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"referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Adelaide" "apellidos" => "Dias" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 7 => array:3 [ "nombre" => "Vasco Gama" "apellidos" => "Ribeiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Cardiology, Vila Nova de Gaia/Espinho Hospital Center, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine of the University of Porto, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Anesthesiology, Vila Nova de Gaia/Espinho Hospital Center, Portugal" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Choque cardiogénico induzido pela miocardiopatia de Takotsubo - Uma nova opção terapêutica" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 615 "Ancho" => 1501 "Tamanyo" => 86999 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Selective coronary angiography. Left (left) and right (right) coronary arteries, showing absence of coronary artery disease.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Takotsubo cardiomyopathy (TC) (as it was first named in 1990 by Sato et al. in Japan), also known as stress-induced cardiomyopathy or broken heart syndrome, is a transient left ventricular apical ballooning syndrome characterized by left ventricular dysfunction, that usually occurs after a sudden emotional or physical stress. The Japanese word ‘takotsubo’ means ‘octopus pot’; pots used to catch octopuses have a round bottom and a narrow neck, thus trapping the creatures until they are pulled out by the fisherman.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">The presentation of TC is similar to that of an acute coronary syndrome (ACS), patients presenting with cardiac chest pain, raised levels of cardiac enzymes and acute changes on the electrocardiogram (ECG), although with absence of obstructive coronary artery disease.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a> Series suggest that TC affects approximately 1–2% of patients initially diagnosed with an ACS.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Different pathophysiological mechanisms have been proposed to explain this syndrome, such as occult atherosclerotic disease, multivessel spasm and microvascular dysfunction. The most widely accepted hypothesis nowadays is that of catecholamine excess causing calcium overload in cardiac myocytes, leading to disruption of contraction and ventricular function.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The long-term prognosis is excellent, with only 1–2% of reported patients dying during hospitalization. Serious complications including cardiogenic shock and arrhythmias may, however, occur acutely. Supportive treatment is the mainstay of therapy.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In cardiogenic shock, mechanical circulatory support can be lifesaving. Intra-aortic balloon pump (IABP) and extracorporeal life support (ECLS) are alternatives.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">We report the successful use of ECLS to treat a patient with TC presenting with cardiogenic shock.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0035" class="elsevierStylePara elsevierViewall">A 72-year-old female patient presented to the emergency department with chest pain and dyspnea of one hour's duration. Her medical history consisted of hypertension, dyslipidemia and paroxysmal atrial fibrillation. She was under losartan 100 mg plus hydrochlorothiazide 12.5 mg, pitavastatin 4 mg and propafenone 300 mg.</p><p id="par0040" class="elsevierStylePara elsevierViewall">At admission her blood pressure was 170/130 mmHg, heart rate 100 beats/min and oxygen saturation 70% on room air. On physical examination the patient had diminished cardiac sounds and bilateral crackles up to the lung apices. Furosemide, intravenous nitrates and oxygen were started. An ECG demonstrated ST-segment elevation in the precordial leads V2-V4, and cardiac biomarkers were mildly elevated. A transthoracic echocardiographic examination showed mechanical alterations in the myocardium supplied by the left anterior descending artery.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Despite therapy the patient progressed to cardiogenic shock; invasive ventilation and inotropic support were initiated, and she was transferred to our hospital for primary percutaneous coronary intervention.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Angiography revealed absence of obstructive coronary disease or acute plaque rupture (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>). Ventriculography showed apical and midventricular dysfunction with hyperkinesis of the basal myocardial segments and severely depressed ejection fraction (<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>). A second detailed transthoracic echocardiographic examination confirmed apical akinesis, basal hyperkinesis and severe systolic left ventricular (LV) dysfunction; apical ballooning syndrome was confirmed.