018.08.008"
  "estado" => "S300"
  "fechaPublicacion" => "2019-05-01"
  "aid" => "1384"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2019"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Cardiol. 2019;38:337-45"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 340
    "formatos" => array:3 [
      "EPUB" => 52
      "HTML" => 166
      "PDF" => 122
    ]
  ]
  "Traduccion" => array:1 [
    "pt" => array:20 [
      "pii" => "S0870255118300751"
      "issn" => "08702551"
      "doi" => "10.1016/j.repc.2018.08.009"
      "estado" => "S300"
      "fechaPublicacion" => "2019-05-01"
      "aid" => "1384"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Rev Port Cardiol. 2019;38:337-45"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 535
        "formatos" => array:3 [
          "EPUB" => 50
          "HTML" => 286
          "PDF" => 199
        ]
      ]
      "pt" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original</span>"
        "titulo" => "Treinamento resistido melhora controle auton&#244;mico cardiovascular e perfil bioqu&#237;mico de ratos expostos a dieta ocidental no per&#237;odo perinatal"
        "tienePdf" => "pt"
        "tieneTextoCompleto" => "pt"
        "tieneResumen" => array:2 [
          0 => "pt"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "337"
            "paginaFinal" => "345"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Resistance training improves cardiovascular autonomic control and biochemical profile of rats exposed to Western diet in the perinatal period"
          ]
        ]
        "contieneResumen" => array:2 [
          "pt" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "pt" => true
        ]
        "contienePdf" => array:1 [
          "pt" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2625
                "Ancho" => 2463
                "Tamanyo" => 168092
              ]
            ]
            "descripcion" => array:1 [
              "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Modula&#231;&#227;o auton&#244;mica cardiovascular e sensibilidade espont&#226;nea do barorreflexo ap&#243;s quatro semanas de TR&#46; C&#58; grupo controle&#59; OCS&#58; grupo dieta ocidental sedent&#225;rio&#59; OCTR&#58; grupo dieta ocidental treinado&#59; HF&#58; <span class="elsevierStyleItalic">high frequency</span>&#59; LF&#58; <span class="elsevierStyleItalic">low frequency</span>&#59; Lfsys&#58; LF da press&#227;o arterial&#59; SBR&#58; sensibilidade do barorreflexo&#46;&#42;p &#60; 0&#44;05&#58; OCTR <span class="elsevierStyleItalic">vs</span> OCS&#59; <span class="elsevierStyleSup">&#35;</span>p &#60; 0&#44;05&#58; OCTR <span class="elsevierStyleItalic">vs</span> C&#59; <span class="elsevierStyleSup">&#167;</span>p &#60; 0&#44;05&#58; OCS <span class="elsevierStyleItalic">vs</span> C&#46; Foi utilizado o teste Anova de uma via&#44; seguido por p&#243;s&#8208;teste de Bonferroni&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Michael Nadson Santos Santana, Vitor Ulisses De Melo, Fabricio Nunes Macedo, Andr&#233; Sales Barreto, Robervan Vidal&#8208;Santos, Mario Matiotti Neto, Marcio Roberto Viana dos Santos, Valter Joviniano Santana&#8208;Filho"
            "autores" => array:8 [
              0 => array:2 [
                "nombre" => "Michael Nadson Santos"
                "apellidos" => "Santana"
              ]
              1 => array:2 [
                "nombre" => "Vitor Ulisses"
                "apellidos" => "De Melo"
              ]
              2 => array:2 [
                "nombre" => "Fabricio Nunes"
                "apellidos" => "Macedo"
              ]
              3 => array:2 [
                "nombre" => "Andr&#233; Sales"
                "apellidos" => "Barreto"
              ]
              4 => array:2 [
                "nombre" => "Robervan"
                "apellidos" => "Vidal&#8208;Santos"
              ]
              5 => array:2 [
                "nombre" => "Mario"
                "apellidos" => "Matiotti Neto"
              ]
              6 => array:2 [
                "nombre" => "Marcio Roberto Viana dos"
                "apellidos" => "Santos"
              ]
              7 => array:2 [
                "nombre" => "Valter Joviniano"
                "apellidos" => "Santana&#8208;Filho"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "pt"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2174204919301539"
          "doi" => "10.1016/j.repce.2019.06.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204919301539?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255118300751?idApp=UINPBA00004E"
      "url" => "/08702551/0000003800000005/v3_201911281014/S0870255118300751/v3_201911281014/pt/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2174204919301539"
    "issn" => "21742049"
    "doi" => "10.1016/j.repce.2019.06.003"
    "estado" => "S300"
    "fechaPublicacion" => "2019-05-01"
    "aid" => "1397"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "dis"
    "cita" => "Rev Port Cardiol. 2019;38:347-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 260
      "formatos" => array:3 [
        "EPUB" => 42
        "HTML" => 135
        "PDF" => 83
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
      "titulo" => "Heartfelt exercise&#58; Physical exercise gets the cardiovascular system into shape"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "347"
          "paginaFinal" => "348"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Sistema cardiovascular em forma com exerc&#237;cio f&#237;sico"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Frederico C&#46; Pereira"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Frederico"
              "apellidos" => "C&#46; Pereira"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:2 [
      "pt" => array:9 [
        "pii" => "S0870255118300751"
        "doi" => "10.1016/j.repc.2018.08.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255118300751?idApp=UINPBA00004E"
      ]
      "en" => array:9 [
        "pii" => "S0870255119303385"
        "doi" => "10.1016/j.repc.2019.06.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255119303385?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204919301539?idApp=UINPBA00004E"
    "url" => "/21742049/0000003800000005/v2_201911300820/S2174204919301539/v2_201911300820/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2174204919301564"
    "issn" => "21742049"
    "doi" => "10.1016/j.repce.2019.06.006"
    "estado" => "S300"
    "fechaPublicacion" => "2019-05-01"
    "aid" => "1396"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "dis"
    "cita" => "Rev Port Cardiol. 2019;38:333-5"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 427
      "formatos" => array:3 [
        "EPUB" => 58
        "HTML" => 265
        "PDF" => 104
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
      "titulo" => "Metabolic syndrome and cardiovascular risk"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "333"
          "paginaFinal" => "335"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "S&#237;ndrome metab&#243;lica e risco cardiovascular"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Evangelista Rocha"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Evangelista"
              "apellidos" => "Rocha"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:2 [
      "pt" => array:9 [
        "pii" => "S0870255118300696"
        "doi" => "10.1016/j.repc.2018.06.012"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255118300696?idApp=UINPBA00004E"
      ]
      "en" => array:9 [
        "pii" => "S0870255119303373"
        "doi" => "10.1016/j.repc.2019.06.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255119303373?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204919301564?idApp=UINPBA00004E"
    "url" => "/21742049/0000003800000005/v2_201911300820/S2174204919301564/v2_201911300820/en/main.assets"
  ]
  "en" => array:22 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
    "titulo" => "Resistance training improves cardiovascular autonomic control and biochemical profile of rats exposed to a Western diet in the perinatal period"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "337"
        "paginaFinal" => "345"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Michael Nadson Santos Santana, Vitor Ulisses De Melo, Fabricio Nunes Macedo, Andr&#233; Sales Barreto, Robervan Vidal-Santos, Matiotti Neto, Marcio Roberto Viana dos Santos, Valter Joviniano Santana-Filho"
        "autores" => array:8 [
          0 => array:2 [
            "nombre" => "Michael Nadson Santos"
            "apellidos" => "Santana"
          ]
          1 => array:2 [
            "nombre" => "Vitor Ulisses"
            "apellidos" => "De Melo"
          ]
          2 => array:2 [
            "nombre" => "Fabricio Nunes"
            "apellidos" => "Macedo"
          ]
          3 => array:2 [
            "nombre" => "Andr&#233; Sales"
            "apellidos" => "Barreto"
          ]
          4 => array:2 [
            "nombre" => "Robervan"
            "apellidos" => "Vidal-Santos"
          ]
          5 => array:2 [
            "nombre" => "Matiotti"
            "apellidos" => "Neto"
          ]
          6 => array:2 [
            "nombre" => "Marcio Roberto Viana"
            "apellidos" => "dos Santos"
          ]
          7 => array:4 [
            "nombre" => "Valter Joviniano"
            "apellidos" => "Santana-Filho"
            "email" => array:1 [
              0 => "vjsf@infonet.com.br"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Departamento de Fisiologia&#44; Universidade Federal de Sergipe&#44; S&#227;o Crist&#243;v&#227;o&#44; SE&#44; Brazil"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Treinamento resistido melhora controle auton&#244;mico cardiovascular e perfil bioqu&#237;mico de ratos expostos a dieta ocidental no per&#237;odo perinatal"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1237
            "Ancho" => 3167
            "Tamanyo" => 174812
