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with no history of disease and not taking regular medication&#44; came to the emergency department for right lower back pain and worsening dyspnea on moderate exertion of one week&#39;s duration&#46; She reported no fever&#44; cough or expectoration&#44; and was normotensive&#44; with tachyarrhythmia and mild hypoxemic respiratory failure&#46; Laboratory tests showed signs of inflammation and infection&#44; the ECG revealed atrial fibrillation with rapid ventricular rate &#40;&#8776;115 bpm&#41;&#44; and the chest X-ray showed increased cardiothoracic index and segmental infiltrate in the mid third of the right hemithorax &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was admitted with a diagnosis of community-acquired pneumonia&#44; and empirical antibiotic therapy was begun with ceftriaxone and azithromycin&#46; Thoracic computed tomography &#40;CT&#41; on the second day of hospitalization showed bilateral lung condensations&#44; bilateral pleural effusion and PE&#44; which on transthoracic echocardiography &#40;TTE&#41; measured 10 mm at the posterior wall in diastole&#44; with no signs of cardiac tamponade&#46; On the same day&#44; there was a sudden deterioration of the clinical setting&#44; evolving to septic shock&#44; and the patient was transferred to the intensive care unit&#46; Inotropic support was required for three days&#44; but chemical cardioversion to sinus rhythm was achieved on the second day&#46; On the third day&#44; multisusceptible <span class="elsevierStyleItalic">Streptococcus pneumoniae</span> was identified in blood samples collected at admission and therapy was begun with penicillin G&#46; Respiratory and hemodynamic stabilization was achieved from the fourth day&#44; although the patient still required mechanical ventilation and remained febrile&#44; with no resolution of the infection on laboratory tests&#46; The cardiac silhouette was still enlarged and serial TTE showed progressive worsening of the PE&#44; which measured 20 mm at the posterior wall in diastole on the 10th day&#44; with signs of cardiac tamponade &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">Figures 2 and 3</a>A&#41;&#46; Pericardiocentesis was therefore performed for diagnostic purposes and drainage&#44; 800 cc of fibrinous purulent fluid being drained &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>B&#41;&#44; which was negative on bacteriological study&#44; both direct and in culture&#46; Screening for acid-alcohol resistant bacilli &#40;AARB&#41; was also negative&#46; Subsequent TTE revealed resolution of the effusion&#44; accompanied by clinical&#44; radiological and laboratory improvement &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Figure 4</a>&#41;&#46; Screening for immune deficiency diseases was negative&#46; The patient presented no constrictive pattern on TTE at 12-month follow-up&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Case 2</span><p id="par0025" class="elsevierStylePara elsevierViewall">A 33-year-old man had a history of congenital hypogammaglobulinemia &#40;diagnosed in 2001&#41;&#44; chronic alcoholism and recurrent pneumonia&#44; the last episode &#40;in 2005&#41; having been complicated by pleural effusion requiring decortication&#46; He had taken no medication since 2005&#46; He came to the emergency department for fever and worsening dyspnea over the previous five days&#46; At admission&#44; he was febrile&#44; prostrate&#44; tachycardic and hypotensive&#46; Laboratory tests showed marked elevation of inflammatory and infectious parameters and arterial blood gas analysis revealed hypoxemic respiratory failure&#46; A chest X-ray showed a markedly enlarged cardiac silhouette&#44; with no parenchymal lung lesions&#59; TTE was therefore performed&#44; which confirmed the presence of a PE&#44; measuring 23 mm at the posterior wall in diastole&#44; with abnormal motion and diastolic collapse of the right atrial free wall &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Figure 5</a>A and B&#41;&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">In view of the setting of septic&#47;obstructive shock&#44; the patient was transferred to the intensive care unit&#44; and diagnostic and therapeutic pericardiocentesis was performed&#44; 700 cc of purulent fluid being drained &#40;<a class="elsevierStyleCrossRef" href="#fig0030">Figure 6</a>&#41;&#46;</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Thoracic CT following pericardiocentesis showed a moderate PE&#44; a small right pleural effusion and an area of parenchymal condensation in the superior and posterior segments of the left lower lobe&#44; with air bronchograms&#44; highly suggestive of inflammation&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The patient remained in cardiocirculatory shock and required inotropic support until the seventh day of hospitalization&#46; Initially&#44; the fluid drained was purulent&#44; and then became serofibrinous&#46; On the ninth day&#44; the absence of pericardial fluid and evidence of a considerable reduction in the effusion &#40;to 3 mm&#41; at the posterior wall in diastole led to removal of the drain&#46; Empirical antibiotic therapy with ceftriaxone and vancomycin had been begun at admission&#44; which was changed to penicillin G on the third day following confirmation of multisusceptible <span class="elsevierStyleItalic">Streptococcus pneumoniae</span> bacteremia&#46; The presence of pneumococcus with the same susceptibility was confirmed in pericardial fluid&#44; and screening for AARB was negative&#46; Immunoglobulin was administered for four days&#44; which was well tolerated and without complications&#46; Fever returned on the 14th day&#44; and TTE revealed a 15-mm PE at the posterior wall in diastole&#59; repeat thoracic CT showed loci of pleural empyema&#46; The patient was transferred to the thoracic surgery department of Coimbra University Hospitals&#44; where he underwent surgical drainage and decortication of both pleurae&#44; pericardiotomy and creation of a pleuropericardial window&#44; resulting in considerable improvement in clinical and laboratory parameters &#40;<a class="elsevierStyleCrossRef" href="#fig0035">Figure 7</a>&#41;&#46;</p><elsevierMultimedia ident="fig0035"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">The patient presented no constrictive pattern on TTE at 12-month follow-up&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Discussion</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Pericardial effusion</span><p id="par0050" class="elsevierStylePara elsevierViewall">PE may develop as a result of pericarditis or arise as an epiphenomenon of greater or less clinical significance in a range of systemic disorders&#46; The etiology of moderate PE is idiopathic in 29&#37; of cases&#44; but can be iatrogenic &#40;16&#37;&#41;&#44; or due to neoplasms &#40;13&#37;&#41;&#44; myocardial infarction &#40;8&#37;&#41;&#44; uremia &#40;6&#37;&#41;&#44; connective tissue or thyroid disease &#40;5&#37;&#41; or infection &#40;2&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The etiological distribution of PE of acute presentation with cardiorespiratory symptoms is different&#58; neoplasm &#40;33&#37;&#41;&#44; idiopathic &#40;14&#37;&#41;&#44; acute pericarditis &#40;12&#37;&#41;&#44; trauma &#40;12&#37;&#41;&#44; uremia &#40;6&#37;&#41;&#44; post-pericardiotomy &#40;5&#37;&#41; and infection &#40;5&#37;&#44; 4&#37; bacterial&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">It is essential to exclude PE in the following clinical contexts&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0065" class="elsevierStylePara