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">The patient was admitted to the coronary intensive care unit under midazolam, noradrenaline (60 μg/min) and dobutamine (1.8 μg/kg/min), and some minutes later developed pulseless monomorphic ventricular tachycardia, rapidly reverted to sinus rhythm. Despite aggressive therapy with fluids and increasing doses of noradrenaline and dobutamine she remained hemodynamically unstable. Since TC is a reversible condition, usually in a short period, therapy with ECLS was considered as a lifesaving alternative.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Venous-arterial (VA)-ECLS was performed with 19 French (F) venous femoral cannulation and 17F arterial femoral cannulation. Anticoagulation with unfractionated heparin was initiated, for a target activated clotting time of 150–200 s. Bypass flow was fixed initially at 2.8 l/min. The vital parameters stabilized rapidly after ECLS and inotropic support was reduced.</p><p id="par0065" class="elsevierStylePara elsevierViewall">At the end of the second day pulsatility on the arterial pressure waveform was evident and another transthoracic echocardiogram was performed. This echocardiogram showed no regional wall motion abnormalities, and ejection fraction was nearly normal. ECLS flow was progressively reduced, and on day 3 the system was explanted.</p><p id="par0070" class="elsevierStylePara elsevierViewall">During ECLS four units of red blood cells and one unit of platelets were transfused, to maintain hemoglobin concentration above 10 g/dl and a platelet count >70<span class="elsevierStyleHsp" style=""></span>000 U/l.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Ventilator-associated pneumonia was diagnosed one day after ECLS withdrawal and the patient was started on antibiotics. Three days after ECLS the patient was in spontaneous ventilation and was transferred to her primary hospital.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0080" class="elsevierStylePara elsevierViewall">TC, also known as stress-induced cardiomyopathy, is an increasingly recognized clinical syndrome characterized by transient left ventricular dysfunction and wall motion abnormalities involving the apical and mid portions of the left ventricle, although atypical forms have also been described.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,10</span></a> It usually occurs in postmenopausal women after severe emotional or physical stress, although in some cases the trigger is unknown.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5,11</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Clinical presentation can mimic an acute coronary syndrome, with patients complaining of chest pain and dyspnea and with ST-segment elevation on the ECG and elevated cardiac enzymes. Angiography is crucial to the differential diagnosis, since in TC there are no significant obstructive coronary lesions.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–4</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">The diagnostic criteria proposed by the Mayo Clinic are: transient hypokinesis, akinesis, or dyskinesis in the left ventricular mid segments with or without apical involvement; regional wall motion abnormalities that extend beyond a single epicardial vascular distribution; frequently, but not always, a stressful trigger; the absence of obstructive coronary disease or angiographic evidence of acute plaque rupture; new ECG abnormalities (ST-segment elevation and/or T-wave inversion) or modest elevation in cardiac troponin; and the absence of pheochromocytoma and myocarditis.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">The pathophysiology of TC is not well understood. Given that the onset of this syndrome is usually preceded by emotional or physical stress, direct catecholamine-mediated myocyte injury has been advocated as the most probable mechanism.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Patients with TC generally have a good prognosis, with rapid improvement in LV systolic function within a few days or weeks.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> A variety of complications may occur in the acute phase of the disease, such as acute heart failure with pulmonary edema or cardiogenic shock, development of intraventricular pressure gradients, acute functional mitral regurgitation, right ventricular dysfunction, intraventricular thrombi resulting in stroke or arterial embolism, atrial fibrillation or malignant ventricular arrhythmias.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> In patients who develop such complications, treatment represents a real challenge. When the initial presentation of TC is cardiogenic shock, vasoactive drugs to maintain blood pressure and improve tissue perfusion seem a reasonable option. However, given the presumptive pathophysiology of this syndrome, vasopressors may cause more harm than benefit.