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Experimental design&#58; mating&#44; beginning of experimental diets&#44; resistance training &#40;RT&#41; protocol and recording of cardiovascular variables&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Introduction</span><p id="par0125" class="elsevierStylePara elsevierViewall">Eating patterns in the modern world are changing&#44; with increasing consumption of low-cost&#44; high-calorie&#44; processed foods high in sodium and saturated fat and low in other essential nutrients&#46; This is known as the Western diet&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">1&#44;2</span></a> At the same time&#44; technological advances and modern lifestyles have reduced the need for people to move&#44; resulting in increased sedentarism&#46; These factors are leading to increases in overweight and obesity&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">3</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Studies show that excessive consumption of nutrients in early life &#40;intrauterine and&#47;or pre- and post-natal stages&#41; leads to morphological and functional changes in the fetus and to the development of cardiovascular disease in adulthood&#44; in both animals<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">4</span></a> and humans&#44;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">5</span></a> a phenomenon known as fetal or metabolic programming&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">This process can alter phenotypic characteristics&#44; leading to dysregulation of energy balances and to gains in body weight&#44; predisposing the individual to obesity and associated comorbidities&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">8&#44;9</span></a> In a previous study&#44; we showed that animals fed a Western diet in the perinatal period had altered biochemical profiles and cardiovascular dysautonomia&#44; followed by hypertension in adulthood&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">9</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">Resistance training &#40;RT&#41; is used as a way to improve physical and muscular fitness&#44; increase lean mass and maintain basal metabolic rate&#46; RT has also been shown to foster beneficial adaptations in cardiovascular function&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">10&#44;11</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">We therefore hypothesized that the cardiovascular benefits of RT are brought about by adaptations in blood pressure &#40;BP&#41; control mechanisms and that it will improve the biochemical profile of rats exposed to a Western diet in the perinatal period&#46; Accordingly&#44; the study aimed to observe the effects of RT on cardiovascular and biochemical variables in these animals&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Animals</span><p id="par0150" class="elsevierStylePara elsevierViewall">The present study meets the standards for conducting research on animals and its procedures followed the ethical principles of animal experimentation laid down by the Brazilian National Council for the Control of Animal Experimentation &#40;CONCEA&#41;&#44; based on the 2013 Brazilian guidelines for the care and use of animals for scientific and teaching purposes &#40;DBCA&#41;&#46; It was approved by the Committee on Animal Research and Ethics of the Federal University of Sergipe &#40;CEPA&#47;UFS&#41;&#44; protocol 10&#47;2014&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Wistar rats of both sexes were kept in polypropylene cages with water and chow ad libitum at a temperature of 22&#177;1 &#176;C&#46; Fifteen virgin female Wistar rats&#44; aged between 90 and 120 days and weighing 250-300 g&#44; were mated with fertile males in the proportion of four females to one male&#46; A vaginal swab was used daily to check for pregnancy from the presence of sperm&#46; The female rats were then divided into two groups according to diet&#58; Control &#40;n&#61;5&#41; and Western &#40;n&#61;5&#41;&#44; until weaning&#46; The litters were each adjusted to eight neonates 24 hours after birth&#44; maintaining the same proportion of males and females when possible&#46; Only males were used in the experimental protocols&#44; to prevent the hormonal fluctuations due to the estrous cycle from influencing the results&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">After weaning&#44; the pups were divided into three groups&#58; Control &#40;C&#44; n&#61;7&#41;&#44; pups of mothers fed a control diet that did not perform RT&#59; Western diet sedentary &#40;WDS&#44; n&#61;7&#41;&#44; pups of mothers fed with a Western diet that did not perform RT&#59; and Western diet trained &#40;WDRT&#44; n&#61;7&#41;&#44; pups of mothers fed with a Western diet that performed RT&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">After weaning&#44; the animals were fed with Labina&#174; commercial chow for rodents&#46; According to the manufacturer &#40;Purina do Brasil Ltda&#41;&#44; the chow contains minimum 23&#37; crude protein&#44; minimum 4&#37; volatile substances&#44; maximum 10&#37; ash and 5&#37; fiber&#44; and has an energy content of 3&#46;6 kcal&#47;g&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Diets</span><p id="par0170" class="elsevierStylePara elsevierViewall">The control diet used during gestation and lactation was casein-based AIN-93G&#44; specifically for growing rodents&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">12</span></a> The formulation of the experimental Western diet was based on the Brazilian Household Budget Survey &#40;HBS&#41;&#44; with some adjustments to the percentages of its composition&#46; These included increased lipid and simple carbohydrate content in order to enhance organoleptic factors&#44; to give the feed a similarly pleasant odor and texture to the Western diet&#46; The protein content was also adjusted&#44; since the proportion of protein in the HBS diet is inadequate for the reproduction and growth stages in rats&#44; and a final adjustment was made for the adult rats&#8217; maintenance stage &#40;15&#46;5&#37; protein&#41;&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">The Western diet contained 31&#37; lipids&#44; mainly saturated fats &#40;67&#46;59&#37;&#41;&#44; and 51&#46;7&#37; carbohydrates&#44; mainly in the form of simple sugars&#44; which resembles Western diets in humans&#44; while the control diet contained 25&#46;99&#37; saturated fats and 55&#37; carbohydrates&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">The Control &#40;AIN-93G&#41; and Western diets were produced by the Laboratory of Experimental Nutrition and Diet &#40;LNED&#41; of the Department of Nutrition of the Federal University of Pernambuco and were stored at 4 &#176;C until used&#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Resistance training protocol</span><p id="par0185" class="elsevierStylePara elsevierViewall">RT was performed using a squat-training apparatus&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">13</span></a> The animals underwent a five-day adaptation period before training by being handled and placed in the device in the starting position of the exercise&#44; with no added load&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">After adaptation&#44; all the animals underwent a one-repetition maximum test &#40;1RM&#41; to determine the loads to be used&#46; In the 1RM&#44; the animal fully extends its hind legs under the maximum possible load while completing the movement&#46; The desired intensity can thus be calculated based on the loads raised in the test&#46; The RT protocol started after 48 hours&#44; and consisted of three series of 10 repetitions with an intensity of 40&#37; of 1RM &#40;defined as low intensity&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">14</span></a> with 1-min intervals between the series for recovery&#46; Each RT session lasted approximately 5 min&#46; RT was performed five times a week for four weeks&#44; for a total of 20 RT sessions&#46; A new 1RM was carried out every 15 days to adjust the loads&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">The animals were stimulated to perform the exercise by electrodes placed on the tail &#40;BIOSET&#44; Physiotonus four&#44; Model 3050&#44; Rio Claro&#44; S&#227;o Paulo&#41;&#46; The parameters used were frequency 1 Hz&#44; pulse width 1 ms&#44; on time 1-3 s&#44; off time 2 s&#44; and sufficient intensity for the animals to perform the exercise &#40;4-15 mA&#41;&#46; The animals in groups C and WDS were placed in the squat-training apparatus and electrostimulated with the same parameters as for those in the WDRT group&#44; but the equipment was kept in the rest position and without added load&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Experimental design</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Assessment of cardiovascular function</span><p id="par0200" class="elsevierStylePara elsevierViewall">The animals were anesthetized with intraperitoneal &#40;IP&#41; sodium thiopental &#40;50 mg&#47;kg&#41; and a polyethylene catheter &#40;PE-10&#47;PE-50&#44; Intramedic&#44; Becton Dickinson&#44; Sparks&#44; MD&#44; USA&#41; was surgically implanted in the left femoral artery&#46; The catheter was exteriorized subcutaneously in the posterior cervical region&#46; After surgery&#44; the animals received 1&#46;1 mg&#47;kg IP of flunixin meglumine &#40;Banamine&#174;&#44; Schering-Plough&#44; Kenilworth&#44; NJ&#44; USA&#41; to reduce hyperalgia and postoperative inflammation&#44; for the animals&#8217; well-being&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Twenty-four hours after the procedure and after recovery from the effects of the anesthesia&#44; the catheter was connected to a pressure transducer coupled to a pre-amplifier &#40;FE221&#44; Bridge Amp&#44; ADInstruments&#44; Bella Vista&#44; NSW&#44; Australia&#41; using the PowerLab recording system &#40;ADInstruments&#44; Bella Vista&#44; NSW&#44; Australia&#41;&#46; BP was recorded for 30 min and processed using LabChart 7 software &#40;ADInstruments&#44; Bella Vista&#44; NSW&#44; Australia&#41;&#44; in order to identify inflection points and to generate beat-by-beat time series&#46; All readings were taken in the morning&#44; in order to ensure that behavioral factors would influence all the animals equally&#46; Mean arterial pressure &#40;MAP&#41;&#44; systolic BP &#40;SBP&#41;&#44; diastolic BP &#40;DBP&#41;&#44; pulse interval &#40;PI&#41; and heart rate &#40;HR&#41; were measured and analyzed&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Autonomic assessment</span><p id="par0210" class="elsevierStylePara elsevierViewall">Variability in PI and SBP was analyzed using CardioSeries software&#44; version 2&#46;4 &#40;<a href="http://sites.google.com/site/cardioseries">http&#58;&#47;&#47;sites&#46;google&#46;com&#47;site&#47;cardioseries</a>&#41;&#44; as described previously&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">15</span></a> Beat-by-beat series were obtained based on the BP recordings and converted into 100-ms points &#40;10 Hz&#41; by cubic spline interpolation&#46; The data were divided into partially overlapping sequences and periods of 512 points &#40;51&#46;2 s&#41;&#46; For calculation of spectral power&#44; the data were inspected visually and non-stationary segments were discarded&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">The spectrum was calculated directly by fast Fourier transform