Original Article
Analysis of lipid-lowering therapy and factors affecting regularity of statin intake in patients with cardiovascular disease enrolled in the PROFILE registry
Análise da terapêutica de redução lipídica e dos fatores que afetam a regularidade da toma de estatinas em doentes com doenças cardiovasculares inseridos no Registo Profile
a FGBI “National Research Centre of Preventive Medicine” of the Ministry of Healthcare of the Russian Federation, Moscow, Russia
b FGBI “Joint Hospital and Polyclinic” Department of Presidential Affairs of the Russian Federation, Moscow, Russia
c IM. Sechenov First Moscow State Medical University, Moscow, Russia
Read
6395
Timeswas read the article
1724
Total PDF
4671
Total HTML
Share statistics
array:24 [ "pii" => "S217420491500032X" "issn" => "21742049" "doi" => "10.1016/j.repce.2014.08.020" "estado" => "S300" "fechaPublicacion" => "2015-02-01" "aid" => "586" "copyright" => "Sociedade Portuguesa de Cardiologia" "copyrightAnyo" => "2014" "documento" => "article" "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2015;34:111-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3694 "formatos" => array:3 [ "EPUB" => 184 "HTML" => 2869 "PDF" => 641 ] ] "Traduccion" => array:1 [ "en" => array:19 [ "pii" => "S0870255115000062" "issn" => "08702551" "doi" => "10.1016/j.repc.2014.08.021" "estado" => "S300" "fechaPublicacion" => "2015-02-01" "aid" => "586" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2015;34:111-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3365 "formatos" => array:3 [ "EPUB" => 207 "HTML" => 2395 "PDF" => 763 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Analysis of lipid-lowering therapy and factors affecting regularity of statin intake in patients with cardiovascular disease enrolled in the PROFILE registry" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "111" "paginaFinal" => "116" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Análise da terapêutica de redução lipídica e dos fatores que afetam a regularidade da toma de estatinas em doentes com doenças cardiovasculares inseridos no Registo Profile" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1601 "Ancho" => 1587 "Tamanyo" => 104430 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Differences between groups by LDL level. 1: taking statins regularly; 2 not taking statins; 3: taking statins irregularly.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Oleg Gaisenok, Sergey Martsevich, Svetlana Tripkosh, Yulia Lukina" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Oleg" "apellidos" => "Gaisenok" ] 1 => array:2 [ "nombre" => "Sergey" "apellidos" => "Martsevich" ] 2 => array:2 [ "nombre" => "Svetlana" "apellidos" => "Tripkosh" ] 3 => array:2 [ "nombre" => "Yulia" "apellidos" => "Lukina" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S217420491500032X" "doi" => "10.1016/j.repce.2014.08.020" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217420491500032X?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115000062?idApp=UINPBA00004E" "url" => "/08702551/0000003400000002/v3_201706020139/S0870255115000062/v3_201706020139/en/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2174204915000331" "issn" => "21742049" "doi" => "10.1016/j.repce.2014.08.021" "estado" => "S300" "fechaPublicacion" => "2015-02-01" "aid" => "587" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2015;34:117-23" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2979 "formatos" => array:3 [ "EPUB" => 181 "HTML" => 2272 "PDF" => 526 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Musculoskeletal complaints in cardiac rehabilitation: Prevalence and impact on cardiovascular risk factor profile and functional and psychosocial status" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "117" "paginaFinal" => "123" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Dor músculo-esquelética em reabilitação cardíaca: prevalência e impacto no perfil de risco cardiovascular e estado funcional e psicossocial" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "José Afonso Rocha, Thomas G. Allison, José Miguel Santoalha, Vítor Araújo, Fernando Parada Pereira, Maria Júlia Maciel" "autores" => array:6 [ 0 => array:2 [ "nombre" => "José Afonso" "apellidos" => "Rocha" ] 1 => array:2 [ "nombre" => "Thomas G." "apellidos" => "Allison" ] 2 => array:2 [ "nombre" => "José Miguel" "apellidos" => "Santoalha" ] 3 => array:2 [ "nombre" => "Vítor" "apellidos" => "Araújo" ] 4 => array:2 [ "nombre" => "Fernando" "apellidos" => "Parada Pereira" ] 5 => array:2 [ "nombre" => "Maria Júlia" "apellidos" => "Maciel" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0870255115000074" "doi" => "10.1016/j.repc.2014.08.022" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115000074?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915000331?idApp=UINPBA00004E" "url" => "/21742049/0000003400000002/v2_201502270337/S2174204915000331/v2_201502270337/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2174204915000318" "issn" => "21742049" "doi" => "10.1016/j.repce.2014.08.019" "estado" => "S300" "fechaPublicacion" => "2015-02-01" "aid" => "585" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2015;34:103-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4306 "formatos" => array:3 [ "EPUB" => 214 "HTML" => 3350 "PDF" => 742 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Prevalence of dyslipidemia in adolescents: Comparison between definitions" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "103" "paginaFinal" => "109" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Prevalência de dislipidemias em adolescentes: comparação entre diferentes critérios" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2024 "Ancho" => 1638 "Tamanyo" => 136954 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Prevalence of dyslipidemia subclassifications in male (A) (n=423) and female (B) (n=577) adolescents, according to the three diagnostic definitions. HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TC: total cholesterol; TG: triglycerides. * p<0.05 (BSC≠NCEP≠NHANES); † p<0.05 (BSC=NCEP>NHANES); ‡ p<0.05 (BSC>NCEP=NHANES).