array:25 [
  "pii" => "S2174204915001567"
  "issn" => "21742049"
  "doi" => "10.1016/j.repce.2015.07.002"
  "estado" => "S300"
  "fechaPublicacion" => "2015-09-01"
  "aid" => "614"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "crp"
  "cita" => "Rev Port Cardiol. 2015;34:557.e1-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3663
    "formatos" => array:3 [
      "EPUB" => 163
      "HTML" => 2741
      "PDF" => 759
    ]
  ]
  "Traduccion" => array:1 [
    "pt" => array:20 [
      "pii" => "S0870255115000645"
      "issn" => "08702551"
      "doi" => "10.1016/j.repc.2015.01.006"
      "estado" => "S300"
      "fechaPublicacion" => "2015-09-01"
      "aid" => "614"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "crp"
      "cita" => "Rev Port Cardiol. 2015;34:557.e1-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 4489
        "formatos" => array:3 [
          "EPUB" => 168
          "HTML" => 3560
          "PDF" => 761
        ]
      ]
      "pt" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Caso cl&#237;nico</span>"
        "titulo" => "Intoxica&#231;&#227;o por mon&#243;xido de carbono com compromisso card&#237;aco&#58; o que sabemos&#63;"
        "tienePdf" => "pt"
        "tieneTextoCompleto" => "pt"
        "tieneResumen" => array:2 [
          0 => "pt"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "557&#46;e1"
            "paginaFinal" => "557&#46;e5"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "What do we know about carbon monoxide poisoning and cardiac compromise&#63;"
          ]
        ]
        "contieneResumen" => array:2 [
          "pt" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "pt" => true
        ]
        "contienePdf" => array:1 [
          "pt" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 874
                "Ancho" => 1500
                "Tamanyo" => 167306
              ]
            ]
            "descripcion" => array:1 [
              "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Eletrocardiograma &#224; entrada no servi&#231;o de urg&#234;ncia&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Rosa Cardiga, Margarida Proen&#231;a, Carolina Carvalho, Lu&#237;s Costa, Arturo Botella, Filipa Marques, Carolina Paulino, Ant&#243;nio Carvalho, C&#226;ndida Fonseca"
            "autores" => array:9 [
              0 => array:2 [
                "nombre" => "Rosa"
                "apellidos" => "Cardiga"
              ]
              1 => array:2 [
                "nombre" => "Margarida"
                "apellidos" => "Proen&#231;a"
              ]
              2 => array:2 [
                "nombre" => "Carolina"
                "apellidos" => "Carvalho"
              ]
              3 => array:2 [
                "nombre" => "Lu&#237;s"
                "apellidos" => "Costa"
              ]
              4 => array:2 [
                "nombre" => "Arturo"
                "apellidos" => "Botella"
              ]
              5 => array:2 [
                "nombre" => "Filipa"
                "apellidos" => "Marques"
              ]
              6 => array:2 [
                "nombre" => "Carolina"
                "apellidos" => "Paulino"
              ]
              7 => array:2 [
                "nombre" => "Ant&#243;nio"
                "apellidos" => "Carvalho"
              ]
              8 => array:2 [
                "nombre" => "C&#226;ndida"
                "apellidos" => "Fonseca"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "pt"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2174204915001567"
          "doi" => "10.1016/j.repce.2015.07.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001567?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115000645?idApp=UINPBA00004E"
      "url" => "/08702551/0000003400000009/v1_201509110034/S0870255115000645/v1_201509110034/pt/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2174204915001890"
    "issn" => "21742049"
    "doi" => "10.1016/j.repce.2015.08.009"
    "estado" => "S300"
    "fechaPublicacion" => "2015-09-01"
    "aid" => "672"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Rev Port Cardiol. 2015;34:559&#46;e1-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2451
      "formatos" => array:3 [
        "EPUB" => 141
        "HTML" => 1747
        "PDF" => 563
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Dyspnea in a nonagenarian&#58; The usual suspects&#44; an unexpected culprit"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "559&#46;e1"
          "paginaFinal" => "559&#46;e6"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0020"
          "etiqueta" => "Figure 4"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr4.jpeg"
              "Alto" => 1408
              "Ancho" => 3006
              "Tamanyo" => 214836
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Cine-fluoroscopy of percutaneous patent foramen ovale &#40;PFO&#41; closure&#58; &#40;A&#41; device delivery&#59; &#40;B&#41; absence of contrast flow through the septum after PFO closure&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "S&#233;rgio Madeira, Lu&#237;s Raposo, Raquel David, Alexandre Marques, Jos&#233; Andrade Gomes, Nuno Cardim, Rui Anjos"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "S&#233;rgio"
              "apellidos" => "Madeira"
            ]
            1 => array:2 [
              "nombre" => "Lu&#237;s"
              "apellidos" => "Raposo"
            ]
            2 => array:2 [
              "nombre" => "Raquel"
              "apellidos" => "David"
            ]
            3 => array:2 [
              "nombre" => "Alexandre"
              "apellidos" => "Marques"
            ]
            4 => array:2 [
              "nombre" => "Jos&#233;"
              "apellidos" => "Andrade Gomes"
            ]
            5 => array:2 [
              "nombre" => "Nuno"
              "apellidos" => "Cardim"
            ]
            6 => array:2 [
              "nombre" => "Rui"
              "apellidos" => "Anjos"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0870255115001857"
        "doi" => "10.1016/j.repc.2015.01.018"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115001857?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001890?idApp=UINPBA00004E"
    "url" => "/21742049/0000003400000009/v1_201509130054/S2174204915001890/v1_201509130054/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2174204915001889"
    "issn" => "21742049"
    "doi" => "10.1016/j.repce.2015.08.008"
    "estado" => "S300"
    "fechaPublicacion" => "2015-09-01"
    "aid" => "675"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Rev Port Cardiol. 2015;34:555&#46;e1-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4427
      "formatos" => array:3 [
        "EPUB" => 193
        "HTML" => 3634
        "PDF" => 600
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Endovascular management of IVC syndrome after IVC filter placement"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "555&#46;e1"
          "paginaFinal" => "555&#46;e4"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Tratamento endovascular da s&#237;ndrome da veia cava inferior ap&#243;s coloca&#231;&#227;o do filtro da veia cava inferior"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 2586
              "Ancho" => 3169
              "Tamanyo" => 456865
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Right femoral venogram&#59; &#40;B&#41; left femoral venogram through Quick-Cross catheter demonstrating IVC interruption at the level of the IVC filter&#59; &#40;C&#41; selective IVC venogram through Quick-Cross catheter above the IVC filter showing IVC stenosis&#59; &#40;D and E&#41; balloon angioplasty of the IVC and right femoral vein through the IVC filter&#59; &#40;F&#41; angiogram after percutaneous balloon angioplasty&#59; &#40;G and H&#41; angiogram after stent placement&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Konstantinos Marmagkiolis, Vasili Lendel, Mehmet Cilingiroglu"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Konstantinos"
              "apellidos" => "Marmagkiolis"
            ]
            1 => array:2 [
              "nombre" => "Vasili"
              "apellidos" => "Lendel"
            ]
            2 => array:2 [
              "nombre" => "Mehmet"
              "apellidos" => "Cilingiroglu"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0870255115001882"
        "doi" => "10.1016/j.repc.2015.01.019"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115001882?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001889?idApp=UINPBA00004E"
    "url" => "/21742049/0000003400000009/v1_201509130054/S2174204915001889/v1_201509130054/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
    "titulo" => "What do we know about carbon monoxide poisoning and cardiac compromise&#63; Treatment and prognosis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "557&#46;e1"
        "paginaFinal" => "557&#46;e5"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Rosa Cardiga, Margarida Proen&#231;a, Carolina Carvalho, Lu&#237;s Costa, Arturo Botella, Filipa Marques, Carolina Paulino, Ant&#243;nio Carvalho, C&#226;ndida Fonseca"
        "autores" => array:9 [
          0 => array:4 [
            "nombre" => "Rosa"
            "apellidos" => "Cardiga"
            "email" => array:1 [
              0 => "rosita&#46;cardiga&#64;gmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Margarida"
            "apellidos" => "Proen&#231;a"
          ]
          2 => array:2 [
            "nombre" => "Carolina"
            "apellidos" => "Carvalho"
          ]
          3 => array:2 [
            "nombre" => "Lu&#237;s"
            "apellidos" => "Costa"
          ]
          4 => array:2 [
            "nombre" => "Arturo"
            "apellidos" => "Botella"
          ]
          5 => array:2 [
            "nombre" => "Filipa"
            "apellidos" => "Marques"
          ]
          6 => array:2 [
            "nombre" => "Carolina"
            "apellidos" => "Paulino"
          ]
          7 => array:2 [
            "nombre" => "Ant&#243;nio"
            "apellidos" => "Carvalho"
          ]
          8 => array:2 [
            "nombre" => "C&#226;ndida"
            "apellidos" => "Fonseca"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servi&#231;o de Medicina III&#44; Hospital S&#227;o Francisco Xavier&#44; Centro Hospitalar de Lisboa Ocidental&#44; Faculdade de Ci&#234;ncias M&#233;dicas&#44; Universidade Nova de Lisboa&#44; Lisboa&#44; Portugal"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Intoxica&#231;&#227;o por mon&#243;xido de carbono com compromisso card&#237;aco&#58; o que sabemos&#63;"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 874