and a Hanning window was used to attenuate distortion&#46; The spectrum was divided into low frequency &#40;LF&#41; &#40;0&#46;2-0&#46;75 Hz&#41; and high frequency &#40;HF&#41; &#40;0&#46;75-3 Hz&#41; bands&#46; The results were expressed in normalized units by dividing the LF and HF powers by the total power minus very low frequency &#40;VLF&#41; &#40;&#60;0&#46;2 Hz&#41; power&#46; The LF component of PI represents cardiac sympathetic modulation&#44; the HF component of PI is an index of vagal modulation&#44; while the LF&#47;HF ratio measures cardiac autonomic balance&#46; The LF component of SBP represents vascular sympathetic modulation&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Spontaneous baroreflex sensitivity &#40;BRS&#41; was quantified by the sequence method&#46; The CardioSeries software was used to process beat-by-beat time series for SBP and PI&#44; searching for sequences of at least four consecutive beats in which increases in SBP were followed by lengthening of PI and decreases in SBP were followed by shortening of PI&#46; Data with a linear correlation of &#62;0&#46;85 were considered to be baroreflex sequences&#46; The slope of the linear regression lines between SBP and PI was used as an index of BRS&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">15</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Biochemical assessment</span><p id="par0225" class="elsevierStylePara elsevierViewall">The animals were anesthetized with halothane after 12 hours fasting&#44; and blood was collected from the retro-orbital plexus using heparinized capillary tubes&#46; The sample was placed in a separation tube and centrifuged at 3500 rpm for 5 min to obtain plasma&#46; The supernatant was drawn off using a pipette and transferred to an Eppendorf&#174; tube&#44; which was sent for biochemical analysis of glucose&#44; total cholesterol &#40;TC&#41;&#44; triglycerides &#40;TG&#41;&#44; high-density lipoprotein &#40;HDL&#41; and low-density lipoprotein &#40;LDL&#41;&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">A colorimetric enzyme assay &#40;Bioclin&#44; Belo Horizonte&#44; Minas Gerais&#44; Brazil&#41; was used to measure plasma concentrations of the biochemical parameters&#44; which were analyzed in an 800 XI spectrophotometer &#40;Femto&#44; S&#227;o Paulo&#44; Brazil&#41;&#44; in accordance with the manufacturer&#39;s instructions&#46; The Friedewald formula was used to measure LDL and very low density lipoprotein &#40;VLDL&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">16</span></a></p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Statistical analysis</span><p id="par0235" class="elsevierStylePara elsevierViewall">Values were reported as mean &#177; standard error of the mean&#46; The results for hemodynamic assessment&#44; autonomic modulation and biochemical profile were analyzed using one-way analysis of variance followed by the Bonferroni post hoc test to assess differences between means in the two groups&#46; Values of p&#60;0&#46;05 were considered statistically significant&#46; GraphPad software version 5&#46;0 &#40;San Diego&#44; CA&#44; USA&#41; was used for the statistical analysis&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Results</span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Changes in body weight and one-repetition maximum test results</span><p id="par0240" class="elsevierStylePara elsevierViewall">After four weeks of RT&#44; no significant difference was observed in the pups&#8217; body mass &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Although the groups fed the Western diet had greater body mass before training&#44; there was also no significant difference in the strength of the animals in the WDRT group compared to those in groups C and WDS&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Hemodynamic assessment</span><p id="par0245" class="elsevierStylePara elsevierViewall">Hemodynamic variables are presented in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; The WDS group had higher BP at rest than groups C and WDRT&#44; while the WDRT group had lower MAP&#44; SBP and DBP than the WDS group&#46; There were no differences in HR between the groups&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Cardiovascular autonomic modulation</span><p id="par0250" class="elsevierStylePara elsevierViewall">The results for autonomic modulation are shown in <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#46; The WDS group presented an increase in the LF component &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>a&#41; and a reduction in HF &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>b&#41;&#46; RT attenuated this alteration&#44; producing a reduction in LF and an increase in HF &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>c&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0255" class="elsevierStylePara elsevierViewall">In addition&#44; the high LF component of SBP had high values in the WDS group&#44; while for WDRT animals this variable was low &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>d&#41;&#46; Although BRS was unchanged as a result of the Western diet&#44; there was an increase in BRS in animals in the WDRT group &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>e&#41; compared to the WDS group&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Biochemical variables</span><p id="par0260" class="elsevierStylePara elsevierViewall">The results for the biochemical variables of fasting blood glucose&#44; TC&#44; HDL&#44; LDL&#44; VLDL and TG can be observed in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46; The WDS group had higher fasting blood glucose&#44; TC and LDL than group C&#44; whereas the WDRT group had lower blood glucose&#44; TC and LDL and higher HDL&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Discussion</span><p id="par0265" class="elsevierStylePara elsevierViewall">The results of the present study show that a Western diet fed to Wistar rats during the perinatal period had important physiological effects&#44; including increased serum glucose&#44; TC&#44; and LDL and reduced HDL&#46; The Western diet also led to dysautonomia&#44; promoting cardiovascular sympathetic modulation and hypertension in adulthood&#46; These findings corroborate previous results from our laboratory using the same experimental protocol and diet&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">9</span></a></p><p id="par0270" class="elsevierStylePara elsevierViewall">Low-intensity RT &#40;40&#37; of 1RM&#41; does not lead to alterations in body mass or strength gain&#44; although individuals on fitness programs show changes in body composition&#46;<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">17&#44;18</span></a> The American College of Sports Medicine &#40;ACSM&#41;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">14</span></a> recommend&#44; in RT programs aimed at increasing muscle strength&#44; loads corresponding to 60-70&#37; of 1RM for novice to intermediate individuals and 80-100&#37; of 1RM for advanced individuals&#46; Programs designed for increasing muscular hypertrophy should use loads of 70-85&#37; of 1RM for novice and intermediate individuals and 70-100&#37; for advanced training&#46; Bara&#250;na et al&#46; observed increased muscle strength in mice trained on apparatus similar to that used in our study&#44; although using workloads of 75&#37; of 1RM&#44; supporting the ACSM&#39;s recommendations&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">14</span></a> Our results show that the intensity and duration of RT used in the present study did not lead to modifications in body mass or strength in these animals&#46;</p><p id="par0275" class="elsevierStylePara elsevierViewall">To our knowledge&#44; this is the first study to show that low-intensity RT reduces sympathetic modulation&#44; increases BRS and improves the lipid and glycemic profiles of animals exposed to a Western diet in the perinatal period&#44; which did not develop the hypertension observed in sedentary animals on the same diet&#46; Animals exposed to a Western diet and to RT presented lower BP and improvements in most biochemical variables&#46; RT improved BRS&#44; without increasing the LF component but increasing the HF component of PI&#46; The mechanisms behind this effect may be associated with adjustments in central BP control mechanisms&#46;</p><p id="par0280" class="elsevierStylePara elsevierViewall">Physical exercise has been associated with various cardiovascular adaptations&#44; including reduced vascular resistance&#44;<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">19&#44;20</span></a> cardiac remodeling&#44; lower blood pressure&#44; reduced HR<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">21</span></a> and increased expression of endothelium-derived relaxing factors&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">22</span></a></p><p id="par0285" class="elsevierStylePara elsevierViewall">It has been shown that aerobic exercise induces neural changes in autonomic nuclei&#44; increasing noradrenergic signaling from the nucleus of the solitary tract &#40;NST&#41; to pre-autonomic neurons in the paraventricular nucleus &#40;PVN&#41; of the hypothalamus&#44; increasing the intrinsic excitability of neurons in the PVN-NST pathway&#44; and increasing vagal tone through the release of acetylcholine by the vagus nerve&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">23&#44;24</span></a> The same training model leads to an increase in mRNA of the oxytocin receptor in the medulla and greater expression of this neurotransmitter in the PVN&#44;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">23&#44;25&#44;26</span></a> which correlates with improvement in baroreflex control&#46;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">24&#44;27</span></a> These adjustments may help to reduce sympathetic tone in hypertensive subjects&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">23</span></a></p><p id="par0290" class="elsevierStylePara elsevierViewall">We observed that RT also led to beneficial adaptations in the cardiovascular system&#44; including lower BP&#44; increased BRS and improvement in sympathovagal balance&#44; corroborating previous findings by our group&#44;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">10</span></a> although the mechanisms involved in these responses remain to be elucidated&#46;</p><p id="par0295" class="elsevierStylePara elsevierViewall">Sedentary animals that consumed a Western diet at the start of life presented increased vascular sympathetic modulation&#44; as observed in a previous study carried out in our laboratory&#44;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">9</span></a> while