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Crisieli M. Tomeleri, Enio R.V. Ronque, Danilo R.P. Silva, Crivaldo G. Cardoso Júnior, Rômulo A. Fernandes, Denilson C. Teixeira, Décio S. Barbosa, Danielle Venturini, Alessandra M. Okino, Jair A. Oliveira, Edilson S. Cyrino" "autores" => array:11 [ 0 => array:2 [ "nombre" => "Crisieli M." "apellidos" => "Tomeleri" ] 1 => array:2 [ "nombre" => "Enio R.V." "apellidos" => "Ronque" ] 2 => array:2 [ "nombre" => "Danilo R.P." "apellidos" => "Silva" ] 3 => array:2 [ "nombre" => "Crivaldo G." "apellidos" => "Cardoso Júnior" ] 4 => array:2 [ "nombre" => "Rômulo A." "apellidos" => "Fernandes" ] 5 => array:2 [ "nombre" => "Denilson C." "apellidos" => "Teixeira" ] 6 => array:2 [ "nombre" => "Décio S." "apellidos" => "Barbosa" ] 7 => array:2 [ "nombre" => "Danielle" "apellidos" => "Venturini" ] 8 => array:2 [ "nombre" => "Alessandra M." "apellidos" => "Okino" ] 9 => array:2 [ "nombre" => "Jair A." "apellidos" => "Oliveira" ] 10 => array:2 [ "nombre" => "Edilson S." "apellidos" => "Cyrino" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0870255115000050" "doi" => "10.1016/j.repc.2014.08.020" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115000050?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915000318?idApp=UINPBA00004E" "url" => "/21742049/0000003400000002/v2_201502270337/S2174204915000318/v2_201502270337/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Analysis of lipid-lowering therapy and factors affecting regularity of statin intake in patients with cardiovascular disease enrolled in the PROFILE registry" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "111" "paginaFinal" => "116" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Oleg Gaisenok, Sergey Martsevich, Svetlana Tripkosh, Yulia Lukina" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Oleg" "apellidos" => "Gaisenok" "email" => array:1 [ 0 => "ogaisenok@gnicpm.ru" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Sergey" "apellidos" => "Martsevich" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "Svetlana" "apellidos" => "Tripkosh" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Yulia" "apellidos" => "Lukina" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "FGBI “National Research Centre of Preventive Medicine” of the Ministry of Healthcare of the Russian Federation, Moscow, Russia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "FGBI “Joint Hospital and Polyclinic” Department of Presidential Affairs of the Russian Federation, Moscow, Russia" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "IM. Sechenov First Moscow State Medical University, Moscow, Russia" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Análise da terapêutica de redução lipídica e dos fatores que afetam a regularidade da toma de estatinas em doentes com doenças cardiovasculares inseridos no Registo Profile" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1593 "Ancho" => 1578 "Tamanyo" => 149939 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Differences between groups by LDL level. 1: taking statins regularly; 2 not taking statins; 3: taking statins irregularly.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The value of statins to achieve target levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides is emphasized in current international guidelines.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> The relationship between LDL level and frequency of cardiovascular events has been confirmed in large studies.<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">2–7</span></a> However, clinicians do not always follow the recommendations.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">8</span></a> The situation with regard to the use of lipid-lowering drugs in Russia is particularly difficult. A study of statin use in Moscow obtained the following results: only 30% of patients with coronary heart disease (CHD) took statins; 80% of prescriptions were for simvastatin or lovastatin at initial doses; and mean duration of treatment was five months.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">9</span></a> However, this study investigated selective samples of patients. Data that are more relevant to clinical practice are obtained from studies conducted using the principles of consistent inclusion of patients, i.e. under registry rules.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">10</span></a> Analysis of the drugs taken as outpatients by high-risk patients before a reference myocardial infarction in the LIS study enrolled in the hospital's registry showed that the frequency of statin use was only 2%.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">11</span></a> With modern cardiovascular disease registries it is possible not only to determine the frequency of drug prescriptions but also to assess the factors that influence compliance with medication.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Objective</span><p id="par0010" class="elsevierStylePara elsevierViewall">The aim of this study was to analyze the quality of lipid-lowering therapy in a cohort of patients with cardiovascular disease enrolled in a Moscow-based registry, and to analyze the factors affecting the regularity of statin administration in this patient category.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">The PROFILE registry is a outpatient registry compiled by the Preventive Pharmacotherapy Department of the National Research Center for Preventive Medicine (NRCPM) of the Ministry of Healthcare of the Russian Federation. NRCPM is a federal medical center to which patients from other medical institutions (including municipal) are referred to seek medical advice. The PROFILE registry includes all patients presenting to the department for consultations on cardiovascular disease.