            "Ancho" => 1500
            "Tamanyo" => 178975
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Electrocardiogram 15 h after admission to the emergency room&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Carbon monoxide &#40;CO&#41; is a colorless&#44; tasteless&#44; odorless and non-irritant but highly toxic gas&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">1</span></a> It binds rapidly to hemoglobin with an affinity 210 times higher than for oxygen&#44; leading to the formation of carboxyhemoglobin &#40;COHb&#41; and tissue hypoxia&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">CO poisoning is one of the most common types of poisoning&#59; it is a frequent cause of morbidity&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">2</span></a> and the leading cause of death by poisoning worldwide&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">While not a common cause of hospital admission in Portugal&#44; its incidence is not negligible&#58; 5&#46;86&#47;100<span class="elsevierStyleHsp" style=""></span>000 population over an eight-year period&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The clinical symptoms of CO poisoning are non-specific and can mimic a wide range of conditions&#44; and diagnosis requires a high index of suspicion&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Headache is the most common symptom of CO poisoning&#44; reported in 84&#37; of cases&#44; and 50&#37; of patients present fatigue&#44; nausea&#44; mental confusion and dyspnea&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">1</span></a> Less frequent symptoms include abdominal pain&#44; visual disturbances&#44; chest pain and seizures&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Tissue hypoxia in CO poisoning affects all organs and systems&#44; and involvement of the major organs worsens prognosis&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The neurological sequelae of CO poisoning have been amply described in the literature&#44; but cardiovascular repercussions have only been presented in occasional case reports&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Cardiac injury results from the binding of CO to hemoglobin and myoglobin and inhibition of mitochondrial cytochrome oxidase&#44; resulting in tissue hypoxia and reduced adenosine triphosphate synthesis&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">7</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The most common cardiac manifestations are ischemia leading to elevated myocardial necrosis markers&#44; electrocardiographic &#40;ECG&#41; alterations&#44; particularly ST-segment depression&#44; myocardial infarction and conduction disturbances such as atrial fibrillation and ventricular arrhythmias&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The authors present a case of CO poisoning with cardiac compromise with the aim of highlighting the seriousness of this complication&#44; which is frequently overlooked&#44; and the need for thorough investigation and monitoring in all cases of CO poisoning&#46; The indication for hyperbaric therapy is also discussed in this context&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0055" class="elsevierStylePara elsevierViewall">A 27-year-old woman&#44; with no relevant clinical history or cardiovascular risk factors and not taking any medication&#44; was admitted to the emergency room &#40;ER&#41; due to an episode of lipothymia&#44; during which she was unable to move for around two hours following a bath&#46; She denied loss of consciousness&#44; tonic&#8211;clonic movements&#44; loss of sphincter control&#44; chest pain or palpitations&#46; She reported holocranial headache for the previous two weeks&#44; which she quantified as 6 on a scale of 1 to 10&#44; associated with nausea and vomiting&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">9</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">From an epidemiological standpoint&#44; the patient was accompanied by two other women who lived in the same building and had similar symptoms&#46; They also reported that a dog living in the same place was suffering from collapse and vomiting&#46; There was no other relevant history&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">On physical examination&#44; the patient was conscious&#44; cooperative&#44; and oriented in time and space&#44; with blood pressure 109&#47;69 mmHg&#44; regular heart rate &#40;HR&#41; 109 bpm&#44; and no other significant alterations&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Blood gas analysis on room air revealed pH 7&#46;392&#44; pCO<span class="elsevierStyleInf">2</span> 32 mmHg&#44; pO<span class="elsevierStyleInf">2</span> 101 mmHg&#44; HCO<span class="elsevierStyleInf">3</span> 20&#46;8 mmol&#47;l&#44; COHb 29&#46;2&#37; and lactate 3&#46;5 mmol&#47;l&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows changes in laboratory values over the patient&#39;s three-day hospital stay&#46; Of note are the rises in markers of myocardial necrosis &#40;peak troponin 6&#46;13 &#956;g&#47;l&#44; 9 h after the event&#41;&#44; and in NT-proBNP&#44; which normalized on the third day&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">The ECG on admission to the ER &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41; showed sinus rhythm&#44; HR 110 bpm&#44; normal P-wave amplitude and duration&#44; with a 1&#58;1 A&#47;V ratio&#44; PR interval 131 ms&#44; QRS duration 90 ms&#44; and ST-segment depression of 2 mm in V4 and 1 mm in V5&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">The ECG 15 h after ER admission &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41; showed sinus rhythm and normal HR of 78 bpm&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Transthoracic echocardiography showed no left ventricular dilatation&#44; hypertrophy or wall motion abnormalities&#44; good global systolic function and ejection fraction of 65&#37;&#59; good right ventricular systolic function and tricuspid annular plane systolic excursion of 16 mm&#59; the other cardiac chambers were normal&#46; There were no valve abnormalities&#44; pericardial effusion or intracavitary masses&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Given the clinical and epidemiological context&#44; myocardial and central nervous system ischemia due to CO poisoning following prolonged exposure was assumed&#46; Normobaric oxygen therapy was started while the indication for hyperbaric oxygen therapy was discussed with the specialist responsible for the hyperbaric chamber&#44; who suggested maintaining conservative treatment and monitoring for 72 h&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">The patient&#39;s clinical course was favorable and she was discharged&#44; asymptomatic&#44; on the third day&#46; Laboratory tests revealed a fall in markers of myocardial necrosis and normalization of NT-proBNP &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Blood gas analysis on room air showed pH 7&#46;436&#44; pCO<span class="elsevierStyleInf">2</span> 35 mmHg&#44; pO<span class="elsevierStyleInf">2</span> 120 mmHg&#44; COHb 0&#46;5&#37; and HCO<span class="elsevierStyleInf">3</span> 23 mmol&#47;l&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0105" class="elsevierStylePara elsevierViewall">The case presented describes a less common complication of CO poisoning &#8211; myocardial and central nervous system ischemia&#46; The former is often overlooked&#44; with few and conflicting reports in the literature on the therapeutic approach to adopt&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">A search in Medline for articles on this subject published since January 1st&#44; 2000 produced 299 articles with the search term &#8220;carbon monoxide poisoning&#8221;&#44; 18 articles with &#8220;carbon monoxide poisoning and neurological effects&#8221; and 12 articles with &#8220;carbon monoxide poisoning and myocardial injury&#8221;&#44; which demonstrates the low level of attention paid to this subject&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">A study based on autopsies performed by the Portuguese National Institute of Legal Medicine over a six-year period from 2005 to 2011 recorded 111 deaths from CO poisoning &#8211; 55 in the North region&#44; 12 in the Central region and 44 in the South region&#46; Most deaths were the result of accidents in the home with open fires&#44; charcoal braziers and gas water heaters&#44; as was the case with our patient&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">10</span></a> The study did not specify the degree of injury to different organs&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Hampson et al&#46; demonstrated that there was no significant difference in short-term mortality from CO poisoning between patients treated with normobaric or hyperbaric oxygen therapy&#44; the aim of the latter being to prevent permanent organ damage&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">11</span></a> The indications for hyperbaric oxygen therapy remain the subject of debate and are currently restricted &#40;<a class="elsevierStyleCrossRef" href="#tbl0030">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0030"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">According to the latest international guidelines hyperbaric oxygen therapy should be used in all patients with severe CO poisoning&#44; severity being assessed on indicators of organ damage rather than simply on levels of COHb &#40;<a class="elsevierStyleCrossRef" href="#tbl0030">Table 2</a>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">12&#44;1</span></a> The myocardial ischemia observed in our patient is one of these indicators&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Satran et al&#46; demonstrated that myocardial injury is common in moderate to severe CO poisoning&#46; In a prospective study between January 1&#44; 1994 and January 1&#44; 2002&#44; with follow-up to November 11&#44; 2005&#44; they reviewed the cardiovascular manifestations of 230 consecutive patients admitted for moderate to severe CO poisoning to a hospital with facilities for hyperbaric oxygen therapy&#46; Mean age was 47&#46;2 years and 72&#37; were male&#46; Of the total study population&#44; 37&#37; &#40;85 patients&#41; had myocardial injury assessed by ECG or biomarkers despite a low incidence of cardiac risk factors&#44; as was the case in our patient&#46; The study showed that cardiac damage is often underestimated in CO poisoning&#58; serial