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João, Porto, Portugal" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Transplantação cardíaca – perspetivas atuais" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Over 40 years after the first successful heart transplant in humans, it remains the treatment of choice for a selected group of patients with advanced heart failure (HF), despite the considerable progress made in HF treatment.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Improved medical therapy has doubled the life expectancy of patients with HF and left ventricular (LV) systolic dysfunction,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> while in some patients cardiac resynchronization therapy can improve functional class, reduce the frequency of hospitalizations and increase survival, and implantable cardioverter-defibrillators reduce sudden death and late mortality.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a> A significant number of patients with coronary and/or valve disease are currently accepted for conventional cardiac surgery or ventricular volume reduction surgery, with good medium-term results.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Successive advances in ventricular assist devices, now in their fourth generation, mean that from the clinical standpoint, there are a variety of options available, ranging from temporary support and a bridge to possible transplantation to permanent therapy.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Although it is still the gold standard treatment for advanced HF, with expected survival of more than 10 years and improved functional capacity and quality of life, heart transplantation is reserved for a small group of patients, both because there are other therapeutic options for less advanced HF, and due to the inherent limitations of the technique.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> The pool of potential donors is relatively small, despite the fact that there is clinical consensus on optimizing management of donor hearts and increasing the use of marginal donors in particular circumstances.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> The cardiological criteria for the indication of heart transplantation are generally agreed, but a significant number of potential recipients are never considered for transplantation, either due to contraindication to a lifetime of immunosuppression or because of their age and/or comorbidities, given the need to optimize use of a scarce resource.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Although there has been gradual but sustained improvement in long-term outcomes following transplantation, there are barriers, so far insuperable, to significant progress. These include deterioration of graft function caused by chronic rejection, and progressive increases in malignancy and serious infection.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10,11</span></a> At least as important are the cost of the procedure and ethical and legal considerations, which differ from country to country, as well as the local availability of effective and reliable ventricular assist devices.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Heart transplantation is, therefore, increasingly an option for only a limited number of patients at very high risk, as the number of critical candidates, many of them under mechanical support, rises, and the number of outpatient candidates falls.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13,14</span></a> The combination of these factors has meant that the demand for heart transplantations has fallen to 5–7 per million population from the perceived need for 10 transplantations per million population 20 years ago. Furthermore, in wealthier countries, implantation of permanent ventricular assist devices or biventricular pacemakers is predicted to overtake heart transplantation, especially as clinical trials of LV assist devices have shown excellent short- and medium-term results in terms of quality-adjusted life years, although these tend to fall over time.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15,16</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">This state of affairs warrants some comment, especially in a country like Portugal, in which financial resources are scarce. The results of heart transplantation are better and more cost-effective when patients are treated before they reach a critical stage, and risk stratification can be improved with existing clinical decision instruments.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Furthermore, greater efforts should be made to take full advantage of potential donors, since at the moment it does not appear feasible to establish a ventricular assist device program, the cost-effectiveness ratio of which is still unacceptable for a country like Portugal.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> Finally, the work of heart transplantation teams (arguably the first heart teams of all) should be integrated into clinical units with knowledge and experience of state-of-the-art treatment of advanced HF. As the volume of procedures needs to remain high to ensure quality of treatment, other factors, such as the availability of alternative medical and surgical options as well as of different forms of circulatory support, and the size and demographics of referral areas, should also be taken into consideration.