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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introduction</span><p id="par0090" class="elsevierStylePara elsevierViewall">Cardiovascular disease &#40;CVD&#41; is the leading cause of death worldwide&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> According to the Global Atlas on Cardiovascular Disease Prevention and Control published by the World Health Organization&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> of the 57 million deaths that occurred globally in 2008&#44; 17&#46;3 million &#40;30&#37;&#41; were due to CVD&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">A common element in CVD&#44; including myocardial infarction &#40;MI&#41;&#44; is a detrimental change in cardiac autonomic modulation&#44; i&#46;e&#46;&#44; increased sympathetic outflow and reduced parasympathetic activity&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Cardiac autonomic modulation refers to the influence that these two branches of the autonomic nervous system have on the heart&#58; they interact in a complex way to regulate the heart&#39;s chronotropism&#44; dromotropism&#44; and inotropism&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Soon after MI&#44; autonomic imbalance acts to preserve the proper functioning of the cardiovascular system and consequently of the whole body&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Nevertheless&#44; the maintenance of this imbalance can lead to harmful consequences in MI patients&#44; such as decreased cardiomyocyte viability due to the cytotoxic effect of elevated catecholamine levels<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> and adverse cardiac remodeling&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;8</span></a> Simultaneously&#44; myocardial overload&#44; due to the elevated heart rate &#40;HR&#41; and contractility induced by sympathetic overactivity&#44; increases oxygen demand and reduces coronary perfusion time&#44; impairing coronary blood flow in the weakened myocardium and thereby increasing the likelihood of ischemic insult and malignant ventricular arrhythmias and hence the risk of sudden cardiac death&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">A relatively easy noninvasive method that is reproducible and cost-effective for estimating cardiac autonomic modulation is evaluation of heart rate variability &#40;HRV&#41;&#44; which analyzes variations in the intervals between consecutive normal heart beats or normal R wave peaks &#40;i&#46;e&#46;&#44; RR or NN intervals&#41;&#44; measured in ms&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;11</span></a> Depressed HRV suggests poor functioning of cardiac autonomic modulation and therefore impaired ability of the heart to adapt to a range of physiological and environmental stimuli&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Various HRV indices have been used to stratify the risk of mortality and cardiovascular events in patients after MI&#44; and have shown promising results&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#8211;15</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Recommendations to join exercise training programs and to increase daily physical activity levels are included in the guidelines for secondary prevention through cardiac rehabilitation in patients with documented coronary artery disease &#40;CAD&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;17</span></a> Exercise-based cardiac rehabilitation has been shown to be an effective therapy for reducing mortality and morbidity in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> There are many documented benefits arising from exercise training&#44; such as improvements in aerobic fitness&#44; exercise capacity&#44; ventilatory threshold&#44; modifiable cardiovascular disease risk factors&#44; endothelial function&#44; and vascular wall inflammation&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#8211;21</span></a> The effect of exercise-based cardiac rehabilitation on the impaired autonomic function of CAD patients has also been studied&#44;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#8211;24</span></a> although there are conflicting results regarding the impact of exercise training on HRV&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">This review aims to provide a critical appraisal of the literature linking exercise training and autonomic function in MI patients and a discussion of the possible mechanisms underlying the effects of exercise training on autonomic function&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Heart rate variability indices and prognostic implications</span><p id="par0115" class="elsevierStylePara elsevierViewall">It is not the main purpose of the present review to describe the HRV indices employed in the literature&#59; this has been done in detail by Malik et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and Kleiger et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> However&#44; it is important to mention that traditional methods&#44; based on time and frequency domains&#44; are by far the most commonly used&#46; The main time domain indices include the standard deviation of all NN intervals &#40;SDNN&#41;&#44; the standard deviation of average NN intervals calculated from 5-minute segments &#40;SDANN&#41;&#44; the square root of the mean of the squared differences between successive NN intervals &#40;RMSSD&#41;&#44; and the percentage of successive NN intervals differing by &#62;50 ms &#40;pNN50&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;11</span></a> Frequency domain indices include low-frequency &#40;LF&#41; peak &#40;0&#46;04&#8211;0&#46;15 Hz&#41;&#44; high-frequency peak &#40;0&#46;15&#8211;0&#46;4 Hz&#41;&#44; expressed in absolute units of power &#40;ms<span class="elsevierStyleSup">2</span>&#41; or in normalized units &#40;nu&#41;&#44; and the ratio between them &#40;LF&#47;HF&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;11</span></a> It is widely accepted that in general&#44; time domain variables are related to each other and are affected to different degrees by parasympathetic blockade&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> Recent evidence supports the idea that they are markers of parasympathetic cardiac modulation&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> Nevertheless&#44; HF peak is established as the foremost HRV marker of efferent cardiac vagal activity &#40;i&#46;e&#46;&#44; vagal modulation of HR&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> There is no consensus regarding interpretation of the LF component&#44; but it is considered a marker of both sympathetic and parasympathetic modulation&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> Lastly&#44; the LF&#47;HF ratio has been reported as a measure of sympathovagal balance&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Various studies have been conducted to investigate the prognostic value of HRV after acute MI&#44; employing&#58; &#40;i&#41; different methods to analyze HRV data &#40;e&#46;g&#46;&#44; traditional&#44; geometric&#44; and nonlinear&#41;&#44; &#40;ii&#41; different periods of time after MI to evaluate baseline HRV &#40;from days to weeks or months&#41;&#44; &#40;iii&#41; different follow-up periods &#40;from months to years&#41;&#44; and &#40;iv&#41; different end-points &#40;e&#46;g&#46;&#44; arrhythmic events&#44; cardiac death&#44; sudden death&#44; and all-cause mortality&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#8211;15</span></a> Kleiger et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> in an elegant study&#44; evaluated HRV with 24-hour Holter ECG monitoring in 808 patients recovering from MI &#40;11&#177;3 days after the acute event&#41;&#44; and observed a relative risk of all-cause mortality of 2&#46;7 for those with SDNN &#60;50 ms compared to those with SDNN &#8805;50 ms&#44; after a 31-month follow-up&#46; In addition&#44; after adjusting for measures such as ejection fraction&#44; exercise capacity&#44; post-infarction angina&#44; ventricular arrhythmias&#44; and drug treatment&#44; SDNN was established as an independent predictor of mortality&#46; La Rovere et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> in the Autonomic Tone and Reflexes After Myocardial Infarction &#40;ATRAMI&#41; study&#44; assessed 24-hour Holter HRV in a representative sample of recent &#40;&#60;28 days&#41; post-MI patients &#40;n&#61;1284&#41;&#44; of whom 63&#37; received thrombolytic therapy&#46; Over a mean follow-up of 21&#177;8 months&#44; it was observed that both one- and two-year cardiac mortality were higher among patients with SDNN &#60;70 ms&#46; In addition&#44; Bigger et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> evaluating LF and HF among other frequency domain indices&#44; found that reduced levels of all measures were predictors of arrhythmic&#44; all-cause&#44; and cardiac mortality over a follow-up of two to four years&#46; To summarize&#44; these findings show that various HRV indices can provide valuable prognostic information on MI patients&#46; However&#44; for the purpose of dichotomous risk stratification in clinical practice&#44; diverse HRV cut-off points have been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> For instance&#44; Kleiger et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> applied a cut-off of SDNN &#60;50 ms&#44; while in the ATRAMI study<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> the cut-off was defined as SDNN &#60;70 ms to differentiate MI patients with impaired HRV and consequently increased risk of developing the assessed end-points&#46; Besides the conflicting results&#44; the establishment of a single cut-off point did not allow normal HRV values to be distinguished from moderately and severely abnormal HRV values&#46; This was the aim of Milicevic et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> who analyzed various HRV indices in cardiac inpatient and outpatient groups&#46; For the entire sample&#44; the range of moderately depressed SDNN values was 59&#8211;92 ms&#44; with values above these limits being considered normal&#44; and below severely depressed&#46; On the other hand&#44; different values were expressed when the sample analysis was performed by gender and group&#46; For outpatients&#44; a moderately depressed SDNN was 75&#8211;105 ms for females and 65&#8211;100 ms for males&#46; For inpatients attending a rehabilitation program&#44; a moderately depressed SDNN was 47&#8211;74 ms for females and 53&#8211;83 ms for males&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">There are numerous reasons for the considerable variability in the ranges of SDNN and other HRV indices&#58; differences in infarct location and size&#44; differences in age&#44; gender&#44; and experimental conditions&#44; and difference in the statistical approach for data analysis&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4</span></a> In view of this variety&#44; dichotomized cut-off points or ranges to define normal&#44; moderately abnormal&#44; and severely abnormal HRV values have not been universally accepted&#44; and further investigation and debate are thus warranted on this issue&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Effects of exercise training on heart rate variability in myocardial infarction patients</span><p id="par0130" class="elsevierStylePara elsevierViewall">Exercise-based cardiac rehabilitation has been shown to provide various health-related benefits&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> including improvements in exercise tolerance&#44; endothelial function&#44; cardiovascular risk factors&#44; and vascular wall inflammation&#44; which can collectively reduce morbidity and mortality in CAD patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;21&#44;29&#44;30</span></a> A meta-analysis of 47 studies randomizing 10<span class="elsevierStyleHsp" style=""></span>794 CAD patients to exercise-based cardiac rehabilitation or usual care found significant reductions in total mortality &#40;13&#37;&#41;&#44; cardiac mortality &#40;26&#37;&#41;&#44; and hospital admissions &#40;31&#37;&#41; in patients who exercised in a mean follow-up of 12 months or more&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> Furthermore&#44; a significant reduction in sudden cardiac death &#40;37&#37;&#41; was also observed in CAD patients participating in exercise training compared to usual medical care&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">As reduced HRV in CAD patients is associated with increased risk of all-cause mortality&#44; cardiac mortality&#44; and sudden death&#44; one possible explanation for the reduction in morbidity and mortality in patients undergoing exercise-based cardiac rehabilitation could be exercise-induced improvement in cardiac autonomic modulation&#46; However&#44; no prospective study has been performed to test this hypothesis&#46; Studies in healthy trained subjects undergoing aerobic exercise training<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">31&#8211;33</span></a> have shown increased vagal and&#47;or reduced sympathetic cardiac modulation&#44; characterized by resting bradycardia and increased vagal-related HRV indices&#44; compared to sedentary controls&#46; Regarding the effects of exercise-based cardiac rehabilitation on HRV indices &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#44; data from studies on post-MI patients have revealed heterogeneous results&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#8211;24&#44;34&#8211;42</span></a> However&#44; not all of these studies were randomized controlled trials&#44; which to some extent weakens their conclusions&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0140" class="elsevierStylePara elsevierViewall">In a randomized controlled study&#44; Duru et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> assessed the time and frequency domain HRV &#40;short-term&#44; 30 min&#41; of 25 post-MI patients&#44; before and after an eight-week cycling&#47;walking exercise program at roughly 70&#37; of their HR reserve or on usual medical care only&#44; and found no differences in HRV indices&#46; Other studies showed similar results&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">34&#8211;36</span></a> La Rovere et al&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> also found no enhancement in frequency domain HRV indices at rest after a four-week exercise training program with calisthenics and cycle ergometer at 75&#8211;95&#37; of anaerobic threshold&#46; However&#44; the exercise-training program significantly increased LF and decreased HF in response to the head-up tilt test&#46; The fact that these responses were more marked in the trained group than in controls suggests that the reflex activity of the autonomic system may have been improved by a short-term exercise training program&#46; A study comprising a very short &#40;two weeks&#41; exercise training program at an intensity corresponding to the anaerobic threshold also showed no significant effect on the HF component of HRV at rest&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> Nevertheless&#44; during a constant load exercise test &#40;20 W&#41;&#44; a significant increase in HF was observed in the trained group&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> Similar results during a constant load exercise test &#40;20 W&#41; were reported by Oya et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> who observed an HF delta value of 30&#177;6 