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and ease of use of and level of satisfaction with the CareLink service from the standpoint of physicians and health workers&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Study variables and data collection</span><p id="par0080" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0020">Figure 4</a> presents the underlying conceptual model of the PORTLink trial and the variables to be analyzed&#46; Data will be collected through forms and questionnaires in face-to-face consultations and following each remote transmission&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">At the time of enrollment and baseline assessment&#44; the physician will explain the study&#39;s characteristics to the patient and request informed consent&#44; and will fill out a form recording data on symptoms&#44; underlying disease&#44; comorbidities&#44; previous treatment&#44; history of arrhythmias and type of CIED&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The following will be applied to the patient&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0095" class="elsevierStylePara elsevierViewall">a questionnaire on education level&#44; social support and resources used in travel to and from hospital&#59;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8226;</span><p id="par0100" class="elsevierStylePara elsevierViewall">the Hospital Anxiety and Depression Scale &#40;HADS&#41;&#44; validated in Portuguese by Pais-Ribeiro et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&#59;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0105" class="elsevierStylePara elsevierViewall">the 12-Item Short-Form Health Survey &#40;SF-12&#41;&#44; which measures perception of health-related quality of life&#44; with a physical component summary and a mental component summary&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p></li></ul></p><p id="par0110" class="elsevierStylePara elsevierViewall">In this initial phase of the study&#44; patients in groups A and C will be receive instructions about the operation of the CareLink system and transmissions will be scheduled for the 12 months of follow-up&#44; and face-to-face consultations will be scheduled for those in groups B and D&#44; with traditional follow-up&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">For patients allocated to remote monitoring&#44; patient and physician will complete questionnaires after each scheduled transmission&#46; The patient&#39;s questionnaire will record information on his or her level of satisfaction with the system&#44; while the physician&#39;s will cover technical matters including the occurrence and characterization of arrhythmias and other relevant clinical events&#44; the quality of the data transmitted&#44; time taken to analyze the data&#44; the need for intervention after assessment of the data&#44; and level of satisfaction with the system&#46; For unscheduled transmissions&#44; the reason for the transmission will be recorded&#44; as well as any resulting changes in therapy or device programming&#44; or need for hospital visits&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Patient and physician questionnaires will also be used during face-to-face follow-up consultations to enable comparison between the traditional and remote monitoring protocols&#46; These questionnaires will collect data as follows&#58;<ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">&#8226;</span><p id="par0125" class="elsevierStylePara elsevierViewall">for patients&#44; information on the type of consultation &#40;scheduled or unscheduled&#41;&#44; time spent traveling to and from the hospital&#44; type of transport used and distance traveled&#44; need to be accompanied&#44; waiting and consultation time&#44; extent of disruption to the patient&#39;s and any companion&#39;s daily routine &#40;particularly time off work&#41;&#44; and degree of satisfaction with the consultation&#46;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">&#8226;</span><p id="par0130" class="elsevierStylePara elsevierViewall">for physicians&#44; information on analysis of CIED data&#44; occurrence and characterization of arrhythmic episodes&#44; members of the team involved in the consultation&#44; type of intervention performed after assessment of the device parameters&#44; and time spent on consultations &#40;for both face-to-face and remote monitoring&#41;&#46;</p></li></ul></p><p id="par0135" class="elsevierStylePara elsevierViewall">At the final assessment&#44; after 12 months of follow-up&#44; both physician and patient will fill out forms assessing their level of satisfaction and recording clinical status&#44; arrhythmic episodes and CIED parameters&#46; A face-to-face questionnaire and the HADS and SF-12 scales will again be applied to all patients&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">During the study&#44; when applicable&#44; forms will be filled out to record any adverse clinical events &#40;whether causally related to the CIED or not&#41;&#44; study withdrawal&#44; problem resolution&#44; and any deviation from the trial design&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The questionnaires will provide data on resource use for follow-up by both the NHS and the patient&#44; enabling comparison of the mean number of face-to-face consultations&#44; both scheduled and unscheduled&#59; the total number of consultations &#40;for both groups&#41;&#59; and the mean time spent by physicians in both types of follow-up&#46; For patients&#44; the time spent in face-to-face consultations&#44; distance traveled&#44; and time off work &#40;for the patient and companion&#44; if any&#41; will be quantified&#46; This information will be used to calculate costs according to official NHS and Government methods to enable an economic comparison between traditional face-to-face follow-up and remote monitoring&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">30&#44;31</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Statistical power</span><p id="par0150" class="elsevierStylePara elsevierViewall">The statistical methods and determination of the study&#39;s statistical power&#44; and hence the sample size&#44; are defined on the basis of the trial&#39;s objectives and the characteristics of the four groups&#46; The level of significance is set at 95&#37; for each analysis&#44; with a beta error of 0&#46;20&#46; Descriptive data and comparisons between groups will be presented based on clinical variables&#44; device parameters and data collected in face-to-face consultations and remotely&#44; and information from the various questionnaires applied during the study&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Assuming that individuals undergoing CareLink remote monitoring &#40;groups A and C&#44; n&#61;100&#41; and those with traditional follow-up &#40;groups B and