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,8,11</span></a> In the patient presented, vasoactive drugs were started, given that ACS was the initial presumptive diagnosis. Worsening hemodynamics might have been partly due to this treatment. Mechanical support in hemodynamically unstable TC patients is the most logical alternative. Just after establishing TC as the correct diagnosis, the patient collapsed with low oxygen saturation, and so it was decided to initiate ECLS therapy as a bridge to recovery.</p><p id="par0105" class="elsevierStylePara elsevierViewall">The first successful use of ECLS was reported in 1972, and since this report an increasing number of individuals have been saved thanks to this temporary form of life support.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">ECLS uses a modified heart-lung mechanical interface generally consisting of a centrifugal pump, a heat exchanger, and a membrane oxygenator. In VA-ECLS deoxygenated blood is withdrawn through a drainage cannula (from the venous system) by an external pump, passing through the oxygenator and returning to the patient through a reinfusion cannula inserted in an artery. Unlike veno-venous ECLS, VA-ECLS offers both respiratory and circulatory support.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Bleeding remains the main complication in ECLS patients. Other less common complications include blood clots, pump or oxygenator failure, neurologic and musculoskeletal complications, limb ischemia, infection, renal failure and problems during cannulation.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> In a recent study Loforte et al. identified blood lactate level, creatine kinase-MB isoenzyme relative index at 72 h after ECLS initiation, and number of packed red blood cells transfused while on ECLS as significant predictors of mortality.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Further studies are necessary to improve our knowledge of which patients will gain most from ECLS support.</p><p id="par0120" class="elsevierStylePara elsevierViewall">In our case ECLS minimized cardiac work and improved tissue perfusion, enabling a significant reduction in doses of vasoactive drugs. Three days after implantation the patient was successfully weaned from support and cardiac function had completely recovered. There are some cases in the literature of TC successfully bridged to recovery with ECLS,<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18–24</span></a> but this is, to our knowledge, the first reported case of TC with refractory cardiogenic shock treated with ECLS in Portugal.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Ethical disclosures</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Protection of human and animal subjects</span><p id="par0125" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Confidentiality of data</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Right to privacy and informed consent</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflicts of interest</span><p id="par0140" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres816413" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec813649" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres816412" "titulo" => "Resumo" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec813650" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:3 [ "identificador" => "sec0020" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0030" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0035" "titulo" => "Right to privacy and informed consent" ] ] ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflicts of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-01-26" "fechaAceptado" => "2015-03-21" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec813649" "palabras" => array:3 [ 0 => "Takotsubo cardiomyopathy" 1 => "Cardiogenic shock" 2 => "Extracorporeal life support" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec813650" "palabras" => array:3 [ 0 => "Miocardiopatia de Takotsubo" 1 => "Choque cardiogénico" 2 => "Suporte de vida extracorporal" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Takotsubo cardiomyopathy (TC) is characterized by the sudden onset of reversible left ventricular dysfunction, with a presentation similar to that of an acute coronary syndrome. Although cardiogenic shock is a rare occurrence in TC, if it does occur it may require the use of a left ventricular assist device.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We report the use of extracorporeal life support (ECLS) in a patient with TC and refractory cardiogenic shock. With ECLS it was possible to reduce inotropic support, and a normal left ventricular ejection fraction was documented by echocardiography on day 2.