</p><p id="par0020" class="elsevierStylePara elsevierViewall">This study included all patients who sought medical advice in the Preventive Pharmacotherapy Department between May 1 and December 31, 2011. Each patient was given a specially designed questionnaire in order to assess compliance with the prescribed treatment. Patients were required to answer the following questions: (1) if they knew, according to the results of previous exams, that they had elevated cholesterol levels (yes, no, don’t know); (2) what method of hypercholesterolemia correction they used (diet, medication, physical exercise, or other); (3) if they were taking any statins (regularly, no, irregularly); and (4) if yes, what statin preparation and what dose they were taking. Compliance with statin therapy was assessed on the basis of the responses received and the regularity of statin intake. A registration card was completed for each patient observed during this period. The questionnaire and the registration card were developed by the researchers. The questionnaire was filled in directly by the patient, while the registration card (including anthropometric, clinical, laboratory and test data, and previous history) was filled in by a physician.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Patients were divided into three age groups: <50 years old, 50–70 years old, and >70 years old. In addition, the following factors were taken into account: (a) alcohol consumption (according to the questionnaire data) – none, occasional (once or twice a week or less), regularly (three or more times a week); (b) smoking status: current smoker, non-smoker, former smoker; (c) education: higher education or not; (d) statin dose: low (rosuvastatin <10 mg, atorvastatin <20 mg, simvastatin <20 mg), medium/standard (rosuvastatin 10–20 mg, atorvastatin 20–40 mg, simvastatin 20–40 mg), high (rosuvastatin >20 mg; atorvastatin >40 mg; simvastatin >40 mg). On the basis of these data patients’ compliance with treatment and its effectiveness as shown by the results of further analysis were assessed.</p><p id="par0030" class="elsevierStylePara elsevierViewall">All patients gave their written informed consent for participation in the study and the questionnaire was approved by the Independent Ethics Committee of NRCPM. Blood tests for cholesterol and its fractions were performed in the laboratory of NRCPM on the day of each patient's enrollment.</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Statistical analysis</span><p id="par0035" class="elsevierStylePara elsevierViewall">The statistical data processing was performed using the Statistica 6.0 software package (StatSoft). Data on the three groups are presented as median and interquartile range or as number and percentage of the total. The chi-square test was used to compare groups for qualitative variables. Rank analysis of variance using the Kruskal-Wallis test was used for multiple comparisons of quantitative variables between groups (three or more). Calculation of odds ratios (OR) and 95% confidence intervals (CI) was carried out to determine the influence of various factors on regularity of statin intake in patients with cardiovascular disease. OR were calculated on the basis of 2×2 contingency tables, in cells which accounted for the number of patients regularly and irregularly taking statins depending on the basic attributes analyzed. Differences were considered statistically significant when p<0.05.</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0040" class="elsevierStylePara elsevierViewall">The present study included consecutive patients seen in the Preventive Pharmacotherapy Department between May 1 and December 31, 2011. During this period 274 patients were recorded in the registry. Their main demographic and clinical characteristics are presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Patients were divided into three groups according to how regularly they were taking statins: regularly, irregularly, or none. These groups were compared in terms of lipid profile (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">There were significant differences in total cholesterol and LDL cholesterol levels between patients regularly taking statins and patients not taking or irregularly taking statins (<a class="elsevierStyleCrossRefs" href="#fig0005">Figures 1 and 2</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">Odds ratios (OR) and their 95% confidence intervals (CI) were calculated to determine the influence of various factors on regularity of statin intake (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>).</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion and Conclusions</span><p id="par0065" class="elsevierStylePara elsevierViewall">The question of patients’ compliance with prescribed therapy is extremely important, especially concerning statins, given their possible side effects that require dynamic control by biochemical blood tests.</p><p id="par0070" class="elsevierStylePara elsevierViewall">This study addresses these issues. Certain limitations should be noted, particularly the selectivity of the study population; this was not an epidemiological study, but an analysis of clinical practice that assessed ordinary patients.</p><p id="par0075" class="elsevierStylePara elsevierViewall">The criteria for statin use in this study were based on current guidelines: patients with TC >5 mmol/l and LDL >3 mmol/l and high-risk patients with documented CHD, previous MI or stroke or associated clinical conditions, as well as with additional risk factors including TC >4.5 mmol/l and LDL >2.5 mmol/l.