D&#44; n&#61;100&#41; are two independent groups&#44; it will be possible to identify differences between dichotomous variables with a prevalence of 50&#37; in the traditional follow-up groups that are associated with remote monitoring with a relative risk of &#8805;1&#46;39 or &#8804;0&#46;61&#46; It will also be possible to compare individuals with and without previous experience of face-to-face follow-up in terms of levels of satisfaction with their monitoring protocol&#46; In groups A and C &#40;remote monitoring&#41; physicians&#8217; levels of satisfaction will also be assessed&#44; and a prospective comparison will be made on ease of use and satisfaction&#44; information from scheduled and unscheduled transmissions and consultations&#44; transmission times&#44; and use of other resources&#46; Assuming each group consists of a minimum of 50 individuals and that for comparisons between remote and traditional follow-up the groups are independent&#44; it will be possible to identify differences between dichotomous variables with a prevalence of 50&#37; in the traditional follow-up groups that are associated with remote monitoring with a relative risk of &#8805;1&#46;53 or &#8804;0&#46;47&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Comparison between baseline and final data for each group&#44; assuming a minimum of 50 individuals in each group&#44; is paired&#44; and it will be possible to identify differences between dichotomous variables with a prevalence of 50&#37; on baseline assessment and a correlation coefficient of 0&#46;5 that are associated with remote monitoring with a relative risk of &#8805;1&#46;38 or &#8804;0&#46;62&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Ethical aspects</span><p id="par0165" class="elsevierStylePara elsevierViewall">The study protocol is in accordance with the ethical principles of the Declaration of Helsinki and has been approved by the Portuguese National Data Protection Commission&#44; INFARMED and the ethics committees of the participating centers&#46; All participants will provide written informed consent for inclusion in the study&#46; The trial is sponsored by Medtronic Portugal and will be monitored by supervisors from the Institute of Preventive Medicine of Lisbon University Medical School&#46; Confidentiality of personal data will be protected by making it unidentifiable&#44; participants being assigned a randomly generated unique number&#46; The data will be stored in a secure password-protected online database&#44; accessible only to study investigators and supervisors from the Institute of Preventive Medicine&#46; The monitoring committee&#44; made up of the principal clinical investigator from each center and representatives from the Institute of Preventive Medicine&#44; will act as a consulting body and will monitor how the study is performed&#59; it will also have access to the data analysis&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Discussion</span><p id="par0170" class="elsevierStylePara elsevierViewall">As more individuals receive CIEDs&#44; the population requiring follow-up for these devices is set to increase significantly&#44; particularly in high-volume centers&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;14&#8211;17</span></a> This follow-up requires regular&#44; long-term&#44; and specialized monitoring&#44; involving periodic hospital visits&#44; in order to ensure that the device is working properly and to intervene in accordance with the patient&#39;s clinical course&#44; with particular regard to the occurrence of arrhythmias and&#47;or heart failure&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> However&#44; a retrospective analysis has shown that most face-to-face consultations are in fact routine&#44; with no clinically relevant findings in 78&#46;2&#37; of cases and no changes to treatment or device programming in 90&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">The implementation of a monitoring system that can maintain safety levels while reducing the costs involved in terms of human and logistical resources is an increasingly attractive option in clinical practice&#44; with advantages in terms of satisfaction&#44; costs&#44; resource optimization and safety that have been demonstrated in several multicenter studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#8211;21</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">The ability of remote monitoring systems to provide regular assessments of the technical status of the different components of the device&#44; to detect and characterize arrhythmias and therapies applied&#44; and to identify variables associated with the risk of hospitalization for decompensated heart failure&#44; has the potential to improve the way that patients with CIEDs are monitored&#44; as shown in studies demonstrating greater efficiency with remote monitoring systems<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;22&#44;23</span></a> and reductions in overall costs per patient and in the number of hours worked by medical staff&#46; Remote monitoring<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#8211;26</span></a> also appears to be a safe option&#44; particularly regarding the early detection of device malfunction or changes in the patient&#39;s clinical status&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;19&#44;20&#44;25&#44;29</span></a> They have also been shown to be feasible and easy to use by both physicians<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;27</span></a> and patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;19&#44;28</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">However&#44; certain questions remain to be clarified with regard to remote monitoring&#44; particularly concerning safety in cases when the physician wishes to intervene after analyzing the device data but the patient is not contactable&#44; the impact on patients&#8217; quality of life&#44; and assessment of long-term satisfaction&#46; The PORTLink trial sets out to evaluate these aspects by assessing the safety&#44; efficacy&#44; costs&#44; satisfaction&#44; levels of anxiety&#44; depression and quality of life in different groups of patients with CIEDs&#44; comparing remote monitoring systems with the traditional follow-up that is currently the norm in Portugal&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflicts of interest</span><p id="par0190" class="elsevierStylePara elsevierViewall">M&#225;rio Oliveira is a member of the European Advisory Board of Medtronic&#46; The other authors have no conflicts of interest to declare&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a></p></span></span>"
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          "titulo" => "Keywords"
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          "titulo" => "Introduction"