ms<span class="elsevierStyleSup">2</span>&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Significant improvements in the HRV of the trained group compared to control groups were also reported in some randomized controlled trials&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#44;39&#8211;41</span></a> Forty patients&#44; enrolled two weeks after their first uncomplicated MI&#44; were randomly allocated to two-week exercise training on a cycle ergometer performed twice a day at an intensity of 80&#37; of their anaerobic threshold or to the control group &#40;n&#61;20&#41;&#46; Following exercise training&#44; SDNN increased significantly from 104&#46;9&#177;16&#46;3 to 121&#46;7&#177;26&#46;8 ms&#44; SDANN from 89&#46;4&#177;17&#46;4 to 106&#46;9&#177;28&#46;5 ms&#44; and HF from 82&#46;5&#177;56&#46;2 to 131&#46;1&#177;99&#46;8 ms<span class="elsevierStyleSup">2</span>&#44; while the LF&#47;HF ratio decreased from 3&#46;9&#177;2&#46;2 to 2&#46;6&#177;1&#46;3&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> Iellamo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> applied a similar exercise program in 45 patients with and without previous MI&#46; After two weeks of training&#44; the resting RR interval was increased by a significant 7&#37; and SDNN by 26&#37; in the exercise group only &#40;both MI and non-MI patients&#41;&#46; Stahle et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> also reported higher HRV values &#40;daytime SDNN and SDANN&#41; for the exercise group after a three-month training period&#46; Likewise&#44; a more recent study was conducted on a heterogeneous sample of CAD patients&#44; of whom at least half had previous MI&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> Eighty-four patients were randomly allocated to a control or exercise group and after eight weeks of exercise training&#44; the exercise group showed a 10&#37; increase in HF power and 5&#37; in the mean of RR intervals&#44; while in the control group these indices decreased&#46; Furthermore&#44; it was observed that the acute MI patients presented greater increases in HRV indices than those without acute MI&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Although not randomized&#44; two studies by Malfatto et al&#46;&#44; <a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24&#44;42</span></a> deserve mention&#44; especially regarding their design&#46; In these studies&#44; post-MI patients underwent supervised aerobic exercise five times a week for eight weeks&#46; Afterwards&#44; a non-supervised exercise schedule was prescribed to be followed for one year&#46; Compliance with this schedule was assessed by phone calls&#46; In the first study&#44;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a> SDNN&#44; RMSSD&#44; and pNN50 increased and LF&#47;HF ratio decreased in the training group after exercise training by 25&#37;&#44; 69&#37;&#44; 120&#37;&#44; and 30&#37;&#44; respectively&#46; In the second study&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> the same HRV indices improved in two of three patient groups&#44; one treated with exercise-based cardiac rehabilitation only and another with the addition of beta-blocker therapy&#46; The third group&#44; treated only with beta-blockers&#44; showed no change in HRV&#46; Moreover&#44; the higher vagal tone observed in the combined-therapy group compared to the exercise-only group suggests an additive effect with the two therapies&#46; After one year&#44; in both studies&#44; the positive effects on HRV were maintained in the groups that underwent supervised exercise and had followed the non-supervised exercise schedule&#46; The latter finding indicates a long-term beneficial effect in patients who complied with the home-based exercise schedule&#44; which was later confirmed by the same research group in a different study&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a> The beneficial effect on HRV of a home-based exercise program was suggested in a study by Leitch et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> In this study&#44; 49 patients with uncomplicated MI were randomly allocated to a six-week hospital-based exercise training program plus an unsupervised low-intensity home walking program &#40;exercise group&#41; or to a home walking program only &#40;control group&#41;&#46; The authors reported significant improvements in all HRV indices in both groups&#46; However&#44; the lack of a true control group makes it impossible to exclude the possibility that the natural recovery of HRV after the acute event could have contributed to the results&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">There may be several reasons for the conflicting results reported by the above-mentioned studies&#44; such as small sample sizes&#44; dissimilar inclusion and exclusion criteria &#40;e&#46;g&#46;&#44; patients over 70 years old&#41;&#44; mixed groups of cardiac patients &#40;acute MI vs&#46; angina&#44; coronary artery bypass grafting &#91;CABG&#93; vs&#46; percutaneous transluminal coronary angioplasty &#91;PTCA&#93;&#41;&#44; the baseline assessment being performed at different times after the acute event&#44; lack of data on infarct size and location&#44; and lack of control of potentially confounding variables such as dietary intake and daily physical activity performed by the study groups apart from the exercise training program&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;35&#44;36&#44;40&#44;44</span></a> Other possible explanations include different methods and protocols used to assess HRV&#44; such as the mathematical methods to calculate the power spectral density &#40;autoregressive and fast Fourier transform&#41;&#44; and the period used to record RR interval data&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#44;34&#44;37&#44;39&#44;45</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">Furthermore&#44; in short-term recordings of HRV&#44; a critical element in the comparison of outcomes is data on breathing frequency&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a> which was not reported in some studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23&#44;34&#44;41</span></a> In addition&#44; high baseline HRV values could limit the magnitude of changes induced by therapeutic exercise&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> Similarly&#44; a plateau or saturation point has been reported&#44; particularly in individuals with high vagal activity or with very low resting HR&#44; beyond which there is no further increase in HRV or in indices related to cardiac vagal modulation &#40;especially HF&#41; with increases in cardiac vagal activity&#59; indeed&#44; there may even be a reduction in HRV&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">47&#44;48</span></a> Thus&#44; a simple statistical analysis including these individuals together with those with low cardiac vagal activity could have underestimated the beneficial effect of exercise&#46; In these cases&#44; a stratified analysis by baseline HRV values is recommended&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Regarding studies reporting beneficial effects of exercise on HRV&#44; it is not possible to clearly ascertain which is the best combination of exercise training variables &#40;duration of the program&#44; mode of exercise&#44; intensity&#44; and frequency&#41; to enhance HRV&#46; Similar exercise training programs have provided different outcomes and&#44; in addition&#44; some studies do not provide complete information on training load variables&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;37&#8211;39&#44;41</span></a> Conversely&#44; studies with dissimilar training designs have shown significant improvements in HRV&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#44;41</span></a> On the other hand&#44; four weeks of aerobic exercise training at 75&#8211;95&#37; of anaerobic threshold did not increase HRV&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> whereas only two weeks of a similar training program were able to raise some HRV indices&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> Further studies are thus needed to examine the exercise-dose relationship required to improve HRV&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Mechanisms related to enhanced cardiac vagal modulation after exercise training</span><p id="par0170" class="elsevierStylePara elsevierViewall">Understanding of the mechanisms responsible for the therapeutic effect of exercise training on cardiac autonomic modulation and on HRV is limited&#46; Nevertheless&#44; studies on animals and humans have provided some indications&#44; including decreases in catecholamine levels&#44; beta-adrenergic receptor density and angiotensin II&#44; and increased nitric oxide &#40;NO&#41; bioavailability&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">The effects of exercise training on catecholamine levels have been studied in cardiovascular disease patients&#44; particularly in heart failure patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">49&#44;50</span></a> Coats et al&#46; found a decrease in whole-body norepinephrine spillover following exercise training&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> In another study with heart failure patients enrolled in a six-month exercise-training program&#44; resting plasma norepinephrine and epinephrine concentrations fell after training by 52&#37; and 50&#37;&#44; respectively&#44; while the control group showed no changes&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a> Even without a significant decrease in catecholamine levels&#44; exercise training can have a positive effect by reducing adrenergic receptor density&#59; a study in animal models showed that a 10-week aerobic exercise program induced a significant reduction in beta-adrenergic receptor density&#44; which was associated with bradycardia in trained animals&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">Another mechanism that could contribute to increased cardiac vagal modulation after exercise training is the increased cardiac acetylcholine content and choline acetyltransferase activity observed in the hearts of trained rats&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">A reduction in angiotensin II levels also appears to have an important influence on parasympathetic activity&#44; as this peptide has been shown to increase sympathetic outflow and reduce vagal activity&#46;<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">53&#44;54</span></a> A study using an animal model reported a significant decrease in angiotensin II levels in rats undergoing aerobic exercise training&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a> Additionally&#44; longitudinal studies have reported significant reductions in plasma renin with training&#44;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">56&#44;57</span></a> and cross-sectional studies have observed reduced plasma renin activity in runners compared to sedentary individuals&#46;<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">58&#44;59</span></a> Nevertheless&#44; a recent study in hypertensive patients indicated that aerobic exercise training improved cardiac autonomic function independently of angiotensin-converting enzyme inhibitor treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> Thus&#44; other potential mechanisms should be considered when analyzing the effects of exercise training on HRV&#44; such as increased NO bioavailability&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Findings from animal and human research have shown that NO increases vagal activity at central and peripheral sites&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">61&#8211;64</span></a> The favorable effect of exercise training on NO bioavailability may be due to increased production and&#47;or decreased degradation&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Hambrecht et al&#46; showed increased expression and phosphorylation of endothelial NO synthase in CAD patients after aerobic exercise training&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">65</span></a> There is also evidence of increased neuronal NO synthase activity after exercise training&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">66</span></a> In addition&#44; overexpression of neuronal NO synthase in rats led to a significant attenuation of the increase in renal sympathetic nerve activity mediated by angiotensin II&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a> Exercise training also reduces NO degradation by increasing antioxidant defenses&#44; particularly by increasing the activity of superoxide dismutase and glutathione peroxidase&#46;<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">67&#44;68</span></a> Exercise training thus increases NO bioavailability and this may mediate the effect of exercise on cardiac vagal activity&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="par0195" class="elsevierStylePara elsevierViewall">Current knowledge shows that post-MI patients exhibit unbalanced cardiac autonomic function&#44; with predominance of the sympathetic nervous system to the detriment of the parasympathetic system&#46; This can be manifested by reduced HRV&#44; which has been associated with increased risk of malignant ventricular arrhythmias&#44; subsequent sudden death&#44; and other cardiovascular events in these patients&#46; However&#44; cut-off or reference values for the different indices of HRV are not well established&#44; which hampers their use in clinical practice for risk and prognostic stratification&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">Despite the conflicting evidence&#44; exercise training appears to be a useful therapeutic intervention to improve the unbalanced autonomic function of MI patients&#46; Nevertheless&#44; the small number of randomized controlled trials&#44; the lack of uniformity in study designs&#44; and the lack of control of potentially confounding variables should be taken into account&#46; Furthermore&#44; from studies observing an increase in cardiac vagal activity after aerobic exercise programs&#44;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#44;39&#8211;41</span></a> it is not possible to establish the best combination of training load variables &#40;length of the exercise program&#44; exercise mode&#44; intensity&#44; frequency&#44; and duration&#41; to enhance HRV&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Finally&#44; the possible mechanisms underlying the effects of exercise on cardiac autonomic modulation are not yet well understood&#44; but some studies have shown that nitric oxide bioavailability and angiotensin II levels play an important role&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Ethical disclosures</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Protection of human and animal subjects</span><p id="par0210" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Confidentiality of data</span><p id="par0215" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Right to privacy and informed consent</span><p id="par0220" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Funding</span><p id="par0225" class="elsevierStylePara elsevierViewall">This work was funded by <span class="elsevierStyleGrantSponsor" id="gs0005">FEDER &#40;European Regional Development Fund&#41;</span> through the Operational Competitiveness Programme &#40;COMPETE&#41;&#44; and by the <span class="elsevierStyleGrantSponsor" id="gs0010">Portuguese Foundation for Science and Technology &#40;FCT&#41;</span> within the projects FCOMP-01-0124-FEDER-014706 &#40;reference&#58; FCT&#58; PTDC&#47;DES&#47;113753&#47;2009&#41; and PEst-OE&#47;SAU&#47;UI0617&#47;2011&#46; FCT has supported the authors N&#243;rton Lu&#237;s Oliveira &#40;grant no&#46; SFRH&#47;BD&#47;48875&#47;2008&#41; and Fernando Ribeiro &#40;grant no&#46; SFRH&#47;BPD&#47;69965&#47;2010&#41;&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conflicts of interests</span><p id="par0230" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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          "titulo" => "Heart rate variability indices and prognostic implications"