</p><p id="par0110" class="elsevierStylePara elsevierViewall">The study is relevant to the issue, which has also been analyzed in other studies carried out in recent years.<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">12–16</span></a> It is striking that our study, which was small but governed strictly by guidelines for registries, revealed such interesting data. In our analysis of the factors affecting regularity of statin intake in patients with cardiovascular disease enrolled in the PROFILE registry, those that were most likely to increase the chances that the patient would take statins regularly were the presence of CHD and a history of MI and PCI (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). At the same time it should be noted that a history of stroke and the presence of diabetes did not motivate these patients to take statins on a regular basis.</p><p id="par0085" class="elsevierStylePara elsevierViewall">This can probably be explained by the fact that cardiologists are more likely to adhere to current international guidelines for the management of their patients and to prescribe statins, in contrast to neurologists and endocrinologists, who also often see patients with a history of stroke and diabetes, respectively.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Ethical disclosures</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Protection of human and animal subjects</span><p id="par0090" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Confidentiality of data</span><p id="par0095" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Right to privacy and informed consent</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document.</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflicts of interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres439414" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec462603" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres439413" "titulo" => "Resumo" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusões" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec462602" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Objective" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Methods" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Statistical analysis" ] ] ] 7 => array:2 [ "identificador" => "sec0025" "titulo" => "Results" ] 8 => array:2 [ "identificador" => "sec0030" "titulo" => "Discussion and Conclusions" ] 9 => array:3 [ "identificador" => "sec0035" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0040" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0045" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0050" "titulo" => "Right to privacy and informed consent" ] ] ] 10 => array:2 [ "identificador" => "sec0055" "titulo" => "Conflicts of interest" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-06-05" "fechaAceptado" => "2014-08-16" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec462603" "palabras" => array:4 [ 0 => "Lipid-lowering therapy" 1 => "Statins" 2 => "Compliance" 3 => "Registry" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec462602" "palabras" => array:4 [ 0 => "Terapêutica de redução de lípidos" 1 => "Estatinas" 2 => "Adesão terapêutica" 3 => "Registo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to analyze the quality of lipid-lowering therapy in a cohort of patients with cardiovascular disease enrolled in a Moscow-based registry, and to analyze the factors affecting the regularity of statin administration in this patient category.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The present study included all patients who successively sought medical advice in the Preventive Pharmacotherapy Department of the Ministry of Healthcare of the Russian Federation between May 1 and December 31, 2011 (n=274). Each patient was given a specially designed questionnaire in order to assess compliance with the prescribed treatment that included the following questions: (1) if they knew, according to the results of previous exams, that they had elevated cholesterol levels (yes, no, don’t know); (2) what method of hypercholesterolemia correction they used (diet, medication, physical exercise, or other); (3) if they were taking any statins (regularly, no, irregularly); and (4) if yes, what statin preparation and what dose they were taking. Patients’ compliance with statin therapy was assessed on the basis of the responses received and the regularity of statin intake.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The influence of various factors on regularity of statin intake in patients with cardiovascular disease was assessed by calculating odds ratios (OR) and 95% confidence intervals (CI) for advanced age (>70 years) (OR 0.49); higher statin dose than standard (OR 0.49); hypertension (OR 1.659); history of acute cerebrovascular event (OR 2.019); diabetes (OR 1.023); coronary heart disease (CHD) (OR 4.357); history of myocardial infarction (MI) (OR 4.838); history of coronary angiography/percutaneous coronary intervention (PCI) (OR 5.167).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Analysis of factors with impact on regular compliance with statin therapy showed that the following were most significant: CHD, history of MI, and history of PCI. Previous cerebrovascular events and presence of diabetes did not motivate these patients to take statins on a regular basis.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "pt" => array:3 [ "titulo" => "Resumo" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">O objetivo deste estudo foi analisar a qualidade do tratamento hipolipemiante realizado numa coorte de pacientes portadores de doenças cardiovasculares, obtido sob a forma de registo, em Moscovo, e analisar os fatores que afetam a regularidade da administração de estatinas nesta categoria de pacientes.