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          "titulo" => "Methods and study design"
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          "identificador" => "sec0015"
          "titulo" => "Patient selection and randomization"
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          "identificador" => "sec0020"
          "titulo" => "Follow-up"
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        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "The Medtronic CareLink system"
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        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Specific objectives and criteria"
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        10 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Study variables and data collection"
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        11 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Statistical power"
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        12 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Ethical aspects"
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        13 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Discussion"
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        14 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Conflicts of interest"
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    "fechaRecibido" => "2012-09-06"
    "fechaAceptado" => "2013-06-25"
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        0 => array:4 [
          "clase" => "keyword"
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          "identificador" => "xpalclavsec290204"
          "palabras" => array:5 [
            0 => "Remote monitoring"
            1 => "Implantable cardioverter-defibrillator"
            2 => "Cardiac resynchronization therapy"
            3 => "Follow-up"
            4 => "CareLink"
          ]
        ]
      ]
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec290203"
          "palabras" => array:5 [
            0 => "Monitoriza&#231;&#227;o &#224; dist&#226;ncia"
            1 => "Cardioversor-desfibrilhador implant&#225;vel"
            2 => "Terap&#234;utica de ressincroniza&#231;&#227;o card&#237;aca"
            3 => "<span class="elsevierStyleItalic">Follow-up</span>"
            4 => "<span class="elsevierStyleItalic">CareLink</span>"
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">With expanding indications for cardiac implantable electronic devices &#40;CIEDs&#41; capable of treating bradycardias&#44; complex cardiac tachyarrhythmias and heart failure&#44; the number of patients requiring regular long-term specialized care is growing rapidly&#46; Currently&#44; routine face-to-face follow-up consultations for patients with CIEDs are a significant burden on hospital services&#46; Remote telemonitoring appears to offer a safe and effective alternative to conventional follow-up in this area&#46; The Medtronic CareLink Network enables remote monitoring of CIED patients&#44; and thus has the potential to improve the efficiency of medical care in this population&#46; The objective of the PORTLink &#40;PORTuguese Research on Telemonitoring with CareLink&#41; multicenter randomized trial is to assess the safety&#44; efficacy and costs of remote CIED monitoring compared to traditional face-to-face follow-up&#46; It will evaluate aspects such as physicians&#8217; and patients&#8217; acceptance of and satisfaction with reviewing device data via the website&#44; the complexity for troubleshooting calls to the support center&#44; the use of emergency resources by symptomatic patients&#44; the incidence of unscheduled consultations after remote interrogations&#44; levels of anxiety&#44; depression and quality of life&#44; and the main resources used by the CareLink system&#46; Approximately 200 patients will be randomized in up to five centers&#44; with clinical follow-up of 12 months&#46; Enrollment began in 2012 and is expected to be completed in early 2014&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Com a expans&#227;o das indica&#231;&#245;es para terap&#234;utica com dispositivos card&#237;acos implant&#225;veis &#40;DCI&#41;&#44; capazes de tratar bradiarritmias&#44; taquidisritmias ventriculares e insufici&#234;ncia card&#237;aca&#44; o n&#250;mero de doentes que necessitam de seguimento especializado regular a longo prazo tem vindo a aumentar rapidamente&#46; Atualmente&#44; as consultas de rotina com portadores de DCI envolvendo equipas multidisciplinares representam uma sobrecarga significativa na atividade hospitalar&#46; Neste contexto&#44; a monitoriza&#231;&#227;o &#224; dist&#226;ncia tem sido sugerida como uma op&#231;&#227;o segura e eficaz&#44; com grande potencial como alternativa ao seguimento convencional&#46; O sistema <span class="elsevierStyleItalic">Medtronic CareLink</span> tem sido largamente implementado na monitoriza&#231;&#227;o &#224; dist&#226;ncia&#44; podendo associar-se a melhoria na efici&#234;ncia dos programas de seguimento desta popula&#231;&#227;o&#46; O objetivo do <span class="elsevierStyleItalic">PORTuguese Research on Telemonitoring with CareLink &#40;PORTLink&#41;</span>&#44; um estudo multic&#234;ntrico randomizado&#44; &#233; avaliar a seguran&#231;a&#44; a efic&#225;cia e os custos da monitoriza&#231;&#227;o &#224; dist&#226;ncia de DCI&#44; quando comparados com o seguimento hospitalar convencional&#46; O estudo pretende avaliar aspetos como a aceita&#231;&#227;o e satisfa&#231;&#227;o da equipa m&#233;dica e doente com os dados do funcionamento do dispositivo obtidos via <span class="elsevierStyleItalic">website</span>&#44; a complexidade referida pelos v&#225;rios centros na dete&#231;&#227;o e resolu&#231;&#227;o de problemas&#44; a utiliza&#231;&#227;o dos recursos de urg&#234;ncia por doentes sintom&#225;ticos&#44; a incid&#234;ncia de consultas n&#227;o programadas&#44; os n&#237;veis de ansiedade&#44; depress&#227;o e qualidade de vida&#44; e o consumo de recursos associados ao funcionamento do sistema CareLink&#46; Ser&#227;o aleatorizados cerca de 200 doentes em at&#233; cinco centros&#44; com seguimento cl&#237;nico de 12 meses&#46; A inclus&#227;o de doentes iniciou-se em 2012 e tem conclus&#227;o prevista para o in&#237;cio de 2014&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Oliveira M&#44; Fernandes M&#44; Primo J&#44; et al&#46; Monitoriza&#231;&#227;o &#224; dist&#226;ncia versus seguimento convencional presencial em portadores de dispositivos card&#237;acos implantados&#58; racional e desenho do estudo PORTLink &#40;<span class="elsevierStyleItalic">PORTuguese Research on Telemonitoring with CareLink</span>&#41;&#46; Rev Port Cardiol&#46; 2013&#59;32&#58;957&#8211;964&#46;</p>"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">PORTLink trial groups &#40;n&#61;200&#59; 50 patients per group&#41;&#46; Blue&#58; groups with traditional face-to-face follow-up&#59; yellow&#58; groups with remote monitoring using the Medtronic CareLink&#174; system&#46;</p>"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Medtronic CareLink&#174; Monitor&#44; non-wireless &#40;left&#41; and wireless models&#46;</p>"