elsevierViewall">acute pericarditis&#59;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0070" class="elsevierStylePara elsevierViewall">enlarged cardiac silhouette without pulmonary congestion&#59;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#46;</span><p id="par0075" class="elsevierStylePara elsevierViewall">severe hemodynamic deterioration following an acute coronary event&#44; heart surgery or invasive cardiac procedure&#59; and</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#46;</span><p id="par0080" class="elsevierStylePara elsevierViewall">persistent unexplained fever&#44; whether or not the cause is determined&#46;</p></li></ul></p><p id="par0085" class="elsevierStylePara elsevierViewall">A systematic approach to PE involves three stages<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">1&#46;</span><p id="par0090" class="elsevierStylePara elsevierViewall">confirmation by TTE&#59;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">2&#46;</span><p id="par0095" class="elsevierStylePara elsevierViewall">assessment of hemodynamic repercussions &#40;covering a wide spectrum of severity from benign to life-threatening&#44; depending on its volume&#44; the rate at which the effusion accumulates and pericardial elasticity&#41;&#59; and</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">3&#46;</span><p id="par0100" class="elsevierStylePara elsevierViewall">determination of etiology&#46;</p></li></ul></p><p id="par0105" class="elsevierStylePara elsevierViewall">With regard to etiological determination&#44; certain clinical contexts justify a non-invasive approach&#44; including recent myocardial infarction&#44; hypothyroidism and renal failure&#46; In other cases&#44; diagnosis is based on clinical evaluation as well as biochemical and bacteriological study of pericardial fluid or of the pericardium itself&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Pericardiocentesis has limited diagnostic value &#40;6&#37; of cases&#41; in acute pericarditis&#46; In patients with large chronic effusions&#44; analysis of pericardial fluid leads to a definitive diagnosis in 36&#37; and a probable diagnosis in 40&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Pericardiocentesis guided by echography or fluoroscopy is formally indicated<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> in cases of&#58;<ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">1&#46;</span><p id="par0120" class="elsevierStylePara elsevierViewall">cardiac tamponade&#59;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">2&#46;</span><p id="par0125" class="elsevierStylePara elsevierViewall">effusion of &#62;20 mm that does not respond after a week of conservative treatment with non-steroidal anti-inflammatory drugs&#59; and</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">3&#46;</span><p id="par0130" class="elsevierStylePara elsevierViewall">clinical suspicion of purulent&#44; tuberculous or neoplastic pericarditis&#46;</p></li></ul></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Purulent pericarditis</span><p id="par0135" class="elsevierStylePara elsevierViewall">Purulent pericarditis is defined as an infection in the pericardial space that produces macroscopically or microscopically purulent fluid&#46; It may be primary &#40;extremely rare&#41; or secondary to another infectious process&#46; There are five pathogenic mechanisms that can lead to invasion of the pericardial space in secondary purulent pericarditis<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#58;<ul class="elsevierStyleList" id="lis0030"><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">1&#46;</span><p id="par0140" class="elsevierStylePara elsevierViewall">contiguous spread from an intrathoracic site&#59;</p></li><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">2&#46;</span><p id="par0145" class="elsevierStylePara elsevierViewall">hematogenous spread&#59;</p></li><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">3&#46;</span><p id="par0150" class="elsevierStylePara elsevierViewall">extension from a myocardial site&#59;</p></li><li class="elsevierStyleListItem" id="lsti0070"><span class="elsevierStyleLabel">4&#46;</span><p id="par0155" class="elsevierStylePara elsevierViewall">perforating injury or surgery&#59;</p></li><li class="elsevierStyleListItem" id="lsti0075"><span class="elsevierStyleLabel">5&#46;</span><p id="par0160" class="elsevierStylePara elsevierViewall">extension from a subdiaphragmatic site&#46;</p></li></ul></p><p id="par0165" class="elsevierStylePara elsevierViewall">Pneumococcus is more commonly associated with contiguous spread from an intrathoracic site&#44; while <span class="elsevierStyleItalic">Staphylococcus aureus</span> is more often involved in hematogenous spread&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Purulent pericarditis is nowadays very rare&#44; occurring most frequently in individuals with previous pericardial disease treated by chemotherapy&#44; and in those who have undergone cardiac surgery or are receiving dialysis&#59; immunosuppression&#44; alcoholism and chest trauma are predisposing factors&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Before the advent of antibiotic therapy&#44; it was a common complication of pneumonia&#44; endocarditis&#44; meningitis and other infections of varying severity&#44; including of bone&#44; skin and the ear&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">A retrospective analysis of a Spanish hospital population of 593 601 patients between 1972 and 1991 found 33 cases of purulent pericarditis&#44; of which only 19 &#40;57&#37;&#41; were diagnosed in life&#44; basically because the diagnosis was not considered&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> presents a review of the literature&#44; covering etiology&#44; bacteriology&#44; associated comorbidities&#44; treatment and outcome&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0180" class="elsevierStylePara elsevierViewall">A patient with sepsis and a known underlying disease that explains the presence of PE makes prompt diagnosis of purulent pericarditis more difficult&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The diagnosis can only be confirmed by pericardiocentesis &#40;which in such cases in therapeutic&#41; by means of macroscopic examination of the fluid&#44; which has the biochemical characteristics of an exudate and should be subjected to microscopic study&#44; direct and in culture&#44; to screen for bacteria&#44; fungi and AARB&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Treatment must include drainage of the pericardial space&#44; combined with systemic antibiotic therapy&#44; initially empirical &#40;vancomycin and ceftriaxone or imipenem&#44; meropenem or piperacillin-tazobactam&#44; together with fluconazole in immunocompromised patients&#41;&#44; and then adjusted according to the results of microbiological study&#59; local antibiotic therapy confers no benefit&#46; Antibiotic therapy should be continued for at least 28 days&#44; or until fever has subsided and there are no laboratory signs of infection&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">The strategy adopted to achieve complete drainage of the pericardial space will depend on the human and technical resources of the institution treating the patient<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;11</span></a>&#58;<ul class="elsevierStyleList" id="lis0025"><li class="elsevierStyleListItem" id="lsti0080"><span class="elsevierStyleLabel">1&#46;</span><p id="par0195" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Pericardiocentesis&#46;</span> This is the simplest and fastest method&#44; but is