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">O presente estudo incluiu todos os pacientes que consecutivamente procuraram aconselhamento médico no Departamento de Farmacoterapia Preventiva durante o período de 1 de maio a 31 de dezembro 2011 (n=274). Cada paciente recebeu um questionário especialmente concebido para avaliar a adesão dos pacientes ao tratamento realizado, que incluiu as seguintes questões: 1) se tem conhecimento de níveis elevados de colesterol, de acordo com os exames realizados previamente (sim, não, desconhece); 2) que método utiliza para correção da hipercolesterolemia (dieta, medicação, exercício físico, outro); 3) se toma estatinas (toma regularmente, não toma, toma irregularmente); 4) se sim, qual a estatina e a dose. Com base nas resposta recebidas e regularidade da toma de estatinas, foi efetuada a avaliação do conceito de adesão à terapêutica com estes fármacos.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Para determinar o significado de uma série de fatores de acordo com a sua influência sobre a regularidade da ingestão de estatinas em pacientes com doenças cardiovasculares, foram calculados <span class="elsevierStyleItalic">odds ratio</span> (OR): idade avançada (>70anos) - OR de 0,49; aumento da dose de estatina – OR de 0,49; hipertensão arterial (HA) - OR de 1,65; história prévia de doença cerebrovascular aguda (ACVD)- OR de 2,01; diabetes <span class="elsevierStyleItalic">mellitus</span> (DM)- OR de 1,02; doença arterial coronária (DAC)- OR de 4,35; história prévia de enfarte do miocárdio (IM) – OR de 4,83; antecedenetes de angiografia coronária (CAG)/intervenção coronária percutânea (ICP) OR de 5,16.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusões</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A análise dos fatores com maior impacto sobre a adesão à toma regular de estatinas mostrou serem mais significativos os seguintes: CHD, história prévia de MI e de PCI. Concomitantemente, salienta-se que a história prévia de ACVD e a presença de DM não motivaram estas classes de doentes a tomar estatinas de forma regular.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusões" ] ] ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1587 "Ancho" => 1575 "Tamanyo" => 150850 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Differences between groups by total cholesterol level. 1: taking statins regularly; 2 not taking statins; 3: taking statins irregularly.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1593 "Ancho" => 1578 "Tamanyo" => 149939 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Differences between groups by LDL level. 1: taking statins regularly; 2 not taking statins; 3: taking statins irregularly.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">BMI: body mass index; CABG: coronary artery bypass grafting; CAG: coronary angiography; CHD: coronary heart disease; HC: hypercholesterolemia; MI: myocardial infarction; PCI: percutaneous coronary intervention.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Age, years (range)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">64.0 (57.0–72.0) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Male gender</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">135 (49.3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Higher education</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">231 (84.3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Currently employed</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">141 (51.4%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">BMI</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28.7 (25.4–31.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Smoking</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40 (14.6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Baseline HC >5.0 mmol/l</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">266 (97.0%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Current HC >5.0 mmol/l</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">113 (41.2%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Current HC >4.5 mmol/l</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">153 (55.8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Diabetes</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">43 (15.7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Hypertension</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">230 (83.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">CHD</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">85 (31.0%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Angina CCS grade I-IV</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">66 (24.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">History of MI</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">47 (17.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Interventional procedures</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>CAG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50 (18.2%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PCI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 (8.0%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>CABG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (3.3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">History of stroke</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 (6.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Heart failure</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50 (18.2%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab685927.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Main demographic and clinical characteristics of the study population.</p>" ] ] 3 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">HDL: high-density lipoprotein cholesterol; LDL: low-density lipoprotein cholesterol; P25: 25th percentile; P75: 75th percentile; TC: total cholesterol; TG: triglycerides; VLDL: very low density lipoprotein cholesterol.