        ]
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        "etiqueta" => "Figure 3"
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        "mostrarFloat" => true
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Example of data transmitted by the Medtronic CareLink&#174; system&#46;</p>"
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      ]
      3 => array:7 [
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        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
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          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Conceptual model of the PORTLink trial&#46;</p>"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Medtronic devices compatible with the CareLink 2490G monitor&#58; Marquis&#44; Maximo&#44; Entrust and Intrinsic &#40;ICDs&#41;&#44; and InSync Marquis&#44; InSyncII Marquis&#44; Marquis&#44; InSync Maximo and Insync Sentry &#40;CRT-Ds&#41;&#46; Devices compatible with the CareLink 2490C monitor&#58; iVirtuoso&#44; Maximo II&#44; Virtuoso II&#44; Secura&#44; Concerto&#44; Concerto II and Consulta&#46; Abbreviations as in text&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Inclusion criteria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Patients with CIEDs followed in face-to-face consultations- Patients with Medtronic ICD or CRT-D- Able to use the CareLink service according to assessment by a specialist and willing to use it- Provision of written informed consent&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Exclusion criteria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Any clinical condition that limits participation in the trial- Those with an ICD compatible only with the non-wireless CareLink 2490G monitor and without telephone access- Age under 18- Participating in another clinical trial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Study withdrawal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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Original Article
Remote monitoring versus conventional follow-up for implantable cardiac devices: Rationale and design of the PORTLink (PORTuguese Research on Telemonitoring with CareLink) trial
Monitorização à distância versus seguimento convencional presencial em portadores de dispositivos cardíacos implantados: racional e desenho do estudo PORTLink (PORTuguese Research on Telemonitoring with CareLink)
Mário Oliveiraa,
Corresponding author
m.martinsoliveira@gmail.com

Corresponding author.
, Milene Fernandesb, João Primoc, Hipólito Reisd, Paulo Nicolab, on behalf of the PORTLink study Executive Board, Investigators
a Centro Hospitalar Lisboa Central, Lisboa, Portugal
b Instituto de Medicina Preventiva, Faculdade de Medicina de Lisboa, Lisboa, Portugal
c Centro Hospitalar Vila Nova de Gaia, Vila Nova de Gaia, Portugal
d Centro Hospitalar do Porto, Porto, Portugal
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">PORTLink trial groups &#40;n&#61;200&#59; 50 patients per group&#41;&#46; Blue&#58; groups with traditional face-to-face follow-up&#59; yellow&#58; groups with remote monitoring using the Medtronic CareLink&#174; system&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The last decade has seen a significant increase in the use of cardiac implantable electronic devices &#40;CIEDs&#41; as a consequence of the demonstrated benefits of implantable cardioverter-defibrillators &#40;ICDs&#41; and cardiac resynchronization therapy defibrillator &#40;CRT-D&#41; devices in reducing mortality in selected patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Between 1990 and 2002 the number of ICDs implanted in the US grew more than 10-fold&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> while a similar increase was seen between 2000 and 2010 in Portugal&#44; reaching 100 devices per million population in 2010&#44; approaching the European average of 150 per million in 2007&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> However&#44; it has been suggested that not all patients eligible for an ICD receive this therapy&#44; which means that if all potential candidates were to be implanted&#44; the hospital resources available for clinical follow-up of these patients would be overwhelmed and unable to cope&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> Growth in this area has already had an impact on management of the resources required to deal with the increasing numbers of patients needing specialized follow-up consultations&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> The task of monitoring the operating parameters of the different devices&#44; including identification and resolution of problems&#44; detection and treatment of arrhythmias&#44; and ensuring reliable biventricular stimulation&#44; as well as providing other specialist clinical care&#44; requires a trained and skillful hospital team&#46; Furthermore&#44; in most cases follow-up consultations for CIEDs are scheduled at 3- to 6-month intervals&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#8211;10</span></a> If the population with CIEDs continues to expand&#44; this will lead to an exponential increase in the number of follow-up visits&#44; placing enormous strain on hospitals&#8217; resources&#44; including specialist human resources&#44; which in this area of cardiology are relatively scarce&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Against this background&#44; the use of remote monitoring systems has become a topic of much debate&#46; Telemedicine systems for remote monitoring of CIEDs are already available and are changing the follow-up of these patients&#59; their benefits and safety are well documented&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#8211;12</span></a> However&#44; certain questions&#44; both clinical and technical&#44; arising from the increasing use of these systems in clinical practice&#44; need to be addressed&#46; The PORTLink &#40;PORTuguese Research on Telemonitoring with CareLink&#41; trial sets out to assess whether the CareLink remote monitoring system &#40;Medtronic Inc&#46;&#44; Minneapolis&#44; MN&#44; USA&#41; improves the efficiency of follow-up in patients with CIEDs in terms of safety&#44; efficacy&#44; patients&#8217; and physicians&#8217; satisfaction&#44; and resource use&#44; compared to traditional face-to-face follow-up&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Methods and study design</span><p id="par0015" class="elsevierStylePara elsevierViewall">PORTLink is a controlled&#44; non-blinded&#44; multicenter prospective randomized clinical trial with parallel