often ineffective in draining thick&#44; loculated fibrinous fluid&#46; It also the technique that most frequently leads to development of constrictive pericarditis&#46; Intrapericardial infusion of fibrinolytics can increase its therapeutic efficacy but is associated with complications&#44; and is thus not generally recommended&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p></li><li class="elsevierStyleListItem" id="lsti0085"><span class="elsevierStyleLabel">2&#46;</span><p id="par0200" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Pericardiotomy</span> &#40;creating a pericardial window&#44; subxiphoid if an isolated procedure&#41;&#46; This is the method recommended in the European Society of Cardiology guidelines&#44; since it is associated with a higher success rate and a lower incidence of constrictive pericarditis&#46;</p></li><li class="elsevierStyleListItem" id="lsti0090"><span class="elsevierStyleLabel">3&#46;</span><p id="par0205" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Pericardiectomy&#46;</span> This is associated with mortality of 8&#37; but it is the approach than resolves all situations&#44; even the most complicated &#40;adhesions&#44; loculated effusions or persistent infection&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p></li></ul></p><p id="par0210" class="elsevierStylePara elsevierViewall">Without drainage of the pericardial space&#44; purulent pericarditis leads inexorably to death&#46; Mortality in patients who are promptly diagnosed and appropriately treated is 40&#37;&#44; generally due to cardiac tamponade&#44; septic shock or constriction&#46; Mortality increases the longer diagnosis and treatment are delayed&#44; and is higher in those with <span class="elsevierStyleItalic">S&#46; aureus</span> infection and in malnourished patients&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusions</span><p id="par0215" class="elsevierStylePara elsevierViewall">The interest of these two cases resides mainly in the question of the approach to adopt in a septic patient with PE&#46; Effusions with persistent fever&#44; of known or unknown origin&#44; should always raise the possibility of purulent pericarditis&#46; This is true for both immunocompromised patients and previously healthy individuals who&#44; even if they have no predisposing condition&#44; have the same risk if they develop pneumonia &#8211; the main cause of purulent pericarditis identified in various series&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;7&#8211;10</span></a> In addition&#44; although a diagnosis of purulent pericarditis is more likely the closer the primary infection site is to the pericardium&#44; septic emboli from a suppurative site can lead to pericardial&#44; myocardial or mediastinal spread through bronchial arteries without involving the rest of the systemic circulation&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> which was the most likely mechanism in the first case presented&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Prompt diagnosis of purulent pericarditis and initiation of appropriate treatment are the mainstays of successful management of this rare but potentially lethal entity&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflicts of interest</span><p id="par0225" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The authors present two cases of purulent pericarditis secondary to pneumococcus pneumonia&#44; a rare entity in the antibiotic era&#44; one of them in an apparently healthy person&#46; A systematized diagnostic approach to moderate pericardial effusion is presented&#44; together with a review of purulent pericarditis&#46; The presence of pericardial effusion with persistent fever with or without known etiology&#44; particularly in the immunocompromised but also in the apparently healthy patient&#44; should always raise the possibility of purulent pericarditis&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Os autores apresentam dois casos de pericardite purulenta secund&#225;ria a pneumonia por <span class="elsevierStyleItalic">pneumococos</span>&#44; um deles num doente sem antecedentes patol&#243;gicos conhecidos&#46; &#201; feita uma sistematiza&#231;&#227;o da abordagem diagn&#243;stica ao derrame peric&#225;rdico de moderadas dimens&#245;es e uma revis&#227;o da pericardite purulenta&#44; uma entidade muito rara na era da antibioterapia&#46; A constata&#231;&#227;o de derrame peric&#225;rdico com quadro de febre persistente&#44; com ou sem origem conhecida&#44; fundamentalmente no doente com compromisso imune&#44; mas tamb&#233;m no aparentemente saud&#225;vel&#44; deve levantar-se sempre a possibilidade de pericardite purulenta&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Ferreira dos Santos L&#44; Moreira D&#44; Ribeiro P&#44; et al&#46; Pericardite purulenta&#58; um diagn&#243;stico raro&#46; Rev Port Cardiol&#46; 2013&#59;32&#58;721&#8211;727&#46;</p>"
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        "etiqueta" => "Figure 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr5.jpeg"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Chest X-ray &#40;A&#41; and transthoracic echocardiography &#40;B&#41; at admission&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "fig0030"
        "etiqueta" => "Figure 6"
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        "mostrarFloat" => true
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        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr6.jpeg"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Pericardial fluid of purulent appearance&#46;</p>"
        ]
      ]
      6 => array:7 [
        "identificador" => "fig0035"
        "etiqueta" => "Figure 7"
        "tipo" => "MULTIMEDIAFIGURA"
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        "figura" => array:1 [
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            "imagen" => "gr7.jpeg"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Chest X-ray at discharge&#46;</p>"
        ]
      ]
      7 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
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        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Number of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Comorbidities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Origin of infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Bacteriology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Outcome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sagrista-Sauleda et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alcoholism&#44; rheumatoid arthritis&#44; ulcerous colitis &#40;n&#61;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pneumonia &#40;n&#61;10&#41;Peritonsilar abscess&#44; cervical abscess&#44; mediastinitis &#40;n&#61;5&#41;Sepsis &#40;skin&#44; oral cavity&#44; parenteral nutrition&#44; colon cancer&#41; &#40;n&#61;4&#41;Periodontal infection&#44; oral abscess&#44; mediastinitis &#40;n&#61;3&#41;Biliary tract infection &#40;n&#61;3&#41;Urinary tract infection &#40;n&#61;2&#41;Catheter-related sepsis&#44; including temporary pacemaker &#40;n&#61;2&#41;Post-traumatic subphrenic abscess &#40;n&#61;1&#41;Meningitis &#40;n&#61;1&#41;Mastoiditis &#40;n&#61;1&#41;Liver transplant &#40;n&#61;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Peptococcus</span> sp&#46;&#44; Gram-negative&#44; anaerobic &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Streptococcus milleri</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Streptococcus pneumoniae</span> &#40;n&#61;2&#41;<span class="elsevierStyleItalic">Streptococcus mitis</span>&#44; <span