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Taking statins regularly</th><th class="td" title="table-head " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Not taking statins</th><th class="td" title="table-head " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Taking statins irregularly</th><th class="td" title="table-head " align="left" valign="top" scope="col">p \t\t\t\t\t\t\n \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Median \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P25 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P75 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Median \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P25 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P75 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Median \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P25 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P75 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">TC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.80 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">LDL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.89 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">VLDL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.6456 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">HDL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.95 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.95 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.8905 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">TG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.65 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.65 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.97 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.5421 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab685928.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Comparisons between groups according to lipid profile.</p>" ] ] 4 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">CAG: coronary angiography; CHD: coronary heart disease; CI: confidence interval; PCI: percutaneous coronary intervention.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">95% CI \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Sociodemographic variables</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Elderly age (>70 years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.429 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.224–0.822 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.015 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Higher statin dose than standard \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.169–1.423 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.306 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Smoking \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.607 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.812–1.404 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.342 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Education \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.855 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.384–1.906 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.86 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Avoidance of alcohol \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.145 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.640–2.049 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.757 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Male gender \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.775 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.993–3.173 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.072 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Currently employed \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.966 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.694–4.322 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.129 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Clinical variables</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Diabetes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.023 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.489–2.138 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.898 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hypertension \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.659 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.692–3.979 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.365 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>History of stroke \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.019 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.631–6.463 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.347 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>CHD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.357 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.188–8.677 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>History of MI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.838 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.765–13.259 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>History of CAG/PCI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.167 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.055–12.99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab685926.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Influence of major factors on regularity of statin intake.