assessment of cardiac biomarkers was not performed in 20&#37; of patients and echocardiograms were performed in only 53 of those with positive markers&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">13</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Henry et al&#46; assessed long-term mortality &#40;follow-up 3&#8211;11 years&#41; in the same population of 85 patients admitted for CO poisoning with associated myocardial injury&#46; Of these&#44; 38&#37; died&#44; compared to 15&#37; of those with no myocardial injury &#40;odds ratio 2&#46;1&#59; 95&#37; confidence interval 1&#46;2&#8211;3&#46;7&#59; p&#61;0&#46;009&#41;&#46; They concluded that the risk of mortality in patients with CO poisoning and cardiac involvement is twice that of patients without myocardial injury and three times that of controls with no history of CO poisoning&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">14</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In the case presented&#44; prolonged CO exposure&#44; elevated markers of myocardial necrosis and loss of consciousness&#44; indicators of central nervous system and myocardial damage&#44; led us to classify the CO poisoning as severe and to consider hyperbaric oxygen therapy&#46; However&#44; the severity of organ damage is based on the assessment of a specialist in hyperbaric medicine&#44; who in this case&#44; given the patient&#39;s clinical stability&#44; advised maintaining normobaric oxygen therapy and close monitoring&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The clinical course was favorable on high flow oxygen therapy&#44; and the patient survived and was still asymptomatic in cardiovascular terms at 400 days of follow-up&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Despite the scarcity of data in the literature&#44; CO poisoning is common&#46; Prognosis can be poor&#44; and appears to be dictated by the extent of involvement of the myocardium as well as of the central nervous system&#46; There have been few studies and the guidelines&#44; as their authors acknowledge&#44; are unclear due to lack of evidence&#44; particularly concerning the benefits of hyperbaric oxygen therapy and its indications&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Cardiac involvement is often underdiagnosed or overlooked&#44; which highlights the need to raise awareness of this complication among health professionals&#44; and of its implications for prognosis&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">New randomized studies are required to establish evidence-based guidelines&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Ethical disclosures</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Protection of human and animal subjects</span><p id="par0165" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Confidentiality of data</span><p id="par0170" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Right to privacy and informed consent</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflicts of interest</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:3 [
          "identificador" => "xres552155"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec569518"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres552154"
          "titulo" => "Resumo"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec569519"
          "titulo" => "Palavras-chave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Case report"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        7 => array:3 [
          "identificador" => "sec0020"
          "titulo" => "Ethical disclosures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Protection of human and animal subjects"
            ]
            1 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Confidentiality of data"
            ]
            2 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        8 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Conflicts of interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-10-09"
    "fechaAceptado" => "2015-01-02"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec569518"
          "palabras" => array:3 [
            0 => "Carbon monoxide poisoning"
            1 => "Myocardial ischemia"
            2 => "Hyperbaric oxygen"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec569519"
          "palabras" => array:3 [
            0 => "Intoxica&#231;&#227;o por mon&#243;xido de carbono"
            1 => "Isquemia do mioc&#225;rdio"
            2 => "Oxig&#233;nio hiperb&#225;rico"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Carbon monoxide &#40;CO&#41; poisoning is one of the most common types of poisoning and the leading cause of death by poisoning worldwide&#46; Cardiac injury caused by CO poisoning has been little described despite being a predictor of poor prognosis&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We present the case of a healthy 24-year-old woman&#44; admitted to our emergency room due to an episode of lipothymia without loss of consciousness&#46; She reported holocranial headache for the previous two weeks associated with nausea and vomiting&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Laboratory tests revealed blood gas analysis&#58; pH 7&#46;392&#44; pCO<span class="elsevierStyleInf">2</span> 32 mmHg&#44; pO<span class="elsevierStyleInf">2</span> 101 mmHg&#44; lactate 3&#46;5 mmol&#47;l&#44; HCO<span class="elsevierStyleInf">3</span> 20&#46;8 mmol&#47;l&#59; COHb 29&#46;2&#37;&#59; serial troponin I 1&#46;21&#8594;5&#46;25&#8594;6&#46;13&#8594;3&#46;65 &#956;g&#47;l&#59; myoglobin 1378&#8594;964&#8594;352 &#956;g&#47;l&#59; and NT-proBNP 1330 pg&#47;l&#46; The electrocardiogram showed sinus rhythm&#44; heart rate 110 bpm&#44; and ST-segment depression of 2 mm in V4 and 1 mm in V5&#46; Transthoracic echocardiography revealed a left ventricle with normal wall motion and preserved ejection fraction&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Given the clinical and epidemiological context&#44; myocardial and central nervous system ischemia due to prolonged CO exposure was assumed and normobaric oxygen therapy was immediately started&#46; In view of evidence of injury to two major organ systems the indication for hyperbaric oxygen therapy was discussed with a specialist colleague&#44; who suggested maintaining conservative treatment with oxygen therapy and in-hospital monitoring for 72 h&#46; The patient was discharged on the third day and was still asymptomatic at 400 days of follow-up&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Besides symptoms and signs of central nervous system dysfunction&#44; myocardial damage should also always be considered in the context of CO poisoning&#46; Hyperbaric therapy is still controversial and the lack of objective data highlights the need for new randomized studies&#46;</p></span>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A intoxica&#231;&#227;o por mon&#243;xido de carbono &#40;MC&#41; &#233; um dos tipos de intoxica&#231;&#227;o mais frequente e a principal causa de morte por intoxica&#231;&#227;o no mundo&#46; A les&#227;o card&#237;aca provocada pela intoxica&#231;&#227;o por MC tem sido pouco descrita apesar de ser um fator preditor de mau progn&#243;stico&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Apresentamos o caso de uma mulher de 24 anos&#44; saud&#225;vel&#44; que recorre ao servi&#231;o de urg&#234;ncia por lipotimia sem perda de conhecimento&#46; Referia cefaleia holocraniana associada a n&#225;useas e v&#243;mitos com duas semanas de evolu&#231;&#227;o&#46; Analiticamente&#58; gasimetria pH 7&#44;392&#59; pCO<span class="elsevierStyleInf">2</span> 32 mmHg&#44; pO<span class="elsevierStyleInf">2</span> 101 mmHg&#44; lactatos 3&#44;5 mmol&#47;L&#44; HCO<span class="elsevierStyleInf">3</span> 20&#44;8 mmol&#47;L&#44; COHb 29&#44;2&#37;&#59; troponina I seriada 1&#44;21&#8594;5&#44;25&#8594;6&#44;13&#8594;3&#44;65 ug&#47;L&#44; mioglobina 1378&#8594;964&#8594;352 ug&#47;L&#44; NT-ProBNP 1330 pg&#47;L&#46; Eletrocardiograma&#58; ritmo sinusal&#44; frequ&#234;ncia card&#237;aca 110 bpm&#44; depress&#227;o do segmento ST de 2 mm em V4 e 1 mm em V5&#46; Ecocardiograma transtor&#225;cico&#58; ventr&#237;culo esquerdo sem altera&#231;&#245;es da cin&#233;tica segmentar e boa fun&#231;&#227;o sist&#243;lica global&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Associando-se a cl&#237;nica ao contexto epidemiol&#243;gico assumiu-se isquemia do mioc&#225;rdio e do sistema nervoso central por exposi&#231;&#227;o prolongada ao MC&#46; Iniciou-se prontamente oxigenoterapia normob&#225;rica&#46; Perante a evid&#234;ncia de compromisso de dois &#243;rg&#227;os nobres&#44; foi discutida com o colega especialista nesta &#225;rea a indica&#231;&#227;o para tratamento com oxig&#233;nio hiperb&#225;rico&#44; sugeriu manter tratamento conservador com oxigenoterapia e vigil&#226;ncia em internamento durante 72 h&#46; Teve alta ao terceiro dia e mant&#233;m-se assintom&#225;tica aos 400 dias de follow-up&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Tal como os sintomas e sinais de disfun&#231;&#227;o do sistema nervoso central&#44; a les&#227;o do mioc&#225;rdio deve ser sistematicamente equacionada no contexto de intoxica&#231;&#227;o por MC&#46; A indica&#231;&#227;o para terap&#234;utica em c&#226;mara hiperb&#225;rica permanece controversa e com indica&#231;&#245;es pouco objetivas&#44; a apelar a novos estudos aleatorizados&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Cardiga R&#44; Proen&#231;a M&#44; Carvalho C&#44; et al&#46; Intoxica&#231;&#227;o por mon&#243;xido de carbono com compromisso card&#237;aco&#58; o que sabemos&#63; Rev Port Cardiol&#46; 2015&#59;34&#58;557&#46;e1&#8211;557&#46;e5&#46;</p>"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 874
            "Ancho" => 1500
            "Tamanyo" => 181900
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Electrocardiogram on admission to the emergency room&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 874
            "Ancho" => 1500
            "Tamanyo" => 178975