class="elsevierStyleItalic">Bacteroides</span> sp&#46;&#44; Gram-negative&#44; anaerobic &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Staphylococcus aureus</span> &#40;n&#61;2&#41;<span class="elsevierStyleItalic">Clostridium septicum</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> &#40;n&#61;2&#41;<span class="elsevierStyleItalic">Escherichia coli</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Staphylococcus aureus&#44; S&#46; mitis</span>&#44; <span class="elsevierStyleItalic">P&#46; aeruginosa</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Klebsiella</span> sp&#46;&#44; <span class="elsevierStyleItalic">E&#46; faecalis&#44; Proteus</span> sp&#46; &#40;n&#61;1&#41;<span class="elsevierStyleItalic">E&#46; coli</span>&#44; <span class="elsevierStyleItalic">Klebsiella</span> sp&#46; &#40;n&#61;1&#41;<span class="elsevierStyleItalic">E&#46; coli</span>&#44; anaerobic &#40;n&#61;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pericardiocentesis followed by pericardiectomy &#40;n&#61;12&#41;Pericardiectomy as initial approach &#40;n&#61;4&#41;Pericardiocentesis &#40;n&#61;2&#41;Post-mortem diagnosis &#40;n&#61;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Death &#40;n&#61;3&#44; due to renal failure n&#61;1&#44; complications due to pericardial disease n&#61;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Kauffman et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chronic alcoholism &#40;n&#61;2&#41;&#44; hypogammaglobulinemia &#40;n&#61;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pneumonia &#40;n&#61;81&#41;Pneumonia and empyema &#40;n&#61;58&#41;Otitis media &#40;n&#61;6&#41;Arthritis &#40;n&#61;2&#41;Subcutaneous abscess &#40;n&#61;2&#41;Meningitis &#40;n&#61;1&#41;Endocarditis &#40;n&#61;1&#41;None identified &#40;n&#61;2&#41;NB Some patients had more than one site of infection&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">S&#46; pneumoniae</span> &#40;all patients&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None &#40;n&#61;52&#41;Pericardiectomy &#40;n&#61;49&#41;Pericardiectomy &#43; antibiotic therapy &#40;n&#61;10&#41;Pericardiocentesis &#40;n&#61;1&#41;Pericardiocentesis &#43; antibiotic therapy &#40;n&#61;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Death &#40;n&#61;64&#44; including all who received no treatment&#44; 19 who underwent pericardiectomy only&#44; and one who underwent pericardiocentesis only&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rubin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Liver failure &#40;n&#61;2&#41;Uremia &#40;n&#61;1&#41;Diabetes &#40;n&#61;3&#41;Leukopenia &#40;n&#61;1&#41;Third degree burns &#40;n&#61;2&#41;Acute lymphoblastic leukemia &#40;n&#61;1&#41;Iatrogenic immunosuppression &#40;n&#61;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Esophageal perforation following thoracic surgery &#40;n&#61;2&#41;Wound infection following thoracic surgery &#40;n&#61;6&#41;Pneumonia &#40;n&#61;6&#41;Mediastinal abscess &#40;n&#61;1&#41;Infective endocarditis &#40;n&#61;3&#41;Intramyocardial abscess &#40;n&#61;2&#41;Bacteremia &#40;n&#61;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">S&#46; aureus</span> &#40;n&#61;8&#41;<span class="elsevierStyleItalic">S&#46; pneumoniae</span> &#40;n&#61;2&#41;<span class="elsevierStyleItalic">Haemophilus influenzae</span> &#40;n&#61;2&#41;<span class="elsevierStyleItalic">Neisseria meningitidis</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">P&#46; aeruginosa</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Bacteroides</span> spp&#46; &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Salmonella typhimurium</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Nocardia asteroides</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">S&#46; mitis</span> &#40;n&#61;1&#41;Mixed bacterial infections &#40;n&#61;2&#41;<span class="elsevierStyleItalic">Candida</span> spp&#46; &#40;n&#61;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antibiotic therapy &#43; pericardiocentesis &#40;n&#61;11&#41;Antibiotic therapy without pericardiocentesis &#40;n&#61;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Death &#40;n&#61;15&#44; patients who received antibiotic therapy only&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Klacsmann et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">200&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chronic renal disease &#40;n&#61;16&#41;Cancer &#40;13&#41;Acute myocardial infarction &#40;n&#61;2&#41;Diabetes&#44; myeloproliferative disease &#40;n&#61;10&#41;Sickle-cell anemia &#40;n&#61;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pneumonia &#40;n&#61;104&#41;Bacteremia &#40;n&#61;44&#41;Endocarditis&#47;myocardial abscess &#40;n&#61;30&#41;Perforating chest injury &#40;n&#61;18&#41;Suppurative subdiaphragmatic lesion &#40;n&#61;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Pneumococcus</span> sp&#46; &#40;n&#61;69&#41;<span class="elsevierStyleItalic">Staphylococcus</span> sp&#46; &#40;n&#61;38&#41;<span class="elsevierStyleItalic">Streptococcus</span> sp&#46; &#40;n&#61;21&#41;<span class="elsevierStyleItalic">Proteus</span> sp&#46;&#44; <span class="elsevierStyleItalic">E&#46; coli</span>&#44; <span class="elsevierStyleItalic">Pseudomonas</span> sp&#46;&#44; <span class="elsevierStyleItalic">Klebsiella</span> sp&#46; &#40;n&#61;25&#41;<span class="elsevierStyleItalic">Salmonella</span>&#47;<span class="elsevierStyleItalic">Shigella</span> &#40;n&#61;4&#41;<span class="elsevierStyleItalic">N&#46; meningitidis</span> &#40;n&#61;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-mortem diagnosis &#40;n&#61;200&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Death &#40;all patients&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Purulent pericarditis&#58; brief review of the literature&#46;</p>"
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    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:12 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pericardial diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;M&#46; LeWinter"
                            1 => "S&#46; Kabbani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "titulo" => "Heart disease&#58; a textbook of cardiovascular medicine"
                        "paginaInicial" => "1757"
                        "serieFecha" => "2005"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical clues to the causes of large pericardial effusions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Sagrista-Sauleda"
                            1 => "J&#46; Merce"
                            2 => "G&#46; Permanyer-Miralda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "2000"
                        "volumen" => "109"
                        "paginaInicial" => "95"
                        "paginaFinal" => "101"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10967149"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Large symptomatic pericardial effusion as the presentation of unrecognized cancer&#58; a study in 173 consecutive patients undergoing pericardiocentesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Ben-Horin"
                            1 => "A&#46; Bank"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Medicine &#40;Baltimore&#41;"
                        "fecha" => "2006"
                        "volumen" => "85"
                        "paginaInicial" => "49"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
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Case report
Purulent pericarditis: A rare diagnosis
Pericardite purulenta: um diagnóstico raro
Luís Ferreira dos Santosa,
Corresponding author
luisferreirasantos@gmail.com

Corresponding author.