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib0085" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "ESC/EAS Guidelines for the management of dyslipidaemias" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehr158" "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2011" "volumen" => "32" "paginaInicial" => "1769" "paginaFinal" => "1818" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21712404" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0090" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "LongTerm Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Eng J Med" "fecha" => "1998" "volumen" => "339" "paginaInicial" => "1349" "paginaFinal" => "1357" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0095" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduction of stroke incidence after myocardial infarction with pravastatin: the Cholesterol and Recurrent Events (CARE) study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.F. Plehn" 1 => "B.R. Davis" 2 => "F.M. Sacks" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1999" "volumen" => "99" "paginaInicial" => "216" "paginaFinal" => "223" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9892586" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0100" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Heart Protection Study Collaborative Group" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(02)09327-3" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2002" "volumen" => "360" "paginaInicial" => "7" "paginaFinal" => "22" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12114036" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0105" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "West of Scotland Coronary Prevention Study: identification of high-risk groups and comparison with other cardiovascular intervention trials" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "West of Scotland Coronary Prevention Group" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1996" "volumen" => "348" "paginaInicial" => "1339" "paginaFinal" => "1342" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8918276" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0110" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "for the AFCAPS/TexCAPS Research Group" "etal" => true "autores" => array:3 [ 0 => "J.R. Downs" 1 => "M. Clearfield" 2 => "S. Weis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1998" "volumen" => "279" "paginaInicial" => "1615" "paginaFinal" => "1622" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9613910" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0115" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P.S. Sever" 1 => "B. Dahlof" 2 => "N.R. Poulter" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(03)12948-0" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2003" "volumen" => "361" "paginaInicial" => "1149" "paginaFinal" => "1158" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12686036" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0120" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Yusuf" 1 => "S. Islam" 2 => "C.K. Chow" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(11)61215-4" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2011" "volumen" => "378" "paginaInicial" => "1231" "paginaFinal" => "1243" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21872920" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0125" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Main results of the Moscow Research on Statines (to Moscow Statin Survey, MSS)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.V. Susekov" 1 => "M.Yu. Zubareva" 2 => "A.D. Deev" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Serdce" "fecha" => "2006" "paginaInicial" => "324" "paginaFinal" => "328" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0130" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Using registers to study effectiveness and safety of drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.Yu. Martsevich" 1 => "L.Yu. Drozdova" 2 => "N.P. Kutishenko" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clinician" "fecha" => "2012" "volumen" => "3–4" "paginaInicial" => "4" "paginaFinal" => "9" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0135" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The LIS study (Lubertsy study of mortality in patients with acute myocardial infarction). Evaluation of pharmacotherapy. Part 1. Treatment of patients before myocardial infarction and its influence on hospital mortality" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.Yu. Martsevich" 1 => "M.L. Ginzburg" 2 => "N.P. Kutishenko" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rational Pharmacother Card" "fecha" => "2012" "volumen" => "8" "paginaInicial" => "681" "paginaFinal" => "684" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0140" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Length of initial prescription at hospital discharge and long-term medication adherence for elderly patients with coronary artery disease: a population-level study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N.M. Ivers" 1 => "J.D. Schwalm" 2 => "C.A. Jackevicius" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cjca.2013.04.009" "Revista" => array:6 [ "tituloSerie" => "Can J Cardiol" "fecha" => "2013" "volumen" => "29" "paginaInicial" => "1408" "paginaFinal" => "1414" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23816280" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0145" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Accounting for clinical action reduces estimates of gender disparities in lipid management for diabetic veterans" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "V.G. Vimalananda" 1 => "D.R. Miller" 2 => "T.P. Hofer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11606-013-2340-5" "Revista" => array:7 [ "tituloSerie" => "J Gen Intern Med" "fecha" => "2013" "volumen" => "28" "numero" => "Suppl 2" "paginaInicial" => "S529" "paginaFinal" => "S535" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23807061" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0150" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adherence