groups in Portuguese hospitals&#46; The study population will be enrolled between 2012 and 2014&#44; 200 patients being randomized and followed for 12 months&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Patient selection and randomization</span><p id="par0020" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the trial&#39;s inclusion and exclusion criteria&#46; Eligibility will be confirmed during the enrollment period in consultations with patients with CIEDs&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">After enrollment&#44; eligible patients will be allocated randomly in a 1&#58;1&#58;1&#58;1 ratio to one of four groups&#58; group A&#44; with a newly implanted CIED and no previous experience of follow-up&#44; who will begin remote monitoring with the CareLink system&#59; group B&#44; with a newly implanted CIED and no previous experience of follow-up&#44; who will begin traditional monitoring in face-to-face consultations&#59; group C&#44; with experience of monitoring in face-to-face consultations&#44; who will begin remote monitoring with the CareLink system&#59; and group D&#44; with experience of monitoring in who will maintain this monitoring protocol&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Follow-up</span><p id="par0030" class="elsevierStylePara elsevierViewall">At the first outpatient visit after randomization and provision of informed consent&#44; patients will be advised of what type of follow-up they will receive&#44; and patients in groups A and C will be informed about how the CareLink system functions and the number of scheduled transmissions during the 12-month follow-up&#46; Those in groups B and D&#44; with traditional face-to-face follow-up&#44; will have three or four scheduled visits during the 12-month period&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In accordance with the Heart Rhythm Society&#47;European Heart Rhythm Association &#40;HRS&#47;EHRA&#41; guidelines on the monitoring of CIEDs&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> the device will be monitored within 72 hours of implantation &#40;face-to-face&#41;&#44; 2&#8211;12 weeks after implantation &#40;face-to-face&#41;&#44; and then every 3&#8211;6 months &#40;face-to-face or remote&#41;&#46; Patients with remote monitoring will undergo annual face-to-face assessment&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">The Medtronic CareLink system</span><p id="par0040" class="elsevierStylePara elsevierViewall">The Medtronic CareLink system for remote monitoring of Medtronic CIEDs combines computer and biomedical technology to create an interface for transferring data from the device to the clinic&#46; It has been used in various Portuguese hospitals since 2009 and hundreds of patients are now being followed by this method &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">The system consists of the CareLink Monitor for use by the patient&#44; which transfers data from Medtronic CIEDs &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#44; and the CareLink software used by the team responsible for follow-up&#46; The device can be interrogated manually using a wand linked to the monitor in the patient&#39;s home&#44; or automatically using wireless systems&#46; Data can be scheduled to be transmitted regularly and can be sent when clinical circumstances dictate&#44; by agreement between the patient and the team&#46; The data are transmitted to a central &#40;internet-based&#41; data repository&#44; access to which is limited&#44; each center only having access to data on its own patients through a password-protected web page&#46; Members of the hospital team can access the CareLink program in order to consult and analyze the data transmitted by the monitor&#44; including changes in device parameters&#44; arrhythmic episodes recorded on intracavitary electrograms&#44; therapies delivered by the device&#44; the percentage of different pacing modes and tachyarrhythmias treated &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Specific objectives and criteria</span><p id="par0050" class="elsevierStylePara elsevierViewall">The PORTLink study sets out to assess the level of satisfaction&#44; clinical benefit&#44; safety and resource use of remote monitoring with the Medtronic CareLink Network in patients with CIEDs compared to traditional face-to-face follow-up&#46; The following criteria will be used to compare the different follow-up protocols&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0055" class="elsevierStylePara elsevierViewall">the proportion of patients satisfied with their monitoring protocol</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0060" class="elsevierStylePara elsevierViewall">the proportion of adverse events identified</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0065" class="elsevierStylePara elsevierViewall">the proportion of unscheduled face-to-face consultations and the reasons for them</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0070" class="elsevierStylePara elsevierViewall">the proportion of resources consumed from the standpoint of the patient and of the National Health Service &#40;NHS&#41;&#46;</p></li></ul></p><p id="par0075" class="elsevierStylePara elsevierViewall">Other criteria to be assessed in the remote monitoring groups are the proportion of successful transmissions without need for additional telephone contact&#44; and ease of use of and level of satisfaction with the CareLink service from the standpoint of physicians and health workers&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Study variables and data collection</span><p id="par0080" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0020">Figure 4</a> presents the underlying conceptual model of the PORTLink trial and the variables to be analyzed&#46; Data will be collected through forms and questionnaires in face-to-face consultations and following each remote transmission&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">At the time of enrollment and baseline assessment&#44; the physician will explain the study&#39;s characteristics to the patient and request informed consent&#44; and will fill out a form recording data on symptoms&#44; underlying disease&#44; comorbidities&#44; previous treatment&#44; history of arrhythmias and type of CIED&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The following will be applied to the patient&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0095" class="elsevierStylePara elsevierViewall">a questionnaire on education level&#44; social support and resources used in travel to and from hospital&#59;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8226;</span><p id="par0100" class="elsevierStylePara elsevierViewall">the Hospital Anxiety and Depression Scale &#40;HADS&#41;&#44; validated in Portuguese by Pais-Ribeiro