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">This is, to our knowledge, the first reported case of TC with refractory cardiogenic shock treated with ECLS in Portugal.</p></span>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A miocardiopatia de Takotsubo (MT) é caracterizada por uma disfunção ventricular esquerda súbita, tendo uma apresentação semelhante à de uma síndrome coronária aguda. Apesar do choque cardiogénico ser uma ocorrência rara na MT, caso ocorra, pode levar ao uso de dispositivos de assistência ventricular esquerda.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Reportamos o caso de uma doente com MT e choque cardiogénico onde foi utilizado suporte de vida extracorporal (SVEC). Com o SVEC foi possível reduzir o suporte aminérgico e documentada em ecocardiografia uma fração de ejeção normal ao 2.° dia.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">No conhecimento dos autores este é o primeiro caso, em Portugal, de choque cardiogénico por MT em que é usado o SVEC como ponte para a melhoria.</p></span>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 615 "Ancho" => 1501 "Tamanyo" => 86999 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Selective coronary angiography. Left (left) and right (right) coronary arteries, showing absence of coronary artery disease.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 650 "Ancho" => 1502 "Tamanyo" => 114681 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Left ventriculography during systole (left) and diastole (right).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Takotsubo-type cardiomyopathy due to multivessel spasm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 4 | 2 | 6 |
2024 October | 42 | 29 | 71 |
2024 September | 41 | 19 | 60 |
2024 August | 52 | 30 | 82 |
2024 July | 35 | 25 | 60 |
2024 June | 29 | 13 | 42 |
2024 May | 42 | 21 | 63 |
2024 April | 29 | 22 | 51 |
2024 March | 26 | 23 | 49 |
2024 February | 27 | 23 | 50 |
2024 January | 26 | 23 | 49 |
2023 December | 20 | 27 | 47 |
2023 November | 29 | 20 | 49 |
2023 October | 21 | 18 | 39 |
2023 September | 23 | 15 | 38 |
2023 August | 29 | 26 | 55 |
2023 July | 19 | 5 | 24 |
2023 June | 24 | 15 | 39 |
2023 May | 32 | 17 | 49 |
2023 April | 20 | 2 | 22 |
2023 March | 18 | 21 | 39 |
2023 February | 22 | 12 | 34 |
2023 January | 18 | 9 | 27 |
2022 December | 21 | 18 | 39 |
2022 November | 31 | 22 | 53 |
2022 October | 23 | 16 | 39 |
2022 September | 24 | 23 | 47 |
2022 August | 27 | 24 | 51 |
2022 July | 37 | 33 | 70 |
2022 June | 25 | 27 | 52 |
2022 May | 22 | 27 | 49 |
2022 April | 31 | 26 | 57 |
2022 March | 29 | 33 | 62 |
2022 February | 25 | 23 | 48 |
2022 January | 35 | 20 | 55 |
2021 December | 23 | 27 | 50 |
2021 November | 29 | 33 | 62 |
2021 October | 31 | 34 | 65 |
2021 September | 29 | 29 | 58 |
2021 August | 22 | 35 | 57 |
2021 July | 16 | 21 | 37 |
2021 June | 17 | 24 | 41 |
2021 May | 31 | 34 | 65 |
2021 April | 42 | 20 | 62 |
2021 March | 66 | 10 | 76 |
2021 February | 62 | 18 | 80 |
2021 January | 31 | 15 | 46 |
2020 December | 39 | 15 | 54 |
2020 November | 36 | 19 | 55 |
2020 October | 40 | 24 | 64 |
2020 September | 73 | 19 | 92 |
2020 August | 26 | 9 | 35 |
2020 July | 47 | 14 | 61 |
2020 June | 36 | 19 | 55 |
2020 May | 47 | 5 | 52 |
2020 April | 32 | 12 | 44 |
2020 March | 63 | 12 | 75 |
2020 February | 126 | 15 | 141 |
2020 January | 54 | 12 | 66 |
2019 December | 75 | 20 | 95 |
2019 November | 53 | 10 | 63 |
2019 October | 54 | 7 | 61 |
2019 September | 82 | 15 | 97 |
2019 August | 37 | 8 | 45 |
2019 July | 33 | 10 | 43 |
2019 June | 43 | 21 | 64 |
2019 May | 54 | 16 | 70 |
2019 April | 29 | 19 | 48 |
2019 March | 95 | 8 | 103 |
2019 February | 82 | 10 | 92 |
2019 January | 87 | 7 | 94 |
2018 December | 76 | 10 | 86 |
2018 November | 123 | 19 | 142 |
2018 October | 199 | 19 | 218 |
2018 September | 42 | 9 | 51 |
2018 August | 34 | 15 | 49 |
2018 July | 30 | 6 | 36 |
2018 June | 26 | 8 | 34 |
2018 May | 33 | 8 | 41 |
2018 April | 42 | 6 | 48 |
2018 March | 38 | 6 | 44 |
2018 February | 22 | 10 | 32 |
2018 January | 24 | 8 | 32 |
2017 December | 37 | 5 | 42 |
2017 November | 27 | 7 | 34 |
2017 October | 26 | 15 | 41 |
2017 September | 30 | 7 | 37 |
2017 August | 38 | 13 | 51 |
2017 July | 29 | 9 | 38 |
2017 June | 37 | 7 | 44 |
2017 May | 41 | 15 | 56 |
2017 April | 24 | 7 | 31 |
2017 March | 25 | 14 | 39 |
2017 February | 21 | 8 | 29 |
2017 January | 24 | 4 | 28 |
2016 December | 34 | 15 | 49 |
2016 November | 26 | 11 | 37 |
2016 October | 30 | 7 | 37 |
2016 September | 11 | 4 | 15 |
2016 August | 3 | 0 | 3 |
2016 July | 8 | 5 | 13 |
2016 June | 8 | 3 | 11 |
2016 May | 10 | 10 | 20 |
2016 April | 18 | 1 | 19 |
2016 March | 11 | 17 | 28 |
2016 February | 32 | 22 | 54 |
2016 January | 20 | 15 | 35 |
2015 December | 14 | 4 | 18 |