to secondary prevention medications and four-year outcomes in outpatients with atherosclerosis; REduction of Atherothrombosis for Continued Health Registry Investigators" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.J. Kumbhani" 1 => "P.G. Steg" 2 => "C.P. Cannon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjmed.2013.01.033" "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "2013" "volumen" => "126" "paginaInicial" => "693" "paginaFinal" => "700" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23800583" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0155" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors influencing adherence in long-term use of statins" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.R. Warren" 1 => "M.O. Falster" 2 => "D. Fox" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/pds.3526" "Revista" => array:6 [ "tituloSerie" => "Pharmacoepidemiol Drug Saf" "fecha" => "2013" "volumen" => "22" "paginaInicial" => "1298" "paginaFinal" => "1307" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24105731" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0160" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of health information technology (HIT) to improve statin adherence and low-density lipoprotein cholesterol goal attainment in high-risk patients: proceedings from a workshop" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.D. Cohen" 1 => "K.E. Aspry" 2 => "A.S. Brown" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacl.2013.10.002" "Revista" => array:6 [ "tituloSerie" => "J Clin Lipidol" "fecha" => "2013" "volumen" => "7" "paginaInicial" => "573" "paginaFinal" => "609" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24314357" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21742049/0000003400000002/v2_201502270337/S217420491500032X/v2_201502270337/en/main.assets" "Apartado" => array:4 [ "identificador" => "9912" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original article" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21742049/0000003400000002/v2_201502270337/S217420491500032X/v2_201502270337/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217420491500032X?idApp=UINPBA00004E" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 5 | 9 |
| 2024 October | 31 | 30 | 61 |
| 2024 September | 40 | 24 | 64 |
| 2024 August | 41 | 26 | 67 |
| 2024 July | 34 | 32 | 66 |
| 2024 June | 29 | 21 | 50 |
| 2024 May | 32 | 26 | 58 |
| 2024 April | 24 | 18 | 42 |
| 2024 March | 30 | 18 | 48 |
| 2024 February | 26 | 16 | 42 |
| 2024 January | 20 | 23 | 43 |
| 2023 December | 21 | 28 | 49 |
| 2023 November | 26 | 22 | 48 |
| 2023 October | 19 | 18 | 37 |
| 2023 September | 16 | 26 | 42 |
| 2023 August | 20 | 17 | 37 |
| 2023 July | 43 | 11 | 54 |
| 2023 June | 20 | 18 | 38 |
| 2023 May | 64 | 24 | 88 |
| 2023 April | 15 | 5 | 20 |
| 2023 March | 14 | 16 | 30 |
| 2023 February | 33 | 17 | 50 |
| 2023 January | 56 | 6 | 62 |
| 2022 December | 30 | 19 | 49 |
| 2022 November | 28 | 20 | 48 |
| 2022 October | 23 | 10 | 33 |
| 2022 September | 26 | 31 | 57 |
| 2022 August | 24 | 29 | 53 |
| 2022 July | 31 | 24 | 55 |
| 2022 June | 29 | 16 | 45 |
| 2022 May | 24 | 38 | 62 |
| 2022 April | 24 | 14 | 38 |
| 2022 March | 27 | 32 | 59 |
| 2022 February | 25 | 14 | 39 |
| 2022 January | 18 | 25 | 43 |
| 2021 December | 22 | 24 | 46 |
| 2021 November | 36 | 32 | 68 |
| 2021 October | 28 | 36 | 64 |
| 2021 September | 20 | 25 | 45 |
| 2021 August | 21 | 30 | 51 |
| 2021 July | 18 | 28 | 46 |
| 2021 June | 20 | 15 | 35 |
| 2021 May | 34 | 20 | 54 |
| 2021 April | 44 | 46 | 90 |
| 2021 March | 75 | 15 | 90 |
| 2021 February | 59 | 7 | 66 |
| 2021 January | 37 | 12 | 49 |
| 2020 December | 32 | 5 | 37 |
| 2020 November | 31 | 14 | 45 |
| 2020 October | 24 | 6 | 30 |
| 2020 September | 51 | 13 | 64 |
| 2020 August | 29 | 7 | 36 |
| 2020 July | 59 | 6 | 65 |
| 2020 June | 33 | 1 | 34 |
| 2020 May | 55 | 6 | 61 |
| 2020 April | 47 | 3 | 50 |
| 2020 March | 48 | 5 | 53 |
| 2020 February | 36 | 47 | 83 |
| 2020 January | 27 | 6 | 33 |
| 2019 December | 35 | 9 | 44 |
| 2019 November | 48 | 13 | 61 |
| 2019 October | 37 | 5 | 42 |
| 2019 September | 17 | 10 | 27 |
| 2019 August | 21 | 6 | 27 |
| 2019 July | 29 | 5 | 34 |
| 2019 June | 20 | 13 | 33 |
| 2019 May | 24 | 9 | 33 |
| 2019 April | 30 | 18 | 48 |
| 2019 March | 62 | 10 | 72 |
| 2019 February | 88 | 16 | 104 |
| 2019 January | 83 | 4 | 87 |
| 2018 December | 82 | 12 | 94 |
| 2018 November | 158 | 8 | 166 |
| 2018 October | 344 | 15 | 359 |
| 2018 September | 118 | 14 | 132 |
| 2018 August | 147 | 17 | 164 |
| 2018 July | 42 | 9 | 51 |
| 2018 June | 54 | 9 | 63 |
| 2018 May | 56 | 11 | 67 |
| 2018 April | 76 | 14 | 90 |
| 2018 March | 74 | 8 | 82 |
| 2018 February | 62 | 4 | 66 |
| 2018 January | 111 | 6 | 117 |
| 2017 December | 181 | 10 | 191 |
| 2017 November | 48 | 13 | 61 |
| 2017 October | 28 | 15 | 43 |
| 2017 September | 28 | 7 | 35 |
| 2017 August | 26 | 14 | 40 |
| 2017 July | 22 | 9 | 31 |
| 2017 June | 36 | 9 | 45 |
| 2017 May | 32 | 16 | 48 |
| 2017 April | 25 | 10 | 35 |
| 2017 March | 28 | 15 | 43 |
| 2017 February | 26 | 5 | 31 |
| 2017 January | 30 | 5 | 35 |
| 2016 December | 36 | 11 | 47 |
| 2016 November | 30 | 4 | 34 |
| 2016 October | 31 | 5 | 36 |
| 2016 September | 24 | 12 | 36 |
| 2016 August | 8 | 2 | 10 |
| 2016 July | 11 | 5 | 16 |
| 2016 June | 11 | 6 | 17 |
| 2016 May | 11 | 7 | 18 |
| 2016 April | 12 | 6 | 18 |
| 2016 March | 46 | 17 | 63 |
| 2016 February | 34 | 17 | 51 |
| 2016 January | 15 | 17 | 32 |
| 2015 December | 14 | 12 | 26 |
| 2015 November | 21 | 14 | 35 |
| 2015 October | 18 | 16 | 34 |
| 2015 September | 28 | 9 | 37 |
| 2015 August | 26 | 12 | 38 |
| 2015 July | 11 | 5 | 16 |
| 2015 June | 25 | 11 | 36 |
| 2015 May | 28 | 19 | 47 |
| 2015 April | 19 | 7 | 26 |
| 2015 March | 30 | 8 | 38 |
| 2015 February | 1 | 1 | 2 |
Show all