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          "titulo" => "Effects of exercise training on heart rate variability in myocardial infarction patients"
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          "titulo" => "Mechanisms related to enhanced cardiac vagal modulation after exercise training"
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            0 => "Variabilidade da frequ&#234;ncia card&#237;aca"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Heart rate variability &#40;HRV&#41; is a simple and noninvasive measure that estimates cardiac autonomic modulation&#44; mainly the parasympathetic contribution&#46; Increased sympathetic and&#47;or decreased parasympathetic nervous activity is seen in post-myocardial infarction &#40;MI&#41; patients&#46; Consequently&#44; these patients present reduced HRV&#44; which has been associated with increased risk of adverse events and mortality&#46; Exercise training&#44; recommended as a complementary therapy for patients with cardiovascular disease&#44; has shown numerous beneficial effects&#46; The main aim of the present manuscript was to provide a critical review of studies investigating the effects of exercise training on cardiac autonomic modulation&#44; through HRV&#44; in MI patients and the possible mechanisms involved&#46; Despite conflicting evidence&#44; exercise training appears to be a useful therapeutic intervention to improve the unbalanced autonomic function of MI patients&#46; Finally&#44; the mechanisms involved are not yet well understood&#44; but nitric oxide bioavailability and angiotensin II levels seem to play an important role&#46;</p>"
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      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A variabilidade da frequ&#234;ncia card&#237;aca &#233; uma medida simples e n&#227;o invasiva da modula&#231;&#227;o auton&#243;mica card&#237;aca&#44; principalmente da contribui&#231;&#227;o da divis&#227;o parassimp&#225;tica&#46; O aumento da atividade simp&#225;tica e&#47;ou a diminui&#231;&#227;o da atividade parassimp&#225;tica ocorre em doentes com enfarte agudo do mioc&#225;rdio&#46; Consequentemente&#44; estes doentes apresentam reduzida variabilidade da frequ&#234;ncia card&#237;aca&#44; a qual tem sido associada com risco aumentado de eventos card&#237;acos adversos e de mortalidade&#46; Existem evid&#234;ncias de numerosos benef&#237;cios do exerc&#237;cio f&#237;sico regular&#44; quando recomendado como terap&#234;utica coadjuvante em sujeitos com doen&#231;a cardiovascular&#46; Assim sendo&#44; o prop&#243;sito do presente artigo &#233; a realiza&#231;&#227;o de uma revis&#227;o cr&#237;tica dos estudos investigando o efeito do exerc&#237;cio f&#237;sico regular na variabilidade da frequ&#234;ncia card&#237;aca e os potenciais mecanismos em doentes com hist&#243;ria de enfarte agudo do mioc&#225;rdio&#46; O exerc&#237;cio f&#237;sico regular parece ser um meio terap&#234;utico para melhorar a desregula&#231;&#227;o da fun&#231;&#227;o do sistema nervoso aut&#243;nomo em doentes com hist&#243;ria de enfarte agudo do mioc&#225;rdio&#44; apesar de os resultados contradit&#243;rios entre os estudos&#46; Finalmente&#44; n&#227;o est&#227;o claramente estabelecidos os poss&#237;veis mecanismos pelos quais o exerc&#237;cio melhora a variabilidade da frequ&#234;ncia card&#237;aca&#44; mas o aumento da biodisponibilidade do &#243;xido n&#237;trico e a redu&#231;&#227;o dos n&#237;veis de angiotensina II induzidos pelo exerc&#237;cio parecem desempenhar um importante papel&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Oliveira NL&#44; Ribeiro F&#44; Alves AJ&#44; Teixeira M&#44; Miranda F&#44; Oliveira J&#46; Variabilidade da frequ&#234;ncia card&#237;aca em pacientes ap&#243;s enfarte do mioc&#225;rdio&#58; efeitos do exerc&#237;cio f&#237;sico regular 2012&#46; http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;&#46;</p>"
      ]
    ]
    "nomenclatura" => array:1 [
      0 => array:3 [
        "identificador" => "nom0005"
        "titulo" => "<span class="elsevierStyleSectionTitle" id="sect0025">List of abbreviations</span>"
        "listaDefinicion" => array:1 [
          0 => array:1 [
            "definicion" => array:17 [
              0 => array:2 [
                "termino" => "ATRAMI"
                "descripcion" => "<p id="par0005" class="elsevierStylePara elsevierViewall">Autonomic Tone and Reflexes After Myocardial Infarction study</p>"
              ]
              1 => array:2 [
                "termino" => "CABG"
                "descripcion" => "<p id="par0010" class="elsevierStylePara elsevierViewall">coronary artery bypass grafting</p>"
              ]
              2 => array:2 [
                "termino" => "CAD"
                "descripcion" => "<p id="par0015" class="elsevierStylePara elsevierViewall">coronary artery disease</p>"
              ]
              3 => array:2 [
                "termino" => "CVD"
                "descripcion" => "<p id="par0020" class="elsevierStylePara elsevierViewall">cardiovascular disease</p>"
              ]
              4 => array:2 [
                "termino" => "HF"
                "descripcion" => "<p id="par0025" class="elsevierStylePara elsevierViewall">high-frequency peak</p>"
              ]
              5 => array:2 [
                "termino" => "HR"
                "descripcion" => "<p id="par0030" class="elsevierStylePara elsevierViewall">heart rate</p>"
              ]
              6 => array:2 [
                "termino" => "HRV"
                "descripcion" => "<p id="par0035" class="elsevierStylePara elsevierViewall">heart rate variability</p>"
              ]
              7 => array:2 [
                "termino" => "LF"
                "descripcion" => "<p id="par0040" class="elsevierStylePara elsevierViewall">low-frequency peak</p>"
              ]
              8 => array:2 [
                "termino" => "LF&#47;HF"
                "descripcion" => "<p id="par0045" class="elsevierStylePara elsevierViewall">ratio between low-frequency and high-frequency peak</p>"
              ]
              9 => array:2 [
                "termino" => "MI"
                "descripcion" => "<p id="par0050" class="elsevierStylePara elsevierViewall">myocardial infarction</p>"
              ]
              10 => array:2 [
                "termino" => "NN or RR intervals"
                "descripcion" => "<p id="par0055" class="elsevierStylePara elsevierViewall">intervals between consecutive normal heart beats or normal R wave peaks</p>"
              ]
              11 => array:2 [
                "termino" => "NO"
                "descripcion" => "<p id="par0060" class="elsevierStylePara elsevierViewall">nitric oxide</p>"
              ]
              12 => array:2 [
                "termino" => "pNN50"
                "descripcion" => "<p id="par0065" class="elsevierStylePara elsevierViewall">percentage of successive NN intervals differing by &#62;50 ms</p>"
              ]
              13 => array:2 [
                "termino" => "PTCA"
                "descripcion" => "<p id="par0070" class="elsevierStylePara elsevierViewall">percutaneous transluminal coronary angioplasty</p>"
              ]
              14 => array:2 [
                "termino" => "RMSSD"
                "descripcion" => "<p id="par0075" class="elsevierStylePara elsevierViewall">square root of the mean of the squared differences between successive NN intervals</p>"
              ]
              15 => array:2 [
                "termino" => "SDANN"
                "descripcion" => "<p id="par0080" class="elsevierStylePara elsevierViewall">standard deviation of average NN intervals calculated from 5-minute segments</p>"
              ]
              16 => array:2 [
                "termino" => "SDNN"
                "descripcion" => "<p id="par0085" class="elsevierStylePara elsevierViewall">standard deviation of all NN intervals</p>"
              ]
            ]
          ]
        ]
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Age&#58; mean &#177; SD&#59; BB&#58; beta-blocker&#59; CABG&#58; coronary artery bypass grafting&#59; CAD&#58; coronary artery disease patients&#59; CG&#58; control group&#59; CR&#58; cardiac rehabilitation&#59; ECG&#58; electrocardiogram&#59; EG&#58; exercise training group&#59; h&#58; hours&#59; HF&#58; high-frequency power&#59; HR&#58; heart rate&#59; LF&#58; low-frequency power&#59; LF&#47;HF&#58; ratio between low-frequency and high-frequency power&#59; ln&#58; natural logarithm&#59; MET&#58; metabolic equivalent&#59; MI&#58; myocardial infarction&#59; NN50&#58; number of successive NN intervals differing by &#62;50 ms&#59; nu&#58; normalized units&#59; pNN50&#58; percentage of successive NN intervals differing by &#62;50 ms&#59; post-MI&#58; patients post-myocardial infarction&#59; PTCA&#58; percutaneous transluminal coronary angioplasty&#59; RCT&#58; randomized controlled trial&#59; RMS&#58; root-mean-square residuals of the linear regression of R-R intervals&#59; RMSSD&#58; square root of the mean of the squared differences between successive NN intervals&#59; SDANN&#58; standard deviation of the average NN intervals calculated from 5-min segments&#59; SDNN index&#58; mean of the standard deviation of all normal RR intervals for all 5-min segments&#59; SDNN or SDRR&#58; standard deviation of all NN or RR intervals&#59; TP&#58; total power&#59; VLF&#58; very low-frequency power&#59; wk&#58; week&#59; wks&#58; weeks&#59; &#8592;&#8594;&#58; no significant differences from baseline&#59; &#8593;&#58; significant increase from baseline &#40;specified when the difference is also significant between groups&#41;&#59; &#8595;&#58; significant decrease from baseline &#40;specified when the difference is also significant compared to a group&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Randomized&#47;controlled&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Population&#40;sample size&#59; age in years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">HRV evaluation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Rehabilitation program&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">HRV results&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Comments&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Laing et al&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">69</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CAD &#40;n&#61;17&#59; 56&#177;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;5 min&#44; supine resting&#41; and during exercise recovery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not reported&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8592;&#8594; RMSSD&#44; RMS &#40;rest&#41;&#8593; RMSSD&#44; RMS &#40;during exercise recovery&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No report of infarct locationDaily physical activity and diet not assessedOnly 6 patients completed the post rehabilitation testing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sandercock et al&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">70</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not randomized&#59; control group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-MI&#44; PTCA&#44; CABGEG &#40;n&#61;38&#59; 65&#46;6&#177;11&#46;6&#41;CG &#40;n&#61;23&#59; 64&#46;9&#177;9&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;5 min&#44; supine resting&#41; at &#8776;16 wks post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 8 wks&#59; &#8776;1&#46;5 h of aerobic exercises&#59; &#8776;70&#37; max HRCG&#58; no specific exercise guidelines provided&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; RR interval&#44; SDNN&#44; LF &#40;ln&#41;&#44; HF &#40;ln&#41; &#40;vs&#46; CG&#41;&#8592;&#8594; RMSSD&#44; LF&#47;HF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No report of infarct locationDaily physical activity assessed by exercise diary &#40;CG only&#41;Diet not assessedCG&#58; HRV measures were more severely attenuated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tsai et al&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">After PTCA &#40;post-MI&#41;EG &#40;n&#61;42&#59; 57&#46;0&#177;8&#46;3&#41;CG &#40;n&#61;42&#59; 56&#46;7&#177;9&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;5 min&#44; supine resting&#41; at &#8776;1 month after PTCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 8 wks&#59; cycle ergometer at 60&#8211;85&#37; HR reserve&#59; 40 min&#47;session&#59; 1&#8211;3 sessions&#47;wkandhome program&#58; aerobic exercise &#40;bicycling&#44; walking&#44; or jogging&#41;&#59; similar intensityCG&#58; usual daily activities without restriction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; HF &#40;ln&#41;&#44; mean of RR intervals &#40;vs&#46; CG&#41;CG&#58; &#8595; mean of RR intervals&#44; HF &#40;ln&#41; &#40;vs&#46; EG&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No report of infarct locationDaily physical activity assessed by questionnaire interviewDiet not assessed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lucini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">71</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not randomized&#59; control group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-MI&#44; PTCA&#44; CABGEG &#40;n&#61;29&#59; 63&#177;1&#46;97&#41;CG &#40;n&#61;11&#59; 53&#177;2&#46;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;10 min&#44; supine resting&#44; respiratory signal monitored&#41; at 3&#8211;6 wks post-event&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 12 wks&#59; 30&#8211;40 min of continuous upright aerobic and dynamic exercise&#59; &#8776;70&#8211;85&#37; max HRCG&#58; usual daily activities without restriction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; RR interval variance &#40;vs&#46; CG&#41;&#8593; RR interval &#40;not different from CG&#41;&#8592;&#8594; LF &#40;nu&#41;&#44; HF &#40;nu&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No report of infarct locationDaily physical activity and diet not assessedCG&#58; younger&#44; heavier&#44; higher levels of total cholesterol&#44; HDL and LDL than EGEG and CG&#58; Encouraged to exercise 1&#8211;3 times per week outside of the rehabilitation program&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tygesen et al&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">72</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomized&#59; no control group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-MI&#59; CABG Normal-intensity group &#40;n&#61;33&#59; 56&#46;5&#177;7&#46;7&#41;High-intensity group &#40;n&#61;29&#59; 57&#46;5&#177;8&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;10 min&#44; supine resting&#44; 15 respirations&#47;min&#41; and 24-h Holter recording at 1 month post-event&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 wks&#59; cycle ergometerNormal intensity training &#40;2&#215;&#47;wk&#44; 1 h&#41;High intensity &#40;3&#215;&#47;wk&#44; 1 h &#43; 3&#215;&#47;wk&#44; 