this variable decreased in the group that performed RT&#46; The consumption of high-calorie and high-fat diets is directly related to increases in adipose tissue and obesity&#44; which leads to sympathetic hyperactivity&#44; promoting peripheral vasoconstriction and hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">28</span></a> There is evidence that reduced sympathetic action in blood vessels helps to decrease BP&#44; mediated by changes in vascular stiffness&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">29</span></a></p><p id="par0300" class="elsevierStylePara elsevierViewall">Previous studies carried out in our laboratory using the same exercise model showed that RT enhances acetylcholine- and insulin-induced vasodilation&#44; increases the bioavailability of nitric oxide&#44; and improves sympathovagal balance and vasodilation capacity&#46; Collectively&#44; these factors help reduce BP&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">10&#44;30&#8211;32</span></a></p><p id="par0305" class="elsevierStylePara elsevierViewall">The nutritional insult induced in the animals at the start of life caused metabolic disorders&#44; with increases in TC&#44; LDL and blood glucose&#44; as previously observed&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">9&#44;33</span></a> In models of obesity&#44; insulin resistance is associated with reduced expression of glucose transporter 4 &#40;GLUT4&#41; and impairment of the insulin signaling pathway&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">34</span></a> RT increases the expression of GLUT4&#44; improving insulin response in skeletal muscle and adipose tissue&#46;<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">32&#44;35&#44;36</span></a> The reduction in blood glucose observed in this study probably results from improved glucose transportation through GLUT4 translocation&#46;</p><p id="par0310" class="elsevierStylePara elsevierViewall">The trained rats exposed to a Western diet had lower LDL&#44; corroborating studies in which RT reduced this variable in different populations&#46;<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">37&#44;38</span></a> Higher serum lipid concentrations increase arterial fat deposits and impair vascular elasticity caused by LDL deposition&#44; which may evolve to atherosclerosis&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">39</span></a></p><p id="par0315" class="elsevierStylePara elsevierViewall">No change was noted in HDL as a result of the consumption of the Western diet&#46; However&#44; the trained animals showed an increase in HDL&#44; which helps to protect the vascular bed&#46; This shows that RT can have an antiatherogenic role&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Conclusions</span><p id="par0320" class="elsevierStylePara elsevierViewall">To summarize&#44; our results showed that a Western diet at the perinatal stage leads to dysautonomia and metabolic disorders&#44; resulting in hypertension in adulthood&#44; while an RT protocol reduced BP through positive adjustments in autonomic control mechanisms and improved BRS&#46; Furthermore&#44; RT reduced blood glucose and TC and improved the HDL&#47;LDL ratio&#46;</p><p id="par0325" class="elsevierStylePara elsevierViewall">Understanding the mechanisms by which RT improves autonomic control and biochemical profiles in experimental animals offers new possibilities for the prevention and treatment of cardiometabolic disorders caused by inappropriate diet&#46; Further studies should be conducted to elucidate the molecular and epigenetic mechanisms involved in the genesis of metabolic disorders and to understand how exercise can influence central control mechanisms&#44; going beyond endothelial mechanisms based on the release of vasoactive substances&#46;</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Conflicts of interest</span><p id="par0330" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:12 [
        0 => array:3 [
          "identificador" => "xres1270535"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Introduction and Objectives"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1175806"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres1270536"
          "titulo" => "Resumo"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Introdu&#231;&#227;o e objetivos"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclus&#227;o"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1175807"
          "titulo" => "Palavras-chave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Methods"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Animals"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Diets"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Resistance training protocol"
            ]
            3 => array:3 [
              "identificador" => "sec0030"
              "titulo" => "Experimental design"
              "secciones" => array:3 [
                0 => array:2 [
                  "identificador" => "sec0035"
                  "titulo" => "Assessment of cardiovascular function"
                ]
                1 => array:2 [
                  "identificador" => "sec0040"
                  "titulo" => "Autonomic assessment"
                ]
                2 => array:2 [
                  "identificador" => "sec0045"
                  "titulo" => "Biochemical assessment"
                ]
              ]
            ]
            4 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        6 => array:3 [
          "identificador" => "sec0055"
          "titulo" => "Results"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0060"
              "titulo" => "Changes in body weight and one-repetition maximum test results"
            ]
            1 => array:2 [
              "identificador" => "sec0065"
              "titulo" => "Hemodynamic assessment"
            ]
            2 => array:2 [
              "identificador" => "sec0070"
              "titulo" => "Cardiovascular autonomic modulation"
            ]
            3 => array:2 [
              "identificador" => "sec0075"
              "titulo" => "Biochemical variables"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0080"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0085"
          "titulo" => "Conclusions"
        ]
        9 => array:2 [
          "identificador" => "sec0090"
          "titulo" => "Conflicts of interest"
        ]
        10 => array:2 [
          "identificador" => "xack436056"
          "titulo" => "Acknowledgments"
        ]
        11 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2018-02-14"
    "fechaAceptado" => "2018-08-24"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1175806"
          "palabras" => array:3 [
            0 => "Resistance training"
            1 => "Autonomic nervous system"
            2 => "Western diet"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec1175807"
          "palabras" => array:3 [
            0 => "Treinamento de resist&#234;ncia"
            1 => "Sistema nervoso aut&#244;nomo"
            2 => "Dieta ocidental"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction and Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Consumption of a Western diet during the perinatal period is associated with development of cardiovascular disease&#46; Resistance training &#40;RT&#41; has been used to treat cardiovascular disorders&#46; The aim of this work was to assess the effect of RT on cardiometabolic disorders in rats exposed to a Western diet in the perinatal period&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Female Wistar rats were fed with control or Western diet during pregnancy and lactation&#46; The pups were divided into three groups&#58; Control &#40;C&#41;&#44; Western Diet Sedentary &#40;WDS&#41; and Western Diet&#43;RT &#40;WDRT&#41;&#46; At 60 days of age&#44; all animals started the RT protocol &#40;five times a week for four weeks&#41;&#46; At the end&#44; blood pressure was recorded for analysis of heart rate variability and baroreflex sensitivity &#40;BRS&#41;&#46; Blood samples were collected for biochemical analysis&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">RT reduced blood pressure and vascular sympathetic modulation and increased BRS&#46; There were improvements in biochemical profile&#44; with reductions in fasting blood glucose&#44; total cholesterol and low-density lipoprotein&#44; and an increase in high-density lipoprotein&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">RT led to beneficial adaptations in the cardiovascular system&#44; mediated by changes in the mechanisms of autonomic control and biochemical profile of animals exposed to a Western diet in the perinatal period&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction and Objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "pt" => array:3 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introdu&#231;&#227;o e objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">O consumo da dieta ocidental est&#225; associado ao surgimento de doen&#231;as cardiovasculares&#46; O treinamento de resist&#234;ncia &#40;TR&#41; tem sido utilizado no tratamento destas doen&#231;as&#46; O objetivo deste trabalho foi avaliar o efeito do TR sobre as altera&#231;&#245;es cardiometab&#243;licas na prole de ratas expostas a dieta ocidental no per&#237;odo perinatal&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Ratas <span class="elsevierStyleItalic">Wistar</span> receberam dieta controle ou ocidental durante a gravidez e lacta&#231;&#227;o&#46; Os filhotes foram divididos em tr&#234;s grupos&#58; Controle &#40;C&#41;&#44; dieta ocidental sedent&#225;rio &#40;OCS&#41; e dieta ocidental&#43;TR &#40;OCTR&#41;&#46; Aos 60 dias de vida&#44; os animais iniciaram o protocolo de TR realizado cinco vezes por semana durante quatro semanas&#46; Ao fim&#44; foi registrada press&#227;o arterial para an&#225;lise da variabilidade da frequ&#234;ncia card&#237;aca e sensibilidade do barorreflexo &#40;SBR&#41;&#46; Amostras de sangue foram coletadas para an&#225;lise bioqu&#237;mica&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">O TR foi capaz de reduzir a press&#227;o arterial&#44; a modula&#231;&#227;o simp&#225;tica vascular e aumentar a SBR&#46; Houve melhoria no perfil bioqu&#237;mico&#44; com redu&#231;&#227;o na glicemia de jejum&#44; colesterol total e lipoprote&#237;nas de baixa densidade&#44; al&#233;m de aumento das lipoprote&#237;nas de alta densidade&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#227;o</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">O TR promoveu adapta&#231;&#245;es ben&#233;ficas ao sistema cardiovascular&#44; mediadas por ajustes nos mecanismos de controle auton&#244;mico e perfil bioqu&#237;mico dos animais expostos &#224; dieta ocidental no per&#237;odo perinatal&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introdu&#231;&#227;o e objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclus&#227;o"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0030">Please cite this article as&#58; Santana MNS&#44; De Melo VU&#44; Macedo FN&#44; et al&#46; Treinamento resistido melhora controle auton&#244;mico cardiovascular e perfil bioqu&#237;mico de ratos expostos a dieta ocidental no per&#237;odo perinatal&#46; Rev Port Cardiol&#46; 2019&#59;38&#58;337&#8211;345&#46;</p>"