, Davide Moreiraa, Pedro Ribeirob, Bruno Rodriguesa, Emanuel Correiaa, Luís Nunesa, Miguel Sequeirab, Ana Albuquerqueb, Inês Barrosb, José Pedro Saraivab, Oliveira Santosa
a Serviço de Cardiologia, Centro Hospital Tondela-Viseu, Viseu, Portugal
b Unidade de Cuidados Intensivos Polivalente, Centro Hospital-Tondela, Viseu, Portugal
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Pericardial disease mainly manifests as pericarditis and&#47;or pericardial effusion &#40;PE&#41; and is caused by a variety of etiologies&#44; including infection&#44; inflammation and neoplasms&#44; or iatrogenic&#44; traumatic or metabolic origin&#44; or unknown &#40;idiopathic&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">It may occur in isolation&#44; or be one component&#44; of lesser or greater clinical importance&#44; in the presentation of entities with systemic involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case reports</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Case 1</span><p id="par0015" class="elsevierStylePara elsevierViewall">A 39-year-old woman&#44; with no history of disease and not taking regular medication&#44; came to the emergency department for right lower back pain and worsening dyspnea on moderate exertion of one week&#39;s duration&#46; She reported no fever&#44; cough or expectoration&#44; and was normotensive&#44; with tachyarrhythmia and mild hypoxemic respiratory failure&#46; Laboratory tests showed signs of inflammation and infection&#44; the ECG revealed atrial fibrillation with rapid ventricular rate &#40;&#8776;115 bpm&#41;&#44; and the chest X-ray showed increased cardiothoracic index and segmental infiltrate in the mid third of the right hemithorax &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was admitted with a diagnosis of community-acquired pneumonia&#44; and empirical antibiotic therapy was begun with ceftriaxone and azithromycin&#46; Thoracic computed tomography &#40;CT&#41; on the second day of hospitalization showed bilateral lung condensations&#44; bilateral pleural effusion and PE&#44; which on transthoracic echocardiography &#40;TTE&#41; measured 10 mm at the posterior wall in diastole&#44; with no signs of cardiac tamponade&#46; On the same day&#44; there was a sudden deterioration of the clinical setting&#44; evolving to septic shock&#44; and the patient was transferred to the intensive care unit&#46; Inotropic support was required for three days&#44; but chemical cardioversion to sinus rhythm was achieved on the second day&#46; On the third day&#44; multisusceptible <span class="elsevierStyleItalic">Streptococcus pneumoniae</span> was identified in blood samples collected at admission and therapy was begun with penicillin G&#46; Respiratory and hemodynamic stabilization was achieved from the fourth day&#44; although the patient still required mechanical ventilation and remained febrile&#44; with no resolution of the infection on laboratory tests&#46; The cardiac silhouette was still enlarged and serial TTE showed progressive worsening of the PE&#44; which measured 20 mm at the posterior wall in diastole on the 10th day&#44; with signs of cardiac tamponade &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">Figures 2 and 3</a>A&#41;&#46; Pericardiocentesis was therefore performed for diagnostic purposes and drainage&#44; 800 cc of fibrinous purulent fluid being drained &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>B&#41;&#44; which was negative on bacteriological study&#44; both direct and in culture&#46; Screening for acid-alcohol resistant bacilli &#40;AARB&#41; was also negative&#46; Subsequent TTE revealed resolution of the effusion&#44; accompanied by clinical&#44; radiological and laboratory improvement &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Figure 4</a>&#41;&#46; Screening for immune deficiency diseases was negative&#46; The patient presented no constrictive pattern on TTE at 12-month follow-up&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Case 2</span><p id="par0025" class="elsevierStylePara elsevierViewall">A 33-year-old man had a history of congenital hypogammaglobulinemia &#40;diagnosed in 2001&#41;&#44; chronic alcoholism and recurrent pneumonia&#44; the last episode &#40;in 2005&#41; having been complicated by pleural effusion requiring decortication&#46; He had taken no medication since 2005&#46; He came to the emergency department for fever and worsening dyspnea over the previous five days&#46; At admission&#44; he was febrile&#44; prostrate&#44; tachycardic and hypotensive&#46; Laboratory tests showed marked elevation of inflammatory and infectious parameters and arterial blood gas analysis revealed hypoxemic respiratory failure&#46; A chest X-ray showed a markedly enlarged cardiac silhouette&#44; with no parenchymal lung lesions&#59; TTE was therefore performed&#44; which confirmed the presence of a PE&#44; measuring 23 mm at the posterior wall in diastole&#44; with abnormal motion and diastolic collapse of the right atrial free wall &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Figure 5</a>A and B&#41;&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">In view of the setting of septic&#47;obstructive shock&#44; the patient was transferred to the intensive care unit&#44; and diagnostic and therapeutic pericardiocentesis was performed&#44; 700 cc of purulent fluid being drained &#40;<a class="elsevierStyleCrossRef" href="#fig0030">Figure 6</a>&#41;&#46;</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Thoracic CT following pericardiocentesis showed a moderate PE&#44; a small right pleural effusion and an area of parenchymal condensation in the superior and posterior segments of the left lower lobe&#44; with air bronchograms&#44; highly suggestive of inflammation&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The patient remained in cardiocirculatory shock and required inotropic support until the seventh day of hospitalization&#46; Initially&#44; the fluid drained was purulent&#44; and then became serofibrinous&#46; On the ninth day&#44; the absence of pericardial fluid and evidence of a considerable reduction in the effusion &#40;to 3 mm&#41; at the posterior wall in diastole led to removal of the drain&#46; Empirical antibiotic therapy with ceftriaxone and vancomycin had been begun at admission&#44; which was changed to penicillin G on the third day following confirmation of multisusceptible <span class="elsevierStyleItalic">Streptococcus pneumoniae</span> bacteremia&#46; The presence of pneumococcus with the same susceptibility was confirmed in pericardial fluid&#44; and screening for AARB was negative&#46; Immunoglobulin was administered for four days&#44; which was well tolerated and without complications&#46; Fever returned on the 14th day&#44; and TTE revealed a 15-mm PE at the posterior wall in diastole&#59; repeat thoracic CT showed loci of pleural empyema&#46; The patient was transferred to the thoracic surgery department of Coimbra University Hospitals&#44; where he underwent surgical drainage and decortication of both pleurae&#44; pericardiotomy and creation of a pleuropericardial window&#44; resulting in considerable improvement in clinical and laboratory parameters &#40;<a class="elsevierStyleCrossRef" href="#fig0035">Figure 7</a>&#41;&#46;</p><elsevierMultimedia ident="fig0035"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">The patient presented no constrictive pattern on TTE at 12-month follow-up&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Discussion</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Pericardial effusion</span><p id="par0050" class="elsevierStylePara elsevierViewall">PE may develop as a result of pericarditis or arise as an epiphenomenon of greater or less clinical