et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&#59;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0105" class="elsevierStylePara elsevierViewall">the 12-Item Short-Form Health Survey &#40;SF-12&#41;&#44; which measures perception of health-related quality of life&#44; with a physical component summary and a mental component summary&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p></li></ul></p><p id="par0110" class="elsevierStylePara elsevierViewall">In this initial phase of the study&#44; patients in groups A and C will be receive instructions about the operation of the CareLink system and transmissions will be scheduled for the 12 months of follow-up&#44; and face-to-face consultations will be scheduled for those in groups B and D&#44; with traditional follow-up&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">For patients allocated to remote monitoring&#44; patient and physician will complete questionnaires after each scheduled transmission&#46; The patient&#39;s questionnaire will record information on his or her level of satisfaction with the system&#44; while the physician&#39;s will cover technical matters including the occurrence and characterization of arrhythmias and other relevant clinical events&#44; the quality of the data transmitted&#44; time taken to analyze the data&#44; the need for intervention after assessment of the data&#44; and level of satisfaction with the system&#46; For unscheduled transmissions&#44; the reason for the transmission will be recorded&#44; as well as any resulting changes in therapy or device programming&#44; or need for hospital visits&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Patient and physician questionnaires will also be used during face-to-face follow-up consultations to enable comparison between the traditional and remote monitoring protocols&#46; These questionnaires will collect data as follows&#58;<ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">&#8226;</span><p id="par0125" class="elsevierStylePara elsevierViewall">for patients&#44; information on the type of consultation &#40;scheduled or unscheduled&#41;&#44; time spent traveling to and from the hospital&#44; type of transport used and distance traveled&#44; need to be accompanied&#44; waiting and consultation time&#44; extent of disruption to the patient&#39;s and any companion&#39;s daily routine &#40;particularly time off work&#41;&#44; and degree of satisfaction with the consultation&#46;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">&#8226;</span><p id="par0130" class="elsevierStylePara elsevierViewall">for physicians&#44; information on analysis of CIED data&#44; occurrence and characterization of arrhythmic episodes&#44; members of the team involved in the consultation&#44; type of intervention performed after assessment of the device parameters&#44; and time spent on consultations &#40;for both face-to-face and remote monitoring&#41;&#46;</p></li></ul></p><p id="par0135" class="elsevierStylePara elsevierViewall">At the final assessment&#44; after 12 months of follow-up&#44; both physician and patient will fill out forms assessing their level of satisfaction and recording clinical status&#44; arrhythmic episodes and CIED parameters&#46; A face-to-face questionnaire and the HADS and SF-12 scales will again be applied to all patients&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">During the study&#44; when applicable&#44; forms will be filled out to record any adverse clinical events &#40;whether causally related to the CIED or not&#41;&#44; study withdrawal&#44; problem resolution&#44; and any deviation from the trial design&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The questionnaires will provide data on resource use for follow-up by both the NHS and the patient&#44; enabling comparison of the mean number of face-to-face consultations&#44; both scheduled and unscheduled&#59; the total number of consultations &#40;for both groups&#41;&#59; and the mean time spent by physicians in both types of follow-up&#46; For patients&#44; the time spent in face-to-face consultations&#44; distance traveled&#44; and time off work &#40;for the patient and companion&#44; if any&#41; will be quantified&#46; This information will be used to calculate costs according to official NHS and Government methods to enable an economic comparison between traditional face-to-face follow-up and remote monitoring&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">30&#44;31</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Statistical power</span><p id="par0150" class="elsevierStylePara elsevierViewall">The statistical methods and determination of the study&#39;s statistical power&#44; and hence the sample size&#44; are defined on the basis of the trial&#39;s objectives and the characteristics of the four groups&#46; The level of significance is set at 95&#37; for each analysis&#44; with a beta error of 0&#46;20&#46; Descriptive data and comparisons between groups will be presented based on clinical variables&#44; device parameters and data collected in face-to-face consultations and remotely&#44; and information from the various questionnaires applied during the study&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Assuming that individuals undergoing CareLink remote monitoring &#40;groups A and C&#44; n&#61;100&#41; and those with traditional follow-up &#40;groups B and D&#44; n&#61;100&#41; are two independent groups&#44; it will be possible to identify differences between dichotomous variables with a prevalence of 50&#37; in the traditional follow-up groups that are associated with remote monitoring with a relative risk of &#8805;1&#46;39 or &#8804;0&#46;61&#46; It will also be possible to compare individuals with and without previous experience of face-to-face follow-up in terms of levels of satisfaction with their monitoring protocol&#46; In groups A and C &#40;remote monitoring&#41; physicians&#8217; levels of satisfaction will also be assessed&#44; and a prospective comparison will be made on ease of use and satisfaction&#44; information from scheduled and unscheduled transmissions and consultations&#44; transmission times&#44; and use of other resources&#46; Assuming each group consists of a minimum of 50 individuals and that for comparisons between remote and traditional follow-up the groups are independent&#44; it will be possible to identify differences between dichotomous variables with a prevalence of 50&#37; in the traditional follow-up groups that are associated with remote monitoring with a relative risk of &#8805;1&#46;53 or &#8804;0&#46;47&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Comparison between baseline and final data for each group&#44; assuming a minimum of 50 individuals in each group&#44; is paired&#44; and it will be possible to identify differences between dichotomous variables with a prevalence of 50&#37; on baseline assessment and a correlation coefficient of 