      ]
    ]
    "nomenclatura" => array:1 [
      0 => array:3 [
        "identificador" => "nom0005"
        "titulo" => "<span class="elsevierStyleSectionTitle" id="sect0065">List of abbreviations</span>"
        "listaDefinicion" => array:1 [
          0 => array:1 [
            "definicion" => array:24 [
              0 => array:2 [
                "termino" => "1RM"
                "descripcion" => "<p id="par0005" class="elsevierStylePara elsevierViewall">one-repetition maximum test</p>"
              ]
              1 => array:2 [
                "termino" => "ACSM"
                "descripcion" => "<p id="par0010" class="elsevierStylePara elsevierViewall">American College of Sports Medicine</p>"
              ]
              2 => array:2 [
                "termino" => "BP"
                "descripcion" => "<p id="par0015" class="elsevierStylePara elsevierViewall">blood pressure</p>"
              ]
              3 => array:2 [
                "termino" => "BRS"
                "descripcion" => "<p id="par0020" class="elsevierStylePara elsevierViewall">baroreflex sensitivity</p>"
              ]
              4 => array:2 [
                "termino" => "DBP"
                "descripcion" => "<p id="par0025" class="elsevierStylePara elsevierViewall">diastolic blood pressure</p>"
              ]
              5 => array:2 [
                "termino" => "GLUT4"
                "descripcion" => "<p id="par0030" class="elsevierStylePara elsevierViewall">glucose transporter 4</p>"
              ]
              6 => array:2 [
                "termino" => "HBS"
                "descripcion" => "<p id="par0035" class="elsevierStylePara elsevierViewall">Household Budget Survey</p>"
              ]
              7 => array:2 [
                "termino" => "HDL"
                "descripcion" => "<p id="par0040" class="elsevierStylePara elsevierViewall">high-density lipoprotein</p>"
              ]
              8 => array:2 [
                "termino" => "HF"
                "descripcion" => "<p id="par0045" class="elsevierStylePara elsevierViewall">high frequency component</p>"
              ]
              9 => array:2 [
                "termino" => "HR"
                "descripcion" => "<p id="par0050" class="elsevierStylePara elsevierViewall">heart rate</p>"
              ]
              10 => array:2 [
                "termino" => "LDL"
                "descripcion" => "<p id="par0055" class="elsevierStylePara elsevierViewall">low-density lipoprotein</p>"
              ]
              11 => array:2 [
                "termino" => "LF"
                "descripcion" => "<p id="par0060" class="elsevierStylePara elsevierViewall">low frequency component</p>"
              ]
              12 => array:2 [
                "termino" => "MAP"
                "descripcion" => "<p id="par0065" class="elsevierStylePara elsevierViewall">mean arterial pressure</p>"
              ]
              13 => array:2 [
                "termino" => "NST"
                "descripcion" => "<p id="par0070" class="elsevierStylePara elsevierViewall">nucleus of the solitary tract</p>"
              ]
              14 => array:2 [
                "termino" => "PI"
                "descripcion" => "<p id="par0075" class="elsevierStylePara elsevierViewall">pulse interval</p>"
              ]
              15 => array:2 [
                "termino" => "PVN"
                "descripcion" => "<p id="par0080" class="elsevierStylePara elsevierViewall">paraventricular nucleus of the hypothalamus</p>"
              ]
              16 => array:2 [
                "termino" => "RT"
                "descripcion" => "<p id="par0085" class="elsevierStylePara elsevierViewall">resistance training</p>"
              ]
              17 => array:2 [
                "termino" => "SBP"
                "descripcion" => "<p id="par0090" class="elsevierStylePara elsevierViewall">systolic blood pressure</p>"
              ]
              18 => array:2 [
                "termino" => "TC"
                "descripcion" => "<p id="par0095" class="elsevierStylePara elsevierViewall">total cholesterol</p>"
              ]
              19 => array:2 [
                "termino" => "TG"
                "descripcion" => "<p id="par0100" class="elsevierStylePara elsevierViewall">triglycerides</p>"
              ]
              20 => array:2 [
                "termino" => "VLDL"
                "descripcion" => "<p id="par0105" class="elsevierStylePara elsevierViewall">very low-density lipoprotein</p>"
              ]
              21 => array:2 [
                "termino" => "VLF"
                "descripcion" => "<p id="par0110" class="elsevierStylePara elsevierViewall">very low frequency component</p>"
              ]
              22 => array:2 [
                "termino" => "WDRT"
                "descripcion" => "<p id="par0115" class="elsevierStylePara elsevierViewall">Western diet trained</p>"
              ]
              23 => array:2 [
                "termino" => "WDS"
                "descripcion" => "<p id="par0120" class="elsevierStylePara elsevierViewall">Western diet sedentary</p>"
              ]
            ]
          ]
        ]
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2625
            "Ancho" => 2463
            "Tamanyo" => 171525
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Cardiovascular autonomic modulation and spontaneous baroreflex sensitivity after four weeks of resistance training&#46; BRS&#58; baroreflex sensitivity&#59; C&#58; control group&#59; HF&#58; high frequency&#59; LF&#58; low frequency&#59; LFSBP&#58; low frequency component of systolic blood pressure&#59; NU&#58; normalized units&#59; WDRT&#58; Western diet trained group&#59; WDS&#58; Western diet sedentary group&#46; <span class="elsevierStyleSup">a</span>p&#60;0&#46;05 for WDRT vs&#46; WDS&#59; p&#60;0&#46;05 for WDRT vs&#46; C&#59; <span class="elsevierStyleSup">b</span>p&#60;0&#46;05 for WDS vs&#46; C&#59; <span class="elsevierStyleSup">c</span>p&#60;0&#46;05 for WDRT vs&#46; C&#46; One-way analysis of variance was used followed by the Bonferroni post hoc test&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1237
            "Ancho" => 3167
            "Tamanyo" => 174812
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Experimental design&#58; mating&#44; beginning of experimental diets&#44; resistance training &#40;RT&#41; protocol and recording of cardiovascular variables&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">1RM&#58; one-repetition maximum&#59; C&#58; control group&#59; WDRT&#58; Western diet trained group&#59; WDS&#58; Western diet sedentary group&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Period&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C &#40;n&#61;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">WDS &#40;n&#61;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">WDRT &#40;n&#61;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="middle">Body mass&#44; g</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Initial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">266&#46;3&#177;2&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">280&#46;3&#177;6&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">277&#46;3&#177;4&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Final&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">300&#177;3&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">308&#46;4&#177;5&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">309&#46;1&#177;3&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="middle">1RM&#44; g</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Initial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1340&#177;58&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1420&#177;81&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1480&#177;55&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Final&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1560&#177;54&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1710&#177;83&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1770&#177;57&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="middle">1RM&#47;body mass</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Initial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;98&#177;0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;0&#177;0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;3&#177;0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Final&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;11&#177;0&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;59&#177;0&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;81&#177;0&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2173410.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Changes in weight&#44; absolute one-repetition maximum and one-repetition maximum&#47;body mass of animals after the resistance training protocol&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">One-way analysis of variance was used followed by the Bonferroni post hoc test&#46;</p><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">C&#58; control group&#59; DBP&#58; diastolic blood pressure&#59; HR&#58; heart rate&#59; MAP&#58; mean arterial pressure&#59; SBP&#58; systolic blood pressure&#59; WDRT&#58; Western diet trained group&#59; WDS&#58; Western diet sedentary group&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C &#40;n&#61;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">WDS &#40;n&#61;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">WDRT &#40;n&#61;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HR&#44; bpm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">383&#46;7&#177;12&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">367&#46;2&#177;13&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">354&#46;0&#177;7&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DBP&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82&#46;8&#177;2&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">99&#177;3&#46;0<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89&#46;1&#177;2&#46;8<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MAP&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">103&#46;2&#177;3&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121&#46;1&#177;2&#46;6<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">108&#46;2&#177;3&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SBP&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">134&#46;2&#177;5&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">151&#46;5&#177;3&#46;4<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">135&#46;2&#177;3&#46;1<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2173409.png"