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The 10-year experience of the University Hospital of Coimbra reported in the article published in this issue of the <span class="elsevierStyleItalic">Journal</span> is an important contribution to our knowledge of the current situation regarding heart transplantation in Portugal.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> By Iberian standards, the Coimbra center's annual volume of activity is high, and they have accumulated considerable experience with over 250 procedures. Their long-term results are good, as are waiting times, graft ischemia times and candidates’ hemodynamic status. The authors provide a detailed description of recipients’ preoperative clinical characteristics, perioperative data and the early and late complications inherent to such procedures. It would have been interesting to see a comparison between different periods of the experience presented, as this would have shed light on recent developments in heart transplantation, such as changes in candidates’ degrees of priority, the results of using marginal donors, and the effects of modifying treatment protocols. These will undoubtedly be the subject of future studies.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Pinho P. Transplantação cardíaca – perspetivas atuais. Rev Port Cardiol. 2014;33:683–684.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The operation. A human cardiac transplant: an interim report of a successful operation performed at Groote Schuur Hospital, Cape Town" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.N. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 6 | 5 | 11 |
2024 October | 33 | 30 | 63 |
2024 September | 31 | 25 | 56 |
2024 August | 52 | 31 | 83 |
2024 July | 28 | 34 | 62 |
2024 June | 22 | 17 | 39 |
2024 May | 26 | 19 | 45 |
2024 April | 24 | 27 | 51 |
2024 March | 21 | 22 | 43 |
2024 February | 26 | 25 | 51 |
2024 January | 18 | 25 | 43 |
2023 December | 16 | 21 | 37 |
2023 November | 20 | 20 | 40 |
2023 October | 15 | 18 | 33 |
2023 September | 23 | 21 | 44 |
2023 August | 17 | 16 | 33 |
2023 July | 20 | 8 | 28 |
2023 June | 20 | 10 | 30 |
2023 May | 25 | 27 | 52 |
2023 April | 13 | 7 | 20 |
2023 March | 27 | 25 | 52 |
2023 February | 18 | 29 | 47 |
2023 January | 17 | 17 | 34 |
2022 December | 30 | 24 | 54 |
2022 November | 37 | 28 | 65 |
2022 October | 67 | 18 | 85 |
2022 September | 46 | 36 | 82 |
2022 August | 42 | 32 | 74 |
2022 July | 46 | 34 | 80 |
2022 June | 51 | 20 | 71 |
2022 May | 39 | 36 | 75 |
2022 April | 29 | 24 | 53 |
2022 March | 23 | 34 | 57 |
2022 February | 23 | 21 | 44 |
2022 January | 19 | 30 | 49 |
2021 December | 22 | 31 | 53 |
2021 November | 22 | 31 | 53 |
2021 October | 18 | 38 | 56 |
2021 September | 19 | 27 | 46 |
2021 August | 18 | 26 | 44 |
2021 July | 12 | 29 | 41 |
2021 June | 14 | 18 | 32 |
2021 May | 18 | 29 | 47 |
2021 April | 55 | 35 | 90 |
2021 March | 72 | 9 | 81 |
2021 February | 47 | 13 | 60 |
2021 January | 26 | 11 | 37 |
2020 December | 17 | 5 | 22 |
2020 November | 18 | 12 | 30 |
2020 October | 17 | 8 | 25 |
2020 September | 22 | 6 | 28 |
2020 August | 22 | 6 | 28 |
2020 July | 28 | 8 | 36 |
2020 June | 31 | 3 | 34 |
2020 May | 13 | 4 | 17 |
2020 April | 35 | 13 | 48 |
2020 March | 16 | 4 | 20 |
2020 February | 19 | 14 | 33 |
2020 January | 20 | 13 | 33 |
2019 December | 12 | 2 | 14 |
2019 November | 23 | 8 | 31 |
2019 October | 18 | 5 | 23 |
2019 September | 11 | 11 | 22 |
2019 August | 30 | 6 | 36 |
2019 July | 29 | 11 | 40 |
2019 June | 15 | 6 | 21 |
2019 May | 22 | 5 | 27 |
2019 April | 27 | 12 | 39 |
2019 March | 17 | 13 | 30 |
2019 February | 33 | 8 | 41 |
2019 January | 39 | 6 | 45 |
2018 December | 29 | 9 | 38 |
2018 November | 47 | 11 | 58 |
2018 October | 67 | 19 | 86 |
2018 September | 36 | 13 | 49 |
2018 August | 30 | 6 | 36 |
2018 July | 14 | 2 | 16 |
2018 June | 32 | 6 | 38 |
2018 May | 28 | 7 | 35 |
2018 April | 48 | 4 | 52 |
2018 March | 60 | 9 | 69 |
2018 February | 38 | 5 | 43 |
2018 January | 50 | 4 | 54 |
2017 December | 33 | 4 | 37 |
2017 November | 26 | 8 | 34 |
2017 October | 31 | 9 | 40 |
2017 September | 23 | 7 | 30 |
2017 August | 40 | 14 | 54 |
2017 July | 19 | 11 | 30 |
2017 June | 38 | 9 | 47 |
2017 May | 38 | 6 | 44 |
2017 April | 23 | 2 | 25 |
2017 March | 34 | 23 | 57 |
2017 February | 35 | 5 | 40 |
2017 January | 34 | 2 | 36 |
2016 December | 35 | 9 | 44 |
2016 November | 24 | 13 | 37 |
2016 October | 31 | 3 | 34 |
2016 September | 29 | 8 | 37 |
2016 August | 4 | 1 | 5 |
2016 July | 9 | 3 | 12 |
2016 June | 14 | 1 | 15 |
2016 May | 14 | 3 | 17 |
2016 April | 28 | 29 | 57 |
2016 March | 34 | 17 | 51 |
2016 February | 61 | 27 | 88 |
2016 January | 38 | 26 | 64 |
2015 December | 37 | 17 | 54 |
2015 November | 45 | 10 | 55 |
2015 October | 58 | 9 | 67 |
2015 September | 66 | 14 | 80 |
2015 August | 39 | 10 | 49 |
2015 July | 40 | 9 | 49 |
2015 June | 21 | 2 | 23 |
2015 May | 39 | 9 | 48 |
2015 April | 28 | 9 | 37 |
2015 March | 65 | 6 | 71 |
2015 February | 27 | 11 | 38 |
2015 January | 34 | 21 | 55 |
2014 December | 25 | 12 | 37 |