significance in a range of systemic disorders&#46; The etiology of moderate PE is idiopathic in 29&#37; of cases&#44; but can be iatrogenic &#40;16&#37;&#41;&#44; or due to neoplasms &#40;13&#37;&#41;&#44; myocardial infarction &#40;8&#37;&#41;&#44; uremia &#40;6&#37;&#41;&#44; connective tissue or thyroid disease &#40;5&#37;&#41; or infection &#40;2&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The etiological distribution of PE of acute presentation with cardiorespiratory symptoms is different&#58; neoplasm &#40;33&#37;&#41;&#44; idiopathic &#40;14&#37;&#41;&#44; acute pericarditis &#40;12&#37;&#41;&#44; trauma &#40;12&#37;&#41;&#44; uremia &#40;6&#37;&#41;&#44; post-pericardiotomy &#40;5&#37;&#41; and infection &#40;5&#37;&#44; 4&#37; bacterial&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">It is essential to exclude PE in the following clinical contexts&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0065" class="elsevierStylePara elsevierViewall">acute pericarditis&#59;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0070" class="elsevierStylePara elsevierViewall">enlarged cardiac silhouette without pulmonary congestion&#59;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#46;</span><p id="par0075" class="elsevierStylePara elsevierViewall">severe hemodynamic deterioration following an acute coronary event&#44; heart surgery or invasive cardiac procedure&#59; and</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#46;</span><p id="par0080" class="elsevierStylePara elsevierViewall">persistent unexplained fever&#44; whether or not the cause is determined&#46;</p></li></ul></p><p id="par0085" class="elsevierStylePara elsevierViewall">A systematic approach to PE involves three stages<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">1&#46;</span><p id="par0090" class="elsevierStylePara elsevierViewall">confirmation by TTE&#59;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">2&#46;</span><p id="par0095" class="elsevierStylePara elsevierViewall">assessment of hemodynamic repercussions &#40;covering a wide spectrum of severity from benign to life-threatening&#44; depending on its volume&#44; the rate at which the effusion accumulates and pericardial elasticity&#41;&#59; and</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">3&#46;</span><p id="par0100" class="elsevierStylePara elsevierViewall">determination of etiology&#46;</p></li></ul></p><p id="par0105" class="elsevierStylePara elsevierViewall">With regard to etiological determination&#44; certain clinical contexts justify a non-invasive approach&#44; including recent myocardial infarction&#44; hypothyroidism and renal failure&#46; In other cases&#44; diagnosis is based on clinical evaluation as well as biochemical and bacteriological study of pericardial fluid or of the pericardium itself&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Pericardiocentesis has limited diagnostic value &#40;6&#37; of cases&#41; in acute pericarditis&#46; In patients with large chronic effusions&#44; analysis of pericardial fluid leads to a definitive diagnosis in 36&#37; and a probable diagnosis in 40&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Pericardiocentesis guided by echography or fluoroscopy is formally indicated<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> in cases of&#58;<ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">1&#46;</span><p id="par0120" class="elsevierStylePara elsevierViewall">cardiac tamponade&#59;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">2&#46;</span><p id="par0125" class="elsevierStylePara elsevierViewall">effusion of &#62;20 mm that does not respond after a week of conservative treatment with non-steroidal anti-inflammatory drugs&#59; and</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">3&#46;</span><p id="par0130" class="elsevierStylePara elsevierViewall">clinical suspicion of purulent&#44; tuberculous or neoplastic pericarditis&#46;</p></li></ul></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Purulent pericarditis</span><p id="par0135" class="elsevierStylePara elsevierViewall">Purulent pericarditis is defined as an infection in the pericardial space that produces macroscopically or microscopically purulent fluid&#46; It may be primary &#40;extremely rare&#41; or secondary to another infectious process&#46; There are five pathogenic mechanisms that can lead to invasion of the pericardial space in secondary purulent pericarditis<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#58;<ul class="elsevierStyleList" id="lis0030"><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">1&#46;</span><p id="par0140" class="elsevierStylePara elsevierViewall">contiguous spread from an intrathoracic site&#59;</p></li><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">2&#46;</span><p id="par0145" class="elsevierStylePara elsevierViewall">hematogenous spread&#59;</p></li><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">3&#46;</span><p id="par0150" class="elsevierStylePara elsevierViewall">extension from a myocardial site&#59;</p></li><li class="elsevierStyleListItem" id="lsti0070"><span class="elsevierStyleLabel">4&#46;</span><p id="par0155" class="elsevierStylePara elsevierViewall">perforating injury or surgery&#59;</p></li><li class="elsevierStyleListItem" id="lsti0075"><span class="elsevierStyleLabel">5&#46;</span><p id="par0160" class="elsevierStylePara elsevierViewall">extension from a subdiaphragmatic site&#46;</p></li></ul></p><p id="par0165" class="elsevierStylePara elsevierViewall">Pneumococcus is more commonly associated with contiguous spread from an intrathoracic site&#44; while <span class="elsevierStyleItalic">Staphylococcus aureus</span> is more often involved in hematogenous spread&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Purulent pericarditis is nowadays very rare&#44; occurring most frequently in individuals with previous pericardial disease treated by chemotherapy&#44; and in those who have undergone cardiac surgery or are receiving dialysis&#59; immunosuppression&#44; alcoholism and chest trauma are predisposing factors&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Before the advent of antibiotic therapy&#44; it was a common complication of pneumonia&#44; endocarditis&#44; meningitis and other infections of varying severity&#44; including of bone&#44; skin and the ear&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">A retrospective analysis of a Spanish hospital population of 593 601 patients between 1972 and 1991 found 33 cases of purulent pericarditis&#44; of which only 19 &#40;57&#37;&#41; were diagnosed in life&#44; basically because the diagnosis was not considered&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> presents a review of the literature&#44; covering etiology&#44; bacteriology&#44; associated comorbidities&#44; treatment and outcome&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0180" class="elsevierStylePara elsevierViewall">A patient with sepsis and a known underlying disease that explains the presence of PE makes prompt diagnosis of purulent pericarditis more difficult&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The diagnosis can only be confirmed by pericardiocentesis &#40;which in such cases in therapeutic&#41; by means of macroscopic examination of the fluid&#44; which has the biochemical characteristics of an exudate and should be subjected to microscopic study&#44; direct and in culture&#44; to screen for bacteria&#44; fungi and AARB&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Treatment must include drainage of the pericardial space&#44; combined with systemic antibiotic therapy&#44; initially empirical &#40;vancomycin and ceftriaxone or imipenem&#44; meropenem or piperacillin-tazobactam&#44; together