30 min&#44; at home&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593; SDNN&#44; SDANN &#40;greater in the high intensity group&#41;&#8592;&#8594; RMSSD&#44; HF&#44; LF &#40;both groups&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedOne year later exercise capacity remained at the same level in the high intensity group and there was only an insignificant trend toward increased maximal workload in the normal intensity group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Duru et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-MIEG &#40;n&#61;12&#59; 56&#177;5&#41;CG &#40;n&#61;13&#59; 55&#177;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;15 min&#44; supine resting&#41; at &#8776;1 month post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 8 wks&#59; 2&#215; outdoor walking sessions &#40;1 h&#41; daily&#59; 4 x 45-min&#47;wk &#40;cycling&#41;&#59; 70&#37; HR reserveCG&#58; usual medical care and daily living activities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">After rehabilitation&#58;EG&#58; &#8593; pNN50&#8592;&#8594; SDRR&#44; HF &#40;nu&#41;&#44; LF &#40;nu&#41;&#44; LF&#47;HFAfter 1 year&#58;CG&#58; &#8595; SDRR&#44; HF &#40;nu&#41;None of the HRV indices were significantly different between the two groups&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedHRV evaluated before and after 1 and 2 months of training and at 12 monthsCG&#58; received usual clinical follow-up&#44; and encouraged not to exercise beyond a level associated with normal activities of daily living&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Iellamo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CAD&#44; Post-MI&#44; CABGEG &#40;n&#61;45&#59; 59&#46;4&#177;7&#46;8&#41;CG &#40;n&#61;41&#59; 58&#46;5&#177;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;10 min&#44; supine resting&#41; at 2 wks after CABG and at 2 months to 9 years post-MI &#40;66&#37; in the last year before the study&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 2 wks&#59; 2&#215;&#47;day&#59; 30 min of cycle ergometer&#59; 6&#215;&#47;wk&#59; 85&#37; max HRCG&#58; walking and calisthenics with the same daily schedule as EG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; RR interval&#44; SDRR &#40;vs&#46; CG&#41;EG&#58; &#8593; RR interval&#44; SDRR &#40;both MI and non-MI patients&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedAll patients resided at the rehabilitation center for 3 weeksEG&#58; significant increase in peak VO<span class="elsevierStyleInf">2</span>CG&#58; small significant increase in peak VO<span class="elsevierStyleInf">2</span>Half of the patients in each group were post-MI &#40;stratified analysis showed no significant difference in baseline HRV between post-MI and non-MI patients&#41;Considerable variability in time between MI and baseline evaluation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pardo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">73</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CAD&#44; Post-MI&#44; CABG&#44; angina&#44; angioplasty &#40;n&#61;20&#59; 71&#177;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24-h Holter ECG recording at &#8776;40 days post-event&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 wks&#59; 3&#215;&#47;wk&#59; 50&#8211;75&#37; HR reserve&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Entire sample&#58;&#8593; HF &#40;ln&#41;&#8592;&#8594; Mean NN&#44; SDNN&#44; SDANN index&#44; SDNN index&#44; RMSSD&#44; pNN50&#44; total power&#44; LF &#40;ln&#41;After stratification by tertiles of MET and adjustment for baseline differences in resting systolic blood pressure and exercise duration&#58;&#8593; HF &#40;ln&#41;&#44; SDNN in the highest MET increase tercile&#8592;&#8594; Mean NN&#44; SDANN index&#44; SDNN index&#44; RMSSD&#44; pNN50&#44; total power&#44; LF &#40;ln&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No report of infarct locationDaily physical activity assessed by questionnaireDiet not assessedDifferent exercise intensities used&#58; 50&#8211;75&#37; HR reserve&#44; below the ischemic threshold &#40;observed during exercise stress testing&#41;&#44; and 20&#8211;30 bpm above resting HR &#40;patients who had not undergone stress testing at program entry&#41;68&#37; of patients increased their kilocalorie expenditure by exercise training and daily physical activity over the 12-week periodExercise training significantly improved HRV in cardiac patients&#44; particularly among those who achieved a threshold of &#62;1&#46;5 training METs increase over a 12-week period&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Takeyama et al&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-MI&#44; anginaEG &#40;n&#61;13&#59; 58&#46;8&#177;6&#46;3&#41;CG &#40;n&#61;15&#59; 61&#46;7&#177;8&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;3 min&#44; supine resting&#41; and during aerobic exercise at 1 wk&#44; 3 wks&#59; 3&#44; 6 and 12 months after CABG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 2 wks&#59; 2&#215; daily&#59; 30 min of cycle ergometer at anaerobic thresholdCG&#58; 1st wk&#59; 3&#215; daily&#59; 200 m-walking and 2nd wk&#44; 500 m-walking&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593; HF at rest in both groups &#40;3&#44; 6 and 12 months&#41;EG&#58; &#8593; HF during exercise at 20 W vs&#46; CG &#40;3rd wk&#59; 3rd&#44; 6th and 12th months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No report of infarct locationDaily physical activity and diet not assessedPatients using beta-blockers excluded&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Stahle et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CAD&#44; PTCA&#44; post-MI&#44; CABG&#44; anginaEG &#40;n&#61;29&#59; 71&#177;4&#41;CG &#40;n&#61;36&#59; 72&#177;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24-h Holter ECG recording at 6 wks post-event&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 3 months&#59; 3&#215;&#47;wk&#59; 50 min&#59; 3 &#215; 4 min at &#62;85&#37; max HREG and CG&#58; recommended to take a daily walk at a comfortable speed&#44; and to increase the time&#44; length and speed of the walk gradually&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; SDNN&#44; SDANN &#40;daytime&#59; vs&#46; CG&#41;&#8592;&#8594; RMSSD&#44; ULF&#44; VLF&#44; LF&#44; HF &#40;both groups&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No report of infarct locationDaily physical activity and diet not assessed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Oya et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-MIEG &#40;n&#61;16&#59; 59&#177;7&#41;CG &#40;n&#61;12&#59; 58&#177;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;3 min&#44; supine resting&#41; and during warm-up and aerobic exercise at 1 wk&#44; 3 wks and 3 months post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 2 wks&#59; 2&#215; daily&#59; 30 min of cycle ergometer at anaerobic thresholdCG&#58; walking according to conventional rehabilitation protocol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; HF during exercise at 20 W vs&#46; CG &#40;3rd wk&#41;Delta value of HF at 20 W from 1 to 3 weeks post-AMI was significantly higher in EG &#40;30&#177;6 ms<span class="elsevierStyleSup">2</span>&#41; vs&#46; CG &#40;10&#177;8 ms<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fujimoto et al&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">First uncomplicated MIEG &#40;n&#61;20&#41;CG &#40;n&#61;20&#41;Total59&#177;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24-h Holter ECG recording at 2 wks post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2wks&#59; 2&#215; daily&#59; 10 min of cycle ergometer at 80&#37; of the anaerobic threshold &#43; conventional cardiac rehabilitation program &#40;daily living activities&#41;Control group&#58; conventional cardiac rehabilitation program &#40;daily living activities&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; SDNN&#44; SDANN&#44; HF &#40;vs&#46; control group&#41;&#8595; LF&#47;HF &#40;vs&#46; control group&#41;&#8592;&#8594; mean NN&#44; SDNN index&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Malfatto et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">First uncomplicated MICR group &#40;n&#61;19&#59; 52&#177;2&#41;BB &#43; CR group &#40;n&#61;20&#59; 53&#177;2&#41;BB group &#40;n&#61;14&#59; 53&#177;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;15&#8211;20 min&#44; supine resting&#41; at 4 wks post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 wks&#59; 5&#215;&#47;wk&#59; 1 h&#59; cycle ergometer &#40;80&#37; max HR&#41; and calisthenicsAfter 8 wk&#58; regular physical exercise at home&#44; at least 2&#8211;3&#215;&#47;wk&#59;Compliance with the exercise schedule was assessed with a questionnaire during three-month follow-up phone calls&#44; and at the end&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">After 3 months of MICR group&#58; &#8592;&#8594; SDRR&#8593; MSSD&#44; pNN50&#44; HF &#40;nu&#41;&#8595; LF &#40;nu&#41;&#44; LF&#47;HFBB &#43; CR group&#58; &#8593; SDRR&#44; MSSD&#44; pNN50&#44; HF &#40;nu&#41;&#8595; LF &#40;nu&#41;&#44; LF&#47;HFBB group&#58; &#8592;&#8594; SDRR&#44; MSSD&#44; pNN50&#44; HF &#40;nu&#41;&#44; LF &#40;nu&#41;&#44; LF&#47;HF &#40;BB group&#41;One year after MI&#58;effects maintained&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedCR group&#58; MSSD increased by 25&#37; and pNN50 by 69&#37;&#44; LF&#47;HF decreased by 40&#37;BB &#43; CR group&#58; MSSD increased by 41&#37;&#44; pNN50 by 48&#37;&#44; and LF&#47;HF decreased by 39&#37;These results indicate that the effects of CR and BB on HRV are additive and not redundantOne year after MI only some patients were revaluated &#40;CR group&#58; n&#61;16&#59; BB &#43; CR group&#58; n&#61;15&#44; and BB group&#58; n&#61;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Leitch et al&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Uncomplicated MIEG &#40;n&#61;26&#59; 56&#177;1&#41;CG &#40;n&#61;23&#59; 59&#177;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24-h Holter ECG recording at 5&#8211;7 days post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 6 wks&#59; supervised hospital-based exercise training program &#40;leg ergometry and circuit training&#41;&#59; &#8776;70&#37; max HR&#59; 3&#8211;4&#215;&#47;wk&#59; 30 min &#40;1st wk&#41; to 60 min &#40;3rd to last wk&#41;&#59;&#43;Unsupervised low-intensity home walking program &#40;gradual increase in daily walking from 5 min&#44; 2&#215;&#47;day &#91;1st wk&#93; to 30 min&#44; 2&#215;&#47;day &#91;6th wk&#93;&#41;CG&#58; only unsupervised low-intensity home walking program&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; SDNN&#44; SDANN&#44; total power&#44; LF &#40;ln&#41;&#44; HF &#40;ln&#41; &#40;no significant differences between groups&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Significant differences between groups at baseline &#40;CG&#58; total power and LF were significantly reduced compared to EG&#41;Daily physical activity and diet not assessedControl group not sedentary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bryniarski et al&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">74</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">First uncomplicated MIHypertensive group &#40;n&#61;34&#59; 52&#177;9&#46;4&#41;Normotensive group &#40;n&#61;30&#59; 53&#177;9&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24-h Holter ECG recording at 14 days post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 wks&#59; 5&#215;&#47;wk&#59; gymnastics &#40;2&#215;&#47;day&#44; 20 min&#41;&#44; cycling &#40;3&#215;&#47;wk&#44; 30&#8211;45 min&#44; 60&#8211;80&#37; max HR&#41;&#44; jogging &#40;2&#215;&#47;wk&#44; 1&#46;5 km and 100 m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593; SDNN&#44; SDANN&#44; SDNNi&#44; RMSSD&#44; pNN50 &#40;both groups&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedIncrease in exercise duration and working capacity &#40;both groups&#41;All medications known to influence autonomic function had been withdrawn &#62;72 h before the study&#44; except for short-acting nitrates for relief of anginal pain if necessary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Malfatto et al&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not randomized&#59; control group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">First uncomplicated MIEG &#40;n&#61;22&#59; 52&#177;7&#41;CG &#40;n&#61;8&#59; 53&#177;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;15&#8211;20 min&#44; supine resting&#41; at 4 wks post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 8 wks&#59; 5&#215;&#47;wk&#59; 1 h&#59; cycle ergometer &#40;80&#37; max HR&#41; and calisthenicsAfter 8 wks&#58; regular physical exercise at home&#44; at least 2&#8211;3&#215;&#47;wk&#59;Compliance with the exercise schedule was assessed with a questionnaire during three-month follow-up phone calls&#44; and at the end&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 months after MIEG&#58; &#8593; SDRR&#44; MSSD&#44; pNN50&#44; HF &#40;nu&#41; &#40;vs&#46; CG&#41;&#8595; LF &#40;nu&#41;&#44; LF&#47;HF &#40;vs&#46; CG&#41;&#8593; Mean RROne year after MI&#58;effects maintained&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedOne year after MI&#44; follow-up was completed by 18 patients &#40;12 in EG and 6 in CG&#41;&#59;One year after MI only some patients were revaluated &#40;EG&#58; n&#61;12&#59; CG&#58; n&#61;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mazzuero et al&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-MIEG &#40;n&#61;22&#41;CG &#40;n&#61;16&#41;Total50&#177;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24-h Holter ECG recording at 4&#8211;6 wks post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 6 months&#59; 3&#215;&#47;wk&#59; 30 min&#59; cycle ergometer&#59; 80&#37; peak HR&#59;CG&#58; free lifestyle of their choice&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; Mean RR&#44; SDRR&#8592;&#8594; pNN50&#8593; LF&#47;HFNone of the HRV indices were significant different between the EG and CG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedCG&#58; told to avoid any strenuous physical activityDrug wash-outSome patients had a very low ejection fraction &#40;heart failure&#63;&#41;Ranges of HF and LF frequencies different from other studies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">La Rovere et al&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">First uncomplicated MITotal &#40;n&#61;22&#41;EG 47&#177;6CG 54&#177;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;15 min&#44; supine resting&#59; 15 min tilt test&#41; and 24-h Holter ECG recording at 4 wks post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 4 wks&#44; calisthenics and cycle ergometer&#59; 75&#8211;95&#37; anaerobic threshold&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8592;&#8594; HF &#40;nu&#41;&#44; LF &#40;nu&#41;&#44; LF&#47;HFEG &#40;tilt test&#41;&#58; &#8593; LF&#59; &#8595; HF&#59;&#8593; LF&#47;HF &#40;vs&#46; CG&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedDrug wash-outEG&#58; improved response to the tilt test&#44; suggesting improvement in the reflex activity of the autonomic nervous system&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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Review article
Heart rate variability in myocardial infarction patients: Effects of exercise training
Variabilidade da frequência cardíaca em pacientes após enfarte do miocárdio: efeitos do exercício físico regular
Nórton Luís Oliveiraa,
Corresponding author
nloedfisica@gmail.com

Corresponding author.