0&#46;5 that are associated with remote monitoring with a relative risk of &#8805;1&#46;38 or &#8804;0&#46;62&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Ethical aspects</span><p id="par0165" class="elsevierStylePara elsevierViewall">The study protocol is in accordance with the ethical principles of the Declaration of Helsinki and has been approved by the Portuguese National Data Protection Commission&#44; INFARMED and the ethics committees of the participating centers&#46; All participants will provide written informed consent for inclusion in the study&#46; The trial is sponsored by Medtronic Portugal and will be monitored by supervisors from the Institute of Preventive Medicine of Lisbon University Medical School&#46; Confidentiality of personal data will be protected by making it unidentifiable&#44; participants being assigned a randomly generated unique number&#46; The data will be stored in a secure password-protected online database&#44; accessible only to study investigators and supervisors from the Institute of Preventive Medicine&#46; The monitoring committee&#44; made up of the principal clinical investigator from each center and representatives from the Institute of Preventive Medicine&#44; will act as a consulting body and will monitor how the study is performed&#59; it will also have access to the data analysis&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Discussion</span><p id="par0170" class="elsevierStylePara elsevierViewall">As more individuals receive CIEDs&#44; the population requiring follow-up for these devices is set to increase significantly&#44; particularly in high-volume centers&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;14&#8211;17</span></a> This follow-up requires regular&#44; long-term&#44; and specialized monitoring&#44; involving periodic hospital visits&#44; in order to ensure that the device is working properly and to intervene in accordance with the patient&#39;s clinical course&#44; with particular regard to the occurrence of arrhythmias and&#47;or heart failure&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> However&#44; a retrospective analysis has shown that most face-to-face consultations are in fact routine&#44; with no clinically relevant findings in 78&#46;2&#37; of cases and no changes to treatment or device programming in 90&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">The implementation of a monitoring system that can maintain safety levels while reducing the costs involved in terms of human and logistical resources is an increasingly attractive option in clinical practice&#44; with advantages in terms of satisfaction&#44; costs&#44; resource optimization and safety that have been demonstrated in several multicenter studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#8211;21</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">The ability of remote monitoring systems to provide regular assessments of the technical status of the different components of the device&#44; to detect and characterize arrhythmias and therapies applied&#44; and to identify variables associated with the risk of hospitalization for decompensated heart failure&#44; has the potential to improve the way that patients with CIEDs are monitored&#44; as shown in studies demonstrating greater efficiency with remote monitoring systems<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;22&#44;23</span></a> and reductions in overall costs per patient and in the number of hours worked by medical staff&#46; Remote monitoring<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#8211;26</span></a> also appears to be a safe option&#44; particularly regarding the early detection of device malfunction or changes in the patient&#39;s clinical status&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;19&#44;20&#44;25&#44;29</span></a> They have also been shown to be feasible and easy to use by both physicians<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;27</span></a> and patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;19&#44;28</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">However&#44; certain questions remain to be clarified with regard to remote monitoring&#44; particularly concerning safety in cases when the physician wishes to intervene after analyzing the device data but the patient is not contactable&#44; the impact on patients&#8217; quality of life&#44; and assessment of long-term satisfaction&#46; The PORTLink trial sets out to evaluate these aspects by assessing the safety&#44; efficacy&#44; costs&#44; satisfaction&#44; levels of anxiety&#44; depression and quality of life in different groups of patients with CIEDs&#44; comparing remote monitoring systems with the traditional follow-up that is currently the norm in Portugal&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflicts of interest</span><p id="par0190" class="elsevierStylePara elsevierViewall">M&#225;rio Oliveira is a member of the European Advisory Board of Medtronic&#46; The other authors have no conflicts of interest to declare&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a></p></span></span>"
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          "titulo" => "The Medtronic CareLink system"
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        9 => array:2 [
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          "titulo" => "Specific objectives and criteria"
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          "titulo" => "Study variables and data collection"
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          "titulo" => "Statistical power"
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          "titulo" => "Ethical aspects"
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        13 => array:2 [
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          "titulo" => "Discussion"
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          "titulo" => "Conflicts of interest"
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          "titulo" => "References"
        ]
      ]
    ]
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    "fechaRecibido" => "2012-09-06"
    "fechaAceptado" => "2013-06-25"
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          "clase" => "keyword"
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            0 => "Remote monitoring"
            1 => "Implantable cardioverter-defibrillator"
            2 => "Cardiac resynchronization therapy"
            3 => "Follow-up"
            4 => "CareLink"
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        ]
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          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec290203"
          "palabras" => array:5 [
            0 => "Monitoriza&#231;&#227;o &#224; dist&#226;ncia"
            1 => "Cardioversor-desfibrilhador implant&#225;vel"