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Electrocardiogram 15 h after admission to the emergency room&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">D1&#58; one day after event&#59; D2&#58; two days after event&#59; D3&#58; three days after event&#59; H0&#58; at emergency room admission&#59; H6&#58; 6 h after event&#59; H9&#58; 9 h after event&#59; H20&#58; 20 h after event&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">H0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">H6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">H9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">H20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">D1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">D2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">D3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hemoglobin &#40;g&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Leukocytes &#40;&#215;10<span class="elsevierStyleSup">9</span>&#47;l&#41;&#47;neutrophils &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&#46;8&#47;93&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#46;6&#47;13&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;1&#47;47&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#46;8&#47;5&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">C-reactive protein &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Creatininemia &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Troponinemia &#40;&#956;g&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Creatine kinase &#40;U&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2164&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3058&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">791&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Myoglobinemia &#40;&#956;g&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1378&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">964&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">352&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">NT-proBNP &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1330&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">384&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab891420.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Changes in laboratory values during hospital stay&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0030"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Loss of consciousness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Neurological deficits&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Ischemic cardiac changes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Metabolic acidosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Carboxyhemoglobin &#62;25&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab891421.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Indications for hyperbaric oxygen therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">12</span></a></p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:14 [
            0 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carbon monoxide intoxication&#58; an updated review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;D&#46; Prockop"
                            1 => "R&#46;I&#46; Chichkova"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jns.2007.06.037"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Sci"
                        "fecha" => "2007"
                        "volumen" => "262"
                        "paginaInicial" => "122"
                        "paginaFinal" => "130"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17720201"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Unintentional carbon monoxide-related deaths in the United States&#44; 1979 through 1988"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46; Cobb"
                            1 => "R&#46;A&#46; Etzel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1991"
                        "volumen" => "266"
                        "paginaInicial" => "659"
                        "paginaFinal" => "663"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1712865"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trends in the incidence of carbon monoxide poisoning in the United States"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "N&#46;B&#46; Hampson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajem.2005.03.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Emerg Med"
                        "fecha" => "2005"
                        "volumen" => "23"
                        "paginaInicial" => "838"
                        "paginaFinal" => "841"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16291437"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Internamentos por intoxica&#231;&#227;o com mon&#243;xido de carbono em Portugal"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;C&#46; S&#225;"
                            1 => "R&#46;P&#46; Rodrigues"
                            2 => "R&#46; Moura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Med Port"
                        "fecha" => "2011"
                        "volumen" => "24"
                        "paginaInicial" => "727"
                        "paginaFinal" => "734"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22525624"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Myocardial toxicity from carbon monoxide poisoning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;F&#46; Anderson"
                            1 => "D&#46;C&#46; Allensworth"
                            2 => "W&#46;J&#46; de Groot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1967"
                        "volumen" => "67"
                        "paginaInicial" => "1172"
                        "paginaFinal" => "1182"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6061932"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The electrocardiographic changes found in 22 cases of carbon monoxide poisoning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46;H&#46; Stearns"
                            1 => "C&#46;K&#46; Drinker"
                            2 => "T&#46;J&#46; Shaughnessy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1938"
                        "volumen" => "15"
                        "paginaInicial" => "434"
                        "paginaFinal" => "447"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mitochondrial cytochrome c oxidase inhibition during acute carbon monoxide poisoning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "O&#46; Miro"
                            1 => "J&#46; Casademont"
                            2 => "A&#46; Barrientos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacol Toxicol"
                        "fecha" => "1998"
                        "volumen" => "82"
                        "paginaInicial" => "199"
                        "paginaFinal" => "202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9584335"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carbon monoxide poisoning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Ernst"
                            1 => "J&#46;D&#46; Zibrak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199811263392206"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1998"
                        "volumen" => "339"
                        "paginaInicial" => "1603"
                        "paginaFinal" => "1608"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9828249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Dor como 5&#176; Sinal Vital&#44; Registo Sistem&#225;tico da Intensidade da Dor&#59; Dire&#231;&#227;o Geral da Sa&#250;de 2011&#46;"
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Intoxica&#231;&#227;o&#58; Mais de 100 pessoas morreram nos &#250;ltimos seis anos&#46; Correio da Manh&#227;&#44; January 31&#44; 2012&#46;"
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk factors for short-term mortality from carbon monoxide poisoning treated with hyperbaric oxygen"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46;B&#46; Hampson"
                            1 => "N&#46;M&#46; Hauff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/CCM.0b013e31818419d8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "2008"
                        "volumen" => "36"
                        "paginaInicial" => "2523"
                        "paginaFinal" => "2527"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18679118"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Practice recommendations in the diagnosis&#44; management&#44; and prevention of carbon monoxide poisoning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "N&#46;B&#46; Hampson"
                            1 => "C&#46;A&#46; Piantadosi"
                            2 => "S&#46;R&#46; Thom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201207-1284CI"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2012"
                        "volumen" => "186"
                        "paginaInicial" => "1095"
                        "paginaFinal" => "1101"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23087025"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular manifestations of moderate to severe carbon monoxide poisoning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46; Satran"
                            1 => "C&#46;R&#46; Henry"
                            2 => "C&#46; Adkinson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "JACC"
                        "fecha" => "2005"
                        "volumen" => "5"
                        "paginaInicial" => "1513"
                        "paginaFinal" => "1516"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Myocardial injury and long-term mortality following moderate to severe carbon monoxide poisoning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;R&#46; Henry"
                            1 => "D&#46; Satran"
                            2 => "B&#46; Lindgren"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.295.4.398"
                      "Revista" => array:5 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2006"
                        "volumen" => "295"
                        "paginaInicial" => "398"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16434630"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21742049/0000003400000009/v1_201509130054/S2174204915001567/v1_201509130054/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9914"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case report"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21742049/0000003400000009/v1_201509130054/S2174204915001567/v1_201509130054/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001567?idApp=UINPBA00004E"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case report
What do we know about carbon monoxide poisoning and cardiac compromise? Treatment and prognosis
Intoxicação por monóxido de carbono com compromisso cardíaco: o que sabemos?
Rosa Cardiga
Corresponding author
rosita.cardiga@gmail.com

Corresponding author.