, Fernando Ribeiroa,b, Alberto Jorge Alvesa, Madalena Teixeirac, Fátima Mirandad, José Oliveiraa
a Research Center in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal
b CESPU, Polytechnic Health Institute of the North, Gandra PRD, Portugal
c Cardiology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal
d Physical Medicine and Rehabilitation Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introduction</span><p id="par0090" class="elsevierStylePara elsevierViewall">Cardiovascular disease &#40;CVD&#41; is the leading cause of death worldwide&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> According to the Global Atlas on Cardiovascular Disease Prevention and Control published by the World Health Organization&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> of the 57 million deaths that occurred globally in 2008&#44; 17&#46;3 million &#40;30&#37;&#41; were due to CVD&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">A common element in CVD&#44; including myocardial infarction &#40;MI&#41;&#44; is a detrimental change in cardiac autonomic modulation&#44; i&#46;e&#46;&#44; increased sympathetic outflow and reduced parasympathetic activity&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Cardiac autonomic modulation refers to the influence that these two branches of the autonomic nervous system have on the heart&#58; they interact in a complex way to regulate the heart&#39;s chronotropism&#44; dromotropism&#44; and inotropism&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Soon after MI&#44; autonomic imbalance acts to preserve the proper functioning of the cardiovascular system and consequently of the whole body&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Nevertheless&#44; the maintenance of this imbalance can lead to harmful consequences in MI patients&#44; such as decreased cardiomyocyte viability due to the cytotoxic effect of elevated catecholamine levels<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> and adverse cardiac remodeling&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;8</span></a> Simultaneously&#44; myocardial overload&#44; due to the elevated heart rate &#40;HR&#41; and contractility induced by sympathetic overactivity&#44; increases oxygen demand and reduces coronary perfusion time&#44; impairing coronary blood flow in the weakened myocardium and thereby increasing the likelihood of ischemic insult and malignant ventricular arrhythmias and hence the risk of sudden cardiac death&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">A relatively easy noninvasive method that is reproducible and cost-effective for estimating cardiac autonomic modulation is evaluation of heart rate variability &#40;HRV&#41;&#44; which analyzes variations in the intervals between consecutive normal heart beats or normal R wave peaks &#40;i&#46;e&#46;&#44; RR or NN intervals&#41;&#44; measured in ms&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;11</span></a> Depressed HRV suggests poor functioning of cardiac autonomic modulation and therefore impaired ability of the heart to adapt to a range of physiological and environmental stimuli&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Various HRV indices have been used to stratify the risk of mortality and cardiovascular events in patients after MI&#44; and have shown promising results&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#8211;15</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Recommendations to join exercise training programs and to increase daily physical activity levels are included in the guidelines for secondary prevention through cardiac rehabilitation in patients with documented coronary artery disease &#40;CAD&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;17</span></a> Exercise-based cardiac rehabilitation has been shown to be an effective therapy for reducing mortality and morbidity in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> There are many documented benefits arising from exercise training&#44; such as improvements in aerobic fitness&#44; exercise capacity&#44; ventilatory threshold&#44; modifiable cardiovascular disease risk factors&#44; endothelial function&#44; and vascular wall inflammation&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#8211;21</span></a> The effect of exercise-based cardiac rehabilitation on the impaired autonomic function of CAD patients has also been studied&#44;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#8211;24</span></a> although there are conflicting results regarding the impact of exercise training on HRV&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">This review aims to provide a critical appraisal of the literature linking exercise training and autonomic function in MI patients and a discussion of the possible mechanisms underlying the effects of exercise training on autonomic function&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Heart rate variability indices and prognostic implications</span><p id="par0115" class="elsevierStylePara elsevierViewall">It is not the main purpose of the present review to describe the HRV indices employed in the literature&#59; this has been done in detail by Malik et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and Kleiger et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> However&#44; it is important to mention that traditional methods&#44; based on time and frequency domains&#44; are by far the most commonly used&#46; The main time domain indices include the standard deviation of all NN intervals &#40;SDNN&#41;&#44; the standard deviation of average NN intervals calculated from 5-minute segments &#40;SDANN&#41;&#44; the square root of the mean of the squared differences between successive NN intervals &#40;RMSSD&#41;&#44; and the percentage of successive NN intervals differing by &#62;50 ms &#40;pNN50&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;11</span></a> Frequency domain indices include low-frequency &#40;LF&#41; peak &#40;0&#46;04&#8211;0&#46;15 Hz&#41;&#44; high-frequency peak &#40;0&#46;15&#8211;0&#46;4 Hz&#41;&#44; expressed in absolute units of power &#40;ms<span class="elsevierStyleSup">2</span>&#41; or in normalized units &#40;nu&#41;&#44; and the ratio between them &#40;LF&#47;HF&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;11</span></a> It is widely accepted that in general&#44; time domain variables are related to each other and are affected to different degrees by parasympathetic blockade&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> Recent evidence supports the idea that they are markers of parasympathetic cardiac modulation&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> Nevertheless&#44; HF peak is established as the foremost HRV marker of efferent cardiac vagal activity &#40;i&#46;e&#46;&#44; vagal modulation of HR&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> There is no consensus regarding interpretation of the LF component&#44; but it is considered a marker of both sympathetic and parasympathetic modulation&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> Lastly&#44; the LF&#47;HF ratio has been reported as a measure of sympathovagal balance&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Various studies have been conducted to investigate the prognostic value of HRV after acute MI&#44; employing&#58; &#40;i&#41; different methods to analyze HRV data &#40;e&#46;g&#46;&#44; traditional&#44; geometric&#44; and nonlinear&#41;&#44; &#40;ii&#41; different periods of time after MI to evaluate baseline HRV &#40;from days to weeks or months&#41;&#44; &#40;iii&#41; different follow-up periods &#40;from months to years&#41;&#44; and &#40;iv&#41; different end-points &#40;e&#46;g&#46;&#44; arrhythmic events&#44; cardiac death&#44; sudden death&#44; and all-cause mortality&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#8211;15</span></a> Kleiger et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> in an elegant study&#44; evaluated HRV with 24-hour Holter ECG monitoring in 808 patients recovering from MI &#40;11&#177;3 days after the acute event&#41;&#44; and observed a relative risk of all-cause mortality of 2&#46;7 for those with SDNN &#60;50 ms compared to those with SDNN &#8805;50 ms&#44; after a 31-month follow-up&#46; In addition&#44; after adjusting for measures such as ejection fraction&#44; exercise capacity&#44; post-infarction angina&#44; ventricular arrhythmias&#44; and drug treatment&#44; SDNN was established as an independent predictor of mortality&#46; La Rovere et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> in the Autonomic Tone and Reflexes After Myocardial Infarction &#40;ATRAMI&#41; study&#44; assessed 24-hour Holter HRV in a representative sample of recent &#40;&#60;28 days&#41; post-MI patients &#40;n&#61;1284&#41;&#44; of whom 63&#37; received thrombolytic therapy&#46; Over a mean follow-up of 21&#177;8 months&#44; it was observed that both one- and two-year cardiac mortality were higher among patients with SDNN &#60;70 ms&#46; In addition&#44; Bigger et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> evaluating LF and HF among other frequency domain indices&#44; found that reduced levels of all measures were predictors of arrhythmic&#44; all-cause&#44; and cardiac mortality over a follow-up of two to four years&#46; To summarize&#44; these findings show that various HRV indices can provide valuable prognostic information on MI patients&#46; However&#44; for the purpose of dichotomous risk stratification in clinical practice&#44; diverse HRV cut-off points have been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> For instance&#44; Kleiger et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> applied a cut-off of SDNN &#60;50 ms&#44; while in the ATRAMI study<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> the cut-off was defined as SDNN &#60;70 ms to differentiate MI patients with impaired HRV and consequently increased risk of developing the assessed end-points&#46; Besides the conflicting results&#44; the establishment of a single cut-off point did not allow normal HRV values to be distinguished from moderately and severely abnormal HRV values&#46; This was the aim of Milicevic et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> who analyzed various HRV indices in cardiac inpatient and outpatient groups&#46; For the entire sample&#44; the range of moderately depressed SDNN values was 59&#8211;92 ms&#44; with values above these limits being considered normal&#44; and below severely depressed&#46; On the other hand&#44; different values were expressed when the sample analysis was performed by gender and group&#46; For outpatients&#44; a moderately depressed SDNN was 75&#8211;105 ms for females and 65&#8211;100 ms for males&#46; For inpatients attending a rehabilitation program&#44; a moderately depressed SDNN was 47&#8211;74 ms for females and 53&#8211;83 ms for males&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">There are numerous reasons for the considerable variability in the ranges of SDNN and other HRV indices&#58; differences in infarct location and size&#44; differences in age&#44; gender&#44; and experimental conditions&#44; and difference in the statistical approach for data analysis&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4</span></a> In view of this variety&#44; dichotomized cut-off points or ranges to define normal&#44; moderately abnormal&#44; and severely abnormal HRV values have not been universally accepted&#44; and further investigation and debate are thus warranted on this issue&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Effects of exercise training on heart rate variability in myocardial infarction patients</span><p id="par0130" class="elsevierStylePara elsevierViewall">Exercise-based cardiac rehabilitation has been shown to provide various health-related benefits&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> including improvements in exercise tolerance&#44; endothelial function&#44; cardiovascular risk factors&#44; and vascular wall inflammation&#44; which can collectively reduce morbidity and mortality in CAD patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;21&#44;29&#44;30</span></a> A meta-analysis of 47 studies randomizing 10<span class="elsevierStyleHsp" style=""></span>794 CAD patients to exercise-based cardiac rehabilitation or usual care found significant reductions in total mortality &#40;13&#37;&#41;&#44; cardiac mortality &#40;26&#37;&#41;&#44; and hospital admissions &#40;31&#37;&#41; in patients who exercised in a mean follow-up of 12 months or more&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> Furthermore&#44; a significant reduction in sudden cardiac death &#40;37&#37;&#41; was also observed in CAD patients participating in exercise training compared to usual medical care&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">As reduced HRV in CAD patients is associated with increased risk of all-cause mortality&#44; cardiac mortality&#44; and sudden death&#44; one possible explanation for the reduction in morbidity and mortality in patients undergoing exercise-based cardiac rehabilitation could be exercise-induced improvement in cardiac autonomic modulation&#46; However&#44; no prospective study has been performed to test this hypothesis&#46; Studies in healthy trained subjects undergoing aerobic exercise training<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">31&#8211;33</span></a> have shown increased vagal and&#47;or reduced sympathetic cardiac modulation&#44; characterized by resting bradycardia and increased vagal-related HRV indices&#44; compared to sedentary controls&#46; Regarding the effects of exercise-based cardiac rehabilitation on HRV indices &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#44; data from studies on post-MI patients have revealed heterogeneous results&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#8211;24&#44;34&#8211;42</span></a> However&#44; not all of these studies were randomized controlled trials&#44; which to some extent weakens their conclusions&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0140" class="elsevierStylePara elsevierViewall">In a randomized controlled study&#44; Duru et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> assessed the time and frequency domain HRV &#40;short-term&#44; 30 min&#41; of 25 post-MI patients&#44; before and after an eight-week cycling&#47;walking exercise program at roughly 70&#37; of their HR reserve or on usual medical care only&#44; and found no differences in HRV indices&#46; Other studies showed similar results&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">34&#8211;36</span></a> La Rovere et al&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> also found no enhancement in frequency domain HRV indices at rest after a four-week exercise training program with calisthenics and cycle ergometer at 75&#8211;95&#37; of anaerobic threshold&#46; However&#44; the exercise-training program significantly increased LF and decreased HF in response to the head-up tilt test&#46; The fact that these responses were more marked in the trained group than in controls suggests that the reflex activity of the autonomic system may have been improved by a short-term exercise training program&#46; A study comprising a very short &#40;two weeks&#41; exercise training program at an intensity corresponding to the anaerobic threshold also showed no significant effect on the HF component of HRV at rest&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> Nevertheless&#44; during a constant load exercise test &#40;20 W&#41;&#44; a significant increase in HF was observed in the trained group&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> Similar results during a constant load exercise test &#40;20 W&#41; were reported by Oya et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> who observed an HF delta value of 30&#177;6 ms<span class="elsevierStyleSup">2</span>&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Significant improvements in the HRV of the trained group compared to control groups were also reported in some randomized controlled trials&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#44;39&#8211;41</span></a> Forty patients&#44; enrolled two weeks after their first uncomplicated MI&#44; were randomly allocated to two-week exercise training on a cycle ergometer performed twice a day at an intensity of 80&#37; of their anaerobic threshold or to the control group &#40;n&#61;20&#41;&#46; Following exercise training&#44; SDNN