with fluconazole in immunocompromised patients&#41;&#44; and then adjusted according to the results of microbiological study&#59; local antibiotic therapy confers no benefit&#46; Antibiotic therapy should be continued for at least 28 days&#44; or until fever has subsided and there are no laboratory signs of infection&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">The strategy adopted to achieve complete drainage of the pericardial space will depend on the human and technical resources of the institution treating the patient<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;11</span></a>&#58;<ul class="elsevierStyleList" id="lis0025"><li class="elsevierStyleListItem" id="lsti0080"><span class="elsevierStyleLabel">1&#46;</span><p id="par0195" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Pericardiocentesis&#46;</span> This is the simplest and fastest method&#44; but is often ineffective in draining thick&#44; loculated fibrinous fluid&#46; It also the technique that most frequently leads to development of constrictive pericarditis&#46; Intrapericardial infusion of fibrinolytics can increase its therapeutic efficacy but is associated with complications&#44; and is thus not generally recommended&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p></li><li class="elsevierStyleListItem" id="lsti0085"><span class="elsevierStyleLabel">2&#46;</span><p id="par0200" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Pericardiotomy</span> &#40;creating a pericardial window&#44; subxiphoid if an isolated procedure&#41;&#46; This is the method recommended in the European Society of Cardiology guidelines&#44; since it is associated with a higher success rate and a lower incidence of constrictive pericarditis&#46;</p></li><li class="elsevierStyleListItem" id="lsti0090"><span class="elsevierStyleLabel">3&#46;</span><p id="par0205" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Pericardiectomy&#46;</span> This is associated with mortality of 8&#37; but it is the approach than resolves all situations&#44; even the most complicated &#40;adhesions&#44; loculated effusions or persistent infection&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p></li></ul></p><p id="par0210" class="elsevierStylePara elsevierViewall">Without drainage of the pericardial space&#44; purulent pericarditis leads inexorably to death&#46; Mortality in patients who are promptly diagnosed and appropriately treated is 40&#37;&#44; generally due to cardiac tamponade&#44; septic shock or constriction&#46; Mortality increases the longer diagnosis and treatment are delayed&#44; and is higher in those with <span class="elsevierStyleItalic">S&#46; aureus</span> infection and in malnourished patients&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusions</span><p id="par0215" class="elsevierStylePara elsevierViewall">The interest of these two cases resides mainly in the question of the approach to adopt in a septic patient with PE&#46; Effusions with persistent fever&#44; of known or unknown origin&#44; should always raise the possibility of purulent pericarditis&#46; This is true for both immunocompromised patients and previously healthy individuals who&#44; even if they have no predisposing condition&#44; have the same risk if they develop pneumonia &#8211; the main cause of purulent pericarditis identified in various series&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;7&#8211;10</span></a> In addition&#44; although a diagnosis of purulent pericarditis is more likely the closer the primary infection site is to the pericardium&#44; septic emboli from a suppurative site can lead to pericardial&#44; myocardial or mediastinal spread through bronchial arteries without involving the rest of the systemic circulation&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> which was the most likely mechanism in the first case presented&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Prompt diagnosis of purulent pericarditis and initiation of appropriate treatment are the mainstays of successful management of this rare but potentially lethal entity&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflicts of interest</span><p id="par0225" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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          "titulo" => "Keywords"
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          "titulo" => "Introduction"
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          "titulo" => "Discussion"
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              "identificador" => "sec0030"
              "titulo" => "Pericardial effusion"
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            1 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Purulent pericarditis"
            ]
          ]
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        7 => array:2 [
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          "titulo" => "Conclusions"
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        8 => array:2 [
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          "titulo" => "Conflicts of interest"
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        9 => array:1 [
          "titulo" => "References"
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    "pdfFichero" => "main.pdf"
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    "fechaRecibido" => "2011-07-25"
    "fechaAceptado" => "2013-04-11"
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        0 => array:4 [
          "clase" => "keyword"
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            0 => "Bacterial pericarditis"
            1 => "Purulent pericarditis"
            2 => "Pericardial effusion"
            3 => "Tamponade"
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            0 => "Pericardite bacteriana"
            1 => "Pericardite purulenta"
            2 => "Derrame peric&#225;rdico"
            3 => "Tamponamento"
            4 => "Pneumonia"
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The authors present two cases of purulent pericarditis secondary to pneumococcus pneumonia&#44; a rare entity in the antibiotic era&#44; one of them in an apparently healthy person&#46; A systematized diagnostic approach to moderate pericardial effusion is presented&#44; together with a review of purulent pericarditis&#46; The presence of pericardial effusion with persistent fever with or without known etiology&#44; particularly in the immunocompromised but also in the apparently healthy patient&#44; should always raise the possibility of purulent pericarditis&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Os autores apresentam dois casos de pericardite purulenta secund&#225;ria a pneumonia por <span class="elsevierStyleItalic">pneumococos</span>&#44; um deles num doente sem antecedentes patol&#243;gicos conhecidos&#46; &#201; feita uma sistematiza&#231;&#227;o da abordagem diagn&#243;stica ao derrame peric&#225;rdico de moderadas dimens&#245;es e uma revis&#227;o da pericardite purulenta&#44; uma entidade muito rara na era da antibioterapia&#46; A constata&#231;&#227;o de derrame peric&#225;rdico com quadro de febre persistente&#44; com ou sem origem conhecida&#44; fundamentalmente no doente com compromisso imune&#44; mas tamb&#233;m no aparentemente saud&#225;vel&#44; deve levantar-se sempre a possibilidade de pericardite purulenta&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Ferreira dos Santos L&#44; Moreira D&#44; Ribeiro P&#44; et al&#46; Pericardite purulenta&#58; um diagn&#243;stico raro&#46; Rev Port Cardiol&#46; 2013&#59;32&#58;721&#8211;727&#46;</p>"