, Margarida Proença, Carolina Carvalho, Luís Costa, Arturo Botella, Filipa Marques, Carolina Paulino, António Carvalho, Cândida Fonseca
Serviço de Medicina III, Hospital São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal
Read
8906
Times
was read the article
2279
Total PDF
6627
Total HTML
Share statistics
 array:25 [
  "pii" => "S2174204915001567"
  "issn" => "21742049"
  "doi" => "10.1016/j.repce.2015.07.002"
  "estado" => "S300"
  "fechaPublicacion" => "2015-09-01"
  "aid" => "614"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "crp"
  "cita" => "Rev Port Cardiol. 2015;34:557&#46;e1-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3663
    "formatos" => array:3 [
      "EPUB" => 163
      "HTML" => 2741
      "PDF" => 759
    ]
  ]
  "Traduccion" => array:1 [
    "pt" => array:20 [
      "pii" => "S0870255115000645"
      "issn" => "08702551"
      "doi" => "10.1016/j.repc.2015.01.006"
      "estado" => "S300"
      "fechaPublicacion" => "2015-09-01"
      "aid" => "614"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "crp"
      "cita" => "Rev Port Cardiol. 2015;34:557&#46;e1-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 4489
        "formatos" => array:3 [
          "EPUB" => 168
          "HTML" => 3560
          "PDF" => 761
        ]
      ]
      "pt" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Caso cl&#237;nico</span>"
        "titulo" => "Intoxica&#231;&#227;o por mon&#243;xido de carbono com compromisso card&#237;aco&#58; o que sabemos&#63;"
        "tienePdf" => "pt"
        "tieneTextoCompleto" => "pt"
        "tieneResumen" => array:2 [
          0 => "pt"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "557&#46;e1"
            "paginaFinal" => "557&#46;e5"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "What do we know about carbon monoxide poisoning and cardiac compromise&#63;"
          ]
        ]
        "contieneResumen" => array:2 [
          "pt" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "pt" => true
        ]
        "contienePdf" => array:1 [
          "pt" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 874
                "Ancho" => 1500
                "Tamanyo" => 167306
              ]
            ]
            "descripcion" => array:1 [
              "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Eletrocardiograma &#224; entrada no servi&#231;o de urg&#234;ncia&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Rosa Cardiga, Margarida Proen&#231;a, Carolina Carvalho, Lu&#237;s Costa, Arturo Botella, Filipa Marques, Carolina Paulino, Ant&#243;nio Carvalho, C&#226;ndida Fonseca"
            "autores" => array:9 [
              0 => array:2 [
                "nombre" => "Rosa"
                "apellidos" => "Cardiga"
              ]
              1 => array:2 [
                "nombre" => "Margarida"
                "apellidos" => "Proen&#231;a"
              ]
              2 => array:2 [
                "nombre" => "Carolina"
                "apellidos" => "Carvalho"
              ]
              3 => array:2 [
                "nombre" => "Lu&#237;s"
                "apellidos" => "Costa"
              ]
              4 => array:2 [
                "nombre" => "Arturo"
                "apellidos" => "Botella"
              ]
              5 => array:2 [
                "nombre" => "Filipa"
                "apellidos" => "Marques"
              ]
              6 => array:2 [
                "nombre" => "Carolina"
                "apellidos" => "Paulino"
              ]
              7 => array:2 [
                "nombre" => "Ant&#243;nio"
                "apellidos" => "Carvalho"
              ]
              8 => array:2 [
                "nombre" => "C&#226;ndida"
                "apellidos" => "Fonseca"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "pt"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2174204915001567"
          "doi" => "10.1016/j.repce.2015.07.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001567?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115000645?idApp=UINPBA00004E"
      "url" => "/08702551/0000003400000009/v1_201509110034/S0870255115000645/v1_201509110034/pt/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2174204915001890"
    "issn" => "21742049"
    "doi" => "10.1016/j.repce.2015.08.009"
    "estado" => "S300"
    "fechaPublicacion" => "2015-09-01"
    "aid" => "672"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Rev Port Cardiol. 2015;34:559&#46;e1-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2451
      "formatos" => array:3 [
        "EPUB" => 141
        "HTML" => 1747
        "PDF" => 563
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Dyspnea in a nonagenarian&#58; The usual suspects&#44; an unexpected culprit"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "559&#46;e1"
          "paginaFinal" => "559&#46;e6"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0020"
          "etiqueta" => "Figure 4"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr4.jpeg"
              "Alto" => 1408
              "Ancho" => 3006
              "Tamanyo" => 214836
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Cine-fluoroscopy of percutaneous patent foramen ovale &#40;PFO&#41; closure&#58; &#40;A&#41; device delivery&#59; &#40;B&#41; absence of contrast flow through the septum after PFO closure&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "S&#233;rgio Madeira, Lu&#237;s Raposo, Raquel David, Alexandre Marques, Jos&#233; Andrade Gomes, Nuno Cardim, Rui Anjos"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "S&#233;rgio"
              "apellidos" => "Madeira"
            ]
            1 => array:2 [
              "nombre" => "Lu&#237;s"
              "apellidos" => "Raposo"
            ]
            2 => array:2 [
              "nombre" => "Raquel"
              "apellidos" => "David"
            ]
            3 => array:2 [
              "nombre" => "Alexandre"
              "apellidos" => "Marques"
            ]
            4 => array:2 [
              "nombre" => "Jos&#233;"
              "apellidos" => "Andrade Gomes"
            ]
            5 => array:2 [
              "nombre" => "Nuno"
              "apellidos" => "Cardim"
            ]
            6 => array:2 [
              "nombre" => "Rui"
              "apellidos" => "Anjos"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0870255115001857"
        "doi" => "10.1016/j.repc.2015.01.018"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115001857?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001890?idApp=UINPBA00004E"
    "url" => "/21742049/0000003400000009/v1_201509130054/S2174204915001890/v1_201509130054/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2174204915001889"
    "issn" => "21742049"
    "doi" => "10.1016/j.repce.2015.08.008"
    "estado" => "S300"
    "fechaPublicacion" => "2015-09-01"
    "aid" => "675"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Rev Port Cardiol. 2015;34:555&#46;e1-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4427
      "formatos" => array:3 [
        "EPUB" => 193
        "HTML" => 3634
        "PDF" => 600
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Endovascular management of IVC syndrome after IVC filter placement"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "555&#46;e1"
          "paginaFinal" => "555&#46;e4"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Tratamento endovascular da s&#237;ndrome da veia cava inferior ap&#243;s coloca&#231;&#227;o do filtro da veia cava inferior"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 2586
              "Ancho" => 3169
              "Tamanyo" => 456865
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Right femoral venogram&#59; &#40;B&#41; left femoral venogram through Quick-Cross catheter demonstrating IVC interruption at the level of the IVC filter&#59; &#40;C&#41; selective IVC venogram through Quick-Cross catheter above the IVC filter showing IVC stenosis&#59; &#40;D and E&#41; balloon angioplasty of the IVC and right femoral vein through the IVC filter&#59; &#40;F&#41; angiogram after percutaneous balloon angioplasty&#59; &#40;G and H&#41; angiogram after stent placement&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Konstantinos Marmagkiolis, Vasili Lendel, Mehmet Cilingiroglu"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Konstantinos"
              "apellidos" => "Marmagkiolis"
            ]
            1 => array:2 [
              "nombre" => "Vasili"
              "apellidos" => "Lendel"
            ]
            2 => array:2 [
              "nombre" => "Mehmet"
              "apellidos" => "Cilingiroglu"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0870255115001882"
        "doi" => "10.1016/j.repc.2015.01.019"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115001882?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001889?idApp=UINPBA00004E"
    "url" => "/21742049/0000003400000009/v1_201509130054/S2174204915001889/v1_201509130054/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
    "titulo" => "What do we know about carbon monoxide poisoning and cardiac compromise&#63; Treatment and prognosis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "557&#46;e1"
        "paginaFinal" => "557&#46;e5"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Rosa Cardiga, Margarida Proen&#231;a, Carolina Carvalho, Lu&#237;s Costa, Arturo Botella, Filipa Marques, Carolina Paulino, Ant&#243;nio Carvalho, C&#226;ndida Fonseca"
        "autores" => array:9 [
          0 => array:4 [
            "nombre" => "Rosa"
            "apellidos" => "Cardiga"
            "email" => array:1 [
              0 => "rosita&#46;cardiga&#64;gmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Margarida"
            "apellidos" => "Proen&#231;a"
          ]
          2 => array:2 [
            "nombre" => "Carolina"
            "apellidos" => "Carvalho"
          ]
          3 => array:2 [
            "nombre" => "Lu&#237;s"
            "apellidos" => "Costa"
          ]
          4 => array:2 [
            "nombre" => "Arturo"
            "apellidos" => "Botella"
          ]
          5 => array:2 [
            "nombre" => "Filipa"
            "apellidos" => "Marques"
          ]
          6 => array:2 [
            "nombre" => "Carolina"
            "apellidos" => "Paulino"
          ]
          7 => array:2 [
            "nombre" => "Ant&#243;nio"
            "apellidos" => "Carvalho"
          ]
          8 => array:2 [
            "nombre" => "C&#226;ndida"
            "apellidos" => "Fonseca"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servi&#231;o de Medicina III&#44; Hospital S&#227;o Francisco Xavier&#44; Centro Hospitalar de Lisboa Ocidental&#44; Faculdade de Ci&#234;ncias M&#233;dicas&#44; Universidade Nova de Lisboa&#44; Lisboa&#44; Portugal"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Intoxica&#231;&#227;o por mon&#243;xido de carbono com compromisso card&#237;aco&#58; o que sabemos&#63;"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 874
            "Ancho" => 1500
            "Tamanyo" => 178975