increased significantly from 104&#46;9&#177;16&#46;3 to 121&#46;7&#177;26&#46;8 ms&#44; SDANN from 89&#46;4&#177;17&#46;4 to 106&#46;9&#177;28&#46;5 ms&#44; and HF from 82&#46;5&#177;56&#46;2 to 131&#46;1&#177;99&#46;8 ms<span class="elsevierStyleSup">2</span>&#44; while the LF&#47;HF ratio decreased from 3&#46;9&#177;2&#46;2 to 2&#46;6&#177;1&#46;3&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> Iellamo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> applied a similar exercise program in 45 patients with and without previous MI&#46; After two weeks of training&#44; the resting RR interval was increased by a significant 7&#37; and SDNN by 26&#37; in the exercise group only &#40;both MI and non-MI patients&#41;&#46; Stahle et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> also reported higher HRV values &#40;daytime SDNN and SDANN&#41; for the exercise group after a three-month training period&#46; Likewise&#44; a more recent study was conducted on a heterogeneous sample of CAD patients&#44; of whom at least half had previous MI&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> Eighty-four patients were randomly allocated to a control or exercise group and after eight weeks of exercise training&#44; the exercise group showed a 10&#37; increase in HF power and 5&#37; in the mean of RR intervals&#44; while in the control group these indices decreased&#46; Furthermore&#44; it was observed that the acute MI patients presented greater increases in HRV indices than those without acute MI&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Although not randomized&#44; two studies by Malfatto et al&#46;&#44; <a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24&#44;42</span></a> deserve mention&#44; especially regarding their design&#46; In these studies&#44; post-MI patients underwent supervised aerobic exercise five times a week for eight weeks&#46; Afterwards&#44; a non-supervised exercise schedule was prescribed to be followed for one year&#46; Compliance with this schedule was assessed by phone calls&#46; In the first study&#44;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a> SDNN&#44; RMSSD&#44; and pNN50 increased and LF&#47;HF ratio decreased in the training group after exercise training by 25&#37;&#44; 69&#37;&#44; 120&#37;&#44; and 30&#37;&#44; respectively&#46; In the second study&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> the same HRV indices improved in two of three patient groups&#44; one treated with exercise-based cardiac rehabilitation only and another with the addition of beta-blocker therapy&#46; The third group&#44; treated only with beta-blockers&#44; showed no change in HRV&#46; Moreover&#44; the higher vagal tone observed in the combined-therapy group compared to the exercise-only group suggests an additive effect with the two therapies&#46; After one year&#44; in both studies&#44; the positive effects on HRV were maintained in the groups that underwent supervised exercise and had followed the non-supervised exercise schedule&#46; The latter finding indicates a long-term beneficial effect in patients who complied with the home-based exercise schedule&#44; which was later confirmed by the same research group in a different study&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a> The beneficial effect on HRV of a home-based exercise program was suggested in a study by Leitch et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> In this study&#44; 49 patients with uncomplicated MI were randomly allocated to a six-week hospital-based exercise training program plus an unsupervised low-intensity home walking program &#40;exercise group&#41; or to a home walking program only &#40;control group&#41;&#46; The authors reported significant improvements in all HRV indices in both groups&#46; However&#44; the lack of a true control group makes it impossible to exclude the possibility that the natural recovery of HRV after the acute event could have contributed to the results&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">There may be several reasons for the conflicting results reported by the above-mentioned studies&#44; such as small sample sizes&#44; dissimilar inclusion and exclusion criteria &#40;e&#46;g&#46;&#44; patients over 70 years old&#41;&#44; mixed groups of cardiac patients &#40;acute MI vs&#46; angina&#44; coronary artery bypass grafting &#91;CABG&#93; vs&#46; percutaneous transluminal coronary angioplasty &#91;PTCA&#93;&#41;&#44; the baseline assessment being performed at different times after the acute event&#44; lack of data on infarct size and location&#44; and lack of control of potentially confounding variables such as dietary intake and daily physical activity performed by the study groups apart from the exercise training program&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;35&#44;36&#44;40&#44;44</span></a> Other possible explanations include different methods and protocols used to assess HRV&#44; such as the mathematical methods to calculate the power spectral density &#40;autoregressive and fast Fourier transform&#41;&#44; and the period used to record RR interval data&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#44;34&#44;37&#44;39&#44;45</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">Furthermore&#44; in short-term recordings of HRV&#44; a critical element in the comparison of outcomes is data on breathing frequency&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a> which was not reported in some studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23&#44;34&#44;41</span></a> In addition&#44; high baseline HRV values could limit the magnitude of changes induced by therapeutic exercise&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> Similarly&#44; a plateau or saturation point has been reported&#44; particularly in individuals with high vagal activity or with very low resting HR&#44; beyond which there is no further increase in HRV or in indices related to cardiac vagal modulation &#40;especially HF&#41; with increases in cardiac vagal activity&#59; indeed&#44; there may even be a reduction in HRV&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">47&#44;48</span></a> Thus&#44; a simple statistical analysis including these individuals together with those with low cardiac vagal activity could have underestimated the beneficial effect of exercise&#46; In these cases&#44; a stratified analysis by baseline HRV values is recommended&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Regarding studies reporting beneficial effects of exercise on HRV&#44; it is not possible to clearly ascertain which is the best combination of exercise training variables &#40;duration of the program&#44; mode of exercise&#44; intensity&#44; and frequency&#41; to enhance HRV&#46; Similar exercise training programs have provided different outcomes and&#44; in addition&#44; some studies do not provide complete information on training load variables&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;37&#8211;39&#44;41</span></a> Conversely&#44; studies with dissimilar training designs have shown significant improvements in HRV&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#44;41</span></a> On the other hand&#44; four weeks of aerobic exercise training at 75&#8211;95&#37; of anaerobic threshold did not increase HRV&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> whereas only two weeks of a similar training program were able to raise some HRV indices&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> Further studies are thus needed to examine the exercise-dose relationship required to improve HRV&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Mechanisms related to enhanced cardiac vagal modulation after exercise training</span><p id="par0170" class="elsevierStylePara elsevierViewall">Understanding of the mechanisms responsible for the therapeutic effect of exercise training on cardiac autonomic modulation and on HRV is limited&#46; Nevertheless&#44; studies on animals and humans have provided some indications&#44; including decreases in catecholamine levels&#44; beta-adrenergic receptor density and angiotensin II&#44; and increased nitric oxide &#40;NO&#41; bioavailability&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">The effects of exercise training on catecholamine levels have been studied in cardiovascular disease patients&#44; particularly in heart failure patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">49&#44;50</span></a> Coats et al&#46; found a decrease in whole-body norepinephrine spillover following exercise training&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> In another study with heart failure patients enrolled in a six-month exercise-training program&#44; resting plasma norepinephrine and epinephrine concentrations fell after training by 52&#37; and 50&#37;&#44; respectively&#44; while the control group showed no changes&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a> Even without a significant decrease in catecholamine levels&#44; exercise training can have a positive effect by reducing adrenergic receptor density&#59; a study in animal models showed that a 10-week aerobic exercise program induced a significant reduction in beta-adrenergic receptor density&#44; which was associated with bradycardia in trained animals&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">Another mechanism that could contribute to increased cardiac vagal modulation after exercise training is the increased cardiac acetylcholine content and choline acetyltransferase activity observed in the hearts of trained rats&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">A reduction in angiotensin II levels also appears to have an important influence on parasympathetic activity&#44; as this peptide has been shown to increase sympathetic outflow and reduce vagal activity&#46;<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">53&#44;54</span></a> A study using an animal model reported a significant decrease in angiotensin II levels in rats undergoing aerobic exercise training&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a> Additionally&#44; longitudinal studies have reported significant reductions in plasma renin with training&#44;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">56&#44;57</span></a> and cross-sectional studies have observed reduced plasma renin activity in runners compared to sedentary individuals&#46;<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">58&#44;59</span></a> Nevertheless&#44; a recent study in hypertensive patients indicated that aerobic exercise training improved cardiac autonomic function independently of angiotensin-converting enzyme inhibitor treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> Thus&#44; other potential mechanisms should be considered when analyzing the effects of exercise training on HRV&#44; such as increased NO bioavailability&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Findings from animal and human research have shown that NO increases vagal activity at central and peripheral sites&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">61&#8211;64</span></a> The favorable effect of exercise training on NO bioavailability may be due to increased production and&#47;or decreased degradation&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Hambrecht et al&#46; showed increased expression and phosphorylation of endothelial NO synthase in CAD patients after aerobic exercise training&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">65</span></a> There is also evidence of increased neuronal NO synthase activity after exercise training&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">66</span></a> In addition&#44; overexpression of neuronal NO synthase in rats led to a significant attenuation of the increase in renal sympathetic nerve activity mediated by angiotensin II&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a> Exercise training also reduces NO degradation by increasing antioxidant defenses&#44; particularly by increasing the activity of superoxide dismutase and glutathione peroxidase&#46;<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">67&#44;68</span></a> Exercise training thus increases NO bioavailability and this may mediate the effect of exercise on cardiac vagal activity&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="par0195" class="elsevierStylePara elsevierViewall">Current knowledge shows that post-MI patients exhibit unbalanced cardiac autonomic function&#44; with predominance of the sympathetic nervous system to the detriment of the parasympathetic system&#46; This can be manifested by reduced HRV&#44; which has been associated with increased risk of malignant ventricular arrhythmias&#44; subsequent sudden death&#44; and other cardiovascular events in these patients&#46; However&#44; cut-off or reference values for the different indices of HRV are not well established&#44; which hampers their use in clinical practice for risk and prognostic stratification&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">Despite the conflicting evidence&#44; exercise training appears to be a useful therapeutic intervention to improve the unbalanced autonomic function of MI patients&#46; Nevertheless&#44; the small number of randomized controlled trials&#44; the lack of uniformity in study designs&#44; and the lack of control of potentially confounding variables should be taken into account&#46; Furthermore&#44; from studies observing an increase in cardiac vagal activity after aerobic exercise programs&#44;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#44;39&#8211;41</span></a> it is not possible to establish the best combination of training load variables &#40;length of the exercise program&#44; exercise mode&#44; intensity&#44; frequency&#44; and duration&#41; to enhance HRV&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Finally&#44; the possible mechanisms underlying the effects of exercise on cardiac autonomic modulation are not yet well understood&#44; but some studies have shown that nitric oxide bioavailability and angiotensin II levels play an important role&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Ethical disclosures</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Protection of human and animal subjects</span><p id="par0210" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Confidentiality of data</span><p id="par0215" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Right to privacy and informed consent</span><p id="par0220" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Funding</span><p id="par0225" class="elsevierStylePara elsevierViewall">This work was funded by <span class="elsevierStyleGrantSponsor" id="gs0005">FEDER &#40;European Regional Development Fund&#41;</span> through the Operational Competitiveness Programme &#40;COMPETE&#41;&#44; and by the <span class="elsevierStyleGrantSponsor" id="gs0010">Portuguese Foundation for Science and Technology &#40;FCT&#41;</span> within the projects FCOMP-01-0124-FEDER-014706 &#40;reference&#58; FCT&#58; PTDC&#47;DES&#47;113753&#47;2009&#41; and PEst-OE&#47;SAU&#47;UI0617&#47;2011&#46; FCT has supported the authors N&#243;rton Lu&#237;s Oliveira &#40;grant no&#46; SFRH&#47;BD&#47;48875&#47;2008&#41; and Fernando Ribeiro &#40;grant no&#46; SFRH&#47;BPD&#47;69965&#47;2010&#41;&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conflicts of interests</span><p id="par0230" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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          "identificador" => "xres296962"
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          "identificador" => "xres296963"
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          "identificador" => "sec0005"
          "titulo" => "Introduction"
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        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Heart rate variability indices and prognostic implications"
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        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Effects of exercise training on heart rate variability in myocardial infarction patients"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Mechanisms related to enhanced cardiac vagal modulation after exercise training"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conclusions"
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        9 => array:3 [
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          "titulo" => "Ethical disclosures"