            2 => "Terap&#234;utica de ressincroniza&#231;&#227;o card&#237;aca"
            3 => "<span class="elsevierStyleItalic">Follow-up</span>"
            4 => "<span class="elsevierStyleItalic">CareLink</span>"
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">With expanding indications for cardiac implantable electronic devices &#40;CIEDs&#41; capable of treating bradycardias&#44; complex cardiac tachyarrhythmias and heart failure&#44; the number of patients requiring regular long-term specialized care is growing rapidly&#46; Currently&#44; routine face-to-face follow-up consultations for patients with CIEDs are a significant burden on hospital services&#46; Remote telemonitoring appears to offer a safe and effective alternative to conventional follow-up in this area&#46; The Medtronic CareLink Network enables remote monitoring of CIED patients&#44; and thus has the potential to improve the efficiency of medical care in this population&#46; The objective of the PORTLink &#40;PORTuguese Research on Telemonitoring with CareLink&#41; multicenter randomized trial is to assess the safety&#44; efficacy and costs of remote CIED monitoring compared to traditional face-to-face follow-up&#46; It will evaluate aspects such as physicians&#8217; and patients&#8217; acceptance of and satisfaction with reviewing device data via the website&#44; the complexity for troubleshooting calls to the support center&#44; the use of emergency resources by symptomatic patients&#44; the incidence of unscheduled consultations after remote interrogations&#44; levels of anxiety&#44; depression and quality of life&#44; and the main resources used by the CareLink system&#46; Approximately 200 patients will be randomized in up to five centers&#44; with clinical follow-up of 12 months&#46; Enrollment began in 2012 and is expected to be completed in early 2014&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Com a expans&#227;o das indica&#231;&#245;es para terap&#234;utica com dispositivos card&#237;acos implant&#225;veis &#40;DCI&#41;&#44; capazes de tratar bradiarritmias&#44; taquidisritmias ventriculares e insufici&#234;ncia card&#237;aca&#44; o n&#250;mero de doentes que necessitam de seguimento especializado regular a longo prazo tem vindo a aumentar rapidamente&#46; Atualmente&#44; as consultas de rotina com portadores de DCI envolvendo equipas multidisciplinares representam uma sobrecarga significativa na atividade hospitalar&#46; Neste contexto&#44; a monitoriza&#231;&#227;o &#224; dist&#226;ncia tem sido sugerida como uma op&#231;&#227;o segura e eficaz&#44; com grande potencial como alternativa ao seguimento convencional&#46; O sistema <span class="elsevierStyleItalic">Medtronic CareLink</span> tem sido largamente implementado na monitoriza&#231;&#227;o &#224; dist&#226;ncia&#44; podendo associar-se a melhoria na efici&#234;ncia dos programas de seguimento desta popula&#231;&#227;o&#46; O objetivo do <span class="elsevierStyleItalic">PORTuguese Research on Telemonitoring with CareLink &#40;PORTLink&#41;</span>&#44; um estudo multic&#234;ntrico randomizado&#44; &#233; avaliar a seguran&#231;a&#44; a efic&#225;cia e os custos da monitoriza&#231;&#227;o &#224; dist&#226;ncia de DCI&#44; quando comparados com o seguimento hospitalar convencional&#46; O estudo pretende avaliar aspetos como a aceita&#231;&#227;o e satisfa&#231;&#227;o da equipa m&#233;dica e doente com os dados do funcionamento do dispositivo obtidos via <span class="elsevierStyleItalic">website</span>&#44; a complexidade referida pelos v&#225;rios centros na dete&#231;&#227;o e resolu&#231;&#227;o de problemas&#44; a utiliza&#231;&#227;o dos recursos de urg&#234;ncia por doentes sintom&#225;ticos&#44; a incid&#234;ncia de consultas n&#227;o programadas&#44; os n&#237;veis de ansiedade&#44; depress&#227;o e qualidade de vida&#44; e o consumo de recursos associados ao funcionamento do sistema CareLink&#46; Ser&#227;o aleatorizados cerca de 200 doentes em at&#233; cinco centros&#44; com seguimento cl&#237;nico de 12 meses&#46; A inclus&#227;o de doentes iniciou-se em 2012 e tem conclus&#227;o prevista para o in&#237;cio de 2014&#46;</p>"
      ]
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Oliveira M&#44; Fernandes M&#44; Primo J&#44; et al&#46; Monitoriza&#231;&#227;o &#224; dist&#226;ncia versus seguimento convencional presencial em portadores de dispositivos card&#237;acos implantados&#58; racional e desenho do estudo PORTLink &#40;<span class="elsevierStyleItalic">PORTuguese Research on Telemonitoring with CareLink</span>&#41;&#46; Rev Port Cardiol&#46; 2013&#59;32&#58;957&#8211;964&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">PORTLink trial groups &#40;n&#61;200&#59; 50 patients per group&#41;&#46; Blue&#58; groups with traditional face-to-face follow-up&#59; yellow&#58; groups with remote monitoring using the Medtronic CareLink&#174; system&#46;</p>"
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          "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Medtronic devices compatible with the CareLink 2490G monitor&#58; Marquis&#44; Maximo&#44; Entrust and Intrinsic &#40;ICDs&#41;&#44; and InSync Marquis&#44; InSyncII Marquis&#44; Marquis&#44; InSync Maximo and Insync Sentry &#40;CRT-Ds&#41;&#46; Devices compatible with the CareLink 2490C monitor&#58; iVirtuoso&#44; Maximo II&#44; Virtuoso II&#44; Secura&#44; Concerto&#44; Concerto II and Consulta&#46; Abbreviations as in text&#46;</p>"
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                  <table border="0" frame="\n
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                  \t\t\t\t">Inclusion criteria&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">- Patients with CIEDs followed in face-to-face consultations- Patients with Medtronic ICD or CRT-D- Able to use the CareLink service according to assessment by a specialist and willing to use it- Provision of written informed consent&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Exclusion criteria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">- Any clinical condition that limits participation in the trial- Those with an ICD compatible only with the non-wireless CareLink 2490G monitor and without telephone access- Age under 18- Participating in another clinical trial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t">Study withdrawal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">- Patients who change to a different hospital for CIED follow-up- Occurrence of severe incapacity with no possibility of support from family or healthcare provider- Death&nbsp;\t\t\t\t\t\t\n
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Article information
ISSN: 21742049
Original language: English
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Idiomas
Revista Portuguesa de Cardiologia (English edition)
en pt

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