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Electrocardiogram 15 h after admission to the emergency room&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Carbon monoxide &#40;CO&#41; is a colorless&#44; tasteless&#44; odorless and non-irritant but highly toxic gas&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">1</span></a> It binds rapidly to hemoglobin with an affinity 210 times higher than for oxygen&#44; leading to the formation of carboxyhemoglobin &#40;COHb&#41; and tissue hypoxia&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">CO poisoning is one of the most common types of poisoning&#59; it is a frequent cause of morbidity&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">2</span></a> and the leading cause of death by poisoning worldwide&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">While not a common cause of hospital admission in Portugal&#44; its incidence is not negligible&#58; 5&#46;86&#47;100<span class="elsevierStyleHsp" style=""></span>000 population over an eight-year period&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The clinical symptoms of CO poisoning are non-specific and can mimic a wide range of conditions&#44; and diagnosis requires a high index of suspicion&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Headache is the most common symptom of CO poisoning&#44; reported in 84&#37; of cases&#44; and 50&#37; of patients present fatigue&#44; nausea&#44; mental confusion and dyspnea&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">1</span></a> Less frequent symptoms include abdominal pain&#44; visual disturbances&#44; chest pain and seizures&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Tissue hypoxia in CO poisoning affects all organs and systems&#44; and involvement of the major organs worsens prognosis&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The neurological sequelae of CO poisoning have been amply described in the literature&#44; but cardiovascular repercussions have only been presented in occasional case reports&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Cardiac injury results from the binding of CO to hemoglobin and myoglobin and inhibition of mitochondrial cytochrome oxidase&#44; resulting in tissue hypoxia and reduced adenosine triphosphate synthesis&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">7</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The most common cardiac manifestations are ischemia leading to elevated myocardial necrosis markers&#44; electrocardiographic &#40;ECG&#41; alterations&#44; particularly ST-segment depression&#44; myocardial infarction and conduction disturbances such as atrial fibrillation and ventricular arrhythmias&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The authors present a case of CO poisoning with cardiac compromise with the aim of highlighting the seriousness of this complication&#44; which is frequently overlooked&#44; and the need for thorough investigation and monitoring in all cases of CO poisoning&#46; The indication for hyperbaric therapy is also discussed in this context&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0055" class="elsevierStylePara elsevierViewall">A 27-year-old woman&#44; with no relevant clinical history or cardiovascular risk factors and not taking any medication&#44; was admitted to the emergency room &#40;ER&#41; due to an episode of lipothymia&#44; during which she was unable to move for around two hours following a bath&#46; She denied loss of consciousness&#44; tonic&#8211;clonic movements&#44; loss of sphincter control&#44; chest pain or palpitations&#46; She reported holocranial headache for the previous two weeks&#44; which she quantified as 6 on a scale of 1 to 10&#44; associated with nausea and vomiting&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">9</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">From an epidemiological standpoint&#44; the patient was accompanied by two other women who lived in the same building and had similar symptoms&#46; They also reported that a dog living in the same place was suffering from collapse and vomiting&#46; There was no other relevant history&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">On physical examination&#44; the patient was conscious&#44; cooperative&#44; and oriented in time and space&#44; with blood pressure 109&#47;69 mmHg&#44; regular heart rate &#40;HR&#41; 109 bpm&#44; and no other significant alterations&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Blood gas analysis on room air revealed pH 7&#46;392&#44; pCO<span class="elsevierStyleInf">2</span> 32 mmHg&#44; pO<span class="elsevierStyleInf">2</span> 101 mmHg&#44; HCO<span class="elsevierStyleInf">3</span> 20&#46;8 mmol&#47;l&#44; COHb 29&#46;2&#37; and lactate 3&#46;5 mmol&#47;l&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows changes in laboratory values over the patient&#39;s three-day hospital stay&#46; Of note are the rises in markers of myocardial necrosis &#40;peak troponin 6&#46;13 &#956;g&#47;l&#44; 9 h after the event&#41;&#44; and in NT-proBNP&#44; which normalized on the third day&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">The ECG on admission to the ER &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41; showed sinus rhythm&#44; HR 110 bpm&#44; normal P-wave amplitude and duration&#44; with a 1&#58;1 A&#47;V ratio&#44; PR interval 131 ms&#44; QRS duration 90 ms&#44; and ST-segment depression of 2 mm in V4 and 1 mm in V5&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">The ECG 15 h after ER admission &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41; showed sinus rhythm and normal HR of 78 bpm&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Transthoracic echocardiography showed no left ventricular dilatation&#44; hypertrophy or wall motion abnormalities&#44; good global systolic function and ejection fraction of 65&#37;&#59; good right ventricular systolic function and tricuspid annular plane systolic excursion of 16 mm&#59; the other cardiac chambers were normal&#46; There were no valve abnormalities&#44; pericardial effusion or intracavitary masses&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Given the clinical and epidemiological context&#44; myocardial and central nervous system ischemia due to CO poisoning following prolonged exposure was assumed&#46; Normobaric oxygen therapy was started while the indication for hyperbaric oxygen therapy was discussed with the specialist responsible for the hyperbaric chamber&#44; who suggested maintaining conservative treatment and monitoring for 72 h&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">The patient&#39;s clinical course was favorable and she was discharged&#44; asymptomatic&#44; on the third day&#46; Laboratory tests revealed a fall in markers of myocardial necrosis and normalization of NT-proBNP &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Blood gas analysis on room air showed pH 7&#46;436&#44; pCO<span class="elsevierStyleInf">2</span> 35 mmHg&#44; pO<span class="elsevierStyleInf">2</span> 120 mmHg&#44; COHb 0&#46;5&#37; and HCO<span class="elsevierStyleInf">3</span> 23 mmol&#47;l&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0105" class="elsevierStylePara elsevierViewall">The case presented describes a less common complication of CO poisoning &#8211; myocardial and central nervous system ischemia&#46; The former is often overlooked&#44; with few and conflicting reports in the literature on the therapeutic approach to adopt&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">A search in Medline for articles on this subject published since January 1st&#44; 2000 produced 299 articles with the search term &#8220;carbon monoxide poisoning&#8221;&#44; 18 articles with &#8220;carbon monoxide poisoning and neurological effects&#8221; and 12 articles with &#8220;carbon monoxide poisoning and myocardial injury&#8221;&#44; which demonstrates the low level of attention paid to this subject&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">A study based on autopsies performed by the Portuguese National Institute of Legal Medicine over a six-year period from 2005 to 2011 recorded 111 deaths from CO poisoning &#8211; 55 in the North region&#44; 12 in the Central region and 44 in the South region&#46; Most deaths were the result of accidents in the home with open fires&#44; charcoal braziers and gas water heaters&#44; as was the case with our patient&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">10</span></a> The study did not specify the degree of injury to different organs&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Hampson et al&#46; demonstrated that there was no significant difference in short-term mortality from CO poisoning between patients treated with normobaric or hyperbaric oxygen therapy&#44; the aim of the latter being to prevent permanent organ damage&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">11</span></a> The indications for hyperbaric oxygen therapy remain the subject of debate and are currently restricted &#40;<a class="elsevierStyleCrossRef" href="#tbl0030">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0030"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">According to the latest international guidelines hyperbaric oxygen therapy should be used in all patients with severe CO poisoning&#44; severity being assessed on indicators of organ damage rather than simply on levels of COHb &#40;<a class="elsevierStyleCrossRef" href="#tbl0030">Table 2</a>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">12&#44;1</span></a> The myocardial ischemia observed in our patient is one of these indicators&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Satran et al&#46; demonstrated that myocardial injury is common in moderate to severe CO poisoning&#46; In a prospective study between January 1&#44; 1994 and January 1&#44; 2002&#44; with follow-up to November 11&#44; 2005&#44; they reviewed the cardiovascular manifestations of 230 consecutive patients admitted for moderate to severe CO poisoning to a hospital with facilities for hyperbaric oxygen therapy&#46; Mean age was 47&#46;2 years and 72&#37; were male&#46; Of the total study population&#44; 37&#37; &#40;85 patients&#41; had myocardial injury assessed by ECG or biomarkers despite a low incidence of cardiac risk factors&#44; as was the case in our patient&#46; The study showed that cardiac damage is often underestimated in CO poisoning&#58; serial assessment of cardiac biomarkers was not performed in 20&#37; of patients and echocardiograms were performed in only 53 of those with positive markers&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">13</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Henry et al&#46; assessed long-term mortality &#40;follow-up 3&#8211;11 years&#41; in the same population of 85 patients admitted for CO poisoning with associated myocardial injury&#46; Of these&#44; 38&#37; died&#44; compared to 15&#37; of those with no myocardial injury &#40;odds ratio 2&#46;1&#59; 95&#37; confidence interval 1&#46;2&#8211;3&#46;7&#59; p&#61;0&#46;009&#41;&#46; They concluded that the risk of mortality in patients with CO poisoning and cardiac involvement is twice that of patients without myocardial injury and three times that of controls with no history of CO poisoning&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">14</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In the case presented&#44; prolonged CO exposure&#44; elevated markers of myocardial necrosis and loss of consciousness&#44; indicators of central nervous system and myocardial damage&#44; led us to classify the CO poisoning as severe and to consider