          "secciones" => array:3 [
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              "identificador" => "sec0035"
              "titulo" => "Protection of human and animal subjects"
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            1 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Confidentiality of data"
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            2 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Right to privacy and informed consent"
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        10 => array:2 [
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          "titulo" => "Funding"
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          "titulo" => "Conflicts of interests"
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    "fechaRecibido" => "2012-10-31"
    "fechaAceptado" => "2013-02-04"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec280627"
          "palabras" => array:4 [
            0 => "Heart rate variability"
            1 => "Autonomic function"
            2 => "Myocardial infarction"
            3 => "Exercise training"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec280628"
          "palabras" => array:4 [
            0 => "Variabilidade da frequ&#234;ncia card&#237;aca"
            1 => "Fun&#231;&#227;o auton&#243;mica"
            2 => "Enfarte do mioc&#225;rdio"
            3 => "Exerc&#237;cio"
          ]
        ]
      ]
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Heart rate variability &#40;HRV&#41; is a simple and noninvasive measure that estimates cardiac autonomic modulation&#44; mainly the parasympathetic contribution&#46; Increased sympathetic and&#47;or decreased parasympathetic nervous activity is seen in post-myocardial infarction &#40;MI&#41; patients&#46; Consequently&#44; these patients present reduced HRV&#44; which has been associated with increased risk of adverse events and mortality&#46; Exercise training&#44; recommended as a complementary therapy for patients with cardiovascular disease&#44; has shown numerous beneficial effects&#46; The main aim of the present manuscript was to provide a critical review of studies investigating the effects of exercise training on cardiac autonomic modulation&#44; through HRV&#44; in MI patients and the possible mechanisms involved&#46; Despite conflicting evidence&#44; exercise training appears to be a useful therapeutic intervention to improve the unbalanced autonomic function of MI patients&#46; Finally&#44; the mechanisms involved are not yet well understood&#44; but nitric oxide bioavailability and angiotensin II levels seem to play an important role&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A variabilidade da frequ&#234;ncia card&#237;aca &#233; uma medida simples e n&#227;o invasiva da modula&#231;&#227;o auton&#243;mica card&#237;aca&#44; principalmente da contribui&#231;&#227;o da divis&#227;o parassimp&#225;tica&#46; O aumento da atividade simp&#225;tica e&#47;ou a diminui&#231;&#227;o da atividade parassimp&#225;tica ocorre em doentes com enfarte agudo do mioc&#225;rdio&#46; Consequentemente&#44; estes doentes apresentam reduzida variabilidade da frequ&#234;ncia card&#237;aca&#44; a qual tem sido associada com risco aumentado de eventos card&#237;acos adversos e de mortalidade&#46; Existem evid&#234;ncias de numerosos benef&#237;cios do exerc&#237;cio f&#237;sico regular&#44; quando recomendado como terap&#234;utica coadjuvante em sujeitos com doen&#231;a cardiovascular&#46; Assim sendo&#44; o prop&#243;sito do presente artigo &#233; a realiza&#231;&#227;o de uma revis&#227;o cr&#237;tica dos estudos investigando o efeito do exerc&#237;cio f&#237;sico regular na variabilidade da frequ&#234;ncia card&#237;aca e os potenciais mecanismos em doentes com hist&#243;ria de enfarte agudo do mioc&#225;rdio&#46; O exerc&#237;cio f&#237;sico regular parece ser um meio terap&#234;utico para melhorar a desregula&#231;&#227;o da fun&#231;&#227;o do sistema nervoso aut&#243;nomo em doentes com hist&#243;ria de enfarte agudo do mioc&#225;rdio&#44; apesar de os resultados contradit&#243;rios entre os estudos&#46; Finalmente&#44; n&#227;o est&#227;o claramente estabelecidos os poss&#237;veis mecanismos pelos quais o exerc&#237;cio melhora a variabilidade da frequ&#234;ncia card&#237;aca&#44; mas o aumento da biodisponibilidade do &#243;xido n&#237;trico e a redu&#231;&#227;o dos n&#237;veis de angiotensina II induzidos pelo exerc&#237;cio parecem desempenhar um importante papel&#46;</p>"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Oliveira NL&#44; Ribeiro F&#44; Alves AJ&#44; Teixeira M&#44; Miranda F&#44; Oliveira J&#46; Variabilidade da frequ&#234;ncia card&#237;aca em pacientes ap&#243;s enfarte do mioc&#225;rdio&#58; efeitos do exerc&#237;cio f&#237;sico regular 2012&#46; http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;&#46;</p>"
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    ]
    "nomenclatura" => array:1 [
      0 => array:3 [
        "identificador" => "nom0005"
        "titulo" => "<span class="elsevierStyleSectionTitle" id="sect0025">List of abbreviations</span>"
        "listaDefinicion" => array:1 [
          0 => array:1 [
            "definicion" => array:17 [
              0 => array:2 [
                "termino" => "ATRAMI"
                "descripcion" => "<p id="par0005" class="elsevierStylePara elsevierViewall">Autonomic Tone and Reflexes After Myocardial Infarction study</p>"
              ]
              1 => array:2 [
                "termino" => "CABG"
                "descripcion" => "<p id="par0010" class="elsevierStylePara elsevierViewall">coronary artery bypass grafting</p>"
              ]
              2 => array:2 [
                "termino" => "CAD"
                "descripcion" => "<p id="par0015" class="elsevierStylePara elsevierViewall">coronary artery disease</p>"
              ]
              3 => array:2 [
                "termino" => "CVD"
                "descripcion" => "<p id="par0020" class="elsevierStylePara elsevierViewall">cardiovascular disease</p>"
              ]
              4 => array:2 [
                "termino" => "HF"
                "descripcion" => "<p id="par0025" class="elsevierStylePara elsevierViewall">high-frequency peak</p>"
              ]
              5 => array:2 [
                "termino" => "HR"
                "descripcion" => "<p id="par0030" class="elsevierStylePara elsevierViewall">heart rate</p>"
              ]
              6 => array:2 [
                "termino" => "HRV"
                "descripcion" => "<p id="par0035" class="elsevierStylePara elsevierViewall">heart rate variability</p>"
              ]
              7 => array:2 [
                "termino" => "LF"
                "descripcion" => "<p id="par0040" class="elsevierStylePara elsevierViewall">low-frequency peak</p>"
              ]
              8 => array:2 [
                "termino" => "LF&#47;HF"
                "descripcion" => "<p id="par0045" class="elsevierStylePara elsevierViewall">ratio between low-frequency and high-frequency peak</p>"
              ]
              9 => array:2 [
                "termino" => "MI"
                "descripcion" => "<p id="par0050" class="elsevierStylePara elsevierViewall">myocardial infarction</p>"
              ]
              10 => array:2 [
                "termino" => "NN or RR intervals"
                "descripcion" => "<p id="par0055" class="elsevierStylePara elsevierViewall">intervals between consecutive normal heart beats or normal R wave peaks</p>"
              ]
              11 => array:2 [
                "termino" => "NO"
                "descripcion" => "<p id="par0060" class="elsevierStylePara elsevierViewall">nitric oxide</p>"
              ]
              12 => array:2 [
                "termino" => "pNN50"
                "descripcion" => "<p id="par0065" class="elsevierStylePara elsevierViewall">percentage of successive NN intervals differing by &#62;50 ms</p>"
              ]
              13 => array:2 [
                "termino" => "PTCA"
                "descripcion" => "<p id="par0070" class="elsevierStylePara elsevierViewall">percutaneous transluminal coronary angioplasty</p>"
              ]
              14 => array:2 [
                "termino" => "RMSSD"
                "descripcion" => "<p id="par0075" class="elsevierStylePara elsevierViewall">square root of the mean of the squared differences between successive NN intervals</p>"
              ]
              15 => array:2 [
                "termino" => "SDANN"
                "descripcion" => "<p id="par0080" class="elsevierStylePara elsevierViewall">standard deviation of average NN intervals calculated from 5-minute segments</p>"
              ]
              16 => array:2 [
                "termino" => "SDNN"
                "descripcion" => "<p id="par0085" class="elsevierStylePara elsevierViewall">standard deviation of all NN intervals</p>"
              ]
            ]
          ]
        ]
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Age&#58; mean &#177; SD&#59; BB&#58; beta-blocker&#59; CABG&#58; coronary artery bypass grafting&#59; CAD&#58; coronary artery disease patients&#59; CG&#58; control group&#59; CR&#58; cardiac rehabilitation&#59; ECG&#58; electrocardiogram&#59; EG&#58; exercise training group&#59; h&#58; hours&#59; HF&#58; high-frequency power&#59; HR&#58; heart rate&#59; LF&#58; low-frequency power&#59; LF&#47;HF&#58; ratio between low-frequency and high-frequency power&#59; ln&#58; natural logarithm&#59; MET&#58; metabolic equivalent&#59; MI&#58; myocardial infarction&#59; NN50&#58; number of successive NN intervals differing by &#62;50 ms&#59; nu&#58; normalized units&#59; pNN50&#58; percentage of successive NN intervals differing by &#62;50 ms&#59; post-MI&#58; patients post-myocardial infarction&#59; PTCA&#58; percutaneous transluminal coronary angioplasty&#59; RCT&#58; randomized controlled trial&#59; RMS&#58; root-mean-square residuals of the linear regression of R-R intervals&#59; RMSSD&#58; square root of the mean of the squared differences between successive NN intervals&#59; SDANN&#58; standard deviation of the average NN intervals calculated from 5-min segments&#59; SDNN index&#58; mean of the standard deviation of all normal RR intervals for all 5-min segments&#59; SDNN or SDRR&#58; standard deviation of all NN or RR intervals&#59; TP&#58; total power&#59; VLF&#58; very low-frequency power&#59; wk&#58; week&#59; wks&#58; weeks&#59; &#8592;&#8594;&#58; no significant differences from baseline&#59; &#8593;&#58; significant increase from baseline &#40;specified when the difference is also significant between groups&#41;&#59; &#8595;&#58; significant decrease from baseline &#40;specified when the difference is also significant compared to a group&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Randomized&#47;controlled&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Population&#40;sample size&#59; age in years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">HRV evaluation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Rehabilitation program&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">HRV results&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Comments&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Laing et al&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">69</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CAD &#40;n&#61;17&#59; 56&#177;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;5 min&#44; supine resting&#41; and during exercise recovery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not reported&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8592;&#8594; RMSSD&#44; RMS &#40;rest&#41;&#8593; RMSSD&#44; RMS &#40;during exercise recovery&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No report of infarct locationDaily physical activity and diet not assessedOnly 6 patients completed the post rehabilitation testing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sandercock et al&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">70</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not randomized&#59; control group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-MI&#44; PTCA&#44; CABGEG &#40;n&#61;38&#59; 65&#46;6&#177;11&#46;6&#41;CG &#40;n&#61;23&#59; 64&#46;9&#177;9&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;5 min&#44; supine resting&#41; at &#8776;16 wks post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 8 wks&#59; &#8776;1&#46;5 h of aerobic exercises&#59; &#8776;70&#37; max HRCG&#58; no specific exercise guidelines provided&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; RR interval&#44; SDNN&#44; LF &#40;ln&#41;&#44; HF &#40;ln&#41; &#40;vs&#46; CG&#41;&#8592;&#8594; RMSSD&#44; LF&#47;HF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No report of infarct locationDaily physical activity assessed by exercise diary &#40;CG only&#41;Diet not assessedCG&#58; HRV measures were more severely attenuated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tsai et al&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">After PTCA &#40;post-MI&#41;EG &#40;n&#61;42&#59; 57&#46;0&#177;8&#46;3&#41;CG &#40;n&#61;42&#59; 56&#46;7&#177;9&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;5 min&#44; supine resting&#41; at &#8776;1 month after PTCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 8 wks&#59; cycle ergometer at 60&#8211;85&#37; HR reserve&#59; 40 min&#47;session&#59; 1&#8211;3 sessions&#47;wkandhome program&#58; aerobic exercise &#40;bicycling&#44; walking&#44; or jogging&#41;&#59; similar intensityCG&#58; usual daily activities without restriction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; HF &#40;ln&#41;&#44; mean of RR intervals &#40;vs&#46; CG&#41;CG&#58; &#8595; mean of RR intervals&#44; HF &#40;ln&#41; &#40;vs&#46; EG&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No report of infarct locationDaily physical activity assessed by questionnaire interviewDiet not assessed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lucini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">71</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not randomized&#59; control group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-MI&#44; PTCA&#44; CABGEG &#40;n&#61;29&#59; 63&#177;1&#46;97&#41;CG &#40;n&#61;11&#59; 53&#177;2&#46;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;10 min&#44; supine resting&#44; respiratory signal monitored&#41; at 3&#8211;6 wks post-event&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 12 wks&#59; 30&#8211;40 min of continuous upright aerobic and dynamic exercise&#59; &#8776;70&#8211;85&#37; max HRCG&#58; usual daily activities without restriction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; RR interval variance &#40;vs&#46; CG&#41;&#8593; RR interval &#40;not different from CG&#41;&#8592;&#8594; LF &#40;nu&#41;&#44; HF &#40;nu&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No report of infarct locationDaily physical activity and diet not assessedCG&#58; younger&#44; heavier&#44; higher levels of total cholesterol&#44; HDL and LDL than EGEG and CG&#58; Encouraged to exercise 1&#8211;3 times per week outside of the rehabilitation program&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tygesen et al&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">72</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomized&#59; no control group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-MI&#59; CABG Normal-intensity group &#40;n&#61;33&#59; 56&#46;5&#177;7&#46;7&#41;High-intensity group &#40;n&#61;29&#59; 57&#46;5&#177;8&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;10 min&#44; supine resting&#44; 15 respirations&#47;min&#41; and 24-h Holter recording at 1 month post-event&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 wks&#59; cycle ergometerNormal intensity training &#40;2&#215;&#47;wk&#44; 1 h&#41;High intensity &#40;3&#215;&#47;wk&#44; 1 h &#43; 3&#215;&#47;wk&#44; 30 min&#44; at home&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593; SDNN&#44; SDANN &#40;greater in the high intensity group&#41;&#8592;&#8594; RMSSD&#44; HF&#44; LF &#40;both groups&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedOne year later exercise capacity remained at the same level in the high intensity group and there was only an insignificant trend toward increased maximal workload in the normal intensity group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Duru