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Chest X-ray &#40;A&#41; and transthoracic echocardiography &#40;B&#41; at admission&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Number of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Comorbidities&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Origin of infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Bacteriology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Outcome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sagrista-Sauleda et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alcoholism&#44; rheumatoid arthritis&#44; ulcerous colitis &#40;n&#61;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pneumonia &#40;n&#61;10&#41;Peritonsilar abscess&#44; cervical abscess&#44; mediastinitis &#40;n&#61;5&#41;Sepsis &#40;skin&#44; oral cavity&#44; parenteral nutrition&#44; colon cancer&#41; &#40;n&#61;4&#41;Periodontal infection&#44; oral abscess&#44; mediastinitis &#40;n&#61;3&#41;Biliary tract infection &#40;n&#61;3&#41;Urinary tract infection &#40;n&#61;2&#41;Catheter-related sepsis&#44; including temporary pacemaker &#40;n&#61;2&#41;Post-traumatic subphrenic abscess &#40;n&#61;1&#41;Meningitis &#40;n&#61;1&#41;Mastoiditis &#40;n&#61;1&#41;Liver transplant &#40;n&#61;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Peptococcus</span> sp&#46;&#44; Gram-negative&#44; anaerobic &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Streptococcus milleri</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Streptococcus pneumoniae</span> &#40;n&#61;2&#41;<span class="elsevierStyleItalic">Streptococcus mitis</span>&#44; <span class="elsevierStyleItalic">Bacteroides</span> sp&#46;&#44; Gram-negative&#44; anaerobic &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Staphylococcus aureus</span> &#40;n&#61;2&#41;<span class="elsevierStyleItalic">Clostridium septicum</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> &#40;n&#61;2&#41;<span class="elsevierStyleItalic">Escherichia coli</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Staphylococcus aureus&#44; S&#46; mitis</span>&#44; <span class="elsevierStyleItalic">P&#46; aeruginosa</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Klebsiella</span> sp&#46;&#44; <span class="elsevierStyleItalic">E&#46; faecalis&#44; Proteus</span> sp&#46; &#40;n&#61;1&#41;<span class="elsevierStyleItalic">E&#46; coli</span>&#44; <span class="elsevierStyleItalic">Klebsiella</span> sp&#46; &#40;n&#61;1&#41;<span class="elsevierStyleItalic">E&#46; coli</span>&#44; anaerobic &#40;n&#61;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pericardiocentesis followed by pericardiectomy &#40;n&#61;12&#41;Pericardiectomy as initial approach &#40;n&#61;4&#41;Pericardiocentesis &#40;n&#61;2&#41;Post-mortem diagnosis &#40;n&#61;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Death &#40;n&#61;3&#44; due to renal failure n&#61;1&#44; complications due to pericardial disease n&#61;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Kauffman et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chronic alcoholism &#40;n&#61;2&#41;&#44; hypogammaglobulinemia &#40;n&#61;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pneumonia &#40;n&#61;81&#41;Pneumonia and empyema &#40;n&#61;58&#41;Otitis media &#40;n&#61;6&#41;Arthritis &#40;n&#61;2&#41;Subcutaneous abscess &#40;n&#61;2&#41;Meningitis &#40;n&#61;1&#41;Endocarditis &#40;n&#61;1&#41;None identified &#40;n&#61;2&#41;NB Some patients had more than one site of infection&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">S&#46; pneumoniae</span> &#40;all patients&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None &#40;n&#61;52&#41;Pericardiectomy &#40;n&#61;49&#41;Pericardiectomy &#43; antibiotic therapy &#40;n&#61;10&#41;Pericardiocentesis &#40;n&#61;1&#41;Pericardiocentesis &#43; antibiotic therapy &#40;n&#61;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Death &#40;n&#61;64&#44; including all who received no treatment&#44; 19 who underwent pericardiectomy only&#44; and one who underwent pericardiocentesis only&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rubin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Liver failure &#40;n&#61;2&#41;Uremia &#40;n&#61;1&#41;Diabetes &#40;n&#61;3&#41;Leukopenia &#40;n&#61;1&#41;Third degree burns &#40;n&#61;2&#41;Acute lymphoblastic leukemia &#40;n&#61;1&#41;Iatrogenic immunosuppression &#40;n&#61;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Esophageal perforation following thoracic surgery &#40;n&#61;2&#41;Wound infection following thoracic surgery &#40;n&#61;6&#41;Pneumonia &#40;n&#61;6&#41;Mediastinal abscess &#40;n&#61;1&#41;Infective endocarditis &#40;n&#61;3&#41;Intramyocardial abscess &#40;n&#61;2&#41;Bacteremia &#40;n&#61;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">S&#46; aureus</span> &#40;n&#61;8&#41;<span class="elsevierStyleItalic">S&#46; pneumoniae</span> &#40;n&#61;2&#41;<span class="elsevierStyleItalic">Haemophilus influenzae</span> &#40;n&#61;2&#41;<span class="elsevierStyleItalic">Neisseria meningitidis</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">P&#46; aeruginosa</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Bacteroides</span> spp&#46; &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Salmonella typhimurium</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">Nocardia asteroides</span> &#40;n&#61;1&#41;<span class="elsevierStyleItalic">S&#46; mitis</span> &#40;n&#61;1&#41;Mixed bacterial infections &#40;n&#61;2&#41;<span class="elsevierStyleItalic">Candida</span> spp&#46; &#40;n&#61;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antibiotic therapy &#43; pericardiocentesis &#40;n&#61;11&#41;Antibiotic therapy without pericardiocentesis &#40;n&#61;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Death &#40;n&#61;15&#44; patients who received antibiotic therapy only&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Klacsmann et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">200&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chronic renal disease &#40;n&#61;16&#41;Cancer &#40;13&#41;Acute myocardial infarction &#40;n&#61;2&#41;Diabetes&#44; myeloproliferative disease &#40;n&#61;10&#41;Sickle-cell anemia &#40;n&#61;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pneumonia &#40;n&#61;104&#41;Bacteremia &#40;n&#61;44&#41;Endocarditis&#47;myocardial abscess &#40;n&#61;30&#41;Perforating chest injury &#40;n&#61;18&#41;Suppurative subdiaphragmatic lesion &#40;n&#61;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Pneumococcus</span> sp&#46; &#40;n&#61;69&#41;<span class="elsevierStyleItalic">Staphylococcus</span> sp&#46; &#40;n&#61;38&#41;<span class="elsevierStyleItalic">Streptococcus</span> sp&#46; &#40;n&#61;21&#41;<span class="elsevierStyleItalic">Proteus</span> sp&#46;&#44; <span class="elsevierStyleItalic">E&#46; coli</span>&#44; <span class="elsevierStyleItalic">Pseudomonas</span> sp&#46;&#44; <span class="elsevierStyleItalic">Klebsiella</span> sp&#46; &#40;n&#61;25&#41;<span class="elsevierStyleItalic">Salmonella</span>&#47;<span class="elsevierStyleItalic">Shigella</span> &#40;n&#61;4&#41;<span class="elsevierStyleItalic">N&#46; meningitidis</span> &#40;n&#61;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-mortem diagnosis &#40;n&#61;200&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Death &#40;all patients&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Purulent pericarditis&#58; brief review of the literature&#46;</p>"
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      ]
    ]
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Article information
ISSN: 21742049
Original language: English
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Idiomas
Revista Portuguesa de Cardiologia (English edition)
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