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">p&#60;0&#46;05 for WDRT vs&#46; WDS&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">p&#60;0&#46;05 for WDS vs&#46; C&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Hemodynamic variables recorded 24 hours after the resistance training protocol&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">One-way analysis of variance was used followed by the Bonferroni post hoc test&#46;</p><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">C&#58; control group&#59; HDL&#58; high-density lipoprotein&#59; LDL&#58; low-density lipoprotein&#59; TC&#58; total cholesterol&#59; TG&#58; triglycerides&#59; VLDL&#58; very low-density lipoprotein&#59; WDRT&#58; Western diet trained group&#59; WDS&#58; Western diet sedentary group&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C &#40;n&#61;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">WDS &#40;n&#61;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">WDRT &#40;n&#61;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&#46;8&#177;1&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85&#46;6&#177;3&#46;4<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&#46;0&#177;3&#46;8<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glucose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">126&#46;2&#177;3&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">153&#46;8&#177;6&#46;3<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">116&#46;2&#177;4&#46;6<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HDL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#46;5&#177;0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&#46;8&#177;2&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#46;2&#177;3&#46;5<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LDL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;1&#177;0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#46;0&#177;3&#46;2<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#46;2&#177;2&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#46;4&#177;2&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#46;0&#177;2&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;2&#177;4&#46;8<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VLDL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;1&#177;0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#46;0&#177;0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;4&#177;0&#46;8<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2173408.png"
              ]
            ]
          ]
          "notaPie" => array:3 [
            0 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">p&#60;0&#46;05 for WDRT vs&#46; WDS&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">p&#60;0&#46;05 for WDRT vs&#46; C&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0025"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0025">p&#60;0&#46;05 for WDS vs&#46; C&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Biochemical variables assessed in blood samples collected 24 hours after the resistance training protocol&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:38 [
            0 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Where&#39;s the fat&#63; Trends in U&#46;S&#46; Diets 1965&#8211;1996"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46;M&#46; Popkin"
                            1 => "A&#46;M&#46; Siega-Riz"
                            2 => "P&#46;S&#46; Haines"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1006/pmed.2000.0807"
                      "Revista" => array:6 [
                        "tituloSerie" => "Prev Med"
                        "fecha" => "2001"
                        "volumen" => "32"
                        "paginaInicial" => "245"
                        "paginaFinal" => "254"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11277682"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nutritional transition in Brazil&#58; geographic and temporal trends"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Batista Filho"
                            1 => "A&#46; Rissin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/s0102-311x2003000700019"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cad Sa&#250;de P&#250;blica"
                        "fecha" => "2003"
                        "volumen" => "19"
                        "paginaInicial" => "S181"
                        "paginaFinal" => "S191"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12886448"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;C&#46; Ochoa"
                            1 => "M&#46;J&#46; Moreno-Aliaga"
                            2 => "M&#46;A&#46; Mart&#237;nez-Gonz&#225;lez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/17477160600650386"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Pediatr Obes"
                        "fecha" => "2006"
                        "volumen" => "1"
                        "paginaInicial" => "83"
                        "paginaFinal" => "88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17907319"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malnutrition&#58; long-term consequences and nutritional recovery effects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;L&#46; Sawaya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Estud Av"
                        "fecha" => "2006"
                        "volumen" => "20"
                        "paginaInicial" => "147"
                        "paginaFinal" => "158"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Maternal prepregnancy body mass index and their children&#39;s blood pressure and resting cardiac autonomic balance at age 5 to 6 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;G&#46;J&#46; Gademan"
                            1 => "M&#46; van Eijsden"
                            2 => "T&#46;J&#46; Roseboom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/HYPERTENSIONAHA.113.01511"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2013"
                        "volumen" => "62"
                        "paginaInicial" => "641"
                        "paginaFinal" => "647"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23876476"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The origins of the developmental origins theory"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;J&#46;P&#46; Barker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2796.2007.01809.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Intern Med"
                        "fecha" => "2007"
                        "volumen" => "261"
                        "paginaInicial" => "412"
                        "paginaFinal" => "417"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17444880"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Developmental and epigenetic pathways to obesity&#58; an evolutionary-developmental perspective"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;D&#46; Gluckman"
                            1 => "M&#46;A&#46; Hanson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Obes"
                        "fecha" => "2008"
                        "volumen" => "32"
                        "paginaInicial" => "S62"
                        "paginaFinal" => "S71"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Perinatal exposure to high-fat diet programs energy balance&#44; metabolism and behavior in adulthood"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46;L&#46; Sullivan"
                            1 => "M&#46;S&#46; Smith"
                            2 => "K&#46;L&#46; Grove"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000322038"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neuroendocrinology"
                        "fecha" => "2011"
                        "volumen" => "93"
                        "paginaInicial" => "1"
                        "paginaFinal" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21079387"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Western diet in the perinatal period promotes dysautonomia in the offspring of adult rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Vidal-Santos"
                            1 => "F&#46;N&#46; Macedo"
                            2 => "M&#46;N&#46;S&#46; Santana"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1017/S2040174416000623"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dev Orig Health Dis"
                        "fecha" => "2017"
                        "volumen" => "8"
                        "paginaInicial" => "216"
                        "paginaFinal" => "225"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27931267"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased nitric oxide bioavailability and decreased sympathetic modulation are involved in vascular adjustments induced by low-intensity resistance training"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "F&#46;N&#46; Macedo"
                            1 => "T&#46;R&#46;R&#46; Mesquita"
                            2 => "V&#46;U&#46; Melo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fphys.2016.00265"
                      "Revista" => array:4 [
                        "tituloSerie" => "Front Physiol"
                        "fecha" => "2016"
                        "volumen" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27920726"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Resistance exercise restores endothelial function and reduces blood pressure in type 1 diabetic rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;M&#46; Mota"
                            1 => "T&#46;L&#46;T&#46;B&#46; da Silva"
                            2 => "M&#46;T&#46; Fontes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5935/abc.20140087"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arq Bras Cardiol"
                        "fecha" => "2014"
                        "volumen" => "103"
                        "paginaInicial" => "25"