et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-MIEG &#40;n&#61;12&#59; 56&#177;5&#41;CG &#40;n&#61;13&#59; 55&#177;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;15 min&#44; supine resting&#41; at &#8776;1 month post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 8 wks&#59; 2&#215; outdoor walking sessions &#40;1 h&#41; daily&#59; 4 x 45-min&#47;wk &#40;cycling&#41;&#59; 70&#37; HR reserveCG&#58; usual medical care and daily living activities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">After rehabilitation&#58;EG&#58; &#8593; pNN50&#8592;&#8594; SDRR&#44; HF &#40;nu&#41;&#44; LF &#40;nu&#41;&#44; LF&#47;HFAfter 1 year&#58;CG&#58; &#8595; SDRR&#44; HF &#40;nu&#41;None of the HRV indices were significantly different between the two groups&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedHRV evaluated before and after 1 and 2 months of training and at 12 monthsCG&#58; received usual clinical follow-up&#44; and encouraged not to exercise beyond a level associated with normal activities of daily living&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Iellamo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CAD&#44; Post-MI&#44; CABGEG &#40;n&#61;45&#59; 59&#46;4&#177;7&#46;8&#41;CG &#40;n&#61;41&#59; 58&#46;5&#177;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;10 min&#44; supine resting&#41; at 2 wks after CABG and at 2 months to 9 years post-MI &#40;66&#37; in the last year before the study&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 2 wks&#59; 2&#215;&#47;day&#59; 30 min of cycle ergometer&#59; 6&#215;&#47;wk&#59; 85&#37; max HRCG&#58; walking and calisthenics with the same daily schedule as EG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; RR interval&#44; SDRR &#40;vs&#46; CG&#41;EG&#58; &#8593; RR interval&#44; SDRR &#40;both MI and non-MI patients&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedAll patients resided at the rehabilitation center for 3 weeksEG&#58; significant increase in peak VO<span class="elsevierStyleInf">2</span>CG&#58; small significant increase in peak VO<span class="elsevierStyleInf">2</span>Half of the patients in each group were post-MI &#40;stratified analysis showed no significant difference in baseline HRV between post-MI and non-MI patients&#41;Considerable variability in time between MI and baseline evaluation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pardo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">73</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CAD&#44; Post-MI&#44; CABG&#44; angina&#44; angioplasty &#40;n&#61;20&#59; 71&#177;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24-h Holter ECG recording at &#8776;40 days post-event&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 wks&#59; 3&#215;&#47;wk&#59; 50&#8211;75&#37; HR reserve&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Entire sample&#58;&#8593; HF &#40;ln&#41;&#8592;&#8594; Mean NN&#44; SDNN&#44; SDANN index&#44; SDNN index&#44; RMSSD&#44; pNN50&#44; total power&#44; LF &#40;ln&#41;After stratification by tertiles of MET and adjustment for baseline differences in resting systolic blood pressure and exercise duration&#58;&#8593; HF &#40;ln&#41;&#44; SDNN in the highest MET increase tercile&#8592;&#8594; Mean NN&#44; SDANN index&#44; SDNN index&#44; RMSSD&#44; pNN50&#44; total power&#44; LF &#40;ln&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No report of infarct locationDaily physical activity assessed by questionnaireDiet not assessedDifferent exercise intensities used&#58; 50&#8211;75&#37; HR reserve&#44; below the ischemic threshold &#40;observed during exercise stress testing&#41;&#44; and 20&#8211;30 bpm above resting HR &#40;patients who had not undergone stress testing at program entry&#41;68&#37; of patients increased their kilocalorie expenditure by exercise training and daily physical activity over the 12-week periodExercise training significantly improved HRV in cardiac patients&#44; particularly among those who achieved a threshold of &#62;1&#46;5 training METs increase over a 12-week period&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Takeyama et al&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-MI&#44; anginaEG &#40;n&#61;13&#59; 58&#46;8&#177;6&#46;3&#41;CG &#40;n&#61;15&#59; 61&#46;7&#177;8&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;3 min&#44; supine resting&#41; and during aerobic exercise at 1 wk&#44; 3 wks&#59; 3&#44; 6 and 12 months after CABG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 2 wks&#59; 2&#215; daily&#59; 30 min of cycle ergometer at anaerobic thresholdCG&#58; 1st wk&#59; 3&#215; daily&#59; 200 m-walking and 2nd wk&#44; 500 m-walking&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593; HF at rest in both groups &#40;3&#44; 6 and 12 months&#41;EG&#58; &#8593; HF during exercise at 20 W vs&#46; CG &#40;3rd wk&#59; 3rd&#44; 6th and 12th months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No report of infarct locationDaily physical activity and diet not assessedPatients using beta-blockers excluded&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Stahle et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CAD&#44; PTCA&#44; post-MI&#44; CABG&#44; anginaEG &#40;n&#61;29&#59; 71&#177;4&#41;CG &#40;n&#61;36&#59; 72&#177;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24-h Holter ECG recording at 6 wks post-event&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 3 months&#59; 3&#215;&#47;wk&#59; 50 min&#59; 3 &#215; 4 min at &#62;85&#37; max HREG and CG&#58; recommended to take a daily walk at a comfortable speed&#44; and to increase the time&#44; length and speed of the walk gradually&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; SDNN&#44; SDANN &#40;daytime&#59; vs&#46; CG&#41;&#8592;&#8594; RMSSD&#44; ULF&#44; VLF&#44; LF&#44; HF &#40;both groups&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No report of infarct locationDaily physical activity and diet not assessed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Oya et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-MIEG &#40;n&#61;16&#59; 59&#177;7&#41;CG &#40;n&#61;12&#59; 58&#177;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;3 min&#44; supine resting&#41; and during warm-up and aerobic exercise at 1 wk&#44; 3 wks and 3 months post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 2 wks&#59; 2&#215; daily&#59; 30 min of cycle ergometer at anaerobic thresholdCG&#58; walking according to conventional rehabilitation protocol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; HF during exercise at 20 W vs&#46; CG &#40;3rd wk&#41;Delta value of HF at 20 W from 1 to 3 weeks post-AMI was significantly higher in EG &#40;30&#177;6 ms<span class="elsevierStyleSup">2</span>&#41; vs&#46; CG &#40;10&#177;8 ms<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fujimoto et al&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">First uncomplicated MIEG &#40;n&#61;20&#41;CG &#40;n&#61;20&#41;Total59&#177;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24-h Holter ECG recording at 2 wks post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2wks&#59; 2&#215; daily&#59; 10 min of cycle ergometer at 80&#37; of the anaerobic threshold &#43; conventional cardiac rehabilitation program &#40;daily living activities&#41;Control group&#58; conventional cardiac rehabilitation program &#40;daily living activities&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; SDNN&#44; SDANN&#44; HF &#40;vs&#46; control group&#41;&#8595; LF&#47;HF &#40;vs&#46; control group&#41;&#8592;&#8594; mean NN&#44; SDNN index&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Malfatto et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">First uncomplicated MICR group &#40;n&#61;19&#59; 52&#177;2&#41;BB &#43; CR group &#40;n&#61;20&#59; 53&#177;2&#41;BB group &#40;n&#61;14&#59; 53&#177;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;15&#8211;20 min&#44; supine resting&#41; at 4 wks post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 wks&#59; 5&#215;&#47;wk&#59; 1 h&#59; cycle ergometer &#40;80&#37; max HR&#41; and calisthenicsAfter 8 wk&#58; regular physical exercise at home&#44; at least 2&#8211;3&#215;&#47;wk&#59;Compliance with the exercise schedule was assessed with a questionnaire during three-month follow-up phone calls&#44; and at the end&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">After 3 months of MICR group&#58; &#8592;&#8594; SDRR&#8593; MSSD&#44; pNN50&#44; HF &#40;nu&#41;&#8595; LF &#40;nu&#41;&#44; LF&#47;HFBB &#43; CR group&#58; &#8593; SDRR&#44; MSSD&#44; pNN50&#44; HF &#40;nu&#41;&#8595; LF &#40;nu&#41;&#44; LF&#47;HFBB group&#58; &#8592;&#8594; SDRR&#44; MSSD&#44; pNN50&#44; HF &#40;nu&#41;&#44; LF &#40;nu&#41;&#44; LF&#47;HF &#40;BB group&#41;One year after MI&#58;effects maintained&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedCR group&#58; MSSD increased by 25&#37; and pNN50 by 69&#37;&#44; LF&#47;HF decreased by 40&#37;BB &#43; CR group&#58; MSSD increased by 41&#37;&#44; pNN50 by 48&#37;&#44; and LF&#47;HF decreased by 39&#37;These results indicate that the effects of CR and BB on HRV are additive and not redundantOne year after MI only some patients were revaluated &#40;CR group&#58; n&#61;16&#59; BB &#43; CR group&#58; n&#61;15&#44; and BB group&#58; n&#61;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Leitch et al&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Uncomplicated MIEG &#40;n&#61;26&#59; 56&#177;1&#41;CG &#40;n&#61;23&#59; 59&#177;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24-h Holter ECG recording at 5&#8211;7 days post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 6 wks&#59; supervised hospital-based exercise training program &#40;leg ergometry and circuit training&#41;&#59; &#8776;70&#37; max HR&#59; 3&#8211;4&#215;&#47;wk&#59; 30 min &#40;1st wk&#41; to 60 min &#40;3rd to last wk&#41;&#59;&#43;Unsupervised low-intensity home walking program &#40;gradual increase in daily walking from 5 min&#44; 2&#215;&#47;day &#91;1st wk&#93; to 30 min&#44; 2&#215;&#47;day &#91;6th wk&#93;&#41;CG&#58; only unsupervised low-intensity home walking program&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; SDNN&#44; SDANN&#44; total power&#44; LF &#40;ln&#41;&#44; HF &#40;ln&#41; &#40;no significant differences between groups&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Significant differences between groups at baseline &#40;CG&#58; total power and LF were significantly reduced compared to EG&#41;Daily physical activity and diet not assessedControl group not sedentary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bryniarski et al&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">74</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">First uncomplicated MIHypertensive group &#40;n&#61;34&#59; 52&#177;9&#46;4&#41;Normotensive group &#40;n&#61;30&#59; 53&#177;9&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24-h Holter ECG recording at 14 days post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 wks&#59; 5&#215;&#47;wk&#59; gymnastics &#40;2&#215;&#47;day&#44; 20 min&#41;&#44; cycling &#40;3&#215;&#47;wk&#44; 30&#8211;45 min&#44; 60&#8211;80&#37; max HR&#41;&#44; jogging &#40;2&#215;&#47;wk&#44; 1&#46;5 km and 100 m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593; SDNN&#44; SDANN&#44; SDNNi&#44; RMSSD&#44; pNN50 &#40;both groups&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedIncrease in exercise duration and working capacity &#40;both groups&#41;All medications known to influence autonomic function had been withdrawn &#62;72 h before the study&#44; except for short-acting nitrates for relief of anginal pain if necessary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Malfatto et al&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not randomized&#59; control group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">First uncomplicated MIEG &#40;n&#61;22&#59; 52&#177;7&#41;CG &#40;n&#61;8&#59; 53&#177;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;15&#8211;20 min&#44; supine resting&#41; at 4 wks post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 8 wks&#59; 5&#215;&#47;wk&#59; 1 h&#59; cycle ergometer &#40;80&#37; max HR&#41; and calisthenicsAfter 8 wks&#58; regular physical exercise at home&#44; at least 2&#8211;3&#215;&#47;wk&#59;Compliance with the exercise schedule was assessed with a questionnaire during three-month follow-up phone calls&#44; and at the end&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 months after MIEG&#58; &#8593; SDRR&#44; MSSD&#44; pNN50&#44; HF &#40;nu&#41; &#40;vs&#46; CG&#41;&#8595; LF &#40;nu&#41;&#44; LF&#47;HF &#40;vs&#46; CG&#41;&#8593; Mean RROne year after MI&#58;effects maintained&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedOne year after MI&#44; follow-up was completed by 18 patients &#40;12 in EG and 6 in CG&#41;&#59;One year after MI only some patients were revaluated &#40;EG&#58; n&#61;12&#59; CG&#58; n&#61;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mazzuero et al&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-MIEG &#40;n&#61;22&#41;CG &#40;n&#61;16&#41;Total50&#177;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24-h Holter ECG recording at 4&#8211;6 wks post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 6 months&#59; 3&#215;&#47;wk&#59; 30 min&#59; cycle ergometer&#59; 80&#37; peak HR&#59;CG&#58; free lifestyle of their choice&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; &#8593; Mean RR&#44; SDRR&#8592;&#8594; pNN50&#8593; LF&#47;HFNone of the HRV indices were significant different between the EG and CG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedCG&#58; told to avoid any strenuous physical activityDrug wash-outSome patients had a very low ejection fraction &#40;heart failure&#63;&#41;Ranges of HF and LF frequencies different from other studies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">La Rovere et al&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">First uncomplicated MITotal &#40;n&#61;22&#41;EG 47&#177;6CG 54&#177;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short-term ECG recording &#40;15 min&#44; supine resting&#59; 15 min tilt test&#41; and 24-h Holter ECG recording at 4 wks post-MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; 4 wks&#44; calisthenics and cycle ergometer&#59; 75&#8211;95&#37; anaerobic threshold&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8592;&#8594; HF &#40;nu&#41;&#44; LF &#40;nu&#41;&#44; LF&#47;HFEG &#40;tilt test&#41;&#58; &#8593; LF&#59; &#8595; HF&#59;&#8593; LF&#47;HF &#40;vs&#46; CG&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Daily physical activity and diet not assessedDrug wash-outEG&#58; improved response to the tilt test&#44; suggesting improvement in the reflex activity of the autonomic nervous system&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Studies of the effects of exercise training on heart rate variability in coronary artery disease patients&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:74 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Global Atlas on Cardiovascular Disease Prevention and Control"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "World Health Organization"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2011"
                        "editorial" => "World Health Organization"
                        "editorialLocalizacion" => "Geneva"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Time course of recovery of heart period variability after myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;T&#46; Bigger Jr&#46;"
                            1 => "J&#46;L&#46; Fleiss"
                            2 => "L&#46;M&#46; Rolnitzky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                      "Revista" => array:6 [
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                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Heart rate variability as an index of sympathovagal interaction after acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "F&#46; Lombardi"
                            1 => "G&#46; Sandrone"
                            2 => "S&#46; Pernpruner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "volumen" => "60"
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                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3687775"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
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Revista Portuguesa de Cardiologia (English edition)
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