hyperbaric oxygen therapy&#46; However&#44; the severity of organ damage is based on the assessment of a specialist in hyperbaric medicine&#44; who in this case&#44; given the patient&#39;s clinical stability&#44; advised maintaining normobaric oxygen therapy and close monitoring&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The clinical course was favorable on high flow oxygen therapy&#44; and the patient survived and was still asymptomatic in cardiovascular terms at 400 days of follow-up&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Despite the scarcity of data in the literature&#44; CO poisoning is common&#46; Prognosis can be poor&#44; and appears to be dictated by the extent of involvement of the myocardium as well as of the central nervous system&#46; There have been few studies and the guidelines&#44; as their authors acknowledge&#44; are unclear due to lack of evidence&#44; particularly concerning the benefits of hyperbaric oxygen therapy and its indications&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Cardiac involvement is often underdiagnosed or overlooked&#44; which highlights the need to raise awareness of this complication among health professionals&#44; and of its implications for prognosis&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">New randomized studies are required to establish evidence-based guidelines&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Ethical disclosures</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Protection of human and animal subjects</span><p id="par0165" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Confidentiality of data</span><p id="par0170" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Right to privacy and informed consent</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflicts of interest</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:3 [
          "identificador" => "xres552155"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec569518"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres552154"
          "titulo" => "Resumo"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec569519"
          "titulo" => "Palavras-chave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Case report"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        7 => array:3 [
          "identificador" => "sec0020"
          "titulo" => "Ethical disclosures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Protection of human and animal subjects"
            ]
            1 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Confidentiality of data"
            ]
            2 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        8 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Conflicts of interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-10-09"
    "fechaAceptado" => "2015-01-02"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec569518"
          "palabras" => array:3 [
            0 => "Carbon monoxide poisoning"
            1 => "Myocardial ischemia"
            2 => "Hyperbaric oxygen"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec569519"
          "palabras" => array:3 [
            0 => "Intoxica&#231;&#227;o por mon&#243;xido de carbono"
            1 => "Isquemia do mioc&#225;rdio"
            2 => "Oxig&#233;nio hiperb&#225;rico"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Carbon monoxide &#40;CO&#41; poisoning is one of the most common types of poisoning and the leading cause of death by poisoning worldwide&#46; Cardiac injury caused by CO poisoning has been little described despite being a predictor of poor prognosis&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We present the case of a healthy 24-year-old woman&#44; admitted to our emergency room due to an episode of lipothymia without loss of consciousness&#46; She reported holocranial headache for the previous two weeks associated with nausea and vomiting&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Laboratory tests revealed blood gas analysis&#58; pH 7&#46;392&#44; pCO<span class="elsevierStyleInf">2</span> 32 mmHg&#44; pO<span class="elsevierStyleInf">2</span> 101 mmHg&#44; lactate 3&#46;5 mmol&#47;l&#44; HCO<span class="elsevierStyleInf">3</span> 20&#46;8 mmol&#47;l&#59; COHb 29&#46;2&#37;&#59; serial troponin I 1&#46;21&#8594;5&#46;25&#8594;6&#46;13&#8594;3&#46;65 &#956;g&#47;l&#59; myoglobin 1378&#8594;964&#8594;352 &#956;g&#47;l&#59; and NT-proBNP 1330 pg&#47;l&#46; The electrocardiogram showed sinus rhythm&#44; heart rate 110 bpm&#44; and ST-segment depression of 2 mm in V4 and 1 mm in V5&#46; Transthoracic echocardiography revealed a left ventricle with normal wall motion and preserved ejection fraction&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Given the clinical and epidemiological context&#44; myocardial and central nervous system ischemia due to prolonged CO exposure was assumed and normobaric oxygen therapy was immediately started&#46; In view of evidence of injury to two major organ systems the indication for hyperbaric oxygen therapy was discussed with a specialist colleague&#44; who suggested maintaining conservative treatment with oxygen therapy and in-hospital monitoring for 72 h&#46; The patient was discharged on the third day and was still asymptomatic at 400 days of follow-up&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Besides symptoms and signs of central nervous system dysfunction&#44; myocardial damage should also always be considered in the context of CO poisoning&#46; Hyperbaric therapy is still controversial and the lack of objective data highlights the need for new randomized studies&#46;</p></span>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A intoxica&#231;&#227;o por mon&#243;xido de carbono &#40;MC&#41; &#233; um dos tipos de intoxica&#231;&#227;o mais frequente e a principal causa de morte por intoxica&#231;&#227;o no mundo&#46; A les&#227;o card&#237;aca provocada pela intoxica&#231;&#227;o por MC tem sido pouco descrita apesar de ser um fator preditor de mau progn&#243;stico&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Apresentamos o caso de uma mulher de 24 anos&#44; saud&#225;vel&#44; que recorre ao servi&#231;o de urg&#234;ncia por lipotimia sem perda de conhecimento&#46; Referia cefaleia holocraniana associada a n&#225;useas e v&#243;mitos com duas semanas de evolu&#231;&#227;o&#46; Analiticamente&#58; gasimetria pH 7&#44;392&#59; pCO<span class="elsevierStyleInf">2</span> 32 mmHg&#44; pO<span class="elsevierStyleInf">2</span> 101 mmHg&#44; lactatos 3&#44;5 mmol&#47;L&#44; HCO<span class="elsevierStyleInf">3</span> 20&#44;8 mmol&#47;L&#44; COHb 29&#44;2&#37;&#59; troponina I seriada 1&#44;21&#8594;5&#44;25&#8594;6&#44;13&#8594;3&#44;65 ug&#47;L&#44; mioglobina 1378&#8594;964&#8594;352 ug&#47;L&#44; NT-ProBNP 1330 pg&#47;L&#46; Eletrocardiograma&#58; ritmo sinusal&#44; frequ&#234;ncia card&#237;aca 110 bpm&#44; depress&#227;o do segmento ST de 2 mm em V4 e 1 mm em V5&#46; Ecocardiograma transtor&#225;cico&#58; ventr&#237;culo esquerdo sem altera&#231;&#245;es da cin&#233;tica segmentar e boa fun&#231;&#227;o sist&#243;lica global&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Associando-se a cl&#237;nica ao contexto epidemiol&#243;gico assumiu-se isquemia do mioc&#225;rdio e do sistema nervoso central por exposi&#231;&#227;o prolongada ao MC&#46; Iniciou-se prontamente oxigenoterapia normob&#225;rica&#46; Perante a evid&#234;ncia de compromisso de dois &#243;rg&#227;os nobres&#44; foi discutida com o colega especialista nesta &#225;rea a indica&#231;&#227;o para tratamento com oxig&#233;nio hiperb&#225;rico&#44; sugeriu manter tratamento conservador com oxigenoterapia e vigil&#226;ncia em internamento durante 72 h&#46; Teve alta ao terceiro dia e mant&#233;m-se assintom&#225;tica aos 400 dias de follow-up&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Tal como os sintomas e sinais de disfun&#231;&#227;o do sistema nervoso central&#44; a les&#227;o do mioc&#225;rdio deve ser sistematicamente equacionada no contexto de intoxica&#231;&#227;o por MC&#46; A indica&#231;&#227;o para terap&#234;utica em c&#226;mara hiperb&#225;rica permanece controversa e com indica&#231;&#245;es pouco objetivas&#44; a apelar a novos estudos aleatorizados&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Cardiga R&#44; Proen&#231;a M&#44; Carvalho C&#44; et al&#46; Intoxica&#231;&#227;o por mon&#243;xido de carbono com compromisso card&#237;aco&#58; o que sabemos&#63; Rev Port Cardiol&#46; 2015&#59;34&#58;557&#46;e1&#8211;557&#46;e5&#46;</p>"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 874
            "Ancho" => 1500
            "Tamanyo" => 181900
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Electrocardiogram on admission to the emergency room&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 874
            "Ancho" => 1500
            "Tamanyo" => 178975
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Electrocardiogram 15 h after admission to the emergency room&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">D1&#58; one day after event&#59; D2&#58; two days after event&#59; D3&#58; three days after event&#59; H0&#58; at emergency room admission&#59; H6&#58; 6 h after event&#59; H9&#58; 9 h after event&#59; H20&#58; 20 h after event&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">H0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">H6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">H9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">H20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">D1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">D2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">D3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hemoglobin &#40;g&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Leukocytes &#40;&#215;10<span class="elsevierStyleSup">9</span>&#47;l&#41;&#47;neutrophils &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&#46;8&#47;93&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#46;6&#47;13&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;1&#47;47&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#46;8&#47;5&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">C-reactive protein &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Creatininemia &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Troponinemia &#40;&#956;g&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Creatine kinase &#40;U&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2164&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3058&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">791&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Myoglobinemia &#40;&#956;g&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1378&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">964&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">352&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">NT-proBNP &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1330&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">384&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab891420.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Changes in laboratory values during hospital stay&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0030"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Loss of consciousness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Neurological deficits&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Ischemic cardiac changes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Metabolic acidosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Carboxyhemoglobin &#62;25&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab891421.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Indications for hyperbaric oxygen therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">12</span></a></p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:14 [