                        "paginaFinal" => "32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25120082"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "AIN-93 purified diets for laboratory rodents&#58; final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;G&#46; Reeves"
                            1 => "F&#46;H&#46; Nielsen"
                            2 => "G&#46;C&#46; Fahey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/jn/123.11.1939"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Nutr"
                        "fecha" => "1993"
                        "volumen" => "123"
                        "paginaInicial" => "1939"
                        "paginaFinal" => "1951"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8229312"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A weight-lifting exercise model for inducing hypertrophy in the hindlimb muscles of rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; Tamaki"
                            1 => "S&#46; Uchiyama"
                            2 => "S&#46; Nakano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Sci Sports Exerc"
                        "fecha" => "1992"
                        "volumen" => "24"
                        "paginaInicial" => "881"
                        "paginaFinal" => "886"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1406173"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "American College of Sports Medicine position stand&#46; Progression models in resistance training for healthy adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "American College of Sports Medicine"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1249/MSS.0b013e3181915670"
                      "Revista" => array:7 [
                        "tituloSerie" => "Med Sci Sports Exerc"
                        "fecha" => "2009"
                        "volumen" => "41"
                        "paginaInicial" => "687"
                        "paginaFinal" => "708"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19204579"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0738399117304081"
                          "estado" => "S300"
                          "issn" => "07383991"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ovarian hormone deprivation reduces oxytocin expression in paraventricular nucleus preautonomic neurons and correlates with baroreflex impairment in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "V&#46;U&#46; De Melo"
                            1 => "R&#46;R&#46;M&#46; Saldanha"
                            2 => "C&#46;R&#46; Dos Santos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fphys.2016.00557"
                      "Revista" => array:4 [
                        "tituloSerie" => "Front Physiol"
                        "fecha" => "2016"
                        "volumen" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27920726"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estimation of the concentration of low-density lipoprotein cholesterol in plasma&#44; without use of the preparative ultracentrifuge"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46;T&#46; Friedewald"
                            1 => "R&#46;I&#46; Levy"
                            2 => "D&#46;S&#46; Fredrickson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chem"
                        "fecha" => "1972"
                        "volumen" => "18"
                        "paginaInicial" => "499"
                        "paginaFinal" => "502"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4337382"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of 14 weeks of resistance training on lipid profile and body fat percentage in premenopausal women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46; Prabhakaran"
                            1 => "E&#46;A&#46; Dowling"
                            2 => "J&#46;D&#46; Branch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bjsm.33.3.190"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Sports Med"
                        "fecha" => "1999"
                        "volumen" => "33"
                        "paginaInicial" => "190"
                        "paginaFinal" => "195"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10378072"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efeito de 12 semanas de treinamento com pesos sobre a for&#231;a muscular&#44; composi&#231;&#227;o corporal e triglic&#233;rides em homens sedent&#225;rios"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;D&#46; Polito"
                            1 => "E&#46;S&#46; Cyrino"
                            2 => "A&#46;M&#46; Gerage"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Bras Med Esporte"
                        "fecha" => "2010"
                        "volumen" => "16"
                        "paginaInicial" => "29"
                        "paginaFinal" => "32"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of changing levels of physical activity on blood-pressure and haemodynamics in essential hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46; Nelson"
                            1 => "G&#46;L&#46; Jennings"
                            2 => "M&#46;D&#46; Esler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet Lond Engl"
                        "fecha" => "1986"
                        "volumen" => "2"
                        "paginaInicial" => "473"
                        "paginaFinal" => "476"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exercise training normalizes wall-to-lumen ratio of the gracilis muscle arterioles and reduces pressure in spontaneously hypertensive rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;L&#46; Amaral"
                            1 => "T&#46;M&#46;T&#46; Zorn"
                            2 => "L&#46;C&#46; Michelini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00004872-200018110-00006"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2000"
                        "volumen" => "18"
                        "paginaInicial" => "1563"
                        "paginaFinal" => "1572"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11081768"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1525505015001201"
                          "estado" => "S300"
                          "issn" => "15255050"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;S&#46; V&#233;ras-Silva"
                            1 => "K&#46;C&#46; Mattos"
                            2 => "N&#46;S&#46; Gava"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Physiol &#8211; Heart Circ Physiol"
                        "fecha" => "1997"
                        "volumen" => "273"
                        "paginaInicial" => "H2627"
                        "paginaFinal" => "H2631"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exercise and endothelial function&#58; role of endothelium-derived nitric oxide and oxidative stress in healthy subjects and hypertensive patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Y&#46; Higashi"
                            1 => "M&#46; Yoshizumi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.pharmthera.2004.02.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacol Ther"
                        "fecha" => "2004"
                        "volumen" => "102"
                        "paginaInicial" => "87"
                        "paginaFinal" => "96"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15056500"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exercise training-induced remodeling of paraventricular nucleus &#40;nor&#41;adrenergic innervation in normotensive and hypertensive rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46;T&#46; Higa-Taniguchi"
                            1 => "F&#46;C&#46;P&#46; Silva"
                            2 => "H&#46;M&#46;V&#46; Silva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/ajpregu.00613.2006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol &#8211; Regul Integr Comp Physiol"
                        "fecha" => "2007"
                        "volumen" => "292"
                        "paginaInicial" => "R1717"
                        "paginaFinal" => "R1727"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17218443"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The NTS and integration of cardiovascular control during exercise in normotensive and hypertensive individuals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46;C&#46; Michelini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11906-007-0039-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Hypertens Rep"
                        "fecha" => "2007"
                        "volumen" => "9"
                        "paginaInicial" => "214"
                        "paginaFinal" => "221"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17519128"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exercise training differentially affects intrinsic excitability of autonomic and neuroendocrine neurons in the hypothalamic paraventricular nucleus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Jackson"
                            1 => "H&#46;M&#46;V&#46; Silva"
                            2 => "W&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/jn.00277.2005"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurophysiol"
                        "fecha" => "2005"
                        "volumen" => "94"
                        "paginaInicial" => "3211"
                        "paginaFinal" => "3220"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16049146"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypertension and exercise training differentially affect oxytocin and oxytocin receptor expression in the brain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;S&#46; Martins"
                            1 => "A&#46; Crescenzi"
                            2 => "J&#46;E&#46; Stern"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.HYP.0000175812.03322.59"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2005"
                        "volumen" => "46"
                        "paginaInicial" => "1004"
                        "paginaFinal" => "1009"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16157794"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Baroreflex control of heart rate by oxytocin in the solitary-vagal complex"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46;T&#46; Higa"
                            1 => "E&#46; Mori"
                            2 => "F&#46;F&#46; Viana"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/ajpregu.00806.2000"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol &#8211; Regul Integr Comp Physiol"
                        "fecha" => "2002"
                        "volumen" => "282"
                        "paginaInicial" => "R537"