            0 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carbon monoxide intoxication&#58; an updated review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;D&#46; Prockop"
                            1 => "R&#46;I&#46; Chichkova"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jns.2007.06.037"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Sci"
                        "fecha" => "2007"
                        "volumen" => "262"
                        "paginaInicial" => "122"
                        "paginaFinal" => "130"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17720201"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Unintentional carbon monoxide-related deaths in the United States&#44; 1979 through 1988"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46; Cobb"
                            1 => "R&#46;A&#46; Etzel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1991"
                        "volumen" => "266"
                        "paginaInicial" => "659"
                        "paginaFinal" => "663"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1712865"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trends in the incidence of carbon monoxide poisoning in the United States"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "N&#46;B&#46; Hampson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajem.2005.03.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Emerg Med"
                        "fecha" => "2005"
                        "volumen" => "23"
                        "paginaInicial" => "838"
                        "paginaFinal" => "841"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16291437"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Internamentos por intoxica&#231;&#227;o com mon&#243;xido de carbono em Portugal"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;C&#46; S&#225;"
                            1 => "R&#46;P&#46; Rodrigues"
                            2 => "R&#46; Moura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Med Port"
                        "fecha" => "2011"
                        "volumen" => "24"
                        "paginaInicial" => "727"
                        "paginaFinal" => "734"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22525624"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Myocardial toxicity from carbon monoxide poisoning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;F&#46; Anderson"
                            1 => "D&#46;C&#46; Allensworth"
                            2 => "W&#46;J&#46; de Groot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1967"
                        "volumen" => "67"
                        "paginaInicial" => "1172"
                        "paginaFinal" => "1182"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6061932"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The electrocardiographic changes found in 22 cases of carbon monoxide poisoning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46;H&#46; Stearns"
                            1 => "C&#46;K&#46; Drinker"
                            2 => "T&#46;J&#46; Shaughnessy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1938"
                        "volumen" => "15"
                        "paginaInicial" => "434"
                        "paginaFinal" => "447"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mitochondrial cytochrome c oxidase inhibition during acute carbon monoxide poisoning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "O&#46; Miro"
                            1 => "J&#46; Casademont"
                            2 => "A&#46; Barrientos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacol Toxicol"
                        "fecha" => "1998"
                        "volumen" => "82"
                        "paginaInicial" => "199"
                        "paginaFinal" => "202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9584335"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carbon monoxide poisoning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Ernst"
                            1 => "J&#46;D&#46; Zibrak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199811263392206"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1998"
                        "volumen" => "339"
                        "paginaInicial" => "1603"
                        "paginaFinal" => "1608"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9828249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Dor como 5&#176; Sinal Vital&#44; Registo Sistem&#225;tico da Intensidade da Dor&#59; Dire&#231;&#227;o Geral da Sa&#250;de 2011&#46;"
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Intoxica&#231;&#227;o&#58; Mais de 100 pessoas morreram nos &#250;ltimos seis anos&#46; Correio da Manh&#227;&#44; January 31&#44; 2012&#46;"
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk factors for short-term mortality from carbon monoxide poisoning treated with hyperbaric oxygen"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46;B&#46; Hampson"
                            1 => "N&#46;M&#46; Hauff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/CCM.0b013e31818419d8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "2008"
                        "volumen" => "36"
                        "paginaInicial" => "2523"
                        "paginaFinal" => "2527"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18679118"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Practice recommendations in the diagnosis&#44; management&#44; and prevention of carbon monoxide poisoning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "N&#46;B&#46; Hampson"
                            1 => "C&#46;A&#46; Piantadosi"
                            2 => "S&#46;R&#46; Thom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201207-1284CI"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2012"
                        "volumen" => "186"
                        "paginaInicial" => "1095"
                        "paginaFinal" => "1101"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23087025"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular manifestations of moderate to severe carbon monoxide poisoning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46; Satran"
                            1 => "C&#46;R&#46; Henry"
                            2 => "C&#46; Adkinson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "JACC"
                        "fecha" => "2005"
                        "volumen" => "5"
                        "paginaInicial" => "1513"
                        "paginaFinal" => "1516"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Myocardial injury and long-term mortality following moderate to severe carbon monoxide poisoning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;R&#46; Henry"
                            1 => "D&#46; Satran"
                            2 => "B&#46; Lindgren"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.295.4.398"
                      "Revista" => array:5 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2006"
                        "volumen" => "295"
                        "paginaInicial" => "398"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16434630"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21742049/0000003400000009/v1_201509130054/S2174204915001567/v1_201509130054/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9914"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case report"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21742049/0000003400000009/v1_201509130054/S2174204915001567/v1_201509130054/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001567?idApp=UINPBA00004E"
]
Article information
ISSN: 21742049
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 7 3 10
2024 October 104 33 137
2024 September 88 18 106
2024 August 82 32 114
2024 July 48 31 79
2024 June 38 21 59
2024 May 67 27 94
2024 April 59 29 88
2024 March 44 30 74
2024 February 69 38 107
2024 January 75 25 100
2023 December 59 31 90
2023 November 53 28 81
2023 October 69 27 96
2023 September 60 19 79
2023 August 57 16 73
2023 July 73 8 81
2023 June 50 15 65
2023 May 79 31 110
2023 April 47 10 57
2023 March 70 30 100
2023 February 62 23 85
2023 January 81 18 99
2022 December 78 25 103
2022 November 76 28 104
2022 October 63 20 83
2022 September 85 30 115
2022 August 80 40 120
2022 July 110 31 141
2022 June 78 29 107
2022 May 84 40 124
2022 April 69 23 92
2022 March 51 45 96
2022 February 46 30 76
2022 January 58 44 102
2021 December 58 36 94
2021 November 64 32 96
2021 October 60 46 106
2021 September 50 33 83
2021 August 62 37 99
2021 July 38 41 79
2021 June 48 26 74
2021 May 52 77 129
2021 April 83 45 128
2021 March 106 19 125
2021 February 109 26 135
2021 January 67 15 82
2020 December 82 11 93
2020 November 75 33 108
2020 October 79 14 93
2020 September 72 18 90
2020 August 42 7 49
2020 July 75 2 77
2020 June 70 19 89
2020 May 77 15 92
2020 April 92 21 113
2020 March 80 13 93
2020 February 120 40 160
2020 January 87 11 98
2019 December 67 6 73
2019 November 72 13 85
2019 October 46 7 53
2019 September 80 10 90
2019 August 45 6 51
2019 July 59 18 77
2019 June 48 5 53
2019 May 39 12 51
2019 April 26 17 43
2019 March 30 9 39
2019 February 16 7 23
2019 January 34 6 40
2018 December 28 10 38
2018 November 90 10 100
2018 October 212 16 228
2018 September 69 12 81
2018 August 59 9 68
2018 July 31 5 36
2018 June 18 9 27
2018 May 48 9 57
2018 April 40 4 44
2018 March 33 7 40
2018 February 32 1 33
2018 January 43 9 52
2017 December 46 7 53
2017 November 53 14 67
2017 October 39 23 62
2017 September 28 12 40
2017 August 34 12 46
2017 July 29 11 40
2017 June 27 22 49
2017 May 47 7 54
2017 April 19 4 23
2017 March 41 58 99
2017 February 37 6 43
2017 January 42 9 51
2016 December 31 13 44
2016 November 51 5 56
2016 October 39 7 46
2016 September 50 5 55
2016 August 15 4 19
2016 July 22 8 30
2016 June 20 11 31
2016 May 13 5 18
2016 April 45 1 46
2016 March 39 19 58
2016 February 65 29 94
2016 January 54 23 77
2015 December 61 20 81
2015 November 66 28 94
2015 October 116 59 175
2015 September 166 75 241
Show all

Follow this link to access the full text of the article

Idiomas
Revista Portuguesa de Cardiologia (English edition)
en pt

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

By checking that you are a health professional, you are stating that you are aware and accept that the Portuguese Journal of Cardiology (RPC) is the Data Controller that processes the personal information of users of its website, with its registered office at Campo Grande, n.º 28, 13.º, 1700-093 Lisbon, telephone 217 970 685 and 217 817 630, fax 217 931 095, and email revista@spc.pt. I declare for all purposes that the information provided herein is accurate and correct.