                        "paginaFinal" => "R545"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11792664"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity-associated hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Rahmouni"
                            1 => "M&#46;L&#46;G&#46; Correia"
                            2 => "W&#46;G&#46; Haynes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.HYP.0000151325.83008.b4"
                      "Revista" => array:7 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2005"
                        "volumen" => "45"
                        "paginaInicial" => "9"
                        "paginaFinal" => "14"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15583075"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1059131116303247"
                          "estado" => "S300"
                          "issn" => "10591311"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Arterial baroreflex modulation of sympathetic activity and arterial wall properties"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Parati"
                            1 => "G&#46; Bilo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/HYPERTENSIONAHA.111.182766"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2012"
                        "volumen" => "59"
                        "paginaInicial" => "5"
                        "paginaFinal" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22106402"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute and chronic effects of resistive exercise on blood pressure in hypertensive elderly women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;R&#46; Mota"
                            1 => "R&#46;J&#46; de Oliveira"
                            2 => "M&#46;T&#46; Dutra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1519/JSC.0b013e31828f2766"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Strength Cond Res"
                        "fecha" => "2013"
                        "volumen" => "27"
                        "paginaInicial" => "3475"
                        "paginaFinal" => "3480"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23478476"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1525505015004837"
                          "estado" => "S300"
                          "issn" => "15255050"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Resistance exercise acutely enhances mesenteric artery insulin-induced relaxation in healthy rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;T&#46; Fontes"
                            1 => "T&#46;L&#46;B&#46;T&#46; Silva"
                            2 => "M&#46;M&#46; Mota"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.lfs.2013.11.017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Life Sci"
                        "fecha" => "2014"
                        "volumen" => "94"
                        "paginaInicial" => "24"
                        "paginaFinal" => "29"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24316143"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early exposure of dams to a westernized diet has long-term consequences on food intake and physiometabolic homeostasis of the rat offspring"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46;C&#46;F&#46; Cavalcante"
                            1 => "A&#46;A&#46;M&#46; da Silva"
                            2 => "M&#46;C&#46;A&#46; Lira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/09637486.2014.950208"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Food Sci Nutr"
                        "fecha" => "2014"
                        "volumen" => "65"
                        "paginaInicial" => "989"
                        "paginaFinal" => "993"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25198159"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "GLUT4 protein expression in obese and lean 12-month-old rats&#58; insights from different types of data analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;M&#46; Seraphim"
                            1 => "M&#46;T&#46; Nunes"
                            2 => "U&#46;F&#46; Machado"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/s0100-879x2001001000018"
                      "Revista" => array:7 [
                        "tituloSerie" => "Braz J Med Biol Res"
                        "fecha" => "2001"
                        "volumen" => "34"
                        "paginaInicial" => "1353"
                        "paginaFinal" => "1362"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11593313"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0733861909000474"
                          "estado" => "S300"
                          "issn" => "07338619"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Strength training increases insulin-mediated glucose uptake&#44; GLUT4 content&#44; and insulin signaling in skeletal muscle in patients with type 2 diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;K&#46; Holten"
                            1 => "M&#46; Zacho"
                            2 => "M&#46; Gaster"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2337/diabetes.53.2.294"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes"
                        "fecha" => "2004"
                        "volumen" => "53"
                        "paginaInicial" => "294"
                        "paginaFinal" => "305"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14747278"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46; Castaneda"
                            1 => "J&#46;E&#46; Layne"
                            2 => "L&#46; Munoz-Orians"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2337/diacare.25.12.2335"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2002"
                        "volumen" => "25"
                        "paginaInicial" => "2335"
                        "paginaFinal" => "2341"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12453982"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exercise training and blood lipids in hyperlipidemic and normolipidemic adults&#58; a meta-analysis of randomized&#44; controlled trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;A&#46; Halbert"
                            1 => "C&#46;A&#46; Silagy"
                            2 => "P&#46; Finucane"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.ejcn.1600784"
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur J Clin Nutr"
                        "fecha" => "1999"
                        "volumen" => "53"
                        "paginaInicial" => "514"
                        "paginaFinal" => "522"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10452405"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1059131115002149"
                          "estado" => "S300"
                          "issn" => "10591311"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of strength and endurance training on insulin sensitivity and fat distribution in human immunodeficiency virus-infected patients with lipodystrophy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46; Lindegaard"
                            1 => "T&#46; Hansen"
                            2 => "T&#46; Hvid"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2007-2733"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2008"
                        "volumen" => "93"
                        "paginaInicial" => "3860"
                        "paginaFinal" => "3869"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18628529"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Conditional risk factors for atherosclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "I&#46;J&#46; Kullo"
                            1 => "C&#46;M&#46; Ballantyne"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4065/80.2.219"
                      "Revista" => array:7 [
                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "2005"
                        "volumen" => "80"
                        "paginaInicial" => "219"
                        "paginaFinal" => "230"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15704777"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1059131116303223"
                          "estado" => "S300"
                          "issn" => "10591311"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack436056"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0335" class="elsevierStylePara elsevierViewall">We thank the <span class="elsevierStyleGrantSponsor" id="gs1">Coordination for the Improvement of Higher Education Personnel &#40;CAPES&#41;</span> and the <span class="elsevierStyleGrantSponsor" id="gs2">Foundation for Scientific and Technological Research of Sergipe &#40;FAPITEC&#41;</span>&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21742049/0000003800000005/v2_201911300820/S2174204919301497/v2_201911300820/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9917"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21742049/0000003800000005/v2_201911300820/S2174204919301497/v2_201911300820/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204919301497?idApp=UINPBA00004E"
]

Article information

ISSN: 21742049
Original language: English

DOI:10.1016/j.repce.2018.08.008

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	5	6	11
2024 October	31	35	66
2024 September	46	32	78
2024 August	35	28	63
2024 July	27	26	53
2024 June	23	21	44
2024 May	32	23	55
2024 April	29	27	56
2024 March	34	24	58
2024 February	24	21	45
2024 January	32	40	72
2023 December	35	21	56
2023 November	55	39	94
2023 October	29	15	44
2023 September	45	24	69
2023 August	33	16	49
2023 July	25	12	37
2023 June	31	14	45
2023 May	41	32	73
2023 April	28	12	40
2023 March	69	26	95
2023 February	55	17	72
2023 January	16	15	31
2022 December	49	39	88
2022 November	52	41	93
2022 October	42	39	81
2022 September	30	37	67
2022 August	39	24	63
2022 July	27	39	66
2022 June	31	29	60
2022 May	28	37	65
2022 April	32	37	69
2022 March	32	51	83
2022 February	31	44	75
2022 January	30	31	61
2021 December	25	25	50
2021 November	23	25	48
2021 October	32	34	66
2021 September	24	30	54
2021 August	27	32	59
2021 July	19	28	47
2021 June	25	22	47
2021 May	39	34	73
2021 April	34	35	69
2021 March	38	13	51
2021 February	41	16	57
2021 January	24	16	40
2020 December	24	22	46
2020 November	36	17	53
2020 October	18	12	30
2020 September	28	16	44
2020 August	21	13	34
2020 July	23	14	37
2020 June	26	18	44
2020 May	27	11	38
2020 April	19	19	38
2020 March	26	21	47
2020 February	30	35	65
2020 January	15	8	23
2019 December	33	17	50
2019 November	8	9	17
2019 October	27	9	36
2019 September	25	16	41
2019 August	14	9	23
2019 July	26	27	53
2019 June	1	2	3

Show all

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter